CN107468538A - A kind of medical reparation patch and preparation method thereof - Google Patents
A kind of medical reparation patch and preparation method thereof Download PDFInfo
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- CN107468538A CN107468538A CN201611128027.4A CN201611128027A CN107468538A CN 107468538 A CN107468538 A CN 107468538A CN 201611128027 A CN201611128027 A CN 201611128027A CN 107468538 A CN107468538 A CN 107468538A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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Abstract
A kind of medical reparation patch and preparation method thereof, belongs to two class technical field of medical instruments, and the product for solving the problems, such as existing treatment acne is present, a kind of medical reparation patch, and it includes facial mask cloth and the decoction being infiltrated on facial mask cloth；The decoction component is by volume comprising the Sodium Hyaluronate 0.05% 0.35% that molecular weight is 0.1 ten thousand 0.9 ten thousand Da, the Da of molecular weight 800,000 160 ten thousand Sodium Hyaluronate 0.08% 0.40%, the Da of molecular weight 1,800,000 250 ten thousand Sodium Hyaluronate 0.05% 0.20%, preservative 0.01% 0.10%, thickener 0.05% 0.30%, surplus is water for injection；Or the Da of molecular weight 0.1 ten thousand 0.9 ten thousand Sodium Hyaluronate 0.05% 0.35%, the Da of molecular weight 800,000 160 ten thousand Sodium Hyaluronate 0.08% 0.50%, preservative 0.01% 0.10%, thickener 0.05% 0.40%, surplus is water for injection；The present invention is used to treat acne.
Description
Technical field
The invention belongs to two class technical field of medical instruments, and in particular to a kind of medical reparation patch and preparation method thereof.
Background technology
Acne, acne are commonly called as, are a kind of common hair follicle, sebaceous glands chronic inflammatory diseases, are mainly in puberty, and face
More obvious, clinical manifestation damages including inflammatory type（Papule, warts, tubercle and tumour）Damaged with noninflammatory type（Including blackhead
Acne and Whiteheads）；The scar that acne can frequently result in face more afterwards is formed, and treatment is difficult, can exist throughout one's life, early stage and
When and regular treatment acne can substantially shorten the course of disease and the formation of scar can be prevented；The product composition ratio of existing treatment acne
It is more complicated, the materials such as heavy metal, hormone, antibiotic are usually contained, its side effect is obvious, medication dependence be present, as notification number is
CN104434666A, patent name are《A kind of skin repairs facial mask and preparation method thereof》In disclosed technology, it, which is added, increases
Solvent PE-40 rilanit specials, nertralizer triethanolamine, essence, these additives produce burden to damaged skin, are unfavorable for flesh
Skin reparation, " chromium " and " neodymium " contained in spices belong to disabling element, if the weaker patient of skin resistance uses, skin will
There is excitement and burning sensation, or it is skin sensitivity, rubescent, and serious may result in dermatitis, and chromium is that skin allergic reaction is former, can
Cause allergic dermatitis or eczema, course of disease length, long without more, neodymium has very strong excitant to eyes and mucous membrane, in having to skin
Excitant is spent, suction can also result in pulmonary embolism and hepatic lesion.
The content of the invention
The invention aims to solve above mentioned problem existing for the product of existing treatment acne, there is provided a kind of medical
Patch and preparation method thereof is repaired, its technical scheme is as follows：
A kind of medical reparation patch, it includes facial mask cloth and the decoction being infiltrated on facial mask cloth；
The facial mask cloth uses non-woven cloth, as non-woven fabrics, silk fabric, string film add PP backing materials, binchotan film, work
Property carbon membrane, pulp fiber cloth, native cellulose fibre non-woven fabrics etc.；
The decoction component is by volume comprising the Sodium Hyaluronate 0.05%-0.35% that molecular weight is 0.1 ten thousand -0.9 ten thousand Da, molecule
Measure 800,000-160 ten thousand Da Sodium Hyaluronate 0.08%-0.40%, the Da of molecular weight 1,800,000-250 ten thousand Sodium Hyaluronate 0.05%-
0.20%, preservative 0.01%-0.10%, thickener 0.05%-0.30%, surplus are water for injection；Or molecular weight 0.1 ten thousand -0.9 ten thousand
Da Sodium Hyaluronate 0.05%-0.35%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.08%-0.50%, preservative
0.01%-0.10%, thickener 0.05%-0.40%, surplus are water for injection.
Preservative is using Sodium Methyl Hydroxybenzoate, nipagin A sodium, Sodium Propyl Hydroxybenzoate, right
One or more in butoben sodium, pentanediol；
Thickener using xanthans, AVC thickeners, carbomer, macromolecule polywater thing, one kind in nutrition wire-drawing protein matter sodium or
More than one.
