CN106109265B - A kind of hyaluronic acid moisture-keeping composition and its preparation method and application - Google Patents
A kind of hyaluronic acid moisture-keeping composition and its preparation method and application Download PDFInfo
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- CN106109265B CN106109265B CN201610629293.9A CN201610629293A CN106109265B CN 106109265 B CN106109265 B CN 106109265B CN 201610629293 A CN201610629293 A CN 201610629293A CN 106109265 B CN106109265 B CN 106109265B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The present invention relates to hyaluronic acid technical field, more particularly to a kind of hyaluronic acid moisture-keeping composition, the weight percent of each component is as follows：Molecular weight is the hyaluronic acid or its salt 60 62% of 1100kDa, and molecular weight is the hyaluronic acid or its salt 18 20% of 400kDa, and molecular weight is the hydrolysis hyaluronic acid or its salt 18 20% of 6kDa.Application of the hyaluronic acid moisture-keeping composition in skin cleaning, nursing, cosmetic product.Pass through high and low and scintilla hyaluronic acid reasonable combination, product has the three-dimensional moisture-keeping function of skin holostrome time of skin corium, epidermis, cuticula, skin surface, the instant effect with long-acting moisturizing of product is also gived simultaneously, the glutinous soapy feeling of high molecular weight hyaluronic acid is significantly reduced in skin sense simultaneously, and improves the silk smooth felling of low-molecular-weight hyaluronic acid；It can be used in the cosmetics and cleaning products of form of ownership.
Description
Technical field
The present invention relates to hyaluronic acid technical field, more particularly to a kind of hyaluronic acid moisture-keeping composition further relates to described
The preparation method and application of hyaluronic acid moisture-keeping composition.
Background technology
Hyaluronic acid also known as sodium hyaluronate are a kind of acidic mucopolysaccharides, have excellent lubricity and moisture retention, are known as day
Right moisturizing factor, very universal is applied in cosmetics, is also chased after by consumers in general high.The molecular weight of hyaluronic acid
Distribution is very extensive, and different molecular weight has different physics and chemistry and biological property.High molecular weight hyaluronic acid have water conservation moisturizing, at
The excellent performance of film, lubrication；Middle low-molecular-weight hyaluronic acid can be hydrated cutin-softening layer, promote the supply of skin-nourishing and give up
Object is drained, tender skin.
Currently, the hyaluronic acid overwhelming majority molecular weight added in cosmetics within the scope of 800~1500kDa, belongs to high
Molecular weight ranges.The hyaluronic acid of the molecular weight section has good moisturizing, lubrication and film forming protective effect, the disadvantage is that in skin sense
It is relatively glutinous more greasy on (skin feel), and practical effect is not achieved in when additive amount is very low.Following table summarizes hyaluronic acid not
With relationship when molecular weight and content between moistening effect, skin sense and use cost.
Note：" √ " indicates excellent, can receive；"×" indicates not good enough.
Therefore, a certain molecular weight is applied alone, always there are some defects, and senior middle school's low molecular weight compounds, shared by different molecular weight
Ratio it is also very crucial, a certain ingredient proportion is too high or too low, equally will appear the problems in upper table.Therefore different molecular
Moistening effect and skin sense possessed by ratio and composition shared by the hyaluronic acid of amount need to reach a balance, in balance model
In enclosing, the problems in table could be preferably solved.
What different molecular weight hyaluronic acid was used in mixed way in the prior art records very much, and here is more representative
Several patent applications：
CN 105233270A disclose a kind of pharmaceutical composition for water light treatment, are by high, medium and low, 4 kinds of oligomerization
The hyaluronic acid and collagen of molecular weight, the gel of epidermal growth factor and adjuvant composition.4 kinds of molecular weight are respectively 1300~
2000kDa, 500~1000kDa, 50~300kDa, 3~8kDa, their optimal contents in gel are respectively 0.1%~
0.2%, 0.1%~0.2%, 0.1%~0.5%, 0.2%~0.6%.Improve drying, microgroove, aging by face injection
Equal skin problems.This application is that hyaluronic acid, collagen and epidermal growth factor are delivered directly in skin by injecting
(depth of water optoinjection is usually in skin corium), the improvement for skin problems such as dry skin, microgroove, agings, to a certain degree
The upper effect from injection fillers, by expanding skin volume, and directly replenishing collagen and growth factor, so that
Skin collagen content dramatically increases, and by growth factor to the proliferation function of cell, reaches the effect to resisting age of skin
Fruit has very big difference with use is smeared.
