CN110200874A - A kind of whitening and spot eliminating cream and preparation method thereof - Google Patents
A kind of whitening and spot eliminating cream and preparation method thereof Download PDFInfo
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- A61K8/67—Vitamins
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Abstract
The invention discloses the raw materials such as a kind of whitening and spot eliminating cream, including benzophenone-3, ethylhexyl methoxy cinnamate, niacinamide, Radix Sophorae Flavescentis extractive liquid, 4- butyl resorcinol, VC ethylether, Trenaxmine.And disclose preparation method.Whitening and spot eliminating cream of the present invention can inhibit tyrosinase, eliminate chloasma, free radical resisting, bright color, is not stimulated, is suitable for popularization and application using safe.
Description
Technical field
The present invention relates to cosmetic technical field, more particularly to a kind of whitening and spot eliminating cream and preparation method thereof.
Background technique
There are many whitening and freckle-removing product currently on the market, but its using effect is usually unsatisfactory, as kojic acid class nti-freckle produces
Product, Pyrogentisinic Acid's nti-freckle product, arbutin nti-freckle product, Symwhite-337 nti-freckle product etc. or freckle effect be not significant, or
Irritation is strong, Yi Zhimin, makes user daunting.
Therefore, how a kind of whitening spot-removing significant effect is provided, becomes this field using safe and non-stimulating skin-protection product
Technical problem urgently to be resolved.
Summary of the invention
In view of this, integrate nti-freckle, whitening, sun-proof, moisture-keeping functions the present invention provides a kind of whitening and spot eliminating cream,
The beauty reparation of skin is fast implemented, use is safe and non-stimulating.
To achieve the goals above, the present invention adopts the following technical scheme:
A kind of whitening and spot eliminating cream, based on parts by weight, including the following raw material:
Component A: 0.2-1 parts of benzophenone-3,1-3 parts of ethylhexyl methoxy cinnamate, 2-6 parts of emulsifier, moisturizing alcohol 2-5
Part, 10-15 parts of grease；
B component: 20-40 parts of water, 1-5 parts of niacinamide, 8-15 parts of Radix Sophorae Flavescentis extractive liquid, 2.35-6.65 parts of moisturizing thickener；
Component C: 0.5-2 parts of viscosity modifier；
D component: 0.5-1.5 parts of 4- butyl resorcinol, 5-10 parts of solvent；
Component E: 0.5-1.5 parts of VC ethylether, 1-5 parts of water；
F component: 0.5-1 parts of Trenaxmine, 1-5 parts of water；
G component: 0.05-0.2 parts of menthyl lactate, silk 1-1.5 parts of hydrolysis, 0.05-0.15 parts of phytic acid, antibacterial agent 1.2-
2.5 parts, 1-2 parts of plant desensitizer.
Niacinamide is a kind of derivative of vitamin B3, can reduce and prevent the skin that skin generates in early stage aging course
Color is dull, turns to be yellow, famished look, repairs impaired Stratum corneum lipids barrier, improves skin resistance, and have extremely strong water lock, guarantor
Wet effect.
VC ethylether can inhibit tyrosinase activity, inhibit the formation of melanin, reduction melanin is colourless, and is had
Potent antibacterial effect；Its stability is good, fast light, heat-resisting, acidproof, alkaline-resisting, salt tolerant and air oxidation, non-discolouring, easily absorbs, and enters
The synthesis of collagen is directly participated in after skin corium, repairs Skin Cell activity, so that skin be made to become full high resilience.
Trenaxmine is a kind of protease inhibitors, catalytic action of the energy protease inhibition to peptide bond hydrolysis, to prevent
Such as activity of rising property protease enzyme, and then the confusion of the epidermal cell function at blackspot position is inhibited, and inhibit black
Plain enhancement factor group, then thoroughly break off because ultraviolet light irradiate and formed melanin occur approach, thus effectively prevent and
Improve the pigment deposition of skin.
Kuh-seng is the dry root of leguminous plant kuh-seng, can be cleared away the dampness and heat, and pore is dredged and restrained to Bergamot Mint Extract,
Remove skin endotoxin contamination；Its herbal nutrition abundant, promotes the growth and reparation of damaged blood vessels nerve cell, restores subcutaneous
Capillary cells vigor, skin reproduction is compact fine and smooth, plays the role of beauty and skin care.
4- butyl resorcinol both can inhibit melanin pigmentation, lighten the stain, and can uvioresistant, anti-oxidant, infiltration
Fastly, highly-safe, sensitization is low.
