CN111067852A - Essence containing polypeptide and preparation method thereof - Google Patents
Essence containing polypeptide and preparation method thereof Download PDFInfo
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- CN111067852A CN111067852A CN202010058017.8A CN202010058017A CN111067852A CN 111067852 A CN111067852 A CN 111067852A CN 202010058017 A CN202010058017 A CN 202010058017A CN 111067852 A CN111067852 A CN 111067852A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/445—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof aromatic, i.e. the carboxylic acid directly linked to the aromatic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses an essence containing polypeptide and a preparation method thereof, wherein the preparation method comprises the following steps: 1) weighing Aloe barbadensis leaf extract raw materials, adding into a pot, adding thickener while stirring, and stirring to dissolve completely to obtain component A; 2) mixing humectant, anti-allergy agent, and other effective components at room temperature under stirring to obtain component B; 3) stirring and mixing the polypeptide components at room temperature to prepare a component C; 4) sequentially adding the component B and the component C into the component A, and uniformly stirring; 5) weighing antioxidant, plant antiseptic and aromatic in sequence, adding into a pan, and stirring well; 6) detecting pH =5.00-7.00, filtering and discharging with 200 mesh filter cloth. The product has polypeptide as core, small molecular weight, easy absorption, and can permeate into dermis. Different polypeptide types play different roles, meet the requirements of different functions of skin, and can achieve the effects of wrinkle smoothing, wrinkle resisting, lifting and tightening, skin whitening, skin brightening, yellow and ruddy removing, or soothing and repairing.
Description
Technical Field
The invention is applied to the field of cosmetics, and particularly relates to an essence containing polypeptide and a preparation method thereof.
Background
Along with the improvement of the life quality of people and the pursuit of people for beauty, cosmetics are more and more in variety. At present, the essence is an effective wrinkle-smoothing and wrinkle-resisting product for the beauty field.
The skin is a natural barrier of the human body against external environmental insults, and has a certain protective effect against external stimuli, which is benefited by the protective effect of the stratum corneum of the skin. However, the nutrient components of the cosmetics are kept on the surface of the skin, the nutrient substances can enter the dermis only by permeating the cell membrane of the horny layer, the essence is a nursing step with the smallest molecular particles and the strongest permeability and the highest nutrient components in all skin care products, the existing essence mostly takes chemical components and plant components as main components, although the molecular weight is small, only a small amount of essence reaches the dermis, and the effect is not obvious enough for the skin structure.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides the essence containing the polypeptide and the preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the essence containing the polypeptide comprises the following components in parts by weight:
further, the humectant is prepared from the following components in parts by weight:
2-5 parts of a mixture compounded by erythritol and sarcosine HCl;
1-3 parts of pentanediol;
water, glycerin, stem extract of Dendrobium nobile, leaf extract of Aloe barbadensis Miller, root extract of Sophora flavescens ait, fruit extract of Lycium barbarum and Echinacea purpurea extract
3-8 parts.
Further, the mixture compounded by the water, the glycerin, the stem extract of the dendrobium nobile, the leaf extract of the aloe barbadensis, the root extract of the sophora flavescens ait, the fruit extract of the lycium barbarum and the echinacea purpurea extract comprises the following components in percentage by weight: 60-80% of water, 15-25% of glycerol, 2-6% of stem extract of dendrobium stem, 1-3% of aloe barbadensis leaf extract, 1-3% of root extract of sophora flavescens ait, 0.5-2% of wolfberry fruit extract of Ningxia and 0.5-1% of echinacea purpurea extract.
Further, the anti-allergic agent is prepared from the following components in parts by weight:
2-5 parts of a mixture formed by compounding water, glycerol, trehalose, an ophiopogon root extract, a twisted cactus stem extract and a sophora flavescens root extract;
0.5-1 part of chlorphenamine maleate.
Further, the water, the glycerol, the trehalose, the radix ophiopogonis extract, the prickly pear stem extract and the sophora flavescens root extract are compounded into a mixture, and the mixture comprises the following components in percentage by weight: 50-58% of water, 25-30% of glycerol, 6-8% of trehalose, 3-6% of an ophiopogon root extract, 3-6% of a twisted cactus stem extract and 3-6% of a sophora flavescens root extract.
Further, the chlorpheniramine maleate comprises the following components in percentage by weight of 10: 10: 1 butanediol, 1, 2-pentanediol and dihydrooat acyl anthranilic acid.
Further, the plant preservative is prepared from the following components in parts by weight:
0.5-2 parts of a mixture compounded by artemisia capillaris flower extract and clove flower extract.
Further, the weight ratio of the artemisia capillaris flower extract to the clove flower extract in the mixture compounded by the artemisia capillaris flower extract and the clove flower extract is 2: 1.
further, the polypeptide is prepared from the following components in parts by weight:
a preparation method of essence containing polypeptide comprises the following steps:
1) weighing Aloe barbadensis leaf extract raw materials, adding into a pot, adding thickener while stirring, and stirring to dissolve completely to obtain component A;
2) mixing humectant, anti-allergy agent, and other effective components at room temperature under stirring to obtain component B;
3) stirring and mixing the polypeptide components at room temperature to prepare a component C;
4) sequentially adding the component B and the component C into the component A, and uniformly stirring;
5) weighing antioxidant, plant antiseptic and aromatic in sequence, adding into a pan, and stirring well;
6) detecting pH value to 5.00-7.00, filtering with 200 mesh filter cloth and discharging.
The invention adopts the technical scheme, takes the polypeptide as a core, has small molecular weight, is easy to absorb, and can permeate into the dermis. Different polypeptide types play different roles, and the requirements of different functions of skin are met; the compound plant moisturizing and nourishing essence is used for synergistically compounding various plants, and moisturizing and reviving the skin; the pure aloe vera leaf extract is used for replacing the traditional production water, so that the skin is conditioned and pacified more effectively, and more nutritional ingredients are dissolved into the skin; fine and rich texture, mild skin-friendly property, easy absorption, and full content of polypeptide and plant essence.
Detailed Description
The essence containing the polypeptide comprises the following components in parts by weight:
further, the humectant is prepared from the following components in parts by weight:
2-5 parts of a mixture compounded by erythritol and sarcosine HCl;
1-3 parts of pentanediol;
water, glycerin, stem extract of Dendrobium nobile, leaf extract of Aloe barbadensis Miller, root extract of Sophora flavescens ait, fruit extract of Lycium barbarum and Echinacea purpurea extract
3-8 parts.
Further, the mixture compounded by the water, the glycerin, the stem extract of the dendrobium nobile, the leaf extract of the aloe barbadensis, the root extract of the sophora flavescens ait, the fruit extract of the lycium barbarum and the echinacea purpurea extract comprises the following components in percentage by weight: 60-80% of water, 15-25% of glycerol, 2-6% of stem extract of dendrobium stem, 1-3% of aloe barbadensis leaf extract, 1-3% of root extract of sophora flavescens ait, 0.5-2% of wolfberry fruit extract of Ningxia and 0.5-1% of echinacea purpurea extract.
Further, the anti-allergic agent is prepared from the following components in parts by weight:
2-5 parts of a mixture formed by compounding water, glycerol, trehalose, an ophiopogon root extract, a twisted cactus stem extract and a sophora flavescens root extract;
0.5-1 part of chlorphenamine maleate.
Further, the water, the glycerol, the trehalose, the radix ophiopogonis extract, the prickly pear stem extract and the sophora flavescens root extract are compounded into a mixture, and the mixture comprises the following components in percentage by weight: 50-58% of water, 25-30% of glycerol, 6-8% of trehalose, 3-6% of an ophiopogon root extract, 3-6% of a twisted cactus stem extract and 3-6% of a sophora flavescens root extract.
Further, the chlorpheniramine maleate comprises the following components in percentage by weight of 10: 10: 1 butanediol, 1, 2-pentanediol and dihydrooat acyl anthranilic acid.
Further, the plant preservative is prepared from the following components in parts by weight:
0.5-2 parts of a mixture compounded by artemisia capillaris flower extract and clove flower extract.
Further, the weight ratio of the artemisia capillaris flower extract to the clove flower extract in the mixture compounded by the artemisia capillaris flower extract and the clove flower extract is 2: 1.
further, the polypeptide is prepared from the following components in parts by weight:
snake venom-like tripeptide (dipeptide diaminobutyrylbenzylamide diacetate) (2000-3000ppm)
3-8 parts.
