CN110464672B - Cosmetic composition with safe antioxidant effect - Google Patents
Cosmetic composition with safe antioxidant effect Download PDFInfo
- Publication number
- CN110464672B CN110464672B CN201910846557.XA CN201910846557A CN110464672B CN 110464672 B CN110464672 B CN 110464672B CN 201910846557 A CN201910846557 A CN 201910846557A CN 110464672 B CN110464672 B CN 110464672B
- Authority
- CN
- China
- Prior art keywords
- antioxidant
- cosmetic
- cosmetic composition
- antioxidant effect
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention discloses a cosmetic composition with safe antioxidant effect. The cosmetic composition comprises the following raw material components in percentage by weight: 0.02-1.0% of micromolecular hydrolyzed sodium hyaluronate, 0.02-1.0% of delta-tocopherol, 0.1-3.0% of millettia speciosa leaf/stem extract, 0.1-2.5% of grape fruit cell extract and 92.5-99.76% of cosmetic auxiliary material matrix. The antioxidant composition disclosed by the invention is composed of micromolecular hydrolyzed sodium hyaluronate, delta-tocopherol, grape fruit cell extract and millettia speciosa leaf/stem extract, the four substances supplement each other, particularly, the addition of a proper amount of grape fruit cell extract has obvious effects of reducing cytotoxicity and improving the antioxidant capacity of the composition, and the safe antioxidant effect of a skin care product can be achieved.
Description
Technical Field
The invention relates to a skin care product, belongs to the technical field of cosmetic production, and particularly relates to a cosmetic composition with a safe antioxidant effect and a preparation method thereof.
Background
With the urban development, air pollution, PM2.5 and the aggravation of sunlight ultraviolet irradiation, a large number of free radicals such as nitrogen, sulfur, oxygen and the like are easily generated on human skin due to exposure, so that the structures of cells, proteins and the like are damaged, and the repairing is impossible. Therefore, the immune function of the human body is reduced, the skin of the human body is also dim, loose, sensitive, wrinkled and the like, and the skin is more and more resistant to oxidation.
At present, the antioxidant cosmetics have a plurality of facial features:
1) many use a single reducing substance, but the specific oxidation resistance is almost no longer true, and no actual test or less than complete;
2) some of the reducing substances are used, but the synergistic effect is not achieved, and only simple combination is achieved, or the synergistic effect is not proved to be sufficient;
3) the antioxidant cosmetics have the problems of stability and discoloration;
4) the more the antioxidant is used in the antioxidant cosmetic, the better the antioxidant is, and the more the antioxidant is used in the antioxidant cosmetic, the more the antioxidant is used in some substances, the negative effect can be realized;
5) many antioxidant cosmetics do not take into account the presence of water and lipids in the skin environment, and the choice of antioxidant also requires consideration of the balance of oil-water phase partitioning.
At present, the raw material components on the market are not comprehensive enough in action or low in safety; there is a need, then, to develop an antioxidant composition that is truly safe.
Disclosure of Invention
In order to overcome the defects and shortcomings of the existing antioxidant cosmetics, the invention aims to provide a skin-care cosmetic which can safely protect skin; also has antioxidant effect.
The cosmetic composition with safe antioxidant effect provided by the invention is realized by the following technical scheme.
A cosmetic composition with safe antioxidant effect comprises the following components in percentage by mass:
0.02-1.0% of micromolecular hydrolyzed sodium hyaluronate; 0.02-1.0% of delta-tocopherol; extract of leaves/stems of Michelia Ardisia (Myrothamnus FLABELLIFOLIA) 0.1-3.0%; grape (VITIS VINIFERA) fruit cell extract 0.1-2.5%; 92.5-99.76% of cosmetic auxiliary material matrix.
On the basis of combining the best sample of the cosmetic composition experiment with the safe antioxidant effect, namely the safe antioxidant effect cosmetic composition B, combining cost factors and the specificity of the functions of all components, and considering that the cosmetic composition still has the antioxidant effect under the safe concentration of the components of the composition, the optimal selection is established, and the cosmetic composition with the safe antioxidant effect comprises the following raw material components in percentage by mass:
further, the cosmetic composition with the safe antioxidant effect comprises the following raw material components in percentage by mass:
furthermore, the molecular weight of the small-molecule hydrolyzed sodium hyaluronate is less than or equal to 10000 Da.
Preferably, the molecular weight of the small-molecule hydrolyzed sodium hyaluronate is less than or equal to 5000Da and about 3000 Da.
Preferably, the cosmetic adjunct base comprises one or more of a solvent, a humectant, a chelating agent, an emollient, a skin conditioning agent, an emulsifier, a solubilizer, a fragrance, a preservative, a thickener, a PH adjuster.
Preferably, the solvent is selected from one or more of water, propylene glycol, methyl propylene glycol, dipropylene glycol, pentanediol and isoprene glycol;
the humectant is selected from one or more of glycerol, polyglycerol ether-26, butanediol, polyglycerol-6 and 1, 3-propylene glycol;
the chelating agent is selected from one or more of EDTA-2Na, EDTA-3Na and caprylyl hydroximic acid;
the skin conditioner is selected from one or more of plant extract, plant callus extract, fermentation product, small molecule plant protein and peptide;
the emollient is selected from silicone oil, synthetic oil, vegetable oil, etc
The emulsifier is selected from one or more of glycosides, sucrose esters, amino acids, glycerides and polyglycerol esters, and polyethylene glycol nonionic;
the aromatic is selected from natural extracted plant essential oil, synthetic flower fragrance, synthetic fruit fragrance or composite flower and fruit fragrance;
the preservative is selected from phenoxyethanol, parabens, benzoic acid and salts thereof, dehydroacetic acid and salts thereof, sodium diacetate and the like;
the thickening agent is selected from xanthan gum, carrageenan, carbomer, high molecular cellulose, sodium polyacrylate, acrylic acid (ester) copolymer and the like;
the pH regulator is selected from triethanolamine, aminomethyl propanol, arginine, inorganic alkali, etc.
In addition, the cosmetic composition with safe antioxidant effect is prepared by the following process steps:
1) adding the oil phase material into an oil phase pot, stirring, heating to 80 deg.C, and dissolving completely;
2) adding the water phase material into a water phase pot, stirring, heating to 80 ℃, and completely dissolving;
3) pumping the water phase pot into an emulsifying pot, pumping the oil phase pot material into the emulsifying pot, stirring at 50rpm for 10 minutes, homogenizing at 3000rpm for 6-8 minutes, adding the stabilizer into the emulsifying pot, continuously emulsifying for 3-5 minutes, adjusting the pH, keeping the temperature for 15 minutes, and cooling;
4) cooling to 37 ℃, adding the rest of the skin conditioner, the preservative and the aromatic, stirring for 15 minutes at 40rpm, sampling, and discharging after the detection is qualified.
Preferably, the composition can be used in various cosmetic formulations including, but not limited to, skin lotions, skin essences, skin gels, skin lotions, skin creams, color cosmetics, cleansing.
The main raw material sources and the effects of the invention are illustrated as follows:
firstly, micromolecule hydrolyzed sodium hyaluronate
The micromolecular hydrolyzed sodium hyaluronate has the molecular weight of less than or equal to 5000Da, the average molecular weight of about 3000Da, the purity of more than or equal to 95 percent, the cell proliferation activity of 0.1 percent of micromolecular hydrolyzed sodium hyaluronate reaches 95 percent, the micromolecular hydrolyzed sodium hyaluronate is safe and non-toxic, the average fluorescence intensity of 0.1 percent of micromolecular hydrolyzed sodium hyaluronate can be reduced by 66.7 percent, the free radical clearance rate based on a UVA-L929 model reaches 81 percent, and the water-soluble active substance has good antioxidant protection effect.
② delta-tocopherol
The delta-tocopherol is a high-content product obtained by separating, concentrating and purifying soybean oil, is a natural and efficient fat-soluble antioxidant protective agent, and is the most stable and strongest antioxidant in four types of alpha, beta, gamma and delta. The thermal stability of the oil is more than 10 times higher than that of the alpha type and more than 3 times higher than that of the gamma type, and the oil has good photoprotection effect on various oils and has good antioxidant protection effect on some active ingredients and colors.
Extract of leaves/stems of Michloa FLABELLIFOLIA
Extract of leaves/stems of Artocarpus heterophyllus (Myrothamnus FLABELLIFOLIA) is prepared from Lawsonia inermis and blue-green algae during blooming, is rich in natural glycerol glucoside, has small molecular weight, and can stimulate production of SOD in skin, thereby enhancing oxidation resistance and cell activity of cells, and is natural cell activator.
(VITIS VINIFERA) grape fruit cell extract
The grape (VITIS VINIFERA) fruit cell extract is prepared by adding cell energy solution into cell extracted from grape (VITIS VINIFERA) fruit, and culturing with plant cell culture technology, and is substantially equivalent to cell tissue solution. The grape (VITIS VINIFERA) fruit cell extract can reduce physiological lipid peroxidation, thereby reducing free radicals generated by endogenous physiological lipid peroxidation; and reducing induced lipid peroxidation, thereby reducing excessive free radical generation caused by induced lipid peroxidation due to ultraviolet, chemical poisoning, air toxin pollution, and strong inflammation.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the micromolecular hydrolyzed sodium hyaluronate in the composition has an obvious antioxidation effect on the aspect of protecting water-soluble active substances; the delta-tocopherol has outstanding antioxidation in the aspect of protecting fat-soluble active substances; the extract of leaves/stems of Michelia Ardisia (Myrothamnus FLABELLIFOLIA) has outstanding effect in protecting endogenous oxidation resistance; the grape (VITIS VINIFERA) fruit cell extract has obvious antioxidant protection effect on the level of cell tissue fluid; the four substances supplement each other, so that the antioxidant capacity of the cosmetic composition is remarkably improved.
Detailed Description
The invention discloses a cosmetic composition with safe antioxidant effect. The cosmetic composition comprises the following raw material components in percentage by weight: 0.02-1.0% of micromolecular hydrolyzed sodium hyaluronate, 0.02-1.0% of delta-tocopherol, 0.1-3.0% of millettia speciosa leaf/stem extract, 0.1-2.5% of grape fruit cell extract and 92.5-99.76% of cosmetic auxiliary material matrix.
The antioxidant composition disclosed by the invention comprises micromolecular hydrolyzed sodium hyaluronate, delta-tocopherol, grape fruit cell extract and millettia speciosa leaf/stem extract, wherein the four substances supplement each other, and particularly, the addition of a proper amount of grape fruit cell extract has obvious effects of reducing cytotoxicity and improving the antioxidant capacity of the composition, so that the safe antioxidant effect of a skin care product can be achieved.
The present invention will be described in more detail below with reference to specific preferred embodiments and examples of effects, but the present invention is not limited to the following examples.
The cosmetic compositions with safe antioxidant effect of examples 1-6 of the present invention were prepared into skin care emulsions, the raw material components thereof are shown in table 1 below, and the in vitro safety and antioxidant efficacy tests and stability tests of examples 1-6 were performed.
The performance of the cosmetic composition with safe antioxidant effect in other cosmetic formulations is not shown.
TABLE 1 skin care lotions of examples 1-6 of the present invention and the comparative example have the following composition formula (wt%)
The emulsifier in Table 1 above is coco glucoside; the thickening agent is xanthan gum; the preservative is selected from the mixture of phenoxyethanol and sodium benzoate; the aromatic agent is flos Chrysanthemi Indici oil.
The preparation method of the cosmetic composition having the synergistic antioxidant effect of the above examples 1 to 6 comprises the steps of:
1) adding the phase A raw material into a water phase pot, stirring and heating to 75-80 ℃, preserving heat for 15 minutes, and completely dissolving;
2) adding the phase B raw material into an oil phase pot, stirring and heating to 70-75 ℃, preserving heat for 5 minutes, and completely melting;
3) preheating an emulsifying pot, pumping the water phase pot material into the emulsifying pot in vacuum, pumping the water phase pot material into the oil phase pot material in vacuum with stirring, homogenizing for 5 minutes, adding the C phase material, homogenizing for 5 minutes, keeping the temperature, stirring for 15 minutes, and cooling;
4) cooling to 40 ℃, adding the phase D material, and uniformly stirring;
5) and (5) taking materials, detecting, and discharging after the materials are qualified.
The following are contents of the effect test examples.
Firstly, concentrating the concentration of the components of the primarily selected antioxidant composition, applying an MTT method experiment, carrying out cell proliferation activity test by dilution with equal times of 2, 4, 6, 8 and 10, and confirming that the antioxidant composition has no toxicity to cells when the cell proliferation activity reaches nearly 80 percent, namely, the safe concentration of the components of the antioxidant composition can be established.
Then an antioxidant test is performed on the basis of safe antioxidant composition components-using a classical test representing antioxidant capacity: ROS measurement, DPPH free radical elimination rate and Lipid Peroxide (LPO) content measurement, and three tests are used for evaluating the antioxidant capacity of the components of the antioxidant composition, and specifically the following are carried out:
the cell proliferation activity test was first performed by the MTT method, screening the antioxidant composition concentration:
the concentrated antioxidant composition comprises the following components in percentage by mass:
the antioxidant composition A comprises the following concentrated components in percentage by mass:
small molecule hydrolyzed sodium hyaluronate 1.0%, delta-tocopherol 1.0%, Artocarpus heterophyllus (Myrothamnus FLABELLIFOLIA) leaf/stem extract 30.0%, and cosmetic adjuvant matrix 68%.
The antioxidant composition B comprises the following concentrated components in percentage by mass:
1.0% of small molecule hydrolyzed sodium hyaluronate, 1.0% of delta-tocopherol, 30.0% of extract of leaves/stems of MYROTHAMNUS FLABELLIFOLIA, 5.0% of extract of grape (VITIS VINIFERA) fruit cells and 63% of cosmetic auxiliary material matrix.
C, concentrated components of the antioxidant composition in percentage by mass:
1.0% of small molecule sodium hyaluronate, 1.0% of delta-tocopherol, 30.0% of extract of leaves/stems of MYROTHAMNUS FLABELLIFOLIA, 15.0% of extract of grape (VITIS VINIFERA) fruit cells and 53% of cosmetic adjuvant matrix.
Testing cell proliferation activity by MTT method, measuring cell proliferation activity by MTT method after UVB irradiated HaCaT cell for 24h, and modeling by 40J/cm2Carrying out UVB irradiation molding; the concentration of the diluted antioxidant composition tested reached approximately 80% activity on cell proliferation, i.e. this component was considered non-cytotoxic and safe: a, B, C compositions were diluted stepwise in equal multiples of 2, 4, 6, 8, 10, respectively, and their corresponding cell proliferation activities were measured when diluted 10-fold.
And (4) conclusion: through MTT method cell proliferation activity experiment and antioxidant capacity test results, the composition with safe antioxidant effect is B antioxidant composition,
the key points are as follows:
the comprehensive comparative safety test results are shown in table 2 below and the antioxidant test results in tables 3, 4 and 5.
The antioxidant composition comprises a component A:
the three active substances of 0.1 percent of micromolecule hydrolyzed sodium hyaluronate, 0.1 percent of delta-tocopherol and 3.0 percent of extract of leaves/stems of MYROTHAMNUS FLABELLIFOLIA (MYROTHAMNUS FLABELLIFOLIA) have higher ROS inhibiting capability, scavenging rate on DPPH & free radicals and antioxidant protection capability of reducing the increased LPO content after molding.
The antioxidant composition B reduces cytotoxicity of the components, improves safety of the components and remarkably improves antioxidant effect under the condition that 0.5 percent of grape (VITIS VINIFERA) fruit cell extract is added.
However, in the case of 1.5% of grape (VITIS VINIFERA) fruit cell extract, the antioxidant effect is reduced and the cytotoxicity is increased, so that the effect is better when the addition amount of grape (VITIS VINIFERA) fruit cell extract is not increased.
The concentration with the cell proliferation activity close to 80% is selected as a safe concentration, in order to facilitate the subsequent oxidation resistance test under the condition of the similar concentration, and simultaneously, the data is comparable, and the concentration diluted by 10 times is selected for the oxidation resistance test of the oxidation resistance combination, namely, the components of the oxidation resistance composition for the oxidation resistance test are determined:
the antioxidant composition A comprises the following components in percentage by mass: 0.1% of small molecule sodium hyaluronate, 0.1% of delta-tocopherol, 3.0% of extract of leaves/stems of MYROTHAMNUS FLABELLIFOLIA, and 96.8% of cosmetic adjuvant matrix.
The antioxidant composition comprises the following components in percentage by mass: 0.1% of small molecule sodium hyaluronate, 0.1% of delta-tocopherol, 3.0% of extract of leaves/stems of MYROTHAMNUS FLABELLIFOLIA, 0.5% of extract of grape (VITIS VINIFERA) fruit cells and 96.3% of cosmetic adjuvant matrix.
The antioxidant composition comprises the following components in percentage by mass: 0.1% of small molecule sodium hyaluronate, 0.1% of delta-tocopherol, 3.0% of extract of leaves/stems of MYROTHAMNUS FLABELLIFOLIA, 1.5% of extract of grape (VITIS VINIFERA) fruit cells and 95.3% of cosmetic adjuvant matrix.
Effect test example 1
Safety and antioxidant effect experiment:
in the experiment, the cell proliferation activity is tested by detecting the antioxidant combination in an MTT method to evaluate the safety, the ROS inhibiting capacity, the DPPH-free radical clearance rate and the content measurement of modeling Lipid Peroxide (LPO) to evaluate the antioxidant effect.
Only the results of this experiment will be explained here:
sequencing of cell proliferation activity by MTT method: example 5 > example 4 > example 3 > example 2 > example 6 > example 1 > control;
ranking for ROS inhibition: example 5 > example 4 > example 3 > example 2 > example 6 > example 1 > control;
ranking of DPPH. clearance of free radicals: example 5 > example 4 > example 3 > example 2 > example 6 > example 1 > control;
content determination order of Lipid Peroxides (LPO): example 5 < example 4 < example 3 < example 2 < example 6 < example 1 < control;
the above results show that the combination of the present invention has a preferable range of addition ratio, and has a good safe antioxidant effect in this range, not the higher the addition amount is, the better the effect is.
Effect test example 2
And (3) stability testing:
1) stability test samples: example 5, comparative product.
2) The test method comprises the following steps: the internal control standard (high temperature, low temperature, high and low temperature circulation for 1 month, and illumination for 1 month) is higher than the industry standard and the national standard.
3) The test results show that example 5 has good stability, and the control example is unstable in illumination, high temperature and high temperature cycles, and the discoloration is severe.
Effect test example 3
And (3) safety testing:
the cell proliferation activity was tested using MTT assay.
TABLE 2 safety testing of antioxidant combinations A-C, with positive and control groups
As can be seen from Table 2, the ratio of the total weight of the sample was 40J/cm as compared with that of the blank control group2After UVB irradiation molding, the light absorption value and the survival rate of cells are both obviously reduced to 50.64%; compared with a model group, the antioxidant combination A, B, C can obviously recover the cell proliferation activity after the model is made, the light absorption values are 0.523, 0.731 and 0.569 respectively, and the survival rates are 53.45%, 74.72% and 58.21% respectively.
Effect test example 3
3.1 antioxidant capacity test:
with the components of the safe antioxidant composition established, three typical indexes accepted by the industry to represent the antioxidant capacity test were selected for testing:
ROS measurement, DPPH free radical elimination rate, content measurement of Lipid Peroxide (LPO), and the basis of the test method, the A, B, C combination is subjected to an antioxidant performance test:
ROS assay, Reactive Oxygen Species (ROS), a product of the one-electron reduction of a class of oxygen in vivo, including superoxide anions (O)2-) hydrogen peroxide (H)2O2) Hydroxyl radical (. OH), nitric oxide, etc., and thus the ability of the sample to scavenge free radicals was selected as one of the evaluation methods for antioxidant ability, in which vitamin C at 100. mu.g/ml was used as a positive control, as shown in Table 3 below.
TABLE 3 antioxidant combination A-C, antioxidant Capacity test with Positive control, negative control
As can be seen from table 3, the test samples all exhibited the results of free radical ROS after being diluted 10-fold. After the antioxidant combination B and the antioxidant combination C are diluted by 10 times, the ROS inhibiting capacity is higher than that of a positive control, the action effect of the antioxidant combination B is higher than that of other test samples, and the capacity of the antioxidant combination A is weaker than that of the positive control; the antioxidant combination B has the strongest ability of inhibiting ROS in 3 samples, the antioxidant combination C times, and the antioxidant combination A is the weakest.
3.2DPPH radical scavenging assay:
the DPPH free radical elimination rate is detected by adopting a relatively mature biochemical amplification detection method in the food industry, and Vc (1mg/mL) is a positive control group:
TABLE 4 antioxidant combination A-C, antioxidant Capacity test with Positive control
As seen from table 4, the test samples all exhibited DPPH radical scavenging results after 10-fold dilution. The clearance rate of the antioxidant combination B is higher than that of a positive control, the action effect of the antioxidant combination B is higher than that of other test samples, the effects of the antioxidant combination A and the antioxidant combination C are weaker than that of the positive control, and the antioxidant combination A is the weakest.
3.3 content determination of Lipid Peroxides (LPO):
the content of Lipid Peroxide (LPO) is measured by acting antioxidant combination A, B, C on HACaT cells irradiated by UVB for 24h, and measuring the content of LPO in the cells by ELISA method, wherein the model group is measured by 40J/cm2UVB irradiation molding:
TABLE 5 antioxidant combination A-C, antioxidant Capacity test with Positive control, control group
As can be seen from Table 5, the ratio of the total weight of the sample was 40J/cm as compared with that of the blank control group2After UVB irradiation modeling, the LPO content of HaCaT cells is increased to 11.10 +/-0.84 mu mol/L (P)<0.001); compared with a model group, the antioxidant combination A, B, C can obviously reduce the increased LPO content after molding, and the content is respectively reduced to 9.18 +/-0.52 mu mol/L (P)<0.01)、6.75±0.47μmol/L(P<0.001)、8.48±0.49μmol/L(P<0.01)。
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Claims (6)
1. The cosmetic composition with the safe antioxidant effect is characterized by comprising the following components in percentage by mass:
0.1% of micromolecular hydrolyzed sodium hyaluronate; 0.1% of delta-tocopherol; extract of leaves/stems of Artocarpus heterophyllus (Myrothamnus FLABELLIFOLIA) 3.0%; grape (VITIS VINIFERA) fruit cell extract 0.5%; 96.3% of cosmetic auxiliary material matrix; the molecular weight of the micromolecular hydrolyzed sodium hyaluronate is less than or equal to 5000 Da;
the cell extract of grape (VITIS VINIFERA) fruit is prepared by adding cell energy solution into cells extracted from grape (VITIS VINIFERA) fruit, and culturing with plant cell culture technology.
2. The cosmetic composition having safe antioxidant effect as claimed in claim 1, wherein: the delta-tocopherol is a fat-soluble antioxidant protective agent obtained by separating, concentrating and purifying soybean oil.
3. The cosmetic composition having safe antioxidant effect as claimed in claim 2, wherein:
the cosmetic adjuvant matrix comprises one or more of solvent, humectant, chelating agent, emollient, skin conditioner, emulsifier, aromatic, antiseptic, thickener, and pH regulator.
4. The cosmetic composition having safe antioxidant effect as claimed in claim 3, wherein: the cosmetic auxiliary material matrix comprises the following raw material components in percentage by weight:
5. the cosmetic composition having safe antioxidant effect as claimed in claim 4, wherein:
the solvent is selected from one or more of water, propylene glycol, methyl propylene glycol, dipropylene glycol, pentanediol and isoprene glycol;
the humectant is selected from one or more of glycerol, polyglycerol ether-26, butanediol, polyglycerol-6 and 1, 3-propylene glycol;
the chelating agent is selected from one or more of EDTA-2Na, EDTA-3Na and caprylyl hydroximic acid;
the skin conditioner is selected from one or more of plant callus extract, fermentation product, small molecular plant protein and peptide;
the emollient is selected from synthetic oil and vegetable oil;
the emulsifier is selected from one or more of glycosides, sucrose esters, amino acids, glycerides and polyglycerides, and polyethylene glycol;
the aromatic is selected from natural extracted plant essential oil, synthetic flower fragrance, synthetic fruit fragrance or composite flower and fruit fragrance;
the preservative is selected from phenoxyethanol, parabens, benzoic acid and salts thereof, dehydroacetic acid and salts thereof, and sodium diacetate;
the thickening agent is selected from xanthan gum, carrageenan, carbomer, high molecular cellulose, sodium polyacrylate and acrylic acid (ester) copolymer;
the pH regulator is selected from triethanolamine, aminomethyl propanol, arginine and inorganic alkali.
6. The cosmetic composition having safe antioxidant effect as claimed in claim 4, wherein: the composition can be made into skin lotion, skin essence, skin gel, skin lotion, skin cream, and color cosmetic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910846557.XA CN110464672B (en) | 2019-09-09 | 2019-09-09 | Cosmetic composition with safe antioxidant effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910846557.XA CN110464672B (en) | 2019-09-09 | 2019-09-09 | Cosmetic composition with safe antioxidant effect |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110464672A CN110464672A (en) | 2019-11-19 |
| CN110464672B true CN110464672B (en) | 2022-03-22 |
Family
ID=68515274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910846557.XA Active CN110464672B (en) | 2019-09-09 | 2019-09-09 | Cosmetic composition with safe antioxidant effect |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110464672B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329810B (en) * | 2020-04-10 | 2022-10-18 | 上海新高姿化妆品有限公司 | Antioxidant anti-aging cosmetic composition |
| CN112402310A (en) * | 2020-10-30 | 2021-02-26 | 广州市妆妍生物技术有限公司 | Vitreous chromogen polypeptide anti-wrinkle eye cream and preparation method thereof |
| WO2023137140A1 (en) * | 2022-01-14 | 2023-07-20 | Dow Global Technologies Llc | Glycol compositions including tocopherols |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015040230A (en) * | 2013-08-20 | 2015-03-02 | 学校法人東京理科大学 | Antioxidant composition and cosmetic containing the same |
| CN108379140B (en) * | 2018-03-12 | 2021-06-04 | 珠海吉祥健康产业有限公司 | Composition with whitening and anti-aging functions and preparation method thereof |
| CN108635247B (en) * | 2018-06-27 | 2020-05-05 | 广州澳希亚实业有限公司 | Cosmetic composition containing sodium hyaluronate |
| CN109431940A (en) * | 2018-12-24 | 2019-03-08 | 广州仙施生物科技有限公司 | A kind of skin lightening essence cream and preparation method thereof |
| CN110123705B (en) * | 2019-06-24 | 2022-01-07 | 广州澳希亚实业有限公司 | Moisturizing and anti-wrinkle composition and skin care product |
-
2019
- 2019-09-09 CN CN201910846557.XA patent/CN110464672B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110464672A (en) | 2019-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110464672B (en) | Cosmetic composition with safe antioxidant effect | |
| CN106727027B (en) | Blue light resisting, oxidation resisting and free radical scavenging composition, skin care product and preparation method | |
| WO2017146445A1 (en) | Cosmetic composition containing mixed extract of camellia flowers, cherry blossom flowers, jasmine flowers, chamomile flowers, and lotus flowers | |
| CN113081906B (en) | Astaxanthin composition and preparation method and application thereof | |
| CN112618457A (en) | Chloasma-removing composition and preparation method and application thereof | |
| CN110721120A (en) | Multifunctional skin care cream and preparation method thereof | |
| KR101528275B1 (en) | Cosmetic composition with the extract of Solidago virgaurea L. var coreana Nakai, Aster tataricus, Saxifraga stolonifera | |
| KR100984163B1 (en) | Humectant cosmetic composition comprising chayote extract and manufacturing method thereof | |
| KR100361551B1 (en) | Cosmetic composition containing an extract of elm tree for preventing skin aging | |
| CN114948789B (en) | SOD composition with blue light resisting effect and preparation method thereof | |
| CN110897912A (en) | Allicin face-beautifying and firming essence cream and preparation method thereof | |
| CN110638685A (en) | Edible lipstick and preparation method thereof | |
| CN113384510B (en) | Fermented composition with anti-photoaging, relieving and cooling effects and preparation method and application thereof | |
| KR102310366B1 (en) | Skin external composition for anti-aging comprising cyanidin-3-o-glucoside and natto gum | |
| KR102386801B1 (en) | Cosmetic composition for skin improvement containing phyto DNA extracted from aloe vera adventitious root | |
| CN115068382A (en) | Camellia extract, preparation method thereof and application thereof in cosmetics | |
| CN110151652B (en) | Emulsion containing lotus extract and having anti-aging effect and preparation method thereof | |
| KR101363029B1 (en) | The cosmetic composition for anti-oxident and anti-aging of the skin comprising the Gelidium amansii, Undaria pinnatifida, wheat bud and Monarda horsemint | |
| KR101860110B1 (en) | Cosmetic composition for anti-oxidation containing Acaiberry extract and sprout extract | |
| JP2006282536A (en) | Super oxide-eliminating agent, free radical-eliminating agent, hydrogen peroxide-eliminating agent and external preparation for skin | |
| KR20090105492A (en) | The bleaching cosmetic composition containing Euterpe oleracea extracts as an effetive component | |
| CN114652630B (en) | Antioxidant composition with synergistic effect | |
| CN112972314B (en) | Eye repair composition and preparation method and application thereof | |
| CN114983923B (en) | A skin external composition capable of simultaneously resisting aging of internal and external sources | |
| CN112716844B (en) | Hand cream and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |