CN104983589A - Self-micro-emulsifying liquid of natural plant corrosion prevention and bacterium inhibition liquid and preparing method of self-micro-emulsifying liquid - Google Patents
Self-micro-emulsifying liquid of natural plant corrosion prevention and bacterium inhibition liquid and preparing method of self-micro-emulsifying liquid Download PDFInfo
- Publication number
- CN104983589A CN104983589A CN201510338093.3A CN201510338093A CN104983589A CN 104983589 A CN104983589 A CN 104983589A CN 201510338093 A CN201510338093 A CN 201510338093A CN 104983589 A CN104983589 A CN 104983589A
- Authority
- CN
- China
- Prior art keywords
- self
- oil
- mixture
- parts
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention relates to self-micro-emulsifying liquid of natural plant corrosion prevention and bacterium inhibition liquid and a preparing method of the self-micro-emulsifying liquid. The self-micro-emulsifying liquid is prepared from plant extract, an emulsifying agent, a co- emulsifying agent and pure water. The self-micro-emulsifying liquid of the natural plant corrosion prevention and bacterium inhibition liquid and the preparing method of the self-micro-emulsifying liquid have the advantages that the plant extract is used as the corrosion prevention and bacterium inhibition ingredient, the corrosion prevention and bacterium inhibition functions are achieved, and meanwhile the effects of heath care and skin care are achieved.
Description
Technical field
The invention belongs to cosmetics additive field, be specifically related to that a kind of natural plants is anticorrosion, the self-microemulsifying drug delivery of antibacterial liquid and preparation method thereof.
Background technology
Cosmetics nearly all need to add efficacy active component, but most of efficacy active component is difficult to be absorbed at skin surface, and can efficacy active component be absorbed the important determiner becoming and determine cosmetics quality; In addition; even if cosmetic industry active component can be absorbed by the skin; also need to reach certain amount just effective; and the structure of efficacy active component usually in cosmetics is more complicated; less being difficult to of dissolubility reaches corresponding valid density, and efficacy active component solubilising has become the important technical barrier of this kind of preparation.
Therefore how solution product research and develop the study hotspot that these technical barriers faced in preparation process become cosmetics research staff.
On the other hand, normal containing nutrient substance such as protein, aminoacid, vitamin in cosmetics, the substrate of these nutritional labelings microbial growth such as antibacterial, fungus procreation just.In order to avoid or reduce cosmetics producing and the pollution problem of microorganism in using, often in cosmetics, add antiseptic.
At present, in cosmetics, most antiseptic used mostly is halogen antiseptic, Form aldehyde release class antiseptic, acid antiseptic etc.But along with the development of science and technology, people find that above-mentioned conventional antiseptic often has larger side effect gradually, as p-Hydroxybenzoate can cause contact dermatitis; Triclosan has carcinogenesis, and this causes also often there will be the problem such as toxicity allergy, metabolism of pigment disorder in the use procedure of skin care item in life.
Along with people's living standard improves day by day, the security requirement of skin care item antiseptic is also more and more paid close attention to.Meanwhile, desirably, cosmetics preservative, realizing anticorrosion, antibacterial effect simultaneously, has effect of health-care and skin-care simultaneously, so a kind of safe, natural and antiseptic with health-care and skin-care effect is urgently developed.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides that a kind of natural plants is anticorrosion, the self-microemulsifying drug delivery of antibacterial liquid and preparation method thereof.The present invention can solve the problem that in cosmetics, efficacy active component dissolubility is low, bioavailability is low, and provides a kind of safe, natural and have the antiseptic of health-care and skin-care effect.
The technical solution adopted in the present invention is: a kind of natural plants is anticorrosion, the self-microemulsifying drug delivery of antibacterial liquid, comprises following component and makes: plant extract, emulsifying agent, co-emulsifier and pure water.
Preferably, described plant extract is made up of two or more component any in Radix Vladimiriae volatile oil, tarragon essential oil, Folium Viticis Negundo volatile oil, Herba Artemisiae Annuae volatile oil, tea tree ethereal oil, Herba thymi vulgaris extract and Folium Ilicis Cornutae extracting solution.
The present invention uses natural plant extract as anticorrosion, antibacterial substance, plant extract is playing anticorrosion, antibacterial effect simultaneously, and side effect is significantly less than existing conventional antiseptic, simultaneously, plant extract also has health-care and skin-care effect, can play the effect of achieving many things at one stroke.
