CN110448495A - A kind of cosmetic composition with collaboration antioxidant effect - Google Patents
A kind of cosmetic composition with collaboration antioxidant effect Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a kind of cosmetic compositions with collaboration antioxidant effect.By weight percentage, the raw material components which includes have: Mi Luomu leaf/stem extraction 0.1-6%, hydrolysis Sodium Hyaluronate 0.01-0.8%, tocopherol 0.01-0.6%, palmityl tea extraction 0.01-0.6%, cosmetic matrix 92-99.87%.The present invention has selected the effective cosmetic materials of a variety of collaborations, has taken into account preventative anti-oxidant, and the effect of eliminate the oxygen radical generated, can achieve safe and efficient collaboration antioxidant effect.
Description
Technical field
The present invention relates to a kind of skin-protection products, belong to Cosmetic Manufacture technical field, have collaboration more particularly to one kind
Cosmetic composition of antioxidant effect and preparation method thereof.
Background technique
We live in the air rich in oxygen, are that oxygen gives us life, but oxygen can also kill us
Healthy cell.Certainly, directly kill cell is not oxygen itself, but cries having for oxygen radical by a kind of its of generation
Evil substance.
Free radical is called free radical, it is the band of the homolysis (Homdytic Fission) by simple substance or compound and generation
There are the atom or group of unpaired electron.Its single electron has strong pairing tendency, it is intended to former with other in various ways
Subbase group combines, and forms more stable structure, thus free radical is very active, becomes the reactive intermediate of many reactions.
The intracorporal free radical of people is divided into oxygen radical and non-oxygen radical.Oxygen radical is occupied an leading position, and freedom is accounted about
The 95% of base total amount.Oxygen radical includes superoxide anion (O2 -), hydrogen peroxide molecule (H2O2), hydroxy radical (OH),
Hydroperoxy (HO2 -), alkane peroxy (ROO), alkoxy (RO), NO free radical (NO), peroxynitrite
(ONOO-), hydroperoxides (ROOH) and singlet oxygen (1O2) etc., they are referred to as active oxygen (reactive oxygen again
Species, ROS), it is all free radical mostly important in human body.Non- oxygen radical mainly have hydroperoxyl radical (H) and it is organic from
By base (R) etc..
Mainly there are three aspects for damage of the free radical to human body:
1, it is destroyed cell membrane；
2, serum antiprotease is made to lose activity；
3, lesioned gene leads to the appearance and accumulation of cytometaplasia.
Free radical is that cell membrane starts first to the attack of human body.Cell membrane is rich in elasticity and flexibility, this is by it
What loose chemical structure determined, Just because of this, its electronics is easily lost, therefore cell membrane is easily by free radical
Attack.Once seizing electronics by free radical, cell membrane will follow the string and lose all functions, so as to cause painstaking effort system disease
Disease.More seriously attack of the free radical to gene can be such that the molecular structure of gene is destroyed, lead to gene mutation, from
And cause the confusion of entire life generating system.
It is injured caused by free radical attack cells such as:
1) lipid oxide: if lipid is oxidized on cell membrane, cell membrane circulation can be made to sexually revise, nutrient cannot be introduced into cell
Inside cause meronecrosis.If the speed that cell membrane is destroyed is greater than the speed of cytothesis, the function of histoorgan will be by
Aging is generated to influence.
2) albumen is attacked, enables albumen lose function, or form macromolecular, is even broken, causes lesion.Occur it is subcutaneous it
Collagen tissue can enable skin follows the string, muscles and bones is stiff etc..
3) destruction of the free radical to DNA mainly causes DNA strands of cutting or the modification of base.Once DNA is cut
Disconnected, human body may generate mutation because of can not normally repair during repairing.It can derive after free radical attack base
Some byproducts, these byproducts can make heredity that mistake occur and have carcinogenic possibility.If human body for a long time by such injury,
Caused result is exactly various chronic diseases generations and the aging of people.