The application, with given dose and VC ethylether, 4- butyl resorcinol compatible use, is mentioned using niacinamide, Trenaxmine
Its high inhibiting effect to melanin, be aided with Radix Sophorae Flavescentis extractive liquid effectively dispel it is obscure so that skin is brighter.
In addition, skin blackening, the generation of color spot intensification be a process, therefore, skin whitening not only need bright color,
It lightens the stain, prevention and treatment is also needed to combine；Benzophenone-3, ethylhexyl methoxy cinnamate are added in the application whitening and spot eliminating cream, it can
Effective Ultraviolet radiation absorbing, and then guarantee that whitening spot-removing ingredient plays its function to greatest extent.
Preferably, in component A: moisturizing alcohol is one of propylene glycol, 1,3-BDO, glycerol or a variety of；Grease is cream
One of the wooden fruit oil, SIMMONDSIA CHINENSIS SEED OIL are a variety of.
It is further preferred that moisturizing alcohol is propylene glycol, 1,3-BDO, glycerol with the mixing of 1:1:2 mass ratio.
Preferably, in B component: moisturizing thickener includes 0.05-0.15 parts of hyaluronic acid, 2-6 parts of glycerol and xanthan gum
0.3-0.5 parts.
Preferably, component C is polyacrylate cross-linked polymer -6.
Preferably, the solvent in D component is 1,3-BDO.
Preferably, in G component: antibacterial agent includes 0.5-1 parts of glycerol caprylate, 0.5-1 parts of Sensiva SC50 and benzene oxygen
0.2-0.5 parts of ethyl alcohol；Plant desensitizer include aloe extract, Baical Skullcap root P.E, Gotu Kola P.E, in green-tea extract
Any one or more.
The preparation method of above-mentioned whitening and spot eliminating cream, includes the following steps:
(1) each raw material of component A is weighed, is heated with stirring to 75-80 DEG C, oily phase is made, for use；
(2) when the water in B component being heated to 50-60 DEG C, niacinamide and Radix Sophorae Flavescentis extractive liquid is added, is heated to 75-80 DEG C,
It is mixed into moisturizing thickener, is stirred evenly, water phase is obtained；
(3) the oil phase is added to the aqueous phase, stirs cooling under vacuum after mixing；
(4) component C is added when being cooled to 65 DEG C, is uniformly mixed, at creams shape；
(5) continue stirring cooling under vacuum, D component, component E, F component is added when being cooled to 45 DEG C, is uniformly mixed；
(6) G component is added when being cooled to 40 DEG C, after mixing evenly filtering and discharging.
Whitening and spot eliminating cream is prepared by the above method, is avoiding loss of effective components simultaneously, guarantees that creams are more uniform steady
It is fixed.
Preferably, the moisturizing thickener in step (2) is pre-mixed uniformly；D component, component E, F component in step (5)
Sufficiently dissolution in advance respectively, is heated to 40-45 DEG C when wherein D component dissolves.
Preferably, homogeneous 5-10min is stirred under vacuum cooling again after oil is added to water phase in step (3)；It is added in step (4)
Homogeneous 2-3min after component C；D component, component E, F component are stirred in addition in step (5), mixing speed 20-30r/min,
Homogeneous 30s after having added.
Preferably, 80 mesh filter clothes were filtered into step (6).
Preferably, room temperature is aged for 24 hours after discharging.
As shown from the above technical solution, the present invention discloses a kind of whitening and spot eliminating cream and preparation method thereof, can inhibit junket ammonia
Sour enzyme, eliminate chloasma, free radical resisting, bright color are not stimulated using safe, and storage-stable is suitable for popularization and application.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
The traditional Chinese medicine extraction raw material being related to is as follows:
Radix Sophorae Flavescentis extractive liquid: Xun Nuo Chemical Industry Science Co., Ltd, Shantou City, YF16-037；Gotu Kola P.E: the green day in Xi'an
Bioisystech Co., Ltd, PBJ0101 are faint yellow；Aloe extract: Xi'an Lv Tian Bioisystech Co., Ltd, PBL0101；
Baical Skullcap root P.E: Xi'an Lv Tian Bioisystech Co., Ltd, PBH0101；Green-tea extract: the green limited public affairs of day biotechnology in Xi'an
Department, PMB1502.
