CN103494713B - Composition with antiseptic efficacy and application thereof in cosmetics - Google Patents
Composition with antiseptic efficacy and application thereof in cosmetics Download PDFInfo
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- CN103494713B CN103494713B CN201310482008.1A CN201310482008A CN103494713B CN 103494713 B CN103494713 B CN 103494713B CN 201310482008 A CN201310482008 A CN 201310482008A CN 103494713 B CN103494713 B CN 103494713B
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Abstract
The invention discloses a composition with antiseptic efficacy. The composition is characterized by being composed of, by weight, 10-80% of 1,2-octandiol, 10-80% of 1,2-hexanediol and 1-30% of potentiating agent, the potentiating agent in the composition is one or multiple of tropolone, ethylhexylglycerin, 1,2-propandediol, 1,3-butanediol and 1,2-pentanediol. A preparation method of the composition includes mixing 1,2-octandiol, 1,2-hexanediol and the potentiating agent, stirring for uniformly dissolving, and obtaining the composition. The composition has good antiseptic effect, and utilized raw materials are all safe and nonirritant compounds and are free of damage to human skin, so that the defect that existing antiseptic is serious in damage to the human skin is overcome. In addition, polyalcohol in the composition has good moisturizing efficacy.
Description
Technical field
The present invention relates to a kind of anticorrosive composite and application, a kind of specifically have the glycol composition of preservative efficacy and the application in cosmetics.
Background technology
Containing abundant nutrient pledge in cosmetics, be particularly suitable for growth of microorganism, so need in cosmetics to add antiseptic.The object adding antiseptic at cosmetics is exactly to suppress growth of microorganism and generation, avoids cosmetics produce denaturalization phenomenon and maintain freshness and lasting effect.
China's cosmetics health planning (2007 editions) defines 67 kinds of antiseptic and use limitation thereof that can use in cosmetics.At present, conventional in cosmetics antiseptic has p-Hydroxybenzoate, imidazolidinyl urea, interior uride, isothiazolone, phenyl phenol etc.These antiseptic have certain injury to human body skin, easily cause skin allergy.So, study and use non-stimulated, that safety is high antiseptic actives to become the focus of cosmetics research.
Summary of the invention
Object of the present invention is just to provide a kind of non-stimulated, glycol composition with preservative efficacy that safety is high.
To achieve the object of the present invention, present invention employs following technical scheme:
There is a compositions for preservative efficacy, it is characterized in that the component comprising following percentage by weight: 1,2-ethohexadiol 10-80%, 1,2-hexanediol 10-80%, synergist 1-30%.
In above-mentioned composition, synergist is one or more in tropolone, Sensiva SC50,1,2-PD, 1,3 butylene glycol, 1,2-pentanediol.
The above-mentioned preparation method with the compositions of preservative efficacy, is characterized in that: by 1,2-ethohexadiol, 1,2-hexanediol, synergist mixing, stirring and dissolving is even.
The second object of the present invention be by above-mentioned there is the compositions of preservative efficacy be used in cosmetics, make stable in properties, cosmetics that antiseptic effect is good.
For realizing the second object of the present invention, present invention employs following technical scheme: by above-mentioned there is the compositions of preservative efficacy be used for preparing cosmetics, it is characterized in that its consumption is 0.02-5%, and preferable amount is 0.1-2% containing the above-mentioned compositions with preservative efficacy in anti-aging cosmetics.
The dosage form of cosmetics is not particularly limited, and can be solution, emulsion, paste, foundation emulsion, spray, facial film etc.
The invention has the beneficial effects as follows: compositions of the present invention has good antiseptic effect, raw material used is all some safety, non-stimulated compound, to human body skin fanout free region, overcomes current antiseptic and injures large defect to human body skin.In addition, the polyhydric alcohol in compositions also has good moisture-keeping efficacy.
Detailed description of the invention
Below by way of specific embodiment, the present invention is further illustrated, but these embodiments are just in order to illustrate, are not limitations of the present invention.
embodiment 1 compositions (I) with preservative efficacy and preparation method thereof
The compositions (I) with preservative efficacy is composed as follows by weight percentage: 1,2-ethohexadiol 40%, 1,2-hexanediol 50%, tropolone 10%.
