CN109431940A - A kind of skin lightening essence cream and preparation method thereof - Google Patents
A kind of skin lightening essence cream and preparation method thereof Download PDFInfo
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- CN109431940A CN109431940A CN201811583101.0A CN201811583101A CN109431940A CN 109431940 A CN109431940 A CN 109431940A CN 201811583101 A CN201811583101 A CN 201811583101A CN 109431940 A CN109431940 A CN 109431940A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of skin lightening essence creams and preparation method thereof.The skin lightening essence cream, by weight percentage, including the following raw material: moisturizer 22~34%, emollient 15~30%, emulsifier 10~25%, antioxidant 0.5~2%, preservative 0.5~2%, skin conditioning agent 10~24%, colorant 0~1%, water surplus；Wherein, the skin conditioning agent includes bermuda lily extract and grape berry extract, and the weight ratio of the bermuda lily extract and the grape berry extract is 0.1~0.5:1.Each materials safety of skin lightening essence cream provided by the invention, mild, efficient, no skin irritation；Have the function of synergy between each raw material component, substantially increase the function and effect of one-component, reaches the concertedness of multiple-effect unification；Skin lightening essence cream provided by the invention has the function of the dim mute, bright color of very strong removal and is effectively improved skin quality, uneven suitable for facial mask and parts of body melanin deposition, the colour of skin and crowd the problems such as skin is intense darkness without light, dark yellow uses.
Description
Technical field
The present invention relates to cosmetic technical field, in particular to a kind of skin lightening essence cream and preparation method thereof.
Background technique
With the continuous improvement of people's living standards, demand of the people to health-care and skin-care product is also continuously improved.In recent years,
Skin lightening product market development is rapid, becomes one of main product of skin-care cosmetics.People are while pursuing U.S., increasingly
More emphasis is natural, safe and effective skin lightening product.Effect ingredient in white-skinned face function cosmetics mainly inhibits tyrosinase
Activity.There are the substances such as arbutin, vitamin C, salicylic acid in the skin lightening ingredient in skin lightening product in the market, mildness is poor, long
Phase use can generate the adverse effects such as stimulation, allergy to skin.Therefore, exploitation has good safety, stability, skin lightening result
The obvious and good skin lightening product of cost performance, it has also become one of the main direction of studying of current medicine and cosmetic industry has
Extraordinary development prospect.
Summary of the invention
The purpose of the present invention is intended to provide a kind of skin lightening essence cream and preparation method thereof, to solve the above technical problems.
To achieve the goals above, the technical solution of the present invention is as follows:
In a first aspect, a kind of skin lightening essence cream provided by the invention, by weight percentage, including the following raw material: moisturizing
Agent 22~34%, emollient 15~30%, emulsifier 10~25%, antioxidant 0.5~2%, preservative 0.5~2%, skin
Conditioner 10~24%, colorant 0~1%, water surplus；Wherein, the skin conditioning agent includes bermuda lily extract and Portugal
The weight ratio of grape berry extract, the bermuda lily extract and the grape berry extract is 0.1~0.5:1.
Preferably, the moisturizer is selected from least one of polyethylene glycol, propylene glycol, Sodium Hyaluronate, glycerol.
It is further preferred that the moisturizer includes polyethylene glycol, propylene glycol and Sodium Hyaluronate, the polyethylene glycol,
The propylene glycol and the weight ratio of the Sodium Hyaluronate are 1~2:1~5:0.05~0.5.
Preferably, the emollient be selected from cyclomethicone, Nexbase 2004, tridecanol trimellitate,
At least one of dimethyl silicone polymer/methyl polysilicone alkyl copolymer.
It is further preferred that the emollient includes cyclomethicone, Nexbase 2004, the inclined benzene three of tridecanol
Acid esters and dimethyl silicone polymer/methyl polysilicone alkyl copolymer, the cyclomethicone, Nexbase 2004,13
Alkanol trimellitate and dimethyl silicone polymer/methyl polysilicone alkyl copolymer mass ratio are 0.5~2:0.5~5:0.5
~2:1~3.
Preferably, the antioxidant is tocopherol.
Preferably, the emulsifier is selected from least one of cetostearyl alcohol, acrylamide/ammonium acrylate copolymer.
Preferably, the preservative in methyl hydroxybenzoate, Nipasol, Phenoxyethanol, Sensiva SC50 at least
It is a kind of.
Preferably, the skin lightening essence cream, by weight percentage, including the following raw material: moisturizer 22~29%, moisturizing
Agent 24~27%, emulsifier 16~22%, antioxidant 1~1.5%, preservative 0.7~1%, skin conditioning agent 13.8~
20%, colorant 0.24~0.5%, water surplus；Wherein, the skin conditioning agent includes that bermuda lily extract and grape fruit mention
Take object, the weight ratio of the bermuda lily extract and the grape berry extract is 0.1~0.3:1.
Second aspect, a kind of preparation method of skin lightening essence cream as described in relation to the first aspect provided by the invention, including such as
Lower step:
(1) water, moisturizer, preservative, antioxidant are added in blender, to be warming up under 10~60r/min revolving speed
75~85 DEG C, continue insulated and stirred to being thoroughly mixed；
(2) after being cooled to not higher than 45 DEG C, emollient, skin conditioning agent is added in blender, continued with 10~60r/
Min revolving speed is stirred to being thoroughly mixed；
(3) emulsifier is added in blender, is stirred with 10~60r/min revolving speed to being thoroughly mixed；
(5) it adds a colorant in blender, is stirred evenly with 10~60r/min revolving speed.
Compared with prior art, the beneficial effects of the present invention are:
Each materials safety of skin lightening essence cream provided by the invention, mild, efficient, no skin irritation；Each raw material component
Between have the function of synergy, substantially increase the function and effect of one-component, reach multiple-effect unification concertedness；This hair
The skin lightening essence cream of bright offer has the function of the dim mute, bright color of very strong removal and is effectively improved skin quality, is suitable for facial mask
And the crowd for the problems such as parts of body melanin deposition, the colour of skin are uneven and skin is intense darkness without light, dark yellow uses.
Specific embodiment
Specific embodiments of the present invention will be further explained below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but and does not constitute a limitation of the invention.In addition, invention described below
Technical characteristic involved in each embodiment can be combined with each other as long as they do not conflict with each other.
In a first aspect, a kind of skin lightening essence cream provided by the invention, by weight percentage, including the following raw material: moisturizing
Agent 22~34%, emollient 15~30%, emulsifier 10~25%, antioxidant 0.5~2%, preservative 0.5~2%, skin
Conditioner 10~24%, colorant 0~1%, water surplus；Wherein, the skin conditioning agent includes bermuda lily extract and Portugal
The weight ratio of grape berry extract, the bermuda lily extract and the grape berry extract is 0.1~0.5:1.
In embodiments of the present invention, the moisturizer is in polyethylene glycol, propylene glycol, Sodium Hyaluronate, glycerol
It is at least one.
Further, the moisturizer includes polyethylene glycol, propylene glycol and Sodium Hyaluronate, the polyethylene glycol, described
Propylene glycol and the weight ratio of the Sodium Hyaluronate are 1~2:1~5:0.05~0.5.
In embodiments of the present invention, the emollient is selected from cyclomethicone, Nexbase 2004, tridecanol
At least one of trimellitate, dimethyl silicone polymer/methyl polysilicone alkyl copolymer.
Further, the emollient includes cyclomethicone, Nexbase 2004, tridecanol trimellitate
With dimethyl silicone polymer/methyl polysilicone alkyl copolymer, the cyclomethicone, Nexbase 2004, tridecanol
Trimellitate and dimethyl silicone polymer/methyl polysilicone alkyl copolymer mass ratio are 0.5~2:0.5~5:0.5~2:1
~3.
In embodiments of the present invention, the antioxidant is tocopherol.
In embodiments of the present invention, the emulsifier is in cetostearyl alcohol, acrylamide/ammonium acrylate copolymer
At least one.
In embodiments of the present invention, the preservative is selected from methyl hydroxybenzoate, Nipasol, Phenoxyethanol, ethylhexyl
At least one of glycerol.
In embodiments of the present invention, the colorant is lemon yellow.
In embodiments of the present invention, the skin lightening essence cream, by weight percentage, including the following raw material: moisturizer
22~29%, emollient 24~27%, emulsifier 16~22%, antioxidant 1~1.5%, preservative 0.7~1%, skin tune
Manage agent 13.8~20%, colorant 0.24~0.5%, water surplus；Wherein, the skin conditioning agent includes bermuda lily extract
With grape berry extract, the weight ratio of the bermuda lily extract and the grape berry extract is 0.1~0.3:1.
In embodiments of the present invention, the bermuda lily extract is to be made using following methods:
It after bermuda lily raw material drying, crushing, is fitted into the continuous phase transistion extraction kettle for filling extractant, is being consistently lower than
Under conditions of the critical pressure and critical-temperature of extractant, by extractant boil down to liquid, in 50~70 DEG C of extraction temperature, extraction
Under conditions of 0.3~2Mpa of pressure, extraction kettle is flowed through with the flow velocity of 80~160L/h, 50~120min of continuous extraction extracts tea
It after polyphenol, flows through in extraction-container, 60~75 DEG C of resolution temperature, parses 0.08~0.5Mpa of pressure, extractant passes through heating, decompression
Mutually become gas, then by compressing immediately, becomes liquid and pass through extraction kettle, material is extracted again, so circulation repeatedly, obtains
To bermuda lily extracting solution, then vacuum freeze drying obtains bermuda lily extract；Wherein, the extractant is ethyl alcohol and second
The volume ratio of the mixed liquor of acetoacetic ester, the ethyl alcohol and the ethyl acetate is 1~3:1.
In embodiments of the present invention, the grape berry extract is to be made using following methods:
After the freeze-drying of grape fruit raw material, crushing, it is fitted into the continuous phase transistion extraction kettle for filling extractant, it is low always
Under conditions of the critical pressure and critical-temperature of extractant, by extractant boil down to liquid, in 60~85 DEG C of extraction temperature, extraction
Under conditions of 0.3~1.5Mpa of pressure power, extraction kettle is flowed through with the flow velocity of 60~120L/h, 30~90min of continuous extraction, it
Afterwards, it flows through in extraction-container, 70~90 DEG C of resolution temperature, parses 0.08~0.5Mpa of pressure, extractant passes through heating, decompression phase transformation
For gas, then by compressing immediately, becomes liquid and pass through extraction kettle, material is extracted again, so circulation repeatedly, obtains Portugal
Grape fruit extracting solution, then vacuum freeze drying obtains grape berry extract；Wherein, the extractant is the aqueous solution of ethyl alcohol, institute
The mass concentration for stating ethyl alcohol in the aqueous solution of ethyl alcohol is 70~90%.
Second aspect, a kind of preparation method of skin lightening essence cream as described in relation to the first aspect provided by the invention, including such as
Lower step:
(1) water, moisturizer, preservative, antioxidant are added in blender, to be warming up under 10~60r/min revolving speed
75~85 DEG C, continue insulated and stirred to being thoroughly mixed；
(2) after being cooled to not higher than 45 DEG C, emollient, skin conditioning agent is added in blender, continued with 10~60r/
Min revolving speed is stirred to being thoroughly mixed；
(3) emulsifier is added in blender, is stirred with 10~60r/min revolving speed to being thoroughly mixed；
(5) it adds a colorant in blender, is stirred evenly with 10~60r/min revolving speed.
Embodiment is described further below.
Bermuda lily extract in following embodiment and comparative example is to be made using following methods:
After bermuda lily raw material drying to moisture content is not higher than 5%, 50 mesh are crushed to, by smashed bermuda lily
It is fitted into the continuous phase transistion extraction kettle for filling extractant, in the critical pressure of consistently lower than extractant and the condition of critical-temperature
Under, by extractant boil down to liquid, under conditions of 60 DEG C of extraction temperature, extracting pressure 1.2Mpa, with the flow velocity stream of 100L/h
Through extraction kettle, continuous extraction 90min is flowed through in extraction-container, 70 DEG C of resolution temperature after extracting tea polyphenols, parses pressure 0.3Mpa,
Extractant mutually becomes gas by heating, decompression, then by compressing immediately, becomes liquid and pass through extraction kettle, again to material
Extraction, so circulation repeatedly, obtain bermuda lily extracting solution, then vacuum freeze drying obtains bermuda lily extract；Wherein,
The extractant is the mixed liquor of ethyl alcohol and ethyl acetate, and the volume ratio of the ethyl alcohol and the ethyl acetate is 2.5:1.
Grape berry extract in following embodiment and comparative example is to be made using following methods:
Grape fruit raw material is freeze-dried after being not higher than 10% to moisture content, is crushed to 50 mesh, loading fills extractant
Continuous phase transistion extraction kettle in, under conditions of the critical pressure of consistently lower than extractant and critical-temperature, extractant is compressed
Extraction kettle, continuous extraction are flowed through with the flow velocity of 90L/h under conditions of 70 DEG C of extraction temperature, extracting pressure 1.0Mpa for liquid
60min is flowed through in extraction-container later, 85 DEG C of resolution temperature, parses pressure 0.25Mpa, extractant passes through heating, decompression phase transformation
For gas, then by compressing immediately, becomes liquid and pass through extraction kettle, material is extracted again, so circulation repeatedly, obtains Portugal
Grape fruit extracting solution, then vacuum freeze drying obtains grape berry extract；Wherein, the extractant is the aqueous solution of ethyl alcohol, institute
The mass concentration for stating ethyl alcohol in the aqueous solution of ethyl alcohol is 80%.
Embodiment 1
A kind of preparation method of skin lightening essence cream provided in this embodiment, includes the following steps:
Weigh raw material according to the following weight percentages: polyethylene glycol 8.0%, propylene glycol 18.0%, Sodium Hyaluronate 2.4%,
Cyclomethicone 4.5%, Nexbase 2004 9.0%, tridecanol trimellitate 4.5%, dimethyl silicone polymer/
Methyl polysilicone alkyl copolymer 9.0%, cetostearyl alcohol 10.0%, acrylamide/ammonium acrylate copolymer 6.0%, tocopherol
1.0%, methyl hydroxybenzoate 0.1%, Nipasol 0.1%, Phenoxyethanol 0.4%, Sensiva SC50 0.1%, bermuda lily mention
Take object 4.0%, grape berry extract 16.0%, lemon yellow 0.24%, water surplus.
Water, polyethylene glycol, propylene glycol, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, ethylhexyl is sweet
Oil, tocopherol are added in blender, to be warming up to 80 DEG C under 30r/min revolving speed, continue insulated and stirred to being thoroughly mixed；It is cooled to
After 45 DEG C, by cyclomethicone, Nexbase 2004, tridecanol trimellitate, dimethyl silicone polymer/
Methyl polysilicone alkyl copolymer, bermuda lily extract, grape berry extract are added in blender, continue with 50r/min revolving speed
Stirring is to being thoroughly mixed；Cetostearyl alcohol, acrylamide/ammonium acrylate copolymer are added in blender, with 60r/min revolving speed
Stirring is to being thoroughly mixed；Lemon yellow is added in blender, is stirred evenly with 40r/min revolving speed.
Embodiment 2
A kind of preparation method of skin lightening essence cream provided in this embodiment, includes the following steps:
Weigh raw material according to the following weight percentages: polyethylene glycol 10.0%, propylene glycol 10.0%, Sodium Hyaluronate 2.0%,
Cyclomethicone 5.0%, Nexbase 2004 5.0%, tridecanol trimellitate 5.0%, dimethyl silicone polymer/
Polymethyl siloxane copolymer 1 0.0%, cetostearyl alcohol 12.0%, acrylamide/ammonium acrylate copolymer 8.0%, tocopherol
1.0%, methyl hydroxybenzoate 0.2%, Nipasol 0.1%, Phenoxyethanol 0.2%, Sensiva SC50 0.2%, bermuda lily mention
Take object 4.5%, grape berry extract 15.0%, lemon yellow 0.40%, water surplus.According to the system similar with the embodiment of the present invention 1
Skin lightening essence cream is made in Preparation Method.
Embodiment 3
A kind of preparation method of skin lightening essence cream provided in this embodiment, includes the following steps:
Weigh raw material according to the following weight percentages: polyethylene glycol 8.0%, propylene glycol 20.0%, Sodium Hyaluronate 1.0%,
Cyclomethicone 4.0%, 10.0% tridecanol trimellitate 4.0% of Nexbase 2004, dimethyl silicone polymer/
Methyl polysilicone alkyl copolymer 6.0%, cetostearyl alcohol 8.0%, acrylamide/ammonium acrylate copolymer 12.0%, tocopherol
1.2%, methyl hydroxybenzoate 0.2%, Nipasol 0.2%, 0.5% Sensiva SC50 0.1% of Phenoxyethanol, bermuda lily are extracted
Object 1.5%, grape berry extract 15.0%, lemon yellow 0.30%, water surplus.According to the preparation similar with the embodiment of the present invention 1
Skin lightening essence cream is made in method.
Embodiment 4
The reparation crystalline flour of the present embodiment by weight percentage, including the following raw material: polyethylene glycol 4.8%, propylene glycol
17.2%, the inclined benzene three of Sodium Hyaluronate 2.0%, cyclomethicone 4.0%, Nexbase 2004 12.0%, tridecanol
Acid esters 4.0%, dimethyl silicone polymer/methyl polysilicone alkyl copolymer 6.0%, cetostearyl alcohol 16.0%, acrylamide/the third
Olefin(e) acid ammonium copolymer 6.0%, tocopherol 1.5%, methyl hydroxybenzoate 0.1%, Nipasol 0.1%, Phenoxyethanol 0.3%, ethyl
0.2% bermuda lily extract 1.8% of hexyl glycerol, grape berry extract 12.0%, lemon yellow 0.50%, water surplus.According to
Skin lightening essence cream is made in the preparation method similar with the embodiment of the present invention 1.
Embodiment 5
The reparation crystalline flour of the present embodiment by weight percentage, including the following raw material: polyethylene glycol 8.0%, propylene glycol
18.0%, Sodium Hyaluronate 2.4%, cyclomethicone 2.5%, Nexbase 2004 5.0%, tridecanol trimellitic acid
Ester 2.5%, dimethyl silicone polymer/methyl polysilicone alkyl copolymer 5.0%, cetostearyl alcohol 15.0%, acrylamide/propylene
Sour ammonium copolymer 1 0.0%, tocopherol 0.5%, methyl hydroxybenzoate 0.1%, Nipasol 0.1%, Phenoxyethanol 0.2%, ethyl hexyl
Base glycerol 0.1%, bermuda lily extract 8.0%, grape berry extract 16.0%, lemon yellow 0.24%, water surplus.According to
Skin lightening essence cream is made in the similar preparation method of the embodiment of the present invention 1.
Embodiment 6
A kind of skin lightening essence cream provided in this embodiment, by weight percentage, including the following raw material: polyethylene glycol
10.0%, propylene glycol 20.0%, Sodium Hyaluronate 4.0%, cyclomethicone 5.0%, Nexbase 2004 10.0%, ten
Three alkanol trimellitates 5.0%, dimethyl silicone polymer/polymethyl siloxane copolymer 1 0.0%, cetostearyl alcohol
5.0%, acrylamide/ammonium acrylate copolymer 5.0%, tocopherol 2.0%, methyl hydroxybenzoate 0.2%, Nipasol 0.2%, benzene
Oxyethanol 0.8%, Sensiva SC50 0.2%, bermuda lily extract 2.0%, grape berry extract 8.0%, lemon yellow
0.24%, water surplus.Skin lightening essence cream is made according to the preparation method similar with the embodiment of the present invention 1.
Comparative example 1
Beneficial effect in order to further illustrate the present invention, this comparative example weigh following raw materials by weight percentage:
Polyethylene glycol 8.0%, propylene glycol 18.0%, Sodium Hyaluronate 2.4%, cyclomethicone 4.5%, Nexbase 2004
9.0%, tridecanol trimellitate 4.5%, dimethyl silicone polymer/methyl polysilicone alkyl copolymer 9.0%, cetearyl alcohol
Alcohol 10.0%, acrylamide/ammonium acrylate copolymer 6.0%, tocopherol 1.0%, methyl hydroxybenzoate 0.1%, Nipasol
0.1%, Phenoxyethanol 0.4%, Sensiva SC50 0.1%, grape berry extract 20.0%, lemon yellow 0.24%, water surplus.
Skin lightening essence cream is made according to the preparation method similar with the embodiment of the present invention 1.
Comparative example 2
Beneficial effect in order to further illustrate the present invention is made according to the preparation method similar with the embodiment of the present invention 1
The difference of skin lightening essence cream, this comparative example and embodiment 1 is only that: the grape berry extract of this comparative example and bermuda lily are extracted
Object is to take water as a solvent to be made using conventional soxhlet type method.
1 skin irritation test of effect example
New zealand rabbit, half male and half female are chosen, weight 2.5Kg is randomly divided into 8 groups, and every group 10, each group is smeared pair respectively
Answer product obtained by embodiment and comparative example.New zealand rabbit back backbone side is lost hair or feathers in first 24 hours of test, and unhairing range is right
Side 3cm × 3cm.Going through whether skin of unhairing is damaged because of unhairing before to given the test agent, the skin haveing damage is unsuitable
It is tested.Tested new zealand rabbit is fixed in rabbit fixed bin, is applied to right side plucked skin with 0.5g test material
On skin, application area is 2.5cm × 2.5cm, is smeared daily once, continuous to smear 14 days, since the 2nd day, before smearing every time
Cropping is answered, clears up remaining given the test agent with warm water, observation is as a result, and carry out skin wound repair Scoring System after 1 hour.
(1) standards of grading of skin wound repair are as follows: 1. without erythema: 0 point；2. slight erythema (visible reluctantly): 1 point；
3. moderate erythema (clearly visible): 2 points；4. severe erythema: 3 points；5. aubergine erythema is formed to slight eschar: 4 points；6. water
It is swollen: 0 point；7. Mild edema (visible reluctantly): 1 point；8. intermediate edema (obvious protuberance): 2 points；9. severe edema's (cutaneous protuberance
1mm, clear-cut): 3 points；10. Severe edema (cutaneous protuberance is more than 1mm, and has expansion): 4 points.
(2) grade scale of skin irritatin intensity is as follows: 1. skin irritation index is 0~0.49: nonirritant；2. skin
Stimulus index is 0.5~1.99: slight stimulation；3. skin irritation index is 2.0~5.99: moderate irritation；4. skin pierces
Swashing index is 6.0~8.0: severe irritation.
(3) test result is as shown in table 1:
The skin irritation test result of each skin lightening essence cream of table 1
| Group | Rule of origin | Skin irritatin scoring | Skin irritatin strength grading |
| 1 | Embodiment 1 | 0 | It is nonirritant |
| 2 | Embodiment 2 | 0 | It is nonirritant |
| 3 | Embodiment 3 | 0 | It is nonirritant |
| 4 | Embodiment 4 | 0 | It is nonirritant |
| 5 | Embodiment 5 | 0 | It is nonirritant |
| 6 | Embodiment 6 | 0 | It is nonirritant |
| 7 | Comparative example 1 | 0 | It is nonirritant |
| 8 | Comparative example 2 | 0 | It is nonirritant |
Interpretation of result: the test result of table 1 shows that product property provided by the embodiment of the present invention and comparative example is mild,
It is highly-safe without skin irritation.
Effect example 2
In order to which the skin lightening essence cream for showing of the invention has the function of effectively improving skin brightness, by above-described embodiment and right
The product of ratio preparation carries out following clinical trial:
80 female volunteers are chosen, the age 20~50 years old, are uniformly divided into 8 groups, respectively to Examples 1 to 6 and comparative example 1
The product prepared in~2 is tested, and test position is facial cheek region, and application method is once in the morning and once at night, continuously
It uses 28 days.
Skin brightness (unit SGU) is measured with skinanalysis apparatus, before the said goods, is measured with skinanalysis apparatus to be measured
Area skin brightness measures the area skin brightness (skin with skinanalysis apparatus respectively when test carries out the 7th, 14,21,28 day
Skin brightness measuring 3 times, take its average value as skin brightness reference data), thus calculate skin brightness change rate (skin brightness
Change rate=(skin brightness after skin brightness-test before testing)/skin brightness × 100% before testing), test result such as table 2
It is shown.
The skin of each skin lightening essence cream of table 2 measures test result
Interpretation of result: available to draw a conclusion from above-mentioned test result: compared with embodiment 5~6 and comparative example 1~2, this
The skin lightening essence cream that inventive embodiments 1~4 provide has more significant effect for bright color, and test carries out the 7th day, skin
Brightness improves 11.3% or more；Test carries out the 14th day, and skin brightness improves 26.3% or more；Test carries out the 28th
It, skin brightness improves 30.2% or more；Test carries out 28 days, uses the tester of the skin lightening essence cream of Examples 1 to 4
Skin brightness balanced growth 39%.
Above the embodiments of the present invention are described in detail, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (10)
1. a kind of skin lightening essence cream, which is characterized in that by weight percentage, including the following raw material: moisturizer 22~34%, profit
Skin agent 15~30%, emulsifier 10~25%, antioxidant 0.5~2%, preservative 0.5~2%, skin conditioning agent 10~
24%, colorant 0~1%, water surplus；Wherein, the skin conditioning agent includes bermuda lily extract and grape berry extract,
The weight ratio of the bermuda lily extract and the grape berry extract is 0.1~0.5:1.
2. skin lightening essence cream according to claim 1, which is characterized in that the moisturizer be selected from polyethylene glycol, propylene glycol,
At least one of Sodium Hyaluronate and glycerol.
3. skin lightening essence cream according to claim 2, which is characterized in that the moisturizer includes polyethylene glycol, propylene glycol
And Sodium Hyaluronate, the weight ratio of the polyethylene glycol, the propylene glycol and the Sodium Hyaluronate are 1~2:1~5:0.05
~0.5.
4. skin lightening essence cream according to claim 1, which is characterized in that the emollient is selected from ring polydimethylsiloxanes
At least one in alkane, Nexbase 2004, tridecanol trimellitate, dimethyl silicone polymer/methyl polysilicone alkyl copolymer
Kind.
5. skin lightening essence cream according to claim 4, which is characterized in that the emollient includes ring polydimethylsiloxanes
Alkane, Nexbase 2004, tridecanol trimellitate and dimethyl silicone polymer/methyl polysilicone alkyl copolymer, the ring are poly-
Dimethyl siloxane, Nexbase 2004, tridecanol trimellitate and dimethyl silicone polymer/methyl polysilicone alkyl copolymer
Mass ratio be 0.5~2:0.5~5:0.5~2:1~3.
6. skin lightening essence cream according to claim 1, which is characterized in that the antioxidant is tocopherol.
7. skin lightening essence cream according to claim 1, which is characterized in that the emulsifier is selected from cetostearyl alcohol, propylene
At least one of amide/ammonium acrylate copolymer.
8. skin lightening essence cream according to claim 1, which is characterized in that the preservative is selected from methyl hydroxybenzoate, oxybenzene third
At least one of ester, Phenoxyethanol, Sensiva SC50.
9. skin lightening essence cream according to claim 1, which is characterized in that the skin lightening essence cream, by weight percentage,
Including the following raw material: moisturizer 22~29%, emulsifier 16~22%, antioxidant 1~1.5%, is prevented emollient 24~27%
Rotten agent 0.7~1%, skin conditioning agent 13.8~20%, colorant 0.24~0.5%, water surplus；Wherein, the skin condition
Agent includes bermuda lily extract and grape berry extract, the weight of the bermuda lily extract and the grape berry extract
Than for 0.1~0.3:1.
10. a kind of preparation method of such as skin lightening essence cream according to any one of claims 1 to 9, which is characterized in that including such as
Lower step:
(1) water, moisturizer, preservative, antioxidant are added in blender, be warming up to 75 under 10~60r/min revolving speed~
85 DEG C, continue insulated and stirred to being thoroughly mixed；
(2) after being cooled to not higher than 45 DEG C, emollient, skin conditioning agent are added in blender, continue to turn with 10~60r/min
Speed stirring is to being thoroughly mixed；
(3) emulsifier is added in blender, is stirred with 10~60r/min revolving speed to being thoroughly mixed；
(5) it adds a colorant in blender, is stirred evenly with 10~60r/min revolving speed.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811583101.0A CN109431940A (en) | 2018-12-24 | 2018-12-24 | A kind of skin lightening essence cream and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811583101.0A CN109431940A (en) | 2018-12-24 | 2018-12-24 | A kind of skin lightening essence cream and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464672A (en) * | 2019-09-09 | 2019-11-19 | 上海新高姿化妆品有限公司 | A kind of cosmetic composition with safe antioxidant effect |
-
2018
- 2018-12-24 CN CN201811583101.0A patent/CN109431940A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 广州亿肽生物科技有限公司: "亿肽百合亮肤精华霜", 《国产非特殊用途化妆品备案信息服务平台》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464672A (en) * | 2019-09-09 | 2019-11-19 | 上海新高姿化妆品有限公司 | A kind of cosmetic composition with safe antioxidant effect |
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Application publication date: 20190308 |