CN111514055A - Cosmetic polypeptide composition granules with anti-inflammatory repair effect - Google Patents

Abstract

The invention belongs to the field of daily cosmetics, and particularly relates to a polypeptide composition granule with anti-inflammatory and repairing effects for cosmetics. The granules comprise the following components in percentage by mass: 0.2-8% of polypeptide composition, 2-20% of plant extract, 0.5-5% of bisabolol, 0.1-0.3% of safflower seed oil, 5-10% of humectant, 0.1-5% of emulsifier, 10-60% of filler and 5-30% of adhesive. The polypeptide composition contained in the anti-inflammatory repair granules can reduce the release of proinflammatory factors, improve the tolerance threshold of the skin and weaken the discomfort feeling of the skin on various stimulation pains and the like; the plant extract can effectively repair skin flushing, local swelling, acne and the like caused by skin inflammation. The active ingredients in the composition are matched and used together, and the effects of improving skin sensitivity and reducing skin inflammatory reaction are achieved through multiple ways and multiple layers.

Description

Cosmetic polypeptide composition granules with anti-inflammatory repair effect

Technical Field

The invention belongs to the field of daily cosmetics, and particularly relates to a polypeptide composition granule with anti-inflammatory and repairing effects for cosmetics.

Background

Neurogenic inflammation is the occurrence of an inflammatory response by inducing the release of neuropeptides (e.g., substance P) from the sensory nerve endings upon stimulation of the skin. Once the stimulus is removed, inflammation usually resolves rapidly. However, after the skin is inflamed, the threshold of the skin's response to external stimuli is lowered, which causes the skin to be in a continuous inflammatory state, resulting in damage to skin cells.

The human skin contains abundant sensory nerve fibers, and the nerve fibers enable the central nervous system to sense the skin condition at any time and respond to various chemical reactions, heat and physiological stimuli. When the barrier function of the skin is damaged, the transdermal water loss is increased, so that external irritants are easy to permeate, the afferent of sensory nerve signals of the skin is enhanced, the tolerance threshold is reduced, the weak irritation reaction to the outside is excessive, the immune response of the skin is activated, the reactivity of blood vessels is enhanced, the blood vessels are expanded, the infiltration of inflammatory cells is caused, and the skin has various skin discomfortable symptoms such as redness, telangiectasia, feeling of tightness, burning heat, pruritus and the like.

At present, the skin-care product for treating skin inflammation mainly comprises hexanediol, salicylic acid, allantoin and the like, wherein the hexanediol has an irritation effect after being contacted with the skin for a long time and can be absorbed by the skin, and a certain corrosivity can be caused at a high concentration. High concentrations of salicylic acid can irritate the skin and mucous membranes, and can react with proteins in body tissues, thus causing various problems such as skin barrier damage due to corrosive effects. Allantoin can help skin to resist inflammation, relieve and promote cell repair, but the addition amount is about 0.1% -0.2%, and stimulation reaction can be caused by excessive addition. The skin is inflamed, the normal physiological structure and the function of the skin are seriously damaged, on one hand, the natural tolerance threshold of the skin is gradually reduced, and on the other hand, scars are generated.

In view of the foregoing, there is a need in the art for a composition that increases the natural tolerance threshold of the skin and is effective in ameliorating inflammation; but also can repair scar skin after inflammation without generating other side effects.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention provides a polypeptide composition granule for cosmetics with anti-inflammatory repair efficacy.

The technical scheme adopted by the invention is as follows:

a polypeptide composition granule for cosmetics with anti-inflammatory and repairing effects comprises the following components: polypeptide composition, plant extract, bisabolol, safflower seed oil, humectant, filler and adhesive.

The cosmetic polypeptide composition granule with the anti-inflammatory and repair effects comprises the following components in percentage by mass based on the total mass of the granule: 0.2-13% of polypeptide composition, 2-20% of plant extract, 0.5-5% of bisabolol, 0.1-0.3% of safflower seed oil, 5-15% of humectant, 10-60% of filler and 5-30% of adhesive.

