CN114028246B

CN114028246B - Anti-aging repairing composition containing acetyl gingerol and application thereof

Info

Publication number: CN114028246B
Application number: CN202111503293.1A
Authority: CN
Inventors: 钟永亮; 裴玭玉; 梁佩珊; 叶春婷; 杜志欣
Original assignee: Guangzhou Trauer Biotechnology Co ltd
Current assignee: Guangzhou Trauer Biotechnology Co ltd
Priority date: 2021-12-10
Filing date: 2021-12-10
Publication date: 2023-08-08
Anticipated expiration: 2041-12-10
Also published as: CN114028246A

Abstract

The invention discloses an anti-aging repair composition containing acetyl gingerol and application thereof. The active ingredients of the anti-aging composition comprise acetyl gingerol, vitamin C or its derivatives and collagen. In the composition, acetyl gingerol, vitamin C or derivatives thereof and collagen have synergistic effect, and can remarkably improve the anti-aging repairing effect of the skin care product. The skin care essence prepared from the anti-aging repair composition can effectively resist oxidation, repair skin barrier damage and remove wrinkles.

Description

Anti-aging repairing composition containing acetyl gingerol and application thereof

Technical Field

The invention relates to an anti-aging composition, in particular to an anti-aging repair composition containing acetyl gingerol and application thereof.

Background

Aging refers to the progressive process of functional and organic decline that occurs in the body with age. The epidermis is used as the outermost barrier of the human body, is directly contacted with the external environment, and is most easily influenced by various external factors. The skin aging is most easily and intuitively reflected the influence of age and external factors on human body aging. Aged skin is obviously characterized by skin slackening and wrinkles, and the skin at the exposed part of the body becomes rough, and the wrinkles deepen and thicken; abnormal epidermis structure, pigmentation and senile plaque; the skin elasticity is no longer relaxed; vasodilation, epidermal hyperkeratosis, etc. In aged skin, the epidermal cell regeneration is slowed down, barrier function is weakened, keratinocyte activity is reduced, repairing ability after the injury of epidermis is weakened, wherein the weakening of barrier function leads to skin dryness, desquamation, wrinkles and the like. The number of fibroblasts in dermis of aged skin gradually decreases, the ability to synthesize collagen and elastin decreases, and the proportion of type I collagen and type III collagen becomes smaller, collagen fibers become thicker, and abnormal cross-linking occurs. Therefore, the skin anti-aging agent can reduce the percutaneous water loss of the skin, improve the antioxidant capacity of the epidermis, reduce the oxygen damage and have positive effects on the skin anti-aging.

Natural aging is unavoidable, but aging caused by external factors can be inhibited by using antioxidant products, oxygen damage of skin is reduced, and skin barrier is protected. Cosmetic compositions that repair skin barriers, reduce oxygen damage to the skin, are therefore helpful in protecting the skin, and maintaining the health of the skin on a daily basis.

An anti-aging composition with excellent effect is developed, and has very practical significance.

Disclosure of Invention

The invention aims to overcome at least one defect of the prior art and provides an anti-aging repair composition containing acetyl gingerol and application thereof.

The technical scheme adopted by the invention is as follows:

an anti-aging composition comprises an auxiliary agent and active ingredients, wherein the active ingredients comprise the following components in parts by mass: acetyl gingerol: 0.01-2 parts of at least one of vitamin C or a derivative thereof: 0.01-2 parts of collagen: 0.02-50 parts.

In some examples, the collagen is selected from at least one of gelatin, hydrolyzed collagen, human-like collagen, and active collagen.

In some examples, the collagen is active collagen.

In some examples, the derivative of vitamin C is selected from vitamin C ethyl ether, tetraisopalmitate ascorbate, ascorbyl glucoside, magnesium ascorbyl phosphate, dipalmitate ascorbate.

In some examples, the active ingredients are in a mass ratio of: 0.2 to 2 parts of acetyl gingerol, 0.5 to 2 parts of vitamin C or derivatives thereof and 25 to 30 parts of active collagen.

In some examples, the active ingredients are in a mass ratio of: 0.2 to 2 parts of acetyl gingerol, 0.2 to 2 parts of vitamin C ethyl ether and 25 to 30 parts of active collagen.

In some examples, the adjuvant includes a solvent.

In some examples, the solvent is a mixed solution of a polyol and water.

In some examples, the solvent comprises 5 to 95% of the total mass of the anti-aging composition.

In some examples, the solvent comprises 35 to 85% of the total mass of the anti-aging composition.

In some examples, the polyol is selected from at least one of glycerol, 1, 3-propanediol, 1, 3-butanediol, pentanediol, hexanediol, ethoxydiglycol.

