CN110638670A - High-permeability moisturizing composition, skin moisturizer and preparation method - Google Patents
High-permeability moisturizing composition, skin moisturizer and preparation method Download PDFInfo
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- CN110638670A CN110638670A CN201910790545.XA CN201910790545A CN110638670A CN 110638670 A CN110638670 A CN 110638670A CN 201910790545 A CN201910790545 A CN 201910790545A CN 110638670 A CN110638670 A CN 110638670A
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- salt
- skin
- water
- permeability
- permeability moisturizing
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- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 239000004909 Moisturizer Substances 0.000 title abstract description 6
- 230000001333 moisturizer Effects 0.000 title abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 54
- -1 acetyl chitosamine Chemical compound 0.000 claims abstract description 43
- 235000002639 sodium chloride Nutrition 0.000 claims abstract description 40
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 27
- 229940074992 chondrus crispus extract Drugs 0.000 claims abstract description 26
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 21
- 239000000194 fatty acid Substances 0.000 claims abstract description 21
- 229930195729 fatty acid Natural products 0.000 claims abstract description 21
- 150000003839 salts Chemical class 0.000 claims abstract description 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 20
- 239000011780 sodium chloride Substances 0.000 claims abstract description 19
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 17
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 17
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical group CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 42
- 239000006210 lotion Substances 0.000 claims description 37
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 21
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 21
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 19
- 239000002904 solvent Substances 0.000 claims description 17
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 15
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 15
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 15
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 15
- 229940108925 copper gluconate Drugs 0.000 claims description 15
- 150000002148 esters Chemical class 0.000 claims description 15
- 125000005456 glyceride group Chemical group 0.000 claims description 15
- 229960001983 magnesium aspartate Drugs 0.000 claims description 15
- RXMQCXCANMAVIO-CEOVSRFSSA-L magnesium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound [H+].[H+].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O RXMQCXCANMAVIO-CEOVSRFSSA-L 0.000 claims description 15
- 229940057910 shea butter Drugs 0.000 claims description 15
- 239000011670 zinc gluconate Substances 0.000 claims description 15
- 235000011478 zinc gluconate Nutrition 0.000 claims description 15
- 229960000306 zinc gluconate Drugs 0.000 claims description 15
- 230000035699 permeability Effects 0.000 claims description 14
- 229940119170 jojoba wax Drugs 0.000 claims description 7
- 239000003755 preservative agent Substances 0.000 claims description 7
- 230000002335 preservative effect Effects 0.000 claims description 7
- 230000001502 supplementing effect Effects 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 150000001879 copper Chemical class 0.000 claims description 2
- 159000000003 magnesium salts Chemical class 0.000 claims description 2
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- 238000003756 stirring Methods 0.000 claims description 2
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- 238000000034 method Methods 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 241000588724 Escherichia coli Species 0.000 abstract description 2
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 72
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000005456 alcohol based solvent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
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- 238000000605 extraction Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
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- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940091250 magnesium supplement Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
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- 210000002966 serum Anatomy 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The invention discloses a high-permeability moisturizing composition which comprises a Chondrus crispus extract, acetyl chitosamine, polyethylene glycol fatty acid ester, organic salt and sea salt. The high-permeability moisturizing composition can effectively replenish water and deeply moisturize, can promote the skin to absorb water-soluble and fat-soluble active ingredients, can effectively inhibit golden yellow staphylococcus aureus and escherichia coli, and can be applied to various skin care products. The invention also provides a skin moisturizer containing the high-permeability moisturizing composition and a preparation method thereof, and the skin moisturizer obtained by the preparation method has better storage resistance.
Description
Technical Field
The invention relates to a daily-use fine chemical product, in particular to a high-permeability moisturizing composition, a skin moisturizer and a preparation method.
Background
The skin is the largest organ of the human body and plays an important role in preventing water loss of the human body, external pollution, irritation and the like. With the internal and external reasons such as age, working pressure, living habits, ultraviolet irradiation, environmental pollution and the like, the skin is more severely deficient in water.
