CN111803397B - Scalp care product and preparation method thereof - Google Patents

Abstract

The invention discloses a scalp care product and a preparation method thereof. Through the compounding of the active ingredients, the irritation of salicylic acid and nicotinamide can be effectively relieved, and the skin feeling is mild; the components deeply permeate layer by layer to comprehensively nourish the scalp, greatly reduce the secretion of grease in the deep layer of the skin, realize good oil control effect, effectively improve the moisture content of the scalp, maintain the water-oil balance of the scalp, solve the problems of dry scalp and hair quality damage, and still have good oil control effect after being stopped for a period of time.

Description

Scalp care product and preparation method thereof

Technical Field

The invention relates to a scalp care product and a preparation method thereof, in particular to a scalp care product which has small stimulation and good oil control effect and can maintain the water-oil balance of scalp and a preparation method thereof, belonging to the technical field of daily chemical products.

Background

With the improvement of living standard of people, the head care is more and more emphasized, and scalp problems often appear in the head care, and the scalp problems are mostly caused by factors such as fast living rhythm, night stay, irregular diet, hair scalding and dyeing, environmental pollution and the like and are increasingly prominent. Data from the scalp health research center of the Chinese health education Association show that the scalp of more than 60% of adults in our country have health problems of varying degrees.

The healthy scalp ecosystem is maintained by three major balances: oil, flora and metabolic balance. If the three major balance environments are unbalanced, the scalp is easy to produce oil and become greasy, a large amount of harmful bacteria are bred, and the scalp itch phenomenon appears, and meanwhile, the scalp cuticle metabolism is too fast, and dandruff is easy to form. In addition, the scalp is the second thin skin of the human body and ages 6 times faster than the face. The hair is dried, easy to age and inflame and the like due to wind blowing, solarization, dyeing and scalding, hot air drying and the like, and the hair is also dried, branched and fallen, scales of the hair are damaged, and the hair quality is fragile.

The scalp tissue needs to be assisted to recover and the balance of grease, flora and metabolism is maintained when the healthy scalp state is maintained, at present, commercially available scalp care products are mainly combined with hair care products such as shampoo, hair conditioner and the like, and belong to washing-off products, the residence time of the washing-off products on the scalp is limited, the addition amount of active ingredients is low, so that the scalp care products cannot achieve the real effect, the water-oil balance of the scalp is damaged when the scalp is excessively cleaned, and the scalp sensitivity problem is easily caused. Some hair washing and protecting products improve the problem of scalp grease by adding salicylic acid and the like, for example, patent CN102406553A discloses scalp soothing water which is composed of 95% ethanol, salicylic acid, menthol, essence, modified ketoconazole and deionized water, and can effectively control the oil output of scalp, reduce the generation of dandruff and relieve the pruritus capitis. However, salicylic acid has weak acidity, further stimulates and damages the scalp, causes adverse reactions such as skin allergy, scalp itching and the like, and does not fundamentally solve the scalp problem. Also, for example, patent CN103845264A discloses a scalp care product and a preparation method thereof, the scalp care product is prepared from glycerol, salicylic acid, nicotinamide, edible alcohol, borneol, a rehmannia root extract, allantoin, hyaluronic acid, trimethylglycine, PEG-40 hydrogenated castor oil, essence and water, wherein the water, the glycerol, the salicylic acid, the nicotinamide and the edible alcohol play a role in dissolving redundant oil and restoring water-oil balance, and the combination of the salicylic acid and the nicotinamide can regulate grease secretion of sebaceous glands and accelerate metabolism of skin cuticles. The allantoin, the hyaluronic acid and the trimethylglycine are matched with each other, have a synergistic effect, improve the water locking capacity of the scalp, provide a long-acting moisturizing effect for the scalp and improve the skin irritation tolerance. The product has various components, can adjust water and oil balance by using salicylic acid, nicotinamide and alcohol with high skin irritation, has high alcohol content, has high irritation to skin, and is not suitable for people with sensitive skin or allergic to alcohol. Although allantoin, hyaluronic acid and trimethylglycine are added to improve the moisture-retaining and water-locking capacity of the scalp, the effect of alleviating skin irritation is limited.

Therefore, there is a need for a scalp care product that has good oil control, is non-irritating, and has a mild skin feel.

Disclosure of Invention

In view of this, the invention provides a scalp care composition, which has few components, can effectively relieve scalp oil, inhibit the increase of scalp oil content, effectively improve scalp moisture content, and achieve scalp water-oil balance through the synergistic collocation of the components, and the composition has mild skin feel, is non-irritant, and is available for sensitive people.

The scalp care composition comprises the following components in parts by weight: 0.05-2 parts of hyaluronic acid substances, 1-5 parts of nicotinamide, 0.0001-0.0015 part of ergothioneine and 0.05-2 parts of salicylic acid. The composition can play the above role by matching and combining the four components, and has obvious effect.

Further, in the scalp care composition, the hyaluronic acid-based substance refers to hyaluronic acid and/or a salt thereof, and the hyaluronic acid salt may be various salts acceptable in the medical and cosmetic fields, such as sodium salt, potassium salt, zinc salt, magnesium salt, calcium salt, and the like, and sodium salt is generally used. The hyaluronic acid-like substance may be one or more, and one or more hyaluronic acid salts may be selected.

Furthermore, in the scalp care composition, the hyaluronic acid substances have the functions of increasing the moisture content of the scalp, improving the moisture locking capacity of the scalp, and simultaneously, the hyaluronic acid substances and the ergothioneine are cooperated to reduce the irritation of the salicylic acid and the nicotinamide to the scalp. The hyaluronic acid-like substance has a molecular weight of 0.03 × 10 ⁶ Da～3.0×10 ⁶ Da is selected within the range, the molecular weight of the hyaluronic acid-like substance may be selected from one or more species, and when the molecular weight is selected from more than one species, a combination of a slightly low molecular weight and a slightly high molecular weight is preferably selected.

Preferably, in one embodiment of the present invention, there is provided a method for selecting a hyaluronic acid-based substance, which comprises a high molecular weight hyaluronic acid-based substance and a low molecular weight hyaluronic acid-based substance, wherein the molecular weight of the high molecular weight hyaluronic acid-based substance is 1.0 × 10 ⁶ Da～2.2×10 ⁶ Da, molecular weight of hyaluronic acid substances with low molecular weight of 0.05X 10 ⁶ Da～0.1×10 ⁶ Da. When hyaluronic acid compounds are selected from these two molecular weight ranges, it has better effects of reducing skin irritation and improving water-oil balance of skin when combined with ergothioneine matsutake mushroom extract.

More preferably, the mass ratio of the high molecular weight hyaluronic acid-like substance to the low molecular weight hyaluronic acid-like substance is 1:1 to 3.

Furthermore, ergothioneine (L-Ergothionine, EGT) is chemically named as 2-sulfydryl histidine trimethyl inner salt, is the only known natural 2-thioimidazole amino acid, and is mainly used in cosmetics at present as an antioxidant component and an anti-inflammatory component. According to the invention, through experiments, it is surprisingly found that the irritation of salicylic acid and nicotinamide to the scalp can be well reduced by using the hyaluronic acid substances and the ergothioneine, the oil control capability of the salicylic acid and the nicotinamide can be improved, and the whole moisture content of the scalp can be improved.

At present, many methods for preparing ergothioneine are reported, including a chemical synthesis method, an extraction method and a biological fermentation synthesis method, and the fermentation method is low in cost, convenient for industrial production and the main production method at present. Ergothioneine prepared by various methods can be used in the invention, and the ergothioneine can be in a pure form or in a fermentation solution or an extraction solution. Preferably, the ergothioneine used in the present invention is ergothioneine obtained by fermentation, for example, ergothioneine matsutake mushroom extract produced by the company itself, which is a fermentation liquid obtained by fermentation of matsutake mushroom as a raw material, and contains components such as glucan, polypeptide, amino acid, polysaccharide, etc. in addition to ergothioneine.

