CN114306118A - Whitening anti-aging skin care composition and application thereof - Google Patents
Whitening anti-aging skin care composition and application thereof Download PDFInfo
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- CN114306118A CN114306118A CN202111494784.4A CN202111494784A CN114306118A CN 114306118 A CN114306118 A CN 114306118A CN 202111494784 A CN202111494784 A CN 202111494784A CN 114306118 A CN114306118 A CN 114306118A
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Abstract
The invention discloses a whitening and anti-aging skin care composition and application thereof, belonging to the field of skin care products; the composition of the whitening anti-aging skin care product comprises the following components: glycerol, polydimethylsiloxane, propylene glycol, nicotinamide, carnosine, ergothioneine, tranexamic acid, arbutin, vitamin E acetate, vitamin C ethyl ether, D-pantothenic acid, pyridoxine dipalmitate, essence and water. The whitening, anti-aging and skin-care composition has the advantages of easily available raw materials, low cost, fine texture, uniform color and fresh smell, can play the roles of maintaining skin whitening, resisting ultraviolet radiation, slowing down skin aging and promoting skin regeneration, and has the advantages of wide applicability and easiness in manufacturing.
Description
Technical Field
The invention belongs to the field of skin care products, and particularly relates to a formula and a preparation method of a skin care product for whitening and resisting aging.
Background
Whitening and skin care are one of the important contents in the field of health, and skin care has become an important direction for medical health. Due to the damage of ultraviolet irradiation, the stimulation caused by air pollution, the influence of radiation of various electrical appliances such as computers, mobile phones and the like, more and more factors cause the skin to generate excessive free radicals or active oxygen, and further cause the skin problems such as dullness, color spots, wrinkles and the like. Whitening and anti-aging have become important contents for skin care. One of the factors determining the skin depth depends on the content and distribution of melanin in the skin, and is directly related to tyrosine, tyrosinase, free radicals and oxygen, and the oxygen free radicals can induce the skin cuticle to release alpha-melanocyte stimulating hormone, thereby promoting melanin synthesis. Chinese patent CN112778439A discloses a whitening skin care product and a preparation method thereof, wherein a kojic acid derivative of 2, 4, 6-trihydroxybenzoic acid-hyaluronic acid kojic acid ester-ester is added in the whitening skin care product, and the kojic acid derivative has excellent inoxidizability, excellent neuraminidase inhibition activity and good water retention, wrinkle resistance and repair functions, and is particularly suitable for the whitening skin care product. Chinese patent CN112773730A discloses an application of micro RNA in whitening skin care products, and particularly, miR-181a-5p and miR-199a can respectively inhibit melanin synthesis and promote melanin degradation, can make skin white and bright, and can maintain healthy, natural and bright skin.
Therefore, in order to meet the requirements of whitening and skin care, the development of a whitening and anti-aging skin care product with low price and obvious and safe effect is necessary.
Disclosure of Invention
The invention aims to provide a whitening and anti-aging skin care composition and application thereof, so as to solve the problems in the background technology.
The niacinamide has the function of influencing the transfer of melanocytes and keratinocytes, arbutin can inhibit the proliferation of melanin of cells, and a phenol group contained in the arbutin is an effective inhibitor of tyrosinase, has the antioxidation function, and can effectively inhibit the activity of tyrosinase and the formation of melanin, thereby achieving the whitening effect; however, the commercially available nicotinamide often contains a large amount of nicotinic acid components, which affects the use effect of nicotinamide. The tranexamic acid can inhibit the enzyme activity of protease, etc., and can inhibit melanin from enhancing inhibitory factor group, and block melanin generation pathway formed by ultraviolet irradiation, and vitamin C and its derivatives can prevent the oxidation process of melanin, remove oxygen free radical, and reduce melanin intermediate to inhibit the generation of melanin. Vitamin E released by vitamin E acetate through metabolism has the effects of improving dermal metabolism, promoting cell regeneration and reducing wrinkles; pyridoxine dipalmitate has effects of preventing and treating pachylosis and acne.
