WO2020258152A1

WO2020258152A1 - Kit for caring for the skin

Info

Publication number: WO2020258152A1
Application number: PCT/CN2019/093257
Authority: WO
Inventors: Lixuan KE; Zhipeng YAN
Original assignee: L'oreal
Priority date: 2019-06-27
Filing date: 2019-06-27
Publication date: 2020-12-30
Also published as: CN114222570A

Abstract

A kit comprises: 1) a first composition comprising at least one water insoluble substrate comprising carbon particles, wherein the carbon particles are distributed mainly within the insoluble substrate, and 2) a second composition comprising at least one aqueous phase and at least one emulsifier; wherein the first composition and the second composition are separately placed from one another; and the carbon particles and emulsifier are separately placed from one another. The kit can be used for caring for keratin materials, in particular the skin, for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects.

Description

KIT FOR CARING FOR THE SKIN

TECHNICAL FIELD

The present invention relates to an alginic system, especially to a kit caring for the skin. Further, the present invention relates to use of same, especially as a mask for caring for keratin materials, especially the skin.

BACKGROUND ART

Among all the compositions for caring for keratin materials, in particular the skin, masks are known to have high penetration efficacy on the keratin materials. As a result, a two-digit market growth of mask cosmetic products was seen.

In the market, the emulsion tissue masks are less popular than gel type mask. That may be because of the greasy and sticky skin finish after application. On the other hand, in recent years, liquid crystal has been emulsified and used in cosmetics. Liquid crystal emulsion has a constitution similar to skin lipids.

Charcoal, or carbon particle is known as a purifying agent thanks to its absorbing ability. Many products containing charcoal are seen on the market. In mask industry, it is known to use tissue masks with charcoal impregnated in the tissue. However, there are drawbacks. First of all, when charcoal is impregnated in the tissue, it is difficult to release them from the tissue, consequently, its absorbing ability is impacted. Secondly, because of sulfuration process, there will be some sulfide left in the tissue, and the residual of S in the tissue may cause the bad smell.

Based on the foregoing, there is a need for a new type of mask, which integrates two or more of the merits exhibited by the known mask types, but does not suffer from one or more problem (s) associated therewith.

AIMS OF INVENTION

Therefore, in one aspect, it is preferable to provide masks, which is capable of keeping the nourish and rich texture of the juice, while light and fresh skin finish.

In another aspect, it is preferable to provide masks, which show less greasiness and stickiness than normal emulsion masks.

In another aspect, it is preferable to provide masks, which are less greasy compared with normal tissue masks.

In another aspect, it is preferable to provide masks, which can provide improved purifying effect to keratin materials.

In another aspect, it is preferable to provide masks, which integrate all of the benefits described in the preceding aspects.

In another aspect, the present inventors discovered that the conception or gist of the present invention is applicable not only to the cosmetic field, but also to other fields like the medical field, then the masks of the preceding aspects may be broadened to kits, which show the benefits described herein in connection with these masks as well.

DISCLOSURE OF INVENTION

The present inventors have discovered that a specific combination of 1) a first composition comprising at least one water insoluble substrate comprising carbon particles, wherein the carbon particles are distributed mainly within the insoluble substrate, and 2) a second composition comprising at least one aqueous phase and at least one emulsifier.

One subject of the invention is thus to provide a kit comprising the first composition and the second composition separately placed from one another.

Another subject of the present invention is use of the second composition as juice or a part of juice for mask product, wherein the mask product comprises, separate from the second composition, a fabric (or tissue) comprising carbon particles according to the invention.

Another subject of the present invention is use of the kit according to the present invention for caring for keratin materials, especially the skin. This use may manifest itself as a process for caring for keratin materials, especially the skin, comprising the steps of compounding the first composition and the second composition of the kit at a predetermined weight ratio, and then applying to said keratin materials the thus obtained mixture.

Another subject of the present invention is use of the kit according to the present invention for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects, and so on. This use may manifest itself as a process for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects, comprising the steps of compounding the first composition and the second composition of the kit at a predetermined weight ratio, and then applying to a location in need of the thus obtained mixture

Other characteristics and advantages of the present invention will emerge more clearly on reading the description and the examples that follow.

DETAILED DESCRIPTION OF INVENTION

Other than in the operating examples, or where otherwise indicated, all numbers expressing quantities of components and/or reaction conditions are to be understood as being modified in all instances by the term "about" , meaning within 10%of the indicated number (e.g. "about 10%" means 9%-11%and "about 2%" means 1.8%-2.2%) .

Throughout the description, including the claims, the term "comprising a" should be understood as being synonymous with "comprising at least one" , unless otherwise mentioned. Moreover, the expression "at least one" used in the present description is equivalent to the expression "one or more" .

Throughout the description, including the claims, an embodiment defined with “comprising” or the like should be understood to encompass a preferable embodiment defined with “consisting substantially of” and a preferable embodiment defined with “consisting of” .

Preferably, the “keratin material” according to the present invention is the skin. By “skin” , we intend all the body skin. Still preferably, the keratin material is the face, or the neck, especially the face.

By “topical application” , it meant that the composition is applied or spread onto the surface of the keratin materials, such as at least one zone of the skin.

By a component X “distributed mainly within” a component Y, it meant that when components X and Y are brought into mix, less than 20%, preferably less than 10%, or less than 5%, or less than 1%, or less than 0.5%, of component X is present on surface of component Y.

By “alkali metal” , it refers to an element located in Group IA of the periodic table, such as sodium, potassium, lithium or a combination thereof, preferably sodium, potassium or a combination thereof.

The term "water-soluble or water-dispersible" means a compound which, when introduced into water at 25℃, at a mass concentration equal to 1%, make it possible to obtain a macroscopically homogeneous and transparent solution, i.e., a solution with a maximum light transmittance value, at a wavelength equal to 500 nm, through a sample 1 cm thick, of at least 60%and preferably of at least 70%.

In the application, unless specifically mentioned otherwise, contents, parts and percentages are expressed on a weight basis.

According to the present invention, the kit comprises a first composition and a second composition.

First composition

First of all, the first composition according to the present invention may comprise, consist substantially of, or consist of, at least one water insoluble substrate comprising carbon particles.

Water insoluble substrate

For the purpose of the present invention, the term “water insoluble” for the substrate means that the substrate is not dissolvable in water, nor does it break apart upon immersion in water.

