CN103040692B

CN103040692B - Composition for whitening skin

Info

Publication number: CN103040692B
Application number: CN201310030522.1A
Authority: CN
Inventors: 徐良; 毕富玲; 王婧; 曾鸣
Original assignee: BEIJING INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Current assignee: Beijing Yiqing Research Institute Co.,Ltd.
Priority date: 2012-11-15
Filing date: 2013-01-28
Publication date: 2014-04-02
Anticipated expiration: 2033-01-28
Also published as: CN103040692A

Abstract

The invention discloses a composition for whitening skin, which comprises whitening functional components including persimmon leaf extractive, ginkgo leaf extractive, lotus extractive, crocus sativus flower extractivea pomegranate fruit extractive, dogwood fruit extractive, licoflavone, nicotinamide and ascorbyl glucoside. According to the invention, the whitening functional components can act before generating melanin, in the process of generating melanin, and after generating melanin; the purpose of whitening skin is achieved in multiple aspects of inhibiting gene expression of related rate-limiting enzyme synthesized by melanin, inhibiting enzymatic activity of the related rate-limiting enzyme synthesized by melanin, eliminating oxygen free radicals, reducing generated melanin, limiting melanin to transfer towards horn cells and the like; therefore, the composition for whitening skin disclosed by the invention is safe and effective.

Description

A kind of compositions for skin-whitening

Technical field

The invention belongs to cosmetic field, relate to a kind of compositions for skin-whitening.

Background technology

The fair and clear target that always is that Nails is pursued of skin is beautiful symbol.In the color of skin and skin, melanic content is closely related, so the core that skin is carried out to whitening is to make melanic content in skin to be down to a lower level.

The synthetic main process of melanin is as follows: under the effect of tryrosinase, and first catalyzed DOPA and the DOPA quinone of being oxidized to of the tyrosine in human body, DOPA quinone and then become dopachrome.Dopachrome can generate melanin through two kinds of approach, and the first approach is that the spontaneous decarboxylation of dopachrome is polymerized to 5,6-dihydroxy indole, and this indole is oxidized to 5,6-dihydroxy indole quinone, and then forms melanin; The second approach is that dopachrome generates 5 under the dopachrome tautomerase effect of (claiming again TRP-2), 6-dihydroxy indole-2-carboxylic acid, this carboxylic acid generates 5 under the effect of (claiming again tyrosinase related protein-1) of dihydroxy indole carboxylic oxidase, 6-istain carboxylic acid, and then generate melanin.Melanin will be transferred to the horn cell of skin surface metabolism thereupon after generating from melanocyte.

Around melanin, synthetic and extension process is carried out whitening to skin, relates generally to three phases: before melanin is synthetic, in melanin building-up process, melanin synthetic after.Therefore, a cosmetics with outstanding whitening effect, should can play a role in above three different phases.

Before melanin is synthetic, should first consider to stop melanin to synthesize the gene expression of the rate-limiting enzymes such as required tryrosinase, dopachrome tautomerase, dihydroxy indole carboxylic oxidase, from source, control the output of the synthetic relevant rate-limiting enzyme of melanin, and then melanic synthetic quantity is reduced.

In melanin building-up process, mainly should consider to suppress the activity of above-mentioned three kinds of rate-limiting enzymes, the activity of tryrosinase especially, thus block melanic generation chain.In addition, having oxygen-derived free radicals is one of oxygen source of tyrosinase catalysis oxidation reaction, therefore removes that to have oxygen-derived free radicals be also the emphasis that need consider in this stage.

After melanin is synthetic, should consider that the oxidisability melanin that makes black is reduced into light reproducibility pigment, stops melanin by melanocyte, to be transferred to the horn cell of skin surface.

The whitening additive or the product that exist in the market, seldom can be comprehensively for above-mentioned three phases and related difference of each stage because usually realizing whitening.

Summary of the invention

The object of the present invention is to provide and a kind ofly can reduce from multi-angle, multipath the lightening compositions of dermal melanin content.

