CN110464672A - A kind of cosmetic composition with safe antioxidant effect - Google Patents
A kind of cosmetic composition with safe antioxidant effect Download PDFInfo
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- CN110464672A CN110464672A CN201910846557.XA CN201910846557A CN110464672A CN 110464672 A CN110464672 A CN 110464672A CN 201910846557 A CN201910846557 A CN 201910846557A CN 110464672 A CN110464672 A CN 110464672A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses a kind of cosmetic compositions with safe antioxidant effect.By weight percentage, the raw material components that the cosmetic composition includes have: small molecule hydrolyzes Sodium Hyaluronate 0.02-1.0%, Delta-Tocopherol 0.02-1.0%, Mi Luomu leaf/stem extraction 0.1-3.0%, grape fruit cell extract 0.1-2.5%, cosmetic matrix 92.5-99.76%.Antioxidant composition of the present invention is to hydrolyze Sodium Hyaluronate, Delta-Tocopherol, grape fruit cell extract, Mi Luomu leaf/four kinds of stem extraction material composition by small molecule, four kinds of substances complement each other, the addition of especially appropriate grape fruit cell extract can reach the safe antioxidant effect of skin care item to reducing cytotoxicity and improving the effect of composition oxidation resistance obviously.
Description
Technical field
The present invention relates to a kind of skin-protection products, belong to Cosmetic Manufacture technical field, have safety more particularly to one kind
Cosmetic composition of antioxidant effect and preparation method thereof.
Background technique
With urban development, air pollution, the aggravation of PM2.5 and solar ulatraviolet radiation, human skin is easy because exposing
A large amount of free radicals such as reveal and generate nitrogen, sulphur, oxygen, causes the structures such as cell, albumen to destroy, and cannot repair.So that people
The decline of body immunity function, also there is the phenomenon that dim mute, loose, sensitive, wrinkle waited presenility in human skin, for skin antioxygen
The demand of change is also higher and higher with regard to more and more.
Currently, there are some one-sidedness more in oxidation resistant cosmetics:
1) be much using the single substance with reproducibility, but its specific inoxidizability on earth how, do not have
Actual test is not comprehensive enough；
2) some be using a variety of reducing substances, but or be no concertedness, only simply combine or be
Concertedness is experiments have shown that deficiency；
3) there are stability problem, discoloration problems for antioxidation cosmetic product；
4) in antioxidation cosmetic product the dosage of antioxidant be not it is The more the better, some substances can play instead after adding
Negative effect；
5) many antioxidation cosmetic product do not consider that skin environment has water also to have lipid, and the selection of antioxidant also needs
Consider the balance of grease phase partitioning.
Currently, material composition or the not comprehensive enough or safety of effect be not high on the market；So, it develops a kind of real
The antioxidant composition of safety is necessary.
Summary of the invention
In order to overcome defect existing for existing antioxidation cosmetic product and existing deficiency, the object of the present invention is to provide one kind
It can safe skin care；There is the cosmetic composition of antioxidant effect again.
The present invention a kind of cosmetic composition with safe antioxidant effect to be provided, by being technical side as follows
What case was achieved.
A kind of cosmetic composition with safe antioxidant effect, the composition include following mass percent group
Point:
Small molecule hydrolyzes Sodium Hyaluronate 0.02-1.0%；Delta-Tocopherol 0.02-1.0%；Close Luo Mu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extraction 0.1-3.0%；Grape (VITIS VINIFERA) fruit cell extract 0.1-2.5%；
Cosmetic matrix 92.5-99.76%.
Combining this that there is the cosmetic composition of safe antioxidant effect to test the best safe antioxidant effect of sample-
On the basis of cosmetic compositions B, in conjunction with the particularity that cost factor and each component are played a role, while considering in this composition group
Dividing still has antioxidant effect under safe concentration, establish preferably, the present invention has the cosmetic combinations of safe antioxidant effect
Object, the raw material components comprising following mass percent:
Furthermore, the present invention has the cosmetic composition of safe antioxidant effect, includes following mass percent
Raw material components:
Furthermore, the small molecule hydrolyzes Sodium Hyaluronate, small molecule hydrolyze Sodium Hyaluronate molecular weight be≤
10000Da。
Preferably, the molecular weight of the small molecule hydrolysis Sodium Hyaluronate is≤5000Da, about 3000Da or so.