Typically, the substrate may be a woven or nonwoven fabric made of a fiber of at least one water insoluble salt of polyvalent metal (also referred to as water insoluble polyvalent metal salt fiber hereinafter) solely or together with at least one other fiber chosen from natural fibers such as cotton, pulp, bamboo and cellulose fibers, semi-natural fibers such as viscose rayon fibers, synthetic fibers such as polyester fibers, polyethylene terephthalate fibers, polyethylene fibers and polypropylene fibers. Two or more selected from the other fibers may be used in combination.

The substrate can be made into a wide variety of shapes and forms such as flat pads, thick pads, or thin sheets of regular or irregular thickness, depending on the desired use and characteristic of the kit. Just for example, the substrate is typically designed to fit the area of the skin in the case of mask to which topical application is desired. To this end, when the mask is applied to the face, the substrate is designed to correspond to the shape of the face avoiding the eye, nostril, and mouth areas, as necessary. Non-limiting examples of the substrates useful in the present invention are described, for example, in the patent application WO 02/062132, or EP 2489286A.

In particular, the water insoluble substrate or the fabric may comprise the water insoluble polyvalent metal salt fiber, especially calcium alginate fiber, in an amount ranging from 10%to 99.9%by weight, especially from 10%to 50%by weight, relative to the total weight of the water insoluble substrate or the fabric.

In particular, the water insoluble substrate or the fabric may comprise the at least one other fiber, e.g., viscose fiber, in an amount ranging from 0%to 89.9%by weight, especially from 40%to 80%by weight, relative to the total weight of the water insoluble substrate or the fabric.

More particularly, a suitable nonwoven fabric of calcium alginate fiber is made of 20%by weight of calcium alginate fiber and 80%of lyocell fiber, commercially available from the Eastex company under the name E8080142.

Carbon particles

The first composition of the present invention can further comprise carbon particles, wherein the carbon particles distributed mainly within the insoluble substrate.

According to an embodiment of the present invention where the at least one water insoluble salt of polyvalent metal is produced into form of fiber which, solely or together with one or more other fibers, is formed into a water insoluble substrate, the water insoluble substrate can contain therein carbon particles.

For the purpose of the present invention, carbon particles are incorporated during the formation of fibers of the water insoluble salt of polyvalent metal. For example, the water insoluble salt of polyvalent metal, e.g., calcium alginate, is produced into fibers using any processes known in the art, e.g., spinning process, during which carbon particles are added. Subsequently, the fibers, solely or together with one or more other fibers, are formed into a water insoluble substrate, e.g., in form of a nonwoven fabric. Accordingly, carbon particles are distributed on surface of the substrate and within the substrate.

According to the present invention further treatment, e.g., spunlaced process, is preferably conducted, so as to remove substantially all particles on surface of the substrate. Then, the carbon particles are distributed mainly within the insoluble substrate.

For the purpose of the invention, the first composition may comprise 0.1%to 10%by weight, preferably 0.5%to 5%by weight, or preferably 1 to 3%by weight, of carbon particles, relatively to the total weight of the substrate.

For the purpose of the invention, the carbon particles have a particle size ranging from 0.01 to 20 μm, preferably 0.1 to 10 μm, or preferably 0.2 to 5 μm.

Water insoluble salt of polyvalent metal

According to the present invention, the substrate may be a woven or nonwoven fabric made of a fiber of at least one water insoluble salt of polyvalent metal solely or together with at least one other fiber.

The term “water insoluble” for the salt of polyvalent metal means that the salt is not dissolvable, e.g., having a solubility of less than 0.01g/100g of water or only slightly soluble, e.g., having a solubility of less than 0.5g/100g of water, in water, nor does it break apart in the bulk state upon immersion in water.

In particular, the at least one water insoluble salt of polyvalent metal may be present in form of powder, particulate, fiber or bulk state.

For the purposes of the present invention, the term "particulate" , when being used for the water insoluble salt of polyvalent metal, means that the salt is in the form of particles.

According to an embodiment, the first composition of the present invention may comprise the at least one water insoluble salt of polyvalent metal in a content ranging from 20%to 98%by weight, especially from 20%to 50%by weight, relative to the total weight of the substrate.

Specifically, water insoluble salt of polyvalent metal may be formed from an acid anion and a polyvalent metal cation, especially calcium, strontium, zinc, copper, manganese, aluminum, or mixtures thereof. The useful metal is preferably calcium, copper or a mixture thereof, more preferably calcium.

The acid to provide acid anion according to the present invention can be any known acid useful in cosmetic products, provided that the salt formed from the acid with the polyvalent metal is water insoluble or slightly soluble. The typical acids may be used comprise various inorganic acids, e.g., sulphate, carbonic acid, phosphoric acid meta-aluminic acid, silicic acid, and various organic acids, especially higher saturated or unsaturated fatty acids, in particular those having 18 or more carbon atoms, e.g., stearic acid and oleic acid, or polycarboxylic acids, especially e.g., alginic acid, oxalic acid, as long as the salt formed is water insoluble or slightly soluble.

More specifically, the at least one water insoluble salt of polyvalent metal may be an alginate, preferably chosen from calcium alginate, strontium alginate, zinc alginate, copper alginate, manganese alginate, or a mixture thereof, preferably calcium alginate or copper alginate, in particular calcium alginate.

The term "alginate" in particular means a salt of alginic acid. Alginic acid, a natural substance obtained from brown algae or from certain bacteria, is a polyuronic acid composed of two uronic acids linked together via 1, 4-glycoside bonds: β-D-mannuronic acid (M) andα-L-glucuronic acid (G) .

Water insoluble alginates, in which the principal cation is calcium, are specifically found in the fronds and stems of seaweeds of the class Phaeophyceae, examples of which are Fucus vesiculosus, Fucus spiralis, Ascophyllum nodosum, Macrocystis pyrifera, Alaria esculenta, Eclonia maxima, Lessonia nigrescens, Lessonia trabeculata, Laminaria japonica, Durvillea antarctica, Laminaria hyperborea, Laminaria longicruris, Laminaria digitata, Laminaria saccharina, Laminaria cloustoni, and Saragassum sp.

Suitable water insoluble alginates have a weight-average molecular weight of about 20,000 Daltons to about 500,000 Daltons. The weight-average molecular weight is calculated by first determining the intrinsic viscosity, then using the Mark-Houwink Sakurada Equation, as in Martinsen, et al, "Comparison of Different Methods for Determination of Molecular Weights and Molecular Weight Distribution of Alginates" (Carbohydr. Polym., 15, 171-193, 1991) .

According to an embodiment of the present invention, the at least one water insoluble salt of polyvalent metal may be present in form of fiber. Then, the fiber of the at least one water insoluble salt of polyvalent metal may, solely or together with one or more other fibers, be formed into a water insoluble substrate, which may correspond substantially to the first composition of the present invention.

