CN104644499A - Composition with powerful preservative effect and application of composition in cosmetics - Google Patents
Composition with powerful preservative effect and application of composition in cosmetics Download PDFInfo
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- CN104644499A CN104644499A CN201510042110.9A CN201510042110A CN104644499A CN 104644499 A CN104644499 A CN 104644499A CN 201510042110 A CN201510042110 A CN 201510042110A CN 104644499 A CN104644499 A CN 104644499A
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Abstract
The invention discloses a composition with a powerful preservative effect. The composition comprises the following components in percentage by weight: 10%-70% of 1,2-hexanediol, 5%-10% of 1,2-pentanediol, 5%-10% of sorbitan octoate, 2%-5% of anisic acid, 5%-10% of p-hydroxyacetophenone, 1%-5% of a Chinese herb extract and 5%-30% of a synergist, wherein the Chinese herb extract is combination of a tea extract, a hibiscus mutabilis extract and a liquorice root extract. The invention further discloses an application of the composition with the powerful preservative effect in cosmetics, and the amount is 0.5-5.0%. The composition has the beneficial effects that the all materials are safe and non-stimulant compounds and natural extracts, so that the composition is free of harms to human skin; the defect of harms to the human skin caused by the preservative at present is overcome; and in addition, the polyhydric alcohol, sorbic octanoate and Chinese herbal medicine extracts in the composition also have good skincare efficacy.
Description
Technical field
The invention belongs to cosmetic field, specifically a kind of have the compositions of potent antiseptic effect and the application in cosmetics thereof.
Background technology
Cosmetics are usually containing abundant nutritional labeling, and be particularly suitable for growth of microorganism, the object of adding antiseptic in cosmetics is growth and the generation of anti-bacteria, avoid cosmetics produce denaturalization phenomenon and maintain freshness and lasting effect.
China's " cosmetics health specification (2007 editions) " defines 67 kinds of antiseptic and use limitation thereof that can use in cosmetics.In cosmetics, Common Preservatives mainly comprises: parabens, imidazolidinyl urea, Methylisothiazolinone, methylchloroisothiazandnone, phenoxyethanol etc.Although these antiseptic use amounts are low, there is good antiseptic effect, make cosmetics not by the pollution of microorganism, also potential threat and certain stimulation are brought to skin simultaneously, easily cause skin allergy.
In recent years, all kinds of cosmetics regulations, to using the use amount of antiseptic and service condition all along with the propensity to consume of consumer does corresponding amendment, makes cosmetic personal care's articles for use safer, more secure.Such as December in 2013 12 days, Europe cosmetic personal care's articles for use association has delivered and has stopped using (comprising cosmetic wet tissue) industry of antiseptic Methylisothiazolinone (MIT) to advise about stop class cosmetics, and advises that cosmetics company stops using antiseptic MIT as early as possible in stop class cosmetics.
On January 22nd, 2014, European Union have issued the circular (G/TBT/N/EU/157) of revision cosmetics preservative relevant laws and regulations to the WTO Secretariat, triclosan is deleted by this circular from regulation (EC) No1223/2009 annex V (antiseptic positive list), and limit it and use as cosmetics preservative, also prohibit the antiseptic that 5 kinds do not have security evaluation data simultaneously, be respectively: nipalgin isopropyl ester, oxybenzene isobutyl ester, P-hydroxybenzoic acid phenyl ester, benzyl p-hydroxybenzoate and P-hydroxybenzoic acid.The Proposed date of adoption of this circular regulation is in January, 2014, and Proposed date of entry into force is after European Union official's gazette publication 20 days.