Furthermore, when the components of the scalp care composition are selected from the following components in parts by weight, the effect is better: 0.5-1.5 parts of hyaluronic acid substances, 1.5-2.5 parts of nicotinamide, 0.0005-0.001 part of ergothioneine and 0.1-1 part of salicylic acid.

Further, the invention also provides a scalp care product, and the active ingredients of the scalp care product comprise the scalp care composition. In the scalp care product, the weight percentage of each component is as follows: 0.05-2wt% of hyaluronic acid substances, 1-5wt% of nicotinamide, 0.0001-0.0015wt% of ergothioneine and 0.05-2wt% of salicylic acid. Preferably, the content of hyaluronic acid-like substance is 0.5-1.5wt%, the content of nicotinamide is 1.5-2.5wt%, the content of ergothioneine is 0.0005-0.001wt%, and the content of salicylic acid is 0.1-1wt%.

Further, the scalp care product may be various types for scalp care, such as shampoo, shampoo essence, hair mask, etc.

Further, the scalp care product may further include other components, for example, other active ingredients having hair care, hair washing, and hair nourishing effects, such as pH adjusting agents, preservative components, and base components such as water.

In a certain embodiment of the present invention, there is provided a scalp care product consisting of the scalp care composition of the present invention, a pH adjusting agent, a preservative and water, having a pH of 5.0 to 6.0. The pH adjusting agent, the preservative and the amount added are well known in the art and can be selected by those skilled in the art from the prior art.

The invention also provides a preparation method of the scalp care product, which comprises the following steps:

(1) Adding hyaluronic acid substances into water, and stirring until the hyaluronic acid substances are completely dissolved;

(2) Adding nicotinamide, ergothioneine, salicylic acid and a preservative into the mixture obtained in the step (1), and stirring to completely dissolve the nicotinamide, ergothioneine, salicylic acid and preservative;

(3) Adjusting pH range to 5.0-6.0 with pH regulator to obtain scalp care product.

The invention has the following beneficial effects:

1. according to the invention, by compounding the four components, the oil-removing cream can deeply permeate layer by layer, can comprehensively nourish the scalp, can effectively relieve the problems of oil production, pruritus, alopecia and the like of the scalp, greatly reduces the secretion of grease in the deep layer of the skin, realizes a good oil control effect, reduces the risks of dandruff and seborrheic dermatitis, and still has a good oil control effect after being stopped for a period of time.

2. By compounding the four components, the water content of the scalp can be effectively improved, the water-oil balance of the scalp is maintained, and the problem of hair quality damage caused by hair follicles blocked by grease is avoided.

3. The skin-care product has simple components and convenient use, can effectively relieve the irritation of salicylic acid and nicotinamide through the synergistic matching of the components, has mild skin feel, and can be used by sensitive people.

Detailed Description

The following description of exemplary embodiments of the invention, including various details of the embodiments of the invention to facilitate understanding, should be construed as merely illustrative. Accordingly, those of ordinary skill in the art will recognize that various changes and modifications of the embodiments described herein can be made without departing from the scope and spirit of the invention. Also, descriptions of well-known functions and constructions are omitted in the following description for clarity and conciseness.

The experimental methods used in the following examples are all conventional methods unless otherwise specified.

Materials, reagents and the like used in the following examples are commercially available unless otherwise specified.

The hyaluronic acid-based substances used in the following examples were solid powders obtained from Huaxi Biotech Co.

The ergothioneine used in the following examples was an ergothioneine Armillaria matsutake extract having an ergothioneine content of 147mg/L (batch No. 20051131) from Huaxi Biotech Ltd.

Examples 1 to 10

Different scalp care essences were prepared, which consisted of hyaluronic acid-type substances, niacinamide, ergothioneine matsutake mushroom extract, salicylic acid, preservatives, pH adjusting agent and water, and the molecular weights and contents of hyaluronic acid-type substances, niacinamide, ergothioneine matsutake mushroom extract, salicylic acid in scalp care essence were as shown in table 1 below.

TABLE 1 effective components and contents (wt%)

The preparation method comprises the following steps:

1. adding sodium hyaluronate with different molecular weights into a dissolving tank containing water while stirring, and stirring until the sodium hyaluronate is completely dissolved;

2. slowly adding nicotinamide, ergothioneine Armillaria mellea extract, salicylic acid, and antiseptic into the above solution, mixing, and stirring to dissolve completely;

3. adjusting pH to 6.5 with pH regulator to obtain scalp care essence.

Comparative examples 1 to 7

Different scalp care essences are prepared, the scalp care essence consists of effective components, preservatives, pH regulators and water, and the effective components and the content are shown in the following table 2.

Table 2 effective components and contents

The preparation method is the same as above.

Comparative example 8

A scalp care essence comprises sodium hyaluronate, nicotinamide, salicylic acid, allantoin, trimethylglycine, a preservative, a pH regulator and water, wherein the molecular weight of the sodium hyaluronate is 1300Kda, the content of the sodium hyaluronate is 0.9wt%, the content of the nicotinamide is 2.0wt%, the content of the salicylic acid is 0.5wt%, the content of the allantoin is 6.7%, the content of the trimethylglycine is 9wt%, and the pH value is 6.5. The preparation method is the same as above.

Test examples

1. Irritation test

Scalp care essences prepared in examples 1 to 10 and comparative examples 1 to 8 were selected for the test.

Data and grouping of human groups:

1. 90 tested volunteers with healthy skin and no allergic history of skin diseases are 30-50 years old and are randomly divided into 18 groups of 5 persons, and each person randomly tries 2 samples;

2. 45 test volunteers with sensitive muscles, 24-40 years old, with unlimited sex, were randomized into 18 groups of 5 individuals each, and 2 samples were randomized per individual.

The experimental method comprises the following steps: a qualified spot tester is selected, about 0.03mL of scalp care essence sample is dripped into the spot tester in a closed spot-sticking experiment mode, a special adhesive tape for external application is stuck on normal skin of the left forearm and the right forearm of a testee, the skin is stuck once every 24 hours, the patch is uncovered for half an hour, and the recording is carried out according to the standard specified in the table 3. A total of 3 tests were carried out, the results of which are shown in tables 4 and 5.

TABLE 3 identification standards

Grade of	(symbol)	Identification criteria
			0	－	Negative reaction: has no irritation and erythema
1	±	The reaction is carried out deliberately: mild erythema
			2	+	Weak positive reaction: erythema
3	++	Strong positive reaction: erythema, papules, blisters
			4	+++	Extremely strong positive reaction: severe edema and bulla

TABLE 4 90 results of the non-sensitive muscle irritation test

TABLE 5 results of the sensitive muscle irritation test in 45 cases

The results show that, using the scalp care essence of examples 1-10 of the present invention, none of the non-sensitive muscle subjects experienced irritation, few mild irritation in the sensitive muscle subjects, the comparative examples experienced irritation of varying degrees, the comparative example 5 experienced the most severe irritation, and comparative example 8 exhibited a limited effect compared to comparative example 5, although alleviating some of the irritation, indicating that niacinamide and salicylic acid irritated the skin, and that the addition of a proportion of hyaluronic acid and ergothioneine reduced irritation, wherein ergothioneine reduced irritation of niacinamide and salicylic acid better than hyaluronic acid, and the combination of ergothioneine and hyaluronic acid of a certain molecular weight had a significant synergistic effect in reducing irritation of niacinamide and salicylic acid.

2. Oil control effect test

The scalp care essences prepared in examples 1 to 10 and comparative examples 1 to 8 were selected for testing, and scalp oil secretion during use and after a period of non-use was detected, and the instrument used was a skin oil content detector (model Sebumeter SM 815).

Data and grouping of human groups: 90 cases of the volunteers with oily hair and itching are 30-50 years old and have unlimited characters, and are randomly divided into 18 groups of 5 people.

The test environment requires no direct sunlight and no wind; the temperature is 22-24 ℃, and the relative humidity is 40-60%; and (3) dipping a paper towel in clear water, cleaning the cranium tops of the testees, resting for 2 hours to enable the scalps to adapt to the testing environment, respectively smearing the scalp care essences prepared in the examples 1-10 and the comparative examples 1-8 on the cranium top areas of the testees, and naturally drying. The medicine is used once in the morning and at night each day for 30 days, and is stopped after the experiment is finished.

The data before the scalp care essence is used is day 0, 1 time of data acquisition is carried out on days 5, 10, 20 and 30, 1 time of data acquisition is carried out 1 month after the test is finished, the average value of each group of data is obtained, and the test result is shown in table 6.

Table 6 oil control effect test data (unit: a.u.)

The results show that the scalp care essence provided by the invention has an obvious oil control effect, the oil secretion of the scalp is obviously reduced after the scalp care essence is used for 30 days, and the examples still have a good oil control effect 1 month after the test is finished, wherein the oil control effects of examples 3-5 are the best. The comparative example shows the oil control effect in different degrees, but the reduction is lower than that of the example, and the comparative example shows obvious rebound phenomenon after being stopped, so the scalp care essence has better oil control effect and still has the oil control capability after being stopped for a period of time.

3. Test of moisturizing Effect

Scalp care essences prepared in example 4 and comparative examples 1 to 8 were selected for testing.

And (4) carrying out moisturizing efficacy test on the sample according to the light industry standard 'cosmetic moisturizing efficacy evaluation guideline'.

Data and grouping of human groups: 45 volunteers with oily hair and easy itching, 30-50 years old, with unlimited characters, were randomly divided into 9 groups of 5 people each.

The test environment requires no direct sunlight and no wind; the temperature is 22-24 deg.C, relative humidity is 40-60%, before testing, the testee washes hair with the same shampoo, dries, and then keeps a certain body position for 30min. The scalp care essences prepared in example 4 and comparative examples 1 to 8 were applied to the test sites, respectively. When the Corneometer CM825 skin moisture tester is used for measurement, the larger the moisture content value of each experimental part is, the higher the moisture content of the stratum corneum is.

The posterior side of the head was selected as the test site (5 cm. Times.5 cm). The test time points are respectively before sample application (0 min), 30min, 60min and 120min after sample application, and the sample application amount is 2.0 + -0.1 mg/cm ² The rate of increase of the scalp moisture content at different time intervals was calculated, the rate of increase of the scalp moisture content = (moisture content after application-moisture content before application)/moisture content before application × 100%.

The test results are shown in Table 7.

Table 7 moisturizing effect data

The result shows that the scalp care essence prepared by the invention has high moisture content after 2 hours, which shows that the scalp care essence prepared by the invention has good long-acting moisturizing effect. The scalp care essence prepared by using the comparative example has the moisture content increasing rate of the scalp in each time period lower than that of the scalp care essence prepared by using the comparative example 4, and although the moisture content increasing rate of the comparative example in 30min after the scalp care essence is applied is close to that of the scalp care essence prepared by using the comparative example 4, the moisture loss is relatively fast in 60-120min, and the long-acting moisturizing effect is poor, so that the components of the scalp care essence provided by the invention have good synergistic moisturizing and synergistic effects and the long-acting moisturizing effect.

4. Evaluation of Using Effect

The scalp care essence prepared in example 4 and comparative examples 1 to 8 was selected for testing.

Data and grouping of human groups: 45 seborrhoeic dermatitis alopecia patients, 30-50 years old, with unlimited sex, were randomly divided into 9 groups of 5 people each.

