CN110559206A

CN110559206A - Multidirectional anti-wrinkle polypeptide essence and preparation method thereof

Info

Publication number: CN110559206A
Application number: CN201911040757.2A
Authority: CN
Inventors: 张立萍; 方一泓; 张丽娜; 吴长机
Original assignee: Changchun Shemai Jiatian Cosmetics Co Ltd
Current assignee: Changchun Shemai Jiatian Cosmetics Co Ltd
Priority date: 2019-10-30
Filing date: 2019-10-30
Publication date: 2019-12-13

Abstract

The invention discloses a multi-azimuth anti-wrinkle polypeptide essence and a preparation method thereof, and the multi-azimuth anti-wrinkle polypeptide essence is prepared by compounding a plurality of polypeptides and assisting a plurality of plant extracts, so that expression lines are prevented, collagen generation is promoted, dermal tissues are repaired, and the like, and multi-azimuth anti-wrinkle is carried out; meanwhile, the essence is prepared in a cold mixing mode, so that the inactivation of active substances caused by improper reaction temperature is avoided.

Description

Multidirectional anti-wrinkle polypeptide essence and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to a multi-aspect anti-wrinkle polypeptide essence and a preparation method thereof.

background

Skin aging is a continuous and gradual physiological process which directly affects the appearance and function of skin, and wrinkles are a sign of the appearance of skin aging and are called as 'annual rings of life'. With the improvement of the life quality of people, the anti-aging, wrinkle removal and rejuvenation become topics concerned by consumers.

the human body is a living body with rich emotion, the expression is used as an image body language, the psychological state of the human body is not represented at all times, the facial muscles are inevitably dragged when the expression is displayed, and the skin is temporarily wrinkled and folded along with the contraction of the facial muscles. The long-term continuous action is easy to cause dynamic expression lines. Meanwhile, with the age, the collagen and elastin fibers in the dermal tissue are damaged due to the decline of the metabolic capability of the skin and the influence of exogenous factors, so that the integrity of the dermal tissue structure is damaged, an irreversible static line is formed, and the dynamic line is very easy to convert into the static line. Both the dynamic warp and the static grain show the aging traces of years out of the world, which is not accepted by beauty-loving women.

The product with wrinkle resistance is declared to be full of line on the market, however, many products adopt high molecular polymer analogues, such as choline ethylene glycol polyphosphate acrylate/acrylic acid (ester), cross-linked polymer-like sodium-2, specially treated sodium hyaluronate and the like, and only have the instant effect of covering wrinkles and forming a false effect; or the efficacy raw materials are used for resisting wrinkles in a single way, and the effect of resisting wrinkles cannot be good, so that a multi-direction anti-wrinkle product from inside to outside is particularly important.

Disclosure of Invention

In order to solve the problems, the invention provides a multi-azimuth anti-wrinkle polypeptide essence and a preparation method thereof, and the primary purpose of the invention is to prevent expression wrinkles, promote collagen generation, repair dermal tissues and the like from multi-azimuth anti-wrinkle by compounding a plurality of polypeptides and assisting a plurality of plant extracts; meanwhile, the essence is prepared in a cold mixing mode, so that the inactivation of active substances caused by improper reaction temperature is avoided.

The invention is realized by the following technical scheme:

A multi-directional anti-wrinkle polypeptide essence is composed of the following raw materials in parts by weight:

the polypeptide mixed solution comprises acetyl octapeptide-3, acetyl hexapeptide-8, palmitoyl pentapeptide-4 and dipeptide diaminobutyrylbenzylamide diacetate.

Furthermore, the mass ratio of the acetyl octapeptide-3 to the acetyl hexapeptide-8 to the palmitoyl pentapeptide-4 to the dipeptide diaminobutyrylbenzylamide diacetate is 3-8:3-10:3-10: 1-4.

Further, 0.3 to 0.8 weight portion of preservative is also included; the preservative is a mixed extract compounded by artemisia capillaris flower extract and clove flower extract.

Further, the weight ratio of the artemisia capillaris flower extract to the clove flower extract is 1: 0.5-0.8.

Further, the moisturizing and soothing agent comprises 3-5 parts of erythritol, 1-4 parts of dihydroavenyl anthranilic acid and 1.2-4.5 parts of a mixed extract compounded by trehalose, a radix ophiopogonis extract and a prickly pear stem extract.

Further, the weight ratio of the trehalose to the radix ophiopogonis extract to the prickly pear stem extract is 0.5-1.5: 0.4-1.5: 0.3-1.5.

Further, the acrylic acid/C12-22 alkanol methacrylate copolymer also comprises 0.1-1 weight part of acrylic acid (ester)/acrylic acid (ester).

further, the multi-aspect anti-wrinkle polypeptide essence consists of the following raw materials in parts by weight: 63.45 parts of aloe extract, 4 parts of 1, 2-pentanediol, 36 parts of acetyl octapeptide, 85 parts of acetyl hexapeptide, 44 parts of palmitoyl pentapeptide, 2 parts of dipeptide diaminobutyryl benzylamide diacetate, 3 parts of erythritol, 0.2 part of carnitine HCl, 0.5 part of dendrobium stem extract, 0.1 part of sophora flavescens ait root extract, 0.3 part of lycium barbarum fruit extract, 0.2 part of echinacea purpurea extract, 1.5 parts of 1, 3-propanediol, 0.8 part of saccharide isomer, 0.5 part of trehalose, 0.7 part of ophiopogon root extract, 1 part of opuntia ficus-indica stem extract, 3 parts of dihydroavenoylaminobenzoic acid, 0.3 part of acrylic acid (ester)/C12-22 alkanol methacrylate copolymer, 0.3 part of arginine, 0.4 part of artemisia capillaris flower extract and 0.2 part of clove flower extract.

The invention also comprises a preparation method of the multi-aspect anti-wrinkle polypeptide essence, which comprises the following steps:

(1) mixing Aloe extract, stem extract of herba Dendrobii, radix Sophorae Flavescentis extract, fructus Lycii extract of Ningxia and Echinacea purpurea extract at room temperature to obtain component A;

(2) Mixing the polypeptide mixed solution, the moisturizing soothing agent and the saccharide isomerate at room temperature to obtain a component B;

(3) And uniformly stirring and mixing the component A and the component B, adding 1, 3-propylene glycol, 1, 2-pentanediol, sarcosine HCl, a preservative, an acrylic acid (ester)/C12-22 alkanol methacrylate copolymer and arginine, and uniformly mixing to obtain the anti-wrinkle polypeptide essence.

the invention has the beneficial effects that:

1. The compound skin care composition is compounded with a plurality of polypeptides and a plurality of plant extracts, so that the compound skin care composition can effectively prevent and inhibit dynamic expression lines in a synergistic manner, promote the synthesis of collagen, elastin and glycosaminoglycan per se, remodel healthy and compact skin structure, repair deep moisture and water of static lines formed by damaged dermal tissue structures caused by internal and external factors, promote aquaporin, promote skin microcirculation and repair skin barriers. Meanwhile, the aloe vera leaf juice replaces production water, more active substances are added, the effects of relieving and resisting inflammation are achieved, the clove and the artemisia capillaris are ground, a natural plant anticorrosion environment is built, damage of the preservative to the skin is reduced, and the aloe vera leaf juice is suitable for sensitive skin.

2. The compound preparation is compounded with a plurality of polypeptides and a plurality of plant extracts, so that the compound preparation is synergistic, dynamic expression lines are effectively prevented and inhibited, the synthesis of collagen, elastin and glycosaminoglycan per se is promoted, healthy and compact skin structures are remodeled, static lines formed by damaged dermal tissue structures caused by internal and external factors are repaired, the generation of wrinkles is prevented from the source by acetyl hexapeptide-8, acetyl octapeptide-3 and dipeptide diaminobutyryl benzylamide diacetate, the release of neurotransmitters can be effectively blocked by the acetyl hexapeptide-8 and the acetyl octapeptide-3, the muscle contraction is reduced, and the generation of dynamic lines is prevented and inhibited; the dipeptide diaminobutyrylbenzylamide diacetate inhibits the combination of neurotransmitters and receptors, thereby effectively relaxing muscles and preventing and inhibiting dynamic wrinkle formation; the palmitoyl pentapeptide-4 and various plant extracts have synergistic effect to repair damaged skin, so that wrinkles are improved; palmitoyl pentapeptide-4 can promote the synthesis of collagen, elastin and glycosaminoglycan in types I, III and IV, rebuild a dermal tissue structure to be full, effectively improve static wrinkles, inhibit the conversion of dynamic lines to static lines, promote the synthesis of collagen, elastin and glycosaminoglycan in types I, III and IV, and strengthen the dermal tissue structure, and the addition of extracts such as dendrobium stem extract, sophora flavescens root extract, lycium barbarum fruit extract, echinacea purpurea extract and the like promotes the expression of aquaporin AQP3 in cells, replenishes fluid to generate body fluid, deeply replenishes water, smoothes fine lines and scurf caused by drying, and further improves wrinkles; in addition, the plant extract can promote the absorption of the polypeptide mixture, thereby improving the function of each functional substance, improving wrinkles in multiple directions, durably nourishing and moistening the skin, creating a good moisturizing effect, and meanwhile, the plant extract can also clear free radicals, relieve and moisten the skin and enable the skin to be moisturized and permeable.

3. The radix ophiopogonis extract and the twisted cactus stem extract can strengthen the adhesion and fixation between the upper cuticle layer and a protective film (trehalose forms the protective film), promote the recombination and formation of a skin barrier and promote the recombination and formation of the skin barrier, the radix ophiopogonis extract and the twisted cactus stem extract are active ingredients containing polyfructose, and the tubers contain mucus which can gather water, so that the water replenishing and moisturizing function is strong; the trehalose is slowly released from the protective film, so that the skin can be sustainably and mildly moistened, and the dendrobium stem extract can improve the moisture content of the skin and improve the expression of aquaporin AQP 3; the addition of erythritol in the humectant can reduce the sticky feeling caused by the radix ophiopogonis extract, the prickly pear stem extract and trehalose; the formed double protective film can lock various trace elements and amino acids rich in the Ningxia wolfberry fruit, so as to prevent nutrient loss; the trehalose, the radix ophiopogonis extract, the twisted cactus stem extract and the dihydrooat acyl anthranilic acid are compounded, so that the skin is effectively calmed, inflammation is eliminated, itching is relieved, redness and swelling are relieved, and the effects of skin passivation and skin immunity and tolerance improvement are achieved.

4. The artemisia capillaris flower extract and the clove flower extract are compounded, and the vacuum pump bottle is adopted for physical corrosion prevention, so that the heating risk of the traditional preservative or the polyol popular in the market instead of the traditional preservative is completely eliminated.

Drawings

FIG. 1 is a bar graph of fibroblast viability versus product;

FIG. 2 is a visual effect diagram of the nasolabial sulcus of volunteer 1;

FIG. 3 is a visual effect diagram of the nasolabial sulcus of volunteer 2;

FIG. 4 is a visual effect diagram of the nasolabial sulcus of the volunteer 3;

FIG. 5 is a diagram of the visual effect of the volunteer 4 around the eyes;

Fig. 6 is a diagram of the visual effect of 5 volunteers around the eyes.

Detailed Description

In order to better understand the present invention, the following examples are further described, which are only used to explain the present invention and do not limit the present invention.

The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art, and the raw materials used are commercially available products.

