CN108158843A - It is a kind of can the sodium hyaluronate stoste and preparation method thereof that imports of micropin - Google Patents
It is a kind of can the sodium hyaluronate stoste and preparation method thereof that imports of micropin Download PDFInfo
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- CN108158843A CN108158843A CN201711421217.XA CN201711421217A CN108158843A CN 108158843 A CN108158843 A CN 108158843A CN 201711421217 A CN201711421217 A CN 201711421217A CN 108158843 A CN108158843 A CN 108158843A
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- sodium hyaluronate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention belongs to technical field of fine, be related to it is a kind of can the sodium hyaluronate stoste that imports of micropin and preparation method thereof, including sub-Q, low molecule sodium hyaluronate, oligomerization sodium hyaluronate and thickener, glycerine, butanediol and 1,2 pentanediols, water for injection；Preparation method is water for injection, 1,2 pentanediols and thickener are added sequentially in emulsification pot, cooling, stirring is extremely dissolved, pot temperature to be emulsified is down to 65 DEG C 75 DEG C, sequentially adds glycerine, butanediol, sub-Q, low molecule sodium hyaluronate and oligomerization sodium hyaluronate, pot to be emulsified are cooled to 30 DEG C 35 DEG C, obtain sodium hyaluronate stoste.The present invention can micropin import sodium hyaluronate stoste is safe, effect is good, give dry skin instant moisturizing, realize that three-dimensional moisturizing also contributes to improve simultaneously the soft appropriateness of skin, dry line, microgroove caused by reducing water shortage, and it can prevent and repair skin injury, restore water profit gloss and full elasticity promotes the absorption of other active materials, delay skin aging.
Description
Technical field
The invention belongs to technical field of fine, are related to a kind of skin care item and preparation method thereof, and specially one kind can be micro-
Sodium hyaluronate stoste that needle imports and preparation method thereof.
Background technology
Sodium hyaluronate, also known as hyaluronic acid (HA) are the intrinsic biological substances of skin, contain in human epidermal and corium
HA, amount account for more than half of human body HA, and with age, skin aging, HA contents decline in skin, skin tissue cell and
Intercellular moisture reduces, and the water content of skin is directly related with the content of HA, the glue formed based on hyaluronic acid
The space that dress matrix is filled is reduced, and causes cell arrangement close, and collagen dehydration hardening, skin becomes coarse, loses bullet
Then there is wrinkle in property.It is true that human skin is entered using Sodium Hyaluronate as the hyaluronic acid sodium gel that primary raw material researchs and develops
Skin shallow-layer can keep the moisture in skin, promote the supply of nutriment and the excretion of unwanted metabolite object.Epidermal cell is promoted to increase
It grows and breaks up and scavenging activated oxygen, so as to prevent skin aging, play the role of beauty and beauty treatment.
Micropin (microneedle) generally refers to tip diameter at tens microns hereinafter, length is less than one to two millimeter
Micro needle head.The principle of micropin beauty is using many small syringe needles on micropin, stimulates skin, micropin can within a very short time
It is more than millions of a microtubules to make, active constituent is enabled effectively to penetrate into skin, anti-wrinkle is equipped with, whitening, repairs, gestation of dispelling
The special efficacys product such as line, scar eliminating, so as to reach subtract light wrinkle, treatment scar and striae of pregnancy, skin whitening, subtract light color spot, improve
The ideal effects such as eye wrinkle-removing, livid ring around eye, tightening and promotion skin of face tissue.Sodium hyaluronate is glued with the increase of molecular weight
Degree increase, it more difficult to pass through gap caused by micropin, it is difficult to the good injection of sodium hyaluronate is realized using micropin beauty.
At present, due to cost and technology, it is still the sodium hyaluronate of macromolecular that many products are most commonly used, containing only
The skin care item effect for having unimodal molecular weight sodium hyaluronate is limited, and is difficult to realize the good injection of sodium hyaluronate using micropin beauty, and
The best cosmetology effect of sodium hyaluronate cannot be played.
Invention content
One of the objects of the present invention is to provide it is a kind of can micropin import sodium hyaluronate stoste, can realize micropin import skin
Skin solves dry skin water shortage problem from inside to outside；
The second object of the present invention be to provide it is a kind of can the preparation method of sodium hyaluronate stoste that imports of micropin, overcome difference
The miscible technical barrier of molecular weight sodium hyaluronate.
