CN109674679A - A kind of skin barrier maintenance biomembrane and preparation method thereof - Google Patents
A kind of skin barrier maintenance biomembrane and preparation method thereof Download PDFInfo
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- CN109674679A CN109674679A CN201910081425.2A CN201910081425A CN109674679A CN 109674679 A CN109674679 A CN 109674679A CN 201910081425 A CN201910081425 A CN 201910081425A CN 109674679 A CN109674679 A CN 109674679A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention belongs to chemical product and skin care fields more particularly to a kind of skin barrier maintenance biomembrane and preparation method thereof.Skin barrier maintenance biomembrane of the present invention is to be prepared by raw materials such as soybean protein isolate, triethanolamine, Sodium Hyaluronate, ceramide, plant extraction liquid, glycyrrhizic acid, moisturizer, hydroxyethyl cellulose, vitamin E, xanthan gum, essence, preservative, pigment, boric acid and deionized waters through modern crafts means.After tested, skin barrier maintenance biomembrane of the present invention has the effect of ideal strong protecting skin and maintenance skin barrier function, furthermore, biomembrane prescription of the present invention is simple, easy to control the quality, Sodium Hyaluronate additive amount is lower in its composition of raw materials, effectively controls production cost, at the same time, due to joined the plant extracts obtained through special process processing in biological film formulation of the invention, every skin care performance of product is improved significantly.Therefore, biomembrane of the present invention is very suitable to the current market demand.
Description
Technical field
The invention belongs to chemical product and skin care field more particularly to a kind of skin barrier maintenance biomembrane and its preparation sides
Method.
Background technique
Hyaluronic acid, also known as sodium hyaluronate are made of two dissacharide units D-Glucose aldehydic acid and N-acetyl-glucosamine
Large-scale polysaccharide is a kind of ideal natural moisturizing factor, increases skin elasticity because it has, improves skin barrier function, rush
Absorbed into nutritional ingredient, improve skin-nourishing metabolism, make skin it is tender it is smooth, go a variety of skin-protecting face nursings effects of wrinkle anti-aging etc.,
It is widely used in skin care item and chemical product.
Often compounding is used to prepare skin repair biomembrane class product to hyaluronic acid together with emulsifier, moisturizer, not only
Have the function of moisturizing, repair damaged skin barrier, it may also be used for the skin diseases such as adjuvant treatment dermatitis, eczema.However, due to
Hyaluronic acid price is higher, and when additive amount is more, it is excessively high to will lead to production cost, and when additive amount is lower, skin care and repairs
The effect for protecting skin barrier function is unobvious, therefore, how under the premise of guaranteeing reasonable cost to promote its skin care as much as possible
Effect with maintenance skin barrier function is the practical problem of long-standing problem researcher.
Summary of the invention
The present invention is largely screened by the composition of raw materials to hyaluronic acid skin repair biomembrane product, and is given birth to it
Production. art step and parameter optimize, and develop and obtain a kind of new compound skin barrier maintenance biology comprising plant component
Film.In skin barrier maintenance biology film formulation of the present invention, Sodium Hyaluronate additive amount is very low, effectively controls production cost,
At the same time, due to joined plant extracts --- the levant cotton exocarp obtained through special process processing in biological film formulation of the invention
With hemp seed and husk extracting solution, so that product of the present invention is in the case where low Sodium Hyaluronate additive amount, skin care, moisturizing, maintenance
The effect of skin barrier function has still obtained being promoted more significantly.
The present invention provides a kind of skin barrier maintenance biomembranes, it is made of the raw material of following weight parts:
It is formulated specification:
Soybean protein isolate main function is nutrition skin in this formula, repairs impaired cutin；
Triethanolamine also acts as the effect of equilibrium product pH value as emulsifier and thickener；
Sodium Hyaluronate, ceramide and plant extraction liquid synergistic effect, it is intended to enhance skin effect and maintenance skin screen
Hinder function；
Glycyrrhizic acid for reducing product irritation, while can promote skin repair, reduce free radical injury；
Moisturizer is used for moisturizing, water lock moisturizing；
Hydroxyethyl cellulose is used as thickener and skin lubrication agent；
Vitamin E can prevent the oxidisability injury of skin as antioxidant；
Xanthan gum is as thickener and stabilizer；
Boric acid is used for sterilizing, and assists in the treatment of scytitis.
