CN106038348A - Antiseptic composition and application thereof in cosmetics - Google Patents
Antiseptic composition and application thereof in cosmetics Download PDFInfo
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- CN106038348A CN106038348A CN201610526037.7A CN201610526037A CN106038348A CN 106038348 A CN106038348 A CN 106038348A CN 201610526037 A CN201610526037 A CN 201610526037A CN 106038348 A CN106038348 A CN 106038348A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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Abstract
The invention relates to an antiseptic composition, comprising the components in percent by weight: 1.0-10% of an antiseptic combination. 10.0-80.0% of propylene glycol and 0.1-0.5% of pH regulator; the antiseptic combination is a mixture of two or more of gluconolactone, sodium benzoate, benzoic acid, sodium dehydroacetate, dehydroacetic acid, sorbitol octoate, levulinic acid, sodium levulinate, sodium p-methoxybenzoate and caprylin. The invention also relates to application of the antiseptic composition in cosmetics. As components of the antiseptic composition are from natural plants, the composition conforms to the European Union requirement and standard for 'ecology' certification, has significant wide-spectrum antibacterial effect, may replace chemical-composition antiseptics, may effectively inhibit gram-positive and gram-negative bacteria, Saccharomyces cerevisiae and molds, is mild and nonirritating, can prevent allergy after use and is higher in product safety.
Description
Technical field
The present invention relates to a kind of compositions with preservative efficacy, specifically, be a kind of combination with preservative efficacy
Thing and the application in cosmetics thereof.
Background technology
Containing abundant nutrient substance in cosmetics, it it is the environment depended on for existence of microorganism.Therefore cosmetics are the most micro-
Biological pollution, makes product muddy, precipitation and color change occur, and the acid product that microbial metabolism generates also can change product
The acid-base value of product, the gas of generation also can cause product foaming, send out and rise, affect outward appearance and the abnormal smells from the patient of product, even produce toxin,
Cause user skin allergy, even result in skin infection.
Just because of this, in order to ensure the Quality Safety of cosmetics, microorganism is suppressed to pollute mainly by adding preservative.So
And, current most cosmetics company the most all can select to add the preservative of chemosynthesis, and chemosynthesis is anti-
There is the risk of zest and bio-toxicity in rotten agent, safety aspect is not the most satisfactory.And along with traditional preservatives
The assessment severization of pressure from public opinion and security legislation, the safety issue that preservative uses at cosmetics increasingly receives publicity.
In recent years, the new product with natural, gentle, green, biodegradable, safety, low emission, environmental friendliness as demand
Issue amount rises year by year.Natural and the cosmetic that organises has become as the core of Europe and North America nursing market, in the one of France
Item investigation display, the consumer of 37% is currently in use natural and organic products, and has and buy natural organic cosmetic purpose
Consumer is up to 87%, and this market trend is being increasingly turned to Asia.
As can be seen here, it is the most necessary that the anticorrosive composite of exploitation new type of safe substitutes chemosynthesis preservative, meets
Market and the urgent needs of consumer.
Summary of the invention
The first object of the present invention is the risk in order to overcome chemosynthesis preservative to cause, it is provided that one has anticorrosion merit
The compositions of effect.
The second object of the present invention has the application in cosmetics of the compositions of preservative efficacy described in being to provide.
For solving above-mentioned technical problem, the present invention adopts the following technical scheme that
A kind of compositions with preservative efficacy, it includes following mass percent component:
Preservative compositions 1.0～10.0%
Propylene glycol 10.0～80.0%
PH adjusting agent 0.1～0.5%.
Preferably, described a kind of compositions with preservative efficacy, it includes following mass percent component:
Preservative compositions 3.0～8.0%
Propylene glycol 10.0～60.0%
PH adjusting agent 0.1～0.5%.
Preferably, described a kind of compositions with preservative efficacy, it includes following mass percent component:
Preservative compositions 5.0～8.0%
Propylene glycol 10.0～50.0%
PH adjusting agent 0.2～0.5%.