Preferably, described emulsifying agent is non-ionic surface active agent.
Further, described non-ionic surface active agent is span and/or tween.
Preferred further, described non-ionic surface active agent is Arlacel-80 and or tween 80.
Preferably, described co-emulsifier is chain alcohol.
Preferred further, described chain alcohol is 1,2-PD or Polyethylene Glycol.
Further, natural plants is anticorrosion, a self-microemulsifying drug delivery for antibacterial liquid, and the weight portion of its each component is: Radix Vladimiriae volatile oil 1 ~ 10 part, tarragon essential oil 1 ~ 10 part, Folium Viticis Negundo volatile oil 1 ~ 10 part, Herba Artemisiae Annuae volatile oil 1 ~ 10 part, tea tree ethereal oil 1 ~ 10 part, Herba thymi vulgaris extract 1 ~ 5 part, Folium Ilicis Cornutae extracting solution 1 ~ 10 part, span and/or polysorbas20 ~ 100, chain alcohol 10 ~ 20 parts, pure water 60 ~ 300 parts; It should be noted that, described plant extract is made up of two or more component any in Radix Vladimiriae volatile oil, tarragon essential oil, Folium Viticis Negundo volatile oil, Herba Artemisiae Annuae volatile oil, tea tree ethereal oil, Herba thymi vulgaris extract and Folium Ilicis Cornutae extracting solution, whole use might not be needed, presence or absence and the dosage of component can be adjusted as required.
Preferred further, natural plants is anticorrosion, a self-microemulsifying drug delivery for antibacterial liquid, and the weight portion of its each component is: Radix Vladimiriae volatile oil 5 parts, tarragon essential oil 5 parts, Folium Viticis Negundo volatile oil 5 parts, Herba Artemisiae Annuae volatile oil 5 parts, tea tree ethereal oil 5 parts, Herba thymi vulgaris extract 3 parts, Folium Ilicis Cornutae extracting solution 5 parts, span and/or polysorbate60 part, chain alcohol 15 parts, pure water 150 parts; It should be noted that, described plant extract is made up of two or more component any in Radix Vladimiriae volatile oil, tarragon essential oil, Folium Viticis Negundo volatile oil, Herba Artemisiae Annuae volatile oil, tea tree ethereal oil, Herba thymi vulgaris extract and Folium Ilicis Cornutae extracting solution, whole use might not be needed, the presence or absence of component can be adjusted as required.
Method also provides for a kind of preparation method of described self-microemulsifying drug delivery, comprise the following steps:
1) preparation of oil mixture: by the other plant extract mix homogeneously except Folium Ilicis Cornutae extracting solution, obtain oil mixture;
2) preparation of mixture I: slowly add emulsifying agent in described oil mixture, add pure water after stirring, obtains mixture I after stirring;
3) preparation of aqueous mixture: when there being Folium Ilicis Cornutae extracting solution in component, by described co-emulsifier, Folium Ilicis Cornutae extracting solution and pure water mix homogeneously, obtains aqueous mixture; When there is no Folium Ilicis Cornutae extracting solution in component, by described co-emulsifier and pure water mix homogeneously, obtain aqueous mixture;
4) finished product preparation: described aqueous mixture is joined in described mixture I, stirs; Then heat up heating, then carry out successively homogenizing, airtight, naturally cool to room temperature and obtain finished product.
Preferably, described step 2) in described oil mixture, slowly add emulsifying agent, add pure water after stirring, at 35 DEG C, stir 40 ~ 60min, after stirring, obtain mixture I; Described step 4) aqueous mixture is joined in described mixture I, use electrodeless constant speed stirrer, at 35 DEG C, stir 40 ~ 60min, be then warming up to 55 ~ 60 DEG C, re-use high cut disperse emulsification agent homogenizing 10 ~ 12min; Stir speed (S.S.) is 10000 ~ 16000rpm; Then airtight, naturally cool to room temperature and obtain finished product.
Present invention also offers a kind of self-microemulsifying drug delivery described above and prepare the application in cosmetics.
For solving the indissoluble problem of efficacy active component in cosmetics, present invention uses self-emulsifying microemulsion technology, self-emulsifying microemulsion is a kind of by oil phase, the preparation technique of emulsifying agent, co-emulsifier and aqueous phase composition, self-emulsifying microemulsion technology can provide good technology solution for material solubilisings such as cosmetic active thing, essence and quintessence oils because it has good solubilization.In the present invention, final finished product is " oil-in-water " system, and the diameter of the oil droplet in system is about 100nm, and this system can spontaneous formation and thermodynamically stable microemulsion, therefore self-emulsifying microemulsion technology has in industries such as medicine, food, cosmetics and applies very widely, and application prospect is good.
