CN116370349A - Amino acid facial cleanser, and preparation method and application thereof - Google Patents
Amino acid facial cleanser, and preparation method and application thereof Download PDFInfo
- Publication number
- CN116370349A CN116370349A CN202310404802.8A CN202310404802A CN116370349A CN 116370349 A CN116370349 A CN 116370349A CN 202310404802 A CN202310404802 A CN 202310404802A CN 116370349 A CN116370349 A CN 116370349A
- Authority
- CN
- China
- Prior art keywords
- amino acid
- parts
- facial cleanser
- hydroxypropyl starch
- humectant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001815 facial effect Effects 0.000 title claims abstract description 58
- 150000001413 amino acids Chemical class 0.000 title claims abstract description 57
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 239000003906 humectant Substances 0.000 claims abstract description 42
- 239000002562 thickening agent Substances 0.000 claims abstract description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000004094 surface-active agent Substances 0.000 claims abstract description 22
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 12
- 239000002738 chelating agent Substances 0.000 claims abstract description 12
- 239000002826 coolant Substances 0.000 claims abstract description 12
- 239000000945 filler Substances 0.000 claims abstract description 12
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 11
- 125000003118 aryl group Chemical group 0.000 claims abstract description 11
- 239000008367 deionised water Substances 0.000 claims abstract description 9
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 6
- 230000003750 conditioning effect Effects 0.000 claims abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 67
- 239000001341 hydroxy propyl starch Substances 0.000 claims description 54
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims description 54
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 38
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 38
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 37
- 239000000203 mixture Substances 0.000 claims description 31
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 29
- 229920002498 Beta-glucan Polymers 0.000 claims description 29
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 29
- 229920001577 copolymer Polymers 0.000 claims description 29
- 235000011187 glycerol Nutrition 0.000 claims description 29
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 28
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 28
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 27
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 27
- 150000002148 esters Chemical class 0.000 claims description 27
- 229910019142 PO4 Inorganic materials 0.000 claims description 26
- 239000010452 phosphate Substances 0.000 claims description 26
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 26
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 claims description 24
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 8
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 8
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 6
- 239000004310 lactic acid Substances 0.000 claims description 6
- 235000014655 lactic acid Nutrition 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229940079988 potassium cocoyl glycinate Drugs 0.000 claims description 5
- 229940045944 sodium lauroyl glutamate Drugs 0.000 claims description 5
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 5
- DDGPBVIAYDDWDH-UHFFFAOYSA-N 3-[dodecyl(dimethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC(O)CS([O-])(=O)=O DDGPBVIAYDDWDH-UHFFFAOYSA-N 0.000 claims description 4
- 239000005995 Aluminium silicate Substances 0.000 claims description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 4
- 235000012211 aluminium silicate Nutrition 0.000 claims description 4
- 229960003237 betaine Drugs 0.000 claims description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 4
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 4
- 229960004889 salicylic acid Drugs 0.000 claims description 4
- 229940079776 sodium cocoyl isethionate Drugs 0.000 claims description 4
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 claims description 4
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
- ZTOKUMPYMPKCFX-CZNUEWPDSA-N (E)-17-[(2R,3R,4S,5S,6R)-6-(acetyloxymethyl)-3-[(2S,3R,4S,5S,6R)-6-(acetyloxymethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxyoctadec-9-enoic acid Chemical compound OC(=O)CCCCCCC/C=C/CCCCCCC(C)O[C@@H]1O[C@H](COC(C)=O)[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(C)=O)O1 ZTOKUMPYMPKCFX-CZNUEWPDSA-N 0.000 claims description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- KTYVHLCLTPLSGC-UHFFFAOYSA-N amino propanoate Chemical compound CCC(=O)ON KTYVHLCLTPLSGC-UHFFFAOYSA-N 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 229940041616 menthol Drugs 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 235000021317 phosphate Nutrition 0.000 claims description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 2
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 claims description 2
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 229940083982 sodium phytate Drugs 0.000 claims description 2
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims 2
- 239000006260 foam Substances 0.000 abstract description 32
- 230000000694 effects Effects 0.000 abstract description 10
- 230000000087 stabilizing effect Effects 0.000 abstract description 7
- 239000007788 liquid Substances 0.000 abstract description 5
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 230000000052 comparative effect Effects 0.000 description 31
- 238000012360 testing method Methods 0.000 description 21
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 16
- 229920002674 hyaluronan Polymers 0.000 description 16
- 229960003160 hyaluronic acid Drugs 0.000 description 16
- 239000000243 solution Substances 0.000 description 10
- 238000004140 cleaning Methods 0.000 description 6
- 210000001061 forehead Anatomy 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 238000005238 degreasing Methods 0.000 description 3
- 238000005187 foaming Methods 0.000 description 3
- 239000004519 grease Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- -1 palmitoyl amino acid Chemical class 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 108010020346 Polyglutamic Acid Proteins 0.000 description 2
- 239000004373 Pullulan Substances 0.000 description 2
- 229920001218 Pullulan Polymers 0.000 description 2
- 241000221035 Santalaceae Species 0.000 description 2
- 235000008632 Santalum album Nutrition 0.000 description 2
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 235000019423 pullulan Nutrition 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 229940031723 1,2-octanediol Drugs 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 1
- 229940079779 disodium cocoyl glutamate Drugs 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000008258 liquid foam Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229940079781 sodium cocoyl glutamate Drugs 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The application discloses an amino acid facial cleanser and a preparation method and application thereof, and relates to the technical field of cosmetics. The application provides an amino acid facial cleanser, which comprises the following components in parts by weight: 20-40 parts of surfactant, 8-15 parts of humectant, 5-15 parts of thickener, 0.1-1 part of antioxidant, 0.1-1 part of pH regulator, 0.1-1 part of skin conditioner, 0.1-0.8 part of aromatic, 0.4-1.5 parts of filler, 0.01-0.1 part of chelating agent, 0.01-0.1 part of cooling agent and the balance of deionized water. The application provides an amino acid facial cleanser, which can maintain the stability of a microcosmic foam wall and reduce the flow speed of liquid in the foam wall by selecting components of a specific humectant and a thickening agent on the premise of using components of a specific amino acid surfactant, a skin conditioning agent and the like, so as to achieve the effect of stabilizing the foam.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to an amino acid facial cleanser and a preparation method and application thereof.
