CN111671685A - Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof - Google Patents
Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof Download PDFInfo
- Publication number
- CN111671685A CN111671685A CN202010543608.4A CN202010543608A CN111671685A CN 111671685 A CN111671685 A CN 111671685A CN 202010543608 A CN202010543608 A CN 202010543608A CN 111671685 A CN111671685 A CN 111671685A
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- Prior art keywords
- whitening
- freckle
- cream
- skin
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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Abstract
The invention discloses a whitening and freckle-removing composition, a whitening and freckle-removing cream and a preparation method thereof. The whitening and freckle-removing composition comprises the following components in percentage by mass (1-5): (1-3): (0.3-2): (0.4-2) the nicotinamide, the 4-butyl resorcinol, the lysate of the yeast fermentation product of the secondary cracking yeast and the extract of the daisy flower have synergistic effect, so that the whitening and freckle removing effects are greatly enhanced, an efficient and comprehensive whitening and freckle removing composition is formed, the comprehensive, rapid and lasting whitening and freckle removing effects can be realized on skin, and the whitening and freckle removing effects are good. The whitening and freckle-removing cream is based on the whitening and freckle-removing composition, has comprehensive, rapid and lasting whitening and freckle-removing effects, and is good in stability, durable and durable. The preparation method controls the preparation process according to the characteristics of the raw material components in the whitening and freckle-removing cream, so that the whitening and freckle-removing cream with uniform dispersed texture and good stability can be prepared, and the skin feeling is easy to apply and paste on the skin.
Description
Technical Field
The invention relates to the technical field of daily cosmetics, in particular to a whitening and freckle-removing composition, a whitening and freckle-removing cream and a preparation method thereof.
Background
Whitening is the pursuit of numerous female siblings, and cosmetics with whitening are always necessary for consumers of vast girls and are the focus of attention of cosmetic researchers and production operators. In the whitening process, the improvement of skin color is usually accompanied with the spot removal, and the whitening spot removal cream is the skin emulsion cream which has the effects of inhibiting, dissolving and removing the tarnish skin, uneven skin color and spots on the surface of the skin.
There are many reasons for the skin complexion and color spots, but the uncovering of melanin after rooting is an irrevocable source of malignancy. Melanin is mainly produced by melanocytes of the basal layer of the epidermis of the human body, wherein, under the influence of factors such as pollution of the external environment (illumination, etc.), living pressure, and the increase with age, the balance of metabolism of the human body is destroyed, the supply of nutrients required by the skin tends to be slow, the melanocytes become very active, the activity of tyrosinase is activated, the dendritic growth of the melanocytes accelerates the synthesis of melanin and the migration of melanosomes to keratinocytes, and melanin granules transferred to the keratinocytes move upwards to the stratum corneum along with the epidermal cells, thereby influencing the color of the skin or forming color spots. Therefore, it is necessary to consider the problems of skin color and color unevenness from many aspects.
At present, most of the whitening and freckle-removing products on the market have incomplete functions, and all links of skin whitening and freckle removing cannot be comprehensively considered. Or only pay attention to whitening and spot removing on the surface, the aim of removing pigment and spots deposited on the surface is achieved through removing the horny layer, the problem of whitening and spot removing cannot be fundamentally solved, the phenomenon of blackening occurs soon after the product is stopped, and the skin becomes sensitive and more skin is bred. Or, the whitening and freckle removing effects cannot be rapidly and comprehensively achieved by over-focusing on the source of melanin and the inhibition of transfer channels, and the added functional preparations are excessive or are forbidden components, so that the side effects are great, other skin diseases are induced, and the effect is counterproductive. In addition, the whitening and freckle-removing product is directly used on the skin of a human face, so that the whitening and freckle-removing product is required to have good and comprehensive whitening and freckle-removing effects, is mild and comfortable, prevents skin allergy to cause more serious skin problems, can effectively prevent external stimulation to the skin, and enables whitening and freckle removal to be more comprehensive and lasting, and is often ignored in the existing whitening and freckle-removing product.
Disclosure of Invention
The invention aims to provide a whitening and freckle-removing composition aiming at the defects or shortcomings in the prior art. The whitening and freckle-removing composition has efficient whitening and freckle-removing effects, and can achieve comprehensive, rapid and lasting whitening and freckle-removing effects on skin.
