JP4017300B2 - Skin cosmetics and bear improving agents - Google Patents

Description

【００３５】
（１）調製法
Ａ成分とＢ成分をそれぞれ均一に溶解した後、両者を混合溶解、攪拌した。
【００３６】
（２）特性
得られたスキンローションについて諸試験を実施した結果を表１に併せて記載する。この表から明らかなように、ユズエキスとビタミンＥ誘導体を配合したスキンローションは諸試験において良好な結果であった。それに対して比較例1のスキンローションは、諸試験において顕著な効果は認められなかった。また実施例のスキンローションはヒト皮膚を用いた諸試験においても全く皮膚刺激は生じなかった。
【００３７】
実施例３〜５、比較例４〜５
下記処方に基ずき下記の調製法により皮膚化粧料を調製し、前記の諸試験を実施した。
【００３８】
実施例３ クリーム
（Ａ）
酢酸dl−α−トコフェロール 表２に記載
グリセリルモノステアレート ２．０（ｗｔ％）
蜜ろう １．０
ソルビタンモノステアレート １．０
ワセリン ４．０
流動パラフィン １２．０
（Ｂ）
ユズエキス 表２に記載
Ｎ−ステアロイル−Ｌ−グルタミン酸ナトリウム １．０
カラギーナン ０．３
メチルパラベン ０．１
精製水 残量
【００３９】
実施例４ ミルク
（Ａ）
リノール酸dl−α−トコフェロール 表２に記載
ポリオキシエチレン（２０Ｅ．Ｏ．）
ソルビタンモノオレエート ０．５（ｗｔ％）
ソルビタンセスキオレエート ０．１５
セタノール １．０
ワセリン ２．０
スクアラン ５．０
ブチルパラベン ０．１
（Ｂ）
ユズエキス 表２に記載
グリセリン １０．０
ジプロピレングリコール ５．０
メチルパラベン ０．１
キサンタンガム ０．２
セチル硫酸ナトリウム ０．３
精製水 残量、
【００４０】
実施例５ ファンデーション
（Ａ）
セタノール ３．０（ｗｔ％）
α−トコフェロール 表２に記載
ワセリン ５．０
グリセリルモノステアレート ２．５
ステアリン酸 ３．０
ブチルパラベン ２．０
ポリオキシエチレン（１０Ｅ．Ｏ．）
ステアリルエーテル １．０
（Ｂ）
ユズエキス 表２に記載
ソルビトール ５．０
１，３−ブチレングリコール ６．０
顔料 １５．０
セチル硫酸ナトリウム １．２
精製水 残量
【００４１】
比較例４ クリーム
（Ａ）
グリセリルモノステアレート ２．０（ｗｔ％）
蜜ろう １．０
ソルビタンモノステアレート １．０
ワセリン ４．０
流動パラフィン １２．０
（Ｂ）
ユズエキス 表２に記載
Ｎ−ステアロイル−Ｌ−グルタミン酸ナトリウム １．０
カラギーナン ０．３
メチルパラベン ０．１
精製水 残量
【００４２】
比較例５ ミルク
（Ａ）
ソルビタンセスキオレエート ０．１５（ｗｔ％）
酢酸dl−α−トコフェロール 表２に記載
ポリオキシエチレン（２０Ｅ．Ｏ．）
ソルビタンモノオレエート ０．５
セタノール １．０
ワセリン ２．０
スクアラン ５．０
ブチルパラベン ０．１
（Ｂ）
グリセリン １０．０
ジプロピレングリコール ５．０
メチルパラベン ０．１
キサンタンガム ０．２
セチル硫酸ナトリウム ０．３
精製水 残量
【００４３】
【表２】

【００４４】
（１）調製法
処方中のＡ成分とＢ成分を、それぞれ８０℃に加熱し均一に溶解した。ついで、Ａ成分中にＢ成分を注入して乳化分散した後、攪拌しながら温度３０℃まで冷却して調製した。
（２）特性
得られた皮膚化粧料について諸試験を実施した結果を表２に記載する。この表から明らかなように、ビタミンＥ誘導体とユズエキスとを配合した皮膚化粧料は諸試験において良好な結果であった。それに対して比較例４，５の皮膚化粧料は、諸試験において顕著な効果は認められなかった。また，実施例の皮膚化粧料はヒト皮膚を用いた諸試験においても全く皮膚刺激は生じなかった。
【００４５】
以上記載のように、本発明が、皮膚を健やかに保つことのできる皮膚化粧料、さらに詳しく言うと、くまに対して改善効果に優れると共に、優れた肌荒れ防止効果、角質改善効果、老化防止効果及び美肌効果を発現する皮膚化粧料を提供することは明らかである。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a skin cosmetic that can keep skin healthy. More specifically, the present invention relates to a skin cosmetic that has an excellent improvement effect on bears, and further exhibits an excellent rough skin prevention effect, an exfoliating effect, an anti-aging effect, and a beautiful skin effect.