Described preservative compositions is that gluconolactone, sodium benzoate, benzoic acid, dehydroactic acid sodium, dehydroactic acid, Pyrusussuriensis are smooth pungent
Acid esters, levulic acid, levulic acid sodium, p-Methoxybenzoic acid are received, two or more mixing in glycerol caprylate.
Described pH adjusting agent is citric acid or sodium citrate.
In the formula of the described compositions with preservative efficacy, surplus is mainly deionized water, can also add institute simultaneously
Other active component needed.
The described compositions with preservative efficacy may be used in cosmetics, addition be by percentage to the quality 0.1～
5.0%, described State of cosmetics can be solution, emulsion, paste, suspension, spraying, gel, facial film, shampoo and wash one's face
Milk etc..
Preferably, described in there is the compositions of preservative efficacy may be used in cosmetics, addition is by percentage to the quality
It is 1.0～3.0%.
Compared with prior art, there is advantages that
The preservative compositions of the present invention is compared with existing preservative, and its composition is for non-chemically to synthesize, and 100% is European Union
The natural botanical source composition of ECOCERT international ecological certification, not only has significant broad-spectrum antibacterial effect, can replace chemistry conjunction
Become the consumption of preservative, can effectively suppress gram positive bacteria, negative bacterium, yeast and mycete, and gentleness does not stimulates, it is to avoid
After using sensitive, improve the safety of product.
The formula of the compositions with preservative efficacy of the present invention does not add artificial flavors, pigment and petrochemistry thing
The composition disadvantageous to skin such as matter, the cosmetic property prepared is stable, and favorable anti-corrosion effect is non-stimulated, meets European Union ecological
The requirement of certification and standard.
What deserves to be explained is, ECOCERT mechanism uses harsh quality examination and authentication procedure, makes any to post its certification
The product of mark all becomes a kind of high-quality and the guarantee of high credit worthiness, is approved by pursuing environmental protection organically whole world personage and pushes away
High.ECOCERT is very popular in personal care articles market, Asia at present, and has been widely recognized.
Specific embodiment
In order to preferably illustrate present invention, illustrate with some preferably specific embodiments below.But these tools
Body embodiment is simply to illustrate that present disclosure rather than limit present invention.
Embodiment 1
A kind of compositions with preservative efficacy, is made up (i.e. by reagent 1 of the mass percent component in formula as below table
Combine with reagent 2):
Preparation method is as follows:
(1) benzoic acid is joined in propylene glycol, at a temperature of 80 DEG C, be heated with stirring to dissolve completely, be cooled to room temperature
Adding the smooth caprylate of Pyrusussuriensis, stirring to mix homogeneously prepares reagent 1；
(2) being pre-configured with the citric acid solution that mass fraction is 10%, add dehydroactic acid sodium, stirring is made completely to dissolving
Obtain reagent 2；
(3) reagent 1 and reagent 2 are stirred to mix homogeneously.
Embodiment 2
A kind of compositions with preservative efficacy, is made up of the mass percent component in formula as below table:
| Composition | Mass percent (%) |
| Water | Surplus |
| Sodium citrate | 0.04 |
| Gluconolactone | 4.0 |
| Propylene glycol | 30.0 |
| Sodium anisate | 0.5 |
| Sodium benzoate | 0.5 |
| Dehydroactic acid sodium | 0.5 |
| Levulic acid sodium | 0.5 |
| Citric acid | 0.3 |
Preparation method is as follows:
Configuration quality mark is the sodium citrate solution of 10%, adds gluconolactone, and stirring is to dissolving completely；Respectively will
Sodium anisate, sodium benzoate, dehydroactic acid sodium and levulic acid sodium put in water, are heated to 80 DEG C of stirrings to dissolving
Completely, add citric acid after being cooled to room temperature to be uniformly dissolved；By the solution configured by above step and mixed with propylene glycol, stirring
To being uniformly dissolved.
