CN110522671A - A kind of depth moisturizing compound and preparation method thereof - Google Patents
A kind of depth moisturizing compound and preparation method thereof Download PDFInfo
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- CN110522671A CN110522671A CN201910974714.5A CN201910974714A CN110522671A CN 110522671 A CN110522671 A CN 110522671A CN 201910974714 A CN201910974714 A CN 201910974714A CN 110522671 A CN110522671 A CN 110522671A
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- moisturizing compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of depth moisturizing compound and preparation method thereof, the depth moisturizing compound is made of following parts by weight ingredient: 0.05 ~ 1 part of hyaluronic acid, 0.04 ~ 2 part of transdermal fibronectin, 0.06 ~ 4 part of erythrothioneine, 4 ~ 40 parts of dispersing agent, 5 ~ 60 parts of solvent.The depth moisturizing compound the preparation method comprises the following steps: received according to the ratio with dispersing agent dispersed transparent matter acid and erythrothioneine, be subsequently added to be stirred in solvent to being completely dissolved, be eventually adding transdermal fibronectin, stir completely to get the depth moisturizing compound.A kind of depth moisturizing compound proposed by the present invention, using hyaluronic acid as the primary efficacy object of skin moisturizing, transdermal fibronectin is added simultaneously and promotes infiltration, realize depth moisturizing, finally it is aided with erythrothioneine, improves and repair skin barrier, locks the moisture inside skin, comfortable skin sense can not only be provided, skin health is additionally aided.
Description
Technical field
The present invention relates to a kind of compounds, and in particular to a kind of depth moisturizing compound and preparation method thereof.
Background technique
Water is Source of life, and water shortage can bring a series of skin problem, such as have dry skin, have tight feeling, occur scurf,
Itch etc., long-term water shortage but will accelerate skin aging, wrinkle, color spot occur, and become coarse, obscure, nonelastic.In recent years,
Continuous with cosmetic science knowledge is popularized, and people also gradually appreciate moisturizing to the importance of skin care.Moisturizing is protected
It is wet gradually at a primary demand of skin care, various replenishing water and preserving moisture products on the market also emerge one after another.Presently commercially available benefit
Water moisturizer, relying primarily on addition polyalcohol etc. has hygroscopic moisturizer, passes through the hydrone to dissociate in absorption air
To reach moisturizing effect.However, some researches show that have hygroscopic cosmetic applying when skin surface, can not only adsorb
Moisture in air, equally can also adsorb the moisture of skin interior tissue, although skin surface cuticula seems moisturizing,
Allow inside skin more water shortage in fact.In addition, the first line of defence of the cuticula as skin barrier, is preventing beneath tissue dewatering
While, also prevent the moisture of skin surface to enter deep layer skin.Therefore, real moistening effect does not reach people's
It is expected that the moisturizer with deeply preserving moisture effect becomes the new pursuit of people.
Hyaluronic acid (Hyaluronic Acid, HA) also known as sodium hyaluronate, Hyaluronic Acid, commodity hyaluronic acid are generally transparent
Matter acid sodium.It is widely present in the extracellular matrix and certain streptococcic pod membranes of people and vertebrate animal tissues, molecule knot
Structure is the straight chain polymer polysaccharide that n-acetylglucosamine and D-Glucose aldehydic acid dissacharide units repeat composition, average molecular weight
103~107Da.Carboxyl and other polar groups in HA molecule can form hydrogen bond in conjunction with water, and 1 gram of HA can lock its weight
1000 times of water.It is the best substance of the performance of keeping humidity used for cosmetic that finds in current nature, is known as ideal " natural
Moisturizing factor ".
Transdermal fibronectin (Fibronectin, FN) is a kind of protein active object being widely present in human body, is skin
Main non-Collagen glycoprotein in intercellular matrix and basilar memebrane.The monomer composition that FN is 250 kDa by two molecular weight,
There are multiple function fragments.It can closely be tied with substances such as fibrin, heparin, collagen, DNA and cell surface receptors in vivo
It closes.