The invention also aims to provide whitening and freckle-removing cream based on the whitening and freckle-removing composition. The whitening and freckle-removing cream is based on the whitening and freckle-removing composition, can realize comprehensive, rapid and lasting whitening and freckle removal on skin, is good in skin feel, mild and comfortable, can effectively prevent external stimulation on skin, and enables the whitening and freckle-removing effect to be more comprehensive and lasting.
The invention also aims to provide a method for preparing the whitening and freckle-removing cream. The method controls the preparation process according to the characteristics of each raw material component in the whitening and freckle-removing cream, and the whitening and freckle-removing cream with uniform texture dispersion and good stability can be prepared.
The purpose of the invention is realized by the following technical scheme.
A whitening and freckle removing composition comprises (1-5) by mass: (1-3): (0.3-2): (0.4-2) nicotinamide, 4-butylresorcinol, a split yeast fermentation product lysate, and a daisy extract.
In a preferred embodiment, the whitening and freckle-removing composition comprises the following components in a mass ratio of (1.2-2.8): (1-1.8): (0.3-1.8): (0.6-1.2) nicotinamide, 4-butylresorcinol, a split yeast fermentation product lysate, and a daisy flower extract.
The whitening and freckle-removing cream comprises the following components in percentage by mass:
2.5-14% of emulsifier, 0.1-0.5% of thickener I, 2-6% of thickener II, 0.3-1% of thickener III, 4-20% of emollient, 3.02-18.2% of humectant, 0.05-0.18% of disodium EDTA (ethylene diamine tetraacetic acid), 4.24-13.6% of whitening and freckle removing composition, 0.1-1% of soybean lecithin, 0.02-0.5% of carboxymethyl chitosan, 0.02-0.1% of sodium bisulfite, 0.55-2.2% of antioxidant and the balance of water;
the whitening and freckle-removing composition is any one of the whitening and freckle-removing compositions.
In a preferred embodiment, the carboxymethyl chitosan is added in an amount of 0.02 to 0.08%.
In a preferred embodiment, the addition amount of the sodium sulfite is 0.02-0.08%.
In a preferred embodiment, the emulsifier comprises 1-5% of steareth-2, 1-5% of steareth-21 and 0.5-4% of PEG-100 stearate by mass percent.
In a preferred embodiment, the thickening agent I comprises 0.1-0.5% of xanthan gum by mass percentage.
In a preferred embodiment, the thickener II comprises 2-6% of polyethylene by mass percentage.
In a preferred embodiment, the thickener III comprises 0.3-1% of a compound of sodium acrylate/sodium acryloyldimethyl taurate copolymer, mineral oil and tridecyl alcohol polyether-6 in percentage by mass;
in the compound of the sodium acrylate/sodium acryloyldimethyl taurate copolymer, the mineral oil and the tridecyl alcohol polyether-6, the mass ratio of the sodium acrylate/sodium acryloyldimethyl taurate copolymer to the mineral oil to the tridecyl alcohol polyether-6 is 3: 1: 2.
in a preferred embodiment, the emollient comprises 1-6% cetearyl alcohol, 1-4% dimethicone, 1-5% isopropyl palmitate, and 1-5% caprylic/capric triglyceride by weight.
In a preferred embodiment, the humectant comprises 1-9% of polyglycerol-10, 0.02-0.2% of sodium hyaluronate and 2-9% of butanediol by mass percentage.
In a preferred embodiment, the antioxidant comprises 0.5-2% of tocopherol and 0.05-0.2% of butylated hydroxytoluene in percentage by mass.
In a more preferable embodiment, the addition amount of the tocopherol is 0.5-0.8%.
In a preferred embodiment, the method further comprises the following steps by mass percent: 0.05-0.3% of anti-allergic agent, 0.2-1% of sun-screening agent, 0.29-1.15% of preservative and 0.2-0.8% of coloring agent.
More preferably, the anti-sensitivity agent comprises allantoin.
More preferably, the sunscreen agent comprises ethylhexyl methoxycinnamate.
More preferably, the preservative comprises one or more of methylparaben, propylparaben, caprylyl hydroxamic acid, and phenoxyethanol.
More preferably, the colorant comprises CI 19140.