Embodiment 3
A kind of compositions with preservative efficacy, is made up (i.e. by reagent 3 of the mass percent component in formula as below table
Combine with reagent 4):
Preparation method is as follows:
(1) glycerol caprylate is joined in propylene glycol, at a temperature of 80 DEG C, be heated with stirring to dissolve completely, be cooled to
Room temperature adds the smooth caprylate of Pyrusussuriensis, and stirring to mix homogeneously prepares reagent 3；
(2) it is pre-configured with the citric acid solution that mass fraction is 10%, adds dehydroactic acid sodium and p-Methoxybenzoic acid
Sodium, stirring prepares reagent 4 completely to dissolving；
(3) reagent 3 and reagent 4 are stirred to mix homogeneously.
Comparative example 1
Use have wide range of applications at present to hydroxyl preservative methyl hydroxybenzoate and propylparaben as a comparison case, its
Anticorrosive composite is made up of the mass percent component in formula as below table:
| Composition | Mass percent (%) |
| Methyl hydroxybenzoate | 4.0 |
| Propylene glycol | 30.0 |
| Propylparaben | 2.0 |
| Water | Surplus |
Preparation method is as follows:
Methyl hydroxybenzoate and propylparaben are added in propylene glycol, at a temperature of 80 DEG C, are heated with stirring to dissolve completely,
After being cooled to room temperature, it is added to the water stirring to mix homogeneously.
Comparative example 2
Use the Bis(hydroxymethyl)imidazolidinyl urea of the Germall series having wide range of applications at present as a comparison case, its
Anticorrosive composite is made up of the mass percent component in formula as below table:
| Composition | Mass percent (%) |
| Bis(hydroxymethyl)imidazolidinyl urea | 6.00 |
| Propylene glycol | 30.0 |
| Water | Surplus |
Preparation method is as follows:
Being added by Bis(hydroxymethyl)imidazolidinyl urea in propylene glycol, stirring, to dissolving completely, adds and stirs in water to mixed
Close uniformly.
Comparative example 1～2 contrasts with the fungistatic effect of embodiment 1～3
Prepared by bacterium solution: each extracting waste candida mycoderma, escherichia coli, staphylococcus aureus, bacillus pyocyaneus, aspergillus niger new
Fresh slant culture is prepared as each bacterium solution, then ratio is turbid, general 0.5 the Maxwell unit of each bacterial concentration (be equivalent to 1.5 ×
108CFU/mL)。
Described Candida albicans (ATCC10231), escherichia coli (ATCC8739), staphylococcus aureus
(ATCC6538), bacillus pyocyaneus (ATCC9027), aspergillus niger (ATCC16404) are commercial.
Using the anticorrosive composite of comparative example 1～2 and embodiment 1～3 as antibacterial, parallel antibacterial by 5 kinds of bacterial strains 3
Circle test: poured into by the nutrient agar after sterilizing 15～20mL in sterile petri dish, injects 0.1mL after cooled and solidified
Above-mentioned bacterium solution, smears with aseptic triangular glass rod and is uniformly expanded to media surface, direct in media surface with sterile working
Equidistant vertically put Oxford cup, pressurize gently so that it is contact tight with culture medium, cup is separately added into the reality of 0.1mL
Execute example 1～3 and comparative example 1～2, each sample do 3 parallel, simultaneously with normal saline do synchronization bacteriostatic experiment carry out blank right
According to, to place corresponding incubator cultivation antibacterial and cultivate 48 hours at 37 DEG C, fungus is cultivated 3～5 days at 28 DEG C.Observe knot on time
Really, measuring the diameter taking inhibition zone with a yardstick, take its meansigma methods, result is as shown in the table:
Result shows: the antibacterial circle diameter of embodiment 1～3 all long than comparative example 1 and comparative example 2, i.e. embodiment 1～3
Fungistatic effect the most notable；And at gram positive bacteria, negative bacterium, yeast and the antibacterial circle diameter of mycotic culture flat board
Length is all at more than 20mm, and diameter length is average, i.e. the fungistatic effect of embodiment 1～3 has significant wide spectrum
Property.