In some examples, the polyol is 1, 3-butanediol, and the mass percent of 1, 3-butanediol in the solvent is 0.4-25%, preferably 2-15%.

In a second aspect of the invention, there is provided:

a skin care product having added thereto an anti-aging composition according to the first aspect of the present invention.

In some examples, the skin care product further comprises at least one of a viscosity modifier, a humectant, and a pH modifier.

In some examples, the skin care product is in a dosage form selected from at least one of an aqueous solution, an emulsion, a cream, and a facial mask.

The beneficial effects of the invention are as follows:

according to some examples of the invention, acetyl gingerol, vitamin C or derivatives thereof and collagen have synergistic effects, so that the anti-aging repairing effect of the skin care product can be remarkably improved.

Some examples of the present invention utilize the anti-aging treatment composition to prepare skin care serum that is effective in resisting oxidation, treating skin barrier damage and removing wrinkles.

Drawings

FIG. 1 is a photograph of the beginning of the plaque assay;

FIG. 2 is a photograph of the patch device after 24 hours of testing time, except for the patch device;

FIG. 3 is a photograph after 1h of patch removal;

FIG. 4 is a photograph after 48 hours of patch removal;

fig. 5 is a photograph of the right eye wrinkles taken by the instrument before use and after 4 weeks of trial.

Detailed Description

Acetyl zingiberone (acetyl zingerone) is a highly effective antioxidant, and is far superior to conventional antioxidants vitamin E in terms of resistance to hydrogen peroxide radicals, hydroxyl radicals, nitric oxide radicals, singlet oxygen. And is more stable than resveratrol and vitamin E under external illumination. While the stability and safety of acetylgingerol have been shown by studies, the mechanism by which it acts in combination with other components is not known. In the prior art, no acetylgingerol product is used in skin care products.

Collagen is the most abundant protein in mammals, accounting for 25% -30% of the total protein, and widely exists in all tissues from the body surface of lower vertebrates to the body of mammals. Skin aging is mainly manifested by loss of collagen, leading to poor skin luster and elasticity, and also being a main cause of wrinkles. Reasonably supplements collagen, can better maintain moisture in skin, and improves skin luster and elasticity. The active collagen is collagen with triple helix combination, has the same structure as natural collagen, and has better activity.

In some examples, the collagen is active collagen.

The vitamin C derivative has better stability and has the same or very similar functions as the vitamin C. In some examples, the derivative of vitamin C is selected from vitamin C ethyl ether, tetraisopalmitate ascorbate, ascorbyl glucoside, magnesium ascorbyl phosphate, dipalmitate ascorbate.

In some examples, the active ingredients are in a mass ratio of: 0.2 to 2 parts of acetyl gingerol, 0.2 to 2 parts of vitamin C or derivatives thereof and 25 to 30 parts of active collagen.

Vitamin C and its derivatives have excellent free radical scavenging ability and can block melanin formation.

In some examples, the adjuvant includes a solvent.

In some examples, the solvent is a mixed solution of a polyol and water. The polyalcohol can better disperse and stabilize the collagen, has a certain moisturizing effect, and is more beneficial to playing the effects of the acetyl gingerol, the vitamin C or the derivatives thereof and the collagen.

In some examples, the solvent comprises 5 to 95% of the total mass of the anti-aging composition. The amount of solvent may be adjusted to some extent depending on the type of product.

The high content of the polyol can influence the use experience of the skin care product, and the high concentration of the polyol has irritation to skin sensitive people. In some examples, the polyol is 1, 3-butanediol, and the mass percent of 1, 3-butanediol in the solvent is 0.4-25%, preferably 2-15%.

In a second aspect of the invention, there is provided:

In some examples, the skin care product is in a dosage form selected from at least one of an aqueous solution, an emulsion, a cream, and a facial mask. Specifically, the composition can be prepared into common dosage forms such as essence, gel or spray.

The technical scheme of the invention is further described below by combining experimental data of examples.

Example 1

This example provides an anti-aging repair composition comprising, by mass, 0.01% acetogingerol, 0.01% vitamin C ethyl ether, 0.02% active collagen, 0.4% 1, 3-butanediol, and 99.56% water.

Example 2

This example provides an anti-aging repair composition comprising, by mass, 0.05% acetogingerol, 0.05% vitamin C ethyl ether, 0.5% active collagen, 1.5% 1, 3-butanediol, and 97.9% water.

Example 3

The present example provides an anti-aging repair composition comprising, by mass, 0.2% acetyl gingerol, 0.2% vitamin C ethyl ether, 5% active collagen, 6% 1, 3-butanediol, and 88.6% water.

Example 4

The present example provides an anti-aging repair composition comprising, by mass, 0.5% acetyl gingerol, 0.5% vitamin C ethyl ether, 10% active collagen, 12% 1, 3-butanediol, and 77% water.