Embodiment 1
A kind of whitening and spot eliminating cream, based on parts by weight, including the following raw material:
Component A: 0.5 part of benzophenone-3,1.5 parts of ethylhexyl methoxy cinnamate, 5 parts of stearine, propylene glycol 1
Part, 1 part of 1,3-BDO, 2 parts of glycerol, 15 parts of shea butter；
B component: 28.17 parts of water, 3 parts of niacinamide, 10 parts of Radix Sophorae Flavescentis extractive liquid, 0.08 part of hyaluronic acid, 6 parts of glycerol and xanthan
0.3 part of glue.
Component C: -61 parts of polyacrylate cross-linked polymer；
D component: 1 part of 4- butyl resorcinol, 8 parts of 1,3-BDO；
Component E: 1 part of VC ethylether, 5 parts of water；
F component: 0.5 part of Trenaxmine, 5 parts of water；
G component: 0.1 part of menthyl lactate, 1.5 parts of silk of hydrolysis, 0.05 part of phytic acid, 0.5 part of glycerol caprylate, ethyl hexyl
0.5 part of base glycerol, 0.3 part of Phenoxyethanol, aloe extract, Baical Skullcap root P.E, 1 part of Gotu Kola P.E, aloe extract 1
Part.
The preparation method of above-mentioned whitening and spot eliminating cream, includes the following steps:
(1) each raw material of component A is weighed, is heated with stirring to 80 DEG C, oily phase, heat preservation for standby use is made；
(2) hyaluronic acid is uniformly mixed using the glycerol in B component with xanthan gum, moisturizing thickener is made；By B component
In water when being heated to 55 DEG C, niacinamide and Radix Sophorae Flavescentis extractive liquid is added, continues to be heated to 80 DEG C, is mixed into moisturizing thickener, stirs
Uniformly, water phase is obtained；
(3) the oil phase is added to the aqueous phase, 3000r/min homogeneous 6min, and (30r/min) cooling is then stirred under vacuum；
(4) component C, 2000r/min homogeneous 3min, at creams shape are added when being cooled to 65 DEG C；
(5) continue to stir (30r/min) cooling under vacuum, be added when being cooled to 45 DEG C when stirring (30r/min) in advance
D component, component E, the F component sufficiently dissolved, uniformly mixed (D component, component E, F component dissolve in advance respectively, wherein D component
45 DEG C are heated to when dissolution)；
(6) G component is added when continuing to be cooled to 40 DEG C, crosses the discharging of 80 mesh filter clothes after mixing evenly, room temperature is aged after discharging
24h。
Embodiment 2
A kind of whitening and spot eliminating cream, based on parts by weight, including the following raw material:
Component A: 1 part of benzophenone-3,1 part of ethylhexyl methoxy cinnamate, 3 parts of citric acid fatty glyceride, the third two
3 parts of alcohol, 12 parts of SIMMONDSIA CHINENSIS SEED OIL；
B component: 30.85 parts of water, 5 parts of niacinamide, 15 parts of Radix Sophorae Flavescentis extractive liquid, 0.15 part of hyaluronic acid, 4 parts of glycerol, xanthan
0.4 part of glue.
Component C: -62 parts of polyacrylate cross-linked polymer；
D component: 1.5 parts of 4- butyl resorcinol, 10 parts of 1,3-BDO；
Component E: 0.5 part of VC ethylether, 3 parts of water；
F component: 0.5 part of Trenaxmine, 3 parts of water；
G component: 0.15 part of menthyl lactate, 1 part of silk of hydrolysis, 0.15 part of phytic acid, 0.8 part of glycerol caprylate, ethyl hexyl
0.8 part of base glycerol, 0.2 part of Phenoxyethanol, 0.5 part of Baical Skullcap root P.E, 0.5 part of green-tea extract.
The preparation method of above-mentioned whitening and spot eliminating cream, includes the following steps:
(1) each raw material of component A is weighed, is heated with stirring to 75 DEG C, oily phase, heat preservation for standby use is made；
(2) hyaluronic acid is uniformly mixed using the glycerol in B component with xanthan gum, moisturizing thickener is made；By B component
In water when being heated to 50 DEG C, niacinamide and Radix Sophorae Flavescentis extractive liquid is added, is heated to 75 DEG C, is mixed into moisturizing thickener, stirs evenly,
Obtain water phase；
(3) the oil phase is added to the aqueous phase, 2500r/min homogeneous 8min, and (20r/min) cooling is stirred under vacuum；
(4) component C, 2000r/min homogeneous 2min, at creams shape are added when being cooled to 65 DEG C；
(5) continue to stir (20r/min) cooling under vacuum, be added when being cooled to 45 DEG C when stirring (20r/min) in advance
D component, component E, the F component sufficiently dissolved, uniformly mixed (D component, component E, F component dissolve in advance respectively, wherein D component
40 DEG C are heated to when dissolution)；
(6) G component is added when being cooled to 40 DEG C, crosses the discharging of 80 mesh filter clothes after mixing evenly, room temperature is aged for 24 hours after discharging.