Preparation method is: by 1,2-ethohexadiol, 1,2-hexanediol, tropolone mixing, stirring and dissolving is even.
embodiment 2
compositions (II) with preservative efficacy and preparation method thereof
The compositions (II) with preservative efficacy is composed as follows by weight percentage: 1,2-ethohexadiol 40%, 1,2-hexanediol 48%, Sensiva SC50 12%.
Preparation method is: by 1,2-ethohexadiol, 1,2-hexanediol, Sensiva SC50 mixing, stirring and dissolving is even.
embodiment 3
compositions (III) with preservative efficacy and preparation method thereof
There is the compositions of preservative efficacy
(III)composed as follows by weight percentage: 1,2-ethohexadiol 45%, 1,2-hexanediol 38%, Sensiva SC50 12%, 1,2-pentanediol 5%.
Preparation method is: by 1,2-ethohexadiol, 1,2-hexanediol, Sensiva SC50, pentanediol mixing, stirring and dissolving is even.
embodiment 4 cold cream frost
Table 1 provides not containing the cold cream frost formula with the compositions of preservative efficacy of the present invention.
Table 1
Preparation method: A phase 80 DEG C dissolves mix homogeneously, B phase 80 DEG C dissolves mix homogeneously, adds B phase before Cyclomethicone emulsifying, and during emulsifying, B is added to A phase also homogenizing 5min, adds C phase also homogenizing 2 minutes, pack after ageing 24h when being cooled to 50 DEG C.
embodiment 5 facial treatment milk
Table 2 provides containing the facial treatment milk formula with the compositions of preservative efficacy of the present invention, and the consumption of each material represents with mass fraction.
Table 2
The preparation method of whitening and skin-protecting breast: by the dimethyl siloxane in formula table, isopropyl palmitate, Miglyol 812, monoglyceride, stearic acid mixing, be heated to 80 DEG C, fusing stirs, as oil phase; By the 1,2-PD in formula table, the compositions (II) with preservative efficacy, triethanolamine, deionized water mixing, be heated to 85 DEG C, stirring and dissolving is even, as aqueous phase.Oil phase and aqueous phase are added in emulsifying pot, stir, emulsifying homogeneous, after 6 minutes, when stirring is cooled to 50 DEG C, adds essence, stirs, be cooled to 38 DEG C.
the preparation of embodiment 6 surfactant
Table 3 provides containing the surfactant formula with the compositions of preservative efficacy of the present invention, and the consumption of each material represents with mass fraction.
Table 3
Preparation method: deionized water is heated to 85 DEG C, adds hydroxyethyl-cellulose, stirring and dissolving is even, adds 1,2-PD.When stirring is cooled to 50 DEG C, add other compositions, continue stirring and be cooled to 38 DEG C.
the common surfactant of comparative example 1
Table 4 provides the common surfactant formula not containing compositions of the present invention, and the consumption of each material represents with mass fraction.
Table 4
Preparation method: deionized water is heated to 85 DEG C, adds hydroxyethyl-cellulose, stirring and dissolving is even, adds 1,2-PD.When stirring is cooled to 50 DEG C, add other compositions, continue stirring and be cooled to 38 DEG C.
experimental example 1 skin irritation evaluation experimental
With 40 women and 10 male for object, getting 30mg sample is placed in the coyote hole of speckle examination adhesive tape, longitudinally be affixed on the normal skin of left forearm by the speckle examination adhesive tape being equipped with sample from bottom immediately, light pressing room, to drive away air, and makes trier be uniformly distributed one by one simultaneously.Labelling is carried out, to observe in test position.Pasted skin once every 24 hours, open half an hour after paster, then check according to the term of CTFA guide (1981).Carrying out 6 patch experiments altogether, the 6th day after subsides skin terminates, in order to observe late response, having carried out additional inspection.Data then utilize last check result, compare.Identify with table 5 as standard is carried out.Substances is respectively the surfactant of embodiment 6 and the common surfactant of comparative example 1, and result is as shown in table 6.