It addition, the present invention has also investigated the zest of these 5 kinds of antibacterial, tested by chick chorioallantoic membrane blood vessel
Card, quantifies zest according to the reaction of blood vessel, embodies the human body skin reaction to stimulating objectively.Test utilizes CAM (i.e. to incubate
The fertilization Embryo Gallus domesticus allantocherion in mid-term in the 10-14 days embryo ages changed) feature that blood vessel is complete, obvious and transparent, respectively will dilution
5 kinds of antibacterial of 100 times and 5 CAM contacts, observe CAM blood vessel injury, comment its degree of injury after effect a period of time
Point, the most serious score value of blood vessel injury is the biggest.Criterion is as shown in the table:
5 kinds of antibacterial are as shown in the table to chick chorioallantoic membrane vascular stimulation result of the test:
| Test sample | Mark | Evaluate |
| Comparative example 1 | 2 | Irritability stimulates: blood vessel has congested phenomenon |
| Comparative example 2 | 3 | Minimal irritation: mild bleeding lesions occurs in blood vessel |
| Embodiment 1 | 0 | Irritability stimulates: CAM is normal, and damage does not occurs in blood vessel |
| Embodiment 2 | 0 | Irritability stimulates: CAM is normal, and damage does not occurs in blood vessel |
| Embodiment 3 | 0 | Irritability stimulates: CAM is normal, and damage does not occurs in blood vessel |
Result shows: the chick chorioallantoic membrane vascular stimulation test of embodiment 1～3 is just presenting irritability stimulation, CAM
Often, blood vessel do not occur damage, illustrate that the zest of embodiment 1～3 is low, safety is high.
Embodiment 4
A kind of facial mask liquid with preservative efficacy, is made up of the mass percent component in formula as below table:
Preparation method is as follows:
(1) B phase is disperseed standby in advance；
(2) the most finely dispersed B phase in the component of A phase and step (1) is put into emulsifying pot jointly, is heated to 80 DEG C,
Stirring and dissolving is lowered the temperature after fully transparent；
(3) treat that temperature is down to 45 DEG C, the active matter of C phase and the compositions with preservative efficacy of embodiment 2 are added breast
Changing pot, stirring and dissolving is to mix homogeneously；
(4) treating that temperature is down to 38 DEG C, discharging, fill is sealed up for safekeeping.
Comparative example 3
A kind of common facial mask liquid with preservative efficacy, is made up of the weight/mass percentage composition component in formula as below table:
Preparation method is as follows:
(1) B phase is disperseed standby in advance；
(2) the most finely dispersed B phase in the component of A phase and step (1) is put into emulsifying pot jointly, is heated to 80 DEG C,
Stirring and dissolving is lowered the temperature after fully transparent；
(3) treat that temperature is down to 45 DEG C, active matter and the conventional preservatives compositions of C phase are added emulsifying pot, stirring and dissolving
To mix homogeneously；
(4) treating that temperature is down to 38 DEG C, discharging, fill is sealed up for safekeeping.
Embodiment 5
A kind of emulsion with preservative efficacy, is made up of the weight/mass percentage composition component in formula as below table:
Wherein, described Butyrospermum parkii fruit fat can select the cattle that responsible company of Bai Chuan bio tech ltd, Xi'an produces
Oil fruit tree fruit fat.Described carbonic acid dibutyl ester can be chosen from Shanghai Ju Hao Fine Chemical Co., Ltd.
Preparation method is as follows:
(1) C phase is uniformly dispersed in advance, stand-by；
(2) component of A phase being put into oil phase pot, be heated to 80 DEG C, stirring is to being completely dissolved；
(3) component of B phase being put into emulsifying pot, be heated to 80 DEG C, stirring and dissolving is to fully transparent；
(4) temperature making emulsifying pot maintains 80 DEG C, controls the mixing speed still state of vacuum at 300r/min, slowly
Suction A phase；
(5) after exhausting, controlling homogenizing speed is 3000r/min, continues emulsifying 10min under the conditions of 80 DEG C；
(6) again the component of C phase is put into emulsifying pot, keep vacuum state, stir under the conditions of 400r/min, fall
Temperature；
(7) treating that temperature is down to 50 DEG C, the component of D phase adds emulsifying pot, stirring is to mix homogeneously；
(8) treating that temperature is down to 38 DEG C, discharging, fill is sealed up for safekeeping.