Background
Facial cleanser belongs to facial cleansing products, and is used for cleaning sebum, sweat, flaked horny layer, blocked pores, cosmetic residues and the like secreted by human facial skin during cleaning. These residual metabolites can react with oxygen in the air, deposited molecules, and upon exposure to sunlight or the presence of bacteria on the skin, various physicochemical or biochemical reactions can occur, forming irritating substances that can harm the skin. In order to achieve the effects of high-efficiency cleaning, degreasing and blackhead removal, the traditional facial cleanser is added with soap base, SLS (sodium laurylsulfate) or SLES (sodium laurylsulfate) surfactant with strong degreasing and irritation. Because of higher pH and stronger degreasing force, the facial cleanser can achieve good decontamination effect, but is not mild enough to the skin. This process breaks the sebaceous membrane of the skin, making the skin more vulnerable to external stimuli.
Amino acid facial cleanser is a novel facial cleanser which appears in the market in recent years. The amino acid facial cleanser adopts amino acid surfactant. The weak acidic amino acids are active, and the pH value is close to that of human skin, so that the skin is warm and friendly. Common amino acid surfactants include: sodium cocoyl glutamate, disodium cocoyl glutamate, sodium lauroyl glutamate, potassium cocoyl glycinate, and the like. In addition, a humectant is added into the amino acid facial cleanser to clean skin and moisten skin at the same time, so that the water-oil balance of the skin is maintained.
Although the amino acid facial cleanser has a plurality of advantages, the amino acid facial cleanser still has a plurality of defects in the technical aspect, and the effect of the product is easily reduced. Foam enhances the contact area of the surfactant with the skin, indirectly enhances the soil removal, and the amino acid itself does not exhibit good foaming properties. The existing amino acid facial cleanser only adopts cocoyl/lauroyl/palmitoyl amino acid with foaming capacity to achieve the effect of cleaning and decontaminating, so that the problems of general foaming and foam stabilizing capacity and weaker oil control cleaning effect exist, and the use experience brought by people is poor. One solution to this problem is to raise the concentration of the amino acid, which, however, can greatly increase the cost of the formulation and limit mass production.
Disclosure of Invention
Based on the above, the purpose of the present application is to overcome the shortcomings of the prior art and provide an amino acid facial cleanser and a preparation method and application thereof.
In order to achieve the above purpose, the technical scheme adopted by the application is as follows: an amino acid facial cleanser comprises the following components in parts by weight, based on 100 parts by weight: 20-40 parts of surfactant, 8-15 parts of humectant, 5-15 parts of thickener, 0.1-1 part of antioxidant, 0.1-1 part of pH regulator, 0.1-1 part of skin conditioner, 0.1-0.8 part of aromatic, 0.4-1.5 parts of filler, 0.01-0.1 part of chelating agent, 0.01-0.1 part of cooling agent and the balance of deionized water; wherein the surfactant is at least one of potassium cocoyl glycinate, sodium cocoyl aminopropionate, lauryl hydroxysulfobetaine, sodium cocoyl isethionate, sodium lauroyl glutamate and sodium methyl cocoyl taurate; the humectant is a mixture of glycerin, methyl propylene glycol, 1, 2-hexanediol, sodium hyaluronate, octanediol and beta-glucan, and the thickener is a mixture of water, acrylic acid (ester) copolymer, hydroxypropyl starch and hydroxypropyl starch phosphate.
The application provides an amino acid facial cleanser, which can maintain the stability of a microcosmic foam wall and reduce the flow speed of liquid in the foam wall by selecting the components of a specific humectant and a thickening agent on the premise of using the components such as the amino acid surfactant, the skin conditioning agent and the like, so as to achieve the effect of stabilizing the foam.
Preferably, the amino acid facial cleanser comprises the following components in parts by weight based on 100 parts by weight: 25-35 parts of surfactant, 10-13 parts of humectant, 8-10 parts of thickener, 0.3-0.7 part of antioxidant, 0.1-0.3 part of pH regulator, 0.3-0.6 part of skin conditioner, 0.1-0.2 part of aromatic, 0.6-1 part of filler, 0.03-0.08 part of chelating agent, 0.03-0.08 part of cooling agent and the balance of deionized water.