The cosmetic polypeptide composition granule with the anti-inflammatory and repair effects comprises the following components in percentage by mass based on the total mass of the granule: 0.2-8% of polypeptide composition, 2-15% of plant extract, 1-3% of bisabolol, 0.1-0.2% of safflower seed oil, 5-10% of humectant, 15-50% of filler and 8-25% of adhesive.

The active ingredients of the polypeptide composition comprise palmitoyl tetrapeptide-7, palmitoyl tripeptide-8, acetyl tetrapeptide-15 and copper peptide.

The polypeptide composition comprises the following components in percentage by mass: palmitoyl tetrapeptide-70.05% -0.3%, palmitoyl tripeptide-80.05% -0.5%, acetyl tetrapeptide-150.05% -0.3%, and copper peptide 0.05% -0.2%.

The plant extract is selected from radix Ophiopogonis extract, radix et caulis Opuntiae Dillenii extract, Sambucus nigra flower extract, and flos Matricariae Chamomillae extract.

The plant extract is selected from radix Ophiopogonis extract 0.05-5%, radix et caulis Opuntiae Dillenii extract 0.05-3%, Sambucus nigra flower extract 0.05-2%, and flos Matricariae Chamomillae extract 0.05-5%.

The humectant is selected from one or more of butanediol, glycerol, hydrolyzed sodium hyaluronate, trehalose, 1, 5-pentanediol and erythritol.

The filler is selected from one or more of starch, dextrin, lactose, anhydrous glucose and sorbitol.

The adhesive is selected from one or more of starch slurry and hydroxypropyl methyl cellulose.

The preparation method of the cosmetic polypeptide composition granules with the anti-inflammatory repair effect comprises the following steps:

the method comprises the following steps: respectively sieving palmitoyl tetrapeptide-7, palmitoyl tripeptide-8, acetyl tetrapeptide-15, copper peptide, radix Ophiopogonis extract, radix et caulis Opuntiae Dillenii extract, and flos Sambuci Williamsii extract with 120 mesh sieve;

step two: preparing the weighed adhesive into 5% aqueous solution;

step three: weighing palmitoyl tetrapeptide-7, palmitoyl tripeptide-8, acetyl tetrapeptide-15, copper peptide, radix ophiopogonis extract, twisted cactus extract, Sambucus nigra flower extract, chamomile extract, and a proper amount of bisabolol, safflower seed oil, humectant and filler, which are obtained by sieving in the step one, placing into a mixer, and uniformly mixing to obtain mixed powder;

step four: granulating the uniformly mixed powder in a dry granulating machine, adding an adhesive into the granulated granules and powder, fully and uniformly mixing to prepare granules, and drying the granules to prepare a semi-finished product;

step five: and (4) sieving the semi-finished product by a 14-mesh sieve to obtain granules, namely the product.

Palmitoyl tetrapeptide-7 can be used for compacting skin by stimulating laminin (LamininV) IV and collagen VII, reducing interleukin (interleukin-6) production, eliminating inflammation, and preventing wrinkle formation, relaxation and uneven skin color.

Palmitoyl tripeptide-8 has highly specific anti-inflammatory activity, can effectively prevent and relieve inflammation and symptoms caused by chemical stimulation, is particularly suitable for nursing sensitive and intolerant skin, and potentially reduces the generation of melanin.

The acetyl tetrapeptide-15 is a polypeptide capable of improving the natural tolerance threshold of the skin, and can relieve discomfort caused by cosmetics and skin treatment means by improving the tolerance of the skin to environmental factors, thereby achieving the purpose of relieving skin sensitivity.

The copper peptide can promote the regeneration of skin epithelial tissues, recover the youth of the skin, reduce coarse wrinkles and scars, improve the elasticity of the skin, proliferate keratinocytes and fibroblasts, thicken the subcutaneous tissues, enable the skin to be not fragile and sensitive any more, and increase the elasticity and toughness of the skin.

The radix Ophiopogonis extract is derived from radix Ophiopogonis, is rich in polyfructose active ingredients, and can reduce the disintegration of stratum corneum and achieve the moisturizing effect by enhancing the adhesion of the upper layer of epidermis and recombining the barrier function of skin.