The dissolubility of essence and quintessence oil is less, but the amount of essence and quintessence oil needs to reach finite concentration competence exertion product effect in some products, but the solvent of some solubilisings can reduce product quality.Therefore, how not only product quality is ensured but also the effect that can play essence and quintessence oil is the difficult point that essence and quintessence oil add series products exploitation.Inventor, through research, finds to use the system of non-ionic surface active agent and chain alcohol composition greatly can increase the dissolubility of the plant extracts such as quintessence oil in cosmetics and bioavailability, serves good effect.
By self-emulsifying microemulsion technology is applied to cosmetics additive field, inventor finds that the micro emulsion cosmetics using self-emulsifying microemulsion technology to prepare have the advantages such as stability is high, the dissolubility of efficacy active component is high, particle diameter that is efficacy active component is small, preservative efficacy better, is easily absorbed by the skin, feel is fine and smooth, for the problems such as the dissolubility of cosmetic industry active component is little, difficult absorption provide good solution.
It should be noted that, owing to present invention uses self-emulsifying microemulsion technology, thus obtain the oil droplet of more small particle diameter, it is evident that, less particle diameter just means larger specific surface area, thus the plant extract in this method, i.e. anticorrosion, antipathogenic composition is from microcosmic, also larger with the contact area of extraneous composition, so anticorrosion, antibacterial effect is also better.
In addition, the present invention solves the problem that tradition is anticorrosion, antibacterial side effect is large, the invention provides a kind of safe, natural and there is anticorrosion, the antibacterial of health-care and skin-care effect, wherein mainly by plant extract as anticorrosion, antipathogenic composition, the pharmacological property of each component is as follows:
Radix Vladimiriae volatile oil is the extract of Radix Vladimiriae, and Radix Vladimiriae (Dolomiaea souliei) is Chinese medicine is also Tibetan medicine, and Radix Vladimiriae root, containing volatile oil, has good sterilization, bacteriostasis.There is inhibitory action to staphylococcus aureus, dysentery bacterium, bacillus pyocyaneus, have antibacterial, bactericidal action to gram-negative bacteria, yeast, especially antibacterial to gram positive bacteria, bactericidal action is stronger.Antibacterial, antiseptic, antiinflammatory is can be used as in cosmetics; And have strong inhibitory action to B-16 melanocyte, can be used for whitening product.
Estragon oil is the extract of Artemisia dracunculus (Artemisia dracunculus), containing esdragol 60-70%, has very strong fungistatic effect.There is antifungic action, and have very strong inhibitory action to Diplococcus pneumoniae, alpha streptococcus, catalin diplococcus, the pungent bacterium of Yale, false unicellular bacillus, staphylococcus aureus.Effect is had in addition, so can be used for the whitening product of cosmetics to B-16 cell proliferation; Proliferation function is had, so the collagen content in skin corium can be improved, for the anti-ageing of cosmetics and wrinkle resistant product to fibrous bud.
Folium Viticis Negundo volatile oil is the extract of Folium Viticis Negundo (Vitex negundo), is a kind of natural antibacterial agent, has antibacterial action to staphylococcus aureus, escherichia coli, group B streptococcus, dysentery bacterium, bacillus pyocyaneus.Folium Viticis Negundo has been used for the treatment of skin mucosa class disease by the approval of German certification office.The elimination of Folium Viticis Negundo volatile oil to superoxide radical and the elimination ability to hydroxyl radical free radical can be used for the anti-ageing product of cosmetics.
Herba Artemisiae Annuae volatile oil is the extract of Herba Artemisiae Annuae (Artemisia carvifolia), has broad spectrum antibacterial, tool bactericidal action, has stronger bacteriostasis to staphylococcus epidermidis, micrococcus catarrhalis.Bactericidal action is had to all dermatophytosises during 1% concentration.Herba Artemisiae Annuae extracting solution coating skin conductance measurement Value Data shows can significantly promote cuticular water content in addition.So except anti-corrosion function, can be used as the wetting agent of cosmetics simultaneously.