The inventor finds that when the weight parts of each component in the amino acid facial cleanser adopt the selection, the prepared amino acid facial cleanser has better foam initial height and foam stability.
Preferably, the humectant comprises 45-65% of glycerin, 20-45% of methyl propylene glycol, 3-10% of 1, 2-hexanediol, 3-10% of sodium hyaluronate, 0.1-1% of octanediol and 0.0001-0.003% of ultra-pure beta-glucan. Preferably, the thickener consists of the following components in percentage by mass, the balance of water, 15-30% of acrylic acid (ester) copolymer, 10-25% of hydroxypropyl starch phosphate and 1-5% of hydroxypropyl starch
The inventor finds that when the components of the humectant and the thickener in the amino acid facial cleanser are selected in a specific proportion, the prepared amino acid facial cleanser has better foam initial height and foam stability.
Preferably, the humectant comprises, by mass, 50% -60% of glycerin, 25% -35% of methyl propylene glycol, 5% -8% of 1, 2-hexanediol, 5% -8% of sodium hyaluronate, 0.6% -0.9% of octanediol, and 0.0005% -0.0025% of ultrapure beta-glucan; the thickener consists of the following components in percentage by mass, the balance of water, 22-28% of acrylic acid (ester) copolymer, 17-23% of hydroxypropyl starch phosphate and 2-4% of hydroxypropyl starch.
Preferably, the humectant consists of 53 mass percent of glycerin, 33 mass percent of methyl propylene glycol, 6.6 mass percent of 1, 2-hexanediol, 6.6 mass percent of sodium hyaluronate, 0.798 mass percent of octanediol and 0.002 mass percent of ultra-pure beta-glucan; the thickener consists of the following components in percentage by mass, the balance of water, 25% of acrylic acid (ester) copolymer, 20% of hydroxypropyl starch phosphate and 3% of hydroxypropyl starch.
The inventor finds that when the components of the humectant and the thickener in the amino acid facial cleanser are selected in the specific proportion, the initial height of the prepared amino acid facial cleanser foam and the stability of the foam are optimal.
Preferably, the sodium hyaluronate is high affinity sodium hyaluronate.
Described in the applicationThe high affinity sodium hyaluronate is CationHA TM Clear 1, purchased from Hua Xi organism. The inventors of the present application have found through a great deal of research that the molecular weight of hyaluronic acid used is limited to 110-150 ten thousand, and the hyaluronic acid has good performance of reducing the flow of liquid in the membrane. In addition, in order to improve the affinity of the product and the foam gain while reducing the irritation of the surfactant, a lower molecular weight hyaluronic acid is also required. For this purpose, the present application specifically selects sodium hyaluronate with high affinity complexed with hyaluronic acid of different molecular weights (Hua Xi organism, cationHA) TM Clear 1) is obtained by fully complexing two kinds of Hyaluronic Acid (HA) with different molecular weights by adopting a cationic polymer, wherein one kind of hyaluronic acid is medium molecular HA (130 ten thousand molecular weight), and the other kind of hyaluronic acid is oligomeric small molecular HA (1 ten thousand molecular weight) obtained by adopting an enzyme digestion process, and the ratio of hyaluronic acid to HA is about 1:7. Compared with sodium hyaluronate which is added independently, the oligomeric small molecule sodium hyaluronate which is unique in the high-affinity sodium hyaluronate is more convenient for percutaneous absorption. The hyaluronic acid can be more easily resided in the flushing process, shows higher affinity, and provides better residency conditions for the exertion of the hyaluronic acid when the hyaluronic acid is applied to the facial cleanser; in addition, the small molecular weight hyaluronic acid has more remarkable effect of reducing the irritation caused by the surfactant.
Preferably, the amino acid facial cleanser comprises at least one of the following (a) - (g):
(a) The antioxidant is at least one of p-hydroxyacetophenone, phenoxyethanol and alkyl dihydric alcohol;
(b) The pH regulator is at least one of citric acid and lactic acid;
(c) The skin conditioner is at least one of betaine salicylic acid, sophorolipid, lignum Santali albi extract, carbon powder, lactic acid and azelaic acid;
(d) The aromatic is daily essence;
(e) The filler is at least one of sodium polyacrylate and kaolin;
(f) The chelating agent is at least one of EDTA disodium, octanoyl hydroxamic acid and sodium phytate;
(g) The cooling agent is at least one of menthol and menthyl lactate.
In addition, the application provides a preparation method of the amino acid facial cleanser, which comprises the following steps:
(1) Mixing the surfactant, acrylic acid (ester) copolymer in the thickener, hydroxypropyl starch phosphate and hydroxypropyl starch, glycerin in the humectant, methyl propylene glycol and deionized water, and fully stirring at 65-80 ℃ at 20-35rpm;
(2) Cooling the mixture obtained in the step (1) to room temperature, adding the skin conditioning agent, the cooling agent, the aromatic, the pH regulator, the antioxidant, the chelating agent, the filler and the 1, 2-hexanediol in the humectant, the sodium hyaluronate, the octanediol and the beta-glucan into a main material pot, keeping the stirring speed at 25-40rpm, and uniformly stirring to obtain the amino acid oil-control facial cleanser.