Trehalose, radix Ophiopogonis extract, radix Opuntiae Dillenii stem extract, and radix Sophorae Flavescentis extract are from vast Sen Biotech limited of Beijing Oriental; erythritol and sarcosine HCl are from france stadama; linlan Runlu is from vast forest Biotech, Inc., Beijing Oriental; erythritol and carnosine HCl are derived from Smadama acetyl octapeptide-3, acetyl hexapeptide-8, palmitoyl pentapeptide-4, dipeptide diaminobutyrylbenzylamide diacetate from Dongguan Hua Industrial Co., Ltd

Example 1

A preparation method of multi-azimuth anti-wrinkle polypeptide essence comprises the following steps:

A multi-directional anti-wrinkle polypeptide essence is composed of the following raw materials in parts by weight

63.45 parts of aloe extract, 4 parts of 1, 2-pentanediol, 36 parts of acetyl octapeptide, 85 parts of acetyl hexapeptide, 44 parts of palmitoyl pentapeptide, 2 parts of dipeptide diaminobutyryl benzylamide diacetate, 3 parts of erythritol, 0.2 part of carnitine HCl, 0.5 part of dendrobium stem extract, 0.1 part of sophora flavescens ait root extract, 0.3 part of lycium barbarum fruit extract, 0.2 part of echinacea purpurea extract, 1.5 parts of 1, 3-propanediol, 0.8 part of saccharide isomer, 0.5 part of trehalose, 0.7 part of ophiopogon root extract, 1 part of opuntia ficus-indica stem extract, 3 parts of dihydroavenoylaminobenzoic acid, 0.3 part of acrylic acid (ester)/C12-22 alkanol methacrylate copolymer, 0.3 part of arginine, 0.4 part of artemisia capillaris flower extract and 0.2 part of clove flower extract.

Best mode for carrying out the invention

68 parts of aloe extract, 3 parts of 1, 2-pentanediol, 34 parts of acetyl octapeptide, 87 parts of acetyl hexapeptide, 45 parts of palmitoyl pentapeptide, 2 parts of dipeptide diaminobutyryl benzylamide diacetate, 3 parts of erythritol, 0.2 part of carnitine HCl, 0.5 part of dendrobium stem extract, 0.1 part of sophora flavescens ait root extract, 0.3 part of lycium barbarum fruit extract, 0.2 part of echinacea purpurea extract, 1.5 parts of 1, 3-propanediol, 0.8 part of saccharide isomer, 0.5 part of trehalose, 0.7 part of ophiopogon root extract, 1 part of opuntia ficus-indica stem extract, 3 parts of dihydroavenoylaminobenzoic acid, 0.3 part of acrylic acid (ester)/C12-22 alkanol methacrylate copolymer, 0.3 part of arginine, 0.3 part of artemisia capillaris flower extract and 0.24 part of clove flower extract.

Best mode for carrying out the invention

65 parts of aloe extract, 3 parts of 1, 2-pentanediol, 38 parts of acetyl octapeptide, 87 parts of acetyl hexapeptide, 46 parts of palmitoyl pentapeptide, 2 parts of dipeptide diaminobutyrylbenzylamide diacetate, 5 parts of erythritol, 0.5 part of carnitine HCl, 1 part of dendrobium stem extract, 0.08 part of sophora flavescens ait root extract, 0.5 part of fructus lycii ningxia, 0.3 part of echinacea purpurea extract, 2 parts of 1, 3-propanediol, 0.8 part of saccharide isomer, 3 parts of glyceryl caprylate, 2.5 parts of trehalose, 0.7 part of radix ophiopogonis root extract, 1.5 parts of opuntia stem extract, 3 parts of dihydroavenoylaminobenzoic acid, 0.3 part of acrylic acid (ester)/C12-22 alkanol methacrylate copolymer, 0.3 part of arginine, 0.3 part of artemisia capillaris flower extract and 0.15 part of clove extract.

testing

first, the anti-wrinkle essence prepared in example 1 (hereinafter referred to as wrinkle-smoothing anti-wrinkle polypeptide essence 1, numbered 190701a) and example 2 (hereinafter referred to as wrinkle-smoothing anti-wrinkle polypeptide essence 2, numbered 190701B) were tested by entrusting the innovation center of green functional daily use chemical products, and the test results are as follows

[ PROJECT/PARAMETERS ]

1. water content of horny layer of skin

2. skin percutaneous water loss

3. Elasticity of skin

4. Facial imaging-wrinkle area ratio analysis

[ TEST OBJECT ] the safety and efficacy evaluation is carried out according to the ingredient characteristics and efficacy declaration characteristics of each product, so that objective data is obtained to better support the market popularization of the products.

