JP2002363025A - Skin care preparation and method for producing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation which has high safety, controls the lowering in functions essential to the skin which are caused by external factors such as daylight exposure, dry environment, and synergistically ameliorates appearance of wrinkles, flabbiness, stain, or the like, and xerosis cutis, or the like. SOLUTION: This skin care preparation is characterized by comprising vitamin A and/or its derivative and an extract of apple seed. The skin care preparation is in the form of a solubilized preparation or emulsion preparation. The skin care preparation contains a base formulated with a high-pressure homogenizer. The method for skin care preparation production comprises preparing a mixture containing the case and the extract of apple seed with the high- pressure homogenizer and adding the to the mixture and mixing them vitamin A and/or its derivative.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin,
More specifically, the present invention relates to an external preparation for skin that has an excellent effect of improving the condition of the skin and does not excessively suppress sebum secretion. The present invention also relates to a method for producing such a skin external preparation.

[0002]

2. Description of the Related Art Various active ingredients are blended in a skin external preparation such as a cosmetic according to the purpose of use. In particular, external factors such as sun exposure and a dry environment promote the photoaging of the skin, which impairs the original function of the skin and reduces wrinkles,
It is known that it induces generation of spots and the like and drying of the skin, and a skin external preparation having an effect of suppressing these phenomena has been demanded. In response to such demands, conventionally, proteins such as collagen, elastin, and keratin derived from natural products and their hydrolysates, extracts of animals and plants,
Animal and vegetable oils, natural polysaccharides, fruit acids, and high molecular compounds have been blended. In recent years, a method has been developed in which vitamin A or a derivative thereof is blended to improve photoaging and functional deterioration of the skin. However, skin external preparations that exhibit the desired effects have not yet been developed.
There is a need for the development of active ingredients that exhibit better effects. In addition, when vitamin A or a derivative thereof is blended, these components suppress the secretion of sebum, and therefore have the disadvantage of promoting drying of the skin, and are effective in solving the above problems without decreasing the secretion of sebum. The development of ingredients is desired.

[0003]

DISCLOSURE OF THE INVENTION The present invention provides an external preparation for skin which suppresses photoaging and deterioration of skin due to external factors such as sun exposure and dry environment without inhibiting sebum secretion. The purpose is to do.

[0004]

Means for Solving the Problems In order to achieve the above object, the present inventors have conducted intensive studies and found that the combination of vitamin A and / or a derivative thereof with an apple seed extract provides safety. No problems were found, and it was found that these problems were solved, and the present invention was completed. Therefore, the present invention relates to an external preparation for skin characterized by containing vitamin A and / or a derivative thereof and an apple seed extract. One embodiment of the present invention is to use a base prepared by a high pressure homogenizer. Therefore, the present invention relates to the above-mentioned external preparation for skin containing a base prepared by a high-pressure homogenizer. The present invention also relates to the above external preparation for skin, which is in the form of a solubilized preparation or an emulsified preparation. The present invention is further directed to a method for producing an external preparation for skin, which comprises preparing a mixture containing a base and an apple seed extract with a high-pressure homogenizer, and adding and mixing vitamin A and / or a derivative thereof to the mixture. Have been.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The external preparation for skin referred to in the present specification includes, for example, emulsion, cream, lotion, cosmetic oil, pack,
Examples include cleansing, cleansing (facial cleansing foam, body shampoo, etc.), ointments, serums, gels, and hair restorers.