The technical scheme is that：It is a kind of can micropin import sodium hyaluronate stoste, by weight, successively include it is as follows
Ingredient：
The features of the present invention also characterized in that：
The molecular weight of sub-Q is not less than 1000kDa；The molecular weight of low molecule sodium hyaluronate is 10kDa-1000kDa
Between.
The molecular weight ＜ 10kDa of oligomerization sodium hyaluronate.
Thickener is xanthan gum.
Another technical solution of the present invention is, can the preparation method of sodium hyaluronate stoste that imports of micropin, successively
Include the following steps：
Step 1) weighs water for injection, is added in emulsification pot, sequentially adds load weighted 1,2- pentanediols and thickener,
Cooling is opened, stirring is to being completely dissolved；
Step 2) pot temperature to be emulsified is down to 65 DEG C -75 DEG C, sequentially adds load weighted glycerine, butanediol, macromolecular glass
Uric acid, low molecule sodium hyaluronate and oligomerization sodium hyaluronate, stirring is to being completely dissolved；
Step 3) pot to be emulsified is cooled to 30 DEG C -35 DEG C, obtains sodium hyaluronate stoste；
Step 4) is filling by step 3 gained sodium hyaluronate stoste, moist heat sterilization to get to it is sterile can the glass urine that imports of micropin
Sour stoste.
In step 1)：Thickener is xanthan gum.
In step 2)：The molecular weight of sub-Q is not less than 1000kDa；The molecular weight of low molecule sodium hyaluronate is
Between 10kDa-1000kDa, the molecular weight ＜ 10kDa of oligomerization sodium hyaluronate.
Pot is emulsified using the complete emulsifying devices of Fu Luke, unit type FISCO-10L.
In step 4)：Moist heat sterilization temperature is 110 DEG C -130 DEG C, sterilization time 6min-10min.
The technique effect of the present invention：
(1) it is of the invention it is a kind of can the sodium hyaluronate stoste that imports of micropin, with the sodium hyaluronate of three kinds of molecular weight, macromolecular glass
Uric acid molecular weight is not less than 1000kDa, has excellent moisture retention, lubricity, film forming and stabilization, and can obstruct external
The intrusion of dust, ultraviolet light protects the skin from encroaching on；Low molecule sodium hyaluronate molecular weight is between 10kDa-1000kDa, nutrition
Skin, lasting moisturizing；Oligomerization sodium hyaluronate molecular weight ＜ 10kDa, can Transdermal absorption, deep moisturizing, after-sun improves new old
Metabolism promotes skin-nourishing absorption, increases skin elasticity, delay skin aging；
(2) sodium hyaluronate stoste of the invention not only solves the drying of skin surface water shortage, forms ventilated membrane, more can quickly ooze
Thoroughly, improve itself moisturizing and water lock ability from flesh bottom, dry line caused by promoting the proliferation of epidermal cell and differentiation, reduction water shortage,
Microgroove, and can prevent and repair skin injury, restore gloss elasticity；Can intelligence be changed according to external environment humidity and adjust skin institute
Need appropriate moisture；The micropin of product cooperation simultaneously uses, and plays moisturizing repair to skin different levels, makes product efficacy more preferable
It plays；
(3) it is of the invention it is a kind of can the preparation method of sodium hyaluronate stoste that imports of micropin, by the sodium hyaluronate of three kinds of molecular weight,
That is sub-Q, low molecule sodium hyaluronate and the mixing of oligomerization sodium hyaluronate, it is homogeneous, there is higher stability, no layering
Without precipitation.
Specific embodiment
The present invention is described in detail With reference to embodiment.
The technical solution adopted in the present invention is, it is a kind of can the sodium hyaluronate stoste that imports of micropin, by weight, wrap successively
Include following ingredient：
Wherein, the molecular weight of sub-Q is not less than 1000kDa, forms elastic moisture film in skin surface, prevents
Moisture loss resists extraneous invasion；
The molecular weight of low molecule sodium hyaluronate has mild dilation capillary between 10kDa-1000kDa, increases blood
Cycle improves intermediate supersession, promotes skin-nourishing absorption, has the function of stronger wrinkle-chasing, can increase skin elasticity, delay
Skin aging；
The molecule L T.LT.LT 10kDa of oligomerization sodium hyaluronate, are permeable to skin base layer, moreover it is possible to promote the proliferation of epidermal cell and divide
Change, scavenging activated oxygen, can prevent and repair skin injury；
Thickener is xanthan gum.
