CN114869817A - Composition with whitening effect and preparation method thereof - Google Patents

Composition with whitening effect and preparation method thereof Download PDF

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CN114869817A
CN114869817A CN202210511175.3A CN202210511175A CN114869817A CN 114869817 A CN114869817 A CN 114869817A CN 202210511175 A CN202210511175 A CN 202210511175A CN 114869817 A CN114869817 A CN 114869817A
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extract
composition
preparation
whitening effect
mullein
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CN114869817B (en
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曹华
夏念民
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Hunan Yaoda Testing Technology Co ltd
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Miaofen Pharmaceutical Technology Guangzhou Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82Preparation or application process involves sonication or ultrasonication
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
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  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a composition with a whitening effect and a preparation method thereof, and belongs to the technical field of cosmetics. The composition with the whitening effect comprises the following components: glycerin, tea leaf extract, mullein extract, centella asiatica extract, bisabolol, and water. The composition has good whitening effect, simple formula composition and high safety, improves the inhibition effect on tyrosinase by compounding the verbascon extract and the tea extract, and is high in stability and convenient to store and transport; the raw materials have wide sources, the preparation method is simple, and the application prospect is good.

Description

Composition with whitening effect and preparation method thereof
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a composition with a whitening effect and a preparation method thereof.
Background
Melanin (Melanin) is mainly produced by melanocytes (melanocytes) in the basal layer of the epidermis of human skin, and it reduces the damage of ultraviolet rays to the skin. The content and distribution of melanin determine the color of the skin. However, abnormal accumulation of melanin in the basal layer causes hyperpigmentation to cause melasma, freckles, age spots, etc., affecting the quality of life of people. With the progress of the research on melanin biosynthesis, researchers found that tyrosinase plays an important role in melanin biosynthesis, which is a major rate-limiting enzyme in the conversion of tyrosine and dopa to melanin, and that its overexpression is a major cause of hyperpigmentation. Therefore, inhibiting the activity of tyrosinase can block the biosynthesis reaction chain of melanin, reduce the generation of melanin and realize the whitening effect. Therefore, with the attention of people to skin health and the pursuit of beauty at present, whitening products have great market demands and are an important cosmetic development direction. The skin whitening component mainly achieves the whitening effect by inhibiting the activity of tyrosinase or blocking the synthesis pathway of the tyrosinase for generating melanin, thereby reducing the generation of the melanin. Current skin lightening ingredients of this type include vitamin C ethyl ether and derivatives thereof, niacinamide, arbutin, hydroquinone and derivatives thereof, L-ascorbic acid and derivatives thereof, kojic acid and derivatives thereof, tranexamic acid, benzenediol and derivatives thereof, and the like. However, these ingredients also have some disadvantages, such as easy oxidative discoloration of the Vc product, general unsuitability for light environment, greater skin irritation due to niacinamide, intolerance to many people, single effect of arbutin and poor efficacy.
In the cosmetic market, the Chinese herbal medicine cosmetics account for about 30-40%, people have more comprehensive skin care requirements, and the cosmetics which are natural, safe and small in side effect are more favored by consumers. Because the traditional pure compound has high development difficulty, long period and high cost and is easy to generate larger irritation, the natural Chinese herbal medicine has the advantages of higher safety, easier preparation and the like. For example, chinese patent application CN202110851646.0 discloses a cosmetic raw material composition with skin whitening and anti-allergic effects, which is characterized in that: comprises collagen extract, yeast fermentation product filtrate, Glycyrrhiza glabra extract, rhodiola rosea extract, bletilla striata root extract, Ligusticum wallichii extract, centella asiatica extract and purslane extract; the raw materials are mixed according to the mass ratio: 80-85: 3-5: 2-2.5: 2-2.5: 2-3: 2-3: 2-3: 2-3, heating the raw material components to 40-50 ℃, stirring and dissolving, and compounding according to the proportion to obtain the cosmetic raw material composition product. The invention adopts various natural cosmetic raw material compositions, has comprehensive effect and good effect on whitening skin and resisting allergy, and has almost no side effect on skin because the cosmetic raw material compositions are all derived from natural substances.