The polypeptide can function relatively easily by crossing the stratum corneum space into the dermis.
Carnosine (carnosine), a dipeptide of β -alanine and L-histidine (β -Ala-L-His), is widely present in various organ tissues of the body and in muscle tissues at millimolar concentrations, is a natural non-enzymatic free radical scavenger and antioxidant, and achieves anti-aging effects through three aspects of (1) anti-oxidation-scavenging of free radicals, inhibition of oxidative stress reactions, (2) anti-glycation-inhibition of non-enzymatic glycation reactions, inhibition of glycation end products, and (3) protection from damage by sunlight (uv and ir), active oxygen Radical (ROS) quenchers and metal ion chelators, which can inhibit peroxidation in the skin, reduce oxidative damage to the skin, inhibit cross-linking and solidification of macromolecules in the dermis layer, which lead to wrinkle formation and loss of elasticity, and quench glycosylation end products (AGE), while promoting collagen synthesis and protecting skin cells from uv-irradiated DNA damage, preventing damage by ir.
Palmitoyl pentapeptide-4, a collagen reduction in the dermis of the skin, is considered to be a major cause of wrinkles formed by aging of the human body, and thus if the skin can be promoted to synthesize more collagen, it will be effective in reversing aging to reduce wrinkles. The peptide segment of palmitoyl pentapeptide-4 is a collagen fragment, which is the most abundant protein constituting the skin, and can promote the synthesis of macromolecular substances such as collagen I, III and IV, elastin and glycosaminoglycan, repair and reconstruct extracellular matrix and epidermal-dermal junction (DEJ) by acting on dermal fibroblasts, thereby solving the problem of wrinkles from the deep layer of the skin and improving the appearance of the skin.
Tripeptide-1 copper, a copper complex of glycyl-L-histidyl-L-lysine (GHK) peptide naturally present in human body GHK amino acid sequence is present in α 2(I) chain of type I collagen, GHK decomposed from collagen is released to the injury site when injury activates proteolytic enzyme, promoting wound healing, the content of GHK decreases with age, and the anti-aging and repairing abilities of skin gradually decrease, tripeptide-1 copper has the effect of promoting wound healing and tissue regeneration (skin, hair follicle, stomach and intestinal lining and bone tissue), can promote the production of collagen, glycosaminoglycan and decorin in skin, promote keratinocyte proliferation, increase epidermal thickness, tighten loose skin, improve skin elasticity, transparency and firmness, and at the same time, matrix metalloproteinase and its inhibitors can be regulated, preventing degradation of dermal layer matrix.
Oat peptide is a compound derived from oat, based on a unique advanced production process, and by utilizing modern biotechnology-enzyme engineering, protein in oat bran is dissociated into small molecular peptide, the peptide is very similar to Epidermal Growth Factor (EGF), is easy to be absorbed by skin, can accelerate cell proliferation, promote skin metabolism, activate skin, reduce skin roughness, increase skin elasticity, prevent skin lesion and make skin glowing and beautiful. Meanwhile, the skin moisturizing cream has excellent moisturizing effect, fine wrinkle repairing effect, capability of improving the skin resistance to external stimulation, skin protection enhancement, aging delaying effect and the like.
Oligopeptide-1, a small molecular weight synthetic tripeptide composed of glycine-histidine-lysine, is a signal peptide, and can stimulate the synthesis of extracellular matrix of dermis layer, promote tissue repair and reconstruction, reinforce dermis layer, improve skin firmness and reduce skin wrinkles when applied to dermis layer. Oligopeptide-1 is an endogenous collagen tripeptide, is present in interstitial fluid such as plasma, and decreases with age.
The generation of wrinkles is closely related to SNARE, wherein SNARE is a ternary structure formed by combining three proteins of VAMP, Syntaxin and SNAP-25, after a SNARE compound with a stable structure is formed, vesicles can be effectively combined with a membrane to release neurotransmitter (acetylcholine), and the acetylcholine is combined with a muscle cell receptor to generate action potential and cause muscle contraction to generate wrinkles.
Acetyl hexapeptide-8, an active polypeptide component, has a structure similar to SNAP-25. The molecular weight is smaller, and the absorption to the cortex Davidii is easier.