Superabsorbent material

According to an embodiment of the present invention, the first composition may optionally comprise at least one superabsorbent material.

In particular, the at least one superabsorbent material may be present in form of powder, particulate, fiber or bulk state.

The superabsorbent material advantageously presents very great ability to absorb a liquid, and in particular water. In particular, it may present the capacity to absorb 15 times, or even 20 times to 50 times its own weight in water, e.g. about 25 times to 30 times.

The capacity of the superabsorbent material for absorbing liquid can be determined by implementing the following method.

A sample of the superabsorbent material in the powder, fiber, or bulk state, or arranged as a film or a sheet, is weighed while in the dry state (M _D) . For example it is possible to use a non-woven square web having a side of about 1 centimeter (cm) . In the context of the present method, the superabsorbent material is obtained in the "dry" state by being treated in a drying oven for about 4 hours (h) at about 50℃.

Water (or any other liquid that is to be absorbed by the material) is put into contact with the material. This can be done either by immersing the material in the liquid, or else by pouring the liquid onto the material. For example, the material may be immersed for a duration of about 1 minute (min) .

The quantity of water (or liquid) is used in excess so as to saturate the material completely, for example. The excess water (or liquid) is then eliminated, e.g. by drip-drying for about 2 min, and the material saturated in liquid is weighed (M _L) .

The difference Δ between the weight of the material when saturated in liquid and the weight of the material when dry represents the quantity of liquid that it has absorbed, which weight is compared with the dry weight of the material. The resulting value C is indicative of the capacity of the superabsorbent material to absorb the liquid, e.g. expressed in grams of liquid absorbed per gram of dry material:

The superabsorbent material may be selected from cellulose derivatives, alginates (not including the water insoluble alginates and the alkali metal alginic compounds described herein as the water soluble gelatinizing agent) and derivatives thereof, in particular derivatives such as propylene glycol alginate, or salts thereof, derivatives of polyacrylic acid or polymethacrylic acid, derivatives of poly (meth) acrylamide, derivatives of polyvinylpyrrolidone, derivatives of poly-vinyl ether, and mixtures thereof, amongst others.

In particular, the superabsorbent material may be selected from derivatives of chemically modified cellulose. For example it may be selected from carboxy-methyl cellulose, sodium carboxymethyl cellulose, carboxymethyl hydroxyethyl cellulose, carboxyethyl cellulose, hydroxyethyl cellulose, hydroxyethylethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, sodium methyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof.

It may also be selected from alkyl celluloses. These polymers are obtained by grafting an alkyl residue onto one or more hydroxy groups of the cellulose polymer to form the hydroxyalkyl derivative. These alkyl residues may be selected from the following groups: stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl, palmityl, oleyl, linonyl, ricinolyl, behenyl, and mixtures thereof. These hydroxyalkyl cellulose derivatives may also be subjected to chemical modification, e.g. using a carboxylic residue.

The superabsorbent material may also be selected from natural polymer derivatives, such as, for example, gellan gum and glucomannan and galactomannan polysaccharides extracted from seeds, vegetable fibers, fruit, seaweed, starch, plant resins, or indeed of microbial origin. For example, it may be selected from agar gum, guar gum, gum tragacanth, carrageenan gum, konjac gum, locust bean gum, gellan gum, xanthan gum, and mixtures thereof.

In particular, the first composition of the present invention may comprise the at least one superabsorbent material in a content ranging from 0%to 80%by weight, especially from 50%to 80%by weight, or even the rest, relative to the total weight of the first composition.

The kit according to the present invention comprises, separate from and isolated with the first composition (e.g. the water insoluble substrate) , a second composition. The second composition, as needed, impregnates, coats or is otherwise in contact with the first composition, so as to transform the texture of the first composition, for example, from tissue to gel.

Preferably, for a sufficient texture transformation, the weight ratio of the first composition (e.g. the water insoluble substrate or the fabric) to the second composition ranges from 1: 3 to 1: 20, preferably from 1: 8 to 1: 15.

Second Composition

The second composition of the present invention may comprise at least one emulsifier, and optionally other components, e.g., a chelating agent.

Emulsion form

The second composition according to the present invention may be in various forms, in particular in the form of emulsion, especially such as an oil/water emulsion or multiple emulsions.

An emulsion may have an oily or aqueous continuous phase. Such an emulsion may be, for example, an inverse (W/O) emulsion or a direct (O/W) emulsion, or alternatively a multiple emulsion (W/O/W or O/W/O) .

In particular, the second composition according to the present invention may be in the form of an oil-in-water (O/W) emulsion, or a multiple emulsion, preferably an oil-in-water (O/W) emulsion.

Emulsifier

Emulsifiers useful according to the present invention include nonionic surfactants, and especially esters of polyols and of fatty acids with a saturated or unsaturated chain containing, for example, from 8 to 24 carbon atoms and better still from 12 to 22 carbon atoms, and the oxyalkylenated derivatives thereof, i.e. derivatives containing oxyethylenated and/or oxypropylenated units, such as the glyceryl esters of C ₈-C ₂₄ fatty acids, and the oxyalkylenated derivatives thereof; the polyethylene glycol esters of C ₈-C ₂₄ fatty acids, and the oxyalkylenated derivatives thereof; the sorbitol esters of C ₈-C ₂₄ fatty acids, and the oxyalkylenated derivatives thereof; the sugar (sucrose, glucose or alkylglucose) esters of C ₈-C ₂₄ fatty acids, and the oxyalkylenated derivatives thereof; fatty alcohols; fatty alcohol ethers; the sugar ethers of C ₈-C ₂₄ fatty alcohols, and mixtures thereof.

Glyceryl esters of fatty acids that may especially be mentioned include glyceryl stearate (glyceryl monostearate, distearate and/or tristearate) (CTFA name: glyceryl stearate) or glyceryl ricinoleate, and mixtures thereof.

Polyethylene glycol esters of fatty acids that may especially be mentioned include polyethylene glycol stearate (polyethylene glycol monostearate, distearate and/or tristearate) and more especially polyethylene glycol 50 OE monostearate (CTFA name: PEG-50 stearate) and polyethylene glycol 100 OE monostearate (CTFA name: PEG-100 stearate) , and mixtures thereof.

Examples of fatty alcohol that may be mentioned include fatty alcohols containing from 8 to 30 carbon atoms and especially from 10 to 22 carbon atoms, such as cetyl alcohol, stearyl alcohol or cetearyl alcohol.