Further, the plant extraction liquid for including in skin barrier maintenance biology film raw material of the present invention is by following weight parts
Raw material made of:
Levant cotton exocarp 65；
Hemp seed and husk 35；
The preparation method is as follows:
120 mesh powders will be ground into after levant cotton exocarp and hemp seed and husk mixing, water rinsing, 45-50 DEG C of drying, to gained powder
8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕, 0.4 mixed solvents are added in end, refluxing extraction 15 minutes after impregnating 30 minutes, filters, abandons
Filtrate is gone, 20 times of 7% ethyl alcohol of amount are added into filter residue, refluxing extraction 1 hour after impregnating 30 minutes, is filtered, filtrate decompression concentration 5
Plant extraction liquid is obtained after times.
Preferably, the moisturizer for including in skin barrier maintenance biology film raw material of the present invention in following compositions at least
It is a kind of: glycerol, ethylene glycol, propylene glycol, sorbierite, more ethylene glycol.
Preferably, the preservative for including in skin barrier maintenance biology film raw material of the present invention in following compositions at least
It is a kind of: p-hydroxybenzoate, parahydroxyacet-ophenone, cetyl dimethyl benzyl ammonium bromide, methylisothiazolinone, imidazoles
Ureine, phenoxetol, iodopropynyl butyl formate, bronopol, Chlorphenesin.
Further, skin barrier maintenance biomembrane of the present invention is prepared through following step:
(1) preparation of plant extraction liquid: levant cotton exocarp and hemp seed and husk are mixed, water rinses, is ground into after 45-50 DEG C of drying
8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕, 0.4 mixed solvents are added into gained powder for 120 mesh powders, return after impregnating 30 minutes
Stream extracts 15 minutes, filters, discards filtrate, and 20 times of 7% ethyl alcohol of amount are added into filter residue, and refluxing extraction 1 is small after impregnating 30 minutes
When, it filters, filtrate decompression obtains plant extraction liquid after being concentrated 5 times；
(2) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts, 30 DEG C of immersion 1- being added into hydroxyethyl cellulose
2h is spare after being swollen it sufficiently；
(3) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, neural acyl
70 DEG C of constant temperature stirrings are heated to after amine, above-mentioned plant extraction liquid, glycyrrhizic acid, moisturizer, vitamin E, xanthan gum, boric acid mixing
15min mixes well it, obtains mixed material；
(4) preparation of finished product: by said mixture material slow cooling to sequentially added after 30 DEG C thereto essence, pigment and
Preservative mixes well it in 30 DEG C of constant temperature stirring 10min, it then is added in the hydroxyethyl cellulose after above-mentioned swelling
In, 30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
As a preference, the parts by weight of each raw material of skin barrier maintenance biomembrane of the present invention, which are made, is:
Wherein the plant extraction liquid is made of the raw material of following weight parts:
Levant cotton exocarp 65；
Hemp seed and husk 35；
The preparation method is as follows:
120 mesh powders will be ground into after levant cotton exocarp and hemp seed and husk mixing, water rinsing, 45-50 DEG C of drying, to gained powder
8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕, 0.4 mixed solvents are added in end, refluxing extraction 15 minutes after impregnating 30 minutes, filters, abandons
Filtrate is gone, 20 times of 7% ethyl alcohol of amount are added into filter residue, refluxing extraction 1 hour after impregnating 30 minutes, is filtered, filtrate decompression concentration 5
Plant extraction liquid is obtained after times；
The moisturizer is selected from least one of following compositions: glycerol, ethylene glycol, propylene glycol, sorbierite, more second two
Alcohol；
The preservative is selected from least one of following compositions: p-hydroxybenzoate, parahydroxyacet-ophenone, hexadecane
Base dimethylbenzyl ammonium bromide, methylisothiazolinone, imidazolidinyl urea, phenoxetol, iodopropynyl formic acid fourth
Ester, bronopol, Chlorphenesin.
Further, the raw material for skin barrier maintenance biomembrane of the present invention being made further includes following weight parts:
Periploca spium leaf extract 3.9-4.5；
The periploca spium leaf extract is prepared through following methods: will be added 10 times after the rinsing of periploca spium leaf water, dry, crushing
The sodium bicarbonate aqueous solution of amount 1.5% decocts 1 hour after impregnating 1 hour, filters, filtrate is spare, and filter residue weighs under the same conditions
It extracts 1 time again, merging filtrate, periploca spium leaf extract is obtained after gained filtrate decompression is concentrated 5 times.