Example 5

The present example provides an anti-aging repair composition comprising, by mass, 0.5% acetogingerol, 1% vitamin C ethyl ether, 15% active collagen, 12% 1, 3-butanediol, and 71.5% water.

Example 6

The present example provides an anti-aging repair composition comprising, by mass, 0.5% acetogingerol, 2% vitamin C ethyl ether, 25% active collagen, 12% 1, 3-butanediol, and 60.5% water.

Example 7

The present example provides an anti-aging repair composition comprising, by mass, 1% acetozingibrone, 0.5% vitamin C ethyl ether, 30% active collagen, 25% 1, 3-butanediol, and 43.5% water.

Example 8

The present example provides an anti-aging repair composition comprising, by mass, 1% of acetozingibrone, 1% of vitamin C ethyl ether, 30% of active collagen, 25% of 1, 3-butanediol and 43% of water.

Example 9

The present example provides an anti-aging repair composition comprising, by mass, 2% acetozingibrone, 0.5% vitamin C ethyl ether, 30% active collagen, 50% 1, 3-butanediol, and 17.5% water.

Example 10

The present example provides an anti-aging repair composition comprising, by mass, 0.2% acetyl gingerol, 0.2% vitamin C ethyl ether, 30% active collagen, 6% 1, 3-butanediol, and 63.6% water.

Example 11

This example provides an anti-aging repair composition comprising, by mass, 0.05% acetogingerol, 0.05% vitamin C ethyl ether, 0.2% active collagen, 1.5% 1, 3-butanediol, and 98.2% water.

Example 12

The present example provides an anti-aging repair composition comprising, by mass, 0.5% acetogingerol, 2% vitamin C ethyl ether, 2% active collagen, 12% 1, 3-butanediol, and 83.5% water.

Example 13

The present example provides an anti-aging repair composition comprising, by mass, 0.5% acetogingerol, 1% vitamin C ethyl ether, 20% active collagen, 12% 1, 3-butanediol, and 66.5% water.

Example 14

The present example provides an anti-aging repair composition comprising, by mass, 0.5% acetyl gingerol, 0.5% vitamin C ethyl ether, 30% active collagen, 12% 1, 3-butanediol, and 57% water.

Example 15

The present example provides an anti-aging repair composition comprising, by mass, 1% acetozingibrone, 0.5% vitamin C ethyl ether, 50% active collagen, 25% 1, 3-butanediol, and 23.5% water.

Comparative example 1

This comparative example provides an anti-aging repair composition comprising, by mass, 2% of acetylgingerol, 50% of 1, 3-butanediol, and 48% of water.

Comparative example 2

This comparative example provides an anti-aging repair composition comprising, by mass, 2% vitamin C ethyl ether, 0.2% 1, 3-butanediol, and 97.8% water.

Comparative example 3

The comparative example provides an anti-aging repair composition which comprises 2% of acetylgingerol, 2% of water-soluble resveratrol, 30% of active collagen, 50% of 1, 3-butanediol and 16% of water in percentage by mass.

Comparative example 4

The comparative example provides an anti-aging repair composition comprising, by mass, 2% of vitamin C ethyl ether, 2% of water-soluble resveratrol, 30% of active collagen, 0.2% of 1, 3-butanediol and 65.8% of water.

The skin care essence is prepared by using the anti-aging repair compositions prepared in the examples and the comparative examples respectively, and the components are shown in tables 1 to 3 in percentage by mass of 100%.

The preparation method of the skin care essence comprises the following steps:

(1) Adding the phase A in sequence, stirring and heating to 60 ℃;

(2) After the phase A is dissolved uniformly, stirring and cooling to 35 ℃ for standby;

(3) Dispersing and dissolving the phase C separately for standby;

(4) Adding the phase B and the dispersed phase C into the standby phase A, stirring and dispersing uniformly, adding the phase D, stirring and dispersing uniformly.

Test example 1: skin closure patch test

The method adopted in the test is the method of the closed type patch test of human skin in the seventh chapter 2 of cosmetic safety technical Specification (2015 edition).

120 healthy subjects with no history of dermatological allergy between 20 and 50 years of age were selected and randomly divided into 10 groups. One patch was applied to the front curved side of each tester's arm, and 10 patch chambers were provided for each patch, 9 of which were dropped with test samples, and 1 patch chamber was used as a blank. The plaque room random distribution used for the application and comparative examples ensured that each application and comparative example was tested at least 4 times per test panel.

Before testing, the tested area is photographed and recorded, then a qualified spot tester is selected, 25 mu L of the skin care essence of the application examples 1-15 and the skin care essence of the comparison examples 1-4 are respectively dripped into the spot tester, the tested object is removed after 24 hours, and skin reaction is observed after 0.5, 24 and 48 hours, wherein the skin abnormality phenomenon needs photographing and recording.