In order to achieve the purpose, the invention provides the following technical scheme:
1. the whitening and anti-aging skin care composition is characterized by comprising the following components in percentage by weight: 6-12% of glycerin, 6-12% of polydimethylsiloxane, 2-6% of propylene glycol, 2-4% of nicotinamide, 0.5-3% of carnosine, 1-2% of ergothioneine, 0.5-2% of tranexamic acid, 0.5-1% of arbutin, 0.2-0.5% of vitamin E acetate, 0.2-0.5% of vitamin C ethyl ether, 0.2-0.5% of D-pantothenic acid, 0.1-0.5% of pyridoxine dipalmitate, 0.1-0.2% of essence and the balance of water.
Preferably, the whitening and anti-aging skin care composition consists of the following components in percentage by weight: 8-10% of glycerol, 8-10% of polydimethylsiloxane, 4-5% of propylene glycol, 2.5-3.5% of purified nicotinamide, 1-2% of carnosine, 1.2-1.8% of ergothioneine, 1-1.5% of tranexamic acid, 0.6-0.8% of arbutin, 0.3-0.4% of vitamin E acetate, 0.3-0.4% of vitamin C ethyl ether, 0.3-0.4% of D-pantothenic acid, 0.2-0.4% of pyridoxine dipalmitate, 0.12-0.18% of essence and the balance of water.
Preferably, the whitening and anti-aging skin care composition consists of the following components in percentage by weight: glycerol 8%, polydimethylsiloxane 8%, propylene glycol 4%, nicotinamide 3.5%, carnosine 2%, ergothioneine 1.2%, tranexamic acid 1%, arbutin 0.6%, vitamin E acetate 0.3%, vitamin C ethyl ether 0.3%, D-pantothenic acid 0.3%, pyridoxine dipalmitate 0.2%, perfume 0.12%, and balance water.
Preferably, the whitening and anti-aging skin care composition consists of the following components in percentage by weight: glycerol 6%, polydimethylsiloxane 6%, propylene glycol 4.5%, nicotinamide 3%, carnosine 1.5%, ergothioneine 1.5%, tranexamic acid 2%, arbutin 0.7%, phenethyl resorcinol 0.5%, vitamin E acetate 0.35%, vitamin C ethyl ether 0.35%, D-pantothenic acid 0.35%, pyridoxine dipalmitate 0.25%, perfume 0.15%, and balance water.
The nicotinamide needs to be purified before use, and the purification method comprises the following steps:
1) putting the nicotinamide crude product into water with the temperature of 25-40 ℃, and adjusting the pH value to 6.5-8.5 to obtain a crude product solution;
2) controlling the temperature of the crude product solution below 30-50 ℃, removing impurities through electrodialysis, stopping electrodialysis when the conductance of the solution reaches 0.15-0.25ms/cm to obtain a primary pure nicotinamide solution, adding 717 anion exchange resin into the primary pure nicotinamide solution, stirring for 0.5-2h, filtering to remove the anion exchange resin, adding activated carbon into the filtered filtrate for decolorization, filtering to remove the activated carbon after decolorization, concentrating the obtained feed liquid in vacuum to 50-55%, slowly cooling for crystallization, preserving the temperature for 1.5-3h when the temperature is reduced to 0-5 ℃, and drying to obtain a purified nicotinamide finished product.
The mass fraction of the crude product solution is 8-20%.
The 717 mass fraction of the anion exchange resin is 0.5-2%.
The mass fraction of the active carbon is 0.5-1%, the temperature is controlled to 60-70 ℃, and the decoloring time is 0.5-1 h.
The whitening and anti-aging skin care composition is applied to skin care milk, cream or ointment and the like.
2. The application of the whitening and anti-aging skin care composition in skin care milk, cream or ointment and the like comprises the following steps:
1) water phase: mixing the glycerol, the nicotinamide, the carnosine, the ergothioneine, the tranexamic acid, the D-pantothenic acid and 4 times of water according to the proportion, and heating to 80-90 ℃ to completely dissolve the glycerol, the nicotinamide, the carnosine, the ergothioneine, the tranexamic acid and the D-pantothenic acid;
2) organic phase: uniformly mixing polydimethylsiloxane, arbutin, vitamin E acetate, vitamin C ethyl ether, pyridoxine dipalmitate and essence according to the proportion, heating to 80-90 ℃, and preserving heat;
3) and (3) adding the water phase part in the step (1) into the organic phase in the step (2) according to the proportion, supplementing the residual water according to the total amount of the water in the formula, fully and uniformly stirring, cooling to 50-30 ℃, and filling to obtain the whitening and anti-aging skin care product.