Compared with the prior art, the beneficial effects of this application are: the application provides an amino acid facial cleanser, which can maintain the stability of a microcosmic foam wall and reduce the flow speed of liquid in the foam wall by selecting the components of a specific humectant and a thickening agent on the premise of using the components such as the amino acid surfactant, the skin conditioning agent and the like, so as to achieve the effect of stabilizing the foam.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present application, the present application will be further described with reference to specific examples. In the examples, the experimental methods used are conventional methods unless otherwise specified, and the materials, reagents, etc. used, unless otherwise specified, are commercially available.
In the following examples and comparative examples, the sodium hyaluronate was sodium hyaluronate with high affinity, and sodium hyaluronate with high affinity was CationHA TM Clear 1, purchased from Hua Xi organism;
beta-glucan is ultrapure beta-glucan with purity >95%, hydrasensyl Glucan Green, purchased from basf.
Examples and comparative examples
Examples 1 to 5
The application provides an amino acid facial cleanser, wherein the total weight of the amino acid facial cleanser is 100 parts, and the components and the weight parts of the components in examples 1-5 are shown in table 1;
the antioxidants, pH regulators, skin conditioners, fragrances, fillers, chelating agents and coolants used in examples 1-5 of the present application were the same in composition, in particular the antioxidant was p-hydroxyacetophenone; the pH regulator is citric acid; the skin conditioner is a mixture of betaine salicylic acid, sophorolipid, sandalwood extract, carbon powder, lactic acid and azelaic acid, and the weight ratio of the betaine salicylic acid is as follows: sophorolipids: sandalwood extract: carbon powder: lactic acid: azelaic acid = 1:1:1:0.5:0.001:0.0005; the aromatic is daily essence; the filler is a mixture of sodium polyacrylate and kaolin, and the weight ratio of the sodium polyacrylate is as follows: kaolin = 7:1; the chelating agent is disodium EDTA; the cooling agent is menthol.
The components and proportions of the surfactant, the humectant and the thickener in examples 1 to 5 of the application are selected as follows:
the surfactant is a mixture of potassium cocoyl glycinate, sodium cocoyl aminopropionate, lauryl hydroxysulfobetaine, sodium cocoyl isethionate, sodium lauroyl glutamate and sodium methyl cocoyl taurate, and the weight ratio of the surfactant to the mixture is potassium cocoyl glycinate: 38%, sodium cocoamidopropionate: 27.5%, lauryl hydroxysulfobetaine: 17%, sodium cocoyl isethionate: 10%, sodium lauroyl glutamate: 4%, sodium methyl cocoyl taurate: 3.5%.
The thickener is a mixture of water, acrylic acid (ester) copolymer, hydroxypropyl starch and hydroxypropyl starch phosphate, and consists of the following components in percentage by mass: water balance, 25% of acrylic acid (ester) copolymer, 20% of hydroxypropyl starch phosphate and 3% of hydroxypropyl starch;
the humectant is a mixture of glycerin, methyl propylene glycol, 1, 2-hexanediol, high-affinity sodium hyaluronate, octanediol and beta-glucan, and consists of the following components in percentage by mass: 53% of glycerol, 33% of methyl propylene glycol, 6.6% of 1, 2-hexanediol, 6.6% of high-affinity sodium hyaluronate, 0.798% of octanediol and 0.002% of ultrapure beta-glucan;
the preparation method of the amino acid facial cleanser comprises the following steps:
(1) Mixing the surfactant, acrylic acid (ester) copolymer in the thickener, hydroxypropyl starch phosphate and hydroxypropyl starch, glycerin in the humectant, methyl propylene glycol and deionized water, and fully stirring at 65-80 ℃ at 20-35rpm;
(2) Cooling the mixture obtained in the step (1) to room temperature, adding the skin conditioning agent, the cooling agent, the aromatic, the pH regulator, the antioxidant, the chelating agent, the filler and the 1, 2-hexanediol in the humectant, the sodium hyaluronate, the octanediol and the beta-glucan into a main material pot, keeping the stirring speed at 25-40rpm, and uniformly stirring to obtain the amino acid oil-control facial cleanser.
TABLE 1
Examples 6 to 9
The application provides an amino acid facial cleanser, which comprises 100 parts by weight of the total amino acid facial cleanser, and examples 6-9 are different from example 1 in the selection of only the thickener, and the other components and parts by weight are the same, wherein the selection of the thickener in examples 6-9 is as follows.
Example 6
The thickener described in example 6 is a mixture of water, acrylic acid (ester) copolymer, hydroxypropyl starch and hydroxypropyl starch phosphate, and consists of the following components in percentage by mass, the balance of water, acrylic acid (ester) copolymer 22%, hydroxypropyl starch phosphate 23% and hydroxypropyl starch 4%.
Example 7
The thickener described in example 7 is a mixture of water, acrylic acid (ester) copolymer, hydroxypropyl starch and hydroxypropyl starch phosphate, and consists of the following components in percentage by mass, the balance of water, 28% of acrylic acid (ester) copolymer, 17% of hydroxypropyl starch phosphate and 2% of hydroxypropyl starch.
Example 8
The thickener described in example 8 is a mixture of water, acrylic acid (ester) copolymer, hydroxypropyl starch and hydroxypropyl starch phosphate, and consists of the following components in percentage by mass, the balance of water, 15% of acrylic acid (ester) copolymer, 25% of hydroxypropyl starch phosphate and 5% of hydroxypropyl starch.