Skin care products on the market at present mainly focus on products such as moisturizing water, lotion, cream and the like. These products are mostly made by adding emulsifiers, thickeners and conditioning ingredients to a moisturizing solvent based on water and alcohol. The moisturizing component mainly comprises water and polyhydric alcohol, while the water is volatile, and the polyhydric alcohol is relatively difficult to volatilize but is easy to generate skin irritation.
Many moisturizing components mainly comprising water and polyhydric alcohol have low permeability, stay on the skin surface, and are prevented from further penetration after the skin stratum corneum is soaked and foamed after contacting the skin. There are also products that aim to increase the residence time of moisturizing ingredients, mainly by adding ingredients such as carbomers that increase viscosity to form a high viscosity serum, but this also reduces the freshness of the skin care product.
Sensitive skin has a certain relationship with the structure of the skin itself and the immediate state of the sensory nerves in addition to the influence of contact and action of specific substances and specific irradiation, and also needs to have better adaptability to the sensitive skin for high-permeability moisturizing ingredients.
With the improvement of living standard, the product is environment-friendly, has low stimulation, and can effectively penetrate skin and keep moisture, so that the product is more easily accepted by the market.
Disclosure of Invention
In order to overcome the disadvantages of the prior art, one of the objects of the present invention is to provide a moisturizing composition with high permeability which can effectively promote the permeation of active ingredients and has low skin sensitization.
The invention also aims to provide a high-permeability moisturizing skin care lotion containing the high-permeability moisturizing composition, wherein the skin care lotion has small irritation to skin and can moisturize for a long time.
The invention also aims to provide a preparation method of the high-permeability moisturizing skin care lotion, which can obtain the high-permeability moisturizing skin care lotion with uniform components and thin texture.
One of the purposes of the invention is realized by adopting the following technical scheme:
a high permeability moisturizing composition comprises Chondrus crispus extract, acetyl chitosamine, polyethylene glycol fatty acid ester, organic salt and sea salt.
The high permeability moisturizing composition forms a network structure in the stratum corneum by the high water absorption and retention of the Chondrus crispus extract to maintain the water inside the skin; the polyethylene glycol fatty acid ester has better hydrophile lipophilicity, forms water locking anchor points on the surface of the skin and promotes the permeability of mineral components, organic nutrient components and alcohol solvents to the skin cuticle; the acetyl chitosamine has promoting effect on the generation of hyaluronic acid; the organic salt and sea salt provide environment similar to normal saline for skin, provide microelements such as magnesium, zinc, copper and the like for cells, effectively activate the activity of the cells, and reduce bacterial proliferation caused by high concentration of nutrient components on the surface of the skin; the high-permeability moisturizing composition has high repairing, moisturizing and nursing effects synergistically.
Further, the polyethylene glycol fatty acid ester is jojoba wax PEG-120 ester and/or PEG-75 shea butter glyceride. The two polyethylene glycol fatty acid esters have a relatively proper hydrophilic-lipophilic HLB balance value, can effectively preserve moisture, promote the permeability of effective components, promote the absorption of active substances by skin, and can effectively improve the skin. When the fatty acid molecules are inserted into the hydrophobic structure of lipid bilayer of stratum corneum lipid, the bilayer is twisted due to the cis structure of the unsaturated hydrophobic chain, so as to form a fine flowing channel easy to permeate, and effectively influence the ordered arrangement of the lipid structure of stratum corneum, thereby promoting the percutaneous absorption of active substances.
Further, the organic salt is one or more than two of organic magnesium salt, organic copper salt and organic zinc salt. The three organic salts can effectively activate the cell activity for the skin and provide permeable trace elements for the cell metabolism. More specifically, the organic salt is one or more of magnesium aspartate, copper gluconate, and zinc gluconate. The three organic salts have good affinity with cells, can effectively permeate into skin, promote metabolism of the skin and repair the skin.