The present invention can micropin import sodium hyaluronate stoste preparation method, in turn include the following steps：
Step 1) weighs the following raw material by weight：Water for injection, 1,2- pentanediol 0.1%-5.8% and thickener
0.05%-1.0% is added sequentially in emulsification pot, opens cooling, stirring is to being completely dissolved；
Step 2) weighs the following raw material by weight：Glycerine 1.0%-10.0%, butanediol 0.1%-6.0%, big point
Sub- sodium hyaluronate 0.01%-1.0%, low molecule sodium hyaluronate 0.01%-1.0% and oligomerization sodium hyaluronate 0.01%-1.0%；
Pot temperature to be emulsified is down to 65 DEG C -75 DEG C, sequentially adds load weighted glycerine, butanediol, sub-Q, low
Molecule sodium hyaluronate and oligomerization sodium hyaluronate, stirring is to being completely dissolved；
Step 3) pot to be emulsified is cooled to 30 DEG C -35 DEG C, obtains sodium hyaluronate stoste；
Step 4) is filling by step 3 gained sodium hyaluronate stoste, and moist heat sterilization, moist heat sterilization temperature is 110 DEG C -130 DEG C, is gone out
The bacterium time for 6min-10min to get to it is sterile can the sodium hyaluronate stoste that imports of micropin.
Embodiment 1
Prepare can micropin import sodium hyaluronate stoste：
Step 1) weighs the following raw material by weight：
Step 1) is weighed water for injection, 1,2- pentanediols and the thickener of gained by step 2), is added sequentially to emulsification pot
In, cooling, stirring is to being completely dissolved；
Step 3) pot temperature to be emulsified is down to 65 DEG C, sequentially adds glycerine, butanediol, macromolecular that step 1) weighs gained
Sodium hyaluronate, low molecule sodium hyaluronate and oligomerization sodium hyaluronate, stirring is to being completely dissolved；
Step 4) pot to be emulsified is cooled to 30 DEG C, obtains sodium hyaluronate stoste；
Step 4) is filling by step 3 gained sodium hyaluronate stoste, and moist heat sterilization, moist heat sterilization temperature is 110 DEG C, sterilization time
For 10min to get to it is sterile can the sodium hyaluronate stoste that imports of micropin.
The present embodiment can micropin import sodium hyaluronate stoste, mass concentration 10mg/ml, pH 6.9.
Embodiment 2
Prepare can micropin import sodium hyaluronate stoste：
Step 1) weighs the following raw material by weight：
Step 1) is weighed water for injection, 1,2- pentanediols and the thickener of gained by step 2), is added sequentially to emulsification pot
In, cooling is opened, stirring is to being completely dissolved；
Step 3) pot temperature to be emulsified is down to 70 DEG C, sequentially adds glycerine, butanediol, macromolecular that step 1) weighs gained
Sodium hyaluronate, low molecule sodium hyaluronate and oligomerization sodium hyaluronate, stirring is to being completely dissolved；
Step 4) pot to be emulsified is cooled to 33 DEG C, obtains sodium hyaluronate stoste；
Step 4) is filling by step 3 gained sodium hyaluronate stoste, and moist heat sterilization, moist heat sterilization temperature is 120 DEG C, sterilization time
For 7min to get to it is sterile can the sodium hyaluronate stoste that imports of micropin.
The present embodiment can micropin import sodium hyaluronate stoste, mass concentration 11mg/ml, pH 6.8.
Embodiment 3
Prepare can micropin import sodium hyaluronate stoste：
Step 1) weighs the following raw material by weight：
Step 1) is weighed water for injection, 1,2- pentanediols and the thickener of gained by step 2), is added sequentially to emulsification pot
In, cooling is opened, stirring is to being completely dissolved；
Step 3) pot temperature to be emulsified is down to 75 DEG C, sequentially adds glycerine, butanediol, macromolecular that step 1) weighs gained
Sodium hyaluronate, low molecule sodium hyaluronate and oligomerization sodium hyaluronate, stirring is to being completely dissolved；
Step 4) pot to be emulsified is cooled to 35 DEG C, obtains sodium hyaluronate stoste；
Step 5) is filling by step 3 gained sodium hyaluronate stoste, and moist heat sterilization, moist heat sterilization temperature is 130 DEG C, sterilization time
For 6min to get to it is sterile can the sodium hyaluronate stoste that imports of micropin.
The present embodiment can micropin import sodium hyaluronate stoste, mass concentration 11mg/ml, pH 7.0.
The homogenizer used in the present embodiment is：The not complete emulsifying device of Luke, unit type FISCO-10L.