A good moisturizer can not only increase in short term cuticula water-retaining property, also need guarantee skin that can obtain long-term
It moistens.Therefore, healthy skin state, powerful skin barrier are the premises for guaranteeing the long-term moisturizing of skin.
Erythrothioneine (ergothioneine, EGT), scientific name are 2- sulfydryl-L-Histidine hercynine, a kind of rare
Natural chiral amino acid, be physiological activator important in body.EGT not only has powerful antioxygenic property, may be used also
With maintenance DNA damage, inhibits Apoptosis to react and enhance cell viability.It is produced EGT as Derma-Guard addition moisturizing
Product help to repair and improve skin barrier, promote skin moisturizing benign cycle.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides one kind by hyaluronic acid, transdermal fibronectin and erythrothioneine system
A kind of depth moisturizing compound made of standby, moisturizing significant effect can be used as the water supplement function additive of skin care item.
The present invention solves its technical problem using following technical scheme:
A kind of depth moisturizing compound, the depth moisturizing compound are made of following parts by weight ingredient: hyaluronic acid 0.05 ~ 1
Part, 0.04 ~ 2 part of transdermal fibronectin, 0.06 ~ 4 part of erythrothioneine, 4 ~ 40 parts of dispersing agent, 5 ~ 60 parts of solvent.
As a preferred embodiment, the depth moisturizing compound is made of following parts by weight ingredient: hyaluronic acid 0.1 ~
0.8 part, 0.1 ~ 1 part of transdermal fibronectin, 0.1 ~ 2 part of erythrothioneine, 5 ~ 20 parts of dispersing agent, 6 ~ 40 parts of solvent.
It is made of as one kind most preferably scheme, depth moisturizing compound following parts by weight ingredient: hyaluronic acid 0.5
Part, 1 part of transdermal fibronectin, 0.8 part of erythrothioneine, 6 parts of dispersing agent, 30 parts of solvent.
As a preferred embodiment, the dispersing agent is glycerol.
As a preferred embodiment, the solvent is deionized water.
The present invention also provides a kind of preparation method of depth moisturizing compound, the preparation method of the depth moisturizing compound
Are as follows: it is received according to the ratio with dispersing agent dispersed transparent matter acid and erythrothioneine, is subsequently added to stir in solvent to being completely dissolved, finally
Transdermal fibronectin is added, stirs completely to get the depth moisturizing compound.
Beneficial effects of the present invention: (1) present invention uses natural moisturizing factor hyaluronic acid, not only has excellent moisturizing
Performance, moreover it is possible to which nutrition skin repairs damage, while can also provide the skin sense of lubrication；When transdermal fibronectin being cooperated to be used together,
The permeability that moisturizing factor can be further enhanced realizes the depth moisturizing of skin；Although and the addition of erythrothioneine is to instant
The effect of moisturizing is conducive to repair and improve skin barrier without too big power-assisted, shape healthy skin, allow moisturizing effect more
What is added is long-acting and lasting；(2) it in the present invention, is mutually assisted by three kinds of hyaluronic acid, transdermal fibronectin and erythrothioneine components
It adjusts, realizes deep skin moisturizing；(3) depth moisturizing compound of the present invention can not only realize the depth moisturizing of skin,
Long-time service can also improve skin health state, be a kind of safe and effective moisturizing compound.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described, it is clear that described embodiments are some of the embodiments of the present invention, rather than
Whole embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creative work premise
Under every other embodiment obtained, shall fall within the protection scope of the present invention.
Embodiment 1
A kind of depth moisturizing compound, the depth moisturizing compound are made of following parts by weight ingredient: 0.5 part of hyaluronic acid,
1 part of transdermal fibronectin, 0.8 part of erythrothioneine, 6 parts of dispersing agent, 30 parts of solvent.
The dispersing agent is glycerol.
The solvent is water.
