KR20130023324A - Cosmetic composition comprising of the mixed herb fermentation extracts - Google Patents
Cosmetic composition comprising of the mixed herb fermentation extracts Download PDFInfo
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- KR20130023324A KR20130023324A KR1020130016657A KR20130016657A KR20130023324A KR 20130023324 A KR20130023324 A KR 20130023324A KR 1020130016657 A KR1020130016657 A KR 1020130016657A KR 20130016657 A KR20130016657 A KR 20130016657A KR 20130023324 A KR20130023324 A KR 20130023324A
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- cosmetic composition
- soybean
- mistletoe
- fermented extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
Abstract
Description
The present invention is a soybean (Soybean), mistletoe ( Viscum Album ), with the root of the hair ( Imperata Cylindrica ) The present invention relates to a cosmetic composition having an excellent moisturizing and soothing effect, comprising the fermented extract as an active ingredient, and more specifically, to the fermentation microorganism Saccharomyces cerevisiae ) or Lactobacillus spp . The present invention relates to a cosmetic composition (trade name: Natural HG or NHG) having excellent moisturizing and soothing effect, containing a fermentation extract obtained by extracting and mixing the first solid fermentation and the second liquid fermentation using).
Patent Document: Korean Application No. 10-2001-0022014
Therefore, the present inventors have tried to find a method to obtain the active ingredient in the highest possible yield than the prior art and to apply it to cosmetics, the method of producing soybean, mistletoe, hair root fermentation extract of the present invention is an antioxidant component It is to provide a cosmetic composition exhibiting abundant concentration of the active ingredient and applying it to cosmetics to exhibit the moisturizing effect, soothing effect, anti-allergic effect and anti-inflammatory effect of the present invention.
The objects and advantages of the present invention will become apparent from the following detailed description and claims.
In order to achieve the above object, the present invention provides a cosmetic composition containing a fermented extract obtained by extracting and filtering the first solid fermentation and the second liquid fermentation of soybean, mistletoe and hair root using yeast or lactic acid bacteria, respectively. .
Preferably, the fermentation is a soybean, mistletoe, hair root is a bacterium selected from the group consisting of yeast, lactic acid bacteria, Bacillus bacteria or mixtures thereof while maintaining a pH of 5 to 7 under temperature conditions of 20 to 40 ℃, 1 to 7 days It provides a cosmetic composition, characterized in that obtained by fermentation.
In addition, the yeast is preferably provided a cosmetic composition, characterized in that Saccharomyces cerevisisae (Saccharomyces cerevisisae).
In addition, the extraction process preferably provides a cosmetic composition, characterized in that obtained by treating for 1 to 24 hours at a temperature of 40 to 90 ℃.
Further, preferably, the extract is a solvent selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane, chloroform, ethyl ether, butylene glycol, hexane and mixtures thereof. It provides a cosmetic composition, characterized in that the extraction using.
In addition, the soybean, mistletoe, hair root fermentation extract is characterized in that it is contained in an amount of 0.0001 to 30.0% by weight based on the total weight of the cosmetic composition.
In addition, the cosmetic composition preferably provides a cosmetic composition characterized in that it exhibits a moisturizing effect, soothing effect, anti-allergic effect and anti-inflammatory effect.
The cosmetic composition according to the present invention contains active ingredients of soybean, mistletoe and hair root fermentation extract, and has no skin irritation, and has good solubility, affinity, and stability to various bases and additives for cosmetics, organic solvents, and the like. And skin soothing effect was excellent.
The present invention provides a cosmetic composition containing a fermented extract consisting of soybean, mistletoe, hair root obtained by fermenting soybean, mistletoe and hair root, respectively, after extraction and filtration.
According to the invention, the fermented extract consisting of soybean, mistletoe, hair root is excellent in anti-inflammatory effect.
Therefore, the cosmetic composition of the present invention comprising a fermented extract consisting of soybean, mistletoe, hair root having various functions as an active ingredient can be usefully used with excellent anti-allergic effect.
1 is a graph showing the erythema relief effect of the cream containing a fermented extract consisting of soybean, mistletoe, hair roots according to the present invention,
Figure 2 is a graph showing the moisturizing effect over time of the fermented extract consisting of soybean, mistletoe, hair root according to the present invention,
Figure 3 is a graph showing the skin moisture retention rate over time of the fermented extract consisting of soybean, mistletoe, hair root according to the present invention,
Figure 4 is a graph showing the skin soothing and anti-inflammatory effect according to the concentration of the fermented extract consisting of soybean, mistletoe, hair roots according to the present invention,
Figure 5 is a graph showing the anti-inflammatory effect of another form according to the concentration of the fermented extract consisting of soybean, mistletoe, hair roots according to the present invention,
Figure 6 is a graph showing the anti-allergic effect according to the concentration of the fermented extract consisting of soybean, mistletoe, hair roots according to the present invention
Figure 4 is a graph showing the skin soothing and anti-inflammatory effect according to the concentration of the fermented extract consisting of soybean, mistletoe, hair roots according to the present invention,
Figure 5 is a graph showing the anti-inflammatory effect of another form according to the concentration of the fermented extract consisting of soybean, mistletoe, hair roots according to the present invention,
Figure 6 is a graph showing the anti-allergic effect according to the concentration of the fermented extract consisting of soybean, mistletoe, hair roots according to the present invention
The present invention relates to a cosmetic composition having excellent moisturizing and soothing effects, comprising a fermented extract consisting of soybean, mistletoe and hair root obtained by fermenting, extracting and filtering soybean, mistletoe and hair root, respectively. Moisturizing fermentation extract containing fermented extract consisting of soybean, mistletoe and hair root with increased physiologically active substance as fermentation using fermentation microorganism selected from the group consisting of lactic acid bacteria, Bacillus bacteria, and mixtures thereof. A cosmetic composition with excellent soothing effect has been developed.
The cosmetic composition of the present invention as described above is a cosmetic composition with excellent moisturizing and soothing effect, containing a fermentation extract consisting of soybean, mistletoe, hair root obtained by fermenting soybean, mistletoe, hair root and then extracted and filtered.
Fermented extract consisting of soybean, mistletoe, hair root of the present invention composed of the above components is excellent for moisturizing effect and suitable for use as a raw material of the cosmetic composition.
The present inventors extracted and filtered after fermenting soybean, mistletoe and hair root, respectively, in order to find a method to obtain a bioactive substance having various efficacies, especially in the highest yield through a filtration process. It was confirmed that the content of the active ingredient is increased through the process, and applied to the cosmetic to confirm that there is a moisturizing effect to complete the present invention.
Soybean, mistletoe, hair root contained in the cosmetic composition of the present invention is characterized in that consisting of 1 to 50 parts by weight, 1 to 50 parts by weight of mistletoe, 1 to 50 parts by weight of the hair roots based on dry weight and composed of a combination thereof The mixture is a bacterium selected from the group consisting of yeast, lactic acid bacteria, Bacillus bacteria or mixtures thereof, which can be obtained by solid fermentation and liquid fermentation for 1 to 7 days while maintaining pH 5 to 7 under temperature conditions of 20 to 40 ℃. More preferably, it is fermented using Saccharomyces cerevisisae, and most preferably, it is fermented using Saccharomyces cerevisiae KCTC 7904 strain.
Soybean, mistletoe, hair root used in the present invention is used to dry soybean, mistletoe, hair root prepared by a generally known method, they are made of fine powder to pass through 300 mesh size after sufficient washing and dry grinding To primary cultures by primary solid culture at a temperature of 40 to 60 ℃ for 12 to 24 hours. 100 g / L of soybean, mistletoe and hair roots are added to Saccharomyces genus (Saccharomyces cerevisia KCTC 7904) strain culture. 1 to 4% of glucose is used as the carbon source, preferably 1 to 2% is added, 0.1 to 1% of peptone is added, and preferably 0.2 to 0.5% is further added to the second liquid culture. The culture was incubated for 1 to 7 days using a 5L fermenter while maintaining a pH of 5 to 7, under a temperature condition of 20 to 40 ℃. After the culture is characterized in that the culture medium is first removed by centrifugation.
Also preferably, the extraction is performed for 1 to 24 hours at a temperature of 40 to 90 ℃, preferably 12 to 24 hours at a temperature of 40 to 60 ℃, most preferably at a temperature of 50 ℃ Process for 24 hours.
Also preferably, the extraction solvent is selected from the group consisting of purified water, methanol, ethanol, glycerine, ethyl acetate, butylene glycol, propylene glycol, dichloromethane, chloroform, ethyl ether, butylene glycol, hexane and mixtures thereof Extracted using, more preferably extracted using ethanol, 70% aqueous ethanol or water, most preferably 70% aqueous ethanol.
After fermented extract consisting of soybean, mistletoe, and hair root extracted as described above, the mixture was extracted by refluxing three times for 5 hours by adding ethanol to the final 70% (V / V) ethanol aqueous solution, Whatman # 2 Filter with filter paper. When the filtration is completed in the present invention, the extract obtained in the extraction step is transferred to a concentration tank, concentrated under reduced pressure and freeze-dried. Concentration under reduced pressure was concentrated using a rotary vacuum concentrator and concentrated under reduced pressure for 2 hours while putting 700 ml of the extract in a 1,000 ml round flask and rotating at 50 to 70 ° C. and 600 to 1200 rpm at a pressure of 650 mmHg to 750 mmHg. The concentrated solution concentrated under reduced pressure was pre-freezing to lower the temperature to -40 ° C, maintained at -40 ° C for 2 to 4 hours, and then dropped to -80 through trap refrigeration, and the vacuum was maintained at 10-30 mTorr for 120 minutes. Raise back up to -40C. Thereafter, 240 minutes at -20 ° C, 40 minutes at 0 ° C, 340 minutes at 15 ° C, 130 minutes at 30 ° C and 1300 minutes until complete drying.
For reference, the fermented extract consisting of soybean, mistletoe, hair root is an extract obtained by treating the fermented product obtained by fermenting soybean, mistletoe, hair root after ultra high pressure, or the powder is freeze-dried after vacuum, concentration, or extract powder Compounds blended with are preferred.
In addition, the fermented extract consisting of soybean, mistletoe, hair root is not limited to a specific range, but preferably 0.0001 to 30% by weight relative to the total weight of the cosmetic composition. If the content of the extract is less than 0.0001% by weight, the moisturizing effect does not appear, when more than 30% by weight of the effect of increasing the effect of the content is insignificant, there is a problem in the safety and stability of the formulation and is not economical.
Ingredients included in the cosmetic composition of the present invention as an active ingredient includes components conventionally used in cosmetic compositions in addition to the active ingredient, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors, And carriers.
Cosmetic compositions of the present invention may be prepared in any formulation conventionally prepared in the art, including, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, It may be formulated as an oil, powder foundation, emulsion foundation, wax foundation, spray, and the like, but is not limited thereto.
More specifically, it can be manufactured in the form of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.
When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .
When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.
When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethyleneglycol or sorbitan.
When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, and microcrystals are used as carrier components. Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.
When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide ether. Sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
When the cosmetic composition of the present invention is a soap, surfactant-containing cleansing or surfactant-free cleansing formulation, it may be wiped off, peeled off or washed with water after application to the skin. The surfactant-containing cleansing formulation is a cleansing foam, a cleansing water, a cleansing towel, and a cleansing pack. The surfactant-free cleansing formulation may be a cleansing cream, , Cleansing lotion, cleansing water and cleansing gel, but is not limited thereto.
The cosmetic composition of the present invention can be applied to cosmetics that can help to maintain the skin's moisturizing and elasticity to improve the skin's defense in winter.
In addition, the cosmetic composition of the present invention can be applied to cosmetics in anticipation of skin soothing effect and anti-inflammatory effect.
The cosmetic method of the present invention refers to all cosmetic methods using the cosmetic composition of the present invention. That is, all the methods known in the art using the cosmetic composition belong to the makeup method of the present invention.
In addition, the present invention provides a cosmetic method that can obtain a skin moisturizing effect using a cosmetic composition comprising the soybean, mistletoe, hair root fermentation extract.
It refers to all the cosmetic methods for applying the cosmetic composition of the present invention to human skin. That is, all methods known in the art for applying the cosmetic composition to the skin belong to the cosmetic method of the present invention.
The cosmetic composition of the present invention may be used alone or in combination, or may be used by overlapping with other cosmetic compositions other than the present invention. In addition, the cosmetic composition with excellent skin moisturizing effect, soothing effect, anti-allergic effect and anti-inflammatory effect according to the present invention may be used according to a conventional method of use, and the number of times of use may vary depending on the user's skin condition or taste.
Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention, and it is to be understood by those skilled in the art that the present invention is not limited thereto It will be obvious.
<Example 1> Preparation of fermented extract consisting of soybean, mistletoe, hair root (trade name: Natural HG or NHG)
30 g of soybean, 30 g of mistletoe, and 40 g of hair roots were selected as a sample, thoroughly washed and dried, and finely ground to pass through a 300 mesh sieve, and then subjected to primary solid fermentation with Lactobacillus lactic acid bacteria at a temperature of 40 to 60 ° C for 12 hours. . Saccharomyces genus (Saccharomyces cerevisia KCTC 7904) strain culture solution was added to the primary fermentation at a level of 0.5% based on solids. 1 to 4% of glucose was used as the carbon source, preferably 2% (W / V) was added, and 0.1% of peptone was added to the culture. The culture was incubated for 5 days using a 5L fermenter while maintaining the pH at 5-7 at 37 ° C. After the culture of the microorganism, the culture was centrifuged to remove the culture. Soybean, mistletoe and hair roots from which the cultures were first removed were heated to 50 ° C. and subjected to ultra high pressure for 24 hours, followed by cooling to room temperature. Secondary fermented product consisting of ultra-high pressure soybean, mistletoe and hair roots was refluxed and refrigerated three times for 5 hours by adding ethanol to the final 70% (V / V) ethanol aqueous solution, and then
Example 2 Preparation of a Nourishing Cream Containing Fermented Extract Composed of Soybean, Mistletoe, and Hair Roots According to the Present Invention
Dissolving the purified water portion by heating it to 80 ° C., emulsifying by adding the dissolved oily part heated to 80 ° C., adding and mixing a thickener dissolved in warm water at 60 ° C., and cooling and adding and mixing cosmetic ingredients. Cooling to 30 ℃ and defoaming, performing the step of filtration and aging prepared at 50 ℃ to prepare a nutrient cream as shown in Table 1.
<
Apply the nutrient cream prepared in Example 3 (10m / 5cm 2 ) to the forearm of 40 healthy men and women (20 males and 20 females), and cover the rest with aluminum foil for 30 minutes. Subsequently, a long wavelength ultraviolet ray was irradiated at a dose of 10.2 J /
Experimental Example 2 Test for confirming calming effect of nourishing cream containing fermented extract consisting of soybean, mistletoe and hair root according to the present invention
A human patch test was performed on the nourishing cream prepared in Example 2 on the forearm of 40 healthy adult men and women (20 males, 20 females). After wiping the forearm of the subject well with 70% ethanol, the pin chamber containing 20 µl of the nourishing cream prepared in Example 2 in a common cosmetic base was closed and attached to the site 24 hours using an adhesive tape. After 24 hours, the adhesive tape and the pin chamber were removed, and the sample remaining on the skin with a gauze was lightly removed, and then the skin condition was observed, and again after 24 hours. As a result of the experiment, as shown in Figure 1 in the human patch test to confirm the skin irritation of the nourishing cream containing a fermented extract consisting of soybean, mistletoe, hair roots according to the present invention did not show a positive response to the human skin at all It was confirmed.
Experimental Example 3 Experiment for Measuring Moisturizing Effect of Fermented Extract Composed of Soybean, Mistletoe and Hair Roots According to the Present Invention
In the same manner as in
In addition, after applying the natural HG to the forearm of the fermentation extract consisting of soybean, mistletoe, hair root according to the present invention in FIG. 3 after 2, 4, 6, 8 hours, the skin moisture retention rate was measured, to confirm a significant difference Could.
Experimental Example 4 Experiment of Determination of Skin Soothing and Anti-Inflammatory Effects According to Concentration of Soybean, Mistletoe and Hair Root Fermentation Extracts According to the Present Invention
In the same manner as in
In addition, lipoxygenase (5-LO, 5-lipoxygenase) adds molecular oxygen to unsaturated fatty acids having 1,4- cis and cis- pentadiene (1,4-pentadiene) structures in the molecule, such as linoleic acid, linolenic acid, and arachidonic acid. It is an oxidase that produces 1,3- cis and trans -diene 5-hydroperoxide. It is an enzyme involved in the first reaction of leucotriene biosynthesis from arachidonic acid, which is involved in various inflammatory and allergic diseases. Therefore, by measuring the inhibitory activity of lipoxygenase using SLO (soybean lipoxygenase) similar to 5-LO structurally and mechanically, the fermentation extract consisting of soybean, mistletoe and hair roots according to the present invention has an anti-inflammatory effect. It confirmed that it was excellent.
<Experiment 5> Anti-allergic effect measurement experiment according to the concentration of soybean, mistletoe, hair root fermentation extract according to the present invention
In the same manner as in
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but on the contrary, ≪ RTI ID = 0.0 > and / or < / RTI >
Claims (7)
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101634670B1 (en) | 2015-07-27 | 2016-06-30 | 강원대학교산학협력단 | Cosmetic composition comprising fermented extract of mistletoe for anti-inflammation or anti-allergy |
CN106619379A (en) * | 2016-12-27 | 2017-05-10 | 广东芭薇生物科技股份有限公司 | Composition containing plant fermentation product as well as preparation method and application of composition |
KR20210001935A (en) | 2019-06-28 | 2021-01-06 | 강원대학교산학협력단 | Anti-allergy composition comprising mistletoe extract or fraction |
-
2013
- 2013-02-17 KR KR1020130016657A patent/KR20130023324A/en not_active Application Discontinuation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101634670B1 (en) | 2015-07-27 | 2016-06-30 | 강원대학교산학협력단 | Cosmetic composition comprising fermented extract of mistletoe for anti-inflammation or anti-allergy |
CN106619379A (en) * | 2016-12-27 | 2017-05-10 | 广东芭薇生物科技股份有限公司 | Composition containing plant fermentation product as well as preparation method and application of composition |
CN106619379B (en) * | 2016-12-27 | 2018-04-06 | 广东芭薇生物科技股份有限公司 | A kind of composition of the product containing plant fermentation and its preparation method and application |
KR20210001935A (en) | 2019-06-28 | 2021-01-06 | 강원대학교산학협력단 | Anti-allergy composition comprising mistletoe extract or fraction |
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