Examples of fatty alcohol ethers that may be mentioned include polyethylene glycol ethers of fatty alcohols containing from 8 to 30 carbon atoms and especially from 10 to 22 carbon atoms, such as polyethylene glycol ethers of cetyl alcohol, of stearyl alcohol or of cetearyl alcohol (mixture of cetyl alcohol and stearyl alcohol) . Examples that may be mentioned include ethers comprising from 1 to 200 and preferably from 2 to 100 oxyethylene groups, such as those of CTFA name Ceteareth-20 and Ceteareth-30, and mixtures thereof.

Nonionic surfactants which may be particularly mentioned include oxyalkylenated (more particularly polyoxyethylenated) esters of fatty acids and of glycerol; oxyalkylenated esters of fatty acids and of sorbitan; oxyalkylenated (oxyethylenated and/or oxypropylenated) esters of fatty acids, such as the PEG-100 stearate/glyceryl stearate mixture sold, for example, by ICI under the name Arlacel 165; or oxyalkylenated (oxyethylenated and/or oxypropylenated) ethers of fatty alcohols; esters of sugars, such as sucrose stearate; ethanolamine and its derivatives, such as cocamide MEA.

Sugar ethers that may especially be mentioned are alkylpolyglucosides (APGs) . An alkylpolyglucoside can be used alone or as a mixture of two or more alkylpolyglucosides. An alkylpolyglucoside generally has a formula (I) of:

R (O) (G) _n (I)

wherein:

R is a linear or branched C _8-22 alkyl, preferably C _8-16 alkyl; G is a residual of a sugar; and n ranges from 1 to 5, preferably from 1.05 to 2.

The sugar for the residue G of formula (I) can be selected from the group consisting of glucose, dextrose, fructose, galactose, sucrose, ribose, lactose, maltose, xylose, mannose, cellulose dextran, or starch.

Alkylpolyglucosides useful according to the present invention comprise, for example, decylglucoside, for instance the product sold under the name Mydol 10 by the company Kao Chemicals, the product sold under the name Plantaren 2000 by the company Henkel, and the product sold under the name Oramix NS 10 by the company SEPPIC; caprylyl/capryl glucoside, for instance the product sold under the name Oramix CG 110 by the company SEPPIC or under the name Lutensol GD 70 by the company BASF; laurylglucoside, for instance the products sold under the names Plantaren 1200 N and Plantacare 1200 by the company Henkel; cocoglucoside, for instance the product sold under the name Plantacare 818/UP by the company Henkel; cetostearyl glucoside optionally as a mixture with cetostearyl alcohol, sold, for example, under the name Montanov 68 by the company SEPPIC, under the name Tego-Care CG90 by the company Goldschmidt and under the name Emulgade KE3302 by the company Henkel; arachidyl glucoside,

According to an embodiment of the present invention, the APG can be used as a mixture with a fatty alcohol, especially a fatty alcohol having 8-30 carbon atoms, e.g., 10-20 carbon atoms. Preferably, for such a mixture, the alkylpolyglucoside and the fatty alcohol have similar carbon atoms, e.g., with a difference less than 5, in particular less than 3, or less than 2. More preferably, the alkylpolyglucoside and the fatty alcohol used in the mixture have same carbon atoms. For example, the alkylpolyglucoside and the fatty alcohol in the mixture can have a same alkyl moiety.

The mixtures of alkylpolyglucoside/fatty alcohol are known in the art, see, for example, WO 9847610 and WO 9513863.

Examples of mixtures of alkylpolyglucoside/fatty alcohol can comprise the products sold under the name of Montanov series by the company SEPPIC:

-myristyl alcohol/myristyl glucoside: Montanov 14;

-isostearyl alcohol/isostearyl glucoside: Montanov WO 18.

-cetylstearyl alcohol/cetylstearyl glucoside: Montanov 68;

-cetylstearyl alcohol/coco glucoside: Montanov 82;

-arachidyl alcohol/behenyl alcohol/arachidyl glucoside: Montanov 202;

-C _14-22 alcohol/C _14-22 alkyl glucoside: Montanov L; and

-coconut alcohol/coco glucoside: Montanov S.

Other useful APGs can comprise, such as: decyl glucoside and lauryl glucoside, sold, for example, by the company Henkel under the respective names Plantaren 2000 and Plantaren 1200. In addition, a mixture of cetostearyl glucoside with cetostearyl alcohol, in addition to Montanov 68, is also sold, for example, under the name Tegocare CG90 by the company Goldschmidt and under the name Emulgade KE3302 by the company Henkel.

According to the present invention, the emulsifier is used in an amount of 0.01-20 wt%, preferably 0.1-15 wt%, or 0.2-10 wt%, based on the total weight of the second composition.

According to the present invention, when the first composition is mixed with the second composition, the water insoluble polyvalent metal ion donator reacts with salt in solution and releases the polyvalent metal ions, wherein the metal ions in the solution react with the water soluble gelatinizing agent and start to gelatinize on the tissue surface.

Chelating agent

The second composition according to the present invention can comprise at least one chelating agent of the polyvalent metal ion, to facilitate the texture transformation, and specially, to boost at least the moisture or actives delivery capacity. The water soluble chelating agent of the polyvalent metal ion is preferably water-soluble.

According to the present invention, when the first composition is mixed with the second composition, the chelating agent will chelate the polyvalent metal ion, e.g., Ca ²⁺ ion, in the tissue, and make the alginate calcium loss the Ca ²⁺ and become soluble. So that the carbon can be released from the tissue, and the carbon will not be absorbed in the gel.

According to the present invention, the useful chelating agent of the polyvalent metal ion comprises aminocarboxylic acids, e.g., elhylenediamine tetraacetic acid (EDTA) , aminotriacetic acid, diethylene triaminepentaacetic acid, and in particular the alkali metal salt thereof, e.g., N, N-bis (carboxymethyl) glutamic acid, tetrasodium EDTA, tetrasodium salt of N, N-bis (carboxymethyl) glutamic acid (glutamic acid diacetic acid, GLDA) ; hydroxyl carboxylic acids, e.g., citric acid, tartaric acid, glucuronic acid, succinic acid, ethylenediamine disuccinic acid (EDDS) , and in particular the alkali metal salt thereof; hydroxyl aminocarboxylic acids, e.g., hydroxyethylethylenediamine triacetic acid (HEDTA) , dihydroxyethylglycine (DEG) , and in particular the alkali metal salt thereof; polyphosphonic acid, and in particular the alkali metal salt thereof; other phosphor-containing organic acid, e.g., phytic acid, and in particular the alkali metal salt thereof, e.g., sodium phytate, potassium phytate polycarboxylic acid, e.g., polyacrylic acid, polymethacrylic acid, and in particular the alkali metal salt thereof.