The results of the patch test are shown in table 5 and fig. 1 to 4.

120 people participate in the test, and 120 parts of effective data are recovered. The test result shows that the product has no positive phenomenon, and the product has high safety and small irritation.

Test example 2: repair capability test of essence

The total of 120 people in the group of the experimental subjects are aged between 18 and 50 years, and are divided into 10 groups randomly. Each tester's two hands and arms were divided into 8 areas altogether, i.e., each arm included 3 test samples and 1 blank. While ensuring that each application and comparative example was tested at least 3 times per test panel.

The repair ability test is characterized by a percutaneous moisture loss (TEWL) value. The percutaneous moisture loss measurement instrument used in the test was a Vapometer percutaneous moisture loss measurement instrument pair from Delfin corporation. The specific method comprises the following steps: the tested part of the test subject is cleaned by clear water, and is sucked by chipless water-absorbing dry paper towels, 4 areas of 4X 4cm are sequentially drawn on the curved sides of the left forearm and the right forearm by using a marker pen, the test samples and the blank control are distinguished by numbers, the examples and the comparative examples are randomly distributed, and each test group is ensured to be tested at least 3 times; before testing, the test is required to be statically placed in a testing environment conforming to the standard for 15-30min, and then at least three times of testing are carried out on the corresponding testing area, and an average value is taken as an initial value. Samples of 0.1ml were smeared on the corresponding areas and TEWL values were measured at 1, 2, 3, 4, 6, 8h, respectively. The test results are shown in tables 6 and 7.

Rate of decrease in percutaneous loss of water =A negative value indicates a decrease in the percutaneous loss of water and a positive value indicates an increase in the percutaneous loss of water.

As can be seen from the data in tables 6 and 7, the data of application examples 7 to 10 are better overall than those of comparative examples 1 to 4, demonstrating that application examples 7 to 10 have a synergistic effect in repair.

Test example 3: wrinkle removing capability test of essence

The test group 190 is divided into 10 groups, and the ages are 18-50 years.

The changes in wrinkles at the corners of the eyes before and after use of the product were measured in subjects using an Antera3D instrument from Miravex Inc. After the subjects cleaned their faces in the morning and evening, the wrinkles were analyzed with the instrument for changes after two weeks and four weeks of use with an equivalent amount of serum.

The test results are shown in Table 8 and FIG. 5.

As is clear from the data in Table 8, the wrinkles of the subjects were improved after the essence was used, and the anti-wrinkle and anti-oxidation capabilities of application examples 3 to 15 were fully played as a comparative example, and in particular, the improvement of skin wrinkles was remarkable in application examples 6 to 10. The application example of the invention has wide anti-wrinkling and anti-oxidation effects and has synergistic effect.

The above description of the present invention is further illustrated in detail and should not be taken as limiting the practice of the present invention. It is within the scope of the present invention for those skilled in the art to make simple deductions or substitutions without departing from the concept of the present invention.

Claims

1. An anti-aging composition comprising an auxiliary agent and an active ingredient, characterized in that: the active ingredients comprise the following components in parts by mass: 0.2 to 2 parts of acetyl gingerol, 0.5 to 2 parts of vitamin C or derivatives thereof and 25 to 30 parts of active collagen;

the vitamin C derivative is selected from vitamin C ethyl ether, ascorbyl tetraisopalmitate, ascorbyl glucoside, magnesium ascorbyl phosphate, and ascorbyl dipalmitate.

2. The anti-aging composition of claim 1, wherein: the auxiliary agent comprises a solvent.

3. The anti-aging composition of claim 2, wherein: the solvent is a mixed solution of polyol and water.

4. An anti-ageing composition according to claim 2 or 3, characterised in that: the solvent accounts for 5-95% of the total mass of the anti-aging composition.

5. The anti-aging composition of claim 4, wherein: the solvent accounts for 35-85% of the total mass of the anti-aging composition.

6. An anti-aging composition according to claim 3, wherein: the polyalcohol is at least one selected from glycerol, 1, 3-propylene glycol, 1, 3-butanediol, pentanediol, hexanediol and ethoxydiglycol.

7. The anti-aging composition of claim 6, wherein: the polyalcohol is 1, 3-butanediol, and the mass percentage of the polyalcohol in the solvent is 0.4-25%.

8. A skin care product, characterized in that: an anti-aging composition according to any one of claims 1 to 7.

9. The skin care product of claim 8, wherein: and at least one of viscosity regulator, humectant and pH regulator.

10. The skin care product according to claim 8 or 9, characterized in that: the preparation is at least one selected from water aqua, emulsion, cream and facial mask.