Specifically, the high-permeability moisturizing composition is composed of the following components in parts by weight: 2.0-10.0 parts of Chondrus crispus extract, 0.2-0.7 part of acetyl chitosamine, 0.1-1.0 part of polyethylene glycol fatty acid ester, 0.15-0.30 part of organic salt, and 0.05-0.2 part of sea salt.
The second purpose of the invention is realized by adopting the following technical scheme:
a high-permeability moisturizing skin care lotion is prepared from the following components in percentage by weight: 2.0-10.0% of Chondrus crispus extract, 0.2-0.7% of acetyl chitosamine, 0.1-1.0% of polyethylene glycol fatty acid ester, 0.15-0.30% of organic salt, 0.05-0.2% of sea salt, 0.2-0.7% of preservative and solvent for supplementing 100%.
The high-permeability moisturizing skin care lotion can be directly used on the surface of skin and is suitable for most of skin, including sensitive skin. After the skin care product is used, the skin care product has good skin feel and smooth feel, can keep the skin moist for a long time after being used, promotes the generation of hyaluronic acid and cell metabolism of the skin, effectively resists wrinkles and removes wrinkles after being used for a long time, and improves the elasticity and luster of the skin.
Further, the preservative is p-hydroxyacetophenone; the solvent includes water, butanediol, and 1, 2-hexanediol. In addition, the solvent 1, 2-hexanediol used in the skin care lotion can be used as a solvent and a preservative simultaneously, so that the using amount of p-hydroxyacetophenone is reduced, and the skin care lotion is reduced in irritation to the skin.
Further, the high-permeability moisturizing skin care lotion is prepared from the following components in percentage by weight: 4.0-6.0% of Chondrus crispus extract, 0.4-0.5% of acetyl chitosamine, 0.2-0.4% of Hojoba wax PEG-120 esters, 0.2-0.4% of PEG-75 shea butter glycerides, 0.07-0.13% of magnesium aspartate, 0.05-0.1% of copper gluconate, 0.01-0.05% of zinc gluconate, 0.4-0.5% of p-hydroxyacetophenone, 1.0-5.0% of butanediol, 0.2-1.0% of 1, 2-hexanediol and water for 100%.
The third purpose of the invention is realized by adopting the following technical scheme:
a preparation method of high-permeability moisturizing skin care lotion comprises the following steps:
1) adding 5-20 times of solvent into polyethylene glycol fatty acid ester and antiseptic, stirring and dissolving;
2) dissolving Chondrus crispus extract and acetyl chitosamine in 3-6 times of solvent;
3) dissolving organic salt and sea salt in 3-6 times of solvent;
4) adding the solution obtained in the step 2) into the solution obtained in the step 1), and finally adding the solution obtained in the step 3) and the rest of solvent.
The preparation method can effectively and uniformly disperse the effective components in a pre-dissolving manner, and finally obtains the skin care lotion with uniform texture and stable system, and the skin care lotion is stable and is not easy to produce oil or precipitate under the high-temperature and high-humidity environment.
Compared with the prior art, the invention has the beneficial effects that:
the high-permeability moisturizing composition disclosed by the invention forms a net-shaped water-locking barrier in the stratum corneum by the high-water-locking carrageen crispus extract to maintain the skin moisture, moisturizes and thickens the high-hydrophily and lipophilicity soluble polyethylene glycol fatty acid ester and promotes the transdermal absorbability of water-soluble and fat-soluble active ingredients, enables the skin to keep elasticity by the generation promoting effect of the high-permeability chitosan polyamine, provides trace elements for the metabolism of skin cells by organic salt and sea salt, enables the skin moisturizer to keep the environment of physiological saline, and inhibits the proliferation of bacteria, and finally is suitable for sensitive skin after being acted on the skin, so that the skin can be moisturized for a long term, and has elasticity and luster;
the high permeability moisturizing composition can be added into most skin care components, including direct-application skin care lotion or facial mask lotion with short time concentration effect, has good hydrophilic and lipophilic system, and has good compatibility with other water-based or oil-based care components;
the high-permeability moisturizing skin care lotion provided by the invention has good skin feel and refreshing property when being applied to skin, can lock water for a long time after being used, keep the skin elasticity, improve the skin color and simultaneously can effectively repair sensitive skin;
the high-permeability moisturizing skin care lotion provided by the invention can form an aqueous emulsion system with uniform texture and stable system, has better stability, and is not easy to produce oil or precipitate under a long-time high-temperature and high-humidity environment.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.