Table 5
| Grade | Symbol | Standard of perfection |
| 0 | - | Negative reaction: non-stimulated, without erythema |
| 1 | ± | Suspicious reaction: slight erythema |
| 2 | + | Weak positive reaction: erythema |
| 3 | ++ | Strong positive reaction: erythema, pimple, vesicle |
| 4 | +++ | Extremely strong positive reaction: serious edema, bulla |
Table 6
| Lagging number of times | Comparative example 1 | Blank experiment | Embodiment 1 |
| 1 | 1 time ± | 0 | 0 |
| 2 | 1 time+ | 0 | 0 |
| 3 | 0 | 0 | |
| 4 | 1 time ± | 0 | 0 |
| 5 | 0 | 0 | |
| 6 | 0 | 0 | |
| Terminate latter 6th day | 1 time ± | 0 | 0 |
| Add up to | 3 times ±, 1 time+ | 0 | 0 |
By this result of the test, can recognize that blank experiment is non-stimulated, the surfactant of embodiment 6 is to the stimulation of skin, and the irritant reaction of common surfactant to skin of comparative example 1 still exists.Illustrate that cosmetics zest prepared by the cosmetics ratio common preservatives adopting the compositions with preservative efficacy of the present invention to prepare is little, safer.
experimental example 2 preservation challenge evaluation experimental
1, experimental strain
Staphylococcus aureus ATCC 6538(staphylococcus aureus)
Escherichia coli ATCC 8739 (escherichia coli)
Pseudomonas aeruginosa ATCC 9027 (bacillus pyocyaneus)
Candida albicans ATCC 10231 (candida albicans)
Aspergillus niger ATCC 9029 (Aspergillus niger)
2, the keeping of experimental strain and condition of culture
(1) antibacterial and candida albicans
Culture medium: TSB
Maintaining requirement: cold preservation 4 ~ 8 DEG C
Maintaining requirement: 2 months
(2) Aspergillus niger
Culture medium: PDB
Maintaining requirement: cold preservation 4 ~ 8 DEG C
Maintaining requirement: 2 months
3, test bacterium liquid manufacture method
(1) (test portion every gram of experiment is 10 to antibacterial liquid manufacture method
7cfu)
Three kinds of antibacterials and Candida albicans are respectively got 50 μ L and are added and inoculate in the 5mL TSB culture fluid of sterilization treatment, then cultivate 48 hours at 37 DEG C of shaking tables, obtain the bacterium liquid of each bacterium.According to 10
6, 10
7, 10
8three dilution factor LB culture medium are cultivated, and then confirm the viable count of each bacterium liquid.Each bacterium liquid is got in the 50mL centrifuge tube that 1mL is added to and is mixed, and (concentration of mixed bacteria liquid is for preferably to control 1.0 × 10 to obtain mixed bacteria liquid
9about cfu/mL).
(2) (test portion every gram of experiment is 10 to the manufacture method of fungus liquid
5cfu)
Reference culture bacterium (Aspergillus niger) is inoculated in culture medium, then after cultivating spore fully inside the incubator being placed on 25 DEG C, be inoculated in culture fluid PDB10mL by the spore platinum inoculating loop of cultured black, fully spore evenly, then scrapes off by concussion inside culture medium.After the spore scraped off and fluid medium fully being mixed, the bacterium liquid got above is collected in centrifuge tube, obtains fungus liquid.By fungus liquid (about 10
7cfu) be diluted on PDA after cultivation as far as possible, confirm the bacterium number of survival.
4, experimental technique
(1) antibacterial preservative challenge test method
1. inside 50mL centrifuge tube test portion 20g being placed on sterilizing.
2. the test portion every gram 10 of the antibacterial liquid made
9cfu and 200 μ L is inoculated in test portion and mixes uniformly.
3. the bacterium liquid mixed is put into inside the culture medium of 35 DEG C of room temperature, cultivate 4 time-of-weeks then from inoculation day 7,14,28 days after, the several explanation according to experimental technique of the bacterium also survived in test products is tested, and 10 of stock solution times of dilutions is then carried out testing (the 7th day then test by 100 times of dilutions).
(2) aspergillus niger antiseptical experimental technique
1. the 50ml centrifuge tube by sterilizing is placed on inside test portion 20g.
2. the test portion every gram 10 of the fungus liquid made
7cfu and 200 μ L is inoculated in test portion and mixes uniformly
3. carrying out the cultivation of 60 days inside the culture medium bacterium liquid mixed being put into room temperature 25 DEG C, was that an interval is confirmed whether whether spoiled and surperficial mycelia has generation with 7 days.Then 10 of stock solution times of dilutions are carried out testing (then testing by 100 times of dilutions when the 7th day)
5, decision method
The antiseptic power of product is evaluated with standard below.
(1) in the 7th day 1 × 10
4it is qualified that the words that cfu/g reduces downwards are just judged to be.