CN 102114031A treat and prevent the hyaluronic acid mixtures of inflammatory bowel disease, contain at least two kinds of molecular weight
Hyaluronic acid, and further contain steroids, immunosuppressor or anti-inflammatory agent etc..The molecular weight of 2 kinds of hyaluronic acids is respectively
1500~5000kDa of high molecular weight (preferably 2000kDa) and 500~1500kDa of low molecular weight (preferably 1000kDa), the two
Ratio is 20：80~80：20, most ratio of greater inequality is 1：1.There is two kinds of molecular weight different rheological characteristics, performance to have both quick-acting and slow
Effect, and play organization bracket and isolation function, by the effect for drugs such as the wound healing effect of stomach and steroids,
Reach therapeutic purposes.The molecular weight of hyaluronic acid, proportioning, purposes and patent of the present invention used in the documents are different.
In the prior art, the technology for reaching more preferable moistening effect is used in combination using different molecular weight hyaluronic acid, grinds
That studies carefully is less, has the space further studied.
Invention content
In order to solve the problems, such as in the above research of hyaluronic acid in the prior art, current inventor provides a kind of hyaluronic acids
Moisture-keeping composition.
The present invention also provides the preparation methods of the hyaluronic acid moisture-keeping composition.
The present inventor additionally provides the application of the hyaluronic acid moisture-keeping composition.
What the present invention was obtained through the following steps：
Functional, safety and stability is the performance of cosmetics indispensability, in addition to this, more actual property
Matter such as applies impression when adherence, glossiness, viscosity use, will directly influence acceptance level of the consumer to product.
The rich experiences that the present inventor during the last ten years accumulates hyaluronic acid research, production and application aspect based on two, and
By the test of the different ratio of different molecular weight in terms of moistening effect and every skin sense, grope to have filtered out one it is best
Balance proportioning so that hyaluronic acid compositions of the present invention not only have relatively good moistening effect, but also have more pleasant skin
Impression, while cosmetics industrial enterprise can also be allowed to receive in cost.
The first aspect of the present invention provides a kind of smooth hyaluronic acid compositions with three-dimensional moisture-keeping efficacy of skin sense.
The hyaluronic acid compositions contain hyaluronic acid or its salt and hydrolysis hyaluronic acid or its salt.By different molecular weight and its
Test of the different ratio in terms of moistening effect and every skin sense gropes to have filtered out a best balance proportioning so that this
Invention hyaluronic acid compositions not only have relatively good moistening effect, but also have more pleasant skin feel, while in cost
Cosmetics industrial enterprise can also be allowed to receive.
The composition contains high and low and scintilla hyaluronic acid (hydrolysis oligomerization hyaluronic acid), and polymer hyaluronic acid exists
Skin surface forms ventilative netted hydration shell, and skin internal moisture is prevented to evaporate, and has instant moistening effect；Low molecule hyalomitome
Acid can be hydrated cutin-softening layer, nourish surface layer；Scintilla hyaluronic acid can be absorbed into skin corium and epidermis with rapid transdermal,
With deep layer water lock ability.Therefore, the present composition passes through high and low and scintilla hyaluronic acid reasonable combination, product tool
There is the three-dimensional moisture-keeping function of skin holostrome time of skin corium, epidermis, cuticula, skin surface, while it is instant to also give product
With the effect of long-acting moisturizing.And digestion oligomerization hyaluronic acid have various bioactivity, such as remove free radical, it is anti-inflammatory,
Anti-aging etc. so that the composition is other than moisturizing or a kind of cosmetic material with multiple biological activities.
A kind of hyaluronic acid moisture-keeping composition, the weight percent of each component are as follows：
Molecular weight is the hyaluronic acid or its salt 60-62% of 1000-1200kDa, and molecular weight is the transparent of 300-500kDa
Matter acid or its salt 18-20%, molecular weight are the hydrolysis hyaluronic acid or its salt 18-20% of 5-7kDa.
It is preferred that the weight percent of each component is as follows：
Molecular weight is the hyaluronic acid or its salt 60-62% of 1100kDa, and molecular weight is the hyaluronic acid or its salt of 400kDa
18-20%, molecular weight are the hydrolysis hyaluronic acid or its salt 18-20% of 6kDa.
It is preferred that the weight percent of each component is as follows：
Molecular weight is the hyaluronic acid or its salt 62% of 1100kDa, and molecular weight is the hyaluronic acid or its salt of 400kDa
18%, molecular weight is the hydrolysis hyaluronic acid or its salt 20% of 6kDa.
The hyaluronic acid moisture-keeping composition, selective hydrolysis hyaluronic acid or its salt are with bacillus A50CGMCC
The digestion oligomerization that the bacillus hyaluronidase that NO.5744 fermented and cultureds obtain degrades to hyaluronic acid or its salt
Hyaluronic acid or its salt.Oligomerization hyaluronic acid can penetrate into corium, improve the lasting moistening effect of skin.Enzyme mentioned in the present invention
It cuts oligomerization hyaluronic acid and hydrolyzes hyaluronic acid, use method disclosed in 102876748 A of CN to obtain, using micro- life
The hyaluronidase that object ferments degrades to high molecular weight hyaluronic acid or its salt, enzyme activity height, mild condition, operation letter
Single, non-environmental-pollution；And obtained digestion oligomerization hyaluronic acid or its salt (HA or) structural integrity.With
The oligomerization hyaluronic acid of other producer's chemical method productions is compared,With percutaneous absorbability is good, purity is high, acellular poison
Property, the advantages that oxidation resistance is strong.Moreover,Different from general hyaluronic acid, it has more bioactivity.
Experiment confirmation,Have the effects that remove free radical, repair cell, sun-proof and Angiogensis after solarization.
The second aspect of the present invention is related to a kind of system of the smooth hyaluronic acid compositions with three-dimensional moisture-keeping efficacy of skin sense
Preparation Method.The preparation method of the hyaluronic acid moisture-keeping composition, it is characterised in that each component is put into mortar and is ground, is mixed
It is even to get.
The third aspect of the present invention further relates to the application of the hyaluronic acid compositions.The hyaluronic acid moisturizing combination
Application of the object in skin cleaning, nursing, cosmetic product.
The hyaluronic acid compositions have three-dimensional moisture-keeping efficacy, while it is saturating in skin sense to significantly reduce high molecular weight
The glutinous soapy feeling of bright matter acid, and improve the silk smooth felling of low-molecular-weight hyaluronic acid；It can be used for cosmetics and the cleaning of form of ownership
In product, including smoothing toner, Essence, gel, lotion, cream, facial mask, color make-up, perfumed soap, facial cleanser and shower cream.
The application, the hyaluronic acid moisture-keeping composition play moisturizing in skin cleaning, nursing, cosmetic product
Effect.
The hyaluronic acid compositions of the present invention, wherein hyaluronate and hydrolysis hyaluronate can be the sodium of hyaluronic acid
Salt, sylvite, magnesium salts, calcium salt or zinc salt；Preferably sodium salt and sylvite are still more preferably sodium salt.
Beneficial effects of the present invention：
1) the composition contains high and low and scintilla hyaluronic acid (hydrolysis oligomerization hyaluronic acid), polymer hyaluronic acid
Ventilative netted hydration shell is formed in skin surface, prevents skin internal moisture from evaporating, there is instant moistening effect；Low molecule is transparent
Matter acid can be hydrated cutin-softening layer, nourish surface layer；Scintilla hyaluronic acid can be absorbed into skin corium and epidermis with rapid transdermal
Layer has deep layer water lock ability.Therefore, the present composition passes through high and low and scintilla hyaluronic acid reasonable combination, product
The three-dimensional moisture-keeping function of skin holostrome time with skin corium, epidermis, cuticula, skin surface, while also giving product i.e.
When and long-acting moisturizing effect.And hydrolysis oligomerization hyaluronic acid has various bioactivity, such as removes free radical, resists
It is scorching, anti-ageing etc. so that the composition is other than moisturizing or a kind of cosmetic material with multiple biological activities.
2) hyaluronic acid compositions described in have three-dimensional moisture-keeping efficacy, while significantly reducing high molecular weight in skin sense
The glutinous soapy feeling of hyaluronic acid, and improve the silk smooth felling of low-molecular-weight hyaluronic acid；It can be used for the cosmetics of form of ownership and clear
In clean product, including smoothing toner, Essence, gel, lotion, cream, facial mask, color make-up, perfumed soap, facial cleanser, shower cream etc..
Description of the drawings
Fig. 1 is the moisture of skin test result of different molecular weight hyaluronic acid composition of sodium,
Fig. 2 is embodiment and the moisture of skin test result of each comparative example composition.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.
The performance of keeping humidity screening of step 1 different molecular weight hyaluronic acid combination
1, sample preparation
Ratio between fixed macromolecule, low molecule and scintilla hyaluronic acid is 6：2：2, compare different molecular weight combination
Performance of keeping humidity.
The preparation of each combined sample：According to the molecular weight combination in table, and respectively according to 6：2：2 ratio weighs, will be every
3 molecular weight hyaluronic acid sodium of kind combination, which are put into mortar, to be fully ground, and after so that it is mixed well, obtains each combined sample.
Using basic moisturizing agent prescription (glycerine 2%, butanediol 2%, water), it is separately added into combination 1~5 sample of combination, is stirred
It mixes and makes it dissolve (concentration of each combined sample in the solution is 0.5%), the sample without Sodium Hyaluronate is as a contrast.Point
The skin moisture content after different samples Ce Shi not be smeared, is combined with this to screen the relatively good molecular weight of moistening effect.
2, moisture of skin test method
Subject age is 22~55 years old, totally 6 people.In 4 × 4cm of right-hand man's inner forearm label2Test area, by 3mg
Sample/cm2Dosage, sample is spread evenly across in trial zone.Moisture of skin tester Corneometer is used respectively
CM825 (Courage+Khazaka companies, Germany) is measured smear before and tested region and blank control when 1h, 3h, 6h after smearing
The moisture content of skin in region.The test of the same subject is completed by the same survey crew.When front and back measurement measurement site and
Indoor temperature and humidity is consistent.
Computational methods：
Test result is shown in Fig. 1.Test result shows under identical conditions of mixture ratios, combine 3 performance of keeping humidity it is best, therefore
It is respectively 1100kDa, 400kDa and 6kDa to select high and low, scintilla Sodium Hyaluronate molecular weight.
Step 2
* it notes：Scintilla hyaluronic acid in comparative example 7 is not to be as obtained by chemical degradation method
Sodium Hyaluronate is weighed according to the ratio shared by each molecular weight of embodiment and comparative example respectively, and according to respective group
Conjunction is put into mortar and is fully ground, it is made to mix well, and obtains embodiment and each comparative example composition sample.
2.1 performance of keeping humidity are tested
It is prepared by test sample：Prepare 0.5% solutionExample and each comparative example respectively, wherein addition qs glycerin and
Pentanediol.Test method is shown in Fig. 2 with the moisture of skin test method in step 1, test result.As can be seen from Figure 2,1 group of embodiment
Moisture of skin increment be above comparative example group, illustrate that the performance of keeping humidity of embodiment group is best.
The sensing examination of 2.2 skins
It is prepared by test sample：Prepare 0.5% solutionExample and each comparative example respectively, wherein addition qs glycerin and
Pentanediol.
Test method：Subject age is 22-55 Sui, totally 10 people.Everyone smears respectively in the back of the hand and arm different parts
Different samples, record impression, and scale is pressed to different test items.Score value is higher, and expression skin sense is poorer, as a result sees below
Table.
The skin sensing test result of table hyaluronic acid compositions (numerical value is average mark in table)
As can be seen from Table 2, every skin sense of embodiment group is preferable, and since high molecular weight is transparent in comparative example
Matter acid proportion is relatively low or higher, thus glutinous soapy feeling, water profit effect and tight feeling etc. all show it is not good enough.Basis simultaneously
Document, the rheological property of its solution changes after the hyaluronic acid mixing of different molecular weight, is not simple superposition behavior.
In conjunction with the moisturizing test result of different molecular weight hyaluronic acid compositions in step 1, embodiment 1,2,3 is finally selected
In molecular weight and proportioning group inventive composition.
Moisture retention test of 1 hyaluronic acid compositions of test example in lotion
The sample of 0.2% embodiment, 1,2,3 composition or 7 composition of comparative example is added in cosmetic emulsion basic components
Product, skin moisture content and skin water loss amount are come the moistening effect of comparative sample after being smeared by measurement.
1. lotion basic components and preparation
Table lotion basic components
Each group sample is prepared according to the conventional fabrication process of lotion.
The moisture retention of lotion is measured according to the method in step 1 using the hyaluronic acid compositions being prepared in step 2,
As a result it see the table below, the lotion performance of keeping humidity of embodiment group hyaluronic acid compositions is substantially better than each comparative example group, in embodiment 2,3
Comprehensive score preferably under the premise of, the moistening effect in lotion basic components still has larger gap with embodiment 1, says
The formula of bright embodiment 1, the moisturizing advantage in lotion basic components are more obvious.And embodiment 1 is the same as the comparison of comparative example 7
As can be seen that the moisture-keeping composition of the hydrolysis hyaluronic acid obtained using different process, moistening effect is also to have very big difference.
The performance of keeping humidity test result of the lotion of table composition containing hyaluronic acid
Moisture retention test of 2 hyaluronic acid compositions of test example in facial mask
Face pack prescription and preparation：
Skin covering of the surface basic components
Facial mask preparation method：Facial mask material is non-woven fabrics, conventionally prepares facial mask liquid, filling to obtain test specimens
Product.
Moisture retention test method：Subject sticks test film sample 20min, other steps are according to the side in test example 1
Method operates, and as a result see the table below, the facial mask performance of keeping humidity of embodiment group hyaluronic acid compositions is substantially better than comparative example group.
The moisture retention test result of the facial mask of table composition containing hyaluronic acid
Therefore, in summary experimental data, hyaluronic acid compositions of the present invention pass through different molecular weight and its different ratio
Test in terms of moistening effect and every skin sense has filtered out and has had both the best of good three-dimensional performance of keeping humidity and skin feel
Ratio is added in lotion, mask and other products, and performance of keeping humidity is also notable.In the comprehensive score preferably premise of embodiment 2,3
Under, the moistening effect in facial mask still has larger gap with embodiment 1, illustrates the formula of embodiment 1, the guarantor in facial mask
Wet advantage is more obvious.And it is transparent that embodiment 1 can be seen that the hydrolysis obtained using different process with the comparison of comparative example 7
The moisture-keeping composition of matter acid, moistening effect are also to have very big difference.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not limited by embodiment
System, other any changes made without departing from the spirit and principles of the present invention, modification, combination, replacement, simplification should be
Equivalence replacement mode, is included within the scope of the present invention.
Claims (7)
1. a kind of hyaluronic acid moisture-keeping composition, it is characterised in that the weight percent of each component is as follows：
Molecular weight is the hyaluronic acid or its salt 60-62% of 1100kDa, and molecular weight is the hyaluronic acid or its salt 18- of 400kDa
20%, molecular weight is the hydrolysis hyaluronic acid or its salt 18-20% of 6kDa.
2. hyaluronic acid moisture-keeping composition according to claim 1, it is characterised in that the weight percent of each component is as follows：
Molecular weight is the hyaluronic acid or its salt 62% of 1100kDa, and molecular weight is the hyaluronic acid or its salt 18% of 400kDa, molecule
Amount is the hydrolysis hyaluronic acid or its salt 20% of 6kDa.
3. hyaluronic acid moisture-keeping composition according to claim 1, it is characterised in that hydrolysis hyaluronic acid or its salt be with
The bacillus hyaluronidase that bacillus A50CGMCC NO.5744 fermented and cultureds obtain carries out hyaluronic acid or its salt
The digestion oligomerization hyaluronic acid or its salt that degradation obtains.
4. the preparation method of the hyaluronic acid moisture-keeping composition described in a kind of any one of claim 1-3, it is characterised in that will
Each component is put into mortar and grinds, mixing to get.
5. the hyaluronic acid moisture-keeping composition described in a kind of any one of claim 1-3 is in skin cleaning, nursing, cosmetic product
In application.
6. application according to claim 5, it is characterised in that skin cleaning, nursing, cosmetic product include smoothing toner, essence
Liquid, gel, lotion, cream, facial mask, color make-up, perfumed soap, facial cleanser and shower cream.
7. application according to claim 5, it is characterised in that the hyaluronic acid moisture-keeping composition is in skin cleaning, shield
Moisture-keeping efficacy is played in reason, cosmetic product.
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