Embodiment 6
A kind of facial milk cleanser with preservative efficacy, is made up of the weight/mass percentage composition component in formula as below table:
Preparation method is as follows:
(1) C phase is uniformly dispersed in advance, stand-by；
(2) component of A phase being put into oil phase pot, be heated to 80 DEG C, stirring is to being completely dissolved；
(3) component of B phase being put into emulsifying pot, be heated to 80 DEG C, stirring and dissolving is to fully transparent；
(4) temperature making emulsifying pot maintains 80 DEG C, controls the mixing speed still state of vacuum at 300r/min, slowly
Suction A phase, is incubated 80 DEG C and continues emulsifying 20min；
(5) treating that temperature is down to 60 DEG C, the component of C phase is put into emulsifying pot, mixing speed controls at 400r/min, and stirring is extremely
Mix homogeneously；
(6) treat that temperature is down to 50 DEG C, the component of D phase is added emulsifying pot, continuously stirred and continue cooling；
(7) treating that temperature is down to 38 DEG C, discharging, fill is sealed up for safekeeping.
Checking test one: preservation challenge is tested
The preservative compositions of the present invention is the comparison of (facial mask liquid, emulsion, facial milk cleanser) in different systems, weighs many parts of equivalent and treats
Test sample product, the interpolation common facial mask liquid of comparative example 3, embodiment 4 have the facial mask liquid of compositions of preservative efficacy, embodiment 5 respectively
Have the emulsion of the compositions of preservative efficacy, embodiment 6 has the facial milk cleanser of compositions of preservative efficacy, carries out the anticorrosion of 28 days
Challenge test.
Described preservation challenge test reference " preservative challenge testing of cosmetic formulations product ", CTFA microorganism instruction tries
Test.
Prepared by bacterium solution: each extracting waste candida mycoderma, escherichia coli, staphylococcus aureus, bacillus pyocyaneus, aspergillus niger new
Fresh slant culture is prepared as each bacterium solution, then surveys its concentration, and each bacterial concentration reaches 107-108CFU/mL.
Described Candida albicans (ATCC10231), escherichia coli (ATCC8739), staphylococcus aureus
(ATCC6538), bacillus pyocyaneus (ATCC9027), aspergillus niger (ATCC16404) are commercial.
Once add 28 days preservative challenge testing methods of bacterium: weigh each given the test agent 20g, add 0.2mL mixed cell bacterium respectively
Suspension and mixed fungus bacteria suspension, making by the final bacteria containing amount of sample product is 10 respectively6CFU/g (mL) antibacterial and 105CFU/g(mL)
Fungus, stirs.After connecing bacterium the 3rd, 7,14,21 and 28 days are sampled analyzing the bacteria containing amount in sample.
Result is as shown in the table；
Result shows, tests through the preservation challenge of 28 days, with the addition of the face that embodiment 4 has the compositions of preservative efficacy
Film liquid, embodiment 5 have the emulsion of compositions of preservative efficacy, embodiment 6 has the facial milk cleanser of compositions of preservative efficacy
The results of preservation challenge tests of testing sample is the most qualified, illustrates that the present invention has good antiseptic power.