As another preferred embodiment, the parts by weight of each raw material of skin barrier maintenance biomembrane of the present invention, which are made, is:
Further, above-mentioned skin barrier maintenance biomembrane is prepared through following step:
(1) preparation of plant extraction liquid: levant cotton exocarp and hemp seed and husk are mixed, water rinses, is ground into after 45-50 DEG C of drying
8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕, 0.4 mixed solvents are added into gained powder for 120 mesh powders, return after impregnating 30 minutes
Stream extracts 15 minutes, filters, discards filtrate, and 20 times of 7% ethyl alcohol of amount are added into filter residue, and refluxing extraction 1 is small after impregnating 30 minutes
When, it filters, filtrate decompression obtains plant extraction liquid after being concentrated 5 times；
(2) preparation of periploca spium leaf extract: by the rinsing of periploca spium leaf water, dry, 10 times of amounts 1.5% of addition after crushing carbonic acid
Hydrogen sodium water solution decocts 1 hour after impregnating 1 hour, filters, and filtrate is spare, and filter residue repeats to extract 1 time under the same conditions, closes
And filtrate, periploca spium leaf extract is obtained after gained filtrate decompression is concentrated 5 times；
(3) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts, 30 DEG C of immersion 1- being added into hydroxyethyl cellulose
2h is spare after being swollen it sufficiently；
(4) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, neural acyl
Add after amine, above-mentioned plant extraction liquid, above-mentioned periploca spium leaf extract, glycyrrhizic acid, moisturizer, vitamin E, xanthan gum, boric acid mixing
Heat mixes well it to 70 DEG C of constant temperature stirring 15min, obtains mixed material；
(5) preparation of finished product: by said mixture material slow cooling to sequentially added after 30 DEG C thereto essence, pigment and
Preservative mixes well it in 30 DEG C of constant temperature stirring 10min, it then is added in the hydroxyethyl cellulose after above-mentioned swelling
In, 30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
In addition, including the following steps: the present invention also provides a kind of preparation method of skin barrier maintenance biomembrane
(1) composition of raw materials:
(2) preparation of plant extraction liquid: the levant cotton exocarp of 65 parts by weight and the hemp seed and husk of 35 parts by weight are mixed, water floats
It washes, be ground into 120 mesh powders after 45-50 DEG C of drying, it is mixed that 8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕ 0.4 are added into gained powder
Bonding solvent refluxing extraction 15 minutes after impregnating 30 minutes, filters, discards filtrate, and 20 times of 7% ethyl alcohol of amount, leaching are added into filter residue
Bubble filters refluxing extraction 1 hour after 30 minutes, and filtrate decompression obtains plant extraction liquid after being concentrated 5 times；
(3) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts, 30 DEG C of immersion 1- being added into hydroxyethyl cellulose
2h is spare after being swollen it sufficiently；
(4) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, neural acyl
70 DEG C of constant temperature stirrings are heated to after amine, above-mentioned plant extraction liquid, glycyrrhizic acid, glycerol, vitamin E, xanthan gum, boric acid mixing
15min mixes well it, obtains mixed material；
(5) preparation of finished product: by said mixture material slow cooling to sequentially added after 30 DEG C thereto essence, pigment and
Chlorphenesin mixes well it in 30 DEG C of constant temperature stirring 10min, it then is added in the hydroxyethyl cellulose after above-mentioned swelling
In, 30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
After tested, skin barrier maintenance biomembrane of the present invention has ideal strong protecting skin effect.In addition, of the invention
Biomembrane prescription is simple, easy to control the quality, and Sodium Hyaluronate additive amount is lower in composition of raw materials, effectively controls production cost,
At the same time, due to joined the plant extract obtained through special process processing in skin barrier maintenance biology film formulation of the present invention
Object --- levant cotton exocarp and hemp seed and husk extracting solution, so that product of the present invention in the case where low Sodium Hyaluronate additive amount, is protected
Skin, moisturizing, maintenance skin barrier function effect still obtained being promoted more significantly.Therefore, biomembrane of the present invention is very suitable
Close the current market demand.
Specific embodiment
Illustrate embodiments of the present invention below by way of specific specific example, those skilled in the art can be by this specification
Other advantages and efficacy of the present invention can be easily understood for disclosed content.The present invention can also pass through in addition different specific realities
The mode of applying is embodied or practiced, the various details in this specification can also based on different viewpoints and application, without departing from
Various modifications or alterations are carried out under spirit of the invention.