Compared with the prior art, the invention has the following beneficial effects:
1. the whitening skin care formula has the advantages of easily available raw materials, low cost, fine texture, uniform color and fresh smell, can play the roles of maintaining skin whitening, resisting ultraviolet radiation, slowing down skin aging and promoting skin regeneration, and has the advantages of wide applicability and high acceptance.
2. The nicotinamide purification process adopts three modes of electrodialysis, anion exchange resin adsorption and active carbon to jointly remove impurities, the purity of the obtained product is as high as 99.8%, and the operation is simple.
Detailed Description
The present invention is further illustrated by the following specific examples, but it should be understood by those skilled in the art that the specific examples of the present invention are not intended to limit the present invention in any way, and any equivalents based on the present invention are within the scope of the present invention.
Example 1:
purification of nicotinamide: putting 14.25kg of nicotinamide crude product with the content of 98.0% into water at 40 ℃ to prepare a solution with the content of 18.5%, adjusting the pH to 8.5 by using ammonia water, controlling the temperature to be below 40 ℃, removing impurities by adopting electrodialysis, stopping the electrodialysis when the conductance reaches 0.2ms/cm, adding 717 anion exchange resin with the weight of 1% of the nicotinamide into the nicotinamide solution, stirring for 0.5-1h, filtering, adding activated carbon with the weight of 0.5% of the weight of the nicotinamide for decolorization, controlling the temperature to be 60-70 ℃ for 0.5-1h, filtering to remove the activated carbon, vacuum concentrating to 50% at the temperature of 70 ℃, slowly cooling for crystallization, keeping the temperature for 2h when the temperature is reduced to 15 ℃, performing solid-liquid separation to obtain nicotinamide wet powder, drying to obtain a finished product with the purity of 99.8%, wherein unknown impurities are less than or equal to 0.02%, and the content of nicotinic acid is 17 ppm.
Example 2:
preparing a skin care product: the preparation of each material was carried out under the conditions of 12% of glycerin, 12% of polydimethylsiloxane, 6% of propylene glycol, 4% of nicotinamide, 3% of carnosine, 2% of ergothioneine, 2% of tranexamic acid, 1% of arbutin, 0.5% of vitamin E acetate, 0.5% of vitamin C ethyl ether, 0.5% of D-pantothenic acid, 0.5% of pyridoxine dipalmitate, 0.2% of essence, and the balance of water.
In a clean area, the skin care product with the formula is prepared by mixing glycerol, nicotinamide, carnosine, ergothioneine, tranexamic acid, D-pantothenic acid and a small amount of water in a water phase part, and rapidly heating to 85 ℃ to completely dissolve the components for later use. Mixing organic phase part of polydimethylsiloxane, arbutin, vitamin E acetate, vitamin c ethyl ether, pyridoxine dipalmitate and essence, rapidly heating to 85 deg.C, and keeping the temperature; and then adding the phenethyl resorcinol, the propylene glycol and the water phase part into the organic phase, further stirring and dissolving the components mutually, cooling to 45-36 ℃, sampling and detecting the proportion of each component after uniformly mixing, and directly filling to obtain the whitening and anti-aging skin care product after reaching the internal control standard.
Example 3:
preparing a skin care product: raw material preparation is carried out under the conditions of 6% of glycerin, 6% of polydimethylsiloxane, 6% of propylene glycol, 2% of nicotinamide, 0.5% of carnosine, 1% of ergothioneine, 0.5% of tranexamic acid, 0.5% of arbutin, 0.2% of vitamin E acetate, 0.2% of vitamin c ethyl ether, 0.2% of D-pantothenic acid, 0.1% of pyridoxine dipalmitate, 0.1% of essence and the balance of water.
In a clean area, the raw materials prepared in the formula are selected from glycerol, nicotinamide, carnosine, ergothioneine, tranexamic acid, D-pantothenic acid and a small amount of water in a water phase part to be mixed, and the temperature is quickly raised to 85 ℃ to completely dissolve the raw materials for later use. Mixing organic phase parts of arbutin, vitamin E acetate, vitamin c ethyl ether, pyridoxine dipalmitate and essence, rapidly heating to 85 deg.C, and keeping the temperature; and then adding phenethyl resorcinol, propylene glycol and the water phase part into the organic phase, further stirring and dissolving the components mutually, cooling to 45-36 ℃, sampling and detecting the proportion of each component, and directly filling after uniformly mixing to obtain the whitening and anti-aging skin care product.
