CN109953902B - A method for caring facial skin for non-therapeutic purpose - Google Patents

A method for caring facial skin for non-therapeutic purpose Download PDF

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CN109953902B
CN109953902B CN201910240681.1A CN201910240681A CN109953902B CN 109953902 B CN109953902 B CN 109953902B CN 201910240681 A CN201910240681 A CN 201910240681A CN 109953902 B CN109953902 B CN 109953902B
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skin
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water
moisturizing
agent
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CN109953902A (en
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陈小雪
宫登科
于丽娜
于文超
徐媛媛
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Shandong Zhiyi Intelligent Medicine Biotechnology Co ltd
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Shandong Zhiyi Intelligent Medicine Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method of maintaining facial skin for non-therapeutic purposes comprising the steps of: 1) moisturizing the skin, and 2) locking the skin; the step 1) adopts a skin moisturizing agent for moisturizing treatment, wherein the skin moisturizing agent comprises the following raw materials in percentage by weight: 0.5-4% of allantoin, 0.1-3% of creatine, 1-4% of amino acid humectant, 0.2-1% of low molecular weight hyaluronic acid, 130-1500.1-0.5% of HA, 2-5% of butanediol, the balance of water, 1-4% of pentanediol, 0.1-0.5% of ethyl hexyl glycerol, 1-3% of 24-hour moisturizing factor and 50.5-3% of vitamin B; the step 2) adopts a skin water locking agent for water locking treatment, and the skin water locking agent comprises the following raw materials in percentage by weight: 0.1-0.4% of miniHA, 20-400.05% of HA, 2-6% of butanediol, the balance of water, 2-6% of glycerol, 1-5% of amino acid humectant and 0.6-3.5% of high molecular weight hyaluronic acid.

Description

A method for caring facial skin for non-therapeutic purpose
Technical Field
The invention relates to the field of skin care, in particular to a non-treatment-purpose facial skin care method.
Background
The skin is composed of epidermis, dermis and subcutaneous tissue, and has a thickness of about 0.5-4mm, the skin of face is generally less than 2mm, and the epidermis absorbs nutrition from dermis and subcutaneous tissue and can make cells.
At present, a mode of coating a facial mask is usually adopted for moisturizing the skin, namely, the facial mask is coated on the face for a certain time, and nutritional ingredients in the facial mask enter the facial skin, so that the purpose of moisturizing the facial skin is achieved.
However, there are few steps of water-locking treatment after the mask is applied, and if the effective ingredients in the mask are not locked in time after use, the nutrients in the facial skin are gradually lost and do not play a role of water supplement.
Disclosure of Invention
The technical problem to be solved by the invention is to make up for the defects of the prior art and provide a non-treatment-purpose facial skin care method, which can help the skin to replenish water and lock the water in the skin to achieve the double purposes of replenishing water and locking water.
The technical means of the invention are realized by the following modes:
a method of maintaining facial skin for non-therapeutic purposes comprising the steps of:
1) the water replenishing treatment is carried out on the skin,
2) carrying out water locking treatment on the skin;
the step 1) adopts a skin moisturizing agent for moisturizing treatment, wherein the skin moisturizing agent comprises a component A and a component B, and the component A comprises the following raw materials in percentage by weight: 0.5-4% of allantoin, 0.1-3% of creatine, 1-4% of amino acid humectant, 0.2-1% of low molecular weight hyaluronic acid, 130-1500.1-0.5% of HA, 2-5% of butanediol and the balance of water; the component B comprises the following raw materials in percentage by weight: 1-4% of pentanediol, 0.1-0.5% of ethylhexylglycerin, 1-3% of 24-hour moisturizing factor and 50.5-3% of vitamin B;
the step 2) adopts a skin water locking agent for water locking treatment, the skin water locking agent comprises a component C and a component D, and the component C comprises the following raw materials in percentage by weight: 0.1-0.4% of moisturizing repair component, 0.78-400.01-0.05% of HA20, 0.5% of HA 130-1500.1, 2-6% of butanediol and the balance of water; the component D comprises the following raw materials in percentage by weight: 2-6% of glycerol, 1-5% of amino acid humectant and 78-3% of HA-TL 1000.5.