Acetyl octapeptide-3, an active, safe botulinum toxin-like peptide, is composed of 8 natural amino acids, an extended analog of acetyl hexapeptide-8. Two peptides longer than hexapeptide, the competitive power is stronger. The action mechanism is consistent, and the SNAP-25 competes to inhibit the formation of SNARE complex and block synaptic vesicles from releasing neurotransmitters, so that the muscle contraction is weakened, and the formation of wrinkles is prevented.
The snake venom tripeptide is a synthetic tripeptide with a small molecular weight, is a polypeptide with a post-synaptic strategy, can be used as an antagonist of a muscle nicotinic acetylcholine membrane receptor, can reversibly reduce muscle contraction, is suitable for local care for smoothing expression lines, inhibits nerve impulses transmitted to muscles despite release of acetylcholine in the process, reduces the formation of action potentials, and accordingly enables the facial muscles to keep relaxed to achieve the purpose of quickly removing wrinkles.
A preparation method of essence containing polypeptide comprises the following steps:
1) weighing Aloe barbadensis Miller leaf extract raw materials, adding thickener (acrylic acid (acrylate)/C12-22 alkanol methacrylate copolymer) under stirring, and stirring to dissolve completely to obtain component A;
2) mixing humectant, anti-allergy agent, and other effective components at room temperature under stirring to obtain component B;
3) stirring and mixing the polypeptide components at room temperature to prepare a component C;
4) sequentially adding the component B and the component C into the component A, and uniformly stirring;
5) weighing antioxidant, plant antiseptic and aromatic in sequence, adding into a pan, and stirring well;
6) detecting pH (100%) as 5.00-7.00, filtering with 200 mesh filter cloth and discharging.
The whole preparation process is kept without heating, the activity of the functional components is kept to the maximum extent, meanwhile, the whole process is stirred at a low speed, the stirring speed is controlled to be 10-20r/min, and more bubbles are avoided.
Example 1
The essence containing the polypeptide comprises the following components in parts by weight:
further, the humectant is prepared from the following components in parts by weight:
5 parts of a mixture compounded by erythritol and creatinine HCl;
3 parts of pentanediol;
8 parts of a mixture prepared by compounding water, glycerol, dendrobium stem extract, aloe barbadensis leaf extract, sophora flavescens root extract, lycium barbarum fruit extract and echinacea purpurea extract.
Further, the mixture compounded by the water, the glycerin, the stem extract of the dendrobium nobile, the leaf extract of the aloe barbadensis, the root extract of the sophora flavescens ait, the fruit extract of the lycium barbarum and the echinacea purpurea extract comprises the following components in percentage by weight: 60-80% of water, 15-25% of glycerol, 2-6% of stem extract of dendrobium stem, 1-3% of aloe barbadensis leaf extract, 1-3% of root extract of sophora flavescens ait, 0.5-2% of wolfberry fruit extract of Ningxia and 0.5-1% of echinacea purpurea extract.
Further, the anti-allergic agent is prepared from the following components in parts by weight:
5 parts of a mixture compounded by water, glycerol, trehalose, an ophiopogon root extract, a twisted cactus stem extract and a sophora flavescens root extract;
1 part of chlorphenamine maleate.
Further, the water, the glycerol, the trehalose, the radix ophiopogonis extract, the prickly pear stem extract and the sophora flavescens root extract are compounded into a mixture, and the mixture comprises the following components in percentage by weight: 50-58% of water, 25-30% of glycerol, 6-8% of trehalose, 3-6% of an ophiopogon root extract, 3-6% of a twisted cactus stem extract and 3-6% of a sophora flavescens root extract.
Further, the chlorpheniramine maleate comprises the following components in percentage by weight of 10: 10: 1 butanediol, 1, 2-pentanediol and dihydrooat acyl anthranilic acid.
Further, the plant preservative is prepared from the following components in parts by weight:
and 2 parts of a mixture compounded by the artemisia capillaris flower extract and the clove flower extract.