Example 9
The thickener described in example 9 is a mixture of water, acrylic acid (ester) copolymer, hydroxypropyl starch and hydroxypropyl starch phosphate, and consists of the following components in percentage by mass, the balance of water, 30% of acrylic acid (ester) copolymer, 10% of hydroxypropyl starch phosphate and 1% of hydroxypropyl starch.
Examples 10 to 13
The application provides an amino acid facial cleanser, which comprises 100 parts by weight of the total amino acid facial cleanser, and examples 10-13 are different from example 1 in the selection of only the humectant, and the other components and parts by weight are the same, wherein the selection of the humectant in examples 10-13 is as follows.
Example 10
The humectant in the embodiment 10 is a mixture of glycerin, methyl propylene glycol, 1, 2-hexanediol, high-affinity sodium hyaluronate, octanediol and beta-glucan, and consists of the following components in percentage by mass: 51.3995% of glycerol, 35% of methyl propylene glycol, 8% of 1, 2-hexanediol, 5% of high-affinity sodium hyaluronate, 0.6% of octanediol and 0.0005% of ultrapure beta-glucan.
Example 11
The humectant in the example 11 is a mixture of glycerin, methyl propylene glycol, 1, 2-hexanediol, high-affinity sodium hyaluronate, octanediol and beta-glucan, and consists of the following components in percentage by mass: 59.0975% of glycerol, 27% of methyl propylene glycol, 5% of 1, 2-hexanediol, 8% of high-affinity sodium hyaluronate, 0.9% of octanediol and 0.0025% of ultrapure beta-glucan.
Example 12
The humectant in example 12 is a mixture of glycerin, methyl propylene glycol, 1, 2-hexanediol, high-affinity sodium hyaluronate, octanediol and beta-glucan, and consists of the following components in percentage by mass: 45.8999% of glycerol, 41% of methyl propylene glycol, 10% of 1, 2-hexanediol, 3% of high-affinity sodium hyaluronate, 0.1% of octanediol and 0.0001% of ultra-pure beta-glucan.
Example 13
The humectant in the embodiment 13 is a mixture of glycerin, methyl propylene glycol, 1, 2-hexanediol, high-affinity sodium hyaluronate, octanediol and beta-glucan, and consists of the following components in percentage by mass: 64.97% of glycerol, 21% of methyl propylene glycol, 3% of 1, 2-hexanediol, 10% of high-affinity sodium hyaluronate, 1% of octanediol and 0.003% of ultra-pure beta-glucan.
Comparative examples 1 to 8
The present comparative example provides an amino acid facial cleanser, wherein the total weight of the amino acid facial cleanser is 100 parts, the comparative examples 1 to 4 are different from the example 1 in the selection of only the thickener, and the other components and the weight of the thickener are identical, and the selection of the thickener of the comparative examples 1 to 4 is as follows. Comparative examples 5-8 the humectant was selected differently from example 1 only, and the remaining components and parts by weight were all the same, the humectants of comparative examples 5-8 were selected as follows:
comparative example 1
The thickener described in comparative example 1 is a mixture of water, acrylic acid (ester) copolymer and hydroxypropyl starch phosphate, and consists of the following components in percentage by mass, the balance of water, 28% of acrylic acid (ester) copolymer and 20% of hydroxypropyl starch phosphate.
Comparative example 2
The thickener in comparative example 2 is a mixture of water, acrylic acid (ester) copolymer and hydroxypropyl starch, and consists of the following components in percentage by mass, 52% of water, 45% of acrylic acid (ester) copolymer and 3% of hydroxypropyl starch.
Comparative example 3
The thickener described in comparative example 3 is a mixture of water, PEG/stearyl alcohol/SMDI copolymer, hydroxypropyl starch, and hydroxypropyl starch phosphate, and consists of the following components in percentage by mass, water 52%, PEG/stearyl alcohol/SMDI copolymer 25%, hydroxypropyl starch phosphate 20%, and hydroxypropyl starch 3%.
Comparative example 4
The thickener in comparative example 4 is a mixture of water, acrylic acid (ester) copolymer, hydroxypropyl starch and hydroxypropyl methyl cellulose, and consists of the following components in percentage by mass, 52% of water, 25% of acrylic acid (ester) copolymer, 20% of hydroxypropyl methyl cellulose and 3% of hydroxypropyl starch.
Comparative example 5
The humectant in comparative example 5 is a mixture of glycerin, methyl propylene glycol, high-affinity sodium hyaluronate, octanediol and beta-glucan, and consists of the following components in percentage by mass: 53% of glycerol, 33% of methyl propylene glycol, 13.2% of high-affinity sodium hyaluronate, 0.798% of caprylic glycol and 0.002% of ultrapure beta-glucan.
Comparative example 6
The humectant in comparative example 6 is a mixture of glycerin, methyl propylene glycol, 1, 2-hexanediol, octanediol and beta-glucan, and consists of the following components in percentage by mass: 53% of glycerol, 33% of methyl propylene glycol, 13.2% of 1, 2-hexanediol, 0.798% of octanediol and 0.002% of ultra-pure beta-glucan.