A kind of above-mentioned medical preparation method for repairing patch, it is comprised the steps of：
The first step, 80% water for injection being equally divided into two parts, thickener and preservative dissolve in a water for injection respectively,
Colloidal solution and antiseptic solution is made；
Second step, after colloidal solution made from the first step and antiseptic solution are well mixed, all transparent matter acid sodium is added, is mixed
It is even, adjust pH value to add remaining water constant volume to 6.0-7.5, decoction is made with sodium hydroxide or hydrochloric acid；
3rd step, by facial mask bag of the medicine liquid irrigation made from second step loaded on prepackage facial mask cloth, seal, mounted box.
Beneficial effects of the present invention are：The Da of molecular weight 0.1 ten thousand -0.9 ten thousand hyaluronic acid may penetrate into the epidermis of skin,
The moisture in skin is kept, promotes the supply of nutriment and the excretion of unwanted metabolite thing；The Da's of molecular weight 800,000-160 ten thousand is saturating
Bright matter acid sodium can promote injury skin regeneration by promoting epidermal cell proliferation and differentiation and scavenging activated oxygen,
Combined in dermal matrix with protein, space between cells is present in the form of protein complex, formed gel, cell adhesion is existed
Together, cell metabolism of bringing into normal play and the effect for organizing water holding, make Skin Cell from invading pathogens, prevent from infecting；Molecule
It is high molecular polymer to measure 1,800,000-250 ten thousand Da hyaluronic acids, there is very strong lubricity and film forming, can be formed in skin surface
Thin film, it is allowed to produce good smooth and moist feeling, hinders epidermal cell water loss, plays a part of protecting skin；
The Da of molecular weight 0.1 ten thousand-0.9 ten thousand and the Da of molecular weight 800,000-160 ten thousand two kinds of Sodium Hyaluronate admixing medical solutions may penetrate into skin table
Layer, promote injury regeneration, make cell from invading pathogens；The Da of molecular weight 0.1 ten thousand-0.9 ten thousand, molecular weight 800,000-160 ten thousand
Da and the Da of molecular weight 1,800,000-250 ten thousand three kinds of Sodium Hyaluronate admixing medical solutions film forming can be protected on the basis of reparative regeneration
Shield, increase wetability protection skin.
The present invention is different from traditional wet type dressing, can provide the environment of moistening, and and can is effectively protected and repaired
Skin.Improve epidermal cell microenvironment, fill up skin tissue cell epimatrix and promote skin histology metabolism, suitable for each
Kind of skin is acute, chronic injury healing.To acne more after, the allergic treatment early postoperation pigmentation with laser photon and
Mitigating scar also has auxiliary therapeutic action.This product not spirituosity, hormone and antibiotic composition, no dependence, do not rebound, can promote
Enter wound healing and skin repair；It is safe, cause without easy damaged skin or easily allergic material, such as pigment, perfume (or spice)
Larger surfactant of material, excitant etc.；It is applied widely, it is nonirritant, suitable for the crowd of any skin quality；Preparation technology
Succinctly, with short production cycle, production efficiency is high.
Embodiment
A kind of medical reparation patch, it includes facial mask cloth and the decoction being infiltrated on facial mask cloth；
The facial mask cloth uses non-woven cloth, as non-woven fabrics, silk fabric, string film add PP backing materials, binchotan film, work
Property carbon membrane, pulp fiber cloth, native cellulose fibre non-woven fabrics etc.；
The decoction component is by volume comprising the Sodium Hyaluronate 0.05%-0.35% that molecular weight is 0.1 ten thousand -0.9 ten thousand Da, molecule
Measure 800,000-160 ten thousand Da Sodium Hyaluronate 0.08%-0.40%, the Da of molecular weight 1,800,000-250 ten thousand Sodium Hyaluronate 0.05%-
0.20%, preservative 0.01%-0.10%, thickener 0.05%-0.30%, surplus are water for injection；Or molecular weight 0.1 ten thousand -0.9 ten thousand
Da Sodium Hyaluronate 0.05%-0.35%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.08%-0.50%, preservative
0.01%-0.10%, thickener 0.05%-0.40%, surplus are water for injection.
Preservative is using Sodium Methyl Hydroxybenzoate, nipagin A sodium, Sodium Propyl Hydroxybenzoate, right
One or more in butoben sodium, pentanediol；
Thickener using xanthans, AVC thickeners, carbomer, macromolecule polywater thing, one kind in nutrition wire-drawing protein matter sodium or
More than one.