Further, the weight ratio of the artemisia capillaris flower extract to the clove flower extract in the mixture compounded by the artemisia capillaris flower extract and the clove flower extract is 2: 1.
further, the polypeptide is prepared from the following components in parts by weight:
a preparation method of essence containing polypeptide comprises the following steps:
1) weighing Aloe barbadensis leaf extract raw materials, adding into a pot, adding thickener while stirring, and stirring to dissolve completely to obtain component A;
2) mixing humectant, anti-allergy agent, and other effective components at room temperature under stirring to obtain component B;
3) stirring and mixing the polypeptide components at room temperature to prepare a component C;
4) sequentially adding the component B and the component C into the component A, and uniformly stirring;
5) weighing antioxidant, plant antiseptic and aromatic in sequence, adding into a pan, and stirring well;
6) the pH value is detected to be 6, and the mixture is filtered and discharged by a 200-mesh filter cloth.
Example 2
The essence containing the polypeptide comprises the following components in parts by weight:
further, the humectant is prepared from the following components in parts by weight:
2 parts of a mixture compounded by erythritol and creatinine HCl;
1 part of pentanediol;
water, glycerin, stem extract of Dendrobium nobile, leaf extract of Aloe barbadensis Miller, root extract of Sophora flavescens ait, fruit extract of Lycium barbarum and Echinacea purpurea extract
And 3 parts.
Further, the mixture compounded by the water, the glycerin, the stem extract of the dendrobium nobile, the leaf extract of the aloe barbadensis, the root extract of the sophora flavescens ait, the fruit extract of the lycium barbarum and the echinacea purpurea extract comprises the following components in percentage by weight: 60-80% of water, 15-25% of glycerol, 2-6% of stem extract of dendrobium stem, 1-3% of aloe barbadensis leaf extract, 1-3% of root extract of sophora flavescens ait, 0.5-2% of wolfberry fruit extract of Ningxia and 0.5-1% of echinacea purpurea extract.
Further, the anti-allergic agent is prepared from the following components in parts by weight:
2 parts of a mixture compounded by water, glycerol, trehalose, an ophiopogon root extract, a twisted cactus stem extract and a sophora flavescens root extract;
0.5 part of chlorphenamine maleate.
Further, the water, the glycerol, the trehalose, the radix ophiopogonis extract, the prickly pear stem extract and the sophora flavescens root extract are compounded into a mixture, and the mixture comprises the following components in percentage by weight: 50-58% of water, 25-30% of glycerol, 6-8% of trehalose, 3-6% of an ophiopogon root extract, 3-6% of a twisted cactus stem extract and 3-6% of a sophora flavescens root extract.
Further, the chlorpheniramine maleate comprises the following components in percentage by weight of 10: 10: 1 butanediol, 1, 2-pentanediol and dihydrooat acyl anthranilic acid.
Further, the plant preservative is prepared from the following components in parts by weight:
0.5 part of a mixture compounded by artemisia capillaris flower extract and clove flower extract.
Further, the weight ratio of the artemisia capillaris flower extract to the clove flower extract in the mixture compounded by the artemisia capillaris flower extract and the clove flower extract is 2: 1.
further, the polypeptide is prepared from the following components in parts by weight:
a preparation method of essence containing polypeptide comprises the following steps:
1) weighing Aloe barbadensis leaf extract raw materials, adding into a pot, adding thickener while stirring, and stirring to dissolve completely to obtain component A;
2) mixing humectant, anti-allergy agent, and other effective components at room temperature under stirring to obtain component B;
3) stirring and mixing the polypeptide components at room temperature to prepare a component C;
4) sequentially adding the component B and the component C into the component A, and uniformly stirring;
5) weighing antioxidant, plant antiseptic and aromatic in sequence, adding into a pan, and stirring well;
6) the pH value is detected to be 6, and the mixture is filtered and discharged by a 200-mesh filter cloth.
Example 3
The essence containing the polypeptide comprises the following components in parts by weight:
further, the humectant is prepared from the following components in parts by weight:
3 parts of a mixture compounded by erythritol and creatinine HCl;
2 parts of pentanediol;
6 parts of a mixture compounded by water, glycerin, dendrobium stem extract, aloe barbadensis leaf extract, sophora flavescens root extract, lycium barbarum fruit extract and echinacea purpurea extract.
Further, the mixture compounded by the water, the glycerin, the stem extract of the dendrobium nobile, the leaf extract of the aloe barbadensis, the root extract of the sophora flavescens ait, the fruit extract of the lycium barbarum and the echinacea purpurea extract comprises the following components in percentage by weight: 60-80% of water, 15-25% of glycerol, 2-6% of stem extract of dendrobium stem, 1-3% of aloe barbadensis leaf extract, 1-3% of root extract of sophora flavescens ait, 0.5-2% of wolfberry fruit extract of Ningxia and 0.5-1% of echinacea purpurea extract.
