CN106361595A - Zhiyan introduced solvent essence - Google Patents

Zhiyan introduced solvent essence Download PDF

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Publication number
CN106361595A
CN106361595A CN201610972861.5A CN201610972861A CN106361595A CN 106361595 A CN106361595 A CN 106361595A CN 201610972861 A CN201610972861 A CN 201610972861A CN 106361595 A CN106361595 A CN 106361595A
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Prior art keywords
solvent
skin
butanediol
essence
trehalose
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苏建华
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Beijing Acne Research Institute
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Beijing Acne Research Institute
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

Abstract

The invention belongs to muscle smoothing products in the field of cosmetics, and particularly relates to a Zhiyan introduced solvent essence. The Zhiyan introduced solvent essence comprises the following components in percentage by weight: 3-10% of carbomer, 4-10% of glycerol, 10-20% of glucan, 1-5% of palmitoyl kyrine-8, 1-3% of hydroxyethyl cellulose, 10-20% of trehalose, 2-10% of EDTA disodium, 2-8% of methylparaben, 1-4% of phenoxyethanol, 1-5% of butanediol, 2-7% of sodium hyaluronate, 2-6% of allantoin, 3-7% of triethanolamine and the balance of solvent. The solvent is preferably deionized water. The Zhiyan introduced solvent essence can effectively inhibit and treat acne, restore scars, fill up the skin and eliminate wrinkles. The Zhiyan introduced solvent essence can diminish inflammation, alleviate pains, remove skin darkness, flatten scars, clean pores, reduce the regeneration of acne, promote the skin cell metabolism, whiten the skin and rejuvenate the skin.

Description

A kind of intelligence is beautiful to import solvent essence
Technical field
The present invention relates to flat flesh product imports solvent essence and in particular to a kind of intelligence is beautiful in cosmetic field.
Background technology
Comedo, also known as acne, is a kind of pilosebaceous chronic inflammatory skin, is mainly apt to occur in teenager, right Teen-age psychology and social influence are very big, and clinical manifestation is to be apt to occur in the pleomorphism such as facial acne, pimple, pustule, tuberosity Skin lesion is feature, and the generation of facial comedo is main to be blocked with hypersteatosiss, pilosebaceous duct, bacterium infection and inflammation The factors such as disease reaction are closely related, and in the descendant's body that adolesces, the level of androgen particularly testosterone raises rapidly, promote Sebaceous gland is developed and is produced a large amount of sebums, and the dyskeratosis of pilosebaceous duct causes catheter blockage simultaneously, and barrier discharged by sebum Hinder, forming horn plug is micropowder thorn, multiple-microorganism especially propionibacterium acness amount reproduction, propionibacterium acness in hair follicle The lipase producing decomposes sebum and generates free fatty, chemotactic inflammatory cell and medium simultaneously, finally induces and to increase inflammation anti- Should.
Comedo treatment at present is broadly divided into western medical treatment, Chinese traditional treatment and laser therapy, and western medical treatment includes taking one A little antibiotic or the such as hormone medicine such as gonadal hormone, Progesterone are treated, the onset in a short time of this kind of method, but take these Medicine is easily caused endocrine disturbance, and impact is healthy.Treatment by Chinese herbs is to be nursed one's health by taking Chinese medicine, and shortcoming is to take effect Slowly, and it is impossible to distinguish formula one by one for different people body constitution based on taking good care of.Although laser anti-acne can kill causes the youth The Propiobacterium of pox, but the rotten greatly pox for very deep layer, very big is ineffective, postoperative face is it is possible that uneven The uneven phenomenon of skin, and also need to long time recover.
Acne skin mostly is sensitive skin, and profit is unbalance, if again through improperly treating, skin can be led to be badly damaged, Skin redness pustule occurs, uneven, the colour of skin is dim, lackluster, microgroove and fold.And for these impaired fleshes Skin, if being treated with conventional product for resolving poxes again, can increase the burden of skin, leading to skin problem further to deteriorate. And repair in product, can not effectively be directed to acne skin again, both prevent and treat acne, and impaired rear acne skin can be repaired, Single go scar product repairing effect not good it is also possible to lead to that skin profit is unbalance to become estranged again, increase acne problems.
