CN108158876B - Skin moisturizing and repairing composition and preparation method thereof - Google Patents
Skin moisturizing and repairing composition and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a skin moisturizing and repairing composition and a preparation method thereof. The composition comprises the following components: water, butylene glycol, glycerin, 1, 2-pentanediol, sodium PCA, purslane extract, lotus leaf extract, tea leaf extract, guava leaf extract, angelica koreanum extract, phenoxyethanol, acrylic acid/MA copolymer sodium, hydroxyethyl cellulose, caprylyl glycol, 1, 6-hexanediol, nicotinamide, hydroxyphenylpropionamide benzoic acid, ceramide 3, dipotassium glycyrrhizinate, and sodium hyaluronate. Meanwhile, a preparation method of the skin moisturizing and repairing composition is provided. The composition has good product stability, can permeate into the deep layer of the skin, has good moisturizing effect on the skin, can remove excessive free radicals, promotes the recovery of the skin barrier, and can be used for daily care of various skins, particularly the protection and care of sensitive skins.
Description
Technical Field
The invention relates to a compound preparation, in particular to a skin moisturizing and repairing composition and a preparation method thereof, belonging to the fields of medicines, fine chemicals and personal care product industries.
Technical Field
The skin is the largest organ of the human body, the total weight of the skin accounts for 5% -15% of the body weight, and the skin has barrier effects on two aspects: on one hand, the water, electrolyte and other substances in the body are prevented from losing; on the other hand, the invasion of the outside harmful substances is prevented. And moisture content is an important indicator of skin health. The moisture content of the skin of the old is only 75% of that of the young, so that the moisture content of the skin is preserved, the living environment of skin cells can be improved, the metabolism is promoted, the circulation is increased, and the aims of delaying senility and moistening the skin are fulfilled.
In recent years, the number of people with sensitive skin has increased year by year with increasing dietary structure, atmospheric pollution, life and work pressure. In China, skin sensitivity has also become a social problem affecting the life health of people, and according to the number of pathogenic symptoms, the main manifestations are as follows: facial telangiectasia facial flushing associated with vascular response, skin reactions to specific environments or substances such as light sensitivity and contact dermatitis. The most effective solution to skin sensitivity is to use drugs, but some drugs contain hormones, which may cause hormone-dependent dermatitis after long-term use. Therefore, the development of moisturizing and repairing products for sensitive skin for daily skin care is the problem to be searched and solved at present.
Hyaluronic acid is a linear polysaccharide formed by connecting D-glucuronic acid and N-acetylglucosamine alternately by glycosidic chains, and is widely present in various tissues of the living body. The sodium hyaluronate molecule is a double-spiral structure and can lock and combine with water molecules, and the water retention capacity can reach 100ml/g theoretically, so the sodium hyaluronate molecule is called as a Natural Moisturizing Factor (NMF). The macromolecular sodium hyaluronate can form a breathable film on the surface of the skin, helps the skin to lock water, prevents invasion of external bacteria, dust and ultraviolet rays, and protects the skin from being damaged. The micromolecular sodium hyaluronate has the effects of lasting moisture retention, wrinkle resistance, beauty treatment and skin aging prevention. The oligomeric sodium hyaluronate can rapidly permeate into dermis, slightly dilate capillary vessels, promote blood circulation, improve metabolism and promote nutrient absorption of skin cells. The sodium hyaluronate can enhance the elasticity of skin, delay skin aging, promote the proliferation and differentiation of epidermal cells and the elimination of oxygen free radicals, and plays a certain role in the prevention and repair of skin injury.
Research shows that the functional barrier of the skin of sensitive skin is damaged, the physical barrier function of the horny layer is weakened, the self defense capability of the skin is insufficient, and a series of adverse reactions occur. The loss of ceramide, especially ceramide 3, from the "mortar" component of the skin brick barrier makes the skin more fragile. The traditional ceramide 3 has poor solubility in water, and crystallization can occur if the ceramide is directly added into water. Therefore, certain requirements are imposed on the product process.
Disclosure of Invention
The invention aims to solve the problems and provide a skin moisturizing and repairing compound.
Another object of the present invention is to provide a method for preparing the above skin moisturizing and repairing composition.