Comparative example 7
The humectant in comparative example 7 is a mixture of glycerin, methyl propylene glycol, 1, 2-hexanediol, pullulan, octylglycol and beta-glucan, and consists of the following components in percentage by mass: 53% of glycerol, 33% of methyl propylene glycol, 6.6% of 1, 2-hexanediol, 6.6% of pullulan, 0.798% of octanediol and 0.002% of ultrapure beta-glucan.
Comparative example 8
The humectant in comparative example 8 is a mixture of glycerin, methyl propylene glycol, 1, 2-hexanediol, high-affinity sodium hyaluronate, octanediol and gamma-sodium polyglutamate, and consists of the following components in percentage by mass: 53% of glycerol, 33% of methyl propylene glycol, 6.6% of 1, 2-hexanediol, 6.6% of high-affinity sodium hyaluronate, 0.798% of octyl glycol and 0.002% of gamma-sodium polyglutamate.
Performance testing
Test example 1 Rogowski foam test
The testing process comprises the following steps: the amino acid facial cleanser prepared in the examples and the comparative examples is subjected to foam test after standing and aging for 24 hours at room temperature, and the test method is determined by using a Roche foam meter according to GB/17173;
test temperature: 45 ℃;
the operation steps are as follows:
the temperature of the thermostatic bath is controlled to be 45+/-0.5 ℃, and then circulating thermostatic water is pumped into an outer sleeve of the instrument through the thermostatic bath, so that the instrument is operated under the thermostatic condition.
2.50g of the sample to be tested was weighed and dissolved completely with 100ml of hard water and 900ml of deionized water.
The inner wall of the scale tube is washed clean by distilled water, and then the tube wall is washed clean by test solution.
And placing the volumetric flask containing the solution to be measured in a constant temperature tank to maintain a certain temperature.
After the constant temperature, slowly adding the solution to be measured to a 50mL scale along the inner wall of the column, and vertically clamping the foam pipette fully sucking the solution to be measured, so that the lower end of the foam pipette is aligned with the scale mark on the column.
The tap of the foam pipette is opened to allow the solution to flow down completely, and when the solution in the drip tube is finished, a stopwatch is started immediately, and the initial foam height is recorded. The foam height was then recorded over 5min,10min and the foam value was expressed as foam height.
The above test was repeated 3 times, and the vessel wall had to be cleaned before each test to avoid affecting the data. The average value of the test was taken as the final result. The parallel measurement allows a difference of not more than 3mm.
Test results: as shown in tables 4 and 5.
TABLE 4 Table 4
TABLE 5
Test example 3 oil control efficacy test
The testing process comprises the following steps: the amino acid facial cleanser prepared in the embodiment and the comparative example is subjected to an oil control efficacy test;
group of subjects: 105 men between 18 and 50 years of age
The grouping method comprises the following steps: 105 subjects were equally divided into 2 groups, each corresponding to 5 persons, and the amino acid facial washes prepared in examples and comparative examples were used, respectively.
Health status: the skin of the subject is healthy, the skin allergy history does not exist, the oil content Sebumeter test value is more than or equal to 120 mug/cm < 2 >, and the volunteer selection standard of the subject is met.
Test instrument:
skin grease tester Sebumeter SM-815 (Courage & Khazaka, germany);
test environment: temperature: 21.0 ℃ +/-1.0 ℃; humidity: 50% ± 10%;
the testing process comprises the following steps:
1. after the face of the subject is cleaned with clear water (the forehead cannot be cleaned), the subject sits still in the constant temperature and humidity room for 30min. The subject was cleaned with an alcohol pad and measured for left and right forehead grease values using a Sebumeter, which would be a short-term basis.
2. After the subjects used the samples for 4 hours, the forehead sample area and the blank area were tested for grease content with a Sebumeter, respectively.
3. The subjects were given 7 days at home, were interviewed on site, were sitting still in a constant temperature and humidity room for 30min, and were thereafter subjected to a Sebumeter (left and right forehead) test.
4. The subjects were allowed to sit still in a constant temperature and humidity room for 30min after 14 days at home with the sample, interview on site, clean water after cleaning the face (no ability to clean the forehead), and then performed a Sebumeter (left and right forehead) test.
Oil content: the sample area and the control area were tested for lipid content (1 time) using a Sebumeter 4 hours, 7 days, 14 days after use, before use.
Parameter interpretation: the smaller the parameter value, the lower the skin fat content.
Test results: as shown in tables 6 and 7.
TABLE 6
TABLE 7
From the experimental data in tables 1 and 2, the stability of the micro foam wall is maintained and the flow speed of liquid in the liquid foam wall is reduced by selecting the components of the specific humectant and the thickener, so that the foam stabilizing effect is achieved, and the oil control effect of the amino acid facial cleanser is improved.
As is clear from the comparison of example 1 and comparative examples 1-2, the hydroxypropyl starch and hydroxypropyl starch phosphate in the thickener of the present invention are a synergistic system, and the two components are not indispensable. As is clear from comparison of example 1 and comparative examples 5 to 6, 1, 2-hexanediol and sodium hyaluronate in the moisturizer are a synergistic system, and the two components are not indispensable. As is evident from comparison of example 1, comparative examples 3-4 and comparative examples 7-8, replacement of a certain component in the thickener or humectant results in a significant decrease in the air bubble and foam stabilizing ability of the resulting amino acid-washed facial milk, indicating that only the thickener or humectant composed of the specific components can enhance the air bubble and foam stabilizing ability of the amino acid-washed facial milk.