A kind of above-mentioned medical preparation method for repairing patch, it is comprised the steps of：
The first step, 80% water for injection being equally divided into two parts, thickener and preservative dissolve in a water for injection respectively,
Colloidal solution and antiseptic solution is made；
Second step, after colloidal solution made from the first step and antiseptic solution are well mixed, all transparent matter acid sodium is added, is mixed
It is even, adjust pH value to add remaining water constant volume to 6.0-7.5, decoction is made with sodium hydroxide or hydrochloric acid；
3rd step, by facial mask bag of the medicine liquid irrigation made from second step loaded on prepackage facial mask cloth, seal, mounted box.
For the object, technical solutions and advantages of the present invention are more clearly understood, with reference to specific embodiment to this hair
Bright to elaborate, cited embodiment is merely to illustrate technical scheme, rather than design and protection to the present invention
Scope is defined, and does not depart from the modification and replacement of the objective and scope of technical scheme, all should cover the protection model in the present invention
In enclosing.
Embodiment one, the decoction component include the Sodium Hyaluronate 0.05% that molecular weight is 0.1 ten thousand -0.9 ten thousand Da, molecule
Measure 800,000-160 ten thousand Da Sodium Hyaluronate 0.08%, the Da of molecular weight 1,800,000-250 ten thousand Sodium Hyaluronate 0.05%, preservative
0.05%, thickener 0.17%, surplus is water for injection.Volunteer is comfortable on, and symptom improves unobvious.
Embodiment two, the decoction component include the Sodium Hyaluronate 0.35% that molecular weight is 0.1 ten thousand -0.9 ten thousand Da, molecule
Measure 800,000-160 ten thousand Da Sodium Hyaluronate 0.40%, the Da of molecular weight 1,800,000-250 ten thousand Sodium Hyaluronate 0.20%, preservative
0.05%, thickener 0.17%, surplus is water for injection.Volunteer feels uncomfortable, and symptom is obviously improved.
Embodiment three, the decoction component include the Sodium Hyaluronate 0.35% that molecular weight is 0.1 ten thousand -0.9 ten thousand Da, molecule
Measure 800,000-160 ten thousand Da Sodium Hyaluronate 0.08%, the Da of molecular weight 1,800,000-250 ten thousand Sodium Hyaluronate 0.05%, preservative
0.05%, thickener 0.17%, surplus is water for injection.Volunteer is comfortable on, and symptom is eased.
Example IV, the decoction component include the Sodium Hyaluronate 0.25% that molecular weight is 0.1 ten thousand -0.9 ten thousand Da, molecule
Measure 800,000-160 ten thousand Da Sodium Hyaluronate 0.28%, the Da of molecular weight 1,800,000-250 ten thousand Sodium Hyaluronate 0.15%, preservative
0.05%, thickener 0.17%, surplus is water for injection.Volunteer is comfortable on, and symptom is obviously improved.
Implementation column five, the decoction component include the Sodium Hyaluronate 0.25% that molecular weight is 0.5 ten thousand Da, molecular weight 1,500,000
Da Sodium Hyaluronate 0.28%, the Da of molecular weight 2,400,000 Sodium Hyaluronate 0.15%, preservative 0.05%, thickener 0.17% are remaining
Measure as water for injection.
Embodiment six, the decoction component include the Sodium Hyaluronate 0.05% that molecular weight is 0.1 ten thousand -0.9 ten thousand Da, molecular weight 80
Ten thousand -160 ten thousand Da Sodium Hyaluronate 0.08%, preservative 0.05%, thickener 0.20%, surplus are water for injection.Volunteer feels
Comfortably, symptom improves unobvious.
Embodiment seven, the decoction component include the Da of molecular weight 0.1 ten thousand -0.9 ten thousand Sodium Hyaluronate 0.35%, molecular weight
800000-160 ten thousand Da Sodium Hyaluronate 0.50%, preservative 0.05%, thickener 0.20%, surplus are water for injection.Volunteer feels
Feel uncomfortable, symptom is obviously improved.
Embodiment eight, the decoction component include the Da of molecular weight 0.1 ten thousand -0.9 ten thousand Sodium Hyaluronate 0.35%, molecular weight
800000-160 ten thousand Da Sodium Hyaluronate 0.08%, preservative 0.05%, thickener 0.20%, surplus are water for injection.Volunteer feels
Feel comfortable, symptom is eased.