At present, the anti-acne on market repairs product, and function is all very single, or only has cicatrix effect, or only dispels Pox effect, or only wrinkle removing effect, or only white-skinned face function, and the facial problem that a lot of patients with acne needs solve is multiple many Sample, especially long-term patients with acne, its skin is uneven, needs to fill and lead up and repair, also simultaneously need to preventing and treating Cuo Skin ulcer, removes obscure, skin whitening, smoothes away wrinkles.So one kind has anti-acne, scar of dispelling, smooth skin, wrinkle reduction, whitening flesh Many effects product of skin and will be expected required for vast patients with acne.
Content of the invention
For above-mentioned weak point of the prior art, the invention provides a kind of intelligence is beautiful imports solvent essence, this Bright can effectively press down pox treatment of smallpox, repair cicatrix, fill and lead up skin, smooth away wrinkles;Can anti-inflammatory analgetic, remove obscure, calm down cicatrix, Unclogging, reduces acne regeneration, promotes skin cell metabolism, skin whitening, makes skin shining gloss again.
A kind of intelligence is beautiful to import solvent essence, comprising:
Carbomer, glycerol, glucosan, palmityl tripeptides -8, hydroxyethyl cellulose, trehalose, edta disodium, oxybenzene first Ester, phenoxyethanol, butanediol, hyaluronate sodium, allantoin and triethanolamine, above-mentioned composition by weight percentage, respectively 3%-10%, 4%-10%, 10%-20%, 1%-5%, 1%-3%, 10%-20%, 2%-10%, 2%-8%, 1%- 4%th, 1%-5%, 2%-7%, 2%-6%, 3%-7%;Remaining is solvent.
Further, described Carbomer, glycerol, glucosan, palmityl tripeptides -8, hydroxyethyl cellulose, trehalose, edta The ratio by mass percentage ratio of disodium, methyl hydroxybenzoate, phenoxyethanol, butanediol, hyaluronate sodium, allantoin and triethanolamine Meter, preferably 4%-8%, 5%-8%, 12%-18%, 2%-4%, 2%-3%, 13%-16%, 3%-7%, 3%-7%, 2%-4%, 2%-4%, 3%-6%, 3%-6%, 4%-7%;Remaining is solvent.
Further, described Carbomer, glycerol, glucosan, palmityl tripeptides -8, hydroxyethyl cellulose, trehalose, edta The ratio by mass percentage ratio of disodium, methyl hydroxybenzoate, phenoxyethanol, butanediol, hyaluronate sodium, allantoin and triethanolamine Meter, preferably 5%, 7%, 15%, 3%, 2%, 15%, 5%, 5%, 3%, 3%, 5%, 5%, 5%;Remaining is solvent.
Further, described solvent is water, preferably deionized water.
Further, described butanediol comprises 1,2- butanediol, 1,3 butylene glycol, BDO or 2,3-butanediol; Preferably 1,3 butylene glycol.
Further, the preferred beta glucan of described glucosan.
Further, described trehalose preferred α, β-trehalose.
Wherein, described Carbomer (carbomer), this product is bonded allyl sucrose or tetramethylolmethane allyl ether for acrylic acid High molecular polymer.Calculate by dry product, (cooh) containing carboxylic acid group should be 56.0%~68.0%.This product is white loose Sprills;Micro- smelly;Have draw moist.Carbomer is the acrylic acid crosslinked resin being obtained with acrylic acid crosslinking with tetramethylolmethane etc., is The very important rheology control agent of one class, the Carbomer after neutralization is outstanding gel-type vehicle, has the important use such as thickening, suspension On the way, process is simple, good stability, be widely used in emulsion, cream, in gel.Carbomer is often used as emulsifying agent, can be in room temperature Wax is melted, emulsifiable wax class, can give full play to the profit of surfactant by emulsified any liquid oils in the fabrication process The effects such as wet, dispersion, adhesion, can be obtained stable Emulsion, again during moistening will not reemulsification, easily preparation is without film former Waterproofing emulsion, can make high oil phase dissolve in formation (o/w) Emulsion in water, can prepare: moist cream, emulsion, face cleaning product, sun-proof product Product, no alcohol perfume, essence conditioner (strengthen gloss it is easy to combing), hand lotion, the low sprayable Emulsion of denseness and transparent microemulsion Liquid etc..Carbomer is also used in skin care item, hydrophilic thickening agent, stabilising emulsifier, suspending agent, gel, have good it Transparency, just has denseness to alkalescence in need to maintaining, so with acids skin-active composition and cannot deposit, Carbomer is also afraid of salt in addition Class, therefore mineral ion cannot be added, otherwise denseness will disappear, and has zest to eye mucosa.High molecular polymer, after connect Numeral is bigger, and to represent polymerizable molecular bigger.
Wherein, described glycerol is also known as Glycerin, glycerol (glycerol, glycerine), chemical formula c3h8o3, Glycerol is colourless, taste is sweet, clear and bright thick liquid, and odorless has warm sweet taste.National standard is referred to as glycerol, can absorb from the air Moisture, also can absorb hydrogen sulfide, Blausure (German) and sulfur dioxide.Be insoluble in benzene, chloroform, carbon tetrachloride, Carbon bisulfide, petroleum ether and Oils.Glycerol is the framework ingredient of triglyceride molecule.When human body takes in edible fat, triglyceride therein is through body Intracellular metabolite decomposes, and forms glycerol and is stored in adipose cell.Therefore, the final product of Triglyceride Metabolism in Patients is glycerol and fat Fat acid.Can be used as solvent, lubricant, medicament and sweeting agent.The analysis, solvent, gasometer and the hydraulic press that are applied to aqueous solution delay Shake liquid, softening agent, antibiotic fermentation nutrient, desiccant, lubricant, pharmaceuticals industry, cosmetic formulations, organic synthesiss, mould Agent.Can dissolve in any proportion with water, low concentration glycerin solution can do lubricating oil and skin is moistened.Biology is refined sweet Oil is top quality one kind in food grade glycerol, and except containing glycerol, also the reducing sugar such as esters, glucose, belongs to polyhydric alcohol Class glycerol;In addition to there is moisturizing, the foster function of profit, also there is high activity, antioxidation, promote the special efficacies such as alcoholization.
Wherein, described glucosan (dextran or glucan) also known as dextran, molecular formula is [c6h10o5]n.Glucosan Refer to the homotype polysaccharide forming with glucose for monosaccharide, bonded with glucosides between glucose unit.Wherein according to glycosidic bond Type can be divided into alpha- glucosan and beta- glucosan again.Study in alpha- glucosan and using more be Dextran, is a kind of polysaccharide.It is present in the mucus that certain micro-organisms is secreted in growth course.Glucosan has higher Molecular weight, mainly by d- glucopyanosyl with α, 1-6 is bonded, and side chain point has 1-2,1-3,1-4 to connect.With microbial species Class and the difference of growth conditionss, its structure also has difference.Glucosan has high specific rotatory power;Partial hydrolysiss mainly obtain different wheat Bud sugar.Glucosan can replace a part of whole blood in transfusion procedure, as the expansion agent of Plasma volumes, referred to as plasma substitute.Commodity Blood plasma substitute is the glucosan after partial hydrolysiss, is dissolved in normal saline.Beta glucan active structure is by glucose unit group The polysaccharide becoming, their great majority pass through β -1,3 combinations, and this is the mode that Fructus Vitis viniferae sugar chain connects.It can activated macrophage, Neutrophils etc., therefore can improve the content of leukin, the basic element of cell division and distinct antibodies, stimulate exempting from of body comprehensively Epidemic disease system.Allow body to have more and be ready to resist the disease that microorganism causes.Beta glucan can make the lymph of injured body thin The rapid recovery of ability that born of the same parents produce cytokine il-1 is normal, effectively adjusts human body immune function.