Currently, there are some one-sidedness more in oxidation resistant cosmetics:
1) be much using the single substance with reproducibility, but its specific inoxidizability on earth how, do not have
Actual test is not comprehensive enough；
2) some be using a variety of reducing substances, but or be no concertedness, only simply combine or be
Concertedness is experiments have shown that deficiency；
3) there are stability problem, discoloration problems for antioxidation cosmetic product；
4) in antioxidation cosmetic product the dosage of antioxidant be not it is The more the better, some substances can play instead after adding
Negative effect；
5) many antioxidation cosmetic product do not consider that skin environment has water also to have lipid, and the selection of antioxidant also needs
Consider the balance of grease phase partitioning.
Therefore, at present for, develop it is a kind of really antioxidant composition with synergy be necessary.
Summary of the invention
In order to overcome the shortcomings and deficiencies of existing antioxidation cosmetic product, the object of the present invention is to provide one kind to have collaboration anti-
The cosmetic composition of oxidation effectiveness, the composition with collaboration antioxidant effect provided by the invention have also been taken into account preventative anti-
Oxidation, and eliminate the oxygen radical generated.
To solve the above-mentioned problems, the present invention is achieved by technical solution below.
A kind of cosmetic composition with collaboration antioxidant effect includes by weight percentage raw material group below
Point:
Furthermore, it is described have collaboration antioxidant effect cosmetic composition, by weight percentage, comprising with
Under raw material components:
Furthermore, the present invention has the cosmetic composition of collaboration antioxidant effect, the cosmetic matrix
Include moisturizer, chelating agent, emollient, skin conditioning agent, emulsifier, solubilizer, essence, preservative, thickener, skin sense tune
One of agent, solvent, water are a variety of.
Furthermore, the cosmetic composition with collaboration antioxidant effect is made by following processing step:
1) oil is added in oily phase pot, is stirred and heated to 80 DEG C, dissolution is complete；
2) water phase is added in water phase pot, is stirred and heated to 80 DEG C, dissolution is complete；
3) water phase and oil are mutually pumped into emulsion pot, emulsifying 6-8 minutes, stabilizer is added in emulsion pot and continues cream
Change 5-8 minutes, adjust PH, keeps the temperature 20 minutes；
4) 37 DEG C are cooled to, remaining skin conditioning agent, preservative, aromatic is added, is stirred 30 minutes, sample detection is closed
It discharges after lattice.
Furthermore, by weight percentage, the cosmetic matrix is made of raw material components below:
Furthermore, the solvent is selected from water, glycerol, butanediol, 1,3-PD, dipropylene glycol, polyglyceryl ether -26
One of or their mixture；
Furthermore, the emulsifier is selected from amino acids, sucrose ester, glyceride type, polyglycereol esters, sapn
Class, Tweens, polyethylene glycols one or more；
The moisturizing grease is selected from silicone oil, vegetable fat, other Synthetic Oils etc.；
The stabilizer is selected from carbomer, biogum class, esters of acrylic acid and its modifier, cellulose family；
The PH regulator is selected from arginine, triethanolamine, inorganic base；
The skin conditioning agent is selected from each Plant Extracts, tunning, peptides, inorganic matter etc.；
The preservative is selected from parabens, glycols, benzoic acids, Phenoxyethanol, sorb acids etc..
Furthermore, the present invention has the cosmetic composition of collaboration antioxidant effect, can be used for various cosmetics agent
Type, including but not limited to surfactant, facial treatment essence, skin care mile, facial treatment milk, skin care cream, color make-up, face cleaning.
Primary raw material source of the invention and effect are described as follows:
1. close Luo Muye/stem extraction
From the special algae of close Luo Mu or certain.
Close Luo Mu can survive in prolonged drought environment, also in that its own is with the presence of some special substances, example
Such as some small molecule solutes, such as the enantiomter of glycosylglycerol etc..When close Luo Mu face in arid season it is nearly all
When the pressure that the water flow in cell is lost.Its inner material is protected cell membrane and eucaryotic cell structure invariance, is not damaged, and also has excellent
Water lock ability.
During cell membrane dehydration, since some particular matters in close Luo Muye/stem extraction reduce cell membrane
Ess-strain, i.e. cell membrane, which become gelatinous trend, to be reduced.Here it is a kind of protections to cell membrane, make film in the feelings of low hydration
Mobility is still kept under condition.
There is experiment to confirm that skin moisture-keeping, elasticity, smoothness can be improved in close Luo Muye/stem extraction；Skin can also be increased
Skin thickness reduces rubefaction；It can be with the synthesis of Type I collagen amyloid protein precursor in accelerated ageing cell, to delay senescence；It can be with
The amount of SOD1 in aged cells is improved, to reach its oxidation resistant effect.
Luo Muye/stem extraction can also increase the ATP of aged cells, enhance cell viability.It can also promote wound
Healing and tissue repair.He does not illustrate how to remove the free radical generated.It protects cell membrane injury-free, improves SOD1's
Amount improves body intrinsic antioxidative ability.
2. hydrolyzing Sodium Hyaluronate
The hydrolysis Sodium Hyaluronate that the present invention selects is that molecular weight is obtained less than 5KDa using unique digestion technique,
With superelevation bioactivity, energy quick penetration epidermis reaches skin corium, can remove the free radical generated.It can also drop
Low inflammatory factor activity, inhibits inflammatory reaction, repairs damaged cell, fight scytitis caused by various stimulations and sensitivity.He
Do not illustrate how prevention free radical, it is also different without the anti-oxidation method inside and outside display mould, it can be clear to deep layer with skin surface
Except the free radical generated, pass through auto-degradation.
3. tocopherol
The tocopherol that the present invention selects is D-delta tocopherol, is to separate, be concentrated from vegetable oil, purifying obtained height
Content product is a kind of anti-oxidant protective agent of efficiency natural.
Vitamin E group shares eight kinds of isomers: four kinds of tocopherols and four kinds of tocotrienols；Tocopherol include α, β,
Tetra- kinds of γ, δ, and δ (delta) tocopherol is that wherein most stable and oxidation resistance is strongest.
D-delta tocopherol has stronger anti-oxidation protection to act on grease.In the AOM oxidation test and 120 to lard
DEG C oxidation induction experiment show: D-delta tocopherol compared with alpha tocopherol (Ve) oxidation resistance raising 40-50%.
D-delta tocopherol has good self stability.(examination is decomposed in the thermostabilization to tri- kinds of tocopherols of α, γ, δ
Test) test display: 10 times high compared with α type of D-delta tocopherol thermal stability or more, 3 times high compared with γ type or more, thus in product
Using above can be used for high temperature adding technology.
D-delta tocopherol has good anti-oxidation protection to act on a variety of active ingredients, such as some active whitening compositions, face
Color, etc..Anti-oxidation protection (grease, color) to lipstick is very outstanding.
D-delta tocopherol has good photooxidation protective effect to a variety of greases.Primarily focus on the anti-of lipid
Oxidation protection.Protect the lipid of the grease and skin itself in cosmetics not oxidized.Pay attention to generate when excess and help
Oxidation effectiveness.
4. palmityl tea extraction
The palmityl tea extraction that the present invention selects is the active components of plants extracted by esterification green tea polyphenol.
It is well known that tea polyphenols have very strong oxidation resistance, peroxidatic reaction of lipid can be blocked, scavenging capacity enzyme
Effect.The higher kind containing tea polyphenols in green tea teas.Unleavened green tea is rich in active polyphenol ingredient, catechin
Content superelevation.
But tea polyphenols are to belong to water-soluble substances, and water-soluble substances hardly enter biomembrane.Therefore, in film
Free radical influence it is smaller.
By above-mentioned technical proposal, the invention has the advantages that and advantageous effects:
1) close Luo Muye/stem extraction in composition of the invention can protect cell membrane and preserve from, and also can be improved
Body intrinsic antioxidative ability (endogenous) belongs to prevention property.D-delta tocopherol has a variety of greases and skin lipid
Good photooxidation protective effect (external source)；It is clear that hydrolysis Sodium Hyaluronate is that hydrophilic small-molecule substance can also go deep into skin
Except free radical；Palmityl tea extraction belongs to lipophilic, can also go deep into skin inner layer and remove free radical；Such a each machine
The mutually matched combination of line of reasoning diameter, can be many by the raising of antioxidant levels synergy.
2) selected species of the present invention are provided with very strong lipophilicity after over-churning, can go deep into skin, reach protection flesh
Skin is not influenced by oxidative stress effect, and skin protein and lipid is protected not to be destroyed by free radical, by reinforcing capillary
Wall improves the microcirculqtory system of skin, inhibits saccharification；In system after esterification for body fluid cell etc. based on water base
Anti-oxidant do not indicate method；After esterification, there is lipophilicity, skin can be goed deep into and remove free radical from the inside to surface.
3) it is provided by the invention have collaboration antioxidant effect composition, also taken into account it is preventative anti-oxidant, and eliminate
The oxygen radical generated.The anti-oxidation efficacy compared to single material component, the effect of composition are confirmed by various experiments
It significantly improves.
Specific embodiment
Below by way of specific preferred embodiment combination effete test embodiment, invention is further described in detail, but the present invention
It is not limited in embodiment below.
The invention discloses a kind of cosmetic compositions with collaboration antioxidant effect.By weight percentage, the change
The raw material components that cosmetic compositions include have: Mi Luomu leaf/stem extraction 0.1-6%, hydrolysis Sodium Hyaluronate 0.01-0.8%,
Tocopherol 0.01-0.6%, palmityl tea extraction 0.01-0.6%, cosmetic matrix 92-99.87%.The present invention selects
A variety of effective cosmetic materials of collaboration can achieve safe and efficient collaboration antioxidant effect.
Following table 1 show the cosmetic composition with collaboration antioxidant effect of embodiment 1-5, is fabricated to skin care milk
Liquid, raw material components proportion are as shown in table 1.Of the invention has the composition of collaboration antioxidant effect in other State of cosmetics
It is not listed in the performance of (such as Essence, cream, toner dosage form).
The facial treatment milk of 1 1-5 of the embodiment of the present invention of table and the component formula (weight percentage %) of reference examples
Note: the emulsifier in above-mentioned table 1 selects stearoyl-glutamic acid sodium, stearine；Thickener selects xanthan gum；
Preservative select methylparaben, propylben, Phenoxyethanol mixture.
Above-described embodiment 1-5 has the preparation method of the cosmetic composition of collaboration antioxidant effect, comprising the following steps:
1) A is added in water phase pot, stirring is warming up to 85 DEG C, and homogeneous stirs evenly；
2) B is added to oily phase pot, stirring melts complete；
3) A, B are added to emulsifying 8 minutes in emulsion pot, insulated and stirred 20 minutes；
4) emulsion pot stirring is cooled to 37 DEG C, C phase is added, stirs evenly.
5) after detection is qualified, discharging.
The following are the contents of effete test embodiment.
Because there is water in human skin and cellular environment, and have lipid, therefore, the selection of composition need to consider water phase and
Oily phase partitioning, free radical are related to superficial skin and deep skin, therefore also to consider the osmosis of active constituent, also to pass through
Its oxidation resistance is strictly tested, dosage is not The more the better, nor simple inference obtains, it is to be obtained by much testing
, also material combination or its stability for being applicable in cosmetics are tested.
Effete test embodiment 1
This experimental example is by the anti-oxidant combination of test sample in vitro to the clearance rate of DPPH. free radical, and to UVB spoke
The influence of cell viability and lipid peroxide (LPO) content according to the HaCaT cell of modeling, to evaluate the anti-oxidant of sample
Effect.
1 test material and instrument
1.1 test cell strains
People immortalizes epidermal cell (HaCaT), is purchased from Shanghai Cell Bank of the Chinese Academy of Sciences.
1.2 test reagent
DPPH, Sigma company；DMSO, Thermo Fisher company；Pancreatin cell activity (MTT) kit,
BioAssay Syytems company；LPO kit, Ya Ji biotech firm.
1.3 test specimen
Embodiment 1-5, reference examples.
1.4 test apparatus
J124BC type electronic analytical balance (Changshu Shuan Jie test equipment factory)；SW-CJ superclean bench (Thermo
Fisher Scientific)；SS-01 type UVB ultraviolet phototherapy instrument, sigma company；SynorgyHT microplate reader (the U.S.
BioTek company).
2 test methods
2.1 DPPH. radicals scavengings
2.2 cell recovery
2.3 cell culture
2.4 UVB irradiation
2.5 mtt assay detect cell Proliferation vigor
The content of 2.6 enzyme linked immunosorbent assays (ELISA) detection LPO
2.7 data processings and statistical analysis technique (every group of experiment is at least repeated 3 times)
3 test results
3.1 test specimens are as shown in table 1 below to the clearance rate of DPPH. free radical:
The clearance rate table of comparisons of table 1 embodiment 1-5 and control group
| Group | Clearance rate |
| Embodiment 1 | 52.67% |
| Embodiment 2 | 60.33% |
| Embodiment 3 | 71.12% |
| Embodiment 4 | 65.23% |
| Embodiment 5 | 56.58% |
| Control group | 12.69% |
Influence of the 3.2 anti-oxidant combinations to the HaCaT cell Proliferation vigor irradiated through UVB, as shown in table 2 below:
The survival rate table of comparisons of table 2 embodiment 1-5 and control group
| Group | Survival rate |
| Embodiment 1 | 69.17% |
| Embodiment 2 | 79.56% |
| Embodiment 3 | 85.59% |
| Embodiment 4 | 77.72% |
| Embodiment 5 | 53.42% |
| Control group | 21.36% |
Influence of the 3.3 anti-oxidant combinations to the HaCaT cell LPO content irradiated through UVB, as shown in table 3 below.
The HaCaT cell LPO content table of comparisons of 3 embodiment 1-5 of table and control group
| Group | LPO(μmol/L) |
| Embodiment 1 | 9.33 |
| Embodiment 2 | 7.41 |
| Embodiment 3 | 5.68 |
| Embodiment 4 | 6.83 |
| Embodiment 5 | 8.02 |
| Control group | 12.65 |
Comparison result is as follows:
Cell survival rate sequence: embodiment 3 > embodiment, 2 > embodiment, 4 > embodiment, 1 > embodiment, 5 > reference examples.
DPPH. free radical scavenging activity sorts: embodiment 3 > embodiment, 4 > embodiment, 2 > embodiment, 5 > embodiment, 1 > reference examples.
Peroxide (LPO) content sequence: embodiment 3 < embodiment, 4 < embodiment, 2 < embodiment, 5 < embodiment, 1 < reference examples.
Result explanation above, the addition percentage that the present invention combines have preferably range, have within this range well
Antioxidant effect is cooperateed with, is not measured The more the better.
Effete test embodiment 2 (stability test)
Stability test sample: embodiment 3, reference examples product.
Test method: inner quality standard is higher than national standard, professional standard (illumination 1 month, the high and low temperature test 3 months.) survey
Test result shows that embodiment 3 has good stability, and the illumination of reference examples and high temperature are all unstable, it may appear that discoloration is heavier
The case where.
Effete test embodiment 3 (security test)
Human skin enclosed type patch test results are shown, in 30 people0Example occursIt is positiveReaction, according to " cosmetics safety
Technical specification " (version in 2015) middle regulation, the tested material is to this batch subjectIt will notCause skin adverse reaction.
Effete test embodiment 4 (anti-oxidant test)
The present invention has made following test for its antioxidant effect:
4.1 experiment summaries:
Experiment purpose: being based on human fibroblasts (HFF-1) model, then test sample selects HFF-1 cytotoxicity
Concentration within the scope of safe concentration assesses the ability of test sample anti-oxidant (active oxygen ROS in scavenger-cell).
Sample message (title component additive amount) is as shown in table 4 below.
4 sample 1-7 of table and the formula material component and content (weight %) for compareing 1-3
4.2 reagents:
Cell strain is the fibroblast (HFF-1) in 25 generations.
DMEM culture medium (GIBCO, 500ml)；Fetal calf serum (GIBCO, 500ml)；Trypsase-EDTA (GIBCO,
100ml)；Phosphate buffer solution (HyClone, ml), I kit of collagen (Wuhan is magnificent), Fibroblast collagenase
(Wuhan is magnificent).
4.3 instruments:
Inverted microscope (OLYMPUSIX73)；Multi-function microplate reader (TECAN, Infinte M200Pro)；Incubator；From
Scheming；T25 Tissue Culture Flask；RTCA instrument；Cell detection plate；Cell counter.
4.4 experimentations:
1) sample treatment, reagent configuration, cell culture are not detailed.
2) sample is to HFF-1 cytotoxicity assay
Using multi-functional cell real-time cell analyzer (RTCA) test sample to dealed with medicine went.RTCA(Real
Time Cellular Analysis) special process is used, gold is incorporated in each cell growth hole bottom of tissue culture plate
Array of microelectrode sensors, to construct the cell impedance inspection in real time, dynamically, quantitatively tracking cellular morphology and Proliferation, Differentiation change
Sensing system is surveyed, it is this to change when cell of the adherent growth on microelectrode surface causes the change of adherent electrode interface impedance
Becoming with the real-time status of cell is in correlation, is obtained by the real-time detection to impedance value relevant to cell physiological function
Biological information.
Logarithmic growth phase HFF-1 cell is collected, E-plate culture plate is inoculated in, left and right for 24 hours is cultivated on RTCA instrument,
It is separately added into different samples.Cell controls 1 are wherein combined into different groups, using untreated fish group as cell controls group 2, every group
If 2 multiple holes, are placed in RTCA instrument, 37 DEG C, 5%CO2Environment, be further cultured for for 24 hours, 48h.
3) as the result is shown:
Sample 1, sample 2, sample 3, sample 4, sample 5, sample 6, control 1, control 2, control 3, no cytotoxicity, sample
7 increase in composition component ratio beyond cytotoxicity increases after upper limit of the present invention, exclude in follow-up test.As the result is shown such as
Shown in the following table 5.
Test result table 5 sample 1-7 and compare 1-3
4.4 anti-oxidant measurements
We select measurement active oxygen ROS evaluation sample oxidation resistance.
According to the HFF-1 cytotoxicity of detection, safe toxicity is selected to be tested, we select above-mentioned sample 1, sample 2,
Sample 3, sample 4, sample 5, sample 6, control 1, control 3, carry out ROS detection.
Logarithmic growth phase HFF-1 cell is inoculated in 96 orifice plate cultures for 24 hours.Sample-adding, using untreated fish group as cell blank
Control group, using the VC of 100 μ/ml as positive control.3 multiple holes are arranged in each concentration.After culture for 24 hours, according to ROS reagent
Box specification is measured.As a result as shown in table 6 below:
Test result table 6 sample 1-7 and compare 1-3, positive control and negative control
By upper table 6 it can be seen that sample 1, sample 2, sample 3, sample 4, sample 5, sample 6, control 1, control 3 all have
Inhibit the effect of ROS.Wherein, sample 5,6 function and effect of sample are better than positive control, and are significantly stronger than other test specimens；Sample 5
Effect it is most strong；Effect weakens a little instead after the increase of antioxidant composition amount in sample 6.Sample 1 is the composition of first three,
Control 3 is the 4th.
Conclusion: 1) the anti-oxidant combination (present invention) of sample 5 has synergistic function and effect；2) this composition
Additive amount be not it is The more the better, may be brought after adding cytotoxicity increase or antioxidant effect weaken.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
Without departing from the technical solutions of the present invention, to the above embodiments according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (8)
1. a kind of cosmetic composition with collaboration antioxidant effect, it is characterised in that: by weight percentage, comprising following
Raw material components:
Close Luo Muye/stem extraction 0.1-6%, hydrolysis Sodium Hyaluronate 0.01-0.8%, tocopherol 0.01-0.6%, palmityl
Tea extraction 0.01-0.6%, cosmetic matrix 92-99.87%.
2. the cosmetic composition with collaboration antioxidant effect as described in claim 1, it is characterised in that: percentage by weight
Include raw material components below than meter:
Close Luo Muye/stem extraction 1-5%, hydrolysis Sodium Hyaluronate 0.05-0.6%, tocopherol 0.02-0.4%, palmityl tea
Extract 0.02-0.4%, cosmetic matrix 93.6-98.93%.
3. the cosmetic composition with collaboration antioxidant effect as described in claim 1, it is characterised in that: the cosmetics
Excipient matrix include moisturizer, chelating agent, emollient, skin conditioning agent, emulsifier, solubilizer, essence, preservative, thickener,
One of skin sense adjustment, solvent, water are a variety of.
4. the cosmetic composition with collaboration antioxidant effect as claimed in claim 3, it is characterised in that: percentage by weight
Than meter, the cosmetic matrix is made of raw material components below:
Deionized water surplus.
5. the cosmetic composition with collaboration antioxidant effect as described in claim 3 or 4, it is characterised in that:
The solvent be selected from one of water, glycerol, butanediol, 1,3- propylene glycol, dipropylene glycol, polyglyceryl ether -26 or they
Mixture；
The emulsifier is selected from amino acids, sucrose ester, glyceride type, polyglycereol esters, spans, Tweens, poly- second two
The one or more of alcohols；
The moisturizing grease is selected from the one or more of silicone oil, vegetable fat, other Synthetic Oils etc.；；
The stabilizer is selected from carbomer, biogum class, the one or more of esters of acrylic acid and its modifier, cellulose family；
The PH regulator is selected from the one or more of arginine, triethanolamine, inorganic base；；
The skin conditioning agent is selected from each Plant Extracts, tunning, peptides, the one or more of inorganic matter；
The preservative is selected from the one or more of parabens, glycols, benzoic acids, Phenoxyethanol, sorb acids etc..
6. the cosmetic composition with collaboration antioxidant effect as claimed in claim 5, it is characterised in that: the pH is adjusted
Agent controls the pH range of cosmetic composition between 5.5-6.5.
7. the cosmetic composition with collaboration antioxidant effect as claimed in claim 5, it is characterised in that: be by following work
Skill step is made:
1) oil is added in oily phase pot, is stirred and heated to 80 DEG C, dissolution is complete；
2) water phase is added in water phase pot, is stirred and heated to 80 DEG C, dissolution is complete；
3) water phase and oil are mutually pumped into emulsion pot, emulsifying 6-8 minutes, stabilizer is added in emulsion pot and continues to emulsify 5-
8 minutes, PH is adjusted, keeps the temperature 20 minutes；
4) 37 DEG C are cooled to, remaining skin conditioning agent, preservative, aromatic is added, is stirred 30 minutes, after sample detection is qualified
Discharging.
8. having the cosmetic composition of collaboration antioxidant effect described in claim 5, which is characterized in that
The composition can be used for various State of cosmetics, including but not limited to surfactant, facial treatment essence, skin care mile, skin care
Lotion, skin care cream, color make-up, face cleaning.
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| CN201910846572.4A CN110448495A (en) | 2019-09-09 | 2019-09-09 | A kind of cosmetic composition with collaboration antioxidant effect |
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