In one embodiment, the at least one water soluble chelating agent of the polyvalent metal ion is an alkali metal hydroxyl polycarboxylate represented by an alkane containing from 1 to 4 carbon atoms, preferably containing 2 or 3 carbon atoms, substituted by 1, 2, or 3 hydroxyl groups (-OH) , preferably by one (1) hydroxyl group, and further substituted by 2, 3, 4 or 5 carboxylate groups (-COOM) , preferably by 2 or 3 carboxylate groups (-COOM) , wherein the multiple groups M independently represent H or alkali metal, with the proviso that at least one of the groups M represents alkali metal, such as Na, K or Li, preferably all groups M represent alkali metal, such as Na, K or Li, preferably Na. More specifically, the at least one alkali metal hydroxyl polycarboxylate may be chosen from sodium tartrates, potassium tartrates, potassium citrates, and hydrates thereof, preferably sodium citrates, in particularly trisodium citrate. Herein, sodium citrates are used to indicate monosodium citrate, disodium citrate and trisodium citrate, and other alkali metal hydroxyl polycarboxylates may be understood in a similar way.

Amongst others, the alkali metal mentioned above is preferably sodium or potassium, in particular sodium. Accordingly, preferable chelating agents can comprise sodium citrate, potassium citrate, sodium alginate or potassium alginate, especially sodium citrate.

According to an embodiment, the at least one chelating agent is present in the second composition from 0.01%to 1%by weight, 0.1%to 0.5%by weight, preferably from 0.1%to 0.3%by weight, relative to the total weight of the second composition.

Fatty phase

The second composition according to the invention is preferably an O/W emulsion. Accordingly, the second composition may comprise at least one fatty phase/oil phase that is liquid at room temperature and atmospheric pressure, and especially at least one oil as mentioned below.

Specifically, the presence of at least one oil is advantageous insofar as it facilitates the application of the composition and affords emollience.

According to the present invention, the term "oil" means a water-immiscible non-aqueous compound that is liquid at room temperature (25℃) and at atmospheric pressure (760 mmHg) .

An oily phase that is suitable according to the invention may comprise hydrocarbon-based oils, silicone oils, fluoro oils or non-fluoro oils, or mixtures thereof.

The oils may be volatile or non-volatile.

They may be of animal, plant, mineral or synthetic origin. According to one embodiment variant, oils of plant origin are preferred.

The term "volatile oil" means any non-aqueous medium that is capable of evaporating on contact with the skin or the lips in less than one hour, at room temperature and atmospheric pressure. The volatile oil is a cosmetic volatile oil, which is liquid at room temperature. More specifically, a volatile oil has an evaporation rate of between 0.01 and 200 mg/cm ²/min, limits inclusive.

The term "non-volatile oil" means an oil that remains on the skin or the keratin fibre at room temperature and atmospheric pressure. More specifically, a non-volatile oil has an evaporation rate strictly less than 0.01 mg/cm ²/min.

To measure this evaporation rate, 15 g of oil or oil mixture to be tested are placed in a crystallizing dish 7 cm in diameter, placed on a balance that is in a large chamber of about 0.3 m ³ which is temperature-regulated, at a temperature of 25℃, and hygrometry-regulated, at a relative humidity of 50%. The liquid is allowed to evaporate freely, without stirring it, while providing ventilation by means of a fan (Papst-Motoren, reference 8550 N, rotating at 2700 rpm) placed in a vertical position above the crystallizing dish containing said oil or said mixture, the blades being directed towards the crystallizing dish, 20 cm away from the bottom of the crystallizing dish. The mass of oil remaining in the crystallizing dish is measured at regular intervals. The evaporation rates are expressed in mg of oil evaporated per unit of area (cm ²) and per unit of time (minutes) .

For the purposes of the present invention, the term “silicone oil” means an oil comprising at least one silicon atom, and especially at least one Si-O group.

The term “fluoro oil” means an oil comprising at least one fluorine atom.

The term “hydrocarbon-based oil” means an oil mainly containing hydrogen and carbon atoms.

The oils may optionally comprise oxygen, nitrogen, sulfur and/or phosphorus atoms, for example in the form of hydroxyl or acid radicals.

Advantageously, the second composition of the invention may comprise from 10%to 50%by weight and preferably from 20%to 40%by weight of oil (s) relative to the total weight of the said second composition.

Aqueous phase

The second composition according to the present invention may comprise at least one aqueous phase.

The at least one aqueous phase comprises water.

The aqueous phase may also comprise water-miscible organic solvents (at room temperature: 25℃) , for instance monoalcohols containing from 2 to 6 carbon atoms, such as ethanol or isopropanol; polyols especially containing from 2 to 20 carbon atoms, preferably containing from 2 to 10 carbon atoms and preferentially containing from 2 to 6 carbon atoms, such as glycerol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol or diethylene glycol; glycol ethers (especially containing from 3 to 16 carbon atoms) such as mono-, di-or tripropylene glycol (C ₁-C ₄) alkyl ethers, mono-, di-or triethylene glycol (C ₁-C ₄) alkyl ethers, and mixtures thereof.

The aqueous phase may also comprise any water-soluble or water-dispersible compound that is compatible with an aqueous phase, such as hydrophilic gelling agents, preservatives or surfactants, and mixtures thereof.

In particular, the second composition of the present invention may comprise the at least one aqueous phase in a content ranging from 10%to 85%by weight, especially from 20%to 85%by weight, and more particularly from 50%to 80%by weight, relative to the total weight of the second composition.

In order to form the emulsion of the second composition according to the present invention, the emulsifier can be added into the fatty phase, and the mixture obtained is then added to the aqueous phase.

Active agents

According to an embodiment of the present invention, the first composition may comprise at least one active agent.

According to an embodiment of the present invention, the second composition may comprise at least one active agent.

When the first composition includes the at least one active agent, it may be incorporated into the first composition in particular by means of an alternating electric field. The active agent (s) may be incorporated in particular in the powder state.

Amongst all of the active agents that can be used in the present invention, particular mention can be made of: α- or β-hydroxy acids such as lactic acid, glycolic acid, 5-octanoylsalicyclic acid, α-hydroxydecanoic acid, α-hydroxylauric, tartaric acid, glucuronic acid, galacturonic acid, acrylic acid, α-hydroxybutyric acid, α-hydroxyisobutyric acid, malic acid, mandelic acid, phosphoric acid, pyruvic acid, lactobionic acid, and salicylic acid.