3. Skin care effect test of the whitening skin care cosmetic of example 2:
the face of 3 volunteers (2 women, 1 man) was washed before sleeping every morning and evening, and then applied with cosmetics in a slightly visible amount.
The change in skin color was measured using a commercially available colorimeter 1d before application of the cosmetics and 30 th, 60 th and 90 th after application. The test was performed 3 times in succession and the average was taken (see table 1).
TABLE 1 comparison of the color differences Δ E over time using the cosmetics of example 1
| Test sample | 1d | 30d | 60d | 90d |
| Volunteer 1 | 3.01 | 3.12 | 3.14 | 3.56 |
| Volunteer 2 | 4.72 | 4.85 | 5.21 | 6.77 |
| Volunteer 3 | 3.18 | 3.26 | 3.66 | 4.12 |
The Δ E value indicates the position change of the color in the color space, the larger the numerical value, the more obvious the color change, and the change of the skin chromaticity can be comprehensively reflected, and as can be seen from table 1, the Δ E of the volunteer increases with the change of the time, which indicates that the cosmetic can remarkably improve the skin brightness.
In the process of using the whitening and skin-care cosmetic provided in example 2 and 1 month after stopping using the whitening and skin-care cosmetic, the skin of 3 volunteers was kept in a good state, and no adverse reactions such as irritation and allergy and obvious rebound occurred.
Claims (10)
1. The whitening and anti-aging skin care composition is characterized by comprising the following components in percentage by weight: 6-12% of glycerin, 6-12% of polydimethylsiloxane, 2-6% of propylene glycol, 2-4% of nicotinamide, 0.5-3% of carnosine, 1-2% of ergothioneine, 0.5-2% of tranexamic acid, 0.5-1% of arbutin, 0.2-0.5% of vitamin E acetate, 0.2-0.5% of vitamin C ethyl ether, 0.2-0.5% of D-pantothenic acid, 0.1-0.5% of pyridoxine dipalmitate, 0.1-0.2% of essence and the balance of water.
2. The whitening and anti-aging skin care composition according to claim 1, which is characterized by comprising the following components in percentage by weight: 8-10% of glycerol, 8-10% of polydimethylsiloxane, 4-5% of propylene glycol, 2.5-3.5% of purified nicotinamide, 1-2% of carnosine, 1.2-1.8% of ergothioneine, 1-1.5% of tranexamic acid, 0.6-0.8% of arbutin, 0.3-0.4% of vitamin E acetate, 0.3-0.4% of vitamin C ethyl ether, 0.3-0.4% of D-pantothenic acid, 0.2-0.4% of pyridoxine dipalmitate, 0.12-0.18% of essence and the balance of water.
3. The whitening and anti-aging skin care composition according to claim 2, which is characterized by comprising the following components in percentage by weight: glycerol 8%, polydimethylsiloxane 8%, propylene glycol 4%, nicotinamide 3.5%, carnosine 2%, ergothioneine 1.2%, tranexamic acid 1%, arbutin 0.6%, vitamin E acetate 0.3%, vitamin C ethyl ether 0.3%, D-pantothenic acid 0.3%, pyridoxine dipalmitate 0.2%, perfume 0.12%, and balance water.
4. The whitening and anti-aging skin care composition according to claim 1, which is characterized by comprising the following components in percentage by weight: glycerol 6%, polydimethylsiloxane 6%, propylene glycol 4.5%, nicotinamide 3%, carnosine 1.5%, ergothioneine 1.5%, tranexamic acid 2%, arbutin 0.7%, phenethyl resorcinol 0.5%, vitamin E acetate 0.35%, vitamin C ethyl ether 0.35%, D-pantothenic acid 0.35%, pyridoxine dipalmitate 0.25%, perfume 0.15%, and balance water.
5. The whitening and anti-aging skin care composition according to claim 1 or 2, wherein the niacinamide needs to be purified before use by the following method:
1) putting the nicotinamide crude product into water with the temperature of 25-40 ℃, and adjusting the pH value to 6.5-8.5 to obtain a crude product solution;
2) controlling the temperature of the crude product solution below 30-50 ℃, removing impurities through electrodialysis, stopping electrodialysis when the conductance of the solution reaches 0.15-0.25ms/cm to obtain a primary pure nicotinamide solution, adding 717 anion exchange resin into the primary pure nicotinamide solution, stirring for 0.5-2h, filtering to remove the anion exchange resin, adding activated carbon into the filtered filtrate for decolorization, filtering to remove the activated carbon after decolorization, concentrating the obtained feed liquid in vacuum to 50-55%, slowly cooling for crystallization, preserving the temperature for 1.5-3h when the temperature is reduced to 0-5 ℃, and drying to obtain a purified nicotinamide finished product.
6. The whitening and anti-aging skin care composition as claimed in claim 5, wherein the mass fraction of the crude product solution is 8-20%.
7. The whitening and anti-aging skin care composition according to claim 5, wherein the 717 anion exchange resin accounts for 0.5 to 2 percent of the mass fraction.
8. The whitening and anti-aging skin care composition according to claim 5, wherein the mass fraction of the activated carbon is 0.5-1%, the temperature is controlled to be 60-70 ℃, and the decoloring time is 0.5-1 h.
9. The whitening and anti-aging skin care composition as defined in claim 5, wherein the whitening and anti-aging skin care composition is applied to skin care milk, cream or ointment.
10. Use according to claim 9, characterized in that it comprises the following steps:
1) water phase: mixing the glycerol, the nicotinamide, the carnosine, the ergothioneine, the tranexamic acid, the D-pantothenic acid and 4 times of water according to the proportion, and heating to 80-90 ℃ to completely dissolve the glycerol, the nicotinamide, the carnosine, the ergothioneine, the tranexamic acid and the D-pantothenic acid;
2) organic phase: uniformly mixing polydimethylsiloxane, arbutin, vitamin E acetate, vitamin C ethyl ether, pyridoxine dipalmitate and essence according to the proportion, heating to 80-90 ℃, and preserving heat;
3) and (3) adding the water phase part in the step (1) into the organic phase in the step (2) according to the proportion, supplementing the residual water according to the total amount of the water in the formula, fully and uniformly stirring, cooling to 50-30 ℃, and filling to obtain the whitening and anti-aging skin care product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116158988A (en) * | 2023-03-21 | 2023-05-26 | 江苏仅三生物科技有限公司 | Skin care composition with whitening and anti-aging effects and application thereof |
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| CN102219734A (en) * | 2011-05-10 | 2011-10-19 | 浙江爱迪亚营养科技开发有限公司 | Preparation method for nicotinamide |
| CN109549863A (en) * | 2018-12-24 | 2019-04-02 | 深圳市琉璃光生物科技有限公司 | A kind of lightening compositions and preparation method thereof |
| CN112618400A (en) * | 2021-01-29 | 2021-04-09 | 山东华熙海御生物医药有限公司 | Composition for improving skin color and whitening cosmetic |
| CN112932996A (en) * | 2021-02-03 | 2021-06-11 | 深圳市护家科技有限公司 | Whitening composition and essence thereof |
| CN113321614A (en) * | 2021-08-02 | 2021-08-31 | 北京四环制药有限公司 | Recycling method of nicotinamide crystallization mother liquor |
-
2021
- 2021-12-08 CN CN202111494784.4A patent/CN114306118A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102219734A (en) * | 2011-05-10 | 2011-10-19 | 浙江爱迪亚营养科技开发有限公司 | Preparation method for nicotinamide |
| CN109549863A (en) * | 2018-12-24 | 2019-04-02 | 深圳市琉璃光生物科技有限公司 | A kind of lightening compositions and preparation method thereof |
| CN112618400A (en) * | 2021-01-29 | 2021-04-09 | 山东华熙海御生物医药有限公司 | Composition for improving skin color and whitening cosmetic |
| CN112932996A (en) * | 2021-02-03 | 2021-06-11 | 深圳市护家科技有限公司 | Whitening composition and essence thereof |
| CN113321614A (en) * | 2021-08-02 | 2021-08-31 | 北京四环制药有限公司 | Recycling method of nicotinamide crystallization mother liquor |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116158988A (en) * | 2023-03-21 | 2023-05-26 | 江苏仅三生物科技有限公司 | Skin care composition with whitening and anti-aging effects and application thereof |
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