[0002]
[Prior art and problems to be solved by the invention]
In order to maintain healthy skin, it is necessary to protect the skin from various skin problems such as bears, rough skin, spots and fine lines.
[0003]
Conventionally, in order to maintain healthy skin, various plant extracts have been blended in skin cosmetics. For example, it has been clarified that a cosmetic containing a yuzu extract has an excellent protective effect and a rough skin preventing effect (Japanese Patent Publication No. 7-55888 and Japanese Patent Laid-Open No. 3-190809). However, it has not been clarified at all about the improvement effect of the bear that occupies the top among women's skin troubles. Similarly, vitamin E derivatives have been known to have high antioxidant ability, peripheral vasodilatory effect, blood circulation promoting action and other pharmacological actions, and have long been blended in pharmaceuticals, cosmetics, etc. I do not have.
[0004]
Among skin troubles, Kuma is a phenomenon that occurs mainly in the periphery of the eyelids and temporarily makes the skin appear dark. Until now, the cause of this was generally considered to be fatigue or poor circulation, but no scientific basis was shown. For this reason, the only way to deal with bears so far is to make them inconspicuous with makeup cosmetics such as foundations and concealers, and there is currently no cosmetic that fundamentally improves bears. Recently, it has been reported that blood retention in the shallow part of the skin is one of the causes of bear occurrence (Japanese Journal of Physiological Anthropology vol.4 Special Issue (1), p17-20), 44th Summary of the lectures of the Japan Society of Cosmetic Engineers Research Discussion, p49-51), the possibility that the bear could be fundamentally improved by improving this blood retention was found. However, as described above, when a yuzu extract or a vitamin E derivative is blended in the skin cosmetic alone, a sufficiently satisfactory bear improving effect has not been obtained.
[0005]
The objective of this invention is providing the skin cosmetics which can keep skin healthy. More specifically, an object of the present invention is to provide a skin cosmetic that has an excellent improvement effect on bears, and further exhibits an excellent rough skin prevention effect, an exfoliating effect, an anti-aging effect, and a beautiful skin effect.
[0006]
[Means for Solving the Problems]
As a result of intensive research in view of the above circumstances, the present inventors have found that a skin cosmetic containing a vitamin E derivative and a yuzu extract has a synergistic effect to improve bears, prevent rough skin, improve stratum corneum, and age. The present invention has been completed by confirming that each of the prevention effect and the beauty effect is expressed and the skin can be kept healthy.
[0007]
That is, claim 1 of the present invention includes α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol linoleate, dl-α-tocopherol linoleate, nicotine It is a skin cosmetic characterized by containing at least one selected from acid dl-α-tocopherol, dl-α-tocopherol ascorbate, and dl-α-tocopherol succinate and a yuzu extract. Moreover, Claim 2 of the present invention includes α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol linoleate, dl-α-tocopherol linoleate, nicotine It is a bear improving agent characterized by containing at least one selected from acid dl-α-tocopherol, dl-α-tocopherol ascorbate, and dl-α-tocopherol succinate and a yuzu extract.
[0008]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, embodiments of the present invention will be described in detail.
Examples of vitamin E derivatives used in the present invention include α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol linoleate, dl-α-tocopherol linoleate, Examples thereof include dl-α-tocopherol nicotinate, dl-α-tocopherol ascorbate, and dl-α-tocopherol succinate. These may be derived from natural products, or may be obtained by synthesis, and these may be used alone or in combination of two or more. The blending amount of the vitamin E derivative used in the present invention is preferably 0.001 to 20% by weight (hereinafter abbreviated as wt%), more preferably 0.01 to 10% by weight, based on the total amount of skin cosmetic formulation ingredients. It is.
[0009]
The yuzu extract used in the present invention can be obtained by immersing yuzu (Citrus junos Siebold) fruit in an extraction solvent, extracting it at room temperature or under heating, and filtering. Extraction solvents include water or lower alcohols such as methyl alcohol and ethyl alcohol, liquid polyhydric alcohols such as glycerin, propylene glycol, dipropylene glycol, and 1,3-butylene glycol, ethyl acetate, acetone, diethyl ether, and hexane. These organic solvents can be used alone or in combination of two or more. Preferably, water, lower alcohols, or liquid polyhydric alcohols are preferable from the viewpoint of solubility and safety of the extract.
[0010]
The obtained extract may be used as it is in the present invention, but if necessary, a product that has been decolored and deodorized by a commonly used method may be used. Further, the extract can be used after being concentrated. The blending amount of the yuzu extract used in the present invention is preferably 0.001 to 10% by weight (hereinafter abbreviated as wt%), more preferably 0.01 to 10%, based on the total amount of prescription components of the skin cosmetic and the bear improving agent. 5 wt%.
[0011]
In addition to these, the skin cosmetics and bear improving agents of the present invention include, for example, excipients and fragrances commonly used in cosmetics, fats and oils, surfactants, moisturizers, whitening agents, pH Various cosmetic ingredients such as regulators, thickeners, preservatives, antioxidants, ultraviolet absorbers, pigments, detergents, and emulsifiers can be appropriately blended in the skin cosmetics.
[0012]
The fats and oils are generally used in cosmetics, for example, liquid oils such as liquid paraffin, paraffin, cetanol, avocado oil, olive oil, jojoba oil, coconut oil; beef fat, pork fat, horse fat, turtle oil, Animal fats and oils such as mink oil, perserine oil, squalane; methylpolysiloxane, behenyl alcohol, glyceryl tricaprate, glyceryl trioctanoate and the like.
[0013]
Examples of the surfactant include anionic surfactants such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and diethanolamide lauric acid; cationic properties such as stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, and benzalkonium chloride. Surfactant: Nonionic surfactants such as glyceryl monostearate, sorbitan monostearate, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene hydrogenated castor oil, sucrose ester, fatty acid amide, etc. .
[0014]
Examples of the humectant include synthetic humectants such as glycerin, propylene glycol, 1,3-butylene glycol, sodium pyrrolidonecarboxylate, and pantethein-S sulfonate; hyaluronic acid, elastin, placenta extract, royal jelly, microbial fermentation broth Examples thereof include natural moisturizers such as chitin, chitosan, pectin, and other plant and animal extracts.
[0015]
Examples of the whitening agent include placental extract and extracts derived from other plants and animals in addition to kojic acid, ascorbic acid, arbutin and derivatives thereof.
[0016]
Examples of the pH adjuster include citric acid, sodium citrate, sodium monohydrogen phosphate, potassium dihydrogen phosphate, lactic acid, tartaric acid and other organic acids, inorganic acids and salts thereof.
[0017]
Examples of the thickener include carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, carboxyvinyl polymer, polyvinyl alcohol, tragacanth gum, sodium alginate, carrageenan, xanthan gum, bentonite and the like.
[0018]
Examples of the preservative include paraoxybenzoic acid esters such as methyl paraben, ethyl paraben, propyl paraben, and butyl paraben, phenoxyethanol, ethanol, and dehydroacetic acid.
[0019]
Examples of the antioxidant include butyloxytoluene (BHT).
[0020]
Examples of the pigment include bengara, yellow iron oxide, black iron oxide, titanium oxide, nylon powder, zinc oxide, sericite, mica, and talc.
[0021]
Examples of the cleaning agent include sodium lauryl sulfate.
[0022]
Examples of the emulsifier include soybean lecithin oil.
[0023]
Examples of the excipient include sodium sulfate.
[0024]
The form of the skin cosmetic and bear improving agent of the present invention is not particularly limited. For example, basic cosmetics such as creams, emulsions, lotions, essences, facial cleansing agents, cleansing agents, packs, lipsticks, foundations, pressed powders. It can be used as makeup cosmetics such as body soap, toiletries such as soap and soap.
[0025]
【Example】
EXAMPLES Hereinafter, although this invention is explained in full detail based on an Example and a comparative example, this invention is not limited to these. The blood volume measurement method, skin lightness measurement method, stratum corneum turnover speed measurement method (anti-aging effect), rough skin improvement effect measurement method, and sensory test method described in the Examples are as follows. The unit of the blending amount of each component in the examples and comparative examples is wt%.
[0026]
(1) Blood volume measurement method Measurement was carried out using a laser Doppler blood flow meter (Omega Flow). A contact-type variable depth probe was used for the measurement, and the measurement was performed on the lower part of the inner eye corner (depth 0.6 mm). Each measurement was performed for about 20 seconds, and the average value of about 10 seconds where the value was stable was taken as the measurement value. The blood volume before sample continuous use and after 10 days continuous use was measured, and the value obtained by subtracting the value before continuous use from the value after continuous use was defined as the blood volume difference.
[0027]
(2) Skin brightness difference measuring method L * value was measured using a color difference meter (CR-321: manufactured by Minolta). The measurement was performed 5 times for the lower part of the inner eye corner, and the average value of three points excluding the maximum and minimum values was defined as the skin brightness. The skin lightness before and after 10 days of sample use was measured, and the value obtained by subtracting the value after continuous use from the value after continuous use was defined as the skin lightness difference.
[0028]
(3) Measurement method of turnover speed of stratum corneum Ointment containing 5% by weight of fluorescent dye dansyl chloride in white petrolatum is prepared and applied to the skin of the subject's forearm for 24 hours, and dansyl chloride is applied to the stratum corneum. Osmotic bond. Thereafter, a test sample was applied to the same site twice a day (morning and evening), the fluorescence of dansyl chloride was examined every day, and the number of days until the fluorescence disappeared was defined as the turnover speed of the skin keratin. The turnover speed of the normal skin stratum corneum is 14 to 16 days. However, in the case of aging skin, the turnover speed is extended to around 18 days. On the other hand, when the antiaging effect appears, the turnover speed is shortened to around 12 days.
[0029]
(4) Measurement test method for effect of improving rough skin The effect of continuous application was examined for 20 middle-aged and older subjects having rough skin on the lower leg for 4 weeks. About 1 g of a sample was applied to the subject's left lower leg test site twice a day, and the skin condition before and after the test was determined according to the following criteria. The lower right leg was used as a control with no sample applied. The judgment results of the test site before and after the test and the control site are compared. When the skin dryness is improved by two or more levels (for example, + → −, ++ → ±) is “effective”, and when the level is improved by one level, “Slightly effective” and “invalid” when there was no change. The test result was shown by the number of subjects who became “effective” and “slightly effective”.
[0030]
(5) Sensory test method The characteristics of the sample after 20 test subjects were used for 10 days were evaluated. The evaluation was that the bear under the eye, skin brightness, gloss, smoothness, elasticity questionnaire items “the bear became thinner”, “the skin became brighter”, “the skin became brighter ”,“ Skin became smooth ”,“ Number of people who responded that the skin was stretched ”.
[0031]
Production Example 1 Production of Yuzu Extract 90 parts by weight of 50% (v / v) ethanol was added to 10 parts by weight of Yuzu fruit and extracted at 40 ° C. for 24 hours. Subsequently, this was filtered to obtain a yuzu extract used in the present invention.
[0032]
Examples 1-2 and Comparative Examples 1-3
A skin lotion was prepared by the following preparation method based on the following formulation, and the above tests were performed.
[0033]
Skin lotion (A)
Nicotinic acid dl-α-tocopherol Ethanol 10.0 (wt%) listed in Table 1
Polyoxyethylene (60) hydrogenated castor oil 1.0
Methylparaben 0.1
Fragrance 0.1
(B)
Yuzu extract Glycerin listed in Table 1 5.0
Xanthan gum 0.1
Hydroxyethyl cellulose 0.1
Purified water remaining amount [0034]
[Table 1]

[0035]
(1) Preparation method After each component A and component B were uniformly dissolved, both were mixed, dissolved, and stirred.
[0036]
(2) Characteristics The results of various tests conducted on the obtained skin lotion are also shown in Table 1. As is apparent from this table, skin lotion containing a yuzu extract and a vitamin E derivative gave good results in various tests. On the other hand, the skin lotion of Comparative Example 1 showed no significant effect in various tests. In addition, the skin lotion of the example did not cause any skin irritation in various tests using human skin.
[0037]
Examples 3-5, Comparative Examples 4-5
Based on the following formulation, a skin cosmetic was prepared by the following preparation method, and the above tests were performed.
[0038]
Example 3 Cream (A)
Dl-α-tocopherol acetate Glyceryl monostearate listed in Table 2 2.0 (wt%)
Beeswax 1.0
Sorbitan monostearate 1.0
Vaseline 4.0
Liquid paraffin 12.0
(B)
Yuzu extract N-stearoyl-L-glutamate sodium listed in Table 2 1.0
Carrageenan 0.3
Methylparaben 0.1
Purified water remaining [0039]
Example 4 Milk (A)
Dl-α-tocopherol linoleic acid listed in Table 2 Polyoxyethylene (20E.O.)
Sorbitan monooleate 0.5 (wt%)
Sorbitan sesquioleate 0.15
Cetanol 1.0
Vaseline 2.0
Squalane 5.0
Butylparaben 0.1
(B)
Yuzu extract Glycerin 10.0 listed in Table 2
Dipropylene glycol 5.0
Methylparaben 0.1
Xanthan gum 0.2
Sodium cetyl sulfate 0.3
Purified water remaining,
[0040]
Example 5 Foundation (A)
Cetanol 3.0 (wt%)
α-tocopherol Vaseline listed in Table 2 5.0
Glyceryl monostearate 2.5
Stearic acid 3.0
Butylparaben 2.0
Polyoxyethylene (10E.O.)
Stearyl ether 1.0
(B)
Yuzu extract sorbitol listed in Table 2 5.0
1,3-butylene glycol 6.0
Pigment 15.0
Sodium cetyl sulfate 1.2
Purified water remaining [0041]
Comparative Example 4 Cream (A)
Glyceryl monostearate 2.0 (wt%)
Beeswax 1.0
Sorbitan monostearate 1.0
Vaseline 4.0
Liquid paraffin 12.0
(B)
Yuzu extract N-stearoyl-L-glutamate sodium listed in Table 2 1.0
Carrageenan 0.3
Methylparaben 0.1
Purified water remaining [0042]
Comparative Example 5 Milk (A)
Sorbitan sesquioleate 0.15 (wt%)
Dl-α-tocopherol acetate Polyoxyethylene (20E.O.) listed in Table 2
Sorbitan monooleate 0.5
Cetanol 1.0
Vaseline 2.0
Squalane 5.0
Butylparaben 0.1
(B)
Glycerin 10.0
Dipropylene glycol 5.0
Methylparaben 0.1
Xanthan gum 0.2
Sodium cetyl sulfate 0.3
Purified water remaining [0043]
[Table 2]

[0044]
(1) Preparation method A component and B component in prescription were each heated to 80 degreeC, and melt | dissolved uniformly. Next, the B component was injected into the A component and emulsified and dispersed, and then cooled to 30 ° C. while stirring.
(2) Characteristics Table 2 shows the results of various tests conducted on the obtained skin cosmetics. As is clear from this table, skin cosmetics containing a vitamin E derivative and a yuzu extract were good in various tests. In contrast, the skin cosmetics of Comparative Examples 4 and 5 did not show significant effects in various tests. Further, the skin cosmetics of the examples did not cause any skin irritation in various tests using human skin.
[0045]
As described above, the present invention is a skin cosmetic that can keep the skin healthy, and more specifically, it has an excellent improvement effect on the bear, and also has an excellent skin roughening prevention effect, a keratin improvement effect, an antiaging effect. It is obvious to provide a skin cosmetic that exhibits a beautifying effect.

Claims (2)

α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol linoleate, dl-α-tocopherol linolenate, dl-α-tocopherol nicotinate, dl ascorbate A skin cosmetic comprising one or more selected from α-tocopherol and dl-α-tocopherol succinate and a yuzu extract. α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol linoleate, dl-α-tocopherol linolenate, dl-α-tocopherol nicotinate, dl ascorbate A bear improving agent comprising one or more selected from α-tocopherol and dl-α-tocopherol succinate and a yuzu extract.