Further, the anti-allergic agent is prepared from the following components in parts by weight:
4 parts of a mixture formed by compounding water, glycerol, trehalose, an ophiopogon root extract, a twisted cactus stem extract and a sophora flavescens root extract;
0.7 part of chlorphenamine maleate.
Further, the water, the glycerol, the trehalose, the radix ophiopogonis extract, the prickly pear stem extract and the sophora flavescens root extract are compounded into a mixture, and the mixture comprises the following components in percentage by weight: 50-58% of water, 25-30% of glycerol, 6-8% of trehalose, 3-6% of an ophiopogon root extract, 3-6% of a twisted cactus stem extract and 3-6% of a sophora flavescens root extract.
Further, the chlorpheniramine maleate comprises the following components in percentage by weight of 10: 10: 1 butanediol, 1, 2-pentanediol and dihydrooat acyl anthranilic acid.
Further, the plant preservative is prepared from the following components in parts by weight:
1.5 parts of a mixture compounded by artemisia capillaris flower extract and clove flower extract.
Further, the weight ratio of the artemisia capillaris flower extract to the clove flower extract in the mixture compounded by the artemisia capillaris flower extract and the clove flower extract is 2: 1.
further, the polypeptide is prepared from the following components in parts by weight:
a preparation method of essence containing polypeptide comprises the following steps:
1) weighing Aloe barbadensis leaf extract raw materials, adding into a pot, adding thickener while stirring, and stirring to dissolve completely to obtain component A;
2) mixing humectant, anti-allergy agent, and other effective components at room temperature under stirring to obtain component B;
3) stirring and mixing the polypeptide components at room temperature to prepare a component C;
4) sequentially adding the component B and the component C into the component A, and uniformly stirring;
5) weighing antioxidant, plant antiseptic and aromatic in sequence, adding into a pan, and stirring well;
6) the pH value is detected to be 6, and the mixture is filtered and discharged by a 200-mesh filter cloth.
Application example
60 volunteers (35-55 years old) were used in the periocular region on a side-by-side basis, twice a day. The test was performed before use, 2 hours after use, and 4 weeks after use. Skin elasticity was tested and pictures were taken with a VISIA facial tester. After 2 hours of use: the skin elasticity is instantly improved and lasts for 2 hours, the eye tail tightness degree is obviously improved, and the skin elasticity R2 value is obviously improved. After 4 weeks of use: the eye tail tightness is obviously improved, the skin elasticity R2 value is obviously improved, and the area percentage of the fishtail lines is reduced by 15.5%.
Claims (10)
1. The essence containing the polypeptide is characterized in that: the paint comprises the following components in parts by weight:
2. the essence containing polypeptide according to claim 1, wherein: the humectant is prepared from the following components in parts by weight:
2-5 parts of a mixture compounded by erythritol and sarcosine HCl;
1-3 parts of pentanediol;
3-8 parts of a mixture formed by compounding water, glycerin, dendrobium stem extract, aloe barbadensis leaf extract, sophora flavescens root extract, lycium barbarum fruit extract and echinacea purpurea extract.
3. The essence containing polypeptide according to claim 2, wherein: the water, the glycerin, the stem extract of the dendrobium nobile lindl, the leaf extract of the aloe barbadensis, the root extract of the sophora flavescens ait, the fruit extract of the lycium barbarum and the echinacea purpurea extract are compounded into a mixture, and the mixture comprises the following components in percentage by weight: 60-80% of water, 15-25% of glycerol, 2-6% of stem extract of dendrobium stem, 1-3% of aloe barbadensis leaf extract, 1-3% of root extract of sophora flavescens ait, 0.5-2% of wolfberry fruit extract of Ningxia and 0.5-1% of echinacea purpurea extract.
4. The essence containing polypeptide according to claim 1, wherein: the anti-allergic agent is prepared from the following components in parts by weight:
2-5 parts of a mixture formed by compounding water, glycerol, trehalose, an ophiopogon root extract, a twisted cactus stem extract and a sophora flavescens root extract;
0.5-1 part of chlorphenamine maleate.