Unless otherwise defined, all technical and scientific terms and those skilled in the art of the present technique used in the present invention are usual
The meaning of understanding is identical.In addition to specific method, equipment, material used in the embodiment, according to those skilled in the art
Grasp and record of the invention to the prior art, can also use and method described in the embodiment of the present invention, equipment, material
Any method, equipment and the material of the similar or equivalent prior art realizes the present invention.
Embodiment 1
A kind of skin barrier maintenance biomembrane, is made of the raw material of following weight parts:
The preparation method is as follows:
(1) preparation of plant extraction liquid: the levant cotton exocarp of 65 parts by weight and the hemp seed and husk of 35 parts by weight are mixed, water floats
It washes, be ground into 120 mesh powders after 45-50 DEG C of drying, it is mixed that 8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕ 0.4 are added into gained powder
Bonding solvent refluxing extraction 15 minutes after impregnating 30 minutes, filters, discards filtrate, and 20 times of 7% ethyl alcohol of amount, leaching are added into filter residue
Bubble filters refluxing extraction 1 hour after 30 minutes, and filtrate decompression obtains plant extraction liquid after being concentrated 5 times；
(2) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts, 30 DEG C of immersion 1- being added into hydroxyethyl cellulose
2h is spare after being swollen it sufficiently；
(3) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, neural acyl
70 DEG C of constant temperature stirrings are heated to after amine, above-mentioned plant extraction liquid, glycyrrhizic acid, glycerol, vitamin E, xanthan gum, boric acid mixing
15min mixes well it, obtains mixed material；
(4) preparation of finished product: by said mixture material slow cooling to sequentially added after 30 DEG C thereto essence, pigment and
Chlorphenesin mixes well it in 30 DEG C of constant temperature stirring 10min, it then is added in the hydroxyethyl cellulose after above-mentioned swelling
In, 30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
Product quality requirement
[organoleptic indicator]
Appearance: this product should be uniform thick liquid, free from admixture.
Color: this product should be white to faint yellow.
Fragrance: this product should have specific fragrance, free from extraneous odour.
[physical and chemical index]
1 physical and chemical index of table
| Inspection project | Index |
| It is heat-resisting | (40 ± 1) DEG C are kept for 24 hours, preceding without obvious Traits change with test after restoring to room temperature |
| It is cold-resistant | (5 ± 1) DEG C are kept for 24 hours, preceding without obvious Traits change with test after restoring to room temperature |
| PH | PH value should be 6.0~6.8 |
Embodiment 2
A kind of skin barrier maintenance biomembrane, is made of the raw material of following weight parts:
The preparation method is as follows:
(1) preparation of plant extraction liquid: the levant cotton exocarp of 65 parts by weight and the hemp seed and husk of 35 parts by weight are mixed, water floats
It washes, be ground into 120 mesh powders after 45-50 DEG C of drying, it is mixed that 8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕ 0.4 are added into gained powder
Bonding solvent refluxing extraction 15 minutes after impregnating 30 minutes, filters, discards filtrate, and 20 times of 7% ethyl alcohol of amount, leaching are added into filter residue
Bubble filters refluxing extraction 1 hour after 30 minutes, and filtrate decompression obtains plant extraction liquid after being concentrated 5 times；
(2) preparation of periploca spium leaf extract: by the rinsing of periploca spium leaf water, dry, 10 times of amounts 1.5% of addition after crushing carbonic acid
Hydrogen sodium water solution decocts 1 hour after impregnating 1 hour, filters, and filtrate is spare, and filter residue repeats to extract 1 time under the same conditions, closes
And filtrate, periploca spium leaf extract is obtained after gained filtrate decompression is concentrated 5 times；
(3) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts, 30 DEG C of immersion 1- being added into hydroxyethyl cellulose
2h is spare after being swollen it sufficiently；
(4) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, neural acyl
It is heated after amine, above-mentioned plant extraction liquid, above-mentioned periploca spium leaf extract, glycyrrhizic acid, glycerol, vitamin E, xanthan gum, boric acid mixing
It is mixed well to 70 DEG C of constant temperature stirring 15min, obtains mixed material；
(5) preparation of finished product: by said mixture material slow cooling to sequentially added after 30 DEG C thereto essence, pigment and
Chlorphenesin mixes well it in 30 DEG C of constant temperature stirring 10min, it then is added in the hydroxyethyl cellulose after above-mentioned swelling
In, 30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
Product quality is required with embodiment 1.