[ test samples ] Table 1

Sample numbering	Sample name	Test number
			/	Wrinkle-removing polypeptide essence 1	190701A
/	wrinkle-removing polypeptide essence 2	190701B

[ test sites ] Table 2

[ test time points ] Table 3

[ sample distribution ] Table 4

Subject number	left hand sample	Right sample	subject number	left hand sample	Right sample
						1907001A01*	190701A	190701B	1907001A05	190701A	190701B
1907001A02	190701B	190701A	1907001A06*	190701B	190701A
						1907001A03	190701A	190701B	1907001A07	190701A	190701B
1907001A04	190701B	190701A	1907001A08	190701B	190701A

*: indicating an intermediate exit from the test for private reasons

1. Test conditions

Subjects were 8, with subjects TQH (1907001A01), HLH (1907001A06) withdrawn from the test midway for private reasons, so the final sample size was 6.

Wherein: the average age is 45 years (37-56 years); [ female ]: [ male ] ═ 5: 1; [ dry ]: [ oily ] ═ 4: 2.

2. Instrument information

skin moisture test probe, Corneometer CM825, skin moisture loss test probe manufactured by COAURAGE + KHAZAKA (CK) of Germany, Tewameter TM300, skin elasticity tester manufactured by COAURAGE + KHAZAKA (CK) of Germany, Cutomer dual MPA580, face image analyzer manufactured by COAURAGE + KHAZAKA (CK) of Germany, VISIA-CR, manufactured by Canfield Scientific of America

3. Results

on each detection index, the wrinkle-smoothing and wrinkle-resisting polypeptide essence 1 and the wrinkle-smoothing and wrinkle-resisting polypeptide essence 2 have no difference in performance.

4. Design of experiments

Test protocol

Samples 190701a, 190701B were randomly distributed on the left and right faces of volunteers using methods: the composition is administered by volunteers in the morning and evening by 1 time per day, about 0.4g each time (i.e. 3 times by pressing the pump head), and is continuously administered for 28 days. The stratum corneum moisture content test, the skin elasticity test, the skin transdermal moisture loss test, and the facial imaging were performed before the product was used (noted as "initial value") "" second week after use (noted as "second week"), fourth week after use (noted as "fourth week"), assisted by questionnaire investigations (questionnaires include skin feel and feeling of use).

4.1. Volunteer selection

according to the declaration of helsinki, the selection of volunteers follows the medical and ethical criteria of human testing, all of which must be performed from the volunteers

[ Admission criteria ]

Volunteers meeting all of the following conditions will be enrolled:

Volunteers 25-65 years old;

there are eye-tail lines, statute lines, or head-up lines.

5. The result of the detection

5.1. water content of horny layer of skin

The moisture content of the stratum corneum of the skin was measured before use, 2 and 4 weeks after use, and the results were obtained

TABLE 5 summary of results of stratum corneum moisture content before and after application of samples

(-meaning no significant difference; + meaning significant difference)

As can be seen from table 5, compared with the initial values, the moisture content of the stratum corneum of the skin in the areas where the wrinkle-soothing and wrinkle-reducing polypeptide essences 1 and 2 were used was significantly increased at week four (P < 0.05). Comparison between samples: within four weeks, there was no significant difference in the change in moisture content of the stratum corneum of the skin in the areas where the wrinkle-soothing and anti-wrinkle polypeptide essences 1 and 2 were used (P > 0.05). Compared with the same sample, the water content of the horny layer of the skin is increased along with the prolonging of the using time, which shows that the essence has the effect of long-acting water replenishing. The data of different samples show almost unchanged effect, which indicates that the essence is stable well. (sample one is a sample which is subjected to a high-temperature test at 45 ℃ for 7 days, namely a normal-temperature normal sample.)