5. The essence containing polypeptide according to claim 4, wherein: the water, the glycerol, the trehalose, the radix ophiopogonis extract, the twisted cactus stem extract and the sophora flavescens root extract are compounded into a mixture, and the mixture comprises the following components in percentage by weight: 50-58% of water, 25-30% of glycerol, 6-8% of trehalose, 3-6% of an ophiopogon root extract, 3-6% of a twisted cactus stem extract and 3-6% of a sophora flavescens root extract.
6. The essence containing polypeptide according to claim 4, wherein: the Demin emulsion is prepared from the following components in parts by weight: 10: 1 butanediol, 1, 2-pentanediol and dihydrooat acyl anthranilic acid.
7. The essence containing polypeptide according to claim 1, wherein: the plant preservative is prepared from the following components in parts by weight:
0.5-2 parts of a mixture compounded by artemisia capillaris flower extract and clove flower extract.
8. The essence containing polypeptide according to claim 7, wherein: the weight ratio of the artemisia capillaris flower extract to the clove flower extract in the mixture compounded by the artemisia capillaris flower extract and the clove flower extract is 2: 1.
9. the essence containing polypeptide according to claim 1, wherein: the polypeptide is prepared from the following components in parts by weight:
10. a method for preparing the essence containing the polypeptide according to claim 1, wherein the method comprises the following steps: which comprises the following steps:
1) weighing Aloe barbadensis leaf extract raw materials, adding into a pot, adding thickener while stirring, and stirring to dissolve completely to obtain component A;
2) mixing humectant, anti-allergy agent, and other effective components at room temperature under stirring to obtain component B;
3) stirring and mixing the polypeptide components at room temperature to prepare a component C;
4) sequentially adding the component B and the component C into the component A, and uniformly stirring;
5) weighing antioxidant, plant antiseptic and aromatic in sequence, adding into a pan, and stirring well;
6) detecting pH value to 5.00-7.00, filtering with 200 mesh filter cloth and discharging.
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| CN111514055A (en) * | 2020-05-06 | 2020-08-11 | 深圳市健翔生物制药有限公司 | Cosmetic polypeptide composition granules with anti-inflammatory repair effect |
| CN112220705A (en) * | 2020-10-29 | 2021-01-15 | 北京瀚梅生物科技有限公司 | Moisturizing cosmetic with pure natural components |
| CN112245324A (en) * | 2020-10-29 | 2021-01-22 | 北京瀚梅生物科技有限公司 | Cosmetic with moisturizing function and preparation method and application thereof |
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| CN110339083A (en) * | 2019-08-21 | 2019-10-18 | 广东一华科技有限公司 | A kind of oligopeptides repairs Essence and its application method |
| CN110448509A (en) * | 2019-09-06 | 2019-11-15 | 奢脉国际化妆品(北京)有限公司 | A kind of polypeptide Essence and preparation method thereof having effects that Shu Min is repaired |
| CN110559206A (en) * | 2019-10-30 | 2019-12-13 | 长春市奢脉嘉天化妆品有限公司 | Multidirectional anti-wrinkle polypeptide essence and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110339083A (en) * | 2019-08-21 | 2019-10-18 | 广东一华科技有限公司 | A kind of oligopeptides repairs Essence and its application method |
| CN110448509A (en) * | 2019-09-06 | 2019-11-15 | 奢脉国际化妆品(北京)有限公司 | A kind of polypeptide Essence and preparation method thereof having effects that Shu Min is repaired |
| CN110559206A (en) * | 2019-10-30 | 2019-12-13 | 长春市奢脉嘉天化妆品有限公司 | Multidirectional anti-wrinkle polypeptide essence and preparation method thereof |
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| CN111514055A (en) * | 2020-05-06 | 2020-08-11 | 深圳市健翔生物制药有限公司 | Cosmetic polypeptide composition granules with anti-inflammatory repair effect |
| CN112220705A (en) * | 2020-10-29 | 2021-01-15 | 北京瀚梅生物科技有限公司 | Moisturizing cosmetic with pure natural components |
| CN112245324A (en) * | 2020-10-29 | 2021-01-22 | 北京瀚梅生物科技有限公司 | Cosmetic with moisturizing function and preparation method and application thereof |
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Application publication date: 20200428 |