Checking test two: skin irritation is tested
With 60 women as object, take in the coyote hole that 0.03mL sample is placed in speckle examination adhesive tape with syringe, will be equipped with immediately
The speckle examination adhesive tape of sample starts from bottom to be longitudinally affixed on the normal skin of left forearm, and the lightest pressing room is to drive away sky
Gas, and make trier be uniformly distributed.Labelling is carried out at test position, in order to observe.Within each 24 hours, paste skin once, after opening paster
Half an hour, then checked according to the term of CTFA guide (1981).Having carried out 6 patch experiments altogether, speckle skin terminates
After the 6th day, in order to observe late response, carried out additional inspection.Data then utilize last inspection result to be compared
Relatively, identify with following table and carry out for standard:
| Grade | Symbol | Standard of perfection |
| 0 | - | Negative reaction: non-stimulated, without erythema |
| 1 | ± | Suspicious reaction: slight erythema |
| 2 | + | Weak positive reaction: erythema |
| 3 | ++ | Strong positive reaction: erythema, pimple, vesicle |
| 4 | +++ | Extremely strong positive reaction: serious edema, bulla |
Test substances is to add the facial film that the common facial mask liquid of comparative example 3, embodiment 4 have the compositions of preservative efficacy respectively
Liquid, embodiment 5 have the emulsion of compositions of preservative efficacy, embodiment 6 has the treating of facial milk cleanser of compositions of preservative efficacy
Test sample product, test result is as shown in the table:
| Lagging number of times | Comparative example 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
| 1 | 0 | 0 | 0 | 0 |
| 2 | 0 | 0 | 0 | 0 |
| 3 | 0 | 0 | 0 | 0 |
| 4 | 1 time ± | 0 | 0 | 0 |
| 5 | 1 time ± | 0 | 0 | 0 |
| 6 | 1 time ± | 0 | 0 | 0 |
| After end the 6th day | 1 time ± | 0 | 0 | 0 |
| Add up to | 4 times ± | 0 | 0 | 0 |
Result shows, the embodiment of the present invention 4 has the facial mask liquid of compositions of preservative efficacy, embodiment 5 has anti-in interpolation
The testing sample of the facial milk cleanser that the rotten emulsion of compositions of effect, embodiment 6 have the compositions of preservative efficacy compares comparative example 3
The mildness of the common facial mask liquid containing conventional preservatives compositions is more preferable.
It should be noted that " comparative example 1 anticorrosive composite " in comparative example 3 is replaced to " comparative example 2 anticorrosion by the present invention
Compositions " carry out checking test one and checking test two, still obtain that " embodiment of the present invention 4 has the compositions of preservative efficacy
Facial mask liquid, embodiment 5 has the emulsion of compositions of preservative efficacy, embodiment 6 has the face cleaning of compositions of preservative efficacy
It is more preferable that the testing sample of breast compares the mildness of the common facial mask liquid containing conventional preservatives compositions " result.I.e. show this
The compositions fungistatic effect that invention has preservative efficacy is notable, gentle, non-stimulated, and traditional chemical can be replaced completely to synthesize anticorrosion
Agent, the suitability is wide, all can add use in the cosmetics of different dosage form.
What deserves to be explained is, the formula material of the present invention all can buy in market.Unless stated otherwise, in the present invention
The content recorded is weight/mass percentage composition.The experimental technique of unreceipted actual conditions in the present invention, generally according to normal condition,
Or condition recommended by the manufacturer is carried out.
Shown by test, the preservative compositions of the present invention in addition to component compatibility relation disclosed in embodiment 1～3, other
Disclosed component compatibility is not had to have similar effect yet, although the proportioning of each component is the poorest to effect existence of cosmetics
Different, but can effectively suppress gram positive bacteria, negative bacterium, yeast and mycete, and also gentleness does not stimulates, it is to avoid after use
Sensitivity, improves the safety of product.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment
Limit, the change made under other any spirit without departing from the present invention and principle, modify, substitute, combine, simplify,
All should be equivalent replacement mode, within being included in protection scope of the present invention.
Claims (7)
1. a compositions with preservative efficacy, it is characterised in that it includes following mass percent component:
Preservative compositions 1.0～10.0%
Propylene glycol 10.0～80.0%
PH adjusting agent 0.1～0.5%.