It is also possible to use anti-acne agents, such as salicylic acid or benzoyl peroxide, octopirox, dextrorotary and levorotary sulfur-containing amino acids, their salts, and their N-acetyl derivatives such as N-acetyl cysteine, or agents seeking to prevent aging of the skin and/or to improve its state, for example the above-mentioned α-and β-hydroxy acids, retinoids such as retinoic acid, retinol, and its esters, such as, for example, retinyl propionate, and retinyl acetate, or retinyl palmitate, niacinamide, allantoin, extracts of aloe, azelaic acid, bisabolol, phytic acid, collagen, or agents stimulating the formation of collagen, vitamins such as vitamin C or derivatives thereof, such as ascorbyl glucoside, vitamin E or derivatives thereof, vitamin A or derivatives thereof, vitamin F or derivatives thereof, dextrorotary and levorotary sulfur-containing amino acids and derivatives thereof as mentioned above, elastin, N-acetyl D-glucosamine, luteolin, or antioxidants such as green tea or active fractions thereof, glycerin, laponite, caffeine, essential aromatic oils, coloring agents, free-radical scavengers, moisturizers, depigmenting agents, agents for improving the color of the skin such as artificial-tanning agents of the dihydroxyacetone or tyrosin ester type, liporegulators, softeners, anti-wrinkle agents, keratolytic agents, fresheners, deodorants, anesthetics, nourishing agents, and mixtures thereof. It is also possible to use bleaching agents such as kojic acid, ascorbyl phosphates, ascorbyl glucosides, ascorbic acid, and mixtures thereof.

It is also possible to use active agents for improving the condition of the skin in the case of mask, such as moisturizers or agents serving to improve the natural lipid barrier, such as ceramides, cholesterol sulfates, and/or fatty acids, and mixtures thereof. It is also possible to use enzymes that have activity on the skin, such as proteases, lipases, cerebrosidases, and/or melanases, and mixtures thereof.

As other examples of active agents that can be suitable for implementing the present invention there are agents for drugs, peptides, proteins, detectable labels, contrast reagents, pain-killing, anesthetics, antibacterial agents, anti-yeast agents, antifungal agents, antiviral agents, anti-dermititis agents, anti-pruritic agents, anti-emetics, vascular protectors, agents against motion sickness, anti-irritants, anti-inflammatory agents, immunomodulators, anti-hyperkeratolytic agents, agents for treating dry skin, antiperspirants, anti-psoriatic agents, antidandruff agents, anti-aging agents, anti-asthmatic agents and bronchodilators, sunscreen agents, antihistamines, healing agents, corticosteroids, tanning agents, and mixtures thereof.

The content of the at least one active agent in the first composition and/or in the second composition may be adjusted as a function of the intended purpose of the kit.

Alkali metal hyaluronic compound

Hyaluronic compound may be also used as an active agent according to the present invention. The hyaluronic compound is preferably an alkali metal hyaluronic compound.

The term "alkali metal hyaluronic compound" in particular means alkali metal salts of hyaluronic acid (hyaluronates) or derivatives thereof. The alkali metal hyaluronic compound is water-soluble.

In the context of the present invention, the term "hyaluronic acid or derivatives thereof" covers in particular the basic unit of hyaluronic acid of formula:

It is the smallest fraction of hyaluronic acid comprising a disaccharide dimer, namely D-glucuronic acid and N-acetylglucosamine.

The term "hyaluronic acid or derivatives thereof" also comprises, in the context of the present invention, the linear polymer comprising the polymeric unit described above, linked together in the chain via alternating β (1, 4) and β (1, 3) glycosidic linkages, having a molecular weight (Mw) that can range between 380 and 13 000 000 daltons. This molecular weight depends in large part on the source from which the hyaluronic acid is obtained and/or on the preparation methods.

In the natural state, hyaluronic acid is present in pericellular gels, in the base substance of the connective tissues of vertebrate organs such as the dermis and epithelial tissues, and in particular in the epidermis, in the synovial fluid of the oints, in the vitreous humor, in the human umbilical cord and in the crista galli apophysis.

Thus, the term "hyaluronic acid or derivatives thereof" comprises all the fractions or subunits of hyaluronic acid having a molecular weight in particular within the molecular weight range recalled above.

By way of illustration of the various hyaluronic acid fractions, reference may be made to the document "Hyaluronan fragments: an information-rich system", R. Stern et al., European Journal of Cell Biology 58 (2006) 699-715, which reviews the listed biological activities of hyaluronic acid according to its molecular weight.

According to a preferred embodiment of the present invention, the hyaluronic acid fractions suitable for the use covered by the present invention have a molecular weight of between 50 000 and 5 000 000, in particular between 100 000 and 5 000 000, especially between 400 000 and 5 000 000 Da. In this case, the term used is high-molecular-weight hyaluronic acid.

Alternatively, the hyaluronic acid fractions that may also be suitable for the use covered by the present invention have a molecular weight of between 50 000 and 400 000 Da. In this case, the term used is intermediate-molecular-weight hyaluronic acid.

Alternatively again, the hyaluronic acid fractions that may be suitable for the use covered by the present invention have a molecular weight of less than 50 000 Da. In this case, the term used is low-molecular-weight hyaluronic acid.

Finally, the term "hyaluronic acid or derivatives thereof" also comprises hyaluronic acid esters in particular those in which all or some of the carboxylic groups of the acid functions are esterified with oxyethylenated alkyls or alcohols, containing from 1 to 20 carbon atoms, in particular with a degree of substitution at the level of the D-glucuronic acid of the hyaluronic acid ranging from 0.5 to 50%.

More specifically, hyaluronic acid or hyaluronates may be reacted with an alkylene oxide, such as ethylene oxide or propylene oxide, to form polyglycol hyaluronates. The polyglycol segment is bonded to hyaluronic acid through the carboxyl group (s) . Typically, hyaluronic acid or hyaluronates react with propylene oxide to form polypropylene glycol hyaluronates, while react with ethylene oxide to form polyethylene glycol hyaluronates.

Further, mention may be made of methyl, ethyl, n-propyl, n-pentyl, benzyl and dodecyl esters of hyaluronic acid. Such esters have in particular been described in D. Campoccia et al. "Semisynthetic resorbable materials from hyaluronan esterification" , Biomaterials 19 (1998) 2101-2127.

The molecular weights indicated above are also valid for the hyaluronic acid esters.

Adjuvants

In a known manner, the second composition of the present invention may also contain adjuvants that are common in cosmetics and/or dermatology, such as preserving agents, antioxidants, pH modifiers (acidic or basic) , fragrances, fillers, bactericides, odour absorbers, colorants (pigments and dyes) , emulsifiers, and also lipid vesicles.