5.2. Skin percutaneous water loss

The skin was tested for percutaneous water loss before and 2, 4 weeks after application, and the results were obtained

TABLE 6 summary of results of skin transdermal water loss before and after use of samples

(-meaning no significant difference; + meaning significant difference)

as is clear from table 6, the amount of skin moisture loss through skin was significantly reduced in both areas using the wrinkle-soothing and wrinkle-reducing polypeptide essences 1 and 2 at week four (P <0.05) as compared with the initial values. Comparison between samples: within four weeks, there was no significant difference in the change in the amount of skin transdermal water loss using the wrinkle-soothing anti-wrinkle polypeptide essences 1 and 2 (P > 0.05). Compared with the same sample, the loss of moisture in the skin is continuously reduced along with the prolonging of the using time, which shows that the essence has the function of repairing the skin barrier and reduces the evaporation of the moisture in the skin. The data of different samples show almost unchanged effect, which indicates that the essence is stable well. (sample one is a sample which is subjected to a high-temperature test at 45 ℃ for 7 days, namely a normal-temperature normal sample.)

5.3. Elasticity of skin

the skin elasticity was tested before, 2 and 4 weeks after application, and the R2 value was taken as an indicator of skin elasticity: TABLE 7 summary of results of skin elasticity (R2 values) before and after use of the samples

(-meaning no significant difference; + meaning significant difference)

As can be seen from table 7, the skin elasticity (R2 value) was significantly increased in the area of the tail of the eye (P <0.05) by using the wrinkle-soothing and wrinkle-reducing polypeptide essences 1 and 2 at week four, as compared with the initial values. Comparison between samples: within four weeks, there was no significant difference in changes in skin elasticity (R2 value) in the caudal region of the eyes using wrinkle-soothing anti-wrinkle polypeptide essences 1,2 (P > 0.05).

5.4. Facial imaging-wrinkle area ratio analysis

The photographs of the face before and after 2 and 4 weeks of use were analyzed by an IPP image analysis system, and the percentage of wrinkled face was taken as an index:

TABLE 8 summary of results using sample ratio of front and back wrinkle face

(-meaning no significant difference; + meaning significant difference)

As can be seen from table 8, the wrinkle area ratio of the region using the wrinkle-soothing and wrinkle-reducing polypeptide essence 1 was significantly reduced (P <0.05) from the second week compared to the initial value; from the fourth week, the wrinkle area ratio of the region using the wrinkle-removing and anti-wrinkle polypeptide essence 2 is remarkably reduced (P < 0.05). Comparison between samples: within four weeks, there was no significant difference in the change in wrinkle area ratio of the areas using wrinkle-soothing anti-wrinkle polypeptide essences 1 and 2 (P > 0.05).

From the figures 2-4, which are the visual effect graphs of the nose, lip and the sulcus of the nose of the volunteer, and the figures 5-6, which are the visual effect graphs of the eye circumference of the volunteer, it can be seen that the facial lines at the nasal wing and the eye corner of the volunteer are obviously reduced after the volunteer uses the essence for 4 weeks.

Second, determination of fibroblast viability of essence [ fibroblast viability determination experiment, essence used without preservative ]

The testing steps are as follows: measurement by flow cytometry using propidium iodide staining

placebo:

91.9 parts of aloe vera extract, 1.5 parts of 1, 3-propylene glycol, 0.8 part of saccharide isomer, 0.5 part of trehalose, 0.7 part of radix ophiopogonis extract, 1 part of twisted cactus stem extract, 3 parts of dihydroavenyl anthranilic acid, 0.3 part of acrylic acid (ester)/C12-22 alkanol methacrylate copolymer and 0.3 part of arginine.

Firstly, culturing the cells of the same batch with different essences and placebo respectively, then staining the cells with propidium iodide, and detecting the activity of the cell package and characteristic parameters of various aspects of biophysics and biochemistry by a flow cytometer.

As shown in FIG. 1, it can be seen from FIG. 1 that the present invention can greatly enhance the activity of fibroblasts, thereby enhancing the synthesis of collagen.