Further, the low molecular weight hyaluronic acid is prepared from the raw materials miniHA and HA20-40The skin moisturizing agent comprises 0.1-0.5% of miniHA and 0.1-0.5% of HA in percentage by weight of the total weight of the skin moisturizing agent20-40 0.1-0.5%;
The moisturizing and repairing component consists of raw materials of miniHA and ectoine, and the miniHA and the ectoine respectively account for 0.025-0.1% and the ectoine accounts for 0.075-0.3% of the total weight percentage of the skin water locking agent.
Further, the skin moisturizing agent is prepared by adopting the following method:
1) heating purified water to 100 deg.C, boiling to obtain sterile water;
2) adding the raw materials of the component B into a container according to a proportion, and uniformly mixing;
3) adding the raw materials of the component A into a reaction kettle in proportion, and uniformly mixing;
4) adding the sterile water into the component A, stirring until the sterile water is completely dissolved, and uniformly mixing;
5) reducing the temperature of the component A by adopting a cold water cooling method, adding the component B when the temperature is reduced to 45 ℃, and stirring until the components are uniformly mixed;
6) continuously reducing the temperature to 38-40 ℃, and filtering the mixture of the component A and the component B to prepare the skin moisturizing agent;
7) and discharging and filling the skin moisturizing agent to finish the preparation of the skin moisturizing agent.
Further, the skin water-locking agent is prepared by the following method:
1) heating purified water to 100 deg.C, boiling to obtain sterile water;
2) adding the raw materials of the component B into a container according to a proportion, and uniformly mixing;
3) adding the raw materials of the component A into a reaction kettle in proportion, and uniformly mixing;
4) adding the sterile water into the component A, stirring until the sterile water is completely dissolved, and uniformly mixing;
5) reducing the temperature of the component A in the reaction kettle, adding the component B, and stirring until the components are uniformly mixed;
6) continuously reducing the temperature to 45 ℃, and filtering the mixture of the component A and the component B to prepare the skin water locking agent;
7) discharging the skin water locking agent, filling the discharged skin water locking agent into a penicillin bottle, and sealing and storing the penicillin bottle;
8) and sterilizing the penicillin bottle filled with the skin water locking agent by adopting a damp-heat sterilization method to finish the preparation of the skin water locking agent.
Further, the skin moisturizing agent is filled in a mask bag with a mask base cloth.
Further, the time for carrying out the step 1) by using the skin moisturizing agent is 20-30 min.
Further, the preparation processes of the skin moisturizing agent and the skin water locking agent are operated in an aseptic environment, and the preparation time of the skin moisturizing agent and the preparation time of the skin water locking agent are both less than 4 hours.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a non-treatment-purpose facial skin care method which comprises two steps of water replenishing and water locking, wherein in the water replenishing step, hyaluronic acid miniHA and HA with small molecular weight are adopted20-40To perform the water replenishing treatment of the skin, and in the water locking step, hyaluronic acid HA with large molecular weight is adopted130-150And HA-TL100 for skin moisturizing treatment. Due to the difference of molecular weight and the difference of sequential use sequence, the method for caring the face skin can fulfill the aims of moisturizing and locking the skin simultaneously, solves the defect that only moisturizing and water locking are performed in the prior art, and can lock all the nutritional ingredients used in the moisturizing step into the face skin so as to make the nutritional ingredients utilized to the maximum.
In addition, the components used in the water locking step comprise ectoin, so that the components can inhibit sour taste generated by separately adding miniHA for fermentation, increase viscosity and enhance the moisture retention and repair functions in the water locking step.
Detailed Description
The present invention will be further described below based on preferred embodiments.
In addition, the various components on the drawings are enlarged (thick) or reduced (thin) for convenience of understanding, but this is not intended to limit the scope of the present invention.
Singular references also include plural references and vice versa.
The terminology used in the description is for the purpose of describing the embodiments of the invention and is not intended to be limiting of the invention.
The terms first, second, etc. are used herein to distinguish between different elements, but these should not be limited by the order of manufacture, and the names may differ between the detailed description of the invention and the claims.
The invention provides a non-treatment-purpose facial skin care method, which comprises the following steps:
1) the water replenishing treatment is carried out on the skin,
2) and carrying out water locking treatment on the skin.
Wherein, the skin moisturizing agent is adopted in the step 1) for moisturizing treatment, the main component is hyaluronic acid with small molecular weight, and the skin moisturizing agent is adopted in the step 2) for moisturizing treatment, and the main component is hyaluronic acid with large molecular weight.
Preferably, the hyaluronic acid with small molecular weight is prepared from raw material micromolecule hyaluronic acid (miniHA) and hyaluronic acid with small molecular weight (HA)20-40) The hyaluronic acid with high molecular weight consists of hyaluronic acid with high molecular weight (HA) as raw material130-150) And hyaluronic acid cross-linked polymer (HA-TL 100). In step 1), miniHA can penetrate into the subcutaneous tissue, HA20-40The leather extends into the lower part of the dermis to fulfill the aims of deeply moisturizing, moisturizing and repairing; in step 2), HA130-150The HA-TL100 is maintained between the dermis layer and the epidermis layer, and forms a water film outside the epidermis to play a role in long-acting moisture preservation.
The skin water locking agent also comprises a moisturizing repair component, wherein the moisturizing repair component is composed of micromolecule hyaluronic acid (miniHA) and ectoine, and the addition of the ectoine can inhibit sour taste generated by fermentation of the separately added miniHA, increase viscosity and enhance the moisturizing and repair functions in the water locking step.
Preferably, the skin moisturizing agent comprises a component A and a component B, and the skin water-locking agent comprises a component C and a component D.
Wherein the component A comprises the following raw materials in percentage by weight: 0.5-4% of allantoin, 0.1-3% of creatine, 1-4% of amino acid humectant and miniHA 0.1-0.5%、HA20-40 0.1-0.5%、HA130-1500.1-0.5%, 2-5% of butanediol and the balance of water; the component B comprises the following raw materials in percentage by weight: 1-4% of pentanediol, 0.1-0.5% of ethylhexylglycerin, 1-3% of 24-hour moisturizing factor and 50.5-3% of vitamin B; the component C comprises the following raw materials in percentage by weight: miniHA 0.025-0.1%, ectoin 0.075-0.3%, HA20-40 0.01-0.05%、HA130-1500.1-0.5%, 2-6% of butanediol and the balance of water; the component D comprises the following raw materials in percentage by weight: 2-6% of glycerol, 1-5% of amino acid humectant and 78-3% of HA-TL 1000.5.
Wherein, the action effect of each raw material is as follows:
allantoin: promoting tissue growth and cell metabolism, softening stratum corneum protein, protecting from light, sterilizing, preventing corrosion, relieving pain, resisting oxidation, and keeping skin moisture, moistening and softening.
Creatine: the cell energy reserve is increased to strengthen the defense mechanism of skin cells, activate the energy metabolism of cells, stimulate the activity of mitochondria and enhance the synthesis of cell proteins.
Amino acid humectant: can rapidly improve the moisture retention of skin, stimulate cell activity, and has effects of moistening and smoothing skin, and preventing dryness and darkness. Can quickly permeate into skin tissues, so that the skin has the effects of luster, moistening and refreshing.
miniHA: transdermal absorption, deep water replenishing, moisture keeping, antioxidant, antiaging, cell reproduction promoting, and damaged cell repairing.
HA20-40: can penetrate into dermis, has effects of slightly dilating capillary, increasing blood circulation, improving metabolism, promoting skin nutrition absorption, removing wrinkle, increasing skin elasticity, and delaying skin aging.