After the hair of the testee is washed each time, the scalp care essence is smeared on the scalp, and the scalp is massaged for 5 minutes. After 2 months of use, evaluation was made on the hair loss improvement degree, scalp moistening degree, scalp refreshing degree, scalp acne improvement degree, and hair dryness improvement degree, and the average value was taken for each group, and the test results are shown in table 8.

Evaluation criteria: 1 min-poor, 2 min-poor, 3 min-normal, 4 min-good, 5 min-good.

TABLE 8

The results show that the scalp care essence of example 4 using the present invention has an alopecia improvement degree, a scalp moistening degree, a refreshing degree, a scalp acne improvement degree and a hair dryness improvement degree, which are all significantly superior to the respective proportions. The scalp care essence can be used for moistening scalp, improving alopecia, hair dryness and acne of scalp, is not greasy, and plays a role in scalp care.

While embodiments of the present invention have been described above in connection with what is presently considered to be the most practical and preferred embodiment, the invention is not to be limited to the specific embodiments and applications illustrated and described, which are intended as exemplary, instructional and not as limiting. Those skilled in the art, having the benefit of this disclosure, may effect numerous modifications thereto without departing from the scope of the invention as defined by the appended claims.

Claims (10)

1. The scalp care composition is characterized by comprising the following components in parts by weight: 0.5-2 parts of hyaluronic acid substances, 1-5 parts of nicotinamide, 0.0001-0.0015 part of ergothioneine and 0.05-2 parts of salicylic acid; the hyaluronic acid-like substance is a mixture of high molecular weight hyaluronic acid-like substance and low molecular weight hyaluronic acid-like substance, and the molecular weight of the high molecular weight hyaluronic acid-like substance is 1.0 × 10 ⁶ Da～2.2×10 ⁶ Da, molecular weight of hyaluronic acid substances with low molecular weight of 0.05 × 10 ⁶ Da～0.1×10 ⁶ Da, the mass ratio of the hyaluronic acid substances with the molecular weight to the hyaluronic acid substances with the low molecular weight is 1:1 to 3.

2. A scalp care composition according to claim 1 characterized by comprising the following components in parts by weight: 0.5-1.5 parts of hyaluronic acid substances, 1.5-2.5 parts of nicotinamide, 0.0005-0.001 part of ergothioneine and 0.1-1 part of salicylic acid.

3. A scalp care composition according to claim 1 or 2 characterized by: the hyaluronic acid substance is hyaluronic acid and/or hyaluronate.

4. A scalp care composition according to claim 3 characterized by: the hyaluronic acid salt is selected from one or more of sodium salt, potassium salt, zinc salt, magnesium salt and calcium salt of hyaluronic acid.

5. A scalp care composition according to claim 4 characterized by: the hyaluronate is sodium salt of hyaluronic acid.

6. A scalp care composition according to claim 1 or 2 characterized by: the ergothioneine is extracted from Armillaria mellea, and the ergothioneine is fermentation liquid obtained by fermenting Armillaria mellea as raw material.

7. A scalp care product characterized by: an active ingredient comprising a scalp care composition according to any one of claims 1-6.

8. A scalp care product according to claim 7 wherein: 0.5-2 wt% of hyaluronic acid substances, 1-5wt% of nicotinamide, 0.0001-0.0015wt% of ergothioneine and 0.05-2wt% of salicylic acid.

9. A scalp care product according to claim 7 or 8 wherein: also comprises a pH regulator, a preservative and water.

10. A method of preparing a scalp care product according to claim 7 comprising the steps of:

(1) Adding hyaluronic acid substances into water, and stirring until the hyaluronic acid substances are completely dissolved;

(2) Adding nicotinamide, ergothioneine, salicylic acid and a preservative into the mixture obtained in the step (1), and stirring to completely dissolve the nicotinamide, ergothioneine, salicylic acid and preservative;

(3) Adjusting pH range to 5.0-6.0 with pH regulator to obtain scalp care product.