The purpose of the invention is realized as follows:
the invention relates to a skin moisturizing and repairing compound which comprises the following components in percentage by mass: 56.5-88.5 parts of water, 2-4 parts of butanediol, 2-8 parts of glycerol, 2-5 parts of 1, 2-pentanediol, 1-3 parts of sodium PCA, 1-10 parts of purslane extract, 0.25-0.5 part of lotus leaf extract, 0.25-0.5 part of tea extract, 0.25-0.5 part of guava leaf extract, 0.25-0.5 part of Korean angelica extract, 0.5-2 parts of nicotinamide, 0.2-0.45 part of hydroxyethyl cellulose, 0.25-0.5 part of acrylic acid/MA copolymer sodium, 0.25-0.5 part of caprylyl glycol, 0.25-0.5 part of 1, 6-hexanediol, 0.1-2 parts of hydroxyphenylpropionamide benzoic acid, 30.1-2 parts of ceramide, 0.1-1 part of dipotassium glycyrrhizinate, 1-1 part of sodium glycyrrhizate, and the like, 0.05 to 0.2 portion of macromolecular sodium hyaluronate, 0.05 to 0.2 portion of low molecular sodium hyaluronate, 0.05 to 0.2 portion of oligomeric sodium hyaluronate and 0.1 to 0.8 portion of phenoxyethanol.
The components are all commercial products.
The invention also provides a process for preparing a skin moisturizing and repairing composition according to claim 1, comprising the steps of:
A. weighing the following components in percentage by mass:
B. uniformly dispersing hydroxyethyl cellulose in a mixture of glycerol and butanediol, adding pentanediol, uniformly stirring, adding 80% of water in the system, and heating to 80-90 ℃. Adding PCA sodium, acrylic acid/MA copolymer sodium, caprylyl glycol and 1, 6-hexanediol, dissolving completely to obtain phase A material, and keeping the temperature at 80-90 deg.C for use;
C. adding herba Portulacae extract, folium Nelumbinis extract, folium Camelliae sinensis extract, folium Psidii Guajavae extract, radix Angelicae sinensis extract, hydroxyphenylpropionamide benzoic acid, ceramide 3, and dipotassium glycyrrhizinate into 10% water, and stirring to obtain phase B material;
D. keeping the temperature of the phase A material at 80-90 deg.C for 90min, cooling to 60 deg.C, adding the phase B material, and stirring for 10 min;
E. sterilizing the rest 10% of water with a high-temperature moist heat sterilizer before extracting, cooling to 40 deg.C after sterilizing, adding high molecular sodium hyaluronate, low molecular sodium hyaluronate and oligomeric sodium hyaluronate, and stirring to obtain phase C;
F.A and B phases are stirred uniformly, then the temperature is reduced, after the temperature is reduced to 40 ℃, C phase and phenoxyethanol are added. And discharging after uniformly mixing.
The skin moisturizing and repairing composition of claim 3, wherein said polymeric sodium hyaluronate has a molecular weight of 1.8 x 106--2.0×106Molecular weight of low molecular sodium hyaluronate is 1.0X 105--5.0×105The molecular weight of oligomeric sodium hyaluronate is less than or equal to 1.0 multiplied by 104。
Hyaluronic acid is an inherent component of human skin, hyaluronic acids with different molecular weights have different effects, sodium hyaluronate with different molecular weights is preferably used as an efficient moisturizing component in the formula, and different sodium hyaluronate has obvious difference in molecular weights and is scientifically matched.
Ceramide 3 is generally poorly soluble in water and may crystallize when added directly to water. Therefore, in the invention, the ceramide 3 is mixed with the purslane extract, the lotus leaf extract, the tea leaf extract, the guava leaf extract, the angelica koreanum extract and the like in advance, and the ceramide is treated by utilizing some natural components in the plant extract, so that the problem of product instability caused by the traditional process is solved.
The plant extracts such as the purslane extract, the lotus leaf extract, the tea leaf extract, the guava leaf extract and the angelica koreanum extract have the effects of moisturizing and repairing the skin, have certain antibacterial property, ensure the safety of products and reduce the addition of traditional preservatives, thereby reducing the stimulation to the skin.