Wherein, described palmityl tripeptides -8 (neutrazen, palmitoyl tripeptide-8), are a kind of artificial conjunctions Become polypeptide, white powder, for alleviating skin allergy discomfort.
Wherein, described hydroxyethyl cellulose (hec, hydroxyethyl cellulose), chemical formula c2h6o2X, also known as 2- hydroxyethyl ether cellulose, 2- hydroxyethyl cellulose, hydrogen-oxygen ethyl cellulose, natrosol.Hydroxyethyl cellulose is A kind of white or faint yellow, tasteless, nontoxic threadiness or pulverulent solids, by alkali cellulose and oxirane (or chloroethene Alcohol) etherified reaction preparation, belong to nonionic soluble fiber element ethers.Hec have good thickening, suspension, dispersion, emulsifying, The characteristics such as bonding, film forming, protection moisture and offer protecting colloid, have been widely used in oil exploitation, coating, building, medicine The fields such as food, weaving, papermaking and macromolecular polymerization reaction.Make surfactant, colloid protective agent, vinyl chloride, acetic acid second The emulsions such as alkene take the emulsion stabilizer sharing, and the viscosifier of latex, dispersant, dispersion stabilizer etc., are widely used in applying The aspects such as material, fiber, dyeing, papermaking, cosmetics, medicine, pesticide.
Wherein, described trehalose is also known as Radix Rhapontici sugar, gill fungus sugar etc..It is a kind of safe and reliable natural saccharide.Trehalose be by The nonreducing sugar that two glucose molecules are constituted with 1,1- glycosidic bond, has 3 kinds of isomers to be trehalose (α, α), isotrehalose (β, β) and neotrehalose (α, β), and there is non-specific protective effect to various bioactivators.Trehalose is in nature All be widely present in middle many edible animals and plants and microbial body, such as edible in people's daily life mushroom class, seaweeds, There is the higher trehalose of content in beans, shrimp, bread, medicated beer and yeast fermented food.Trehalose has mystery to organism Protective effect, be because that trehalose in high temperature, high and cold, hyperosmosises and is dried under the severe environmental conditions such as dehydration in cell table Face can form the protecting film of uniqueness, effectively protected protein matter molecule invariance inactivation, thus the life process of the body that sustains life And biological characteristic.Many adverse circumstances to external world show the species of outstanding degeneration-resistant tolerance, all big with their internal presence The trehalose of amount has direct relation.And saccharides as other in sucrose, glucose etc. in nature, all do not possess this function.This The functional characteristic of one uniqueness is so that trehalose is except can be excellent as pharmaceutical grade protein, enzyme, vaccine and other biological product Beyond activity protecting agent, be also to maintain cytoactive, the important component of moisturizing class cosmetics, more can as prevent food deterioration, Keep food fresh flavor, the particular foodstuff dispensing of lifting food quality, significantly expand trehalose as natural edible sweet taste The function of sugar.
Wherein, described edta disodium (ethylenediaminetetraacetic acid disodium salt), also known as Disodiumedetate, disodium EDTA, edta disodium, edta disodium salt, pt.Molecular formula: c10h14n2na2o8·2h2o.White crystalline powder.The salt apoplexy due to endogenous wind of ethylenediaminetetraacetic acid, disodium salt is mostly important, is a kind of weight Want chelating agent, for complexation of metal ions and separation metal it can also be used to detergent, liquid soaps, shampoo, agriculture chemistry spray Mist agent, color sensitive material washing processing bleach-fixing liquid, water purification agent, ph regulator, anticoagulant etc..It is polymerized in butadiene-styrene rubber and use In redox system, edta disodium, as the ingredient of activating agent, is mainly used in complexation ferrous ion, controls polymerization Response speed.This product also serves as the chelating agen for metal ion.Inspection calcium, magnesium etc..For pharmaceuticals industry, colour development, rare The fields such as the smelting of metal, are a kind of important chelating agent and metal shadowing agent.For measuring calcium, magnesium and other metals.It is used as Metal shadowing agent, color developer.It is also used for pharmaceuticals industry and the smelting of rare metal.Also serve as cosmetics antioxidant synergist, Belong to metal ion chelation agent, with edta, there is identical effect, but range of application is wider.Trace meter is contained in cosmetic material In ion and Cosmetic Manufacture, transporting procedures, the occasion using canister all can use.
Wherein, described methyl hydroxybenzoate (methylparaben) also known as methyl parahydroxybenzoate, chemical formula c8h8o3, white Crystalline powder or colourless crystallization, are soluble in alcohol, ether and acetone, atomic are dissolved in water.Be mainly used as organic synthesiss, food, cosmetics, The sterilization antiseptic of medicine, also serves as in feed anticorrosion agent.Be mainly used as organic synthesiss, food, cosmetics, medicine sterilization prevent Rotten agent, also serves as in feed anticorrosion agent.Pharmaceutic adjuvant, preservative.Methyl hydroxybenzoate is the broad spectrum activity efficient food generally acknowledged in the world Preservative, the state such as the U.S., Europe, Japan, Canada, Korea S, Russia all allows methyl hydroxybenzoate to apply in food.Extensive It is applied to the fields such as the flavoring agent such as soy sauce, vinegar, curing food, bakery, jam product, beverage, yellow wine and preserving fruit and vegetable utilizing.Oxybenzene Methyl ester class comprises methyl hydroxybenzoate, oxybenzene methyl ethyl ester, oxybenzene first propyl ester, oxybenzene first butyl ester, oxybenzene first monooctyl ester and oxybenzene first methyl ester Sodium, oxybenzene methyl ethyl ester sodium, oxybenzene first propyl ester sodium, oxybenzene first butyl ester sodium salt and compound methyl hydroxybenzoate sodium, according to physicochemical characteristic Different application is anti-corrosion in food, medicine, organic synthesiss and other industry.
Wherein, described phenoxyethanol (phenoxyaethanolum) also known as p-phenoxyethyl alcohol, ethylene glycol Phenylate, two phenyl phenol, phenyl phenol, chemical formula c8h10o2, phenoxyethanol belongs to organic synthesiss thing, is colourless slightly band viscosity Liquid, micro-perfume, puckery.Water insoluble, arbitrarily can mix with acetone, ethanol and glycerol.It is slightly soluble in water, be common in cosmetics Preservative, belongs to one of relatively safe preservative, restriction concentration in cosmetics for the phenyl phenol is up to 1%., solution is 0.1%-2% (wherein plus ethanol 10%).Phenoxyethanol, can be used as fixative in perfume, can make anthelmintic Agent, disinfectant for external use, the solvent of cellulose acetate, dyestuff, ink, resin, preservative and other medical usages.Additionally, also It is used as the anesthetis of Fish in culture fishery.Also multiple U.S. vaccine is classified as by disease prevention and control center of the U.S. One of composition.
Wherein, described butanediol (butanediol) has multiple isomerss, outside this 1,2- butanediol, also 1,3 butylene glycol, BDO, 2,3-butanediol.1,2- butanediol is a kind of chemicals, abbreviation bd, and appearance colorless is transparent, Molecular formula c4h10o2, it is mainly used in organic synthesiss, preparation 2- amino butanol etc..
Wherein, described hyaluronate sodium (sodium hyaluronate) also known as Sodium Hyaluronate, hyaluronic acid sodium, alduronic acid Sodium, glass (alditol) acid, love dimension, Hialid etc..Hyaluronate sodium is a kind of biochemical drug with higher clinical value, extensively should For all kinds of ophthalmologic operations, such as Lens implantation, corneal transplantation and resisting glaucoma operation etc..Can be additionally used in treatment of arthritis and acceleration Wound healing.Use it in cosmetics, the protection skin effect of uniqueness can be played, skin moisturizing can be kept smooth, fine and smooth soft Tender, high resilience, the effect that there is wrinkle resistant, crease-resistant, aesthetic health care and recover skin physiology function.Can be used for cosmetics cream, In the product such as frost, honey, milk, facial film, shampoo, to keep the moisture of skin, hair, skin care, hair, increase gloss, and The generation of chapped skin and wrinkle can be prevented.Also can treatment of arthritis and accelerating wound healing.
Wherein, described allantoin (allantoin) also known as Allantoin, Allantoin, Allantion, Allantoin, n- (2,5- dioxo -4- imidazoline piperidinyl) carbamide, are a kind of hydantoin derivatives.Molecular formula c4h6o3n4.White crystalline powder, odorless tasteless.At medical aspect: allantoin has promotion cell growth, accelerate wound healing, The physiological functions such as horny layer softening albumen, are good consolidant and the antiulcer agents of skin trauma.Can be used as alleviating and treat skin Skin xerosises, scaling dermatopathy, skin ulcer, digestive tract ulcer and inflammation, to osteomyelitis, diabetes, liver cirrhosis, acne All there is good therapeutic effect.In terms of cosmetics: because allantoin is a kind of amphoteric compound, double salt can be formed in conjunction with many kinds of substance, There is lucifuge, sterilization and anticorrosion, pain relieving, antioxidation, skin can be made to keep moisture, moisten and soft, be that cosmetology etc. is changed The additive of cosmetic, be widely used in freckle cream, anti-acne toner, shampoo, fancy soap, toothpaste, shaving lotion, conditioner, astringent, The additive of anti-antiperspirant deodorization lotion etc..Add allantoin cosmetics have protective tissue, hydrophilic, absorb water and prevent moisture from distributing Deng effect;Add the suppurative mastitis of allantoin, hair cream, shampoo, have protective effect to hair, can make hair not bifurcated, constantly send out;Add Plus the lip pomade of allantoin, facial cream can make skin, lip soft and high resilience, and have the gloss of beauty.Allantoin promotion organization Growth, cell metabolism, horny layer softening layer albumen.Agriculturally: allantoin is excellent plant growth regulator, can stimulate Plant growing, all has notable effect of increasing production to Semen Tritici aestivi, mandarin orange, Oryza sativa L., vegetable, Semen sojae atricolor etc., and has solid fruit, precocious effect.
Wherein, described triethanolamine tris (2-hydroxyethyl) amine also known as: 2,2 ', 2 "-nitrilotriethanol, 2,2 ', 2 "-Triaethanolamine, Triaethanolamine, industrial triethanolamine, triethanolamine, triethanolamine, three (2- ethoxys) Amine, Triaethanolamine.The trihydroxy substituent of triethylamine can be regarded as.Similar to other aminated compoundss, due to nitrogen-atoms On there are lone pair electrons, triethanolamine has alkalescence, can generate salt with mineral acid or organic acid reaction.Chemical formula (hoch2ch2)3n.Colourless to pale yellow transparent thick liquid, micro- have ammonia taste, becomes colourless to faint yellow cubic system during low temperature Crystal.Soluble in water, ethanol, acetone, glycerol and ethylene glycol etc., are slightly soluble in benzene, ether and carbon tetrachloride etc., in non-polar solven In almost do not dissolve.It is used as emulsifying agent, wetting agent, increasing in cosmetics (including skin washing, eye glue, moisturizing, shampoo etc.) Humectant, thickening agent, ph poising agent.Cosmetic formulations are used for in fatty acid and become soap, and in sulfated fatty acid and become Amine salt.Triethanolamine is to commonly use emulsifying agent in cream preparation, has mastic exquisiteness, mastic with the cream products of triethanolamine emulsifying The feature of brilliant white, the gel phase good stability that another triethanolamine is formed with higher fatty acids or high fatty alcohol, product quality is steady Fixed, additional ingredients proportion can be held high.Triethanolamine is the most frequently used nertralizer containing the acidity high-molecular gel such as Carbomer, three second Hydramine, by being neutralized with carboxyls such as Carbomer, is formed stable macromolecular structure, reaches the effect of thickening and moisturizing.Wash in liquid Wash in agent addition triethanolamine, can improve oily dirt, the removal of particularly nonpolar sebum, meanwhile, can by improving alkalescence Improve detergency ability.And there is its fabulous compatibility.Also act as lubricating oil and anticorrosive additive etc..The length of triethanolamine Chain fatty hydrochlorate is in weakly acidic pH, can be used as the emulsifying agent of oils and fatss and wax.As complexometric reagent aluminum ions in solution, this reaction Typically carrying out complexometry with another kind of chelate (if forming the edta of stable comple with most metal ions) Before, for by the specific ion " sheltering " in solution.Highly effective chelating agent as each heavy metal species.In alkaline zincate galvanizing In can with zinc complexation, improve plating solution cathodic polarization effect, make coating crystallize careful, content is higher to reduce deposition velocity, low Then can make that coating burnt hair is coarse, dispersion force is poor.But the viscosity of triethanolamine is big, so that the electric current density upper limit of plating solution is reduced.For It is good solvent in textile industry, hygroscopic agent.It is the raw material of fabric softener.As industrial gas purifying agent, at waste gas It is used as in reason to remove the sour gas such as hydrogen sulfide and carbon dioxide.As plasticizer, nertralizer, lubricant additive or anti-corrosion The dispersant of erosion agent and dyestuff, resin etc..Also act as synthetic surfactant, stabilizer.
Using technique scheme, the present invention includes following Advantageous Effects:
The present invention can effectively press down pox treatment of smallpox, repair cicatrix, fill and lead up skin, smooth away wrinkles;Can anti-inflammatory analgetic, remove dark Heavy, calm down cicatrix, unclogging, reduce acne regeneration, promote skin cell metabolism, skin whitening, make skin shining gloss again.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail.
The invention provides a kind of intelligence is beautiful imports solvent essence, comprising:
Carbomer, glycerol, glucosan, palmityl tripeptides -8, hydroxyethyl cellulose, trehalose, edta disodium, oxybenzene first Ester, phenoxyethanol, butanediol, hyaluronate sodium, allantoin and triethanolamine, above-mentioned composition by weight percentage, respectively 3%-10%, 4%-10%, 10%-20%, 1%-5%, 1%-3%, 10%-20%, 2%-10%, 2%-8%, 1%- 4%th, 1%-5%, 2%-7%, 2%-6%, 3%-7%;Remaining is solvent;Solvent is water or deionized water.
It is further preferred that described Carbomer, glycerol, glucosan, palmityl tripeptides -8, hydroxyethyl cellulose, trehalose, The ratio by mass percentage of edta disodium, methyl hydroxybenzoate, phenoxyethanol, butanediol, hyaluronate sodium, allantoin and triethanolamine Ratio meter, preferably 4%-8%, 5%-8%, 12%-18%, 2%-4%, 2%-3%, 13%-16%, 3%-7%, 3%- 7%th, 2%-4%, 2%-4%, 3%-6%, 3%-6%, 4%-7%;Remaining is solvent;Solvent is water or deionized water.
It is further preferred that described Carbomer, glycerol, glucosan, palmityl tripeptides -8, hydroxyethyl cellulose, Sargassum Sugar, edta disodium, methyl hydroxybenzoate, phenoxyethanol, butanediol, the ratio by mass of hyaluronate sodium, allantoin and triethanolamine Percentages, preferably 5%, 7%, 15%, 3%, 2%, 15%, 5%, 5%, 3%, 3%, 5%, 5%, 5%;Remaining is molten Agent;Solvent is water or deionized water.
In specific embodiment, above-mentioned recipe ingredient ratio is as shown in table 1 below:
Table 1. inventive formulation component proportion ratio table
It is further preferred that described butanediol comprises 1,2- butanediol, 1,3 butylene glycol, BDO or 2,3- fourth Glycol;Preferably 1,3 butylene glycol.
It is further preferred that described glucosan is beta glucan.
It is further preferred that described trehalose is α, β-trehalose.
The above embodiment of the present invention can effectively press down pox treatment of smallpox, repair cicatrix, fill and lead up skin, smooth away wrinkles;Being capable of antiinflammatory Pain relieving, removes obscure, calms down cicatrix, unclogging, reduces acne regeneration, promotes skin cell metabolism, skin whitening, make skin Shine gloss again.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for the skill of this area For art personnel, the present invention can have various modifications and variations.All within the spirit and principles in the present invention, made any repair Change, equivalent, improvement etc., should be included within the scope of the present invention.

Claims (8)

1. a kind of intelligence is beautiful imports solvent essence it is characterised in that including: Carbomer, glycerol, glucosan, palmityl tripeptides -8, Hydroxyethyl cellulose, trehalose, edta disodium, methyl hydroxybenzoate, phenoxyethanol, butanediol, hyaluronate sodium, allantoin and three second Hydramine, above-mentioned composition by weight percentage, respectively 3%-10%, 4%-10%, 10%-20%, 1%-5%, 1%- 3%th, 10%-20%, 2%-10%, 2%-8%, 1%-4%, 1%-5%, 2%-7%, 2%-6%, 3%-7%;Remaining is Solvent.
2. intelligence according to claim 1 is beautiful imports solvent essence it is characterised in that described Carbomer, glycerol, Portugal are gathered Sugar, palmityl tripeptides -8, hydroxyethyl cellulose, trehalose, edta disodium, methyl hydroxybenzoate, phenoxyethanol, butanediol, hyalomitome The ratio by mass percentages of sour sodium, allantoin and triethanolamine, preferably 4%-8%, 5%-8%, 12%-18%, 2%-4%, 2%-3%, 13%-16%, 3%-7%, 3%-7%, 2%-4%, 2%-4%, 3%-6%, 3%-6%, 4%-7%;Remaining is solvent.
3. intelligence according to claim 2 is beautiful imports solvent essence it is characterised in that described Carbomer, glycerol, Portugal are gathered Sugar, palmityl tripeptides -8, hydroxyethyl cellulose, trehalose, edta disodium, methyl hydroxybenzoate, phenoxyethanol, butanediol, hyalomitome The ratio by mass percentages of sour sodium, allantoin and triethanolamine, preferably 5%, 7%, 15%, 3%, 2%, 15%, 5%th, 5%, 3%, 3%, 5%, 5%, 5%;Remaining is solvent.
4. according to the arbitrary described intelligence of claim 1-3 beautiful importing solvent essence it is characterised in that described solvent is water, excellent Select deionized water.
5. according to the arbitrary described intelligence of claim 1-3 beautiful import solvent essence it is characterised in that the preferred β of described glucosan- Glucosan.
6. according to the beautiful solvent essence that imports of the arbitrary described intelligence of claim 1-3 it is characterised in that the preferred α of described trehalose, β-trehalose.
7. according to the beautiful solvent essence that imports of the arbitrary described intelligence of claim 1-3 it is characterised in that described butanediol comprises 1, 2- butanediol, 1,3 butylene glycol, BDO or 2,3-butanediol.
8. intelligence according to claim 7 is beautiful imports solvent essence it is characterised in that described butanediol preferably 1,3- fourth two Alcohol.
CN201610972861.5A 2016-11-07 2016-11-07 Zhiyan introduced solvent essence Pending CN106361595A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107028830A (en) * 2017-04-25 2017-08-11 徐子雁 It is a kind of to prevent the medicine and its preparation technology of scar hyperplasia
CN110507599A (en) * 2019-09-24 2019-11-29 山东甲骨文生物科技有限公司 A kind of preparation method containing the facial mask essence of cell extract and the cell extract
CN112294718A (en) * 2020-10-14 2021-02-02 广州悦瑞生物科技有限公司 Brightening and skin-refreshing essence and preparation method and application thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107028830A (en) * 2017-04-25 2017-08-11 徐子雁 It is a kind of to prevent the medicine and its preparation technology of scar hyperplasia
CN107028830B (en) * 2017-04-25 2021-03-09 徐子雁 Medicine for preventing scar hyperplasia and preparation process thereof
CN110507599A (en) * 2019-09-24 2019-11-29 山东甲骨文生物科技有限公司 A kind of preparation method containing the facial mask essence of cell extract and the cell extract
CN112294718A (en) * 2020-10-14 2021-02-02 广州悦瑞生物科技有限公司 Brightening and skin-refreshing essence and preparation method and application thereof

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