With the increase of attention of people to skin health, it is very important to develop a natural ingredient whitening product which is safe and stable, has obvious effect and high cost performance. In view of the above, the invention provides a composition with good whitening effect, and better whitening effect and product characteristics are obtained by compounding traditional Chinese medicine extracts.
Disclosure of Invention
The invention aims to provide a novel composition with whitening effect and a preparation method thereof.
In order to achieve the purpose, the technical scheme of the invention is as follows:
firstly, the invention provides a composition with whitening effect, which comprises the following components: glycerin, tea leaf extract, mullein extract, centella asiatica extract, bisabolol, and water.
Preferably, the composition with whitening effect comprises the following components in percentage by weight:
10-25% of glycerin, 5-15% of tea extract, 0.3-2% of mullein extract, 2-10% of centella extract, 0.5-2% of bisabolol and water.
More preferably, the weight amount of the tea extract is more than five times of that of the mullein extract.
Further preferably, the composition with whitening effect comprises the following components in percentage by weight:
20% of glycerin, 5% of tea leaf extract, 1% of mullein extract, 4% of centella asiatica extract, 1% of bisabolol and water.
Preferably, the preparation method of the tea extract comprises the following steps: extracting folium Camelliae sinensis with ethanol for 1-3 times, centrifuging, collecting supernatant, and removing solvent to obtain folium Camelliae sinensis extract.
Further preferably, the volume fraction of the ethanol is 70%, the extraction temperature is 60-80 ℃, and the centrifugation time is 10-20 min.
Preferably, the preparation method of the centella asiatica extract comprises the following steps: extracting herba Centellae leaves with ethanol for 1-3 times, centrifuging, collecting supernatant, and removing solvent to obtain herba Centellae extract.
Further preferably, the volume fraction of the ethanol is 70%, the extraction temperature is 25-40 ℃, and the centrifugation time is 10-20 min.
Preferably, the preparation method of the mullein extract comprises the following steps: extracting herba Verbasci Thapsi with methanol, and heating and concentrating the extractive solution to 1/5 to obtain herba Verbasci Thapsi extract.
Further preferably, the volume fraction of the methanol is 50%, and the ratio of the extracted feed to the extracted liquid is 1: 10, and the heating temperature is 50-70 ℃.
Furthermore, the invention provides a preparation method of the composition with whitening effect, which comprises the following steps:
(1) adding glycerol and bisabolol in the formula amount into water, and performing ultrasonic treatment until the glycerol and the bisabolol are completely dissolved to obtain a mixture 1;
(2) and (2) cooling the mixture 1 obtained in the step (1), adding the centella asiatica extract, the verbena extract and the tea extract according to the formula amount, stirring, and homogenizing to obtain the composition with the whitening effect.
Preferably, in the step (1), the ultrasonic temperature is 50-60 ℃, and the ultrasonic power is 70-120W.
Preferably, in the step (2), the temperature for reducing the temperature is 35-40 ℃.
Preferably, in the step (2), the stirring time is 30-50 min.
Preferably, in the step (2), the time of the homogenization treatment is 0.5-1 h.
Finally, the invention provides application of the composition with the whitening effect in preparing skin care products.
Wherein the skin care product is at least one of toner, smoothing toner, firming toner, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleaning foam, cleaning water, facial mask, pressed powder, body lotion, body cream, body oil and body milk.
The invention has the beneficial effects that:
the invention provides a composition with whitening effect, which has good whitening effect; the formula composition is simple, and the safety is high; the mullein extract and the tea extract are compounded, so that the inhibition effect on tyrosinase is improved; meanwhile, the product has high stability and is convenient to store and transport; the raw materials have wide sources, the preparation method is simple, and the application prospect is good.
Detailed Description
The present invention will be further explained with reference to specific examples in order to make the technical means, the technical features, the technical objectives and the effects of the present invention easier to understand, but the following examples are only preferred embodiments of the present invention, and not all embodiments of the present invention. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative efforts belong to the protection scope of the present invention. In the following examples, unless otherwise specified, all the operations were performed by conventional methods, all the equipments were performed by conventional methods, and the materials of the equipments used in the respective examples were the same. The water used was deionized water.
The preparation method of the tea extract comprises the following steps: placing green tea in 70% ethanol, heating to 70 deg.C, extracting for 3 times, the material-liquid ratio is 1: centrifuging for 15min for 40min each time, collecting supernatant, and evaporating to remove solvent to obtain folium Camelliae sinensis extract.
The preparation method of the centella extract comprises the following steps: the asiatic pennywort herb leaves are placed in 70% ethanol and heated to 35 ℃ for extraction for 3 times, and the material-liquid ratio is 1: 10, centrifuging for 15min each time for 1h, collecting and combining the supernatant, and evaporating to remove the solvent to obtain the centella asiatica extract for later use.
The preparation method of the mullein extract comprises the following steps: extracting herba Verbasci Thapsi with 50% methanol at room temperature for 1h, at a material-to-liquid ratio of 1: 10, heating the extracting solution in water bath at 60 ℃ until the extracting solution is concentrated to 1/5 of the original volume, and obtaining the mullein extract for later use.
Example 1 preparation of the composition
(1) Adding glycerol and bisabolol in the formula amount into water, and performing ultrasonic treatment until the glycerol and the bisabolol are completely dissolved to obtain a mixture 1; the ultrasonic temperature is 55 ℃, and the ultrasonic power is 100W;
(2) cooling the mixture 1 obtained in the step (1) to 35-40 ℃, adding the centella asiatica extract, the verbena extract and the tea extract according to the formula dosage, stirring for 40min, and homogenizing for 1h to obtain the composition with the whitening effect.
The specific formulation is shown in the following table:
table 1.
Figure BDA0003638021860000041
Figure BDA0003638021860000051
Result detection
1. Safety test
The human skin closed patch test was performed according to the human skin patch test specified in the technical standards for cosmetic safety (2015 edition). 35 volunteers were selected, and no suspicious reaction or positive reaction was found in all of the products A to N of the formula of the present invention, which proved that the product of the present invention is safe and has no adverse reaction.
2. And (3) stability detection:
the detection method comprises the following steps: cold and hot test in turn, seal the storage 24h at 45 ℃, 25 ℃, 15 ℃ with the gained product in proper order, circulate 5 times after, place 12h at 25 ℃, thin scribble the product on the black observation board with the corresponding product of the new preparation of the same method, compare the outward appearance, the classification is as follows:
table 2.
Color (transparency) Precipitation of Layering Uniformity of smearing (compare with original product)
0 Without change Is free of Is free of Are identical to each other
1 Slight changes Small amount and difficult discrimination Slight delamination Slight unevenness of application
2 Is obviously changed Obvious precipitation Apparent delamination Obviously difficult to be evenly coated
The test results are as follows:
table 3.
Recipe number Colour(s) Precipitation of Layering Uniformity of application
A 0 0 0 0
B 0 0 0 0
C 0 0 0 0
D 0 0 0 0
E 0 0 0 0
F 0 0 0 0
G 0 0 0 0
H 0 0 0 0
I 0 0 0 0
J 0 0 0 0
K 0 0 0 0
L 0 0 0 0
M 0 0 0 0
N 0 0 0 0
The results in Table 3 show that the formulas A to N have good stability, and have no problems of precipitation, discoloration, delamination and the like after cold and hot alternation experiments.
3. Test of whitening Effect
3.1 detection method: tyrosinase inhibition assay
The enzymatic reaction converts L-dopa to a red dopaquinone, which has a maximum absorption at 475 nm. When tyrosinase and whitening active ingredients exist simultaneously, the catalytic activity of the tyrosinase can be inhibited to a certain degree, so that the generation of dopaquinone is reduced. Therefore, the absorbance at 475nm is measured by a spectrophotometer, the concentration of the generated dopaquinone can be reflected, and the inhibition degree of the composition on the tyrosinase activity can be further judged.
Group I: 0.5mL of L-dopa solution (1.0mg/mL) +3.0mL of phosphate buffer (pH 6-7) +0.2mL of tyrosinase (250U/mL) was placed in a 32 ℃ water bath.
Group II: 0.2mL tyrosinase (250U/mL) +3.5mL phosphate buffer (pH 6-7).
Group III: 0.5mL of L-dopa solution +3.0mL of the formulation composition solution (one set for each formulation separately) +0.2mL of tyrosinase (250U/mL) was placed in a 32 ℃ water bath.
Group IV: 3.0mL of the formulation solution +0.5mL of phosphate buffer (pH 6-7) +0.2mL of tyrosinase (250U/mL).
The absorbance at 475nm 1min after the start of the reaction (the absorbance of groups I, II, III, and IV was X, respectively) I 、X II 、X III 、X IV ) According toThe following formula calculates the tyrosinase inhibition rate for each set of formulations.
Tyrosinase inhibition rate ═ 1- (X) III -X IV )/(X I -X II )]×100%
Table 4.
Recipe number Tyrosinase inhibition (%)
A 16.7
B 45.7
C 45.1
D 44.8
E 47.5
F 49.6
G 69.7
H 68.8
I 69.1
J 17.2
K 30.4
L 75.2
M 78.9
N 74.3
The results in table 4 show that the formula G-I, L-N has a higher inhibitory effect on tyrosinase activity, and compared with the case where only the tea extract group B and only the mullein extract J are added, the case where both the tea extract and the mullein extract are added can significantly improve the inhibitory effect on tyrosinase. Meanwhile, on the premise of adding 5% of tea extract, the addition amount of the mullein extract is stably improved from 0.3%, and has a synergistic improvement effect when the addition amount is 1%, and the addition of the 5% of tea extract and the 1% of mullein extract is most suitable for batch production and application by comprehensively considering the raw material cost and the product effect.
3.2 detection method: melanin inhibition assay
140 volunteers aged 25-35 and women with obvious blotches on their faces were selected and randomly divided into 14 groups of 10 each using the products prepared according to formulas A-N. The product is applied on face uniformly, and is flapped to be absorbed completely, and is used once every day, 1.5mL each time, and continuously for three weeks without other skin care products. The skin melanin value was measured with a skin melanin measuring instrument (Courage Khazaka) before and after one week of use (average value was taken after selecting three parts of eye tail, cheek and forehead). The test of the same subject is carried out by the same instrument and the same tester. Before each measurement, the probe is cleaned, and meanwhile, the tested person washes the face with clear water, keeps relaxing, sits still for 10min, and receives the test.
Melanin inhibition rate (pre-use melanin value-post-use melanin value)/pre-use melanin value × 100%
The melanin inhibition was calculated for each individual group and averaged, and the results are given in the following table:
table 5.
Recipe number Melanin inhibition ratio (%)
A 2.7±0.8
B 6.7±3.7
C 6.5±3.1
D 7.0±2.3
E 6.9±1.2
F 7.4±3.4
G 11.3±2.5
H 10.7±1.9
I 11.6±2.8
J 2.3±1.0
K 4.4±1.5
L 11.6±4.4
M 13.9±2.6
N 9.8±3.2
The results of table 5 are the same trend as table 4, demonstrating that the whitening composition of the present invention has good practical use effect.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (10)

1. The composition with the whitening effect is characterized by comprising the following components: glycerin, tea leaf extract, mullein extract, centella asiatica extract, bisabolol, and water.
2. The composition with whitening efficacy according to claim 1, characterized by comprising the following components in percentage by weight: 10-25% of glycerin, 5-15% of tea extract, 0.3-2% of mullein extract, 2-10% of centella extract, 0.5-2% of bisabolol and water.
3. The composition with whitening efficacy according to claim 1 or 2, wherein the weight amount of the tea extract is more than five times of that of the mullein extract.
4. The composition with whitening effect according to claim 3, characterized by comprising the following components in percentage by weight: 20% of glycerin, 5% of tea extract, 1% of mullein extract, 4% of centella asiatica extract, 1% of bisabolol and water.
5. The composition with whitening efficacy according to claim 1, wherein the preparation method of the tea extract comprises: extracting folium Camelliae sinensis with ethanol for 1-3 times, centrifuging, collecting supernatant, and removing solvent to obtain folium Camelliae sinensis extract; the preparation method of the mullein extract comprises the following steps: extracting herba Verbasci Thapsi with methanol, and heating and concentrating the extractive solution to 1/5 to obtain herba Verbasci Thapsi extract.
6. The method for preparing the composition having whitening efficacy according to any one of claims 1 to 5, comprising the steps of:
(1) adding glycerol and bisabolol in the formula amount into water, and performing ultrasonic treatment until the glycerol and the bisabolol are completely dissolved to obtain a mixture 1;
(2) and (2) cooling the mixture 1 obtained in the step (1), adding the centella asiatica extract, the verbena extract and the tea extract according to the formula amount, stirring, and homogenizing to obtain the composition with the whitening effect.
7. The preparation method according to claim 6, wherein in the step (1), the ultrasonic temperature is 50-60 ℃ and the ultrasonic power is 70-120W.
8. The preparation method according to claim 6, wherein in the step (2), the temperature of the temperature reduction is 35-40 ℃, the stirring time is 30-50min, and the homogenization treatment time is 0.5-1 h.
9. Use of the composition with whitening effect according to any one of claims 1 to 5 in the preparation of skin care products.
10. The use of claim 9, wherein the skin care product is at least one of a toner, a firming lotion, a nourishing cream, a massage cream, a essence, an eye cream, a cleansing foam, a cleansing lotion, a mask, a pack, a body lotion, a body cream, a body oil, and a body milk.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116270357A (en) * 2023-04-07 2023-06-23 诺德溯源(广州)生物科技有限公司 Rapid brightening skin care composition and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103845237A (en) * 2014-02-13 2014-06-11 上海珍馨化工科技有限公司 Whitening body lotion
CN112006959A (en) * 2020-09-15 2020-12-01 上海应用技术大学 Antioxidant whitening cream containing dandelion and tea extracts and preparation method thereof
CN113425622A (en) * 2021-07-27 2021-09-24 江苏巴帝恩生物科技有限公司 A cosmetic raw material composition with skin whitening and antiallergic effects, and cosmetic containing the same
CN113509400A (en) * 2021-08-12 2021-10-19 广州集妍化妆品科技有限公司 Skin composition and application thereof, whitening and brightening cosmetic composition and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103845237A (en) * 2014-02-13 2014-06-11 上海珍馨化工科技有限公司 Whitening body lotion
CN112006959A (en) * 2020-09-15 2020-12-01 上海应用技术大学 Antioxidant whitening cream containing dandelion and tea extracts and preparation method thereof
CN113425622A (en) * 2021-07-27 2021-09-24 江苏巴帝恩生物科技有限公司 A cosmetic raw material composition with skin whitening and antiallergic effects, and cosmetic containing the same
CN113509400A (en) * 2021-08-12 2021-10-19 广州集妍化妆品科技有限公司 Skin composition and application thereof, whitening and brightening cosmetic composition and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王亮著, 东南大学出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116270357A (en) * 2023-04-07 2023-06-23 诺德溯源(广州)生物科技有限公司 Rapid brightening skin care composition and application thereof
CN116270357B (en) * 2023-04-07 2023-11-03 诺德溯源(广州)生物科技有限公司 Rapid brightening skin care composition and application thereof

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