The Opuntia Dillenii extract has antibacterial effect, sitosterol contained in Opuntia Dillenii is antiinflammatory active component, triterpenoid saponin is analgesic active component, and Opuntia Dillenii has antiinflammatory and analgesic effects.

The extract of Sambucus nigra flower is rich in anti-allergic components such as choline and rutin. Can effectively prevent histamine from combining with melanocyte, and inhibit skin inflammation and melanin excessive production.

The chamomile extract contains flavonoid compounds, amino acids and other components, so that the water-oil balance of the skin is regulated to a certain degree, meanwhile, the moisture can be effectively supplemented to the skin, the skin is in a relatively stable state, and the problem of skin redness is reduced.

The bisabolol has good compatibility with skin, reduces skin inflammation, relieves skin acne, prevents acne, improves anti-irritation capability of skin, and repairs skin with inflammation injury.

The safflower seed oil contains a large amount of vitamin E, can inhibit oxidation reaction of human body, delay skin aging, prevent pigment from depositing on skin surface layer, and has anti-inflammatory and wound healing promoting effects.

Compared with the prior art, the invention has the beneficial effects that:

(1) according to the cosmetic polypeptide composition granule with the anti-inflammatory repair effect, the palmitoyl tripeptide-8 and acetyl tetrapeptide-15 can reduce the release of proinflammatory factors, improve the tolerance threshold of the skin, effectively repair flushing, local swelling, acne and the like of the skin caused by inflammation, effectively reduce skin inflammation reaction, and play a synergistic role in repairing inflammation.

(2) The polypeptide composition granules with the anti-inflammatory and repairing effects are prepared by compounding the ophiopogon root extract, the prickly pear extract, the American elderberry flower extract and the chamomile extract, have the effects of relieving and resisting inflammation, can effectively relieve the invasion of external factors such as improper chemicals such as sunshine, cold and alcohol and emotion to skin, protect the skin from being damaged, improve the immunity of the skin, maintain the health state of the skin, can isolate ultraviolet rays, activate skin tissues and promote blood circulation, have the functions of relieving, softening and moistening the skin, promote the regeneration of the skin, can diminish inflammation, relieve and repair the skin and improve the sensitivity of the skin.

(3) The cosmetic polypeptide composition granules with the anti-inflammatory repair effect can promote the regeneration of skin epithelial tissues, so that keratinocytes and fibroblasts proliferate, and scars left after inflammation are repaired. Palmitoyl tetrapeptide-7 strengthens the skin by stimulating collagen, reconstituting healthy skin.

(4) The invention selects the granule formulation to dissolve quickly; the use, the storage and the transportation are more convenient. Compared with a water aqua, the water aqua is mostly directly used, the dosage is not easy to control, microorganisms are easy to breed, and the water aqua is not beneficial to the health of consumers. The granule reduces the problems of denaturation, reaction, volatilization, loss and the like of effective components caused by long-time use, storage and transportation, enhances the stability of the preparation, improves the product quality and has stronger effect. Meanwhile, the oxidation, the dissipation and the reaction of the thermosensitive components can be effectively prevented, and the biological activity of the active substances is completely reserved. In addition, the granule uses less solvent, and can reduce the pollution to the environment. Therefore, the invention can improve the purity of the active substance, save the solvent, reduce the energy consumption, shorten the processing period and greatly reduce the cost.

Detailed Description

The above-described aspects of the invention are further illustrated by the following specific embodiments in the form of examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples.

Example 1 anti-inflammatory repair granules

Table 1 anti-inflammatory and repair granules

The preparation of this example was carried out according to the following steps:

the method comprises the following steps: respectively sieving palmitoyl tetrapeptide-7, palmitoyl tripeptide-8, acetyl tetrapeptide-15, copper peptide, radix Ophiopogonis extract, radix et caulis Opuntiae Dillenii extract, and flos Sambuci Williamsii extract with 120 mesh sieve;

step two: preparing the weighed adhesive into 5% aqueous solution;

step three: weighing palmitoyl tetrapeptide-7, palmitoyl tripeptide-8, acetyl tetrapeptide-15, copper peptide, radix ophiopogonis extract, twisted cactus extract, Sambucus nigra flower extract, chamomile extract, and a proper amount of bisabolol, safflower seed oil, humectant and filler, which are obtained by sieving in the step one, placing into a mixer, and uniformly mixing to obtain mixed powder;

step four: granulating the uniformly mixed powder in a dry granulating machine, adding an adhesive into the granulated granules and powder, fully and uniformly mixing to prepare granules, and drying the granules to prepare a semi-finished product;

step five: and (4) sieving the semi-finished product by a 14-mesh sieve to obtain granules, namely the product.

Example 2 anti-inflammatory repair granules

TABLE 2 anti-inflammatory and repair granules

The preparation method of the embodiment is the same as that of the first embodiment.

Example 3 anti-inflammatory repair granules table 3 anti-inflammatory repair granules

The preparation method of the embodiment is the same as that of the first embodiment.

Example 4 anti-inflammatory repair granules table 4 anti-inflammatory repair granules

The preparation method of the embodiment is the same as that of the first embodiment.

Example 5 anti-inflammatory repair granules table 5 anti-inflammatory repair granules

The preparation method of the embodiment is the same as that of the first embodiment.

Comparative example 1 anti-inflammatory repair granules table 6 anti-inflammatory repair granules

Comparative example 2 anti-inflammatory repair granules table 7 anti-inflammatory repair granules

Comparative example 3 anti-allergic repair granules table 8 anti-inflammatory repair granules

Comparative example 4 anti-allergic repair granules

TABLE 9 anti-inflammatory repair granules

Test example 1 test for skin sensitivity against capsaicin

Selecting 100 healthy volunteers, half of male and half of female, the age of which is 20-45 years old, randomly dividing the volunteers into 10 groups of 10 persons, wherein each group comprises 5 males and 5 females; one group served as a blank control, and the remaining groups of volunteers were left-handed to capsaicin treatment, and then applied to the capsaicin-coated areas using examples 1-5 and comparative examples 1-4, respectively. Subjects were asked about a tingling sensation 24 hours after the treatment, and scored by 5 points (1 point was no tingling sensation, 2 point was mild stinging, 3 point was moderate stinging, 4 point was severe stinging, and 4 point was extreme stinging), and the rate of change in the skin tolerance threshold before and after the treatment was calculated, and the results are shown in table 10.

TABLE 10 variation of the skin tolerance threshold before and after treatment for different groups of administration

The results show that the present invention can improve the tolerance threshold of skin itching, stinging and hot and uncomfortable feelings caused by capsaicin. As can be seen from Table 10, example 5 gave the best results, up to 35.4%, whereas comparative examples 1-4, lacking the components of the composition, all had a reduced anti-irritant effect, demonstrating a significant synergistic effect of the individual active ingredients in the composition.

Test example 2 sensitive skin repair test

300 sensitive muscle patients, aged 20-35 years, were selected and randomized into 10 groups of 30 patients each, and after washing their face in the morning and evening, the patients were treated with each of examples 1-5, comparative examples 1-4, and placebo for 4 weeks, each morning and evening being smeared once. The treatment condition of the patient and the adverse reaction condition during the treatment process are recorded in detail before and after the treatment.

Anti-inflammatory effect therapeutic criteria:

and (3) curing: the symptoms of skin redness, itching and pain completely disappear.

The method has the following advantages: the symptoms of skin redness, itching and pain are basically disappeared.

And (4) invalidation: the symptoms of skin redness, itching and pain are the same or aggravated.

Effective rate (cure number + effective number)/observation number × 100%.

The healing effect standard of scar repair:

and (3) curing: the red pockmarks of the skin completely disappeared.

The method has the following advantages: the skin had a few pale red pocks.

And (4) invalidation: the red pock marks on the skin are either earlier or worse.

Effective rate (cure number + effective number)/observation number × 100%.

As a result:

after 4 weeks of treatment, the anti-inflammatory effect and scar repair efficacy of each group were compared, and the efficacy of the administration groups of examples 1-5 was much higher than that of the comparative examples 1-4 and the placebo group. The results show that compared with comparative examples 1-4, the skin inflammation can be more effectively improved and the scar skin can be more effectively repaired after the active ingredients with different action mechanisms are combined.

The above detailed description is specific to possible embodiments of the present invention, and the embodiments are not intended to limit the scope of the present invention, and all equivalent implementations or modifications that do not depart from the scope of the present invention should be included within the scope of the present invention.

Claims (11)

1. A polypeptide composition granule for cosmetics with anti-inflammatory and repair effects, wherein the components in the granule comprise: polypeptide composition, plant extract, bisabolol, safflower seed oil, humectant, filler and adhesive.

2. The granule according to claim 1, wherein the mass percentage ranges of the components in the granule are as follows based on the total mass of the granule: 0.2-13% of polypeptide composition, 2-20% of plant extract, 0.5-5% of bisabolol, 0.1-0.3% of safflower seed oil, 5-15% of humectant, 10-60% of filler and 5-30% of adhesive.

3. The granule according to claim 2, wherein the mass percentage ranges of the components in the granule are as follows based on the total mass of the granule: 0.2-8% of polypeptide composition, 2-15% of plant extract, 1-3% of bisabolol, 0.1-0.2% of safflower seed oil, 5-10% of humectant, 15-50% of filler and 8-25% of adhesive.

4. The granule according to any one of claims 1 to 3, wherein the active ingredients of the polypeptide composition comprise: palmitoyl tetrapeptide-7, palmitoyl tripeptide-8, acetyl tetrapeptide-15, and copper peptide.

5. The granule according to claim 4, wherein the polypeptide composition is present in the range of, by weight: palmitoyl tetrapeptide-70.05% -3%, palmitoyl tripeptide-80.05% -5%, acetyl tetrapeptide-150.05% -3% and copper peptide 0.05% -2%.

6. The granule according to any one of claims 1 to 3, wherein the plant extract is selected from the group consisting of an extract of the root of Ophiopogon japonicus, an extract of Opuntia ficus-indica, an extract of the flower of Sambucus nigra, and an extract of Matricaria chamomilla.

7. The granule of claim 6, wherein the plant extract is selected from the group consisting of 0.05-5% of radix Ophiopogonis extract, 0.05-3% of Opuntia ficus-indica extract, 0.05-2% of Sambucus nigra flower extract, and 0.05-5% of Matricaria chamomilla flower extract.

8. The granule according to any one of claims 1 to 3, wherein the humectant is selected from one or more of butylene glycol, glycerin, hydrolyzed sodium hyaluronate, trehalose, 1, 5-pentanediol, erythritol.

9. The granule according to any of claims 1 to 3, wherein the filler is selected from one or more of starch, dextrin, lactose, anhydrous glucose, sorbitol.

10. The granule according to any of claims 1-3, wherein the binder comprises at least one of starch slurry, hydroxypropyl methylcellulose.

11. A process for preparing a granulate according to any of claims 1 to 3, wherein: the method comprises the following steps:

the method comprises the following steps: respectively sieving palmitoyl tetrapeptide-7, palmitoyl tripeptide-8, acetyl tetrapeptide-15, copper peptide, radix Ophiopogonis extract, radix et caulis Opuntiae Dillenii extract, and flos Sambuci Williamsii extract with 120 mesh sieve;

step two: preparing the weighed adhesive into 5% aqueous solution;

step three: weighing palmitoyl tetrapeptide-7, palmitoyl tripeptide-8, acetyl tetrapeptide-15, copper peptide, radix ophiopogonis extract, twisted cactus extract, Sambucus nigra flower extract, chamomile extract, and a proper amount of bisabolol, safflower seed oil, humectant and filler, which are obtained by sieving in the step one, placing into a mixer, and uniformly mixing to obtain mixed powder;

step four: granulating the uniformly mixed powder in a dry granulating machine, adding an adhesive into the granulated granules and powder, fully and uniformly mixing to prepare granules, and drying the granules to prepare a semi-finished product;

step five: and (4) sieving the semi-finished product by a 14-mesh sieve to obtain granules, namely the product.