CN111991263A - Composition for tightening skin and preparation method and application thereof - Google Patents
Composition for tightening skin and preparation method and application thereof Download PDFInfo
- Publication number
- CN111991263A CN111991263A CN202010966545.3A CN202010966545A CN111991263A CN 111991263 A CN111991263 A CN 111991263A CN 202010966545 A CN202010966545 A CN 202010966545A CN 111991263 A CN111991263 A CN 111991263A
- Authority
- CN
- China
- Prior art keywords
- skin
- tightening
- essence
- composition
- firming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title abstract description 14
- LODWEXDBRZBADB-XEVVZDEMSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O LODWEXDBRZBADB-XEVVZDEMSA-N 0.000 claims abstract description 26
- 229940094912 palmitoyl tripeptide-5 Drugs 0.000 claims abstract description 26
- 229940064062 alpha-glucan oligosaccharide Drugs 0.000 claims abstract description 23
- 229920001202 Inulin Polymers 0.000 claims abstract description 20
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 20
- 229940029339 inulin Drugs 0.000 claims abstract description 20
- 229920005862 polyol Polymers 0.000 claims abstract description 13
- 150000003077 polyols Chemical class 0.000 claims abstract description 13
- 239000002904 solvent Substances 0.000 claims abstract description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 50
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 20
- 235000011187 glycerol Nutrition 0.000 claims description 20
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 14
- 229940035437 1,3-propanediol Drugs 0.000 claims description 14
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 14
- 239000002562 thickening agent Substances 0.000 claims description 13
- 230000002335 preservative effect Effects 0.000 claims description 10
- 239000002738 chelating agent Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- 239000003755 preservative agent Substances 0.000 claims description 8
- 239000004909 Moisturizer Substances 0.000 claims description 6
- 230000001333 moisturizer Effects 0.000 claims description 6
- 239000006071 cream Substances 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 239000000499 gel Substances 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 abstract description 19
- 108010035532 Collagen Proteins 0.000 abstract description 19
- 229920001436 collagen Polymers 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 14
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 4
- 210000003491 skin Anatomy 0.000 description 121
- 239000000686 essence Substances 0.000 description 60
- 239000000047 product Substances 0.000 description 16
- 229920002385 Sodium hyaluronate Polymers 0.000 description 15
- 229940010747 sodium hyaluronate Drugs 0.000 description 15
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 210000004207 dermis Anatomy 0.000 description 10
- 230000003020 moisturizing effect Effects 0.000 description 10
- 239000003906 humectant Substances 0.000 description 9
- 238000003756 stirring Methods 0.000 description 9
- 150000005846 sugar alcohols Polymers 0.000 description 9
- 230000032683 aging Effects 0.000 description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 8
- 230000009286 beneficial effect Effects 0.000 description 8
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 6
- 244000052616 bacterial pathogen Species 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 230000003712 anti-aging effect Effects 0.000 description 5
- 230000002421 anti-septic effect Effects 0.000 description 5
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 5
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 5
- 230000037303 wrinkles Effects 0.000 description 5
- 229920001285 xanthan gum Polymers 0.000 description 5
- 239000000230 xanthan gum Substances 0.000 description 5
- 229940082509 xanthan gum Drugs 0.000 description 5
- 235000010493 xanthan gum Nutrition 0.000 description 5
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- 229960003471 retinol Drugs 0.000 description 4
- 235000020944 retinol Nutrition 0.000 description 4
- 239000011607 retinol Substances 0.000 description 4
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 3
- 229960000458 allantoin Drugs 0.000 description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 230000002500 effect on skin Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- 229940043375 1,5-pentanediol Drugs 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- 241000512259 Ascophyllum nodosum Species 0.000 description 2
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 2
- 108010087806 Carnosine Proteins 0.000 description 2
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229940044199 carnosine Drugs 0.000 description 2
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 2
- 239000000498 cooling water Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 239000002798 polar solvent Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 230000008467 tissue growth Effects 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- WSGCRSMLXFHGRM-DEVHWETNSA-N (2s)-2-[[(2s)-6-amino-2-[[(2s,3r)-2-[[(2s,3r)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O WSGCRSMLXFHGRM-DEVHWETNSA-N 0.000 description 1
- AJLNZWYOJAWBCR-OOPVGHQCSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O AJLNZWYOJAWBCR-OOPVGHQCSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical compound CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 description 1
- 229940120145 3-o-ethylascorbic acid Drugs 0.000 description 1
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 244000025352 Artocarpus heterophyllus Species 0.000 description 1
- 235000008725 Artocarpus heterophyllus Nutrition 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 101710125298 Beta-defensin 2 Proteins 0.000 description 1
- 102100038326 Beta-defensin 4A Human genes 0.000 description 1
- 101710176951 Beta-defensin 4A Proteins 0.000 description 1
- 241000123846 Buddleja officinalis Species 0.000 description 1
- BYUQATUKPXLFLZ-UIOOFZCWSA-N CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 BYUQATUKPXLFLZ-UIOOFZCWSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000000340 Glucosyltransferases Human genes 0.000 description 1
- 108010055629 Glucosyltransferases Proteins 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241000234479 Narcissus Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 244000235659 Rubus idaeus Species 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- 241000222481 Schizophyllum commune Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 244000062793 Sorghum vulgare Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000589499 Thermus thermophilus Species 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 244000047670 Viola x wittrockiana Species 0.000 description 1
- 235000004031 Viola x wittrockiana Nutrition 0.000 description 1
- 229940095094 acetyl hexapeptide-8 Drugs 0.000 description 1
- 108010006338 acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide Proteins 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 238000007036 catalytic synthesis reaction Methods 0.000 description 1
- 229940099417 ceramide 2 Drugs 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 230000037319 collagen production Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000006957 competitive inhibition Effects 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229940093441 palmitoyl oligopeptide Drugs 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 229940054168 pomegranate fruit extract Drugs 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229940074410 trehalose Drugs 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention provides a composition for tightening skin, and a preparation method and application thereof. The firming skin composition comprises the following components in percentage by mass based on 100% of the total mass of the firming skin composition: palmitoyl tripeptide-5: 0.1-1.5%, preferably 0.3-1%; α -glucan oligosaccharide: 5-20%, preferably 8-15%; inulin: 5-15%, preferably 8-15%; polyol: 40-60%, preferably 40-53%; solvent: 9 to 39.9%, preferably 16 to 36.7%. The composition for tightening skin and the tightening essence can increase collagen of skin, keep balance of skin strains, keep healthy state of skin and have remarkable effect of tightening skin. Furthermore, the preparation methods of the composition for tightening skin and the tightening essence are simple and feasible, and the raw materials are easy to obtain, so that the composition for tightening skin and the tightening essence are suitable for mass production.
Description
Technical Field
The invention relates to a composition for tightening skin, a preparation method and an application thereof, in particular to a composition for tightening skin, a preparation method and an application thereof, and tightening essence containing the composition for tightening skin, and belongs to the field of cosmetics.
Background
In the world, people's lives are plagued by the problems of skin aging and looseness. Generally, skin aging and skin relaxation are caused by the following four factors: natural aging of human body: loss of collagen with age causes aging and laxity of the skin; the microbial balance of the skin is disrupted, and the skin is also subject to aging and laxity; exposure to a contaminated environment, exposure to sunlight also causes the aging and laxity of the skin; gravity, etc. can also cause the skin to sag and loosen.
Among them, collagen is mainly produced by fibroblasts of the dermis layer, is a main component of the dermis layer, and can maintain the structure of the skin and endow the skin with toughness and elasticity. The collagen content and distribution determine the youth or not of the skin. However, an abnormal decrease in collagen content causes thinning of the dermal layer, skin relaxation, loss of elasticity, and wrinkles. Furthermore, human skin is an ecosystem consisting of a wide variety of bacterial, fungal and viral habitats. Despite frequent washing and exposure to bacteria-rich objects, our personal skin microbial environment remains highly stable over time. However, if the balance of the skin's microbiome is disrupted, the skin may also relax, lose elasticity, and wrinkle.
In order to prevent skin from sagging, losing elasticity, forming wrinkles, and the like, and to keep skin young, anti-aging products mixed with various components such as hydrolyzed collagen, hyaluronic acid, polypeptide, retinol and derivatives thereof have been proposed in the prior art. However, if these ingredients are used in large amounts, problems arise in the actual anti-aging effect, the feeling of use, and safety. If the molecular weight of the hydrolyzed collagen is too large, the hydrolyzed collagen is not easy to permeate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; the polypeptide and the retinol have certain irritation and safety risks to the skin, and the like.
Citation 1 provides an anti-aging cosmetic composition for improving skin elasticity, comprising the following components in parts by weight: retinol palmitate: 0.001-0.5 parts; wrapping retinol: 0.001-2 parts; fermentation product: 0.0001-20 parts; nicotinamide: 2-4 parts; citrus peel extract: 2-4 parts; soluble proteoglycan: 0.1-5 parts; artocarpus heterophyllus leaf/stem extract: 0.1-5 parts; carnosine: 0.001-0.2 parts; 3-o-ethyl ascorbic acid: 0.001-3 parts. The use of various functional ingredients in the composition results in high cost, and the use of encapsulated retinol causes certain irritation and safety risk to the skin.
Citation 2 discloses an anti-aging and repairing skin care composition containing symbiotic bacteria combined fermentation product, essence milk, and a preparation method and application thereof. The anti-aging and repairing skin care composition comprises symbiotic bacteria combined leavening, decarboxylated carnosine, palmitoyl pentapeptide-4, tocopherol acetate, a buddleja officinalis extract, resveratrol, a pomegranate fruit extract and a narcissus bulb extract; the symbiotic bacteria of the symbiotic bacteria combined fermentation product comprise the combination of schizophyllum commune, thermus thermophilus, saccharomycetes and lactobacillus; the fermentation raw materials of the symbiotic bacteria combined fermentation product comprise rice, Sichuan millet seeds, ginseng, kelp and raspberry. Wherein also the use of a plurality of active ingredients results in a cost which is too high and wherein the use of a larger number of bacterial species may further disrupt the microbial balance of the skin.
Therefore, it is an urgent technical problem to be solved to research a composition for skin tightening that can supplement collagen and promote the propagation of beneficial bacteria in the skin, thereby protecting and balancing the flora of the skin and slowing down the aging and laxity of the skin.
Cited documents:
cited document 1: CN111297724A
Cited document 2: CN111297791A
Disclosure of Invention
Problems to be solved by the invention
Aiming at the technical problems in the prior art, for example: the invention provides a composition for tightening skin and a tightening essence containing the composition for tightening skin, and aims to solve the problems that the dermis layer is thinned due to abnormal reduction of the content of collagen, and the skin is loosened, loses elasticity, wrinkles and the like caused by damage of the microbial group balance of the skin. The composition for tightening skin and the tightening essence can solve the problem of skin aging and relaxation caused by the problem and enable the skin to be tightened.
Furthermore, the invention also provides a preparation method of the composition for tightening skin and the tightening essence, and the two preparation methods are simple and easy to implement and the raw materials are easy to obtain.
Means for solving the problems
The invention provides a composition for firming skin, which comprises the following components in percentage by mass based on 100% of the total mass of the composition for firming skin:
palmitoyl tripeptide-5: 0.1-1.5%, preferably 0.3-1%;
α -glucan oligosaccharide: 5-20%, preferably 8-15%;
inulin: 5-15%, preferably 8-15%;
polyol: 40-60%, preferably 40-53%;
solvent: 9 to 39.9%, preferably 16 to 36.7%.
The firming skin composition according to the present invention, wherein the mass ratio of the palmitoyl tripeptide-5, the α -glucan oligosaccharide, the inulin, and the polyol is 1:10 to 30:40 to 90.
The firming skin composition according to the present invention, wherein the polyhydric alcohol comprises glycerin and 1, 3-propanediol; wherein, the addition amount of the glycerin is 35-45%, preferably 35-43% based on the total mass of the firming skin composition as 100%; the 1, 3-propanediol is added in an amount of 5-15%, preferably 5-10%.
The composition for tightening skin, provided by the invention, is characterized in that the mass ratio of glycerin to 1, 3-propylene glycol is 3-6: 1.
The invention also provides a method for preparing the firming skin composition, which comprises the step of mixing the components of the firming skin composition.
The present invention also provides a use of the firming skin composition according to the present invention in a skin care product, preferably, the skin care product comprises a lotion, cream, emulsion, gel or essence.
The invention also provides a firming essence which comprises the firming skin composition; preferably, the firming skin composition is added in an amount of 0.1 to 5%, preferably 1 to 3%, based on 100% by weight of the total firming essence.
The tightening essence provided by the invention further comprises one or a combination of more than two of a moisturizing agent, a skin conditioning agent, a thickening agent, a chelating agent and a preservative.
The tightening essence provided by the invention is characterized in that the addition amount of the humectant is 3.011-14.4%, preferably 6.1-11.4%, based on 100% of the total weight of the tightening essence; the addition amount of the skin conditioner is 0.05-0.12%, preferably 0.08-0.1%; the addition amount of the thickening agent is 0.01-0.2%, preferably 0.05-0.2%; the addition amount of the chelating agent is 0.01-0.05%, preferably 0.02-0.04%; the addition amount of the preservative is 0.05-1.2%, preferably 0.05-0.6%.
The invention also provides a preparation method of the tightening essence, which comprises the step of mixing the components of the tightening essence.
ADVANTAGEOUS EFFECTS OF INVENTION
The composition for tightening skin and the tightening essence can increase collagen of skin, keep balance of skin strains, keep healthy state of skin and have remarkable effect of tightening skin.
Furthermore, the preparation methods of the composition for tightening skin and the tightening essence are simple and feasible, and the raw materials are easy to obtain, so that the composition for tightening skin and the tightening essence are suitable for mass production.
Detailed Description
Various exemplary embodiments, features and aspects of the invention will be described in detail below. The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.
All units used in the specification are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include systematic errors inevitable in industrial production.
In the present specification, "%" denotes mass% unless otherwise specified.
In the present specification, the meaning of "may" includes both the meaning of performing a certain process and the meaning of not performing a certain process.
In the present specification, reference to "some particular/preferred embodiments," "other particular/preferred embodiments," "embodiments," and the like, means that a particular element (e.g., feature, structure, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the described elements may be combined in any suitable manner in the various embodiments.
In the present specification, the numerical range represented by "numerical value a to numerical value B" means a range including the end point numerical value A, B.
In the present specification, the term "water" includes any available water that can be used in the cosmetic field, such as deionized water, distilled water, ion-exchanged water, double distilled water, high purity water, and purified water.
In the present specification, the "room temperature" may be 10 to 40 ℃.
First aspect
The first aspect of the invention provides a firming skin composition, which comprises the following components in percentage by mass based on 100% of the total mass of the firming skin composition:
palmitoyl tripeptide-5: 0.1-1.5%, preferably 0.3-1%;
α -glucan oligosaccharide: 5-20%, preferably 8-15%;
inulin: 5-15%, preferably 8-15%;
polyol: 40-60%, preferably 40-53%;
solvent: 9 to 39.9%, preferably 16 to 36.7%.
Among them, palmitoyl tripeptide-5 is a chemical substance capable of activating a tissue growth factor, which can accelerate collagen production and wrinkle repair. Palmitoyl tripeptide-5 produces collagen by tissue growth factor (TGF- β) mimicking the human body's own mechanism. Therefore, palmitoyl tripeptide-5 is an excellent ingredient for tightening the skin, and does not irritate the skin.
Specifically, in the present invention, palmitoyl tripeptide-5 is added in an amount of 0.1 to 1.5%, preferably 0.3 to 1%, more preferably 0.5 to 1%, and further preferably 0.6 to 1%, based on 100% by mass of the total skin-tightening composition; the solubility of palmitoyl tripeptide-5 in water is low, if the addition amount of palmitoyl tripeptide-5 is more than 1.5%, the palmitoyl tripeptide-5 is precipitated, and if the content of palmitoyl tripeptide-5 is more than 1%, a small amount of palmitoyl tripeptide-5 is precipitated; if the amount of palmitoyl tripeptide-5 added is less than 0.1%, the effect is not as good. Specifically, in the present invention, the palmitoyl tripeptide-5 may be added in an amount of 0.2%, 0.4%, 0.7%, 0.8%, 0.9%, 1.2%, or the like.
The alpha-glucan oligosaccharide is obtained from a plant substrate through enzyme catalytic synthesis, and is specifically operated by using glucosyltransferase to react sucrose with maltose; the alpha-glucan oligosaccharide can be selectively absorbed by beneficial bacteria, promotes the growth and the propagation of the beneficial bacteria without being utilized by pathogenic bacteria, and competitively inhibits pathogenic bacteria, thereby recovering the stable population number of the beneficial bacteria on the skin. The alpha-glucan oligosaccharide acts on the skin and can activate the gene expression of beta-defensin 2. The beta-alexin 2 is a micromolecular antibacterial peptide and has good killing effect on pathogenic bacteria on the skin, so that the reproduction of the pathogenic bacteria is inhibited.
Specifically, in the present invention, the amount of α -glucan oligosaccharide added is 5 to 20%, preferably 8 to 15%, more preferably 10 to 15%, and further preferably 12 to 15%, based on 100% by mass of the total of the firming skin composition; if the amount of the alpha-glucan oligosaccharide added is less than 5%, no effect is obtained, if the amount of the alpha-glucan oligosaccharide added is more than 20%, the product is relatively sticky, and if the amount of the alpha-glucan oligosaccharide added is more than 15%, the product is slightly sticky. Specifically, in the present invention, the α -glucan oligosaccharide may be added in an amount of 6%, 7%, 9%, 11%, 13%, 14%, 18%, etc.
Inulin can be selectively absorbed by beneficial bacteria, promotes the growth and the propagation of the beneficial bacteria without being utilized by pathogenic bacteria, generates competitive inhibition on pathogenic bacteria, and further restores the population number of the skin beneficial bacteria to be stable. The present inventors have found that the use of inulin can further slow the aging laxity of the skin.
Specifically, in the present invention, inulin is added in an amount of 5 to 15%, preferably 8 to 15%, more preferably 10 to 15%, and further preferably 12 to 15%, based on 100% by mass of the total of the firming skin composition; if the inulin is added in an amount of less than 5%, no effect is obtained; if the inulin is added in an amount of more than 15%, the texture of the product is affected. Specifically, in the present invention, the inulin may be added in an amount of 6%, 7%, 9%, 11%, 13%, 14%, etc.
Furthermore, the palmitoyl tripeptide-5, the alpha-glucan oligosaccharide and the inulin are used, and the three functional components can play a synergistic role, so that the generation of collagen and the propagation of beneficial bacteria of the skin are effectively promoted, and the aging and the relaxation of the skin are slowed down in two aspects of competitive performance of harmful flora.
The firming skin composition of the present invention further comprises a polyhydric alcohol, and the use of the polyhydric alcohol can exert the effects of palmitoyl tripeptide-5, α -glucan oligosaccharide, and inulin most effectively, and the use of the polyhydric alcohol can promote the dissolution of the active ingredient, and also has the effects of moisturizing and preserving.
Specifically, in the present invention, the amount of the polyhydric alcohol added is 40 to 60%, preferably 40 to 53%, more preferably 42 to 52%, and further preferably 45 to 50% based on 100% by mass of the total mass of the firming skin composition; when the content of the polyhydric alcohol is 40-60%, moisturizing and preservative effects can be achieved, when the content of the polyhydric alcohol is lower than 40%, preservative effects cannot be achieved well, and when the content of the polyhydric alcohol exceeds 60%, the skin feel is sticky. Specifically, in the present invention, the addition amount of the polyol may be 40%, 41%, 42%, 43%, 45%, 47%, 48%, 50%, 51%, 52%, etc.
Further, in order to maximize the efficacy of the firming skin composition of the present invention, the mass ratio of the palmitoyl tripeptide-5, the α -glucan oligosaccharide, inulin, and the polyol is 1:10-30:10-30:40-90, for example: 12 to 25:45 to 85, 1:15 to 22:48 to 82, 1:15 to 20:50 to 80, and the like.
In addition, the present invention requires the use of a solvent to dissolve the efficacy components in the skin-tightening composition, specifically, the solvent is added in an amount of 9 to 39.9%, preferably 16 to 36.7%, more preferably 17 to 35%, and further preferably 19 to 35%. Specifically, in the present invention, the solvent may be added in an amount of 12%, 18%, 22%, 24%, 26%, 28%, 30%, 33%, 35%, 37%, etc.
Further, the solvent may be a polar solvent that may be used in some cosmetics commonly used in the art, such as: water and the like.
In some specific embodiments, in the present invention, the polyhydric alcohol may include glycerin and 1, 3-propanediol. Wherein, the glycerol has good moisturizing effect; the 1, 3-propylene glycol is a natural product, does not cause skin irritation or allergy, and can enhance the moisturizing performance of the product.
Specifically, the glycerin is added in an amount of 35 to 45%, preferably 35 to 43%, more preferably 36 to 42%, and further preferably 37 to 40% based on 100% by mass of the total firming skin composition; the 1, 3-propanediol is added in an amount of 5 to 15%, preferably 5 to 10%, more preferably 6 to 10%, and further preferably 8 to 10%. The addition amount of glycerol and 1, 3-propylene glycol is 5-15%, so as to achieve antiseptic effect, and no antiseptic is required. Specifically, the addition amount of the glycerin may be 35%, 36%, 37%, 38%, 39%, 41%, etc.; the addition amount of the 1, 3-propanediol is 7%, 9%, 11%, 12%, 13%, 14% and the like.
Further, in order to exert the efficacy of the composition for firming skin most effectively, the mass ratio of the glycerin to the 1, 3-propanediol is 3-6: 1, such as: 3.5:1, 4:1, 4.5:1, 5:1, 5.5:1, etc.
Further, the first aspect of the present invention also provides a method for preparing the firming skin composition according to the present invention, which comprises the step of mixing the components of the firming skin composition.
In some specific embodiments, the mixing is performed at room temperature. During the mixing process, the stirring mode can be used to make the mixing more uniform.
Second aspect of the invention
A second aspect of the present invention provides the use of the firming skin composition according to the first aspect of the present invention in a skin care product, preferably, the skin care product comprises a lotion, cream, emulsion, gel or essence.
In some specific embodiments, the present invention also provides a tightening essence comprising the tightening skin composition according to the first aspect of the present invention; preferably, the firming skin composition is added in an amount of 0.1 to 5%, preferably 1 to 4%, based on 100% by weight of the total firming essence, for example: 0.5%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4.5%, etc. Composition if the amount of the composition for firming skin is less than 0.1%, the effect may not be significant; if the amount of the composition for tightening skin is more than 5%, there is a risk of precipitation and thus the effect is not achieved, resulting in waste and increased cost.
In some specific embodiments, the tightening serum further comprises one or a combination of two or more of a moisturizer, a skin conditioner, a thickener, a chelating agent, and a preservative. The firming essence disclosed by the invention is mild in formula composition, and the effect of the firming skin composition disclosed by the invention can be fully exerted. Specifically, the method comprises the following steps:
the addition amount of the humectant is 3.011-14.4%, preferably 6.1-11.4%, based on the total mass of the tightening essence being 100%. When the addition amount of the humectant is 3.011-14.4%, the humectant can play a role in moisturizing and moisturizing. In order to further exert the efficacy of the moisturizer, the amount of the moisturizer of the present invention added is preferably 4 to 14%, 5 to 13%, 6 to 12%, 7 to 11%, 8 to 10%, or the like. When the content of the humectant is less than 3.011%, the moisturizing effect is not obvious; when the content of the humectant is more than 14.4%, the firming essence has a sticky feeling.
In the invention, the humectant comprises one or a combination of more than two of dipropylene glycol, butanediol, pentanediol, glycerol, panthenol, glycerol polyacrylate, glyceryl polyether-26, sodium hyaluronate, hydrolyzed sodium hyaluronate, betaine and trehalose. The sodium hyaluronate has larger molecular weight, can form a moisturizing film on the surface of skin and plays a role in moisturizing. Wherein, the hydrolyzed sodium hyaluronate has smaller molecular weight and can penetrate into the skin deeply, thereby having the functions of repairing and delaying aging. Specifically, in the present invention, the molecular weight of sodium hyaluronate is 100-; the molecular weight of the hydrolyzed sodium hyaluronate is less than 10000 daltons, preferably 5000-.
In some more specific embodiments, the moisturizer comprises one or a combination of two or more of butylene glycol, pentylene glycol, glyceryl polyether-26, sodium hyaluronate, hydrolyzed sodium hyaluronate, preferably butylene glycol, pentylene glycol, glyceryl polyether-26, sodium hyaluronate, and hydrolyzed sodium hyaluronate. Specifically, the addition amount of the butanediol is 1-5%, preferably 2-4%; the addition amount of the pentanediol is 1-4%, and preferably 2-3%; the addition amount of the sodium hyaluronate is 0.001-0.2%, preferably 0.01-0.2%; the addition amount of the glycerol polyether-26 is 1-5%, preferably 2-4%; the addition amount of the hydrolyzed sodium hyaluronate is 0.01-0.2%, preferably 0.05-0.2%.
In order to further improve the efficacy of the tightening essence, the tightening essence further comprises the skin conditioner. The effective components in the skin conditioner can penetrate into the deep part of skin and be absorbed by skin, thereby improving the state of skin.
The addition amount of the skin conditioner is 0.05-0.12%, preferably 0.08-0.1% by taking the total mass of the tightening essence as 100%. Further, the skin conditioning agent may be added in an amount of 0.06%, 0.07%, 0.09%, 0.11%, etc. When the addition amount of the skin conditioner is less than 0.05%, the corresponding effect cannot be achieved; when the skin conditioner is added in an amount of more than 0.12%, the cost is too high.
Specifically, the skin conditioner of the present invention may include one or a combination of two or more of ceramide 2, colloidal oat flour, acetyl hexapeptide-8, palmitoyl oligopeptide, kelp extract, allantoin, pansy extract, and the like. Preferably, allantoin is used as a skin conditioning agent in the present invention.
The addition amount of the thickening agent is 0.01-0.5%, preferably 0.02-0.4% based on the total mass of the tightening essence liquid as 100%. By adding the thickening agent, the firming essence disclosed by the invention can be made to have proper consistency and excellent stability. Preferably, the thickener of the present invention may be added in an amount of 0.05 to 0.3%, 0.1 to 0.25%, 0.12 to 0.2%, or the like.
Specifically, in the present invention, the thickener includes one or a combination of two or more of xanthan gum, polyacrylamide, sodium polyacrylate, carbomer, polyethylene glycol-90M, ammonium acryloyldimethyl taurate/VP copolymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and xanthan gum and sodium polyacrylate are preferably used as the thickener. Further, when xanthan gum or sodium polyacrylate is used as the thickener, the amount of xanthan gum is 0.01 to 0.2%, preferably 0.02 to 0.2%; the amount of sodium polyacrylate added is 0.02-0.15%, preferably 0.04-0.12%.
The addition amount of the chelating agent is 0.01-0.05%, preferably 0.02-0.04%, based on the total mass of the tightening essence as 100%. Specifically, in the present invention, the chelating agent may be disodium EDTA, tetrasodium EDTA, or the like. In addition, the addition amount of the preservative is 0.05-1.2%, preferably 0.05-0.6%, based on 100% of the total mass of the tightening essence. The preservative can comprise one or the combination of more than two of phenoxyethanol, methyl hydroxybenzoate, benzoic acid and salts thereof.
In addition, in order to obtain a firming essence, a solvent is also required to be used therein. The solvent may be the same as or different from the solvent in the first aspect, preferably the same as the solvent in the first aspect, i.e., the components are dissolved using a polar solvent, which may be water or the like.
Further, the second aspect of the present invention also provides a preparation method of the tightening essence according to the second aspect of the present invention, which comprises a step of mixing the components of the tightening essence.
Specifically, the preparation method comprises the following steps:
(1) sequentially adding solvent, chelating agent, skin conditioner, humectant, thickener and part of antiseptic into emulsifying pot, stirring and heating to 80-85 deg.C, stirring to dissolve completely, homogenizing, and sterilizing to obtain phase A;
(2) vacuumizing the phase A, cooling by boiling cooling water, uniformly stirring and homogenizing;
(3) cooling to 42-45 ℃, adding the composition for tightening skin (phase B) prepared in the examples 1-4 and the rest of the preservative (phase C), and uniformly stirring to obtain the tightening essence.
Examples
Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
Examples 1 to 4
The firming skin composition 1-4 is prepared according to the following production process steps and the contents (mass percentages) of the components in the formulation of the firming skin composition of examples 1-4 in the following table 1.
The production process comprises the following steps: the palmitoyl tripeptide-5, alpha-glucan oligosaccharide, inulin, glycerol, 1, 3-propanediol and deionized water are stirred uniformly at room temperature.
TABLE 1
In example 1, the mass ratio of palmitoyl tripeptide-5, alpha-glucan oligosaccharide, inulin, and polyol was 1:22:22:86, and the mass ratio of glycerol to 1, 3-propanediol was about 5.14: 1;
in example 2, the mass ratio of palmitoyl tripeptide-5, alpha-glucan oligosaccharide, inulin, and polyol was about 1:20:20:76.67, and the mass ratio of glycerol to 1, 3-propanediol was 4.75: 1;
in example 3, the mass ratio of palmitoyl tripeptide-5, alpha-glucan oligosaccharide, inulin, and polyol was 1:15:15:50, and the mass ratio of glycerol and 1, 3-propanediol was 4: 1;
in example 4, the mass ratio of palmitoyl tripeptide-5, alpha-glucan oligosaccharide, inulin and polyol is about 1:14.55:13.64:45.45, and the mass ratio of glycerol and 1, 3-propanediol is 4:1, wherein the slightly higher amount of palmitoyl tripeptide-5 and alpha-glucan oligosaccharide causes the firming skin composition 4 of example 4 to be slightly cloudy and also slightly sticky.
Application examples 1 to 4
The tightening essence 1-4 is prepared according to the following production process steps and the contents (mass percentages) of the components in the formula of the tightening essence of application examples 1-4 in the following table 2.
The preparation method of the tightening essence comprises the following steps:
(1) sequentially adding deionized water, chelating agent (EDTA disodium), skin conditioner (allantoin), humectant (pentanediol, sodium hyaluronate, glyceryl polyether-26, hydrolyzed sodium hyaluronate and butanediol), thickener (xanthan gum and sodium polyacrylate) and antiseptic (methyl hydroxybenzoate) into an emulsifying pot, stirring and heating at 80-85 deg.C, stirring uniformly until completely dissolved, homogenizing, and sterilizing to obtain phase A;
(2) vacuumizing the phase A, cooling by boiling cooling water, uniformly stirring and homogenizing;
(3) cooling to 42-45 deg.C, adding the composition for tightening skin (phase B) and antiseptic (phenoxyethanol) (phase C) prepared in examples 1-4, and stirring to obtain tightening essence 1-4.
Wherein, the molecular weight of the sodium hyaluronate is 130-.
TABLE 2
Firming skin effect test
The tightening essence 1-4 in the application examples 1-4 was subjected to effect testing, and screened by dermatologists, 30 subjects were selected and divided into two groups of 15 individuals each, one group used tightening essence 1 and tightening essence 2, the other group used tightening essence 3 and tightening essence 4, and finally, the 30 subjects completed the whole test.
The maximum age of the subject is 50 years, the minimum age is 30 years, and the application part: face (1 2cm by 2cm area selected on each cheek, fixed area using corresponding productSmearing corresponding essence 0.5 g); frequency of use: the composition is administered 1 time per day at night for 4 weeks. On day 0 (before use D0) and on day 28 (after use D28)
The skin thickness and the intensity of the dermis are obtained by measuring the skin with the ultrasonic probe, and the average value is obtained.
The main component of the dermis is collagen, the skin thickness and the dermis strength can reflect the content of the collagen, and the higher the numerical value is, the higher the content of the collagen is.
1. Skin thickness analysis
The results of the skin thickness measurements after using the test product are compared to the baseline value (D0), and the values for the skin thickness at D28 are shown in table 3 below:
TABLE 3
| Skin thickness (mum) | Tightening essence 1 | Tightening essence 2 | Tightening essence 3 | Tightening essence 4 |
| D0 | 1013.90 | 1013.90 | 1013.83 | 1013.83 |
| D28 | 1190.10 | 1231.11 | 1231.52 | 1230.98 |
As can be seen from table 3 above, the firming essence of the present invention can increase the skin thickness, and the calculation using the firming essence 3 as an example shows that D28 is increased by 21.47% compared with D0.
2. Intensity analysis of dermis
The results of the dermal layer strength measurements after application of the test product are compared to a baseline value (D0), and the skin thickness at D28 is shown in Table 4:
TABLE 4
| Strength of dermis | Tightening essence 1 | Tightening essence 2 | Tightening essence 3 | Tightening essence 4 |
| D0 | 39.91 | 39.91 | 39.89 | 39.89 |
| D28 | 40.65 | 42.27 | 42.69 | 42.23 |
As can be seen from the above table, the intensity of the dermis layer of the tightening essence can be increased, and the D28 is increased by 7.02% compared with D0, which is calculated by taking the tightening essence 3 as an example.
As can be seen from the above two tests, the tightening essence of the present invention can increase collagen of the skin and increase the tightness of the skin after being used. In addition, the effects of the tightening essence 2-4 are close to each other, wherein the tightening essence 3 has the best effect, collagen of the skin can be increased after the tightening essence is used, the tightness of the skin is increased, and the tightening essence 4 is slightly poor in texture and slightly turbid.
The above examples of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. A firming skin composition is characterized by comprising the following components in percentage by mass based on 100% of the total mass of the firming skin composition:
palmitoyl tripeptide-5: 0.1-1.5%, preferably 0.3-1%;
α -glucan oligosaccharide: 5-20%, preferably 8-15%;
inulin: 5-15%, preferably 8-15%;
polyol: 40-60%, preferably 40-53%;
solvent: 9 to 39.9%, preferably 16 to 36.7%.
2. The tightening skin composition according to claim 1, wherein the mass ratio of the palmitoyl tripeptide-5, the alpha-glucan oligosaccharide, the inulin, and the polyol is from 1:10 to 30:40 to 90.
3. The tightening skin composition of claims 1 or 2, wherein the polyols comprise glycerin and 1, 3-propanediol; wherein, the addition amount of the glycerin is 35-45%, preferably 35-43% based on the total mass of the firming skin composition as 100%; the 1, 3-propanediol is added in an amount of 5-15%, preferably 5-10%.
4. The tightening skin composition according to claim 3, wherein the mass ratio of glycerin to 1, 3-propanediol is 3 to 6: 1.
5. A method of preparing the tightening skin composition of any one of claims 1-4, comprising the step of mixing the components of the tightening skin composition.
6. Use of the firming skin composition according to any one of claims 1 to 4 in a skin care product, preferably the skin care product comprises a lotion, cream, emulsion, gel or serum.
7. Tightening essence comprising the tightening skin composition according to any one of claims 1 to 4; preferably, the firming skin composition is added in an amount of 0.1 to 5%, preferably 1 to 3%, based on 100% by weight of the total firming essence.
8. The tightening essence of claim 7, further comprising one or a combination of two or more of a moisturizer, a skin conditioner, a thickener, a chelating agent, and a preservative.
9. The tightening essence of claim 8, wherein the moisturizer is added in an amount of 3.011 to 14.4%, preferably 6.1 to 11.4%, based on 100% of the total weight of the tightening essence; the addition amount of the skin conditioner is 0.05-0.12%, preferably 0.08-0.1%; the addition amount of the thickening agent is 0.01-0.2%, preferably 0.05-0.2%; the addition amount of the chelating agent is 0.01-0.05%, preferably 0.02-0.04%; the addition amount of the preservative is 0.05-1.2%, preferably 0.05-0.6%.
10. A method for preparing the tightening essence according to any one of claims 7 to 9, comprising a step of mixing the components of the tightening essence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010966545.3A CN111991263A (en) | 2020-09-15 | 2020-09-15 | Composition for tightening skin and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010966545.3A CN111991263A (en) | 2020-09-15 | 2020-09-15 | Composition for tightening skin and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111991263A true CN111991263A (en) | 2020-11-27 |
Family
ID=73468573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010966545.3A Pending CN111991263A (en) | 2020-09-15 | 2020-09-15 | Composition for tightening skin and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111991263A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412026A (en) * | 2017-08-09 | 2017-12-01 | 广州丸美生物科技有限公司 | Eye essence and its preparation method and application |
| CN109464342A (en) * | 2018-12-29 | 2019-03-15 | 广州市盛美化妆品有限公司 | A kind of anti-aging Essence and preparation method thereof |
| CN109674734A (en) * | 2019-01-22 | 2019-04-26 | 郑娇娇 | It is a kind of with moisturizing, maintenance, releive, the composition of Antiageing effect and its application |
| CN111388403A (en) * | 2020-04-12 | 2020-07-10 | 广州市索柔生物科技有限公司 | Prebiotic composition and application thereof |
-
2020
- 2020-09-15 CN CN202010966545.3A patent/CN111991263A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412026A (en) * | 2017-08-09 | 2017-12-01 | 广州丸美生物科技有限公司 | Eye essence and its preparation method and application |
| CN109464342A (en) * | 2018-12-29 | 2019-03-15 | 广州市盛美化妆品有限公司 | A kind of anti-aging Essence and preparation method thereof |
| CN109674734A (en) * | 2019-01-22 | 2019-04-26 | 郑娇娇 | It is a kind of with moisturizing, maintenance, releive, the composition of Antiageing effect and its application |
| CN111388403A (en) * | 2020-04-12 | 2020-07-10 | 广州市索柔生物科技有限公司 | Prebiotic composition and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 广州瑞莉化妆品有限公司: "迪凯瑞 烟酰胺透亮焕颜安瓶精华液（日用）", 《国产非特殊用途化妆品备案平台，网址：HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20190620171858ASPXK&NID=20190620171858ASPXK 》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2021003962A1 (en) | Skincare composition for repairing skin, and preparation method therefor | |
| CN109464378B (en) | Multi-effect repair eye cream and preparation method thereof | |
| CN108338965B (en) | Coarse grain composition and preparation method thereof | |
| CN111603433B (en) | Mild washing and protecting article for infants and preparation method thereof | |
| CN113304075B (en) | Glacier rock cleaning oil control mud film and preparation method thereof | |
| CN111557886B (en) | Plant-nourishing efficient moisturizing cream and preparation method thereof | |
| CN111374924A (en) | Baby wheat fresh extract raw pulp hip-protecting cream and preparation method thereof | |
| CN109350579B (en) | Whitening cosmetic additive, whitening skin-refreshing lotion and preparation method thereof | |
| CN113116755A (en) | Skin care composition for promoting penetration and preparation method and application thereof | |
| CN114224779A (en) | Eye repair composition and application thereof | |
| CN112891286A (en) | Beautifying and firming repair cream and preparation method thereof | |
| CN116172891A (en) | Multi-effect moisturizing composition and preparation method thereof | |
| CN112773761B (en) | Cosmetic composition, essence and preparation method thereof | |
| CN108852976B (en) | Crystal moistening nourishing lotion | |
| CN113181074B (en) | Compound folic acid anti-allergic and anti-irritation skin care composition as well as preparation method and application thereof | |
| CN107837223B (en) | Facial mask essence containing dendrobium officinale extract, facial mask containing dendrobium officinale extract, preparation method of facial mask essence and application of facial mask essence | |
| CN111773174B (en) | Repairing cream and preparation method thereof | |
| JP3435181B2 (en) | External preparation for melanin production suppression | |
| CN112656731A (en) | Composition with red-repairing effect and preparation method and application thereof | |
| CN109453088B (en) | Whitening and firming cream, preparation method thereof and tyrosinase inhibitor | |
| CN111012699A (en) | Antioxidant oil-controlling emulsion containing fucoidan-kelp extract | |
| CN114159333B (en) | Myobase liquid and preparation method thereof | |
| CN113633599B (en) | Skin foundation essence containing dendrobium officinale extract and preparation method thereof | |
| CN114288201B (en) | Composition for removing pouch and fading black eye, and preparation method and application thereof | |
| CN116035987A (en) | Small molecule peptide multielement composition and skin care product containing same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201127 |
|
| RJ01 | Rejection of invention patent application after publication |