In sum, along with the progress of science and technology, growth in the living standard.Consumer more and more payes attention to skin care, more and more pays close attention to the safety of skin care item, pursues natural skin care.And as can be seen from the use limitation requirement of various regulation to antiseptic and the revision of service condition, although although antiseptic plays preservative efficacy under the effect of pathogenic bacterium, when consumer uses, potential threat and certain stimulation are brought to skin.So consumer throws doubt upon to chemical preservative safety, more and more pursue natural, healthy skin protection, impel cosmetic industry to start to find the alternative route of antiseptic.So, study and use the compositions of non-stimulated, that safety is high potent antiseptic effect to become the focus of cosmetics research.
Summary of the invention
The first object of the present invention, for the present situation of above-mentioned prior art, provides a kind of non-stimulated, compositions with potent antiseptic effect that safety is high.
Another object of the present invention is to provide the application of compositions in cosmetics with potent antiseptic effect, makes stable in properties, favorable anti-corrosion effect, non-stimulated cosmetics.
In order to reach object of the present invention, present invention employs following technical scheme: a kind of compositions with potent antiseptic effect, it is made up of the component comprising following percentage by weight:
Described Chinese herbal medicine extract comprises following weight percent composition:
Folium Camelliae sinensis extract 0.2-3.0%
Flos Hibisci Mutabilis extract 0.2-3.0%
Radix Glycyrrhizae extract 0.2-3.0%.
Described synergist is one or more the combination in glycerol, 1,3 butylene glycol, 1,2-PD or 1,3-PD.
The step that the described manufacture method with the compositions of potent antiseptic effect comprises is as follows: by 1,2-hexanediol, 1, the smooth caprylate of 2-pentanediol, Pyrusussuriensis, anisic acid, parahydroxyacet-ophenone, Chinese herbal medicine extract and synergist mix, and stirring and dissolving evenly.
The described compositions with potent antiseptic effect is the above-mentioned application of compositions in cosmetics with potent antiseptic effect in the second object of the present invention, makes stable in properties, favorable anti-corrosion effect, non-stimulated cosmetics.
The described compositions with potent antiseptic effect is applied to preparing cosmetics, and its use amount is 0.5-5.0%, and preferred use amount is 1.0-3.0%.Especially in moisture-keeping cosmetics, there is excellent effect seemingly.
The described compositions with potent antiseptic effect is for the preparation of cosmetics, and its dosage form be suitable for can be solution, emulsion, paste, suspension, spraying, gel, facial film, shampoo and cleansing milk etc.
Compared with prior art, the invention has the beneficial effects as follows: the compositions of potent antiseptic effect of the present invention is added in conventional cosmetic formulations, can obtain not containing the cosmetics of chemical preservative; Because raw material used in the present invention is all safety, non-stimulated compound, to human body skin fanout free region, overcomes current antiseptic and large shortcoming is injured to human body skin; In addition, the smooth caprylate of the polyhydric alcohol in compositions, Pyrusussuriensis and Chinese herbal medicine also have good skin-care effect.
Detailed description of the invention
Below by way of specific embodiment, invention is further described, further illustrates beneficial effect of the present invention in conjunction with preservation challenge test and Skin Irritation Test.But these embodiments are just in order to illustrate, are not limitations of the present invention.
Embodiment 1
There is the compositions of potent antiseptic effect, be made up of the component of following percentage by weight:
Wherein, described Chinese herbal medicine extract is following weight percent composition:
Folium Camelliae sinensis extract 0.5%
Flos Hibisci Mutabilis extract 1.0%
Radix Glycyrrhizae extract 2.5%.
The above-mentioned preparation method with the compositions of potent antiseptic effect is: by 1,3-butanediol, anisic acid and parahydroxyacet-ophenone are heated to 80 DEG C and dissolve completely, cool to room temperature, add 1 again, 2-hexanediol, 1, the smooth caprylate of 2-pentanediol, Pyrusussuriensis, Chinese herbal medicine extract, stirring and dissolving evenly.
Embodiment 2
There is the compositions of potent antiseptic effect, be made up of the component of following percentage by weight:
Wherein, described Chinese herbal medicine extract is following weight percent composition:
Folium Camelliae sinensis extract 2.5%
Flos Hibisci Mutabilis extract 1.0%
Radix Glycyrrhizae extract 0.5%.
The above-mentioned preparation method with the compositions of potent antiseptic effect is: by 1, ammediol, anisic acid and parahydroxyacet-ophenone are heated to 82 DEG C and dissolve completely, cool to room temperature, add 1 again, 2-hexanediol, 1, the smooth caprylate of 2-pentanediol, Pyrusussuriensis, Chinese herbal medicine extract, stirring and dissolving evenly.
Embodiment 3
There is the compositions of potent antiseptic effect, be made up of the component of following percentage by weight:
Wherein, described Chinese herbal medicine extract is following weight percent composition:
Folium Camelliae sinensis extract 1.5%
Flos Hibisci Mutabilis extract 1.0%
Radix Glycyrrhizae extract 1.5%.
The above-mentioned preparation method with the compositions of potent antiseptic effect is: glycerol, anisic acid and parahydroxyacet-ophenone are heated to 78 DEG C and dissolve completely, cool to room temperature, then add 1,2-hexanediol, 1, the smooth caprylate of 2-pentanediol, Pyrusussuriensis, Chinese herbal medicine extract, stirring and dissolving evenly.
Embodiment 4
There is the compositions of potent antiseptic effect, be made up of the component of following percentage by weight:
Wherein, described Chinese herbal medicine extract is following weight percent composition:
Folium Camelliae sinensis extract 0.3%
Flos Hibisci Mutabilis extract 1.0%
Radix Glycyrrhizae extract 0.7%.
The above-mentioned preparation method with the compositions of potent antiseptic effect is: glycerol, anisic acid and parahydroxyacet-ophenone are heated to 78 DEG C and dissolve completely, cool to room temperature, then add 1,2-hexanediol, 1, the smooth caprylate of 2-pentanediol, Pyrusussuriensis, Chinese herbal medicine extract, stirring and dissolving evenly.
Embodiment 5
There is the compositions of potent antiseptic effect, be made up of the component of following percentage by weight:
Wherein, described Chinese herbal medicine extract is following weight percent composition:
Folium Camelliae sinensis extract 0.3%
Flos Hibisci Mutabilis extract 1.0%
Radix Glycyrrhizae extract 0.7%.
The above-mentioned preparation method with the compositions of potent antiseptic effect is: glycerol, anisic acid and parahydroxyacet-ophenone are heated to 78 DEG C and dissolve completely, cool to room temperature, then add 1,2-hexanediol, 1, the smooth caprylate of 2-pentanediol, Pyrusussuriensis, Chinese herbal medicine extract, stirring and dissolving evenly.
In above-described embodiment, the VelsanSC that the smooth caprylate of described Pyrusussuriensis can select Clariant (China) company limited to produce; The Velsan AS that described anisic acid can select Clariant (China) company limited to produce; The MULTIEX BSASM that described Folium Camelliae sinensis extract selects Ou Site company of Korea S hundred (BIOSPECTRUM) to produce; The flower acid (FLOWER ACIDS) that described Flos Hibisci Mutabilis extract can select French Lv Ke company (GREENTECH) to produce; Described Radix Glycyrrhizae extract can select the LICORICE EXTRACT of Lang De company of Korea S hundred (OLBIAND).
The compositions with potent antiseptic effect of the present invention is applicable to being applied in cosmetics very much, makes stable in properties, favorable anti-corrosion effect, non-stimulated cosmetics; Its use amount is 0.8-4.0%, and preferred use amount is 1.0-3.0%.Especially in moisture-keeping cosmetics, have excellent effect seemingly, its preferred use amount is 2.5%.The described compositions with potent antiseptic effect is for the preparation of cosmetics, and its dosage form be suitable for can be solution, emulsion, paste, suspension, spraying, gel, facial film, shampoo and cleansing milk etc.
Embodiment 6
Containing the facial milk cleanser of compositions with potent antiseptic effect, it is made up of following table component and content:
A kind of step of facial milk cleanser preparation method of the compositions containing having potent antiseptic effect is as follows:
1. be uniformly dispersed C phase in advance, stand-by;
2. A phase component is dropped into oil phase pot and be heated to 80 DEG C, be uniformly mixed, make it dissolve completely transparent, stand-by;
3. B phase component is dropped into emulsifying pot, stirring and dissolving is completely transparent, is heated to 80 DEG C, stand-by;
4. emulsifying pot is incubated 80 DEG C, controls mixing speed in the still state of the vacuum of 300r/min, slowly suction A phase, after exhausting, is incubated 80 DEG C and continues to stir 20min, mix homogeneously;
5. cool to 60 DEG C, the C phase component that will be uniformly dispersed in advance drops into emulsifying pot, and mixing speed controls at 400r/min, stirs 10min, mix homogeneously;
6. cool to 50 DEG C, add D phase component, keep mixing speed at 400r/min, stir 10min, mix homogeneously, continue cooling;
7. cool to 40 DEG C and thermally sensitive composition E phase component and F phase component are added emulsifying pot, vacuum state successively, keep mixing speed at 400r/min, stir;
8. stir, cool to 38 DEG C of dischargings, fill is sealed up for safekeeping.
Embodiment 7
Containing the emulsion of compositions with potent antiseptic effect, it is made up of following table component and content:
Wherein, described Butyrospermum parkii fruit fat Butyrospermum parkii really fat that Xi'an Bai Chuan biotechnology Co., Ltd can be selected to produce.Described dicaprylyl carbonate can be chosen from Shanghai Ju Hao Fine Chemical Co., Ltd.
Above-mentioned kind containing have potent antiseptic effect compositions the preparation method of emulsion as follows:
1. be uniformly dispersed C phase in advance, stand-by;
2. A phase component is dropped into oil phase pot and be heated to 80 DEG C, be uniformly mixed, make it dissolve completely transparent, stand-by;
3. B phase component is dropped into emulsifying pot, stirring and dissolving is completely transparent, is heated to 80 DEG C, stand-by;
4. emulsifying pot is incubated 80 DEG C, controls mixing speed in the still state of the vacuum of 300r/min, slowly suction A phase, and after exhausting, be incubated 80 DEG C and continue emulsifying 10min, speed is at 3000r/min;
5. stop homogenizing and stirring, maintain the temperature at 80 DEG C, C phase component is dropped into emulsifying pot, keep vacuum state, mixing speed controls at 400r/min, stirs 10min, dissolves mix homogeneously;
6. cool to 50 DEG C and thermally sensitive composition D is added to emulsifying pot, vacuum state, keep mixing speed at 400r/min, stir;
7. stir, cool to 38 DEG C of dischargings, fill is sealed up for safekeeping.
Embodiment 8
Containing the facial mask liquid of compositions with potent antiseptic effect, it is made up of following table component and content:
A kind of preparation method of facial mask liquid of the compositions containing having potent antiseptic effect is as follows:
1. B phase is disperseed in advance, stand-by;
2. A phase component is dropped into emulsifying pot, stirring and dissolving is completely transparent, is heated to 80 DEG C, stand-by;
3. emulsifying pot is incubated 80 DEG C, adds B phase, stirs;
4. cool to 50 DEG C and thermally sensitive composition C phase component and D phase component are added emulsifying pot successively, keep mixing speed at 400r/min, stir;
5. stir, cool to 38 DEG C of dischargings, fill is sealed up for safekeeping.
Comparative example 1
Common facial mask liquid, it is made up of following table component and content:
The preparation method of common facial mask liquid is as follows:
1. B phase is disperseed in advance, stand-by;
2. A phase component is dropped into emulsifying pot, stirring and dissolving is completely transparent, is heated to 80 DEG C, stand-by;
3. emulsifying pot is incubated 80 DEG C, adds B phase component, stirs;
4. cool to 50 DEG C and thermally sensitive composition C phase component and D phase component are added emulsifying pot successively, keep mixing speed at 400r/min, stir;
5. stir, cool to 38 DEG C of dischargings, fill is sealed up for safekeeping.
Experiment effect proves
The experiment of experimental example 1 preservation challenge and result
In order to compare the embodiment of the present invention 6, product that embodiment 6, embodiment 7 have potent antiseptic effect compositions and comparative example 1 be containing the antiseptic power of the facial mask liquid of antiseptic, according to the preservation challenge detection method of CTFA, done the preservation challenge experiment of 28 days, what basis for estimation was recommended with CTFA once adds the test of bacterium preservation challenge and evaluation criterion:
(1) experimental strain
Candida albicans (ATCC10231), escherichia coli (ATCC8739), staphylococcus aureus (ATCC6538), bacillus pyocyaneus (ATCC9027), aspergillus niger (ATCC16404) are all purchased from microorganism preservation center, Guangdong Province (Guangdong Microbes Inst).
(2) key instrument equipment, culture medium and reagent
Clean bench (Purifying Equipment Co., Ltd., Suzhou), biochemical cultivation case (Shanghai one permanent tech equipment company limited), mold incubator (Shanghai Medical Equipment Plant of Bo Xun Industrial Co., Ltd.), climatic chamber (executing all triumphant instrument and equipment Shanghai company limited).Lecithin, tween 80 agar culture medium, rose bengal medium, common slant medium, modified lecithin meat soup, normal saline etc.
(3) preservation challenge experimental technique
This laboratory reference cosmetics, toilet articles and fragrance association (CTFA) Microbial Challenge test method be namely: add a certain amount of mixed microorganism bacteria suspension in cosmetics, adds mixed vaccine amount and be respectively: antibacterial 3.0 × 10
7cFU/g (CFU/m1) and mycete 1.0 × 10
5cFU/g (CFU/m1)), mixed sample observes the survival condition of microorganism in special time separation detection: 0 hour (namely sampling at once after inoculation), 7 days, 14 days, 21 days and 28 days results, require that the antibacterial the 7th day time reduces by 99.9%, mycete reduces by 90%; And continuous decrease is zero to judge the antiseptic effect of antiseptic in 28 days, concrete judged result is with reference to following table.
(4) preservation challenge experimental result
The embodiment of the present invention 6, embodiment 7, embodiment 8 have the product of the compositions of potent antiseptic effect and comparative example 1 is as shown in the table containing the preservation challenge result of the facial mask liquid of antiseptic:
Shown in upper table, through the preservation challenge of 28 days, the preservation challenge experimental result that embodiment 6, embodiment 7, embodiment 8 with the addition of the product of the compositions with potent antiseptic effect is all qualified, has good antiseptic power.In addition, test separately with the compositions with potent antiseptic effect, also obtain corresponding effect.
Experimental example 2 skin irritation test
With 60 women for object, getting 0.03ml sample with syringe is placed in the coyote hole of speckle examination adhesive tape, longitudinally be affixed on the normal skin of left forearm by the speckle examination adhesive tape being equipped with sample from bottom immediately, light pressing room, to drive away air, and makes trier be uniformly distributed one by one simultaneously.Labelling is carried out, to observe in test position.Pasted skin once every 24 hours, open half an hour after paster, then check according to the term of CTFA guide (1981).Carrying out 6 patch experiments altogether, the 6th day after subsides skin terminates, in order to observe late response, having carried out additional inspection.Data then utilize last check result, compare.Identify with following table to be that standard is carried out:
Substances is respectively the mastic adding embodiment 6, embodiment 7, embodiment 8 and the comparative example 1 containing antiseptic with the compositions of potent antiseptic effect, and result is as shown in the table:
As shown above, to have the product comparison ratio 1 of the compositions of potent antiseptic effect better containing the mildness of the facial mask liquid of antiseptic for the embodiment of the present invention 6, embodiment 7, embodiment 8.
More than describe preferred embodiment of the present invention in detail, that inventor takes a large amount of talent's financial resources and time, test of many times out result, should be appreciated that the ordinary skill of this area just design according to the present invention can make many modifications and variations without the need to creative work.Therefore, all technical staff in the art according to the present invention's design on prior art basis by logical analysis, reasoning or according to the available technical scheme of limited experiment, all should by among the determined protection domain of these claims.
Claims (8)
1. have a compositions for potent antiseptic effect, it is characterized in that, it is made up of the component comprising following percentage by weight:
2. the compositions with potent antiseptic effect according to claim 1, is characterized in that, described Chinese herbal medicine extract comprises following weight percent composition:
Folium Camelliae sinensis extract 0.2-3.0%
Flos Hibisci Mutabilis extract 0.2-3.0%
Radix Glycyrrhizae extract 0.2-3.0%.
3. the compositions with potent antiseptic effect according to claim 1, is characterized in that, described synergist is one or more the combination in glycerol, 1,3 butylene glycol, 1,2-PD or 1,3-PD.
4. according to the arbitrary described manufacture method with the compositions of potent antiseptic effect of claim 1-3, it is characterized in that, the step comprised is as follows: by 1,2-hexanediol, 1, the smooth caprylate of 2-pentanediol, Pyrusussuriensis, anisic acid, parahydroxyacet-ophenone, Chinese herbal medicine extract and synergist mix, and stirring and dissolving is even.
5. according to the arbitrary described application of the compositions with potent antiseptic effect in cosmetics of claim 1-3.
6. the application of compositions in cosmetics with potent antiseptic effect according to claim 5, it is characterized in that, its use amount is 0.5-5.0%.
7. the application of compositions in cosmetics with potent antiseptic effect according to claim 6, it is characterized in that, use amount is 1.0-3.0%.
8. the application of compositions in cosmetics with potent antiseptic effect according to claim 6, it is characterized in that, dosage form is solution, emulsion, paste, suspension, spraying, gel, facial film, shampoo and cleansing milk.
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| CN107198667A (en) * | 2017-05-19 | 2017-09-26 | 广西汉宝生物科技有限公司 | A kind of new bacteriostatic agent without anti-corrosion concept |
| CN107624758B (en) * | 2017-10-17 | 2020-07-07 | 北京桑普生物化学技术有限公司 | Compound composition containing p-hydroxyacetophenone and preparation method and application thereof |
| CN107624758A (en) * | 2017-10-17 | 2018-01-26 | 北京桑普生物化学技术有限公司 | A kind of complex composition containing parahydroxyacet-ophenone and preparation method and application |
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| CN107802565A (en) * | 2017-12-21 | 2018-03-16 | 李冬梅 | A kind of composite vegetables extractive and its application in cosmetics preservative |
| CN108685802A (en) * | 2018-08-07 | 2018-10-23 | 广东丸美生物技术股份有限公司 | Anticorrosive composite and its preparation method and application |
| CN108685802B (en) * | 2018-08-07 | 2019-10-18 | 广东丸美生物技术股份有限公司 | Anticorrosive composite and its preparation method and application |
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| CN112702914B (en) * | 2018-08-27 | 2024-01-30 | 西姆莱斯股份公司 | Antimicrobial mixtures containing at least one hydroxyacetophenone derivative |
| CN112544620A (en) * | 2020-12-25 | 2021-03-26 | 中国科学院合肥物质科学研究院 | Anticorrosive composition and preparation method thereof |
| CN112544620B (en) * | 2020-12-25 | 2021-10-08 | 中国科学院合肥物质科学研究院 | Anticorrosive composition and preparation method thereof |
| CN117205122A (en) * | 2023-10-13 | 2023-12-12 | 珍卡儿药妆有限公司 | Aqueous antiseptic composition, preparation method and application thereof |
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