The method for preparing the whitening and freckle-removing cream comprises the following steps:
s1, uniformly dissolving 4-butyl resorcinol in the whitening and freckle-removing composition by using a part of humectant for later use;
s2, mixing the thickening agent I, the rest humectant, the EDTA disodium, the water and the nicotinamide in the whitening and freckle removing composition, heating to 80-85 ℃, stirring, homogenizing and dissolving uniformly;
s3, mixing the emulsifier, the emollient, the thickener II and the antioxidant, heating to 80 ℃, and dissolving uniformly;
s4, adding the components dissolved uniformly in the S3 into the components dissolved uniformly in the S2 at the temperature of 80-85 ℃, stirring for 3 minutes at 500-800 r/min, and homogenizing for 5 minutes at 2500-2800 r/min; vacuumizing, preserving heat, stirring for 15 minutes at the speed of 800-1000 r/min, removing vacuum, and continuously stirring for cooling;
s5, cooling to 70-75 ℃, adding a thickening agent III, continuously stirring for 5 minutes, homogenizing for 2 minutes at 1000-1200 r/min, and continuously stirring and cooling;
s6, cooling to 60-65 ℃, adding the 4-butylresorcinol dissolved in the S1, continuously stirring for 5 minutes, homogenizing for 2 minutes at 1000-1200 r/min, and continuously stirring and cooling;
s7, cooling to 40-45 ℃, adding the rest components of the whitening and freckle-removing composition, and continuously stirring uniformly; discharging to obtain the whitening and freckle-removing cream.
Compared with the prior art, the invention has the following advantages and beneficial effects:
in the whitening and freckle-removing composition, nicotinamide can accelerate the exfoliation of keratin containing melanocytes, 4-butylresorcinol can inhibit enzymes necessary for the generation of melanin, the lysate of the yeast fermentation product of bifida has the effect of enhancing the metabolism of the horny layer of skin, the daisy extract can brighten the skin color and enhance the endocytosis capacity of cells to melanin, and the nicotinamide, 4-butylresorcinol, the lysate of the yeast fermentation product of bifida and the daisy extract are compounded according to a specific mass ratio, so that the components are synergistic with each other, the whitening and freckle-removing effects are greatly enhanced, the efficient and comprehensive whitening and freckle-removing composition is formed, the comprehensive, rapid and lasting whitening and freckle-removing effects can be realized on the skin, and the whitening and freckle-removing effects are good.
Moreover, the daisy extract also has good external irritation resistance and antibacterial property, has strong relieving effect, and can make the whitening and freckle-removing composition have better, more comprehensive and lasting effects. In addition, the lysate of the yeast fermentation product of the bifida further has the effects of resisting aging, brightening skin color, relieving skin sensitivity, improving wrinkles and the like, so that the whitening and freckle-removing composition can be used for whitening and removing freckles, and simultaneously, the skin can be deeply improved synchronously, so that the skin is whitened, fine and active.
In the whitening and freckle-removing cream, the whitening and freckle-removing composition is used as a basis, so that the whitening and freckle-removing cream has comprehensive, rapid and lasting whitening and freckle-removing effects and an excellent whitening effect; in addition, the added emollient and humectant enables the whitening and freckle-removing cream to have good skin-care effect and good skin feeling after being coated, and the whitening and freckle-removing cream can moisten and moisturize and effectively care the skin. Meanwhile, the added carboxymethyl chitosan has good anti-allergy relieving effect, and has synergistic effect with the daisy extract in the whitening and freckle removing composition, so that the anti-allergy relieving effect is greatly increased, the irritation of the phenol raw materials to skin is effectively relieved, the use is safer and milder, and the durability of the whitening and freckle removing effect can be further improved.
In addition, under the synergistic action of the compatible emulsifier and the compatible thickener, and by the coordination of various added antioxidants, the discoloration and instability of the cream are effectively reduced, so that the cream has a better quality guarantee effect and is durable.
The preparation method controls the preparation process according to the characteristics of the raw material components in the whitening and freckle-removing cream, so that the whitening and freckle-removing cream with uniform dispersed texture and good stability can be prepared, and the skin feeling is easy to apply and paste on the skin.
Detailed Description
The technical solution of the present invention is further described in detail with reference to the following specific examples, but the scope and implementation of the present invention are not limited thereto. The present invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Also, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The whitening and freckle-removing composition provided by the embodiment of the invention comprises the following components in percentage by mass (1-5): (1-3): (0.3-2): (0.4-2) nicotinamide, 4-butylresorcinol, a split yeast fermentation product lysate, and a daisy flower extract.