A kind of compositions with preservative efficacy the most according to claim 1, it is characterised in that it includes following quality hundred
Proportion by subtraction component:
Preservative compositions 3.0～8.0%
Propylene glycol 10.0～60.0%
PH adjusting agent 0.1～0.5%.
A kind of compositions with preservative efficacy the most according to claim 1, it is characterised in that it includes following quality hundred
Proportion by subtraction component:
Preservative compositions 5.0～8.0%
Propylene glycol 10.0～50.0%
PH adjusting agent 0.2～0.5%.
4. according to the arbitrary described a kind of compositions with preservative efficacy of claim 1-3, it is characterised in that: described anticorrosion group
It is combined into gluconolactone, sodium benzoate, benzoic acid, dehydroactic acid sodium, dehydroactic acid, the smooth caprylate of Pyrusussuriensis, levulic acid, acetyl
Sodium propionate, p-Methoxybenzoic acid are received, two or more mixing in glycerol caprylate.
5. according to the arbitrary described a kind of compositions with preservative efficacy of claim 1-3, it is characterised in that: described pH regulator
Agent is citric acid or sodium citrate.
6. according to the arbitrary described a kind of compositions with preservative efficacy of claim 1-3, it is characterised in that: it is used for making up
Product, addition is 0.1～5.0% by percentage to the quality.
7. according to the arbitrary described a kind of compositions with preservative efficacy of claim 1-3, it is characterised in that: it is used for making up
Product, addition is 1.0～3.0% by percentage to the quality.
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| CN108078859A (en) * | 2018-01-23 | 2018-05-29 | 威莱(广州)日用品有限公司 | A kind of babywipe and preparation method thereof |
| CN108852887A (en) * | 2018-08-02 | 2018-11-23 | 高宝化妆品（中国）有限公司 | A kind of natural anticorrosive composite and its application |
| CN109925207A (en) * | 2019-01-02 | 2019-06-25 | 杭州犇鑫科技有限公司 | A kind of new food preservative composition and its preparation method and application |
| CN111246835A (en) * | 2017-10-27 | 2020-06-05 | 荷兰联合利华有限公司 | Non-soap liquid cleanser compositions comprising caprylic acid |
| CN114376933A (en) * | 2022-01-24 | 2022-04-22 | 抚顺东科新能源科技有限公司 | Antimicrobial composition for infant hand and mouth wet tissue and preparation method thereof |
| CN114795993A (en) * | 2022-02-25 | 2022-07-29 | 上海弗艾柏生物科技有限公司 | Antibacterial and antiseptic composition for pet oral cleaning product and application thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11607377B2 (en) | 2017-10-17 | 2023-03-21 | Conopco, Inc. | Non-soap liquid cleanser composition comprising caprylic acid |
| CN111246835A (en) * | 2017-10-27 | 2020-06-05 | 荷兰联合利华有限公司 | Non-soap liquid cleanser compositions comprising caprylic acid |
| CN111246835B (en) * | 2017-10-27 | 2024-01-02 | 联合利华知识产权控股有限公司 | Non-soap liquid detergent compositions comprising caprylic acid |
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| CN108852887A (en) * | 2018-08-02 | 2018-11-23 | 高宝化妆品（中国）有限公司 | A kind of natural anticorrosive composite and its application |
| CN109925207A (en) * | 2019-01-02 | 2019-06-25 | 杭州犇鑫科技有限公司 | A kind of new food preservative composition and its preparation method and application |
| CN114376933A (en) * | 2022-01-24 | 2022-04-22 | 抚顺东科新能源科技有限公司 | Antimicrobial composition for infant hand and mouth wet tissue and preparation method thereof |
| CN114795993A (en) * | 2022-02-25 | 2022-07-29 | 上海弗艾柏生物科技有限公司 | Antibacterial and antiseptic composition for pet oral cleaning product and application thereof |
| CN114795993B (en) * | 2022-02-25 | 2024-03-19 | 上海弗艾柏生物科技有限公司 | Antibacterial and antiseptic composition for pet oral cleaning product and application thereof |
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