Needless to say, a person skilled in the art will take care to select this or these optional additional compound (s) , and/or the amount thereof, such that the benefits of the second composition according to the present invention are not, or are not substantially, adversely affected by the envisaged addition.

Method and use

The first composition and the second composition according to the present invention can be generally prepared according to the general knowledge of a person skilled in the art. Nevertheless, it is to be understood that a person skilled in the art can choose the method of preparation, on the basis of his/her general knowledge, taking into account the nature of the constituents used, for example, their solubility in the vehicle, and the application envisaged for the compositions or the kit.

According to an embodiment, the kit according to the present invention can be used for caring for keratin materials, especially the face. This use may manifest itself as a process for caring for keratin materials, especially the face, comprising the steps of compounding the first composition and the second composition of the kit at a predetermined weight ratio, and then applying to said keratin materials the thus obtained mixture as a mask.

According to an embodiment, the kit according to the present invention can be used for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects, and so on. This use may manifest itself as a process for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects, comprising the steps of compounding the first composition and the second composition of the kit at a predetermined weight ratio, and then applying to a location in need of the thus obtained mixture as a mask or stuffing.

Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the present invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contain certain errors necessarily resulting from the standard deviation found in their respective measurements. The following examples are intended to illustrate the present invention without limiting the scope as a result.

EXAMPLES

The ingredient amounts/concentrations in the compositions/formulas described below are expressed in %by weight, relative to the total weight of each composition/formula.

Example 1

I. Preparation

The invention formulas A and B, and comparative formula A were prepared, as the second composition.

Table 1

In table 1, comparative A did not contain MONTANOV 202 as compared with the invention formula A and B

Protocol of preparation of the second composition using the formulas in table 1: ingredients in phase A and B were added in the baker, heated to 80℃ until melting; phase C was heated to 80degree; phases A+B were added into phase C, and homogenized until uniform, cooled down to room temperature.

Protocol of preparation of masks: 33g of each of the formulas A to B and comparative A, respectively, were placed together with a nonwoven fabric with a weight of 1.3g, made of 20%by weight of calcium alginate fiber (containing 5%carbon particles, relative to the total weight of the alginate fiber) and 80%of lyocell fiber, sold by the Eastex company under the name E8080142, so as to provide masks A and B, and comparative mask A, respectively.

II. Evaluation of the invention and comparative masks

The present invention and comparative masks were evaluated using the following protocols.

Method for test of haze/blur effect

Normally, if the specular light on face is strong, then it will give a greasy look. The haze or blur effect is expected for less greasy appearance. So, the blur effect of the 3 formulas were checked, by haze meter and compare the greasiness of the formula.

The test was conducted by: coating 25μm of masks A and B, and comparative mask A, drying up for 1 hours; measuring the value of the haze light strength of the film by Hazemeter 4725. The value was from 0-100. The higher the value, the stronger the bluer effect.

Method for test of juice thickness and greasiness

16 panelists evaluated the juice thickness and greasiness by their fingers.

Evaluation process: Applying 0.5ml juice on the back of hand, touching the juice by finger, and moving the finger in a circular motion to check the thickness and greasiness of the juice. Each panelist gave the score of thickness and greasiness from 0 to 15. The higher thickness and greasiness the higher score was given.

Evaluation index: grading from poor to excellent which was classified in the following 4 categories based on the scores: “very thick” (>12) , “thick” (8-12) , “less thick” (4-8) , “very fluid” (0-4) .

Evaluation index: grading from poor to excellent which was classified in the following 4 categories based on the scores: “very greasy” (>12) , “greasy” (8-12) , “not greasy” (4-8) , “fresh” (0-4) .

Method for test of skin finish greasiness evaluation

16 panelists evaluated the degree of greasiness of skin by the tactile way when slight moving finger pulp on the face.

Evaluation process: applying the mask on face for 15 minutes and then taking off and massaging the skin; and perceiving the greasiness of skin by moving finger pulp on the face. Then each panelist gave the score from 0 to 15. The more greasiness, the high score was given.

The results obtained were detailed in the table hereunder:

Table 2

	Mask A	Mask B	Comparative A
Haze effect	30	40	4
Juice thickness	13	15	10
Juice greasiness	10	15	10
Skin finish greasiness	4	6	6

III. Conclusion

The mask of the present invention A&B were superior in the blur effect which shows less specular light of the skin and generate the clean image. The texture contracts were also higher than the comparative A, since at the beginning the textures were thicker than comparative A, while the skin finish effects were fresher or equal to comparative A. The example showed the superiors of liquid crystal emulsion.

Example 2

I. Preparation

The following invention formula C was prepared, corresponding to the second composition:

Then, the invention tissue E, F, and comparative tissue G were prepared, corresponding to or comparing with the first composition:

Following masks were produced:

Invention mask C: formula C+tissue E;

Invention mask D: formula C+tissue F;

Comparative mask E: formula C+tissue G;

II. Evaluation of the invention and comparative masks

Method for skin finish greasiness evaluation

16 panelists evaluated the greasiness of the mask after use.

The results obtained were detailed in the table hereunder:

Table 3

	Invention mask C	Invention mask D	Comparative mask E
Skin finish greasiness	4	2	7

III. Conclusion

The masks of the present invention were superior in reducing the greasiness feeling of the skin. The higher content of carbon particle content, the better greasiness reducing effect. The example showed the superiors of carbon particle.

The evaluation of adsorption was conducted on the invention tissue E and F, and comparative tissue G, by placing a dry tissue into blue ink solution, and observing the color fading of the solution. It was observed that the tissue F had the best adsorption effect, i.e., blue ink color faded from light blue to no color transparent; tissue E had good adsorption effect, the color of the blue ink had faded a lot; whereas the tissue G had no adsorption effect, the color of the blue ink didn’t change.

Example 3

I. Preparation

The following invention formula D&E was prepared, corresponding to the second composition:

In formula D, there was no charcoal powder, while in formula E, the equivalent charcoal powder was added in the juice.

Then, the invention tissue E, and comparative tissue G were prepared, corresponding to or comparing with the first composition:

Following masks were produced:

Invention mask F: formula D+tissue E in separation

Comparative mask G: formula E+tissue G in one sachet

In invention mask F and comparative mask G, the charcoal powder content was the s ame.

II. Evaluation of the invention and comparative masks

Method for stability of the formula

2 formulas were placed in the lumisizer with 45degree and 2000rpm centrifuges, for 2 hours.