Finally, it should be noted that the above embodiments are only for illustrating the technical solutions of the present application and not for limiting the scope of protection of the present application, and although the present application has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made to the technical solutions of the present application without departing from the spirit and scope of the technical solutions of the present application.
Claims (8)
1. The amino acid facial cleanser is characterized by comprising the following components in parts by weight, based on 100 parts by weight: 20-40 parts of surfactant, 8-15 parts of humectant, 5-15 parts of thickener, 0.1-1 part of antioxidant, 0.1-1 part of pH regulator, 0.1-1 part of skin conditioner, 0.1-0.8 part of aromatic, 0.4-1.5 parts of filler, 0.01-0.1 part of chelating agent, 0.01-0.1 part of cooling agent and the balance of deionized water; wherein the surfactant is at least one of potassium cocoyl glycinate, sodium cocoyl aminopropionate, lauryl hydroxysulfobetaine, sodium cocoyl isethionate, sodium lauroyl glutamate and sodium methyl cocoyl taurate; the humectant is a mixture of glycerin, methyl propylene glycol, 1, 2-hexanediol, sodium hyaluronate, octanediol and beta-glucan, and the thickener is a mixture of water, acrylic acid (ester) copolymer, hydroxypropyl starch and hydroxypropyl starch phosphate.
2. The amino acid facial cleanser of claim 1, comprising the following components in parts by weight, per 100 parts by weight: 25-35 parts of surfactant, 10-13 parts of humectant, 8-10 parts of thickener, 0.3-0.7 part of antioxidant, 0.1-0.3 part of pH regulator, 0.3-0.6 part of skin conditioner, 0.1-0.2 part of aromatic, 0.6-1 part of filler, 0.03-0.08 part of chelating agent, 0.03-0.08 part of cooling agent and the balance of deionized water.
3. The amino acid facial cleanser according to claim 1, wherein the humectant comprises the following components, by mass, 45% -65% of glycerin, 20% -45% of methyl propylene glycol, 3% -10% of 1, 2-hexanediol, 3% -10% of sodium hyaluronate, 0.1% -1% of caprylyl glycol and 0.0001% -0.003% of ultra-pure beta-glucan; the thickener consists of the following components in percentage by mass, 15-30% of acrylic acid (ester) copolymer, 10-25% of hydroxypropyl starch phosphate, 1-5% of hydroxypropyl starch and the balance of water.
4. The amino acid facial cleanser according to claim 3, wherein the humectant comprises the following components, by mass, 50% -60% of glycerin, 25% -35% of methyl propylene glycol, 5% -8% of 1, 2-hexanediol, 5% -8% of sodium hyaluronate, 0.6% -0.9% of caprylyl glycol, and 0.0005% -0.0025% of ultra-pure beta-glucan; the thickener consists of the following components in percentage by mass, 22-28% of acrylic acid (ester) copolymer, 17-23% of hydroxypropyl starch phosphate, 2-4% of hydroxypropyl starch and the balance of water.
5. The amino acid facial cleanser according to claim 4, wherein the humectant comprises the following components in percentage by mass, 53% of glycerin, 33% of methyl propylene glycol, 6.6% of 1, 2-hexanediol, 6.6% of sodium hyaluronate, 0.798% of octanediol and 0.002% of ultra-pure beta-glucan; the thickener comprises the following components in percentage by mass, 25% of acrylic acid (ester) copolymer, 20% of hydroxypropyl starch phosphate, 3% of hydroxypropyl starch and the balance of water.
6. The amino acid facial cleanser of any one of claims 1 to 5, wherein the sodium hyaluronate is a high affinity sodium hyaluronate.
7. The amino acid facial cleanser according to any one of claims 1 to 5, characterized by at least one of the following (a) - (g):
(a) The antioxidant is at least one of p-hydroxyacetophenone, phenoxyethanol and alkyl dihydric alcohol;
(b) The pH regulator is at least one of citric acid and lactic acid;
(c) The skin conditioner is at least one of betaine salicylic acid, sophorolipid, lignum Santali albi extract, carbon powder, lactic acid and azelaic acid;
(d) The aromatic is daily essence;
(e) The filler is at least one of sodium polyacrylate and kaolin;
(f) The chelating agent is at least one of EDTA disodium, octanoyl hydroxamic acid and sodium phytate;
(g) The cooling agent is at least one of menthol and menthyl lactate.