HA130-150: can form a layer of breathable film on the surface of skin, so that the skin is smooth and moist, the invasion of external bacteria, dust and ultraviolet rays can be blocked, and the skin is protected from being damaged.
Butanediol: the main function of the component is a humectant.
And (3) pentanediol: the humectant has excellent performance, can be used for preparing a preservative-free product, and reduces the allergy caused by the preservative.
Ethyl hexyl glycerol: the emollient and the humectant can improve the moisturizing effect of the formula and have smooth skin feeling.
24-hour moisturizing factor: helping to retain moisture in the epidermis.
Vitamin B5: deeply penetrate and moisturize, stimulate the growth of epithelial cells, promote wound healing, diminish inflammation and repair tissue wounds.
Ectoin: the skin moisturizing cream has excellent moisturizing and water holding capacity, can obviously increase the moisture content of skin, has long-term moisturizing effect, can enhance the skin barrier function of skin immunocompetence, and has good repairing effect on skin with the problems of sunburn, weak cuticle, sensitive skin, damaged skin and the like.
Glycerol: has the functions of moisture retention and moistening, and also has the special effects of high activity, oxidation resistance, alcoholization promotion and the like. HA-TL 100: has compact three-dimensional reticular structure, smooth skin feeling and high elasticity, can form long-acting biological protective film on the surface of skin, and has multiple functions of water locking, water storage, isolation, protection, slow release and the like.
Preferably, the skin moisturizing agent is filled in a mask bag with mask base cloth as mask essence, and the skin water locking agent is filled in a penicillin bottle as stock solution.
The skin moisturizing agent is prepared by the following method:
1) heating purified water to 100 deg.C, boiling to obtain sterile water;
2) adding the raw materials of the component B into a container in proportion, and uniformly mixing;
3) adding the raw materials of the component A into a reaction kettle in proportion, and uniformly mixing;
4) adding sterile water into the component A, stirring until the sterile water is completely dissolved, and uniformly mixing;
5) the temperature of the component A is reduced by adopting a cold water cooling method, when the temperature is reduced to 45 ℃, the component B is added,
stirring to mix evenly;
6) continuously reducing the temperature to 38-40 ℃, filtering the mixture of the component A and the component B, and preparing the skin moisturizing agent;
7) discharging the skin moisturizing agent, and filling into a mask bag with mask base cloth to complete the preparation of the skin moisturizing agent.
The skin water locking agent is prepared by the following method:
1) heating purified water to 100 deg.C, boiling to obtain sterile water;
2) adding the raw materials of the component B into a container in proportion, and uniformly mixing;
3) adding the raw materials of the component A into a reaction kettle in proportion, and uniformly mixing;
4) adding sterile water into the component A, stirring until the sterile water is completely dissolved, and uniformly mixing;
5) reducing the temperature of the component A in the reaction kettle, adding the component B, and stirring until the components are uniformly mixed;
6) continuously reducing the temperature to 45 ℃, filtering the mixture of the component A and the component B, and preparing the skin water locking agent;
7) discharging the skin water locking agent, filling the discharged skin water locking agent into a penicillin bottle, and sealing and storing the penicillin bottle;
8) sterilizing the penicillin bottle filled with the skin water locking agent by adopting a damp-heat sterilization method to finish the preparation of the skin water locking agent.
The preparation processes of the skin moisturizing agent and the skin water locking agent are operated in a sterile environment, and the preparation time of the skin moisturizing agent and the preparation time of the skin water locking agent are both less than 4 hours, so that the generation of bacteria during preparation is prevented.
When the skin moisturizing agent is prepared, in the step 8), a damp-heat sterilization method is adopted for sterilization, and specifically, the skin moisturizing agent can be sterilized in a damp-heat sterilization cabinet by standing at a high temperature of 121 ℃ for 10 minutes.
Meanwhile, the skin water locking agent also comprises a moisturizing and repairing component consisting of micromolecule hyaluronic acid (miniHA) and ectoine, and the addition of the ectoine can inhibit sour taste generated by fermentation of separately added miniHA, increase viscosity and enhance the moisturizing and repairing functions in the water locking step.
In order to find the optimal proportioning of the moisture-preserving and repairing components, a plurality of groups of skin moisture-preserving and repairing agents are prepared according to the proportioning of micromolecular hyaluronic acid (miniHA) and ectoin in the following table and the method, the optimal proportioning of the moisture-preserving and repairing components is found, meanwhile, the water content of the prepared skin moisture-preserving and repairing agents is tested, and the proportioning process and the result are shown in the following table 1.
Table 1:
Figure BDA0002009023090000071
Figure BDA0002009023090000081
as can be seen from table 1 above, when the miniHA and ectoine are respectively blended in the ratio of miniHA 0.05% and ectoine 0.15% by weight, the prepared skin-moisturizing agent has no fermented acidic taste, and the water content of the skin-moisturizing agent is relatively high, thereby ensuring the moisturizing and repairing effects of the skin-moisturizing agent.
The method for caring facial skin, which is not intended for treatment, according to the present invention will be described in detail with reference to the following examples.
Examples
1) Skin moisturizing treatment: cleaning face, uniformly applying facial mask containing skin moisturizing agent on face, maintaining for 30min, taking off the applied facial mask, and washing face with clear water;
2) water locking treatment of skin: cleaning face, and uniformly applying the skin water-locking agent on face.
Comparative example 1
Only the step 1) of cleaning the face is carried out, the face mask containing the skin moisturizing agent is uniformly applied on the face and kept for 30min, and after the time is up, the applied face mask is taken down and washed by clean water.
Comparative example 2
Only step 2) is carried out, namely, the face is cleaned, and the skin water-locking agent is uniformly coated on the face.
Comparative example 3
Simultaneously performing the steps 1) and 2), namely cleaning the face, uniformly applying the facial mask containing the skin moisturizing agent on the face, and uniformly applying the skin water-locking agent on the face for 30 min.
100 office workers (female, age 20-50 years) are selected for testing, the test is divided into four groups, each group comprises 25 persons, the operation test is respectively carried out according to the example, the comparative example 1, the comparative example 2 and the comparative example 3, the skin improvement condition of the test subject is scored by a sensory evaluation method after the test is finished, the score is 5, 1 is the worst, 3 is moderate, 5 is the best, the implementation mode adopted by the corresponding test subject is the better when the score is higher, and the evaluation result of the test subject is shown in table 2 after the test is finished.
Table 2:
detailed description of the preferred embodiments Water supplement situation Water lock condition Comprehensive results
Examples 5 4 4.5
Comparative example 1 4 3 3.5
Comparative example 2 2 4 3
Comparative example 3 1 2 1.5
As can be seen from table 2, the embodiment adopted in the examples has better moisturizing and water-locking effects, and thus it can be seen that the non-therapeutic facial skin care method provided by the present invention can achieve better moisturizing and water-locking effects.
While the invention has been described in detail and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that various changes and modifications can be made therein without departing from the spirit of the invention, and it is intended to claim all such changes and modifications as fall within the scope of the appended claims.

Claims (6)

1. A method of maintaining facial skin for non-therapeutic purposes, comprising the steps of:
1) the water replenishing treatment is carried out on the skin,
2) carrying out water locking treatment on the skin;
the step 1) adopts a skin moisturizing agent for moisturizing treatment, wherein the skin moisturizing agent comprises a component A and a component B, and the component A comprises the following raw materials in percentage by weight: 0.5-4% of allantoin, 0.1-3% of creatine, 1-4% of amino acid humectant, 0.2-1% of low molecular weight hyaluronic acid and HA130-1500.1-0.5%, 2-5% of butanediol and the balance of water; the component B comprises the following raw materials in percentage by weight: 1-4% of pentanediol, 0.1-0.5% of ethylhexylglycerin, 1-3% of 24-hour moisturizing factor and 50.5-3% of vitamin B; the step 2) adopts a skin water locking agent for water locking treatment, and the skin water locking agent comprises a component C and a component DThe component C comprises the following raw materials in percentage by weight: 0.1-0.4% of moisturizing and repairing component and HA20-40 0.01-0.05%、HA130-1500.1-0.5%, 2-6% of butanediol and the balance of water; the component D comprises the following raw materials in percentage by weight: 2-6% of glycerol, 1-5% of amino acid humectant and 78-3% of HA-TL 1000.5;
the moisturizing and repairing component consists of raw materials of miniHA and ectoine, the miniHA and the ectoine are respectively 0.05 percent and 0.15 percent in percentage by weight of the total skin water locking agent, the addition of the ectoine can inhibit sour taste generated by separately adding miniHA for fermentation, increase viscosity, and simultaneously enhance the moisturizing and repairing functions in the water locking step;
the low molecular weight hyaluronic acid is prepared from raw materials miniHA and HA20-40The skin moisturizing agent comprises 0.1-0.5% of miniHA and 0.1-0.5% of HA in percentage by weight of the total weight of the skin moisturizing agent20-40 0.1-0.5%。
2. A method of maintaining facial skin for non-therapeutic purposes according to claim 1 wherein the skin moisturizing agent is prepared by:
1) heating purified water to 100 deg.C, boiling to obtain sterile water;
2) adding the raw materials of the component B into a container according to a proportion, and uniformly mixing;
3) adding the raw materials of the component A into a reaction kettle in proportion, and uniformly mixing;
4) adding the sterile water into the component A, stirring until the sterile water is completely dissolved, and uniformly mixing;
5) reducing the temperature of the component A by adopting a cold water cooling method, adding the component B when the temperature is reduced to 45 ℃, and stirring until the components are uniformly mixed;
6) continuously reducing the temperature to 38-40 ℃, and filtering the mixture of the component A and the component B to prepare the skin moisturizing agent;
7) and discharging and filling the skin moisturizing agent to finish the preparation of the skin moisturizing agent.
3. A method of maintaining facial skin for non-therapeutic purposes as in claim 1 wherein the skin lock is prepared by the method of:
1) heating purified water to 100 deg.C, boiling to obtain sterile water;
2) adding the raw materials of the component D into a container in proportion, and uniformly mixing;
3) adding the raw materials of the component C into a reaction kettle in proportion, and uniformly mixing;
4) adding the sterile water into the component C, stirring until the sterile water is completely dissolved, and uniformly mixing;
5) reducing the temperature of the component C in the reaction kettle, adding the component D, and stirring until the components are uniformly mixed;
6) continuously reducing the temperature to 45 ℃, and filtering the mixture of the component C and the component D to prepare the skin water locking agent;
7) discharging the skin water locking agent, filling the discharged skin water locking agent into a penicillin bottle, and sealing and storing the penicillin bottle;
8) and sterilizing the penicillin bottle filled with the skin water locking agent by adopting a damp-heat sterilization method to finish the preparation of the skin water locking agent.
4. A method of non-therapeutic facial skin care as in claim 2 wherein said skin hydrating agent is potted in a mask pack having a mask base cloth.
5. A method of maintaining facial skin for non-therapeutic purposes as recited in claim 1 wherein the step 1) is performed with the skin moisturizer for a period of time ranging from 20 minutes to 30 minutes.
6. A method of non-therapeutic facial skin care according to any of claims 2 or 3, wherein said skin moisturizer and said skin lock are prepared in a sterile environment and are prepared in less than 4 hours.
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WO2012051681A1 (en) * 2010-10-22 2012-04-26 Wiezorkoski Antonio Carlos Cosmetic composition for a protective isolating film which is topically applied to the region of the eponychium and periungual fold of the finger
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