Tea tree ethereal oil (Melaleuca alternifolia) has antimicrobial acivity, biocidal efficacies, antibacterial activity, the nonirritant of All Pure Nature, separately has the advantage such as excellent Cutaneous permeation effect and unique armaticity.It can treat-cut scratch, and very fast with rear wound healing, hemostasis power is superpower, acne and sore, and comedo, mosquito bite, trick tinea etc. are also effective in cure to seasick carsick symptom, can be with fixed attention.
The extracting solution of Folium Ilicis Cornutae (Ilex cornuta) has strong antifungal activity, especially better to the inhibitory action of unicellular fungi candidiasis.Folium Ilicis Cornutae extract has inhibitory action to acyl CoA cholesterol ester acyltransferase in addition, can be used for the application of fat-reducing class cosmetics.
Herba thymi vulgaris (Thymus vulgaris) extract has very strong bactericidal action, all has inhibitory action in addition to gold-coloured staphylococci, escherichia coli.Herba thymi vulgaris extract has the suppression well to hyaluronidase simultaneously, can be used for the wetting agent of skin.
When reality uses, by different cosmetics need carry out the composite of plant extract, composite First Principles is exactly conform to the abnormal smells from the patient of cosmetics itself, is secondly anticorrosion, antibacterial from multiple angle such as anti-bacteria, Antifungi.By the synergism of two or more plant extract, play good, wide spectrum anticorrosion, fungistatic effect, meanwhile, due to the natural health function of plant extract, the effect of enhancing can be played to the active component of cosmetics.
Such as Mint toothpaste, composite tarragon essential oil, Folium Viticis Negundo volatile oil, tea tree ethereal oil, Herba thymi vulgaris extract etc. antiseptic can be done.Tarragon essential oil stresses Antifungi effect; Folium Viticis Negundo stresses anti-bacteria effect, and has the effect of auxiliary reparation oral mucosa concurrently; Tea tree ethereal oil stresses antimicrobial; Herba thymi vulgaris extract plays bactericidal action, comprehensively anticorrosion like this.And these are put together, the first two amount is slightly many, and latter two amount is on the low side, can ensure the identification of mint aroma, not affect the flavor characteristics of product.
Lavandula angustifolia man clarity oil-control matifying lotion for another example, can composite Folium Ilicis Cornutae extracting solution, tea tree ethereal oil.In addition, Radix Vladimiriae can in the composite product there being Radix Aucklandiae abnormal smells from the patient, and Herba Artemisiae Annuae lays particular emphasis on composite containing in the product of Chinese medicine extract; Folium Ilicis Cornutae lays particular emphasis on the composite anticorrosion of aqua product.
Beneficial effect of the present invention is:
1, the present invention is by providing a kind of self-microemulsifying drug delivery, increases the dissolubility of the plant extract such as quintessence oil in cosmetics and bioavailability, serves good effect.
2, the present invention uses plant extract as anticorrosion, antipathogenic composition, realizing anticorrosion, antibacterial effect simultaneously, has effect of health-care and skin-care.
Detailed description of the invention
Below in conjunction with embodiment, further illustrate content of the present invention.Should be appreciated that enforcement of the present invention is not limited to the following examples, any pro forma accommodation make the present invention and/or change all will fall into scope.
In the present invention, if not refer in particular to, all parts, percentage ratio are unit of weight, and all equipment and raw material etc. all can be buied from market or the industry is conventional.Method in following embodiment, if no special instructions, is the conventional method of this area.
Embodiment 1
A kind of natural plants is anticorrosion, the self-microemulsifying drug delivery of antibacterial liquid, composed of the following components: the Arlacel-80 of Radix Vladimiriae volatile oil 1g, tarragon essential oil 1g, Folium Viticis Negundo volatile oil 1g, Herba Artemisiae Annuae volatile oil 1g, tea tree ethereal oil 1g, Herba thymi vulgaris extract 1g, Folium Ilicis Cornutae extracting solution 1g, 10g, the tween 80 of 10g, 1,2-PD 10g, pure water 60g.
Embodiment 2
A kind of natural plants is anticorrosion, the self-microemulsifying drug delivery of antibacterial liquid, composed of the following components: the Arlacel-80 of Radix Vladimiriae volatile oil 10g, tarragon essential oil 10g, Folium Viticis Negundo volatile oil 10g, Herba Artemisiae Annuae volatile oil 10g, tea tree ethereal oil 10g, Herba thymi vulgaris extract 5g, Folium Ilicis Cornutae extracting solution 10g, 50g, the tween 80 of 50g, 1,2-PD 20g, pure water 300g.