Embodiment 3
A kind of whitening and spot eliminating cream, based on parts by weight, including the following raw material:
Component A: 0.2 part of benzophenone-3,3 parts of ethylhexyl methoxy cinnamate, 6 parts of emulsifier, 2 parts of 1,3-BDO,
3 parts of propylene glycol, 5 parts of shea butter, 5 parts of SIMMONDSIA CHINENSIS SEED OIL；
B component: 31.6 parts of water, 2.5 parts of niacinamide, 8 parts of Radix Sophorae Flavescentis extractive liquid, 0.05 part of hyaluronic acid, 5 parts of glycerol and xanthan
0.5 part of glue.
Component C: -61.5 parts of polyacrylate cross-linked polymer；
D component: 1.2 parts of 4- butyl resorcinol, 8 parts of 1,3-BDO；
Component E: 1.5 parts of VC ethylether, 5 parts of water；
F component: 1 part of Trenaxmine, 5 parts of water；
G component: 0.15 part of menthyl lactate, 1.2 parts of silk of hydrolysis, 0.1 part of phytic acid, 1 part of glycerol caprylate, ethylhexyl
0.5 part of glycerol, 0.5 part of Phenoxyethanol, 1 part of aloe extract, 0.5 part of green-tea extract.
The preparation method of above-mentioned whitening and spot eliminating cream, includes the following steps:
(1) each raw material of component A is weighed, is heated with stirring to 80 DEG C, oily phase, heat preservation for standby use is made；
(2) hyaluronic acid is uniformly mixed using the glycerol in B component with xanthan gum, moisturizing thickener is made；By B component
In water when being heated to 60 DEG C, niacinamide and Radix Sophorae Flavescentis extractive liquid is added, continues to be heated to 80 DEG C, is mixed into moisturizing thickener, stirs
Uniformly, water phase is obtained；
(3) the oil phase is added to the aqueous phase, 2000r/min homogeneous 10min, and (25r/min) cooling is then stirred under vacuum；
(4) component C, 2000r/min homogeneous 3min, at creams shape are added when being cooled to 65 DEG C；
(5) continue to stir (25r/min) cooling under vacuum, be added when being cooled to 45 DEG C when stirring (25r/min) in advance
D component, component E, the F component sufficiently dissolved, uniformly mixed (D component, component E, F component dissolve in advance respectively, wherein D component
45 DEG C are heated to when dissolution)；
(6) G component is added when continuing to be cooled to 40 DEG C, crosses the discharging of 80 mesh filter clothes after mixing evenly, room temperature is aged after discharging
24h。
Embodiment 4
It choosing 70 volunteers and tries out whitening and spot eliminating cream obtained in embodiment 1-3, subject is women, and 17-52 weeks
Year, face skin have chloasma, sunburn, pigmentation isodispersity mixed stain, are randomly divided into 7 groups, every group of 10 people.
Everyone selects at 10 spot as test point to subject, uses German CK company dermal melanin and ferroheme test
Instrument MX 18 measures melanin value, is repeated 3 times and takes mean value, is denoted as initial value.Each group content in freckle cream is smeared daily morning and evening, is measured within every 7 days
Test point melanin value, is repeated 3 times and takes mean value, is denoted as n-th day measured value.
Wherein embodiment 1-3 whitening and spot eliminating cream (preparation is completed to try out in 7 days) is respectively as experimental group 1-3,1 beauty of embodiment
White (25-35 DEG C) of the preparatory room temperature of content in freckle cream is stored 3 months, as experimental group 4, commercially available arbutin content in freckle cream as a control group 1.
Control group 2: 4- butyl resorcinol, VC ethylether and Trenaxmine are replaced with into equivalent on that basis of example 1
Niacinamide, benzophenone-3 and ethylhexyl methoxy cinnamate replace with the shea butter of equivalent.Remaining ingredient and manufacture craft
With embodiment 1 (preparation is completed to try out in 7 days).
Control group 3: on the basis of embodiment 1, polyacrylate is directly added in oil whipping process mutually mixed with water
Cross-linked polymer -6, homogeneous 6min；D component, component E, F component, G group is added after being cooled to 40 DEG C in 30r/min stirring under vacuum
Point.Remaining step uses preceding preparatory storage 3 months with embodiment 1.
After 28 days, every subject's melanin value change rate, melanin value change rate=(initial value-the n-th day are counted
Measured value)/initial value × 100%, and each group average black element value change rate is calculated, experimental result is shown in Table 1.
Table 1
Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with other
The difference of embodiment, the same or similar parts in each embodiment may refer to each other.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (10)
1. a kind of whitening and spot eliminating cream, which is characterized in that based on parts by weight, including the following raw material:
Component A: 0.2-1 parts of benzophenone-3,1-3 parts of ethylhexyl methoxy cinnamate, 2-6 parts of emulsifier, 2-5 parts of moisturizing alcohol,
10-15 parts of grease；
B component: 20-40 parts of water, 1-5 parts of niacinamide, 8-15 parts of Radix Sophorae Flavescentis extractive liquid, 2.35-6.65 parts of moisturizing thickener；
Component C: 0.5-2 parts of viscosity modifier；
D component: 0.5-1.5 parts of 4- butyl resorcinol, 5-10 parts of solvent；
Component E: 0.5-1.5 parts of VC ethylether, 1-5 parts of water；
F component: 0.5-1 parts of Trenaxmine, 1-5 parts of water；
G component: 0.05-0.2 parts of menthyl lactate, silk 1-1.5 parts of hydrolysis, 0.05-0.15 parts of phytic acid, antibacterial agent 1.2-2.5
Part, 1-2 parts of plant desensitizer.
2. a kind of whitening and spot eliminating cream according to claim 1, which is characterized in that in the component A: moisturizing alcohol is the third two
One of alcohol, 1,3 butylene glycol, glycerol are a variety of；Grease is one of shea butter, SIMMONDSIA CHINENSIS SEED OIL or a variety of.
3. a kind of whitening and spot eliminating cream according to claim 1, which is characterized in that in the B component: moisturizing thickener includes
0.05-0.15 parts of hyaluronic acid, 2-6 parts and xanthan gum 0.3-0.5 parts of glycerol.
4. a kind of whitening and spot eliminating cream according to claim 1, which is characterized in that the component C is polyacrylate crosslinking
Polymer -6.
5. a kind of whitening and spot eliminating cream according to claim 1, which is characterized in that the solvent in the D component is 1,3- fourth
Glycol.
6. a kind of whitening and spot eliminating cream according to claim 1, which is characterized in that in the G component: antibacterial agent includes glycerol
0.5-1 parts of caprylate, 0.5-1 parts and Phenoxyethanol 0.2-0.5 parts of Sensiva SC50；Plant desensitizer includes aloe extraction
Object, Baical Skullcap root P.E, Gotu Kola P.E, any one or more in green-tea extract.
7. a kind of preparation method of any whitening and spot eliminating cream of claim 1-6, which comprises the steps of:
(1) each raw material of component A is weighed, is heated with stirring to 75-80 DEG C, oily phase is made, for use；
(2) when the water in B component being heated to 50-60 DEG C, niacinamide and Radix Sophorae Flavescentis extractive liquid is added, is heated to 75-80 DEG C, is mixed into
Moisturizing thickener, stirs evenly, and obtains water phase；
(3) the oil phase is added to the aqueous phase, stirs cooling under vacuum after mixing；
(4) component C is added when being cooled to 65 DEG C, is uniformly mixed, at creams shape；
(5) continue stirring cooling under vacuum, D component, component E, F component is added when being cooled to 45 DEG C, is uniformly mixed；
(6) G component is added when being cooled to 40 DEG C, after mixing evenly filtering and discharging.
8. a kind of preparation method of whitening and spot eliminating cream according to claim 7, which is characterized in that the moisturizing in step (2)
Thickener is pre-mixed uniformly；D component, component E, F component sufficiently dissolution in advance respectively in step (5), wherein D component dissolves
When be heated to 40-45 DEG C.
9. a kind of preparation method of whitening and spot eliminating cream according to claim 7, which is characterized in that the filtering in step (6)
To cross 80 mesh filter clothes.
10. a kind of preparation method of whitening and spot eliminating cream according to claim 7, which is characterized in that room temperature is aged after discharging
24h。
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