Embodiment nine, the decoction component include the Da of molecular weight 0.1 ten thousand -0.9 ten thousand Sodium Hyaluronate 0.25%, molecular weight
800000-160 ten thousand Da Sodium Hyaluronate 0.25%, preservative 0.05%, thickener 0.20%, surplus are water for injection.Volunteer feels
Feel comfortable, symptom is obviously improved.
Embodiment ten, the decoction component include the Da of molecular weight 0.5 ten thousand Sodium Hyaluronate 0.25%, the Da of molecular weight 1,500,000
Sodium Hyaluronate 0.25%, preservative 0.05%, thickener 0.20%, surplus is water for injection.
Application method：Illing skin is cleaned, this product expansion is spread on illing skin, light pressure makes facial mask cloth be adjacent to skin；
Treatment for early stage pigmentation and scar after light moderate acne and acne healing：Mild acne patient 1 time a day, often
Secondary 1 patch, is often pasted 30 minutes, is used continuously one week, then weekly 2~3 times, be every two weeks a course for the treatment of；Moderate acne patient is every
It 1 time, 1 patch, is often pasted 30 minutes every time, is used continuously one month, then weekly 2~3 times, each moon is a course for the treatment of；
For mitigating rear, allergic acne, the rear early stage pigmentation of laser photon treatment post-operation inflammatory and scar：Daily
1 time, 1 patch, is often pasted 30 minutes every time, is used continuously one week, then weekly 2~3 times, be every two weeks a course for the treatment of.
400 light moderate face acnes volunteer of the above-described embodiment through selecting at random, each people of embodiment user 50,
The effect of result of the test, is divided into Three Estate, symptom is obviously improved, symptom is eased improves unobvious with symptom, will test
As a result comfort level is divided into two grades, comfortable and uncomfortable, result of the test and conclusion is embodiment five and embodiment ten is excellent
Select scheme.
Embodiment 11, decoction component do not include preservative, not affected the treatment, simply shortened shelf life, should cover at this
In the protection domain of invention；In the preparation method first step, 80% water for injection and thickener are mixed to prepare colloidal solution i.e.
Can.
Claims (13)
1. a kind of medical reparation patch, it includes facial mask cloth and the decoction being infiltrated on facial mask cloth；It is characterized in that the decoction
Component is by volume comprising the Sodium Hyaluronate 0.05%-0.35% that molecular weight is 0.1 ten thousand-0.9 ten thousand Da, molecular weight 800,000-160 ten thousand
Da Sodium Hyaluronate 0.08%-0.40%, the Da of molecular weight 1,800,000-250 ten thousand Sodium Hyaluronate 0.05%-0.20%, preservative
0.01%-0.10%, thickener 0.05%-0.30%, surplus are water for injection；Or the Da of molecular weight 0.1 ten thousand -0.9 ten thousand hyaluronic acid
Sodium 0.05%-0.35%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.08%-0.50%, preservative 0.01%-0.10%, increase
Thick dose of 0.05%-0.40%, surplus are water for injection；
Preservative using Sodium Methyl Hydroxybenzoate, nipagin A sodium, Sodium Propyl Hydroxybenzoate, to hydroxyl
One or more in butyl benzoate sodium, pentanediol；
Thickener using xanthans, AVC thickeners, carbomer, macromolecule polywater thing, one kind in nutrition wire-drawing protein matter sodium or
More than one.
2. a kind of medical preparation method for repairing patch as claimed in claim 1, it is characterised in that it is comprised the steps of：
The first step, 80% water for injection being equally divided into two parts, thickener and preservative dissolve in a water for injection respectively,
Colloidal solution and antiseptic solution is made；
Second step, after colloidal solution made from the first step and antiseptic solution are well mixed, all transparent matter acid sodium is added, is mixed
It is even, adjust pH value to add remaining water constant volume to 6.0-7.5, decoction is made with sodium hydroxide or hydrochloric acid；
3rd step, by facial mask bag of the medicine liquid irrigation made from second step loaded on prepackage facial mask cloth, seal.
3. a kind of medical reparation patch as claimed in claim 1, it is characterised in that it is 0.1 that the decoction component, which includes molecular weight,
Ten thousand-0.9 ten thousand Da Sodium Hyaluronate 0.05%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.08%, molecular weight 1,800,000-
2500000 Da Sodium Hyaluronate 0.05%, preservative 0.05%, thickener 0.17%, surplus are water for injection.
4. a kind of medical reparation patch as claimed in claim 1, it is characterised in that it is 0.1 that the decoction component, which includes molecular weight,
Ten thousand-0.9 ten thousand Da Sodium Hyaluronate 0.35%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.40%, molecular weight 1,800,000-