Examples of the vitamin A and / or a derivative thereof used in the present invention include vitamin A (alias: retinol); vitamin A fatty acid esters such as retinol acetate and retinol palmitate; and retinoic acid. The species can be used alone or in combination of two or more. Vitamin A and / or its derivatives are preferably all-trans or 13-cis, and may be a mixture thereof. Among them, vitamin A fatty acid esters are preferably used, and among them, retinol palmitate, which is relatively stable and safe, is particularly preferable. Vitamin A and its derivatives may be appropriately processed as necessary, and may have a particle size of, for example, 10%.
There are microspheres having a diameter of 1 μm to 1 mm or microspheres in which these are encapsulated. These can use a commercial item. The amount of vitamin A and / or a derivative thereof to be incorporated in the external preparation for skin of the present invention is not particularly limited, but considering effects and effects on the skin, 0.00005 to 2 mass% based on the total mass of the external preparation for skin. %
Is suitable, preferably 0.0005 to 0.5% by mass.
It is.

[0007] The apple seed extract used in the present invention comprises:
Apple Malus domestica Borkhausen (Rosaceae) (or
(Pyrus Malus) using an extraction solvent.
The preparation method is not particularly limited, but extraction is performed using various solvents under low-temperature, room-temperature, and heating conditions. Examples of the extraction solvent include water; lower monohydric alcohols such as methanol and ethanol; polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, and glycerin; and organic solvents such as acetone, ether, ethyl acetate, and n-hexane. One or more selected liquid mixtures can be used.

As a method for extracting an apple seed extract, the washed raw material is pulverized as it is or as appropriate, mixed with an extraction solvent, and then immersed for extraction. At the time of extraction, vacuum concentration, centrifugation, enzyme treatment, filtration and the like may be performed as necessary. As the apple seed extract used in the present invention, the extract obtained as described above can be used as it is depending on the extraction solvent, or can be used in an appropriately concentrated form. The residue obtained after distilling off (hereinafter referred to as pure extract) may be used. Further, as the apple seed extract, an extract obtained by diluting the extract obtained as described above with a hydrophilic solvent such as water or a lipophilic solvent can also be used. The shape of the apple seed extract may be any of powder, liquid, and semi-solid, and may be oily or aqueous. A commercially available product may be used as the apple seed extract. As a specific example of a commercially available product, the pure extract as described above is diluted with a cosmetic solvent such as ethanol, 1,3-butylene glycol, purified water or a mixture thereof, and hexyldecanol.
A so-called dissolved apple seed extract is known, and includes, for example, Ederline (manufactured by SEPORGA).

[0009] One example of an operation for obtaining an apple seed extract is as follows: apples are squeezed, and the residue is collected and washed. After the seeds are collected, the seeds are pulverized and extracted with an ethanol solvent. Then the solvent is distilled off (evaporated)
And the residue is dissolved in a cosmetic solvent. After filtration, the mixture is heated at 65 ° C. for 12 hours and cooled to room temperature to obtain an apple seed extract. The amount of the apple seed extract to be incorporated into the skin external preparation of the present invention is 0.00 as a residue (extract of the extract) excluding the extraction solvent, based on the total mass of the skin external preparation.
The range of 001 to 1.5% by mass is appropriate. Within such a range, a synergistic effect with vitamin A and its derivatives can be obtained without any problem. When the pure extract is diluted and dissolved in a suitable solvent and blended into a skin external preparation, the amount is generally 0.01% based on the total weight of the skin external preparation.
-30% by mass, more preferably 0.05%
-10% by mass.

The external preparation for skin of the present invention may be used in ordinary cosmetics or quasi-drugs in addition to the above-mentioned essential components, depending on the form of the target external skin preparation, as long as the effects of the present invention are not impaired. Other components, such as fats and oils, waxes, hydrocarbons, fatty acids, higher alcohols, esters, surfactants, plant and animal extracts, humectants, alcohols, thickeners, drugs, ultraviolet absorbers, UV scattering agents, pigments, coloring agents,
Preservatives, antioxidants, flavoring agents, chelating agents and the like can be added as necessary. The method for preparing the external preparation for skin of the present invention is not particularly limited, and it can be prepared according to an ordinary method.