To obtained by the present embodiment can micropin import sodium hyaluronate stoste, carried out stability, security test, result
It is as follows：
1. stability test
Example 1-3 prepare gained can the sodium hyaluronate stoste that imports of micropin, be placed in 40 DEG C, in RH20% environment, inspection
The character of preparation, the content of active ingredient, acid-base value, viscosity have unchanged under survey acceleration environment, and stability data is shown in Table 1.
1 stability test result of table
It was tested through six months it is found that stoste appearance, HA contents, pH, viscosity and fungus resistance prepared by embodiment 1-3 can be without bright
Aobvious variation, therefore can also speculate 24 months stabilizations of preparation at room temperature.
2. Skin stimulant experiment in Rabbit
Purpose：Using rabbit as subjects, carry out Skin Irritation Test research, investigate can micropin import sodium hyaluronate stoste
The potential of stimulate the reaction is generated under test conditions.
Sample：Embodiment 1 prepares gained can the sodium hyaluronate bulk samples of micropin importing and the sterile saline of reference examples.
Animal：Healthy new zealand white rabbit 3.
Experimental implementation：Sodium hyaluronate bulk samples single is in direct contact the skin of rabbit backbone both sides for 24 hours, by the same method of gauze piece
Contact is as control.(24 ± 2) h, (48 ± 2) h, (72 ± 2) h, score to contact site erythema, oedema, and count after contact
Calculate primary stimulus index (P II).
Evaluation index：Standards of grading are carried out by table 2.
2 dermoreaction scoring criteria of table
Result of the test is as shown in table 3：
3 skin irritation test result of table
Note：ER：Erythema；ED：Oedema.
Primary stimulus index (P II)=0.0.
It follows that under this experimental condition, which is 0.3. skin
Water content is tested
Example 1-3 prepare gained can micropin import sodium hyaluronate stoste, respectively micropin import after, use moisture of skin
Analyzer, which measures, imports front and rear skin moisture content variation, the results are shown in Table 4.
4 moisture content of skin test result of table
| Group | Water content % before importing | 1 hour water content % after importing | 4 hours water content % after importing |
| Embodiment 1 | 37±5 | 62±7 | 51±2 |
| Embodiment 2 | 42±4 | 67±5 | 54±6 |
| Embodiment 3 | 34±7 | 66±6 | 56±3 |
The result shows that the moisture content of skin of embodiment 1-3 is higher.
4. skin elasticity
The scoring of Fitzpatrick skin elasticities is also best for 1 point, and 9 points worst, and test result is shown in Table 5.
5 skin elasticity test result of table
| Group | Skin elasticity scores before importing | Import skin elasticity scoring |
| Embodiment 1 | 4.6±0.5 | 3.1±0.5 |
| Embodiment 2 | 4.0±0.3 | 3.2±0.2 |
| Embodiment 3 | 4.2±0.6 | 3.0±0.6 |
As shown in Table 5, skin elasticity scoring has significant change after micropin has imported the stoste of embodiment 1-3, illustrates to implement
Stoste energy bright color and improve skin elasticity performance prepared by example 1-3.
From the point of view of the skin elasticity result of subject human test, especially with the more small molecule sodium hyaluronates of addition
The skin of face elasticity of subject significantly improves, and skin becomes soft and smooth delicacy.
The present invention it is a kind of can the sodium hyaluronate stoste that imports of micropin, with the sodium hyaluronate of three kinds of molecular weight, macromolecular glass urine
Acid molecule amount is not less than 1000kDa, has excellent moisture retention, lubricity, film forming and stabilization, and can obstruct external ash
The intrusion of dirt, ultraviolet light protects the skin from encroaching on；Low molecule sodium hyaluronate molecular weight is between 10kDa-1000kDa, nutrition flesh
Skin, lasting moisturizing；Oligomerization sodium hyaluronate molecular weight ＜ 10kDa, can Transdermal absorption, deep moisturizing, after-sun improves new old generation
It thanks, promotes skin-nourishing absorption, increase skin elasticity, delay skin aging；The sodium hyaluronate stoste of the present invention not only solves
Skin surface water shortage is dried, and forms ventilated membrane, more can rapid osmotic, improve itself moisturizing and water lock ability from flesh bottom, promote table
The proliferation of chrotoplast and differentiation reduce dry line, microgroove caused by water shortage, and can prevent and repair skin injury, restore gloss bullet
Property；Appropriate moisture needed for intelligence adjusting skin can be changed according to external environment humidity；The micropin of product cooperation simultaneously uses, to skin
Different levels play moisturizing repair, and product efficacy is made more preferably to play；The present invention it is a kind of can the sodium hyaluronate that imports of micropin it is former
The preparation method of liquid, by the sodium hyaluronate of three kinds of molecular weight, i.e. sub-Q, low molecule sodium hyaluronate and oligomerization sodium hyaluronate mixes
It closes, it is homogeneous, there is higher stability, no layering is without precipitation.