In a preferred embodiment, the whitening and freckle-removing composition comprises the following components in percentage by mass (1.2-2.8): (1-1.8): (0.3-1.8): (0.6-1.2) nicotinamide, 4-butylresorcinol, a lysate of a fermentation product of a yeast schizosaccharomyces cerevisiae, and a marguerite extract.
The nicotinamide has small molecular weight, can be directly absorbed by epidermal cells, excites weakened cell activity, promotes the synthesis of collagen, prevents melanin from being excessively deposited, and achieves the effect of whitening. After melanin production, the skin turns dark only if it is transported to the stratum corneum. Nicotinamide can reduce the transfer of melanin to the stratum corneum of the skin, and nicotinamide can accelerate metabolism and accelerate the exfoliation of the horny layer containing melanocytes, thereby reducing the deposition of melanin in the stratum corneum and avoiding the darkening of the skin.
4-butylresorcinol is capable of interfering with the synthesis and glycosylation of tyrosinase prior to melanin synthesis, preventing the enzyme from being absorbed by melanosomes; during the synthesis of melanin, as a competitive inhibitor of tyrosinase and 5, 6-dihydroxyindole-2-carboxylic acid-oxidase, which are necessary for the production of melanin, the activity of tyrosinase and 5, 6-dihydroxyindole-2-carboxylic acid-oxidase can be inhibited, and the formation of byproducts which promote the production of melanin is reduced; thereby playing the role of inhibiting the generation of melanin, radically reducing the skin melanin and radically improving the skin complexion. And after melanin synthesis, the composition can improve tyrosinase degradation and inhibit the transfer of melanosomes to keratinocytes.
The lysate of the yeast fermentation product has strong anti-immunosuppression activity, can promote DNA repair, can effectively protect the skin, is not damaged by ultraviolet rays, helps to prevent the photoaging of epidermis and dermis, thereby reducing the generation of melanin caused by the stimulation of skin melanocyte and brightening the skin color. In addition, the skin whitening cream can also strengthen the metabolism of the horny layer, so that the horny layer cells deposited with melanin are exfoliated, and further achieve the effects of whitening and removing freckles. In addition, the zymolyte of the yeast bifida ferment can generate small molecules which comprise vitamin B group, mineral substances, amino acids and the like and are beneficial to skin care, has a good skin care effect, can capture free radicals, inhibits lipid peroxidation, and has the functions of resisting aging, relieving skin sensitivity and improving wrinkles.
The daisy extract is used as a plant whitening and brightening agent, can safely and effectively whiten the skin, can increase the endocytosis capacity of cells to melanin, prevents blackening after being stopped, and has strong relieving effect and bacteriostasis to external stimulation.
The whitening and freckle-removing composition is prepared by compounding nicotinamide, 4-butylresorcinol, the lysate of the yeast fermentation product of the bifida and the extract of the daisy flower according to a specific mass ratio, so that the components are synergistic, the comprehensive skin color improvement is performed from the prevention of melanin generation, the inhibition of melanin transfer, the metabolism of stratum corneum cells deposited with melanin and the like, the whitening and freckle-removing effects are greatly enhanced, the efficient and comprehensive whitening and freckle-removing composition is formed, and the comprehensive, rapid and lasting whitening and freckle-removing effects and the good whitening and freckle-removing effects can be realized on the skin.
The whitening and freckle-removing cream provided by the embodiment of the invention comprises the following components in percentage by mass:
2.5-14% of emulsifier, 0.1-0.5% of thickener I, 2-6% of thickener II, 0.3-1% of thickener III, 4-20% of emollient, 3.02-18.2% of humectant, 0.05-0.18% of disodium EDTA (ethylene diamine tetraacetic acid), 4.24-13.6% of whitening and freckle removing composition, 0.1-1% of soybean lecithin, 0.02-0.5% of carboxymethyl chitosan, 0.02-0.1% of sodium bisulfite, 0.55-2.2% of antioxidant and the balance of water;
the whitening and freckle-removing composition is the whitening and freckle-removing composition.
The whitening and freckle-removing cream is based on the whitening and freckle-removing composition, has comprehensive, rapid and lasting whitening and freckle-removing effects, and is excellent in whitening effect; in addition, the added emollient and humectant enables the whitening and freckle-removing cream to have good skin-care effect and good skin feeling after being coated, and the whitening and freckle-removing cream can moisten and moisturize and effectively care the skin. Meanwhile, the added soybean lecithin has good cell transfer capacity enhancement, has good synergistic effect with the whitening and freckle-removing composition, and can effectively promote the skin improvement effect of the whitening and freckle-removing composition; the added carboxymethyl chitosan has good anti-allergy relieving effect, and has synergistic effect with the daisy extract in the whitening and freckle removing composition, so that the anti-allergy relieving effect is greatly increased, the irritation of the phenol raw materials to skin is effectively relieved, the use is safer and milder, and the durability of the whitening and freckle removing effect can be further improved.
In a preferred embodiment, the emulsifier comprises 1-5% of steareth-2, 1-5% of steareth-21 and 0.5-4% of PEG-100 stearate by mass percent.
In a preferred embodiment, the thickening agent I comprises 0.1-0.5% of xanthan gum by mass percentage.
In a preferred embodiment, the thickener II comprises 2-6% of polyethylene by mass percentage.
In a preferred embodiment, the thickener III comprises 0.3-1% of a compound of sodium acrylate/sodium acryloyldimethyl taurate copolymer, mineral oil and tridecyl alcohol polyether-6 in percentage by mass;
in the compound of the sodium acrylate/sodium acryloyldimethyl taurate copolymer, the mineral oil and the tridecyl alcohol polyether-6, the mass ratio of the sodium acrylate/sodium acryloyldimethyl taurate copolymer to the mineral oil to the tridecyl alcohol polyether-6 is 3: 1: 2.
in a preferred embodiment, the emollient comprises 1-6% cetearyl alcohol, 1-4% dimethicone, 1-5% isopropyl palmitate, and 1-5% caprylic/capric triglyceride by weight.
In a preferred embodiment, the humectant comprises 1-9% of polyglycerol-10, 0.02-0.2% of sodium hyaluronate and 2-9% of butanediol by mass percentage.
In a preferred embodiment, the antioxidant comprises 0.5-2% of tocopherol and 0.05-0.2% of butylated hydroxytoluene in percentage by mass.
The tocopherol has good antioxidation, and can resist oxidation to protect cells from being poisoned by free radicals; the butylated hydroxytoluene has strong oxidation resistance, good heat resistance and stability, and also has antibacterial effect. Under the synergistic effect of the compatible emulsifier and thickener, and the coordination of the added tocopherol and the butylated hydroxytoluene antioxidant, the discoloration and instability of the cream are effectively reduced, so that the cream has better quality-guaranteeing effect and is durable.
In a preferred embodiment, the method further comprises the following steps by mass percent: 0.05-0.3% of an anti-allergic agent; and/or 0.2-1% of a sun-screening agent; and/or 0.29-1.15% of preservative; and/or 0.2-0.8% of a coloring agent. The addition of the anti-allergic agent ensures that the whitening and freckle-removing cream does not stimulate the skin when in use, and is mild and comfortable; the addition of the sun-screening agent enables the whitening and freckle-removing cream to further increase the effect of resisting external stimulation of skin, thereby being beneficial to better whitening and freckle removal; the paste of the whitening and freckle-removing cream has a better quality-guaranteeing effect and is durable for a long time.
Wherein, in a more preferred embodiment, the anti-sensitivity agent comprises allantoin. The allantoin can be combined with various substances to form a compound salt, has the effects of shading, sterilizing, preventing corrosion, relieving pain and resisting oxidation, can increase a better anti-allergy effect for the whitening and freckle-removing cream, further effectively relieves the irritation of phenol raw materials to skin, and is safer and milder to use. Meanwhile, the allantoin also has good effects of moistening skin, repairing, moisturizing and softening stratum corneum, so that the skin is more moist, moisturized and glossy.
In a more preferred embodiment, the sunscreen agent comprises ethylhexyl methoxycinnamate.
In a more preferred embodiment, the preservative comprises one or more of methylparaben, propylparaben, caprylyl hydroxamic acid, and phenoxyethanol.
In a more preferred embodiment, the colorant comprises CI 19140.
The following describes embodiments of the present invention in detail with reference to specific examples.
Examples 1 to 6
The whitening and freckle-removing cream of the embodiments 1 to 6 comprises the raw materials in percentage by mass as shown in table 1.
Table 1 raw material composition (mass percentage, total 100%) of whitening and spot-removing cream of examples 1 to 6
The whitening and freckle-removing cream of the embodiments 1 to 6 is prepared according to the following method, and the specific steps are as follows:
s1, dissolving 4-butyl resorcinol uniformly by using butanediol for later use;
s2, mixing the thickening agent I, polyglycerol-10, sodium hyaluronate, EDTA disodium, water, allantoin and nicotinamide, heating to 80-85 ℃, stirring, homogenizing, and dissolving uniformly to obtain a water phase;
s3, mixing an emulsifier, an emollient, a thickener II, an antioxidant, a sunscreen agent, methylparaben and propylparaben, heating to 80 ℃, and dissolving uniformly to obtain an oil phase;
s4, adding the oil phase component dissolved uniformly in the S3 into the water phase component dissolved uniformly in the S2 at the temperature of 80-85 ℃, stirring for 3 minutes at 500-800 r/min, and homogenizing for 5 minutes at 2500-2800 r/min; vacuumizing, preserving heat, stirring for 15 minutes at the speed of 800-1000 r/min, removing vacuum, and continuously stirring for cooling;
s5, cooling to 70-75 ℃, adding a thickening agent III, continuously stirring for 5 minutes, homogenizing for 2 minutes at 1000-1200 r/min, and continuously stirring and cooling;
s6, cooling to 60-65 ℃, adding the 4-butylresorcinol dissolved in the S1, continuously stirring for 5 minutes, homogenizing for 2 minutes at 1000-1200 r/min, and continuously stirring and cooling;
s7, cooling to 40-45 ℃, adding soybean lecithin, caprylyl hydroximic acid, phenoxyethanol, a schizosaccharomyces cerevisiae fermentation product lysate, a daisy extract, carboxymethyl chitosan, sodium bisulfite and a colorant, and continuously stirring uniformly;
s8, cooling to below 40 ℃, and discharging to obtain the whitening and freckle-removing cream.
Comparative example 1
Compared with example 2, the whitening and freckle-removing cream of the comparative example does not contain 4-butyl resorcinol.
Comparative example 2
Compared with the example 2, the whitening and freckle removing cream of the comparative example does not contain the lysate of the yeast bifida ferment product.
Comparative example 3
Compared with example 2, the whitening and freckle-removing cream of the comparative example does not contain the daisy extract.
Comparative example 4
Compared with the example 2, the whitening and freckle removing cream of the comparative example does not contain the lysate of the yeast schizolysis product and the extract of the daisy.
Comparative example 5
Compared with example 2, the whitening and freckle-removing cream of the comparative example does not contain carboxymethyl chitosan.
Comparative example 6
Compared with the example 2, the whitening and freckle-removing cream of the comparative example does not contain soybean lecithin and carboxymethyl chitosan.
Comparative example 7
Compared with the embodiment 2, the whitening and freckle-removing cream of the comparative example does not contain tocopherol and butylated hydroxytoluene.
Comparative examples 1 to 7 the same preparation method as in example 2 was used to prepare the whitening and freckle-removing creams of comparative examples 1 to 7.
1. Stability test
The whitening and freckle-removing creams of examples 1 to 6 and comparative examples 1 to 7 were subjected to a cold-resistant and heat-resistant stability test, and a stability test by centrifugal separation was also performed, and the test results are shown in table 2.
Table 2 test results of appearance state and corresponding performance of the whitening and freckle-removing cream of examples 1 to 6 and comparative examples 1 to 7
As can be seen from table 2, the whitening and freckle-removing creams of the examples 1 to 6 and the comparative examples 1 to 6 have good cold-resistant and heat-resistant physicochemical properties, and compared with the whitening and freckle-removing cream of the comparative example 7, the cream has good stability and good quality guarantee effect. The whitening and freckle-removing cream disclosed by the invention is coordinated with various added antioxidants under the synergistic effect of the compatible emulsifier and the compatible thickener, so that the discoloration and instability of the cream are effectively reduced, and the cream has a better quality-guaranteeing effect and is durable.
2. Use test
1) Test of whitening and freckle-removing effects
65 female volunteers 25-35 years old, dark face complexion and colored spots are recruited, and the female volunteers are randomly divided into 13 groups by 5 persons; the 13 groups of volunteers were used in the morning and evening 2 times a day in each case in groups corresponding to the whitening and spot-removing creams of test examples 1 to 6 and comparative examples 1 to 7, respectively. The volunteers washed their faces with clear water before each application of the corresponding whitening and spot-removing cream.