Embodiment 3
A kind of natural plants is anticorrosion, the self-microemulsifying drug delivery of antibacterial liquid, composed of the following components: Radix Vladimiriae volatile oil 5g, tarragon essential oil 5g, Folium Viticis Negundo volatile oil 5g, Herba Artemisiae Annuae volatile oil 5g, tea tree ethereal oil 5g part, Herba thymi vulgaris extract 3g, Folium Ilicis Cornutae extracting solution 5g part, the Arlacel-80 of 25g, the tween 80 of 25g, 1,2-PD 15g, pure water 150g.
Embodiment 4
A kind of natural plants is anticorrosion, the self-microemulsifying drug delivery of antibacterial liquid, composed of the following components: Radix Vladimiriae volatile oil 10g, tarragon essential oil 10g, Herba Artemisiae Annuae volatile oil 10g, tea tree ethereal oil 10g, Herba thymi vulgaris extract 5g, the Arlacel-40 of 50g, 1,2-PD 20g, pure water 300g.
Embodiment 5
Natural plants is anticorrosion, a self-microemulsifying drug delivery for antibacterial liquid, composed of the following components: the Arlacel-60 of tarragon essential oil 5g, Folium Viticis Negundo volatile oil 5g, tea tree ethereal oil 5g part, Folium Ilicis Cornutae extracting solution 5g part, 25g, the Tween-60 of 25g, the PEG-4000 of 15g, pure water 150g.
Embodiment 6
Natural plants is anticorrosion, a self-microemulsifying drug delivery for antibacterial liquid, composed of the following components: the Tween-60 of Radix Vladimiriae volatile oil 10g, Folium Viticis Negundo volatile oil 10g, Herba Artemisiae Annuae volatile oil 10g, Herba thymi vulgaris extract 5g, Folium Ilicis Cornutae extracting solution 10g, 50g, the PEG-4000 of 20g, pure water 300g.
Wherein the preparation method of embodiment 1 ~ 6 is:
1) preparation of oil mixture: the other plant extract except Folium Ilicis Cornutae extracting solution is directly adopted conventional method mix homogeneously, obtains oil mixture;
2) preparation of mixture I: slowly add emulsifying agent in described oil mixture, add pure water after stirring, stirs 40 ~ 60min, obtains mixture I after stirring at 35 DEG C;
3) preparation of aqueous mixture: when there being Folium Ilicis Cornutae extracting solution in component, directly adopts conventional method mix homogeneously by described co-emulsifier, Folium Ilicis Cornutae extracting solution and pure water, obtains aqueous mixture; When there not being Folium Ilicis Cornutae extracting solution in component, described co-emulsifier and pure water directly being adopted conventional method mix homogeneously, obtains aqueous mixture;
4) finished product preparation: aqueous mixture is joined in described mixture I, described aqueous mixture and described mixture I are 35 DEG C, use electrodeless constant speed stirrer, 40 ~ 60min is stirred at 35 DEG C, obtain " oil-in-water " system, then be warming up to 55 ~ 60 DEG C, re-use high cut disperse emulsification agent homogenizing 10 ~ 12min; Stir speed (S.S.) is 10000 ~ 16000rpm.Then airtight, naturally cool to room temperature and obtain finished product.The i.e. self-microemulsifying drug delivery of anticorrosion, the antibacterial liquid of a kind of natural plants.
Applicant adopts paper disk method to measure the bacteriostatic activity of antiseptic of the present invention, and concrete process of the test is as follows:
1, test method
Escherichia coli (8099), staphylococcus aureus (ATCC6538) are inoculated cultured solution of broth respectively, at 37 DEG C, cultivates 24h; Candida albicans (ATCC10231) inoculation is husky protects weak fluid medium, at 25 DEG C, cultivate 5d; Aspergillus niger (ATCC16404) inoculates Cha Shi fluid medium, at 25 DEG C, cultivate 6d.With normal saline, four kinds of bacterial culturess being diluted to concentration is respectively 10
6the bacteria suspension of CFU/ml.
For comparing, comparative example 1 is set: by the Pure natural preservative for cosmetics a kind of disclosed in CN103494741A, be made up of the component of following weight portion: 1 ~ 3 part, Folium Nelumbinis, Flos Lonicerae 3 ~ 5 parts, Folium Ginkgo 2 ~ 5 parts, Fructus Mume 1 ~ 3 part, pomelo peel 1 ~ 5 part.
Respectively above-mentioned four kinds of bacteria suspensions are coated on aseptic cotton carrier and make lawn on nutrient agar panel, then cut-off footpath is the sterilizing filter paper dick of 3cm, after evenly picking the antiseptic that embodiment 1 ~ 4 and comparative example 1 make respectively, then be attached to respectively on flat board that four kinds of different bacteria suspensions make.Antibacterial culturing 24h, fungal culture 5d, observed result.
2, evaluation methodology:
Paper disk method bacteriostatic diameter >=10mm is that effectively bacteriostatic diameter < 10mm is invalid.
3, result of the test is in table 1
Table 1 paper disk method antiseptic fungistatic effect
As seen from the above table, the antiseptic that embodiment 1 ~ 4 obtains all has obvious inhibitory action to four kinds of antibacterials, and significantly better than the antiseptic in comparative example 1.
The present invention is not limited to above-mentioned preferred forms; anyone can draw other various forms of products under enlightenment of the present invention; no matter but any change is done in its shape or structure; every have identical with the application or akin technical scheme, all drops within protection scope of the present invention.
Claims (10)
1. a self-microemulsifying drug delivery for anticorrosion, the antibacterial liquid of natural plants, is characterized in that, comprise following component and make: plant extract, emulsifying agent, co-emulsifier and pure water.
2. self-microemulsifying drug delivery according to claim 1, it is characterized in that, described plant extract is made up of two or more component any in Radix Vladimiriae volatile oil, tarragon essential oil, Folium Viticis Negundo volatile oil, Herba Artemisiae Annuae volatile oil, tea tree ethereal oil, Herba thymi vulgaris extract and Folium Ilicis Cornutae extracting solution.
3. self-microemulsifying drug delivery according to claim 2, is characterized in that, described emulsifying agent is non-ionic surface active agent.
4. self-microemulsifying drug delivery according to claim 3, is characterized in that, described non-ionic surface active agent is span and/or tween.
5. self-microemulsifying drug delivery according to claim 4, is characterized in that, described co-emulsifier is chain alcohol.
6. self-microemulsifying drug delivery according to claim 5, it is characterized in that, the weight portion of its each component is: Radix Vladimiriae volatile oil 1 ~ 10 part, tarragon essential oil 1 ~ 10 part, Folium Viticis Negundo volatile oil 1 ~ 10 part, Herba Artemisiae Annuae volatile oil 1 ~ 10 part, tea tree ethereal oil 1 ~ 10 part, Herba thymi vulgaris extract 1 ~ 5 part, Folium Ilicis Cornutae extracting solution 1 ~ 10 part, span and/or polysorbas20 ~ 100, chain alcohol 10 ~ 20 parts, pure water 60 ~ 300 parts.
7. self-microemulsifying drug delivery according to claim 5, it is characterized in that, the weight portion of its each component is: Radix Vladimiriae volatile oil 5 parts, tarragon essential oil 5 parts, Folium Viticis Negundo volatile oil 5 parts, Herba Artemisiae Annuae volatile oil 5 parts, tea tree ethereal oil 5 parts, Herba thymi vulgaris extract 3 parts, Folium Ilicis Cornutae extracting solution 5 parts, span and/or polysorbate60 part, chain alcohol 15 parts, pure water 150 parts.
8. a preparation method for self-microemulsifying drug delivery according to claims 2 to 7, is characterized in that, comprises the following steps:
1) preparation of oil mixture: by the other plant extract mix homogeneously except Folium Ilicis Cornutae extracting solution, obtain oil mixture;
2) preparation of mixture I: slowly add emulsifying agent in described oil mixture, add pure water after stirring, obtains mixture I after stirring;
3) preparation of aqueous mixture: when there being Folium Ilicis Cornutae extracting solution in component, by described co-emulsifier, Folium Ilicis Cornutae extracting solution and pure water mix homogeneously, obtains aqueous mixture; When there is no Folium Ilicis Cornutae extracting solution in component, by described co-emulsifier and pure water mix homogeneously, obtain aqueous mixture;
4) finished product preparation: described aqueous mixture is joined in described mixture I, stirs; Then heat up heating, then carry out successively homogenizing, airtight, naturally cool to room temperature and obtain finished product.
9. a preparation method according to claim 8, is characterized in that, described step 2) in described oil mixture, slowly add emulsifying agent, add pure water after stirring, at 35 DEG C, stir 40 ~ 60min, after stirring, obtain mixture I; Described step 4) aqueous mixture is joined in described mixture I, use electrodeless constant speed stirrer, at 35 DEG C, stir 40 ~ 60min, be then warming up to 55 ~ 60 DEG C, re-use high cut disperse emulsification agent homogenizing 10 ~ 12min; Stir speed (S.S.) is 10000 ~ 16000rpm; Then airtight, naturally cool to room temperature and obtain finished product.
10. preparing the application in cosmetics according to the described self-microemulsifying drug delivery of one of claim 1-7 for one kind.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510338093.3A CN104983589B (en) | 2015-06-16 | 2015-06-16 | A kind of self-microemulsifying drug delivery and preparation method thereof of natural plants anti-corrosion, antibacterial liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510338093.3A CN104983589B (en) | 2015-06-16 | 2015-06-16 | A kind of self-microemulsifying drug delivery and preparation method thereof of natural plants anti-corrosion, antibacterial liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104983589A true CN104983589A (en) | 2015-10-21 |
| CN104983589B CN104983589B (en) | 2018-06-15 |
Family
ID=54295586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510338093.3A Active CN104983589B (en) | 2015-06-16 | 2015-06-16 | A kind of self-microemulsifying drug delivery and preparation method thereof of natural plants anti-corrosion, antibacterial liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104983589B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281012A (en) * | 2017-07-25 | 2017-10-24 | 佛山市绿植生物科技有限公司 | A kind of mosquito-driving liquid and preparation method thereof |
| CN108030711A (en) * | 2017-12-18 | 2018-05-15 | 东莞俏美肌生物科技有限公司 | Skin whitening care cosmetics |
| CN110742827A (en) * | 2019-09-27 | 2020-02-04 | 华南师范大学 | Anticorrosive composition and application thereof |
| CN113773910A (en) * | 2021-09-30 | 2021-12-10 | 梵申兰科技(上海)有限公司 | Artemisia annua essential oil and white tea essential oil for promoting skin cell regeneration and their composition |
| CN114522133A (en) * | 2022-02-26 | 2022-05-24 | 上海应用技术大学 | Antibacterial microemulsion, preparation method and application thereof, moisturizing lotion, moisturizing emulsion, moisturizing cream and preparation method thereof |
| CN114668147A (en) * | 2022-03-25 | 2022-06-28 | 华南农业大学 | Melaleuca alternifolia compound essential oil microemulsion and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006002089A2 (en) * | 2004-06-22 | 2006-01-05 | Wille John J | Novel topical delivery system for plant derived anti-irritants |
| CN101703457A (en) * | 2009-11-25 | 2010-05-12 | 李俊彦 | Bamboo leaf antiageing skin-nourishing mask |
| CN102845512A (en) * | 2012-07-28 | 2013-01-02 | 海南大学 | Water-soluble tea tree oil/chitosan antibacterial compound |
-
2015
- 2015-06-16 CN CN201510338093.3A patent/CN104983589B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006002089A2 (en) * | 2004-06-22 | 2006-01-05 | Wille John J | Novel topical delivery system for plant derived anti-irritants |
| CN101703457A (en) * | 2009-11-25 | 2010-05-12 | 李俊彦 | Bamboo leaf antiageing skin-nourishing mask |
| CN102845512A (en) * | 2012-07-28 | 2013-01-02 | 海南大学 | Water-soluble tea tree oil/chitosan antibacterial compound |
Non-Patent Citations (8)
| Title |
|---|
| 屠呦呦: "《青蒿及青蒿素类药物》", 31 January 2009, 化学工业出版社 * |
| 张卫明等: "《芳香疗法和芳疗植物》", 31 August 2009, 东南大学出版社 * |
| 板仓弘重: "《花草茶养生图鉴》", 31 May 2006, 浙江科学技术出版社 * |
| 王建新: "《化妆品植物原料手册》", 30 June 2009, 化学工业出版社 * |
| 章苏宁: "《化妆品工艺学》", 30 September 2007, 中国轻工业出版社 * |
| 袁端红等: "《疏肝养肝滋阴补血中草药及处方：不可不知的肝及相关疾病必用药》", 31 July 2014, 贵州科技出版社 * |
| 陈吉炎等: "《中国武当中草药志》", 28 February 2009, 湖北科学技术出版社 * |
| 颜红侠: "《现代精细化工实验》", 31 January 2015, 西北工业大学出版社 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281012A (en) * | 2017-07-25 | 2017-10-24 | 佛山市绿植生物科技有限公司 | A kind of mosquito-driving liquid and preparation method thereof |
| CN108030711A (en) * | 2017-12-18 | 2018-05-15 | 东莞俏美肌生物科技有限公司 | Skin whitening care cosmetics |
| CN110742827A (en) * | 2019-09-27 | 2020-02-04 | 华南师范大学 | Anticorrosive composition and application thereof |
| CN113773910A (en) * | 2021-09-30 | 2021-12-10 | 梵申兰科技(上海)有限公司 | Artemisia annua essential oil and white tea essential oil for promoting skin cell regeneration and their composition |
| CN113773910B (en) * | 2021-09-30 | 2022-11-08 | 梵申兰科技(上海)有限公司 | Artemisia annua essential oil and white tea essential oil for promoting skin cell regeneration and their composition |
| CN114522133A (en) * | 2022-02-26 | 2022-05-24 | 上海应用技术大学 | Antibacterial microemulsion, preparation method and application thereof, moisturizing lotion, moisturizing emulsion, moisturizing cream and preparation method thereof |
| CN114668147A (en) * | 2022-03-25 | 2022-06-28 | 华南农业大学 | Melaleuca alternifolia compound essential oil microemulsion and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104983589B (en) | 2018-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104983589A (en) | Self-micro-emulsifying liquid of natural plant corrosion prevention and bacterium inhibition liquid and preparing method of self-micro-emulsifying liquid | |
| Chen et al. | Formulation and evaluation of antibacterial creams and gels containing metal ions for topical application | |
| CN103262839B (en) | Mosquito repelling gel composition with natural plant essential oil | |
| Cui et al. | Inhibitory effect of liposome-entrapped lemongrass oil on the growth of Listeria monocytogenes in cheese | |
| CN108158869A (en) | A kind of antibacterial wet tissue liquid, wet tissue and preparation method thereof | |
| CN109288691A (en) | A kind of graphene facial mask and preparation method thereof | |
| CN102821744A (en) | Microbiologically stable, easy-to-use formulations | |
| Pooja et al. | Screening of plant essential oils for antifungal activity against Malassezia furfur | |
| CN105199462A (en) | Plant sterilizing insect-repelling functional type inner wall emulsion paint and preparation method thereof | |
| CN101606896A (en) | New purposes of Folium Bambosae extract and method for making, its skin-care bath composition and method for making | |
| CN105076246A (en) | Antibacterial traditional Chinese medicine composition, preparing method of antibacterial traditional Chinese medicine composition and application of antibacterial traditional Chinese medicine composition | |
| CN103860547B (en) | A kind of herbal composite antimicrobial nano breast and preparation method thereof | |
| CN104644499A (en) | Composition with powerful preservative effect and application of composition in cosmetics | |
| CN102802649A (en) | Cosmetic or dermatological composition containing hydrolyzates made of plant extracts | |
| CN108078863B (en) | Bactericidal composition based on plant extracts and infant care composition | |
| CN106726998A (en) | A kind of acne-removing liquid containing Tea Flower extract solution | |
| CN102600053A (en) | Chinese medicinal herb-inorganic antibacterial agent composite sterilization hand sanitizer and preparation thereof | |
| CN111888306A (en) | Essence for removing blackheads and repairing rosacea and preparation method thereof | |
| CN111493097A (en) | Collective disinfectant for inhibiting viruses and pathogenic bacteria and preparation method thereof | |
| CN105963151A (en) | No-preservative composite used for cosmetics corrosion prevention | |
| CN103735434B (en) | A kind of natural plant compound and daily chemical products with anti-corrosion effect | |
| CN108542805A (en) | Anti-acne compound essential oil preparation and its preparation method and application | |
| CN105362140B (en) | A kind of non-cosmetics preservative composition and its application with preservative efficacy | |
| Pengon et al. | Development of antimicrobial nanoemulsions containing Nelumbo nucifera extract | |
| CN106983691A (en) | A kind of anti-oxidant pore refining sleep mask of the polyphenol containing lotus and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: Room 520, No. 155-5 Innovation Road, Dongling District, Shenyang City, Liaoning Province, 110000 Patentee after: Liaoning Upward Technology Co., Ltd. Address before: 114217 No. 66 Dongfanghong Street, Niuzhuang Town, Haicheng City, Anshan City, Liaoning Province Patentee before: LIAONING XIANGSHANG INDUSTRY CO., LTD. |
|
| CP03 | Change of name, title or address |