The present invention provides a highly osmotic moisturizing composition comprising Chondrus crispus extract, acetyl chitosamine, polyethylene glycol fatty acid ester, organic salt and sea salt.
The Chondrus Crispus (Chondrus Crispus) extract is similar to carrageenan with the serial number (08631) in the catalogue of used cosmetic raw materials (2015 edition) in China, and is an extract which is obtained by alkaline extraction and modification of Chondrus Crispus and takes polysaccharide as a main component, wherein the average molecular weight of the polysaccharide is 10 ten thousand daltons, and the Chondrus Crispus extract has a strong moisturizing effect.
Chitosamine, INCI name: acetylchitosamine, a basic unit of many important polysaccharides and glycoproteins in the Chinese catalog of names of used cosmetic raw materials (2015 edition), is an important prerequisite for the synthesis of bifidus factors. The application uses the compatibility of the acetyl chitosamine and the extract of the carrageen crispus, has strong permeability, can effectively improve the affinity of polysaccharide in the carrageen crispus and the surface of skin on one hand, and can effectively improve the secretion of the polysaccharide such as hyaluronic acid of skin cells on the other hand, so as to achieve the technical effects of deep moisture preservation and long-acting water locking.
The polyethylene glycol fatty acid ester is a skin conditioner with hydrophile and lipophile, has a similar structure with skin fatty acid, when fatty acid molecules are inserted into a lipid bilayer hydrophobic structure of stratum corneum lipoid, due to a cis-structure of unsaturated hydrophobic chains, the bilayer is twisted to form a fine flow channel easy to permeate, the ordered arrangement of the stratum corneum lipid structure is effectively influenced, and therefore transdermal absorption of active substances is promoted. When fatty acid molecules are inserted into a lipid bilayer hydrophobic structure of the cuticle lipid, due to the cis-structure of the unsaturated hydrophobic chain, the bilayer is twisted to form a fine flow channel easy to permeate, the ordered arrangement of the cuticle lipid structure is effectively influenced, and the percutaneous absorption of active substances is promoted.
The organic salt and the sea salt provide better physiological saline environment and mineral substances for skin cells through the matching of the inorganic salt and the organic salt, promote the metabolism of the skin cells, enhance the immune function of the cells, repair damaged skin and have definite antibacterial action on staphylococcus aureus, escherichia coli and the like.
The invention provides a high-permeability moisturizing skin care lotion which is prepared from the following components in percentage by weight: 2.0-10.0% of Chondrus crispus extract, 0.2-0.7% of acetyl chitosamine, 0.1-1.0% of polyethylene glycol fatty acid ester, 0.15-0.30% of organic salt, 0.05-0.2% of sea salt, 0.2-0.7% of preservative and solvent for supplementing 100%.
Namely, the high-permeability moisturizing skin care lotion is composed of the high-permeability moisturizing composition, a preservative and a solvent. The high-permeability moisturizing lotion can be used for long-term moisturizing.
The following are specific examples of the present invention, and raw materials, equipments and the like used in the following examples can be obtained by purchasing them unless otherwise specified.
In the following embodiments, the water is pure water or deionized water, unless otherwise specified.
Example 1:
a high-permeability moisturizing skin care lotion is prepared from the following components in percentage by weight: 2.0% of Chondrus crispus extract, 0.2% of acetyl chitosamine, 0.05% of Hojoba wax PEG-120 esters, 0.05% of PEG-75 shea butter glycerides, 0.07% of magnesium aspartate, 0.05% of copper gluconate, 0.01% of zinc gluconate, 0.2% of p-hydroxyacetophenone, 1.0% of butanediol, 0.2% of 1, 2-hexanediol and water to make up 100%.