The skin moisturizing and rejuvenating composition according to claim 3 wherein in step E, the sterilization parameters are: 121 ℃ and 21 min.
The sterilization treatment of the C-phase water can reduce the introduction of microorganisms in the preparation process to ensure the production process of the product,
meanwhile, the addition of traditional preservatives can be reduced, so that the irritation to the skin is reduced.
The invention has the following outstanding effects: the skin moisturizing and repairing compound can permeate into the deep layer of the skin, has a good moisturizing effect on the skin, can remove excessive free radicals, promotes the recovery of a skin barrier, and can be used for daily care of various skins, particularly the protection and care of sensitive skins.
According to the preparation method, the components are subjected to phase splitting premixing according to properties, and parameters such as temperature, time and the like in the preparation process are controlled, so that the raw materials are fully dissolved, and the product has high stability.
Detailed Description
The present invention will be further described with reference to the following examples.
Examples 1 to 5
In the above raw materials, the water is deionized water or water for injection.
Examples 1-5 were carried out by the following procedure.
Firstly, uniformly dispersing hydroxyethyl cellulose in a mixture of glycerol and butanediol, adding pentanediol, uniformly stirring, adding water accounting for 80% of the system, and heating to 80-90 ℃. Adding PCA sodium, acrylic acid/MA copolymer sodium, caprylyl glycol and 1, 6-hexanediol, dissolving completely to obtain phase A material, and keeping the temperature at 80-90 deg.C for use;
adding purslane extract, lotus leaf extract, tea leaf extract, guava leaf extract, angelica koreanum extract, hydroxyphenylpropionamide benzoic acid, ceramide 3 and dipotassium glycyrrhizinate into 10 percent of water in the system, and uniformly stirring to obtain a B-phase material;
thirdly, preserving the temperature of the phase A material at 80-90 ℃ for 90min, then cooling, adding the phase B material after cooling to 60 ℃, and stirring for 10 min;
fourthly, sterilizing the rest 10 percent of water before extraction by using a high-temperature moist heat sterilizer, cooling to 40 ℃ after sterilization, adding the high-molecular sodium hyaluronate, the low-molecular sodium hyaluronate and the oligomeric sodium hyaluronate, and uniformly stirring to obtain a phase C;
and fifthly, after uniformly stirring the phase A and the phase B, cooling, and adding the phase C and phenoxyethanol after cooling to 40 ℃. And discharging after uniformly mixing.
The high temperature accelerated tests (40 ℃, product indexes of 1 month, 2 months, 3 months, 4 months, 5 months and 6 months respectively) of examples 1 to 5 were carried out, and the detection results are as follows:
| detecting items | Appearance of the product | Ph value | Microbiological indicator | Hyaluronic acid content |
| 1 month | Qualified | Qualified | Qualified | Qualified |
| 2 months old | Qualified | Qualified | Qualified | Qualified |
| 3 months old | Qualified | Qualified | Qualified | Qualified |
| 4 months old | Qualified | Qualified | Qualified | Qualified |
| For 5 months | Qualified | Qualified | Qualified | Qualified |
| 6 months old | Qualified | Qualified | Qualified | Qualified |
The results show that: the skin moisturizing and repairing composition has good stability, the ceramide 3 is not precipitated, the ph value and the microorganism both meet the requirements of products sold in the market, and meanwhile, the content of the hyaluronic acid does not fluctuate, so that the expected shelf life is met.
The stability tests (testing the product indexes at normal temperature for 0 month, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months and 36 months) of the examples 1 to 5 are carried out, and the detection results are as follows:
| detecting items | Appearance of the product | Ph value | Microbiological indicator | Hyaluronic acid content |
| 0 month | Qualified | Qualified | Qualified | Qualified |
| 3 months old | Qualified | Qualified | Qualified | Qualified |
| 6 months old | Qualified | Qualified | Qualified | Qualified |
| 9 months old | Qualified | Qualified | Qualified | Qualified |
| 12 months old | Qualified | Qualified | Qualified | Qualified |
| 18 months old | Qualified | Qualified | Qualified | Qualified |
| 24 months | Qualified | Qualified | Qualified | Qualified |
| 36 months old | Qualified | Qualified | Qualified | Qualified |
The results show that: the skin moisturizing and repairing composition has good stability, the ceramide 3 is not precipitated, the ph value and the microorganism both meet the requirements of products sold in the market, and meanwhile, the content of the hyaluronic acid does not fluctuate and meets the specified shelf life.