The depth moisturizing compound the preparation method comprises the following steps: being received and ergot sulphur with dispersing agent dispersed transparent matter acid according to the ratio
Cause is subsequently added to be stirred in solvent to being completely dissolved, and is eventually adding transdermal fibronectin, stirs completely to get the depth
Moisturizing compound.
Depth moisturizing compound is added in Essence, the additive amount of depth moisturizing compound is 5%.
Embodiment 2
2 difference from Example 1 of embodiment is raw material proportioning difference, other all identical.
A kind of depth moisturizing compound, the depth moisturizing compound are made of following parts by weight ingredient: hyaluronic acid
0.05 part, 2 parts of transdermal fibronectin, 0.06 part of erythrothioneine, 4 parts of dispersing agent, 60 parts of solvent.
Depth moisturizing compound is added in Essence, the additive amount of depth moisturizing compound is 5%.
Embodiment 3
3 difference from Example 1 of embodiment is raw material proportioning difference, other all identical.
A kind of depth moisturizing compound, the depth moisturizing compound are made of following parts by weight ingredient: hyaluronic acid 1
Part, 0.04 part of transdermal fibronectin, 4 parts of erythrothioneine, 40 parts of dispersing agent, 60 parts of solvent.
Depth moisturizing compound is added in Essence, the additive amount of depth moisturizing compound is 5%.
Comparative example 1
1 difference from Example 1 of comparative example is that raw material composition is different, and comparative example 1 is free of hyaluronic acid.
Comparative example 2
2 difference from Example 1 of comparative example is that raw material composition is different, and comparative example 2 is free of transdermal fibronectin.
Comparative example 3
3 difference from Example 1 of comparative example is that raw material composition is different, and comparative example 3 is free of erythrothioneine.
Comparative example 4
4 difference from Example 1 of comparative example is that raw material composition is different, and comparative example 4 is free of erythrothioneine and hyaluronic acid.
Comparative example 5
5 difference from Example 1 of comparative example is that raw material composition is different, and comparative example 5 is without erythrothioneine and transdermal fine even egg
It is white.
Comparative example 6
6 difference from Example 1 of comparative example is that raw material composition is different, and comparative example 5 is without hyaluronic acid and transdermal fine even egg
It is white.
In order to further prove effect of the invention, following test method is provided:
Human skin moisture content (MMV) test.
Test method: choosing 10 (25 ~ 35 years old) subjects, and men and women is fifty-fifty, and subject dries cleaning with dry face tissue
Face.Measured zone label is carried out in subject or so face after the completion of cleaning.Before official testing, subject is (25 in temperature
± 2 DEG C), humidity is the 30min that sits quietly under 50% ± 2% environment, is not drunk water, and human body holding is loosened.Measure subject 0min,
15min, 30min, 60min, 120min, the moisture content of skin in tested person area and blank district, the test of same group of subject
It is completed by the same survey crew, calculates testing mean, test result is shown in Table 1.
Calculation formula: W%=(W1-W0)/W0*100%, note: w%=skin moisture content increased percentage (MMV), W0
=skin uses moisture content before sample, and W1=skin uses moisture content after sample.
Table 1 human skin moisture content (MMV) experimental test table
As can be seen from Table 1, embodiment 1 is preferred forms, be can be seen that by comparing embodiment 1 with embodiment 2,3, different
Material proportion influences the property of the compound；By comparison comparative example 1 ~ 6 and blank group it is found that hyaluronic acid, transdermal fine even egg
White and these three components of erythrothioneine have synergistic effect, and three kinds of components are mutually coordinated, realize deep skin moisturizing, multiple for this
For closing object, three is indispensable；The compound has remarkable result for improving moisture content of skin.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its
Equivalent defines.
Claims (6)
1. a kind of depth moisturizing compound, which is characterized in that the depth moisturizing compound is made of following parts by weight ingredient: thoroughly
0.05 ~ 1 part of bright matter acid, 0.04 ~ 2 part of transdermal fibronectin, 0.06 ~ 4 part of erythrothioneine, 4 ~ 40 parts of dispersing agent, 5 ~ 60 parts of solvent.