The preparation method of the high-permeability moisturizing skin care lotion comprises the following steps:
1) mixing and dissolving jojoba wax PEG-120 esters, PEG-75 shea butter glycerides, p-hydroxyacetophenone and butanediol;
2) dissolving Chondrus crispus extract, acetyl chitosamine and 1, 2-hexanediol in 3 times of water;
3) dissolving magnesium aspartate, copper gluconate, zinc gluconate and sea salt in 5 times of water;
4) adding the solution obtained in the step 2) into the solution obtained in the step 1), and adding the solution obtained in the step 3) and the balance of water.
Example 2:
a high-permeability moisturizing skin care lotion is prepared from the following components in percentage by weight: 4.0% of Chondrus crispus extract, 0.4% of acetyl chitosamine, 0.2% of Hojoba wax PEG-120 esters, 0.2% of PEG-75 shea butter glycerides, 0.07% of magnesium aspartate, 0.05% of copper gluconate, 0.01% of zinc gluconate, 0.4% of p-hydroxyacetophenone, 2.0% of butanediol, 0.2% of 1, 2-hexanediol and water to make up 100%.
The preparation method of the high-permeability moisturizing skin care lotion comprises the following steps:
1) mixing and dissolving jojoba wax PEG-120 esters, PEG-75 shea butter glycerides, p-hydroxyacetophenone and butanediol;
2) dissolving Chondrus crispus extract, acetyl chitosamine and 1, 2-hexanediol with 4 times of water;
3) dissolving magnesium aspartate, copper gluconate, zinc gluconate and sea salt in 4 times of water;
4) adding the solution obtained in the step 2) into the solution obtained in the step 1), and adding the solution obtained in the step 3) and the balance of water.
Example 3:
a high-permeability moisturizing skin care lotion is prepared from the following components in percentage by weight: 5.0% Chondrus crispus extract, 0.5% acetyl chitosamine, 0.4% Hojoba wax PEG-120 esters, 0.4% PEG-75 shea butter glycerides, 0.13% magnesium aspartate, 0.10% copper gluconate, 0.05% zinc gluconate, 0.4% p-hydroxyacetophenone, 3.0% butylene glycol, 0.2% 1, 2-hexanediol and water to make up to 100%.
The preparation method of the high-permeability moisturizing skin care lotion comprises the following steps:
1) mixing and dissolving jojoba wax PEG-120 esters, PEG-75 shea butter glycerides, p-hydroxyacetophenone and butanediol;
2) dissolving Chondrus crispus extract, acetyl chitosamine and 1, 2-hexanediol with 5 times of water;
3) dissolving magnesium aspartate, copper gluconate, zinc gluconate and sea salt in 3 times of water;
4) adding the solution obtained in the step 2) into the solution obtained in the step 1), and adding the solution obtained in the step 3) and the balance of water.
Example 4:
a high-permeability moisturizing skin care lotion is prepared from the following components in percentage by weight: 6.0% Chondrus crispus extract, 0.5% of acetyl chitosamine, 0.4% of Hojoba wax PEG-120 esters, 0.4% of PEG-75 shea butter glycerides, 0.07% of magnesium aspartate, 0.05% of copper gluconate, 0.05% of zinc gluconate, 0.5% of p-hydroxyacetophenone, 5.0% of butanediol, 1.0% of 1, 2-hexanediol and water to make up 100%.
The preparation method of the high-permeability moisturizing skin care lotion comprises the following steps:
1) mixing and dissolving jojoba wax PEG-120 esters, PEG-75 shea butter glycerides, p-hydroxyacetophenone and butanediol;
2) dissolving Chondrus crispus extract, acetyl chitosamine and 1, 2-hexanediol in 3 times of water;
3) dissolving magnesium aspartate, copper gluconate, zinc gluconate and sea salt in 5 times of water;
4) adding the solution obtained in the step 2) into the solution obtained in the step 1), and adding the solution obtained in the step 3) and the balance of water.