	Formula D	Formula E
Appearance of the bulk	White fluid emulsion	Black fluid emulsion
Stability of the bulk	Stay unify	Black charcoal deposited

Appearance of Invention Mask F and G shows as below

III. Conclusion

The mask of the present invention was superior in the stability on the lower viscosity emulsion format. And for the fresh mix type of kit, the present invention was able to add more high content of black charcoal powder compare to the one sachet format. The example showed the superiors of the separation of black charcoal in the tissue part.

The foregoing description illustrates and describes the present disclosure. Additionally, the disclosure shows and describes only the preferred embodiments of the disclosure, but, as mentioned above, it is to be understood that it is capable of changes or modifications within the scope of the concept as expressed herein, commensurate with the above teachings and/or skill or knowledge of the relevant art. The described hereinabove are further intended to explain best modes known of practicing the disclosure and to enable others skilled in the art to utilize the disclosure in such, or other embodiments and with the various modifications required by the particular applications or uses disclosed herein. Accordingly, the description is not intended to limit the disclosure to the form disclosed herein. Also it is intended that the appended claims be construed to include alternative embodiments.

All publications, patents and patent applications cited in this specification are herein incorporated by reference, and for any and all purposes, as if each individual publication, patent or patent application were specifically and individually indicates to be incorporated by reference. In this case of inconsistencies, the present disclosure will prevail.

Claims

A kit, comprising:

1) a first composition comprising at least one water insoluble substrate comprising carbon particles, wherein the carbon particles are distributed mainly within the insoluble substrate, and

2) a second composition comprising at least one aqueous phase and at least one emulsifier;

wherein the first composition and the second composition are separately placed from one another; and the carbon particles and emulsifier are separately placed from one another.
Kit according to claim 1, wherein the substrate is a woven or nonwoven fabric made of a fiber of at least one water insoluble salt of polyvalent metal solely or together with one or more other fibers chosen from natural fibers such as cotton, pulp, bamboo and cellulose fibers, semi-natural fibers such as viscose rayon fibers, synthetic fibers such as polyester fibers, polyethylene terephthalate fibers, polyethylene fibers and polypropylene fibers, or a mixture thereof.
Kit according to claim 2, wherein the water insoluble substrate comprises 10%to 99.9%by weight, especially from 10%to 50%by weight of the fiber of at least one water insoluble salt of polyvalent metal, especially calcium alginate fiber, and 0%to 89.9%by weight, especially from 40%to 80%by weight, of the one or more other fiber, e.g., viscose fiber, relative to the total weight of the water insoluble substrate or the fabric.
Kit according to anyone of the preceding claims, wherein the at least one water insoluble salt of polyvalent metal is a water insoluble alginate chosen from calcium alginate, strontium alginate, zinc alginate, copper alginate, manganese alginate, or a mixture thereof, preferably calcium alginate.
Kit according to anyone of the preceding claims, wherein the first composition comprises 0.1%to 10%by weight, preferably 0.5%to 5%by weight, or preferably 1 to 3%by weight, of carbon particles, relatively to the total weight of the substrate.
Kit according to anyone of the preceding claims, wherein the chelating agent is selected from the group consisting of chelating agents can comprise sodium citrate, potassium citrate, sodium alginate, potassium alginate, disodium EDTA, and tetrasodium EDTA.
Kit according to anyone of the preceding claims, wherein the weight ratio of the first composition to the second composition ranges from 1: 3 to 1: 20, preferably from 1: 8 to 1: 15.
Kit according to anyone of the preceding claims, wherein the emulsifier is selected from the group consisting of the glyceryl esters of C ₈-C ₂₄ fatty acids, and the oxyalkylenated derivatives thereof; the polyethylene glycol esters of C ₈-C ₂₄ fatty acids, and the oxyalkylenated derivatives thereof; the sorbitol esters of C ₈-C ₂₄ fatty acids, and the oxyalkylenated derivatives thereof; the sugar esters of C ₈-C ₂₄ fatty acids, and the oxyalkylenated derivatives thereof; fatty alcohol ethers; the sugar ethers of C ₈-C ₂₄ fatty alcohols, and mixtures thereof.
Kit according to claim 8, wherein the sugar ethers are alkylpolyglucosides having a formula (I) of:

R (O) (G) _n (I)

wherein:

R is a linear or branched C _8-22 alkyl, preferably C _8-16 alkyl;

G is a residual of a sugar selected from the group consisting of glucose, dextrose, fructose, galactose, sucrose, ribose, lactose, maltose, xylose, mannose, cellulose dextran, or starch; and

n ranges from 1 to 5, preferably from 1.05 to 2.
Kit according to claim 9, wherein the alkylpolyglucoside is used as a mixture with a fatty alcohol having 8-30 carbon atoms, e.g., 10-20 carbon atoms, wherein the alkylpolyglucoside and the fatty alcohol have similar carbon atoms with a difference less than 5, or less than 2, or being 0.
Kit according to claim 10, wherein the mixture of alkylpolyglucoside/fatty alcohol is selected from the group consisting of: myristyl alcohol/myristyl glucoside, isostearyl alcohol/isostearyl glucoside, cetylstearyl alcohol/cetylstearyl glucoside, cetylstearyl alcohol/coco glucoside, arachidyl alcohol/behenyl alcohol/arachidyl glucoside, arachidyl alcohol/behenyl alcohol/arachidyl glucoside, C _14-22 alcohol/C _14-22 alkyl glucoside, and coconut alcohol/coco glucoside.
Kit according to anyone of the preceding claims, wherein the emulsifier is selected from the group consisting of: glyceryl stearate, glyceryl ricinoleate, polyethylene glycol stearate, cetyl alcohol, stearyl alcohol or cetearyl alcohol, arachidyl alcohol/behenyl alcohol/arachidyl glucoside, isostearyl alcohol/isostearyl glucoside, cetylstearyl alcohol/cetylstearyl glucoside, and mixtures thereof; preferably a mixture of glyceryl stearate, cetearyl alcohol and arachidyl alcohol/behenyl alcohol/arachidyl glucoside.
Kit according to anyone of the preceding claims, wherein the emulsifier is used in an amount of 0.01-20 wt%, preferably 0.1-15 wt%, or 0.2-10 wt%, based on the total weight of the second composition.
Use of kit according to anyone of the preceding claims for caring for keratin materials, especially the skin, for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects.
A process for caring for keratin materials, especially the skin, for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects, comprising the steps of compounding the first composition and the second composition of the kit according to any one of the preceding claims 1-13 at a weight ratio of the first composition to the second composition of from 1: 3 to 1: 20, preferably from 1: 8 to 1: 15, and then applying to a location in need of the thus obtained mixture.