(2) if can determine at 14 days, it is qualified that the words that when 28 days, bacterium number was few than the 7th day are just judged to be.
(3) if the situation listed by table 7 that met in 4 weeks be just judged to be qualified.
Table 7
| Grade(quality) | Antibacterial | Fungus (perusal, whether spoiled) |
| A | Bacterium number < 1 × 10 after 7 days 4 cfu/g | Within 6 weeks, mycete does not generate |
| B | Bacterium number < 1 × 10 after 7 days 5 cfu/g | Within 4 weeks, mycete does not generate |
6, result
The product that embodiment 4,5,6 makes is carried out preservation challenge experiment, the results are shown in Table shown in 8,9,10.
Table 8
| Embodiment 4 | Blank sample contrasts | 0d(once adds bacterium) | 7d | 14d | 21d | 28d |
| Antibacterial | 0 | 3.0×10 7 | 10 | 0 | 0 | 0 |
| Fungus | 0 | 1.0×10 5 | 0 | 0 | 0 | 0 |
Table 9
| Embodiment 5 | Blank sample contrasts | 0d(once adds bacterium) | 7d | 14d | 21d | 28d |
| Antibacterial | 0 | 3.0×10 7 | 0 | 0 | 0 | 0 |
| Fungus | 0 | 1.0×10 5 | 0 | 0 | 0 | 0 |
Table 10
| Embodiment 6 | Blank sample contrasts | 0d(once adds bacterium) | 7d | 14d | 21d | 28d |
| Antibacterial | 0 | 3.0×10 7 | 10 | 0 | 0 | 0 |
| Fungus | 0 | 1.0×10 5 | 0 | 0 | 0 | 0 |
From table 8,9,10, it is qualified that the product that embodiment 4,5,6 makes is preservation challenge experimental result, has stronger antiseptic power.
Claims (3)
1. there is a compositions for preservative efficacy, it is characterized in that composed as follows by weight percentage: 1,2-ethohexadiol 40%, 1,2-hexanediol 48%, Sensiva SC50 12%; Preparation method is: by 1,2-ethohexadiol, 1,2-hexanediol, Sensiva SC50 mixing, stirring and dissolving is even.
2. there is a compositions for preservative efficacy, it is characterized in that composed as follows by weight percentage: 1,2-ethohexadiol 45%, 1,2-hexanediol 38%, Sensiva SC50 12%, 1,2-pentanediol 5%; Preparation method is: by 1,2-ethohexadiol, 1,2-hexanediol, Sensiva SC50, pentanediol mixing, stirring and dissolving is even.
3. the application of the compositions with preservative efficacy in preparing cosmetics described in claim 1, any one of claim 2, is characterized in that its consumption is 0.02-5% containing the above-mentioned compositions with preservative efficacy in cosmetics.
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| CN104586679B (en) * | 2014-12-22 | 2018-08-03 | 广州环亚化妆品科技有限公司 | A kind of face paste film composition and preparation method thereof without preservative |
| CN104644499A (en) * | 2015-01-27 | 2015-05-27 | 广州环亚化妆品科技有限公司 | Composition with powerful preservative effect and application of composition in cosmetics |
| CN104800128B (en) * | 2015-05-06 | 2018-01-23 | 广州神采化妆品有限公司 | A kind of multiple-effect without preservative repairs Essence and preparation method thereof |
| CN107550745A (en) * | 2017-08-31 | 2018-01-09 | 北京明弘科贸有限责任公司 | A kind of anticorrosive composite and its application |
| CN109363962B (en) * | 2018-09-26 | 2022-07-26 | 浙江珂瑞康生物医疗科技有限公司 | Active collagen skin care composition and preparation method thereof |
| EP4161473A4 (en) * | 2020-06-05 | 2024-01-24 | Henkel AG & Co. KGaA | Use of a compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups as a microbiome regulator on scalp |
| CN116196230B (en) * | 2023-03-10 | 2023-11-10 | 广州艾卓生物科技股份有限公司 | Corrosion-resistant composition and application thereof |
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| CN102379821A (en) * | 2010-08-26 | 2012-03-21 | 科丝美诗(中国)化妆品有限公司 | Cosmetic additive and cosmetic |
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| CN102379821A (en) * | 2010-08-26 | 2012-03-21 | 科丝美诗(中国)化妆品有限公司 | Cosmetic additive and cosmetic |
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