Example 5:
a high-permeability moisturizing skin care lotion is prepared from the following components in percentage by weight: 10.0% Chondrus crispus extract, 0.7% of acetyl chitosamine, 0.5% of Hojoba wax PEG-120 esters, 0.5% of PEG-75 shea butter glycerides, 0.13% of magnesium aspartate, 0.10% of copper gluconate, 0.05% of zinc gluconate, 1.0% of p-hydroxyacetophenone, 5.0% of butanediol, 0.7% of 1, 2-hexanediol and water to make up 100%.
The preparation method of the high-permeability moisturizing skin care lotion comprises the following steps:
1) mixing and dissolving jojoba wax PEG-120 esters, PEG-75 shea butter glycerides, p-hydroxyacetophenone and butanediol;
2) dissolving Chondrus crispus extract, acetyl chitosamine and 1, 2-hexanediol with 5 times of water;
3) dissolving magnesium aspartate, copper gluconate, zinc gluconate and sea salt in 3 times of water;
4) adding the solution obtained in the step 2) into the solution obtained in the step 1), and adding the solution obtained in the step 3) and the balance of water.
Comparative example 1:
the moisturizing water is prepared from the following components in percentage by weight: 0.2% of p-hydroxyacetophenone, 1.0% of butanediol, 0.2% of 1, 2-hexanediol and water to make up 100%.
Comparative example 2:
the moisturizing water is prepared from the following components in percentage by weight: 0.4% of p-hydroxyacetophenone, 2.0% of butanediol, 0.2% of 1, 2-hexanediol and water to make up 100%.
Comparative example 3:
the moisturizing water is prepared from the following components in percentage by weight: 0.4% of p-hydroxyacetophenone, 3.0% of butanediol, 0.2% of 1, 2-hexanediol and water to make up 100%.
Comparative example 4:
the moisturizing water is prepared from the following components in percentage by weight: 0.5% of p-hydroxyacetophenone, 5.0% of butanediol, 1.0% of 1, 2-hexanediol and water to make up 100%.
Comparative example 5:
the moisturizing water is prepared from the following components in percentage by weight: 1.0% of p-hydroxyacetophenone, 5.0% of butanediol, 0.7% of 1, 2-hexanediol and water to make up 100%.
Performance detection
1. Measurement of moisturizing Effect
Experiment design: each example selected 40 valid subjects for testing, randomized into 5 groups. Before the test, the testee cleans the inner sides of the forearms of both hands by workers; measuring a zone mark on the inner forearm group number of a subject, wherein the area of the test zone is 3cm multiplied by 3cm, the inner forearm area of the left hand of each tester randomly selects a product of example 1-5 or comparative example 1-5, and the corresponding position of the right hand is not treated to be used as a blank control; carrying out an initial value (0h) test of the skin stratum corneum moisture; applying product to forearm inner side of subject in an amount of 0.0171-0.0189 g; the moisture content of the stratum corneum was measured using a skin moisture content measuring probe at 2h, 4h, 6h, 8h, 10h, and 12h, and the results were expressed as nh (n ═ 2, 4, 6, 8, 10, and 12), and averaged, and the results are shown in the following table.
TABLE 1 moisture retention test results
As can be seen from Table 1, the high-permeability moisturizing composition obtained by the invention has a moisturizing effect of more than 50% for 12 hours compared with a comparative example containing only auxiliary materials and a blank control without treatment, and meets the requirements of deep water replenishing and long-term water locking.