Comparative example 1
A kind of skin barrier maintenance biomembrane (compared with Example 1, not including plant extraction liquid in formula), is by following
Made of the raw material of parts by weight:
The preparation method is as follows:
(1) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts, 30 DEG C of immersion 1- being added into hydroxyethyl cellulose
2h is spare after being swollen it sufficiently；
(2) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, neural acyl
70 DEG C of constant temperature stirring 15min are heated to after amine, glycyrrhizic acid, glycerol, vitamin E, xanthan gum, boric acid mixing mixes well it,
Obtain mixed material；
(3) preparation of finished product: by said mixture material slow cooling to sequentially added after 30 DEG C thereto essence, pigment and
Chlorphenesin mixes well it in 30 DEG C of constant temperature stirring 10min, it then is added in the hydroxyethyl cellulose after above-mentioned swelling
In, 30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
Product quality is required with embodiment 1.
Comparative example 2
A kind of skin barrier maintenance biomembrane (the plant extraction liquid constituent compared with Example 1, in formula is different),
It is made of the raw material of following weight parts:
The preparation method is as follows:
(1) preparation of plant extraction liquid: will be ground into 120 mesh powders after the rinsing of levant cotton exocarp water, 45-50 DEG C of drying, to
8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕, 0.4 mixed solvents are added in gained powder, refluxing extraction 15 minutes after impregnating 30 minutes, take out
Filter, discards filtrate, and 20 times of 7% ethyl alcohol of amount are added into filter residue, refluxing extraction 1 hour after impregnating 30 minutes, filters, filtrate decompression
Plant extraction liquid is obtained after 5 times of concentration；
(2) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts, 30 DEG C of immersion 1- being added into hydroxyethyl cellulose
2h is spare after being swollen it sufficiently；
(3) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, neural acyl
70 DEG C of constant temperature stirrings are heated to after amine, above-mentioned plant extraction liquid, glycyrrhizic acid, glycerol, vitamin E, xanthan gum, boric acid mixing
15min mixes well it, obtains mixed material；
(4) preparation of finished product: by said mixture material slow cooling to sequentially added after 30 DEG C thereto essence, pigment and
Chlorphenesin mixes well it in 30 DEG C of constant temperature stirring 10min, it then is added in the hydroxyethyl cellulose after above-mentioned swelling
In, 30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
Product quality is required with embodiment 1.
Comparative example 3
A kind of skin barrier maintenance biomembrane (the plant extraction liquid constituent compared with Example 1, in formula is different),
It is made of the raw material of following weight parts:
The preparation method is as follows:
(1) preparation of plant extraction liquid: will be ground into 120 mesh powders after the rinsing of hemp seed and husk water, 45-50 DEG C of drying,
8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕, 0.4 mixed solvents are added into gained powder, refluxing extraction 15 minutes after impregnating 30 minutes,
It filters, discards filtrate, 20 times of 7% ethyl alcohol of amount are added into filter residue, refluxing extraction 1 hour after impregnating 30 minutes, filter, filtrate subtracts
Plant extraction liquid is obtained after 5 times of pressure concentration；
(2) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts, 30 DEG C of immersion 1- being added into hydroxyethyl cellulose
2h is spare after being swollen it sufficiently；
(3) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, neural acyl
70 DEG C of constant temperature stirrings are heated to after amine, above-mentioned plant extraction liquid, glycyrrhizic acid, glycerol, vitamin E, xanthan gum, boric acid mixing
15min mixes well it, obtains mixed material；
(4) preparation of finished product: by said mixture material slow cooling to sequentially added after 30 DEG C thereto essence, pigment and
Chlorphenesin mixes well it in 30 DEG C of constant temperature stirring 10min, it then is added in the hydroxyethyl cellulose after above-mentioned swelling
In, 30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
Product quality is required with embodiment 1.
Comparative example 4
A kind of skin barrier maintenance biomembrane (compared with Example 1, is formulated the preparation of plant extraction liquid in identical but formula
Method is different), be made of the raw material of following weight parts:
The preparation method is as follows:
(1) preparation of plant extraction liquid: the levant cotton exocarp of 65 parts by weight and the hemp seed and husk of 35 parts by weight are mixed, water floats
It washes, be ground into 120 mesh powders after 45-50 DEG C of drying, 20 times of 30% ethyl alcohol of amount are added into gained powder, after impregnating 30 minutes
It refluxing extraction 1 hour, filters, filtrate decompression obtains plant extraction liquid after being concentrated 5 times；
(2) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts, 30 DEG C of immersion 1- being added into hydroxyethyl cellulose
2h is spare after being swollen it sufficiently；
(3) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, neural acyl
70 DEG C of constant temperature stirrings are heated to after amine, above-mentioned plant extraction liquid, glycyrrhizic acid, glycerol, vitamin E, xanthan gum, boric acid mixing
15min mixes well it, obtains mixed material；
(4) preparation of finished product: by said mixture material slow cooling to sequentially added after 30 DEG C thereto essence, pigment and
Chlorphenesin mixes well it in 30 DEG C of constant temperature stirring 10min, it then is added in the hydroxyethyl cellulose after above-mentioned swelling
In, 30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
Product quality is required with embodiment 1.
Comparative example 5
A kind of skin barrier maintenance biomembrane (compared with Example 1, does not include plant extraction liquid, but hyalomitome in formula
Sour sodium additive amount is 10 times of 1 additive amount of embodiment), be made of the raw material of following weight parts:
The preparation method is as follows:
(1) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts, 30 DEG C of immersion 1- being added into hydroxyethyl cellulose
2h is spare after being swollen it sufficiently；
(2) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, neural acyl
70 DEG C of constant temperature stirring 15min are heated to after amine, glycyrrhizic acid, glycerol, vitamin E, xanthan gum, boric acid mixing mixes well it,
Obtain mixed material；
(3) preparation of finished product: by said mixture material slow cooling to sequentially added after 30 DEG C thereto essence, pigment and
Chlorphenesin mixes well it in 30 DEG C of constant temperature stirring 10min, it then is added in the hydroxyethyl cellulose after above-mentioned swelling
In, 30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
Product quality is required with embodiment 1.
Skin care moisturizing and improvement skin barrier function test
Moisturizing, skin bullet are carried out to skin barrier maintenance biomembrane prepared by 1-2 of the embodiment of the present invention and comparative example 1-5
Property, improve skin barrier function test.
[test object and grouping]
420 female subjects are chosen, the age 18-45 years old, are randomly divided into 7 groups, every group 60, respectively embodiment 1-2
Group and comparative example 1-5 group, each test group use corresponding biomembrane product, using it is preceding and continuous use 14 days after respectively carry out it is primary
Skin test.
[test index and test method]
Distilled water is dipped in clean cotton balls to scrub tested skin, and following test is carried out after drying 15 minutes:
(1) skin barrier function: refer to through transepidermal water loss value (Transepidermal Water Loss, TEWL)
The moisture evaporated by epidermis, TEWL are the important parameters for assessing skin barrier function, and skin barrier is more intact, and TEWL value is just
It is lower, biomembrane product can be evaluated to reparation effect of skin moisturizing barrier by measurement TEWL value.Utilize skin barrier ability
Tester (Tewameter TM300, CK) measures TEWL value.
(2) performance of keeping humidity of biomembrane product skin moisture content: can be evaluated by measurement skin moisture content.Utilize skin
Skin moisture tester (Corneometer CM825, CK) measures transepidermal water content.
(3) skin elasticity: the aging character of skin can be measured by measuring skin viscoelasticity, so as to for evaluating life
The skin-care effect of object film product.Skin viscoelasticity is measured using skin elasticity tester (Cutometer MPA580, CK).
These parameters test respectively carries out one before using skin barrier maintenance biomembrane and after continuous use biomembrane 14 days
Secondary, test need to select identical body region to carry out twice.After being completed, items before and after every subject's use are calculated
The situation of change of index value.
[test result]
Test result is as follows shown in table 2 (average value for taking each group subject's indices to change):
2 skin test result of table
Test result shows: after continuous use 14 days, the skin indices of each test group subject have in various degree
Improvement, in comparison, the moisturizing of 1-2 biomembrane of the embodiment of the present invention improves skin elasticity, improves skin barrier function effect
It is substantially better than the comparative example 1-5 product for changing composition of raw materials or preparation process, illustrates that 1-2 skin barrier of the embodiment of the present invention is repaired
Formula composition and the preparation method for protecting biomembrane are more reasonable compared with comparative example 1-5, biomembrane product skin care as made from it
It can be more superior.
The preferred embodiments of the disclosure and embodiment are explained in detail above, but the present invention is not limited to
The above-described embodiment and examples can also not depart from the present invention within the knowledge of those skilled in the art
Various changes can be made under the premise of design.
Claims (10)
1. a kind of skin barrier maintenance biomembrane, it is characterised in that it is made of the raw material of following weight parts:
2. skin barrier maintenance biomembrane as described in claim 1, it is characterised in that the plant extraction liquid for including in its raw material
It is made of the raw material of following weight parts:
Levant cotton exocarp 65；
Hemp seed and husk 35；
The preparation method is as follows:
120 mesh powders will be ground into after levant cotton exocarp and hemp seed and husk mixing, water rinsing, 45-50 DEG C of drying, into gained powder
8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕, 0.4 mixed solvents are added, refluxing extraction 15 minutes after impregnating 30 minutes, filters, discards filter
20 times of 7% ethyl alcohol of amount are added into filter residue for liquid, refluxing extraction 1 hour after impregnating 30 minutes, filter, after filtrate decompression is concentrated 5 times
Obtain plant extraction liquid.
3. skin barrier maintenance biomembrane as described in claim 1, it is characterised in that the moisturizer for including in its raw material is selected from
At least one of following compositions: glycerol, ethylene glycol, propylene glycol, sorbierite, more ethylene glycol.
4. skin barrier maintenance biomembrane as described in claim 1, it is characterised in that the preservative for including in its raw material is selected from
At least one of following compositions: p-hydroxybenzoate, parahydroxyacet-ophenone, cetyl dimethyl benzyl ammonium bromide, first
Base isothiazolinone, imidazolidinyl urea, phenoxetol, iodopropynyl butyl formate, bronopol, chlorobenzene are sweet
Ether.
5. skin barrier maintenance biomembrane as described in claim 1, it is characterised in that the skin barrier maintenance biomembrane warp
Following step is prepared:
(1) preparation of plant extraction liquid: levant cotton exocarp and hemp seed and husk are mixed, water rinses, is ground into 120 after 45-50 DEG C of drying
8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕, 0.4 mixed solvents are added into gained powder for mesh powder, flow back and mention after impregnating 30 minutes
It takes 15 minutes, filters, discard filtrate, 20 times of 7% ethyl alcohol of amount are added into filter residue, refluxing extraction 1 hour after impregnating 30 minutes, take out
Filter, filtrate decompression obtain plant extraction liquid after being concentrated 5 times；
(2) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts being added into hydroxyethyl cellulose, 30 DEG C of immersion 1-2h make
It is spare after being sufficiently swollen；
(3) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, ceramide, on
It states and is heated to 70 DEG C of constant temperature stirring 15min after plant extraction liquid, glycyrrhizic acid, moisturizer, vitamin E, xanthan gum, boric acid mixing and makes
It is mixed well, and obtains mixed material；
(4) preparation of finished product: by said mixture material slow cooling to sequentially adding essence, pigment and anti-corrosion thereto after 30 DEG C
Agent mixes well it in 30 DEG C of constant temperature stirring 10min, is then added thereto the hydroxyethyl cellulose after above-mentioned swelling,
30 DEG C of constant temperature homogeneous stir 30min to get skin barrier maintenance biomembrane finished product is arrived.
6. skin barrier maintenance biomembrane as described in claim 1, wherein the parts by weight of each raw material are:
Wherein the plant extraction liquid is made of the raw material of following weight parts:
Levant cotton exocarp 65；
Hemp seed and husk 35；
The preparation method is as follows:
120 mesh powders will be ground into after levant cotton exocarp and hemp seed and husk mixing, water rinsing, 45-50 DEG C of drying, into gained powder
8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕, 0.4 mixed solvents are added, refluxing extraction 15 minutes after impregnating 30 minutes, filters, discards filter
20 times of 7% ethyl alcohol of amount are added into filter residue for liquid, refluxing extraction 1 hour after impregnating 30 minutes, filter, after filtrate decompression is concentrated 5 times
Obtain plant extraction liquid；
The moisturizer is selected from least one of following compositions: glycerol, ethylene glycol, propylene glycol, sorbierite, more ethylene glycol；
The preservative is selected from least one of following compositions: p-hydroxybenzoate, parahydroxyacet-ophenone, cetyl two
Methylbenzyl ammonium bromide, methylisothiazolinone, imidazolidinyl urea, phenoxetol, iodopropynyl butyl formate, bromine
Nitre propylene glycol, Chlorphenesin.