Preferably, the cosmetic matrix includes solvent, moisturizer, chelating agent, emollient, skin conditioning agent, cream
One of agent, solubilizer, aromatic, preservative, thickener, PH regulator are a variety of.
Preferably, the solvent is in water, propylene glycol, methyl propanediol, dipropylene glycol, pentanediol, isoprene
It is in one or a variety of；
The moisturizer is selected from one of glycerol, polyglyceryl ether -26, butanediol, polyglycereol -6,1,3-PD or more
Kind；
The chelating agent is selected from one of EDTA-2Na, EDTA-3Na, decoyl hydroximic acid or a variety of；
The skin conditioning agent is selected from plant extracts, plant callus extract, tunning, small molecule plant egg
One of bletilla peptides are a variety of；
The emollient is selected from silicone oil and Synthetic Oil, vegetable fat etc.
The emulsifier is selected from glycoside, sucrose ester, amino acids, glyceride type and polyglycereol esters, polyethylene glycol
One of class nonionic is a variety of；
The aromatic is selected from natural extraction plants essential oil, the synthesis fragrance of a flower, synthesis fruity or compound flower fruity etc.；
The preservative is selected from Phenoxyethanol, parabens, benzoic acid and its esters, dehydroactic acid and its esters, double
Sodium acetate etc.；
The thickener is selected from xanthan gum, carragheen, carbomer, high molecular cellulose, Sodium Polyacrylate, acrylic acid (ester)
Analog copolymer etc.；
The PH regulator is selected from triethanolamine, aminomethyl propanol, arginine, inorganic base etc..
In addition, the present invention has the cosmetic composition of safe antioxidant effect, it is to be made by following processing step:
1) oily mutually material is added in oily phase pot, stirs, is heated to 80 DEG C, dissolution is complete；
2) water phase material is added in water phase pot, stirs, is heated to 80 DEG C, dissolution is complete；
3) water phase pot is first pumped into emulsion pot, then is pumped into oily phase pot material, stir 50rpm 10 minutes, homogeneous 3000rpm
Stabilizer is added in emulsion pot and continues emulsification 3-5 minutes by emulsification 6-8 minutes, adjusts PH, keeps the temperature 15 minutes, cooling；
4) 37 DEG C are cooled to, remaining skin conditioning agent, preservative, aromatic is added, stirs 40rpm 15 minutes, takes
Sample discharges after detection is qualified.
Preferably, the composition can be used for various State of cosmetics, including but not limited to surfactant, facial treatment essence, shield
Skin mile, facial treatment milk, skin care cream, color make-up, face cleaning.
Primary raw material source of the invention and effect are described as follows:
1. small molecule hydrolyzes Sodium Hyaluronate
Small molecule hydrolysis Sodium Hyaluronate, molecular weight≤5000Da, average molecular weight 3000Da or so, purity >=95%,
The small molecule of 0.1% concentration hydrolyzes Sodium Hyaluronate cell proliferation activity up to 95%, safe and non-toxic, and 0.1% small molecule
66.7% can be reduced for average fluorescent strength by hydrolyzing Sodium Hyaluronate, and the free radical scavenging activity based on UVA-L929 model reaches
81%, water-soluble active object has good anti-oxidation protection effect.
2. Delta-Tocopherol
Delta-Tocopherol is to separate, be concentrated from soybean oil, purifying obtained high-content product, and the fat-soluble of efficiency natural resists
Oxidation protection agent is that most stable and oxidation resistance is strongest in tetra- kinds of α, β, γ, δ.Its thermal stability is 10 times high compared with α type
More than, 3 times high compared with γ type or more, there is good photoprotection to a variety of greases, have well to some active constituents, color
Anti-oxidation protection effect.
3. close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extraction
Close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extraction is not dead careless and bluish-green when taking away colored
Algae produces to obtain, and is rich in natural glycerin glucoside, and molecular weight is small, the generation in skin in SOD can be stimulated, to enhance cell
Inoxidizability enhances cell viability, is natural cell activator.
Grape 4. (VITIS VINIFERA) fruit cell extract
Grape (VITIS VINIFERA) fruit cell extract is with extracting from grape (VITIS VINIFERA) fruit in itself
Cell, be added cellular energy liquid, produced using plant cell culture technology, be essentially identical to cell tissue liquid.Grape
(VITIS VINIFERA) fruit cell extract can reduce the reduction of physiology peroxidatic reaction of lipid, thus originality physiology rouge in reducing
The free radical that matter peroxidization generates；And induction property peroxidatic reaction of lipid can be made to reduce, to reduce because of ultraviolet light, change
The production of excessive free radicals caused by induction property peroxidatic reaction of lipid caused by product poisoning, air endotoxin contamination, strong inflammation
It is raw.
Compared with prior art, the present invention have it is following a little and the utility model has the advantages that
Small molecule hydrolysis Sodium Hyaluronate in the present composition is in protection water-soluble active object space face antioxidation
It is prominent；Delta-Tocopherol is prominent in protection liposoluble active object space face antioxidation；Close Luo Mu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extraction is acted in endogenous anti-oxidation protection and being protruded；Grape (VITIS VINIFERA) fruit is thin
Born of the same parents' extract has significant anti-oxidation protection to act in cell tissue liquid layer face；Four kinds of substances complement each other, so that of the present inventionization
The oxidation resistance of cosmetic compositions is significantly improved.
Specific embodiment
The invention discloses a kind of cosmetic compositions with safe antioxidant effect.By weight percentage, the change
The raw material components that cosmetic compositions include have: small molecule hydrolyzes Sodium Hyaluronate 0.02-1.0%, Delta-Tocopherol 0.02-1.0%,
Close Luo Muye/stem extraction 0.1-3.0%, grape fruit cell extract 0.1-2.5%, cosmetic matrix 92.5-
99.76%.
Antioxidant composition of the present invention is mentioned by small molecule hydrolysis Sodium Hyaluronate, Delta-Tocopherol, grape fruit cell
Object, Mi Luomu leaf/four kinds of stem extraction material composition are taken, four kinds of substances complement each other, especially appropriate grape fruit cell extraction
The addition of object can reach skin care item anti-oxidant effect safely to reducing cytotoxicity and improving the effect of composition oxidation resistance obviously
Fruit.
Below by way of specific preferred embodiment combination effete test embodiment, invention is further described in detail, but the present invention
It is not limited in embodiment below.
The cosmetic composition with safe antioxidant effect of 1-6 of the embodiment of the present invention, is prepared into facial treatment milk, former
Expect that component proportion is as shown in table 1 below, and embodiment 1-6 has been subjected to external safety and anti-oxidation efficacy test, stability survey
Examination.
There is the present invention cosmetic composition of safe antioxidant effect to be not listed in the performance of other State of cosmetics.
The facial treatment milk of 1 1-6 of the embodiment of the present invention of table and the component formula (weight percentage %) of reference examples
Above-mentioned 1 emulsifier of table selects cocoyl glucoside；Thickener selects xanthan gum；Preservative selects Phenoxyethanol, benzene
The mixture of sodium formate；Aromatic selects Roman chamomile caul-fat.
Above-described embodiment 1-6 has the preparation method of the cosmetic composition of collaboration antioxidant effect, comprising the following steps:
1) water phase pot is added in A phase raw material, is heated with stirring to 75-80 DEG C, keep the temperature 15 minutes, dissolution is complete；
2) oily phase pot is added in B phase raw material, is heated with stirring to 70-75 DEG C, keep the temperature 5 minutes, melted complete；
3) emulsion pot preheats, and water phase pot material vacuum is pumped into emulsion pot, then opens the lower vacuum of stirring and is pumped into oily phase pot material,
It matter 5 minutes, adds C phase and expects, homogeneous 5 minutes, insulated and stirred 15 minutes, cooling；
4) 40 DEG C are cooled to, D phase is added and expects, stirs evenly；
5) feeding detects, and discharges after qualified.
The following are the contents of effete test embodiment part.
Primary election antioxidant composition concentration of component is concentrated first, is tested with mtt assay, passes through 2,4,6,8,10 etc.
Multiple dilution carries out cell-proliferation activity test, and when cell-proliferation activity reaches close to 80%, then confirmation is to cytotoxic, i.e.,
It may establish that the safe concentration of the antioxidant composition component.
Then Oxidation Resistance Test-use is carried out on the basis of the antioxidant composition component of safety represent oxidation resistance
Classics test: ROS measurement, the elimination factor of DPPH free radical, lipid peroxide (LPO) assay, three test to comment
The oxidation resistance of the valence antioxidant composition component, specific as follows:
Cell-proliferation activity test is carried out by mtt assay first, antioxidant composition concentration is screened:
Mass percent component is concentrated in primary election antioxidant composition:
Mass percent component is concentrated in A antioxidant composition:
Small molecule hydrolyzes Sodium Hyaluronate 1.0%, Delta-Tocopherol 1.0%, Mi Luomu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extraction 30.0%, cosmetic matrix 68%.
Mass percent component is concentrated in B antioxidant composition:
Small molecule hydrolyzes Sodium Hyaluronate 1.0%, Delta-Tocopherol 1.0%, Mi Luomu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extraction 30.0%, grape (VITIS VINIFERA) fruit cell extract 5.0%, cosmetics
Excipient matrix 63%.
Mass percent component is concentrated in C antioxidant composition:
Micromolecule hyaluronic acid sodium 1.0%, Delta-Tocopherol 1.0%, Mi Luomu (MYROTHAMNUS FLABELLIFOLIA)
Leaf/stem extraction 30.0%, grape (VITIS VINIFERA) fruit cell extract 15.0%, cosmetic matrix 53%.
Using mtt assay carry out cell-proliferation activity test, through UVB irradiation HaCaT cell for 24 hours after, measured using mtt assay
Cell Proliferation vigor, modeling group is through 40J/cm2UVB irradiates modeling；Test the diluted concentration versus cell proliferation of antioxidant composition
Activity reaches close to 80%, that is, thinks that this component is that do not have cytotoxic, be safe: to A, B, C in combination object respectively into
2,4,6,8,10 equimultiple of row gradually dilutes, its corresponding cell-proliferation activity is measured when being diluted to 10 times.
Conclusion: by mtt assay cell proliferation activity experiment and oxidation resistance test result, can define, and have safety
Antioxidant effect composition is B antioxidant composition,
Key point is:
Comprehensive Correlation security test result is as shown in the following table 2 and anti-oxidant test result table 3, table 4, table 5.
Antioxidant composition component A:
Small molecule hydrolyzes Sodium Hyaluronate 0.1%, Delta-Tocopherol 0.1%, Mi Luomu (MYROTHAMNUS
FLABELLIFOLIA) 3.0% 3 kind of active matter of leaf/stem extraction has had higher inhibition ROS ability, to DPPH freedom
Clearance rate that base has, the anti-oxidation protection ability for reducing raised LPO content after modeling.
In the case that antioxidant composition B increases grape (VITIS VINIFERA) fruit cell extract 0.5%, reduce
The cytotoxicity of component, improves the safety of component, and significantly improves anti-oxidation efficacy.
But antioxidant composition C resists in the case where grape (VITIS VINIFERA) fruit cell extract 1.5%
Oxidation effectiveness is to reduce, and cytotoxicity increases, so the addition of grape (VITIS VINIFERA) fruit cell extract
Amount is not being not that additive amount is bigger better with regard to effect.
Select concentration of the cell chemokine close to 80% as safe concentration, for the ease of carrying out close under same concentrations
Subsequent inoxidizability test, while data have comparativity, the concentration that anti-oxidant combination selection dilutes 10 times carries out anti-oxidant test,
Determine that antioxidant composition carries out the component of anti-oxidant test:
A antioxidant composition mass percent component: micromolecule hyaluronic acid sodium 0.1%, Delta-Tocopherol 0.1%, close sieve
Wooden (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extraction 3.0%, cosmetic matrix 96.8%.
B antioxidant composition mass percent component: micromolecule hyaluronic acid sodium 0.1%, Delta-Tocopherol 0.1%, close sieve
Wooden (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extraction 3.0%, grape (VITIS VINIFERA) fruit cell extraction
Object 0.5%, cosmetic matrix 96.3%.
C antioxidant composition mass percent component: micromolecule hyaluronic acid sodium 0.1%, Delta-Tocopherol 0.1%, close sieve
Wooden (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extraction 3.0%, grape (VITIS VINIFERA) fruit cell extraction
Object 1.5%, cosmetic matrix 95.3%.
Effete test embodiment 1
Safety and antioxidant effect experiment:
This experiment evaluates safety in mtt assay test cell proliferation activity by detecting anti-oxidant combination, and inhibits ROS energy
Power, the clearance rate having to DPPH free radical, modeling lipid peroxide (LPO) assay evaluate antioxidant effect.
Here, being only illustrated to this experimental result:
Mtt assay test cell proliferation activity sequence: 3 > embodiment of embodiment 5 > embodiment, 4 > embodiment, 2 > embodiment 6
1 > reference examples of > embodiment；
Inhibit ROS ability sequence: 2 > embodiment of embodiment 5 > embodiment, 4 > embodiment, 3 > embodiment, 6 > embodiment 1
> reference examples；
The clearance rate sequence having to DPPH free radical: 3 > embodiment of embodiment 5 > embodiment, 4 > embodiment, 2 > is implemented
6 > embodiment of example, 1 > reference examples；
The assay of lipid peroxide (LPO) sorts: 3 < embodiment of embodiment 5 < embodiment, 4 < embodiment, 2 <
6 < embodiment of embodiment, 1 < reference examples；
Illustrated by result above, the adding proportion that the present invention combines has preferably range, has within this range very well
Safe antioxidant effect, be not that the additive amount the high better.
Effete test embodiment 2
Stability test:
1) stability test sample: embodiment 5, reference examples product.
2) test method: inner quality standard (high temperature, low temperature, high/low temperature recycle 1 month, illumination 1 month) is higher than professional standard
And national standard.
3) test result is shown, embodiment 5 has good stability, the illumination of reference examples and high temperature, high/low temperature circulation
It is all unstable, it may appear that change colour more serious situation.
Effete test embodiment 3
Security test:
It is tested with mtt assay, test cell proliferation activity.
The anti-oxidant combination A-C of table 2, with positive group, the security test of control group
As can be seen from Table 2, compared with blank control group, through 40J/cm2After UVB irradiates modeling, absorbance of cells and deposit
Motility rate significantly reduces, and is down to 50.64%；Compared with model group, anti-oxidant combination A, B, C can obviously restore the cell after modeling
Proliferation activity, light absorption value are respectively 0.523,0.731,0.569, and survival rate is respectively 53.45%, 74.72%, 58.21%.
Effete test embodiment 3
The test of 3.1 oxidation resistances:
Establish safe antioxidant composition component in the case where, the representative oxidation resistance that chooses a trade generally acknowledged is surveyed
Three typical index of examination are tested:
ROS measurement, the elimination factor of DPPH free radical, lipid peroxide (LPO) assay, test method according to
According to A, B, C in combination progress antioxygenic property test:
ROS measurement, active oxygen (reactive oxy gen species, ROS) are the one-electron reductions of internal a kind of oxygen
Product, including superoxide anion (O2), hydrogen peroxide (H2O2), hydroxyl radical free radical (OH) and nitric oxide etc., therefore select
Sample Scavenging ability is selected as one of oxidation resistance evaluation method, wherein using the vitamin C of 100 μ g/ml as sun
Property control, as shown in table 3 below.
The anti-oxidant combination A-C of table 3 is tested with the oxidation resistance of positive control, negative control
As can be seen from Table 3, after test sample dilutes 10 times, the result of free radical ROS is showed.Wherein anti-oxidant group
After closing 10 times of B, anti-oxidant combination C dilution, ROS ability is inhibited to be better than positive control, anti-oxidant combination B function and effect are higher than other
The ability of test sample, anti-oxidant combination A is weaker than positive control；Anti-oxidant combination B is to inhibit ROS ability most strong in 3 samples,
Anti-oxidant combination C takes second place, and anti-oxidant combination A is most weak.
The measurement of 3.2DPPH free radical scavenging activity:
Inspection method is put using the biochemistry of food service industry comparative maturity and surveys DPPH free radical elimination factor, Vc (1mg/mL) is positive right
According to group:
The anti-oxidant combination A-C of table 4 is tested with the oxidation resistance of positive control
As can be seen from Table 4, showing DPPH free radical scavenging activity result after test sample dilutes 10 times.It is wherein anti-oxidant
B is combined, clearance rate is higher than positive control, and function and effect are higher than other test samples, and anti-oxidant combination A and anti-oxidant combination C make
With positive control is weaker than, anti-oxidant combination A is most weak.
The assay of 3.3 lipid peroxide (LPO):
The assay of lipid peroxide (LPO) is to act on the HaCaT irradiated through UVB with anti-oxidant combination A, B, C
Cell for 24 hours after, intracellular LPO content is measured using ELISA method, model group is through 40J/cm2UVB irradiates modeling:
The anti-oxidant combination A-C of table 5 is tested with the oxidation resistance of positive control, control group
As can be seen from Table 5, compared with blank control group, through 40J/cm2After UVB irradiates modeling, the LPO of HaCaT cell
Content is increased to 11.10 ± 0.84 μm of ol/L (P < 0.001)；Compared with model group, anti-oxidant combination A, B, C, which can significantly reduce, to be made
Raised LPO content after mould, content be down to respectively 9.18 ± 0.52 μm of ol/L (P < 0.01), 6.75 ± 0.47 μm of ol/L (P <
0.001)、8.48±0.49μmol/L(P<0.01)。
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
Without departing from the technical solutions of the present invention, to the above embodiments according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (10)
1. a kind of cosmetic composition with safe antioxidant effect, which is characterized in that the composition includes following matter
Measure percent composition:
Small molecule hydrolyzes Sodium Hyaluronate 0.02-1.0%；Delta-Tocopherol 0.02-1.0%；Close Luo Mu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extraction 0.1-3.0%；Grape (VITIS VINIFERA) fruit cell extract 0.1-2.5%；
Cosmetic matrix 92.5-99.76%.
2. as described in claim 1 with the cosmetic composition of safe antioxidant effect, it is characterised in that: include following matter
Measure the component of percentage:
Small molecule hydrolyzes Sodium Hyaluronate 0.03-0.1%；Delta-Tocopherol 0.1%；Close Luo Mu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extraction 0.5-3.0%；Grape (VITIS VINIFERA) fruit cell extract 0.2-0.5%；
Cosmetic matrix 96.3-99.17%.
3. as claimed in claim 2 with the cosmetic composition of safe antioxidant effect, it is characterised in that: include following matter
Measure the component of percentage:
Micromolecule hyaluronic acid sodium 0.1%；Delta-Tocopherol 0.1%；Close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf/
Stem extraction 3.0%；Grape (VITIS VINIFERA) fruit cell extract 0.5%；Cosmetic matrix 96.3%.
4. as claimed in claim 1 or 2 with the cosmetic composition of safe antioxidant effect, it is characterised in that: described small
The molecular weight that molecule hydrolyzes Sodium Hyaluronate is≤10000Da.
5. as claimed in claim 4 with the cosmetic composition of safe antioxidant effect, it is characterised in that: the small molecule
Hydrolyze the molecular weight Wei≤5000Da, about 3000Da or so of Sodium Hyaluronate.
6. as described in claim 1 with the cosmetic composition of safe antioxidant effect, it is characterised in that: the cosmetics
Excipient matrix include solvent, moisturizer, chelating agent, emollient, skin conditioning agent, emulsifier, aromatic, preservative, thickener,
One of PH regulator is a variety of.
7. the cosmetic composition with collaboration antioxidant effect as claimed in claim 6, it is characterised in that: percentage by weight
Than meter, the cosmetic matrix is made of raw material components below:
8. as claimed in claim 6 with the cosmetic composition of safe antioxidant effect, it is characterised in that:
The solvent is selected from one of water, propylene glycol, methyl propanediol, dipropylene glycol, pentanediol, isoprene or a variety of；
The moisturizer is selected from one of glycerol, polyglyceryl ether -26, butanediol, polyglycereol -6,1,3-PD or a variety of；
The chelating agent is selected from one of EDTA-2Na, EDTA-3Na, decoyl hydroximic acid or a variety of；
The skin conditioning agent be selected from plant extracts, plant callus extract, tunning, small molecule vegetable protein and
One of peptides are a variety of；
The emollient is selected from silicone oil and Synthetic Oil, vegetable fat etc.；
It is non-that the emulsifier is selected from glycoside, sucrose ester, amino acids, glyceride type and polyglycereol esters, polyethylene glycols
One of ion is a variety of；
The aromatic is selected from natural extraction plants essential oil, the synthesis fragrance of a flower, synthesis fruity or compound flower fruity etc.；
The preservative is selected from Phenoxyethanol, parabens, benzoic acid and its esters, dehydroactic acid and its esters, diacetic acid
Sodium etc.；
It is total that the thickener is selected from xanthan gum, carragheen, carbomer, high molecular cellulose, Sodium Polyacrylate, acrylic acid (ester) class
Polymers etc.；
The PH regulator is selected from triethanolamine, aminomethyl propanol, arginine, inorganic base etc..
9. as claimed in claim 7 with the cosmetic composition of safe antioxidant effect, which is characterized in that be by following work
Skill step is made:
1) oily mutually material is added in oily phase pot, stirs, is heated to 80 DEG C, dissolution is complete；
2) water phase material is added in water phase pot, stirs, is heated to 80 DEG C, dissolution is complete；
3) water phase pot is first pumped into emulsion pot, then is pumped into oily phase pot material, stir 50rpm 10 minutes, homogeneous 3000rpm emulsification
6-8 minutes, stabilizer is added in emulsion pot and continues emulsification 3-5 minutes, adjust PH, keeps the temperature 15 minutes, cooling；
4) 37 DEG C are cooled to, remaining skin conditioning agent, preservative, aromatic is added, is stirred 40rpm 15 minutes, is sampled, inspection
It discharges after surveying qualification.
10. the cosmetic composition as claimed in claim 6 with safe antioxidant effect, it is characterised in that: the composition
Can be made into surfactant, facial treatment essence, skin care mile, facial treatment milk, skin care cream, color make-up, face cleaning cream.
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| CN111329810A (en) * | 2020-04-10 | 2020-06-26 | 上海新高姿化妆品有限公司 | Antioxidant anti-aging cosmetic composition |
| CN112402310A (en) * | 2020-10-30 | 2021-02-26 | 广州市妆妍生物技术有限公司 | Vitreous chromogen polypeptide anti-wrinkle eye cream and preparation method thereof |
| WO2023137140A1 (en) * | 2022-01-14 | 2023-07-20 | Dow Global Technologies Llc | Glycol compositions including tocopherols |
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| CN108379140A (en) * | 2018-03-12 | 2018-08-10 | 珠海吉祥健康产业有限公司 | A kind of composition and preparation method thereof with whitening anti-aging function |
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| CN111329810A (en) * | 2020-04-10 | 2020-06-26 | 上海新高姿化妆品有限公司 | Antioxidant anti-aging cosmetic composition |
| CN111329810B (en) * | 2020-04-10 | 2022-10-18 | 上海新高姿化妆品有限公司 | Antioxidant anti-aging cosmetic composition |
| CN112402310A (en) * | 2020-10-30 | 2021-02-26 | 广州市妆妍生物技术有限公司 | Vitreous chromogen polypeptide anti-wrinkle eye cream and preparation method thereof |
| WO2023137140A1 (en) * | 2022-01-14 | 2023-07-20 | Dow Global Technologies Llc | Glycol compositions including tocopherols |
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