For achieving the above object, the invention provides a kind of compositions, its Raw forms percent meter by weight and comprises: Folium Kaki extract 1%-9%, Folium Ginkgo extract 1%-9%, Flos Nelumbinis extract 1%-9%, Stigma Croci flower extract 1%-9%, Punica granatum L. extract 1%-9%, cornel fruit extract 1%-9%, licoflavone 1%-9%, nicotiamide 4%-6%, ascorbic acid glucoside 2%-3%, potassium hydroxide is appropriate, and citric acid is appropriate, deionized water 4%-8%, imidazolidinyl urea 0.2%, methyl hydroxybenzoate 0.2%, propyl hydroxybenzoate 0.1%, all the other are propylene glycol.

Preparation method of composition is as follows:

1) ascorbic acid glucoside is dissolved in to deionized water, adds potassium hydroxide to regulate pH value to 6.5 ~ 6.8, standby;

2) by propylene glycol heating, to 70 ℃ of left and right, add methyl hydroxybenzoate, propyl hydroxybenzoate, stir;

3) treat that solution is down to 40 ℃ of left and right, add Folium Kaki extract, Folium Ginkgo extract, Flos Nelumbinis extract, Stigma Croci flower extract, cornel fruit extract, Punica granatum L. extract, licoflavone, nicotiamide, stir;

4) add imidazolidinyl urea, stir;

5) add potassium hydroxide or citric acid regulating solution pH value to 6.5 ~ 6.8;

6) add the ascorbic acid glucoside solution preparing, stir, be down to room temperature discharging.

The expression of the mRNA of Folium Ginkgo extract, Punica granatum L. extract energy restraint of tyrosinase, dopachrome tautomerase, dihydroxy indole carboxylic oxidase in compositions of the present invention, makes these three kinds of melanin synthesize the yield reducation of relevant rate-limiting enzyme.In addition, Folium Ginkgo extract also has the ability that good removing has oxygen-derived free radicals.

The effective activity of restraint of tyrosinase of Stigma Croci flower extract, cornel fruit extract in compositions of the present invention.

Licoflavone in compositions of the present invention, has good inhibitory action to the dopachrome tautomerase in melanin building-up process, dihydroxy indole carboxylic acid oxidative enzymatic activity.

In compositions of the present invention, Flos Nelumbinis extract, ascorbic acid glucoside have good non-oxidizability and reproducibility, can reduce the melanin having generated.

The transfer of nicotiamide energy check melanin from melanocyte to horn cell in compositions of the present invention.

The propagation of Folium Kaki extract energy check melanin cell in compositions of the present invention, thus melanic amount vector effectively reduced.In addition, Folium Kaki extract can be combined with tryrosinase, also can be combined with tyrosine enzyme-substrate complex, thereby effectively reduce the activity of tryrosinase.

To sum up, the present invention is a kind of compositions that comprises multiple white-skinned face function composition, can before, during and after melanin generates, all bring into play effect by three phases, and the over-deposit of check melanin, realizes skin-whitening effectively.

The specific embodiment:

Embodiment 1:

For a compositions for skin-whitening, by composition total weight percent, contain: Folium Kaki extract 9%, Folium Ginkgo extract 5%, Flos Nelumbinis extract 9%, Stigma Croci flower extract 5%, Punica granatum L. extract 9%, cornel fruit extract 9%, licoflavone 9%, nicotiamide 4%, ascorbic acid glucoside 2%, potassium hydroxide is appropriate, and citric acid is appropriate, deionized water 5%, imidazolidinyl urea 0.2%, methyl hydroxybenzoate 0.2%, propyl hydroxybenzoate 0.1%, all the other are propylene glycol.

Preparation technology's flow process is: ascorbic acid glucoside is dissolved in to deionized water, adds potassium hydroxide to regulate pH value to 6.5 ~ 6.8, and standby; By propylene glycol heating, during to 70 ℃ of left and right, add methyl hydroxybenzoate, propyl hydroxybenzoate, stir; When solution is down to 40 ℃ of left and right, add Folium Kaki extract, Folium Ginkgo extract, Flos Nelumbinis extract, Stigma Croci flower extract, cornel fruit extract, Punica granatum L. extract, licoflavone, nicotiamide, stir; Add imidazolidinyl urea, stir; Add potassium hydroxide or citric acid regulating solution pH value to 6.5 ~ 6.8; Add the ascorbic acid glucoside solution preparing, stir, be down to room temperature discharging.

Experiment showed, that compositions of the present invention has good white-skinned face function, and compatibility is good, can adds in cosmetics common formulations, as cream frost, emulsion, gel, water preparation.

Embodiment 2:

For a compositions for skin-whitening, by composition total weight percent, contain: Folium Kaki extract 7%, Folium Ginkgo extract 6%, Flos Nelumbinis extract 7%, Stigma Croci flower extract 6%, Punica granatum L. extract 8%, cornel fruit extract 8%, licoflavone 9%, nicotiamide 5%, ascorbic acid glucoside 2.5%, potassium hydroxide is appropriate, and citric acid is appropriate, deionized water 6.25%, imidazolidinyl urea 0.2%, methyl hydroxybenzoate 0.2%, propyl hydroxybenzoate 0.1%, all the other are propylene glycol.

Preparation technology's flow process is with embodiment 1.

Embodiment 3:

For a compositions for skin-whitening, by composition total weight percent, contain: Folium Kaki extract 9%, Folium Ginkgo extract 7%, Flos Nelumbinis extract 5%, Stigma Croci flower extract 7%, Punica granatum L. extract 7%, cornel fruit extract 7%, licoflavone 6%, nicotiamide 5%, ascorbic acid glucoside 2.5%, potassium hydroxide is appropriate, and citric acid is appropriate, deionized water 6.25%, imidazolidinyl urea 0.2%, methyl hydroxybenzoate 0.2%, propyl hydroxybenzoate 0.1%, all the other are propylene glycol.

Preparation technology's flow process is with embodiment 1.

Embodiment 4:

For a compositions for skin-whitening, by composition total weight percent, contain: Folium Kaki extract 7%, Folium Ginkgo extract 8%, Flos Nelumbinis extract 7%, Stigma Croci flower extract 8%, Punica granatum L. extract 6%, cornel fruit extract 6%, licoflavone 9%, nicotiamide 6%, ascorbic acid glucoside 3%, potassium hydroxide is appropriate, and citric acid is appropriate, deionized water 7.5%, imidazolidinyl urea 0.2%, methyl hydroxybenzoate 0.2%, propyl hydroxybenzoate 0.1%, all the other are propylene glycol.

Preparation technology's flow process is with embodiment 1.

Embodiment 5:

For a compositions for skin-whitening, by composition total weight percent, contain: Folium Kaki extract 9%, Folium Ginkgo extract 9%, Flos Nelumbinis extract 5%, Stigma Croci flower extract 9%, Punica granatum L. extract 5%, cornel fruit extract 5%, licoflavone 6%, nicotiamide 6%, ascorbic acid glucoside 3%, potassium hydroxide is appropriate, and citric acid is appropriate, deionized water 7.5%, imidazolidinyl urea 0.2%, methyl hydroxybenzoate 0.2%, propyl hydroxybenzoate 0.1%, all the other are propylene glycol.

Preparation technology's flow process is with embodiment 1.

The embodiment more than enumerating is to explanation of the present invention, does not represent protection scope of the present invention, and any improvement of the present invention being carried out without prejudice to connotation of the present invention all belongs to the protection domain that the present invention requires.

Claims

1. for a compositions for skin-whitening, it is characterized in that percent meter comprises by weight: white-skinned face function composition Folium Kaki extract 1%-9%, Folium Ginkgo extract 1%-9%, Flos Nelumbinis extract 1%-9%, Stigma Croci flower extract 1%-9%, Punica granatum L. extract 1%-9%, cornel fruit extract 1%-9%, licoflavone 1%-9%, nicotiamide 4%-6%, ascorbic acid glucoside 2%-3%; PH value regulator potassium hydroxide is appropriate, citric acid is appropriate; Deionized water 4-8%; Antiseptic imidazolidinyl urea 0.2%, methyl hydroxybenzoate 0.2%, propyl hydroxybenzoate 0.1%; All the other are propylene glycol.

2. the application of compositions according to claim 1 in skin-lightening cosmetic.

3. application according to claim 2, the dosage form that it is characterized in that described cosmetics is cream frost, emulsion, gel or water preparation.