After the volunteers use the corresponding whitening and freckle-removing cream for 0, 4 and 8 weeks, quantitative analysis and measurement are carried out on facial skin stains and melanin of the volunteers by using a visia skin detector, and the test results are shown in tables 4 and 5.
Table 4 test results of skin spots of the whitening and spot-removing creams of examples 1 to 6 and comparative examples 1 to 7 after 0, 4 and 8 weeks of use
TABLE 5 test results of skin melanin condition after 0, 4, and 8 weeks of use of the whitening and freckle-removing creams of examples 1 to 6 and comparative examples 1 to 7
As can be seen from tables 4 and 5, compared with the whitening and freckle-removing cream of comparative examples 1 to 7, the whitening and freckle-removing cream of examples 1 to 6 can significantly reduce skin color spots and melanin, effectively whiten skin and remove freckles, and has a lasting effect. The whitening and freckle-removing cream disclosed by the invention is based on a whitening and freckle-removing composition compounded by nicotinamide, 4-butyl resorcinol, a yeast fermentation product lysate and a daisy extract, has comprehensive, rapid and lasting whitening and freckle-removing effects, and is excellent in whitening effect.
2) Anti-wrinkle test
The Skin texture of the face of the volunteer who used the corresponding whitening spot-removing cream for 0 week, 4 weeks, and 8 weeks was measured (3 times by averaging) using a Skin image analysis system (Skin visualizer SV600), and the test results are shown in table 6.
Table 6 results of skin texture test of the whitening and spot-removing creams of examples 1 to 6 and comparative examples 1 to 7 after 0, 4 and 8 weeks of use
As can be seen from table 6, the whitening and spot-removing creams of examples 1 to 6 and comparative examples 1 to 6 also have good anti-wrinkle and skin-smoothing effects.
3) Skin feel score
According to the trial condition of the whitening and freckle-removing cream corresponding to each volunteer, the use experience sense and the irritation use experience are summarized, the use experience sense is scored (10 points, 10 points are fully scored, the scoring results of all groups are averaged according to the test values in the groups), and the summarized use experience effect is shown in table 7.
Table 7 use experience results of the whitening and freckle removing cream of examples 1 to 6 and comparative examples 1 to 7
In conclusion, the whitening and freckle-removing cream is based on a whitening and freckle-removing composition compounded by nicotinamide, 4-butyl resorcinol, a yeast fermentation product lysate and a daisy extract, has comprehensive, rapid and lasting whitening and freckle-removing effects, and is excellent in whitening effect; in addition, the added emollient and humectant enables the whitening and freckle-removing cream to have good skin-care effect and good skin feeling after being coated, and the whitening and freckle-removing cream can moisten and moisturize and effectively care the skin. Meanwhile, the added carboxymethyl chitosan has good anti-allergy relieving effect, and has synergistic effect with the daisy extract in the whitening and freckle removing composition, so that the anti-allergy relieving effect is greatly increased, the irritation of the phenol raw materials to skin is effectively relieved, the use is safer and milder, and the durability of the whitening and freckle removing effect can be further improved. In addition, under the synergistic action of the compatible emulsifier and the compatible thickener, and by the coordination of various added antioxidants, the discoloration and instability of the cream are effectively reduced, so that the cream has a better quality guarantee effect and is durable. Moreover, based on the preparation method of the invention, the whitening and freckle-removing cream with uniform and dispersed texture and good stability can be prepared, and the skin feeling is easy to push, smear and adhere to the skin.
Various technical features of the above embodiments may be combined arbitrarily, and for the sake of brevity, all possible combinations of the technical features of the above embodiments are not described in this specification. However, as long as there is no contradiction between combinations of these technical features, the scope of the present specification should be considered as being described. Furthermore, the above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The whitening and freckle-removing composition is characterized by comprising the following components in percentage by mass (1-5): (1-3): (0.3-2): (0.4-2) nicotinamide, 4-butylresorcinol, a split yeast fermentation product lysate, and a daisy extract.
2. The whitening and freckle-removing composition according to claim 1, which is characterized by comprising the following components in percentage by mass (1.2-2.8): (1-1.8): (0.3-1.8): (0.6-1.2) nicotinamide, 4-butylresorcinol, a split yeast fermentation product lysate, and a daisy flower extract.