7. skin barrier maintenance biomembrane as described in claim 1, it is characterised in that the skin barrier maintenance biology is made
The raw material of film further includes following weight parts:
Periploca spium leaf extract 3.9-4.5；
The periploca spium leaf extract is prepared through following methods: 10 times of amounts will be added after the rinsing of periploca spium leaf water, dry, crushing
1.5% sodium bicarbonate aqueous solution decocts 1 hour after impregnating 1 hour, filters, filtrate is spare, and filter residue repeats under the same conditions
It extracts 1 time, merging filtrate, periploca spium leaf extract is obtained after gained filtrate decompression is concentrated 5 times.
8. skin barrier maintenance biomembrane as claimed in claim 7, wherein the parts by weight of each raw material are:
9. skin barrier maintenance biomembrane as claimed in claim 7, it is characterised in that the skin barrier maintenance biomembrane warp
Following step is prepared:
(1) preparation of plant extraction liquid: levant cotton exocarp and hemp seed and husk are mixed, water rinses, is ground into 120 after 45-50 DEG C of drying
8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕, 0.4 mixed solvents are added into gained powder for mesh powder, flow back and mention after impregnating 30 minutes
It takes 15 minutes, filters, discard filtrate, 20 times of 7% ethyl alcohol of amount are added into filter residue, refluxing extraction 1 hour after impregnating 30 minutes, take out
Filter, filtrate decompression obtain plant extraction liquid after being concentrated 5 times；
(2) preparation of periploca spium leaf extract: by the rinsing of periploca spium leaf water, dry, 10 times of amounts 1.5% of addition after crushing sodium bicarbonate
Aqueous solution decocts 1 hour after impregnating 1 hour, filters, and filtrate is spare, and filter residue repeats to extract 1 time under the same conditions, merges filter
Liquid obtains periploca spium leaf extract after gained filtrate decompression is concentrated 5 times；
(3) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts being added into hydroxyethyl cellulose, 30 DEG C of immersion 1-2h make
It is spare after being sufficiently swollen；
(4) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, ceramide, on
70 are heated to after stating plant extraction liquid, above-mentioned periploca spium leaf extract, glycyrrhizic acid, moisturizer, vitamin E, xanthan gum, boric acid mixing
DEG C constant temperature stirring 15min mixes well it, obtains mixed material；
(5) preparation of finished product: by said mixture material slow cooling to sequentially adding essence, pigment and anti-corrosion thereto after 30 DEG C
Agent mixes well it in 30 DEG C of constant temperature stirring 10min, is then added thereto the hydroxyethyl cellulose after above-mentioned swelling,
30 DEG C of constant temperature homogeneous stir 30min to get skin barrier maintenance biomembrane finished product is arrived.
10. a kind of preparation method of skin barrier maintenance biomembrane, includes the following steps:
(1) composition of raw materials:
(2) preparation of plant extraction liquid: the levant cotton exocarp of 65 parts by weight and the hemp seed and husk of 35 parts by weight are mixed, water rinsing, 45-
120 mesh powders are ground into after 50 DEG C of drying, 8 times of amount Shi You Mi ﹕ hexamethylene=1 ﹕ 0.4 of addition are mixed molten into gained powder
Agent refluxing extraction 15 minutes after impregnating 30 minutes, filters, discards filtrate, 20 times of 7% ethyl alcohol of amount are added into filter residue, impregnates 30
It refluxing extraction 1 hour after minute, filters, filtrate decompression obtains plant extraction liquid after being concentrated 5 times；
(3) hydroxyethyl cellulose pre-processes: the deionized water of 50 times of amounts being added into hydroxyethyl cellulose, 30 DEG C of immersion 1-2h make
It is spare after being sufficiently swollen；
(4) preparation of mixed material: by deionized water, soybean protein isolate, triethanolamine, Sodium Hyaluronate, ceramide, on
It states and is heated to 70 DEG C of constant temperature stirring 15min after plant extraction liquid, glycyrrhizic acid, glycerol, vitamin E, xanthan gum, boric acid mixing and makes it
It mixes well, obtains mixed material；
(5) preparation of finished product: by said mixture material slow cooling to sequentially adding essence, pigment and chlorobenzene thereto after 30 DEG C
Sweet ether mixes well it in 30 DEG C of constant temperature stirring 10min, is then added thereto the hydroxyethyl cellulose after above-mentioned swelling,
30min are stirred in 30 DEG C of constant temperature homogeneous to get skin barrier maintenance biomembrane finished product is arrived.
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