2500000 Da Sodium Hyaluronate 0.20%, preservative 0.05%, thickener 0.17%, surplus are water for injection.
5. a kind of medical reparation patch as claimed in claim 1, it is characterised in that it is 0.1 that the decoction component, which includes molecular weight,
Ten thousand-0.9 ten thousand Da Sodium Hyaluronate 0.35%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.08%, molecular weight 1,800,000-
2500000 Da Sodium Hyaluronate 0.05%, preservative 0.05%, thickener 0.17%, surplus are water for injection.
6. a kind of medical reparation patch as claimed in claim 1, it is characterised in that it is 0.1 that the decoction component, which includes molecular weight,
Ten thousand-0.9 ten thousand Da Sodium Hyaluronate 0.25%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.28%, molecular weight 1,800,000-
2500000 Da Sodium Hyaluronate 0.15%, preservative 0.05%, thickener 0.17%, surplus are water for injection.
7. a kind of medical reparation patch as claimed in claim 1, it is characterised in that it is 0.1 that the decoction component, which includes molecular weight,
Ten thousand-0.9 ten thousand Da Sodium Hyaluronate 0.05%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.08%, preservative 0.05%,
Thickener 0.20%, surplus are water for injection.
A kind of 8. medical reparation patch as claimed in claim 1, it is characterised in that the decoction component include molecular weight 0.1 ten thousand-
0.9 ten thousand Da Sodium Hyaluronate 0.35%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.50%, preservative 0.05%, thickening
Agent 0.20%, surplus are water for injection.
A kind of 9. medical reparation patch as claimed in claim 1, it is characterised in that the decoction component include molecular weight 0.1 ten thousand-
0.9 ten thousand Da Sodium Hyaluronate 0.35%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.08%, preservative 0.05%, thickening
Agent 0.20%, surplus are water for injection.
A kind of 10. medical reparation patch as claimed in claim 1, it is characterised in that the decoction component include molecular weight 0.1 ten thousand-
0.9 ten thousand Da Sodium Hyaluronate 0.25%, the Da of molecular weight 800,000-160 ten thousand Sodium Hyaluronate 0.25%, preservative 0.05%, thickening
Agent 0.20%, surplus are water for injection.
11. a kind of medical reparation patch as claimed in claim 1, it is characterised in that it is 0.5 that the decoction component, which includes molecular weight,
Ten thousand Da Sodium Hyaluronate 0.25%, the Da of molecular weight 1,500,000 Sodium Hyaluronate 0.28%, the Da of molecular weight 2,400,000 hyaluronic acid
Sodium 0.15%, preservative 0.05%, thickener 0.17%, surplus are water for injection.
12. a kind of medical reparation patch as claimed in claim 1, it is characterised in that the decoction component includes molecular weight 0.5 ten thousand
Da Sodium Hyaluronate 0.25%, the Da of molecular weight 1,500,000 Sodium Hyaluronate 0.25%, preservative 0.05%, thickener 0.20% are remaining
Measure as water for injection.
A kind of 13. medical reparation patch as claimed in claim 1, it is characterised in that the facial mask cloth using non-woven fabrics, silk fabric,
String film adds PP backing materials, binchotan film, activated charcoal membrane, pulp fiber cloth or native cellulose fibre non-woven fabrics.
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| CN201611128027.4A CN107468538A (en) | 2016-12-09 | 2016-12-09 | A kind of medical reparation patch and preparation method thereof |
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| CN201611128027.4A CN107468538A (en) | 2016-12-09 | 2016-12-09 | A kind of medical reparation patch and preparation method thereof |
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Cited By (3)
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| CN108815004A (en) * | 2018-08-13 | 2018-11-16 | 哈尔滨医科大学 | A kind of facial mask and preparation method thereof improving corticosteroid dermatitis |
| CN108836979A (en) * | 2018-05-31 | 2018-11-20 | 哈尔滨运美达生物科技有限公司 | A kind of preparation method of sodium hyaluronate reparation patch and reparation patch and reparation patch Essence |
| CN109303876A (en) * | 2018-12-17 | 2019-02-05 | 曲沃李时珍医药科技有限公司 | A kind of medical facial cold compress gel and preparation method thereof for treating acne |
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Cited By (3)
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| CN108815004A (en) * | 2018-08-13 | 2018-11-16 | 哈尔滨医科大学 | A kind of facial mask and preparation method thereof improving corticosteroid dermatitis |
| CN109303876A (en) * | 2018-12-17 | 2019-02-05 | 曲沃李时珍医药科技有限公司 | A kind of medical facial cold compress gel and preparation method thereof for treating acne |
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Application publication date: 20171215 |