3. The whitening and freckle-removing cream is characterized by comprising the following components in percentage by mass:
2.5-14% of emulsifier, 0.1-0.5% of thickener I, 2-6% of thickener II, 0.3-1% of thickener III, 4-20% of emollient, 3.02-18.2% of humectant, 0.05-0.18% of disodium EDTA (ethylene diamine tetraacetic acid), 4.24-13.6% of whitening and freckle removing composition, 0.1-1% of soybean lecithin, 0.02-0.5% of carboxymethyl chitosan, 0.02-0.1% of sodium bisulfite, 0.55-2.2% of antioxidant and the balance of water;
the whitening and freckle-removing composition is the whitening and freckle-removing composition in claim 1 or 2.
4. The cream of claim 3, wherein the emulsifier comprises, by mass, 1-5% steareth-2, 1-5% steareth-21, and 0.5-4% PEG-100 stearate.
5. The cream of claim 3, wherein the thickener I comprises 0.1-0.5% of xanthan gum, the thickener II comprises 2-6% of polyethylene, and the thickener III comprises 0.3-1% of a compound of sodium acrylate/sodium acryloyldimethyl taurate copolymer, mineral oil and tridecyl alcohol polyether-6;
in the compound of the sodium acrylate/sodium acryloyldimethyl taurate copolymer, the mineral oil and the tridecyl alcohol polyether-6, the mass ratio of the sodium acrylate/sodium acryloyldimethyl taurate copolymer to the mineral oil to the tridecyl alcohol polyether-6 is 3: 1: 2.
6. the cream of claim 3, wherein the emollient comprises, by mass, 1-6% of cetearyl alcohol, 1-4% of polydimethylsiloxane, 1-5% of isopropyl palmitate, and 1-5% of caprylic/capric triglyceride.
7. The whitening and freckle-removing cream according to claim 3, wherein the moisturizing agent comprises 1-9% of polyglycerol-10, 0.02-0.2% of sodium hyaluronate and 2-9% of butanediol by mass percent.
8. The cream of claim 3, wherein the antioxidant comprises 0.5-2% of tocopherol and 0.05-0.2% of butylated hydroxytoluene by mass.
9. The whitening and freckle-removing cream according to any one of claims 3 to 8, further comprising, by mass: 0.05-0.3% of anti-allergic agent, 0.2-1% of sun-screening agent, 0.29-1.15% of preservative and 0.2-0.8% of colorant;
the anti-sensitivity agent comprises allantoin; the sunscreen agent comprises ethylhexyl methoxycinnamate; the antiseptic comprises more than one of methyl hydroxybenzoate, propyl hydroxybenzoate, caprylyl hydroxamic acid and phenoxyethanol.
10. The method for preparing the whitening and freckle-removing cream according to claim 3 is characterized by comprising the following steps of:
s1, uniformly dissolving 4-butyl resorcinol in the whitening and freckle-removing composition by using a part of humectant for later use;
s2, mixing the thickening agent I, the rest humectant, the EDTA disodium, the water and the nicotinamide in the whitening and freckle removing composition, heating to 80-85 ℃, stirring, homogenizing and dissolving uniformly;
s3, mixing the emulsifier, the emollient, the thickener II and the antioxidant, heating to 80 ℃, and dissolving uniformly;
s4, adding the components dissolved uniformly in the S3 into the components dissolved uniformly in the S2 at the temperature of 80-85 ℃, stirring for 3 minutes at 500-800 r/min, and homogenizing for 5 minutes at 2500-2800 r/min; vacuumizing, preserving heat, stirring for 15 minutes at the speed of 800-1000 r/min, removing vacuum, and continuously stirring for cooling;
s5, cooling to 70-75 ℃, adding a thickening agent III, continuously stirring for 5 minutes, homogenizing for 2 minutes at 1000-1200 r/min, and continuously stirring and cooling;
s6, cooling to 60-65 ℃, adding the 4-butylresorcinol dissolved in the S1, continuously stirring for 5 minutes, homogenizing for 2 minutes at 1000-1200 r/min, and continuously stirring and cooling;
s7, cooling to 40-45 ℃, adding the rest components of the whitening and freckle-removing composition, and continuously stirring uniformly; discharging to obtain the whitening and freckle-removing cream.
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Application publication date: 20200918 |