Claims (9)
1. it is a kind of can micropin import sodium hyaluronate stoste, by weight, successively including following ingredient：
Sub-Q 0.01%-1.0%
Low molecule sodium hyaluronate 0.01%-1.0%
Oligomerization sodium hyaluronate 0.01%-1.0%
Thickener 0.05%-1.0%
Glycerine 1.0%-10.0%
Butanediol 0.1%-6.0%
1,2- pentanediol 0.1%-5.8%
Water for injection surplus.
2. it is as described in claim 1 it is a kind of can the sodium hyaluronate stoste that imports of micropin, it is characterised in that：The sub-Q
Molecular weight be not less than 1000kDa；The molecular weight of low molecule sodium hyaluronate is between 10kDa-1000kDa.
3. it is as described in claim 1 it is a kind of can the sodium hyaluronate stoste that imports of micropin, it is characterised in that：The oligomerization sodium hyaluronate
10 kDa of molecular weight ＜.
4. it is as described in claim 1 it is a kind of can the sodium hyaluronate stoste that imports of micropin, it is characterised in that：The thickener is given birth to for the Chinese
Glue.
5. it is a kind of can micropin import sodium hyaluronate stoste preparation method, in turn include the following steps：
Step 1）Water for injection is weighed, is added in emulsification pot, sequentially adds load weighted 1,2- pentanediols and thickener, open
Cooling, stirring is to being completely dissolved；
Step 2）Pot temperature to be emulsified is down to 65 DEG C -75 DEG C, sequentially add load weighted glycerine, butanediol, sub-Q,
Low molecule sodium hyaluronate and oligomerization sodium hyaluronate, stirring is to being completely dissolved；
Step 3）Pot to be emulsified is cooled to 30 DEG C -35 DEG C, obtains sodium hyaluronate stoste；
Step 4）Step 3 gained sodium hyaluronate stoste is filling, moist heat sterilization to get to it is sterile can the sodium hyaluronate that imports of micropin it is former
Liquid.
6. it is as claimed in claim 5 it is a kind of can the preparation method of sodium hyaluronate stoste that imports of micropin, it is characterised in that：Step 1）
Described in thickener be xanthan gum.
7. it is as claimed in claim 5 it is a kind of can the preparation method of sodium hyaluronate stoste that imports of micropin, it is characterised in that：Step 2）
Described in sub-Q molecular weight be not less than 1000kDa；The molecular weight of low molecule sodium hyaluronate for 10kDa-1000kDa it
Between, 10 kDa of molecular weight ＜ of oligomerization sodium hyaluronate.
8. it is as claimed in claim 5 it is a kind of can the preparation method of sodium hyaluronate stoste that imports of micropin, it is characterised in that：The breast
Change pot using the complete emulsifying devices of Fu Luke, unit type FISCO-10L.
9. it is as claimed in claim 5 it is a kind of can the preparation method of sodium hyaluronate stoste that imports of micropin, it is characterised in that：Step 4）
Described in moist heat sterilization temperature be 110 DEG C -130 DEG C, sterilization time 6min-10min.
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| CN111265590A (en) * | 2020-01-21 | 2020-06-12 | 华熙生物科技股份有限公司 | Hyaluronic acid freeze-drying preparation for nasal spray and preparation method and application thereof |
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| CN113116745A (en) * | 2019-12-31 | 2021-07-16 | 华熙生物科技股份有限公司 | Hyaluronic acid noninvasive soluble microneedle patch and preparation method thereof |
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| CN111297727A (en) * | 2019-12-25 | 2020-06-19 | 华熙生物科技股份有限公司 | Beautifying and plasticizing treatment composition and application thereof |
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| CN113116745B (en) * | 2019-12-31 | 2022-11-04 | 华熙生物科技股份有限公司 | Hyaluronic acid noninvasive soluble microneedle patch and preparation method thereof |
| CN111265590A (en) * | 2020-01-21 | 2020-06-12 | 华熙生物科技股份有限公司 | Hyaluronic acid freeze-drying preparation for nasal spray and preparation method and application thereof |
| CN113679619A (en) * | 2021-09-03 | 2021-11-23 | 无限极（中国）有限公司 | Acne removing microneedle and preparation method thereof |
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