Third, full inspection

The Shenzhen Limited company of the delegated spectral Ni test group carries out detection, and the detection result is shown in the following table 9;

As can be seen from table 9 above, the essence of the present application meets the standards of skin care products.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims

1. The multidirectional anti-wrinkle polypeptide essence is characterized by comprising the following raw materials in parts by weight:

10-32 parts of polypeptide mixed liquor;

50-75 parts of aloe extract;

5.2-13.5 parts of a moisturizing soothing agent;

0.5-1 part of dendrobium stem extract;

0.05-0.1 part of sophora flavescens root extract;

0.2-0.5 part of Ningxia wolfberry fruit extract;

0.1-0.4 parts of echinacea purpurea extract;

1-3 parts of 1, 3-propylene glycol;

0.5-1.5 parts of saccharide isomer;

1-5 parts of 1, 2-pentanediol;

0.2-0.7 part of creatinine HCl;

0.1-1 part of arginine;

2. The multi-aspect anti-wrinkle polypeptide essence according to claim 1, wherein: the mass ratio of the acetyl octapeptide-3, the acetyl hexapeptide-8, the palmitoyl pentapeptide-4 and the dipeptide diaminobutyrylbenzylamide diacetate is 3-8:3-10:3-10: 1-4.

3. The multi-azimuth anti-wrinkle polypeptide essence according to claim 1 or 2, wherein: also comprises 0.3 to 0.8 weight portion of preservative; the preservative is a mixed extract compounded by artemisia capillaris flower extract and clove flower extract.

4. the multi-aspect anti-wrinkle polypeptide essence according to claim 3, wherein: the weight ratio of the artemisia capillaris flower extract to the clove flower extract is 1: 0.5-0.8.

5. The multi-aspect anti-wrinkle polypeptide essence of claim 4, wherein: the moisturizing and soothing agent comprises 3-5 parts of erythritol, 1-4 parts of dihydroavenyl anthranilic acid and 1.2-4.5 parts of a mixed extract compounded by trehalose, an ophiopogon root extract and a prickly pear stem extract.

6. The multi-aspect anti-wrinkle polypeptide essence of claim 5, wherein: the weight ratio of the trehalose to the radix ophiopogonis extract to the prickly pear stem extract is 0.5-1.5: 0.4-1.5: 0.3-1.5.

7. the multi-aspect anti-wrinkle polypeptide essence of claim 6, wherein: also comprises 0.1 to 1 weight part of acrylic acid (ester)/C12 to 22 alkanol methacrylate copolymer.

8. The multi-azimuth anti-wrinkle polypeptide essence according to claim 7, which is prepared from the following raw materials in parts by weight: 63.45 parts of aloe extract, 4 parts of 1, 2-pentanediol, 36 parts of acetyl octapeptide, 85 parts of acetyl hexapeptide, 44 parts of palmitoyl pentapeptide, 2 parts of dipeptide diaminobutyryl benzylamide diacetate, 3 parts of erythritol, 0.2 part of carnitine HCl, 0.5 part of dendrobium stem extract, 0.1 part of sophora flavescens ait root extract, 0.3 part of lycium barbarum fruit extract, 0.2 part of echinacea purpurea extract, 1.5 parts of 1, 3-propanediol, 0.8 part of saccharide isomer, 0.5 part of trehalose, 0.7 part of ophiopogon root extract, 1 part of opuntia ficus-indica stem extract, 3 parts of dihydroavenoylaminobenzoic acid, 0.3 part of acrylic acid (ester)/C12-22 alkanol methacrylate copolymer, 0.3 part of arginine, 0.4 part of artemisia capillaris flower extract and 0.2 part of clove flower extract.

9. a preparation method of multi-azimuth anti-wrinkle polypeptide essence is characterized by comprising the following steps:

mixing Aloe extract, stem extract of herba Dendrobii, radix Sophorae Flavescentis extract, fructus Lycii extract of Ningxia and Echinacea purpurea extract at room temperature to obtain component A;

Mixing the polypeptide mixed solution, the moisturizing soothing agent and the saccharide isomerate at room temperature to obtain a component B;

And uniformly stirring and mixing the component A and the component B, adding 1, 3-propylene glycol, 1, 2-pentanediol, sarcosine HCl, a preservative, an acrylic acid (ester)/C12-22 alkanol methacrylate copolymer and arginine, and uniformly mixing to obtain the anti-wrinkle polypeptide essence.