2. depth moisturizing compound according to claim 1, which is characterized in that the depth moisturizing compound is by following heavy
Amount part is at being grouped as: 0.1 ~ 0.8 part of hyaluronic acid, 0.1 ~ 1 part of transdermal fibronectin, 0.1 ~ 2 part of erythrothioneine, dispersing agent 5 ~ 20
Part, 6 ~ 40 parts of solvent.
3. depth moisturizing compound according to claim 1, which is characterized in that the depth moisturizing compound is by following heavy
Amount part is at being grouped as: 0.5 part of hyaluronic acid, 1 part of transdermal fibronectin, 0.8 part of erythrothioneine, 6 parts of dispersing agent, 30 parts of solvent.
4. depth moisturizing compound according to claim 1, which is characterized in that the dispersing agent is glycerol.
5. depth moisturizing compound according to claim 1, which is characterized in that the solvent is deionized water.
6. the preparation method of the described in any item depth moisturizing compounds of claim 1 ~ 5, which is characterized in that the depth moisturizing
Compound the preparation method comprises the following steps: received according to the ratio with dispersing agent dispersed transparent matter acid and erythrothioneine, be subsequently added to stir in solvent
It mixes to being completely dissolved, is eventually adding transdermal fibronectin, stir completely to get the depth moisturizing compound.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910974714.5A CN110522671B (en) | 2019-10-14 | 2019-10-14 | Deep water replenishing compound and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910974714.5A CN110522671B (en) | 2019-10-14 | 2019-10-14 | Deep water replenishing compound and preparation method thereof |
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| Publication Number | Publication Date |
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| CN110522671A true CN110522671A (en) | 2019-12-03 |
| CN110522671B CN110522671B (en) | 2022-06-14 |
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| CN201910974714.5A Active CN110522671B (en) | 2019-10-14 | 2019-10-14 | Deep water replenishing compound and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111568918A (en) * | 2020-06-24 | 2020-08-25 | 华熙生物科技股份有限公司 | Gel composition for treating inflammatory acne and preparation method thereof |
| CN111803397A (en) * | 2020-07-07 | 2020-10-23 | 华熙生物科技股份有限公司 | Scalp care product and preparation method thereof |
| CN112353800A (en) * | 2020-11-10 | 2021-02-12 | 华熙生物科技股份有限公司 | Composition of hyaluronic acid or salt thereof and/or trehalose and use thereof in stabilizing ergothioneine |
| CN114259453A (en) * | 2022-01-20 | 2022-04-01 | 中科东方细胞科技有限公司 | Sensitive muscle relieving and repairing spray and preparation method and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111568918A (en) * | 2020-06-24 | 2020-08-25 | 华熙生物科技股份有限公司 | Gel composition for treating inflammatory acne and preparation method thereof |
| CN111568918B (en) * | 2020-06-24 | 2021-11-16 | 华熙生物科技股份有限公司 | Gel composition for treating inflammatory acne and preparation method thereof |
| CN111803397A (en) * | 2020-07-07 | 2020-10-23 | 华熙生物科技股份有限公司 | Scalp care product and preparation method thereof |
| CN112353800A (en) * | 2020-11-10 | 2021-02-12 | 华熙生物科技股份有限公司 | Composition of hyaluronic acid or salt thereof and/or trehalose and use thereof in stabilizing ergothioneine |
| WO2022100567A1 (en) * | 2020-11-10 | 2022-05-19 | 华熙生物科技股份有限公司 | Use of hyaluronic acid or salt thereof and/or trehalose in stabilizing ergothioneine, and ergothioneine composition containing hyaluronic acid or salt thereof and/or trehalose |
| CN114259453A (en) * | 2022-01-20 | 2022-04-01 | 中科东方细胞科技有限公司 | Sensitive muscle relieving and repairing spray and preparation method and application thereof |
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| CN110522671B (en) | 2022-06-14 |
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