Comparing the examples 1-5 with the current commercially available repair products, and evaluating the efficacy, wherein the number of the tested persons is 60, and the test process is as follows: after cleaning face for 30min (no water supplement, no violent exercise) for 60 volunteers, the following indexes-water, water loss, heme, skin surface temperature and melanin were tested by a multifunctional skin tester CK. The test site was marked by a photograph of the original spot on the face.
The volunteers were randomly grouped, 30 volunteers in the experimental group continuously used the present invention for 7 days, and 30 volunteers in the control group continuously used the same products sold in the market for 7 days, 30min after cleaning face, and the following indexes were tested by a multifunctional skin tester CK: water, water loss, hemoglobin, skin surface temperature, melanin. Note that the test positions are consistent with those in [ 0044 ].
The specific test items are as follows:
the detection results are as follows:
the results of the tests of examples 1-5 demonstrate that the skin moisturizing repair compositions of the present invention are generally superior to commercially available products, particularly in terms of moisture replenishment, reduction of skin water loss, and skin hemoglobin.
The foregoing is merely for the purpose of illustrating the invention and is not to be construed as limiting the invention, since various changes and modifications may be made therein by those skilled in the art without departing from the spirit and scope of the invention, it is intended that all matter contained in the above description be interpreted as broadly as possible and all changes and equivalents thereof are deemed to be embraced therein.
Claims (5)
1. The skin moisturizing and repairing composition is characterized by comprising the following components in parts by mass: 56.5-88.5 parts of water, 2-4 parts of butanediol, 2-8 parts of glycerol, 2-5 parts of 1, 2-pentanediol, 1-3 parts of sodium PCA, 1-10 parts of purslane extract, 0.25-0.5 part of lotus leaf extract, 0.25-0.5 part of tea extract, 0.25-0.5 part of guava leaf extract, 0.25-0.5 part of Korean angelica extract, 0.5-2 parts of nicotinamide, 0.2-0.45 part of hydroxyethyl cellulose, 0.25-0.5 part of acrylic acid/MA copolymer sodium, 0.25-0.5 part of caprylyl glycol, 0.25-0.5 part of 1, 6-hexanediol, 0.1-2 parts of hydroxyphenylpropionamide benzoic acid, 30.1-2 parts of ceramide, 0.1-1 part of dipotassium glycyrrhizinate, 1-1 part of sodium glycyrrhizate, and the like, 0.05 to 0.2 portion of macromolecular sodium hyaluronate, 0.05 to 0.2 portion of low molecular sodium hyaluronate, 0.05 to 0.2 portion of oligomeric sodium hyaluronate and 0.1 to 0.8 portion of phenoxyethanol;
the preparation method of the skin moisturizing and repairing composition comprises the following steps:
A. weighing the following raw materials in parts by weight:
B. uniformly dispersing hydroxyethyl cellulose in a mixture of glycerol and butanediol, adding pentanediol, uniformly stirring, adding 80% of water in the system, and heating to 80-90 ℃;
adding PCA sodium, acrylic acid/MA copolymer sodium, caprylyl glycol and 1, 6-hexanediol, dissolving completely to obtain phase A material, and keeping the temperature at 80-90 deg.C for use;
C. adding herba Portulacae extract, folium Nelumbinis extract, folium Camelliae sinensis extract, folium Psidii Guajavae extract, radix Angelicae sinensis extract, hydroxyphenylpropionamide benzoic acid, ceramide 3, nicotinamide, and dipotassium glycyrrhizinate into 10% water in the system, and stirring to obtain phase B material;
D. keeping the temperature of the phase A material at 80-90 deg.C for 90min, cooling to 60 deg.C, adding the phase B material, and stirring for 10 min;
E. sterilizing the rest 10% of water with a high-temperature moist heat sterilizer before extracting, cooling to 40 deg.C after sterilizing, adding high molecular sodium hyaluronate, low molecular sodium hyaluronate and oligomeric sodium hyaluronate, and stirring to obtain phase C;
F.A and B phases are stirred uniformly, then the temperature is reduced, after the temperature is reduced to 40 ℃, C phase and phenoxyethanol are added, and the materials are discharged after being mixed uniformly.
2. The skin moisturizing and repairing composition as claimed in claim 1, wherein the molecular weight of the polymeric sodium hyaluronate is 1.8 x 106--2.0×106Molecular weight of low molecular sodium hyaluronate is 1.0X 105--5.0×105The molecular weight of oligomeric sodium hyaluronate is less than or equal to 1.0 multiplied by 105。
3. A method of preparing the skin moisturizing and rejuvenating composition of claim 1 comprising the steps of:
A. the raw materials are weighed according to the components and the parts by weight of the components in the claim 1:
B. uniformly dispersing hydroxyethyl cellulose in a mixture of glycerol and butanediol, adding pentanediol, uniformly stirring, adding 80% of water in the system, and heating to 80-90 ℃;
adding PCA sodium, acrylic acid/MA copolymer sodium, caprylyl glycol and 1, 6-hexanediol, dissolving completely to obtain phase A material, and keeping the temperature at 80-90 deg.C for use;
C. adding herba Portulacae extract, folium Nelumbinis extract, folium Camelliae sinensis extract, folium Psidii Guajavae extract, radix Angelicae sinensis extract, hydroxyphenylpropionamide benzoic acid, ceramide 3, nicotinamide, and dipotassium glycyrrhizinate into 10% water in the system, and stirring to obtain phase B material;
D. keeping the temperature of the phase A material at 80-90 deg.C for 90min, cooling to 60 deg.C, adding the phase B material, and stirring for 10 min;
E. sterilizing the rest 10% of water with a high-temperature moist heat sterilizer before extracting, cooling to 40 deg.C after sterilizing, adding high molecular sodium hyaluronate, low molecular sodium hyaluronate and oligomeric sodium hyaluronate, and stirring to obtain phase C;
F.A and B phases are stirred uniformly, then the temperature is reduced, after the temperature is reduced to 40 ℃, C phase and phenoxyethanol are added, and the materials are discharged after being mixed uniformly.
4. The method of claim 3 wherein the polymeric sodium hyaluronate has a molecular weight of 1.8 x 106--2.0×106Molecular weight of low molecular sodium hyaluronate is 1.0X 105--5.0×105The molecular weight of oligomeric sodium hyaluronate is less than or equal to 1.0 multiplied by 104。
5. A method of preparing a skin moisturizing and rejuvenating composition according to claim 3 wherein in step E, the sterilization parameters are: 121 ℃ and 21 min.
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| CN109674679A (en) * | 2019-01-28 | 2019-04-26 | 贝德氏（上海）健康科技股份有限公司 | A kind of skin barrier maintenance biomembrane and preparation method thereof |
| CN110004764A (en) * | 2019-04-09 | 2019-07-12 | 华熙生物科技股份有限公司 | A kind of paper product additive of the substance containing hyaluronic acid |
| CN110742834A (en) * | 2019-11-29 | 2020-02-04 | 西安博和医疗科技有限公司 | Skin repair composition and preparation method thereof |
| CN111956562B (en) * | 2020-09-25 | 2023-03-21 | 山东华熙海御生物医药有限公司 | Moisturizing liquid and mask moisturizing cotton batten |
| CN112842985A (en) * | 2021-02-08 | 2021-05-28 | 广州花出见生物科技有限公司 | Moisturizing and repairing composition |
| CN112972293B (en) * | 2021-02-23 | 2023-03-21 | 云南贝泰妮生物科技集团股份有限公司 | Composition with high ceramide content, preparation and low-energy-consumption preparation method thereof |
| CN114601761A (en) * | 2022-01-18 | 2022-06-10 | 科丝美诗(中国)化妆品有限公司 | Preparation method and application of plant fermentation liquor for repairing skin barrier |
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| CN104435366A (en) * | 2014-10-30 | 2015-03-25 | 徐澄飞 | Composition containing herbal extract and makeup material composition |
| CN104622765A (en) * | 2015-03-06 | 2015-05-20 | 广东雅丽洁精细化工有限公司 | Beauty mask containing compound type collagen and high-low molecular hyaluronic acid |
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