The external preparation for skin of the present invention is used as a solubilized preparation such as a lotion or an emulsified preparation such as a cream or an emulsion. By using, a unique organoleptic property, specifically, a smooth and excellent application feeling can be obtained, and the effect of the external preparation for skin of the present invention can be further enhanced. When a high-pressure homogenizer is used, at least one selected from solubilizers or emulsifiers such as nonionic surfactants, lecithin (phospholipid) obtained from soybean or egg yolk and derivatives thereof (mainly lyso-forms) as a base component is used. At least one polyhydric alcohol selected from glycerin, 1,3-butanediol, propylene glycol, dipropylene glycol, polyethylene glycol, isoprene glycol, 1,2-pentanediol, etc .; ester oil, silicon and the like At least one oil selected from derivatives, animal and vegetable oils, higher fatty acids, higher alcohols, mineral oils, and the like; and water.

The solubilizer or emulsifier used in the preparation is not particularly limited, and examples thereof include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester,
Polyoxyethylene glycerin fatty acid ester, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene sorbite fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene block polymer, polyoxyethylene polyoxypropylene alkyl ether, sucrose Examples include fatty acid esters, maltitol fatty acid esters, alkyl glucosides, egg yolk lecithin, soybean lecithin, egg yolk lysolecithin, soybean lysolecithin, hydroxylated soybean lecithin and hydrogenated products thereof. One or a combination of two or more of these can be used as a solubilizer or emulsifier.

In the case of a solubilized preparation, a pre-mixed liquid obtained by uniformly mixing a solubilizer, a polyhydric alcohol, water and an oil is
A base is obtained by treatment with a high-pressure homogenizer. In the case of an emulsified preparation, a base can be obtained by uniformly mixing an emulsifier, a polyhydric alcohol and an oil to form an oil phase, adding water thereto, and treating the pre-emulsion with a high-pressure homogenizer. Preparation of the pre-mixed liquid or the pre-emulsion can be carried out by an ordinary method using a normal pressure type homogenizer. In these preparations, heating or heat treatment can be appropriately performed as necessary.

When preparing a base using a high-pressure homogenizer, the mass ratio of the solubilizer or emulsifier, polyhydric alcohol, oil, and water is determined based on the total amount of the premixed liquid / preliminary emulsion. If so, generally solubilizers: 15-
45% by mass, polyhydric alcohol: 10 to 50% by mass, oil: 1 to 15% by mass, water: 10 to 50% by mass. In the case of an emulsified preparation, generally, an emulsifier: 0.2 to 4% by mass. , Polyhydric alcohol: 2 to 30% by mass, oil content: 5 to 40
% By mass, water: 20 to 80% by mass. The base obtained by the high-pressure homogenizer can be used as it is as the base of the external preparation for skin of the present invention, or the base can be mixed with a suitable base to prepare the base of the external preparation for skin of the present invention. Is also good. As long as the decomposition of the components by heat does not occur, the apple seed extract and optionally other additives may be added during the preparation of the premix or the pre-emulsion or when using a high-pressure homogenizer. .

As specific examples of the high-pressure homogenizer to be used, Gaulin homogenizer APV (manufactured by Runny), Nanomizer (manufactured by Nanomizer), microfluidizer (manufactured by Microfluidex, Mizuho Industries, Ltd.)
And an optimizer (manufactured by Sugino Machine Co., Ltd.), among which a microfluidizer is preferable. The microfluidizer is disclosed in U.S. Pat. No. 4,533,254, and is a continuous ultra-high pressure homogenizer, which can regulate the pressure up to 200 to 3000 kgf / cm ² depending on the model. When using a high-pressure homogenizer, select an appropriate pressure from the range in which the pressure can be adjusted, for example, 1000 to 1500 kgf /
In cm ² , the number of passes can be appropriately selected and operated from 1 to 5 times.

Since the mixture prepared using the high-pressure homogenizer has a relatively high temperature immediately after preparation, it is preferable to add vitamin A and / or a derivative thereof after sufficiently cooling the mixture to room temperature or lower. Further, if necessary, other components are added and uniformly mixed to obtain a skin external preparation of the present invention. The apple seed extract may be added together with vitamin A and / or a derivative thereof. The external preparation for skin of the present invention can be used by a usual use method according to the form.

[0017]

Next, the present invention will be described specifically with reference to examples and comparative examples. The present invention is not limited by these.

Example 1 and Comparative Examples 1-4 The creams of Example 1 and Comparative Examples 1-4 were prepared with the compositions shown in Table 1 (unit:% by mass, total amount: 100% by mass).

[0018]

[Table 1] ^{* 1} : The compounding amount is the amount as the pure extract. ^{* 2} : Apple: Extract from 1,3-butylene glycol solution from the fruit (raw) of Malus domestica Borkhause (Rosaceae). The compounding amount is an amount as a pure extract.

Preparation of cream [11] (11) and (12) are dissolved in a part of the component (15).
A solution of (13) is added to a part of (15) and mixed. Next, a solution obtained by dissolving (10) and (14) was added to the mixture of (6) and (7) to make the mixture uniform, and further (1) to (5),
The mixture of (8), (9) and the remaining (15) was added and stirred uniformly to obtain the creams of Example 1 and Comparative Examples 1 to 4.

<Use Test 1: Degree of Skin Improvement> Example 1 above
The creams of Comparative Examples 1 to 4 were used by 10 healthy female panels (28 to 45 years old). Use the cream of Example 1 on the right face and the cream of Comparative Example 1 on the left face.
It was applied twice a day (morning and evening), and after one month of continuous use, the effect after use was evaluated by self-report of 10 persons as compared to before use (test). Then, the left face was sequentially compared with Comparative Examples 2, 3, and 4.
The same test was performed by replacing each of the creams (test,...). Evaluation items are a) the effect of giving the skin firmness,
The evaluation was performed according to the following criteria, as b) the effect of improving wrinkles, and c) the effect of moisturizing the skin. A: There was considerable effect. B: There was some effect. C: No change. D: It got worse. Table 2 summarizes the number of persons in each of the judgments A to D.

[0021]

[Table 2] Improvement of skin

The average evaluation of the cream of Example 1 in the above tests is as follows. As is clear from the results in Table 2, it can be seen that the cream of Example 1 according to the present invention has an excellent skin condition improving effect as compared with those of Comparative Examples 1 to 4.

<Use Test 2: Sebum Amount> The creams of Example 1 and Comparative Examples 1 to 4 were treated with 10 healthy female panels (28
~ 45 years old). For use, apply the cream of any of Example 1 and Comparative Examples 1 to 4 twice a day (morning and evening) to the forehead, and after one month of continuous use, measure the amount of sebum on the forehead after use. And the amount of sebum in the forehead before use. The measurement of the amount of sebum was performed by gently wiping the forehead, which was the test site, with a 70% aqueous ethanol solution before measurement, and 30 minutes later, the amount of sebum on the forehead (μg / c
m ² ) was measured with an oil content meter (Sebumeter SM810). The results are summarized in Tables 3-4.

[0024]

[Table 3] Sebum amount in forehead (μg / cm ² ) The lower numerical value after use indicates the difference from before use.

[0025]

[Table 4] Sebum amount in forehead (μg / cm ² ) The lower numerical value after use indicates the difference from before use.

As is clear from the results in Tables 3 and 4,
It can be seen that the cream of Example 1 according to the present invention suppresses a decrease in the amount of sebum due to the vitamin A derivative.

The skin external preparations of Examples 2 to 11 are shown below. Each composition is 100% by mass in total. Example 2 Lotion mass% (1) Retinoic acid 0.005 (2) Apple seed extract (aqueous, pure extract 3%) 3.0 (3) Polyoxyethylene (40) hydrogenated castor oil 0.2 ( 4) polyoxyethylene (20) polyoxypropylene (4) 0.1 cetyl ether (5) polyethylene glycol 1000 2.0 (6) 1,2-pentanediol 1.0 (7) propylene glycol 1.5 (8 ) Ethanol 3.0 (9) Methyl paraben 0.1 (10) Natural vitamin E 0.05 (11) Hydroxypropyl methylcellulose 0.12 (12) Citric acid (10% aqueous solution) 0.1 (13) Sodium citrate ( (10% aqueous solution) 0.6 (14) Purified water Remainder <Production method> (11) was added to (14) and dissolved, and (3)
(10) and (12) and (13) are added. Finally, (1) and (2) were added and mixed, and this was filtered to obtain a lotion. This lotion was excellent in improving skin condition without suppressing sebum secretion.

Example 3 Emulsion Mass% (1) Retinol palmitate 0.5 (microsphere product: average particle size 35 μm) (2) Apple seed extract (oily, pure extract 3%) 10.0 (3 ) Tri (caprylic / capric acid) glycerin 1.0 (4) Octyldodecyl myristate 1.0 (5) Squalane 0.5 (6) Glycerin 3.5 (7) Dipropylene glycol 1.5 (8) Methyl paraben 0 1 (9) Ethylparaben 0.05 (10) Propylparaben 0.05 (11) Phenoxyethanol 0.3 (12) Tocopherol acetate 0.1 (13) Hydrogenated soybean phospholipid 0.4 (14) Carboxyvinyl polymer (1% aqueous solution) 10.0 (15) L-arginine (10% aqueous solution) 0.7 (16) Purified water Remaining <Production method> (2) to (13) were mixed at 80 ° C, and then mixed with 80 ° C.
(16) is gradually added. This solution was homogenized at 5000 rpm for 3 minutes using a homomixer,
Subsequently, high-pressure emulsification treatment was performed using a microfluidizer (1200 kgf / cm ² , two passes). After high-pressure emulsification, the mixture was added to (14) to make it homogeneous, and then (15) was added and mixed, cooled to around 30 ° C, and finally (1) was added to obtain an emulsion. This emulsion was excellent in use feeling and excellent in improving skin condition without suppressing sebum secretion.

Example 4 Cream mass% (1) retinol palmitate 0.5 (2) apple seed extract (oily, extractables 3% pure) 5.0 (3) glyceryl tri-2-ethylhexanoate 2.0 (4) Cetyl 2-ethylhexanoate 2.0 (5) Vaseline 0.5 (6) Liquid paraffin 7.0 (7) Lipophilic glyceryl monostearate 0.5 (8) Polyglycerin fatty acid ester 3.5 (9) 1,3-butylene glycol 6.0 (10) Methyl paraben 0.2 (11) Phenoxyethanol 0.5 (12) Tocopherol acetate 0.1 (13) Stearic acid 0.3 (14) Carboxyvinyl polymer (1 % Aqueous solution) 30.0 (15) Potassium hydroxide (10% aqueous solution) 1.0 (16) Purified water Remaining <Production method> (2) to (13) were mixed at 80 ° C, and then mixed with 80 ° C.
(16) is gradually added. After adding (14) heated to 80 ° C., add (15), mix, and cool to around 30 ° C. Finally, (1) was added to obtain a cream. This cream was excellent in improving skin condition without suppressing sebum secretion.

Example 5 Cosmetic Gel Mass% (1) Retinol acetate 0.0005 (2) Apple seed extract (oily, pure extract 3%) 0.01 (3) Dimethicone (10CS) 3.0 (4) Polyoxyethylene / methylpolysiloxane copolymer 1.5 (5) 1,3-butylene glycol 2.5 (6) Glycerin 2.5 (7) Sorbit liquid 1.5 (8) Ethanol 2.0 (9) Methylparaben 0.2 (10) Tocopherol acetate 0.05 (11) Xanthan gum 0.12 (12) Carboxyvinyl polymer 0.4 (13) Sodium hydroxide (10% aqueous solution) 1.0 (14) Purified water balance <Preparation method > (3) to (5) were mixed and (12) was added to (1)
Add the solution dissolved in 4) and further add (13) to make it uniform. Next, the mixed liquid of (6) to (11) was added, and finally (1) and (2) were added to obtain a cosmetic gel. This cosmetic gel was excellent in improving skin condition without suppressing sebum secretion.

Example 6 Serum mass% (1) Retinol palmitate 2.0 (2) Apple seed extract (aqueous, pure extract 3%) 3.0 (3) Olive oil 0.2 (4) Poly Oxyethylene (60) hydrogenated castor oil 2.0 (5) Maltitol 0.5 (6) Glycerin 2.5 (7) Trehalose 1.5 (8) Ethanol 3.0 (9) Methyl paraben 0.2 (10) Magnesium phosphate ascorbyl 0.5 (11) Xanthan gum (1% aqueous solution) 5.0 (12) Hydroxyethyl cellulose (1% aqueous solution) 15.0 (13) Trimethylglycine 1.0 (14) Purified water Remaining <Preparation method> ( 3) to (9) are mixed, (14) is added to the mixture to make it uniform, and then (10) to (13) are further added to make it uniform. Next, (1) and (2) were added to obtain a serum. The essence of the present invention was excellent in improving skin condition without suppressing sebum secretion.

Example 7 Facial Wash Foam Mass% (1) Retinol acetate 0.00005 (2) Apple seed extract (oily, pure extract 3%) 0.05 (3) Sodium acylglutamate 22.0 (4) Tetra Decenesulfonic acid sodium 5.0 (5) 1,3-butylene glycol 10.0 (6) glycerin 5.0 (7) lauric acid diethanolamide 3.0 (8) polyethylene glycol 1500 5.0 (9) methyl paraben 0 2 (10) Tocopherol acetate 0.05 (11) Polyethylene glycol monostearate 4.0 (12) Dipotassium glycyrrhizinate 0.1 (13) Allantoin 0.1 (14) Purified water Residue <Production method> At 80 ° C (3) to (13) are mixed, and the mixture is heated to 80 ° C.
(14) is gradually added and mixed. After cooling to around 30 ° C. and adding (1) and (2) to make it uniform, the foam was defoamed to obtain a face-wash foam. This face-wash form
It was excellent in improving skin condition without suppressing sebum secretion.

Example 8 Pack Mass% (1) Retinol acetate 0.05 (2) Apple seed extract (oily, extract pure 3%) 0.5 (3) Polyvinyl alcohol 8.0 (4) Polyethylene glycol 1500 1.5 (5) Propylene glycol 5.5 (6) Methyl paraben 0.1 (7) Polyoxyethylene (60) hydrogenated castor oil 0.5 (8) Tocopherol acetate 0.05 (9) Ethanol 8.5 ( 10) Disodium edetate 0.05 (11) Fragrance 0.03 (12) Purified water Remaining <Production method> Mix (4) to (8), and add (3) to (1)
Add the heat-dissolved solution to 2), and further add (9) and (11)
To make it uniform. Next, (1) and (2) were added to obtain a pack. The above pack was excellent in the effect of improving the skin condition without suppressing sebum secretion.

Example 9 Cleansing Mass% (1) Retinol palmitate 0.0005 (2) Apple seed extract (oily, pure extract 3%) 0.8 (3) Polyoxyethylene (20) cetyl ether 5 (4) Polyoxyethylene (7) Glyceryl coconut oil fatty acid 1.5 (5) 1,3-butylene glycol 5.0 (6) Glycerin 3.0 (7) Phenoxyethanol 0.5 (8) Ethanol 2.0 (9) Methyl paraben 0.2 (10) Dibutylhydroxytoluene 0.05 (11) Xanthan gum (1% aqueous solution) 10.0 (12) Carboxyvinyl polymer (1% aqueous solution) 50.0 (13) Potassium hydroxide (10 % Aqueous solution) 1.5 (14) Remaining purified water <Preparation method> (3) to (10) are mixed, and (12) and (13) are added thereto to make them uniform. Further, (11) and (14) were added to make uniform, and finally (1) and (2) were added to obtain cleansing. This cleansing was excellent in improving skin condition without suppressing sebum secretion.

Example 10 Hair restorer mass% (1) Retinol palmitate 0.05 (2) Apple seed extract (oily, pure extract 3%) 0.1 (3) Egg yolk lysophosphatidylcholine 0.5 (4) β-glycyrrhetinic acid 0.1 (5) D-pantothenyl alcohol 0.5 (6) glycerin 2.5 (7) 1,3-butylene glycol 1.5 (8) ethanol 35.0 (9) methyl paraben 2 (10) Tocopherol acetate 0.1 (11) Polyoxyethylene (40) hydrogenated castor oil 0.1 (12) Purified water Remaining <Production method> Mix (1) to (4), (6) and (7) And
Add (12) gradually to this. This solution was appropriately subjected to high-pressure emulsification treatment, and a solution obtained by dissolving (9) to (11) in (8) to this high-pressure emulsification treatment solution was added to obtain a hair restorer as uniform. This hair restorer was excellent in use feel and excellent in improving the scalp condition without inhibiting sebum secretion.

Example 11 Cosmetic oil mass% (1) Retinol palmitate 0.1 (2) Apple seed extract (oily, pure extract 3%) 30.0 (3) Natural vitamin E 0.1 (4) Macadamia nut oil 1.0 (5) Bacyl alcohol 0.3 (6) Octyl dodecanol remainder <Production method> (1) to (6) were uniformly mixed to obtain a cosmetic oil.
This cosmetic oil was excellent in use feeling and excellent in improving skin condition without inhibiting sebum secretion.

[0037]

The external preparation for skin of the present invention, while containing vitamin A and / or a derivative thereof, suppresses an excessive decrease in the amount of sebum, and is caused by external factors such as sun exposure and a dry environment. It is an external preparation for skin that suppresses the original deterioration of the function, synergistically improves the occurrence of wrinkles, blemishes, spots, etc. and skin dryness, and also takes safety into consideration.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/06 A61K 7/06 7/48 7/48 7/50 7/50 31/07 31/07 31 / 23 31/23 35/78 35/78 HF terms (reference) 4C083 AA111 AA112 AA122 AB032 AB052 AC012 AC022 AC072 AC102 AC112 AC122 AC132 AC152 AC172 AC182 AC242 AC302 AC352 AC392 AC422 AC432 AC482 AC532 AC582 AC642 AC682 AC792 AD042 AD092 AD112 AD152 AD162 AD212 AD282 AD352 AD532 AD572 AD621 AD622 AD662 BB01 CC03 CC04 CC05 CC06 CC07 CC37 DD31 DD38 FF05 4C088 AB51 AC04 BA08 BA37 CA03 MA03 MA17 MA22 MA63 NA14 ZA89 ZA92 ZC23 4C206 AA01 AA02 CA10 DA12 DB04 DB06 DB51 KA01 MA02 MA04 MA04 MA04

Claims (5)

[Claims] 1. An external preparation for skin comprising vitamin A and / or a derivative thereof and an apple seed extract. 2. The external preparation for skin according to claim 1, wherein the vitamin A derivative is a vitamin A fatty acid ester. 3. It is in the form of a solubilized preparation or an emulsified preparation,
An external preparation for skin according to claim 1 or 2. 4. The external preparation for skin according to claim 1, which comprises a base prepared by a high-pressure homogenizer. 5. A method for producing an external preparation for skin, comprising preparing a mixture containing a base and an apple seed extract using a high-pressure homogenizer, and adding and mixing vitamin A and / or a derivative thereof to the mixture.