2. Accelerated thermal stability test
10mL of the moisturizing lotion obtained in examples 1 to 5 was taken from a 10mL glass sample bottle, sealed with a lid, placed in an oven at a temperature of 52. + -. 2 ℃ and stored for 7 days, and then the lotion in the sample bottle was observed, with the results shown in the following table:
TABLE 27 days accelerated thermal stability test
| Sample morphology | |
| Example 1 | Is in uniform liquid phase, is transparent, has no layered oil drop and no visible floccule |
| Example 2 | Is in uniform liquid phase, is transparent, has no layered oil drop and no visible floccule |
| Example 3 | Is uniformLiquid phase, transparency, no layered oil drop and no floccule |
| Example 4 | Is in uniform liquid phase, is transparent, has no layered oil drop and no visible floccule |
| Example 5 | Is in uniform liquid phase, is transparent, has no layered oil drop and no visible floccule |
As can be seen from the above table, the high permeability moisturizing composition obtained by the present application has better stability and can resist high temperature storage.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (10)
1. A highly osmotic moisturizing composition comprising Chondrus crispus extract, acetyl chitosamine, polyethylene glycol fatty acid ester, organic salt and sea salt.
2. The high permeability moisturizing composition of claim 1, wherein the polyethylene glycol fatty acid ester is a jojoba wax PEG-120 ester and/or a PEG-75 shea butter glyceride.
3. The high permeability moisturizing composition of claim 1, wherein the organic salt is one or more of an organic magnesium salt, an organic copper salt, and an organic zinc salt.
4. The high-permeability moisturizing composition of claim 3, wherein the organic salt is one or more of magnesium aspartate, copper gluconate, and zinc gluconate.
5. The high permeability moisturizing composition of claim 1, consisting of, by weight: 2.0-10.0 parts of Chondrus crispus extract, 0.2-0.7 part of acetyl chitosamine, 0.1-1.0 part of polyethylene glycol fatty acid ester, 0.15-0.30 part of organic salt and 0.05-0.2 part of sea salt.
6. The high-permeability moisturizing skin care lotion is characterized by being prepared from the following components in percentage by weight: 2.0-10.0% of Chondrus crispus extract, 0.2-0.7% of acetyl chitosamine, 0.1-1.0% of polyethylene glycol fatty acid ester, 0.15-0.30% of organic salt, 0.05-0.2% of sea salt, 0.2-0.7% of preservative and solvent for supplementing 100%.
7. The high permeability moisturizing lotion of claim 6, wherein the preservative is p-hydroxyacetophenone; the solvent includes water, butanediol, and 1, 2-hexanediol.
8. The high-permeability moisturizing skin care lotion of claim 6, prepared from the following components in percentage by weight: 4.0-6.0% of Chondrus crispus extract, 0.4-0.5% of acetyl chitosamine, 0.2-0.4% of Hojoba wax PEG-120 esters, 0.2-0.4% of PEG-75 shea butter glycerides, 0.07-0.13% of magnesium aspartate, 0.05-0.1% of copper gluconate, 0.01-0.05% of zinc gluconate, 0.4-0.5% of p-hydroxyacetophenone, 1.0-5.0% of butanediol, 0.2-1.0% of 1, 2-hexanediol and water for 100%.
9. The high-permeability moisturizing lotion of claim 8, prepared from the following components in weight percent: 5.0% Chondrus crispus extract, 0.5% of acetyl chitosamine, 0.2% of Hojoba wax PEG-120 esters, 0.2% of PEG-75 shea butter glycerides, 0.1% of magnesium aspartate, 0.07% of copper gluconate, 0.03% of zinc gluconate, 0.5% of p-hydroxyacetophenone, 3.0% of butanediol, 0.5% of 1, 2-hexanediol and water to make up 100%.
10. A method for preparing the high permeability moisturizing lotion of any one of claims 6-9, comprising the steps of:
1) adding 5-20 times of solvent into polyethylene glycol fatty acid ester and antiseptic, stirring and dissolving;
2) dissolving Chondrus crispus extract and acetyl chitosamine in 3-6 times of solvent;
3) dissolving organic salt and sea salt in 3-6 times of solvent;
4) adding the solution obtained in the step 2) into the solution obtained in the step 1), and finally adding the solution obtained in the step 3) and the rest of solvent.
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