8. A method of preparing an amino acid facial cleanser according to any one of claims 1 to 7, comprising the steps of:
(1) Mixing the surfactant, acrylic acid (ester) copolymer in the thickener, hydroxypropyl starch phosphate and hydroxypropyl starch, glycerin in the humectant, methyl propylene glycol and deionized water, and fully stirring at 65-80 ℃ at 20-35rpm;
(2) Cooling the mixture obtained in the step (1) to room temperature, adding the skin conditioning agent, the cooling agent, the aromatic, the pH regulator, the antioxidant, the chelating agent, the filler and the 1, 2-hexanediol in the humectant, the sodium hyaluronate, the octanediol and the beta-glucan into a main material pot, keeping the stirring speed at 25-40rpm, and uniformly stirring to obtain the amino acid oil-control facial cleanser.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310404802.8A CN116370349A (en) | 2023-04-17 | 2023-04-17 | Amino acid facial cleanser, and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310404802.8A CN116370349A (en) | 2023-04-17 | 2023-04-17 | Amino acid facial cleanser, and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116370349A true CN116370349A (en) | 2023-07-04 |
Family
ID=86978637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310404802.8A Pending CN116370349A (en) | 2023-04-17 | 2023-04-17 | Amino acid facial cleanser, and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116370349A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117281760A (en) * | 2023-11-24 | 2023-12-26 | 广州百孚润化工有限公司 | Hair-loss-preventing hair-care composition and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017095368A (en) * | 2015-11-19 | 2017-06-01 | クラシエホームプロダクツ株式会社 | Skin cleanser |
| CN108992364A (en) * | 2018-07-25 | 2018-12-14 | 广州依露美化妆品有限公司 | A kind of moisturizing mildy wash containing sodium lauroyl glutamate |
| CN110051587A (en) * | 2019-05-04 | 2019-07-26 | 广州市爱百伊生物技术有限公司 | A kind of preparation method and application of the anti-apolexis composition containing a variety of sodium hyaluronates |
| CN110151578A (en) * | 2019-07-05 | 2019-08-23 | 广东天源生物科技有限公司 | A kind of clean face cream of amino acid skin-active and preparation method thereof of mild cleaning moisturizing |
| CN114767570A (en) * | 2022-04-06 | 2022-07-22 | 浙江宜格企业管理集团有限公司 | High oil content emulsion-like cleaning product and preparation method thereof |
-
2023
- 2023-04-17 CN CN202310404802.8A patent/CN116370349A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017095368A (en) * | 2015-11-19 | 2017-06-01 | クラシエホームプロダクツ株式会社 | Skin cleanser |
| CN108992364A (en) * | 2018-07-25 | 2018-12-14 | 广州依露美化妆品有限公司 | A kind of moisturizing mildy wash containing sodium lauroyl glutamate |
| CN110051587A (en) * | 2019-05-04 | 2019-07-26 | 广州市爱百伊生物技术有限公司 | A kind of preparation method and application of the anti-apolexis composition containing a variety of sodium hyaluronates |
| CN110151578A (en) * | 2019-07-05 | 2019-08-23 | 广东天源生物科技有限公司 | A kind of clean face cream of amino acid skin-active and preparation method thereof of mild cleaning moisturizing |
| CN114767570A (en) * | 2022-04-06 | 2022-07-22 | 浙江宜格企业管理集团有限公司 | High oil content emulsion-like cleaning product and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117281760A (en) * | 2023-11-24 | 2023-12-26 | 广州百孚润化工有限公司 | Hair-loss-preventing hair-care composition and preparation method and application thereof |
| CN117281760B (en) * | 2023-11-24 | 2024-03-15 | 广州百孚润化工有限公司 | Hair-loss-preventing hair-care composition and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107011164A (en) | The polyglycerol ester of crosslinking | |
| CN115137686B (en) | Cleansing-grade amino acid shower gel | |
| CN110090182A (en) | A kind of mild bath oil and preparation method thereof | |
| CN113679638B (en) | Sensitive creatine mild and clean facial cleanser and preparation method thereof | |
| CN116370349A (en) | Amino acid facial cleanser, and preparation method and application thereof | |
| CN112245316A (en) | Amino acid shampoo composition, amino acid shampoo and preparation method thereof | |
| CN112245355B (en) | Layered essential oil bath gel with nourishing and moisturizing effects and preparation method thereof | |
| CN114191335A (en) | Natural face cream for children and preparation process thereof | |
| CN112370393B (en) | Hair washing mousse composition and preparation method and application thereof | |
| CN110893165A (en) | Skin-beautifying and moisturizing cleansing foam and preparation method thereof | |
| CN114748379A (en) | NMN-containing pure crystalline amino acid facial cleanser and preparation method thereof | |
| CN113876604B (en) | Amino acid facial cleanser with high paste forming temperature and preparation method thereof | |
| CN114366693B (en) | Shampoo bath lotion for infants | |
| CN115429738A (en) | Acne-removing repairing revitalizing essence and preparation method thereof | |
| CN112472630B (en) | Self-thickening compositions of amino acid surfactants | |
| CN112426391B (en) | Chitosan nourishing and skin moistening shower gel and preparation method thereof | |
| EP3505218B1 (en) | A gentle detergent composition for greasy and acneic skins | |
| CN112336662A (en) | Soothing shower gel and preparation method and application thereof | |
| CN112294674A (en) | Pure plant deep cleaning amino acid face cleaning mousse | |
| CN116407481B (en) | Skin care composition, bath foam and preparation method thereof | |
| CN112494397B (en) | Antibacterial shower gel containing bamboo leaf flavone and preparation method thereof | |
| CN118121515B (en) | Shampoo composition for removing dandruff, controlling oil and relieving itching, and preparation method and application thereof | |
| CN113952260B (en) | Mud film and preparation method thereof | |
| CN115737459A (en) | Body cleaning composition with moisturizing, moistening and skin nourishing effects and preparation method thereof | |
| CN115154369A (en) | Heating face cleaning product and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |