CN108078863B - Bactericidal composition based on plant extracts and infant care composition - Google Patents
Bactericidal composition based on plant extracts and infant care composition Download PDFInfo
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- CN108078863B CN108078863B CN201810082063.4A CN201810082063A CN108078863B CN 108078863 B CN108078863 B CN 108078863B CN 201810082063 A CN201810082063 A CN 201810082063A CN 108078863 B CN108078863 B CN 108078863B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a plant extract-based bactericidal composition, which comprises the following components in percentage by weight: 1.0-3.0% of grapefruit fruit extract, 3.0-10.0% of magnolia bark extract, 3.0-8.0% of ginger root extract, 3.0-8.0% of pepper extract and 71-90% of polyalcohol. The composition of the invention has outstanding performance in the aspect of durable antibacterial property. The composition contains grapefruit fruit extract, magnolia bark extract, ginger root extract, zanthoxylum bungeanum extract and polyhydric alcohol, can effectively control most of bacteria and mold which are difficult to control in cosmetics, and is mild in property, free of irritation, free of heat and very safe. The composition can effectively kill bacteria, mould and yeast in cosmetics, and the components of the composition are not in a list of standard preservatives specified in cosmetic safety technical specification, so that the requirement of a product on a preservative-free concept is met.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to a bactericidal composition based on plant extracts.
Background
Chinese patent application cn201510899803.x discloses a plant-derived cosmetic preservative composition and a preparation method thereof, comprising a preservative mixture consisting of grapefruit seed extract, oregano whole plant extract, magnolia bark extract, characterized in that raspberry fruit extract and sophora flower extract are used to perform preservative synergism on the preservative mixture. The preserved mixture, the raspberry fruit extract, and the sophora flower extract are coated with a lipid material to form a sub-micron emulsion. The lipid material is prepared from the following components in a mass ratio of 5-10: 1-3:3-5: 20-50 of mannitol erythritol ester, surfactin sodium, hydrogenated lysolecithin and glycerol. The antiseptic composition has low irritation and good antiseptic effect.
In the scheme, raspberry fruit extract and sophora flower extract are adopted to perform preservative synergism on the preservative mixture.
Chinese patent application CN201510522007.4 discloses an organic natural plant preservative, which comprises the following raw materials: the traditional Chinese medicine composition comprises a common sorbus fruit extract, a magnolia bark extract, a elderberry fruit extract, a common populus bark extract, a radish root fermentation product filtrate produced by fermenting staphylococcus, a honeysuckle flower extract, a liquorice root extract, a peony extract, an oriental cattail extract, a french lavender extract, a grapefruit extract, a mugwort leaf extract, a peony root bark extract, a scutellaria root extract, a garlic extract, a polygonum multiflorum extract, a polygonum cuspidatum extract, 1, 2-pentanediol and 1, 2-hexanediol. The organic natural plant preservative disclosed by the invention is used for forming a preservative system of a skin care product in the skin care product, and can effectively inhibit bacterial breeding.
The scheme adopts multiple plant extracts for combination, and can achieve the effects of comprehensive antisepsis and bacteriostasis.
Chinese patent application CN201611073111.0 discloses a preservative and bactericidal composition which mainly comprises 0.1-1 part of pomelo peel extract, 0.1-1 part of magnolia bark extract and 0.1-1 part of sweet wormwood herb extract, has good preservative and bactericidal effects, and has no irritation to skin.
The examples of this embodiment demonstrate that the extract of pomelo peel, the extract of magnolia bark, and the extract of artemisia annua are absent.
Chinese patent application CN201510801718.5 discloses a natural plant preservative composition, which comprises the following components by weight percent: 1-10% of a filtrate of a fermentation product of the leuconostoc/radish root, 1-10% of an extract of bark of magnolia officinalis, 1-10% of an extract of scutellaria baicalensis, 1-10% of an extract of peony root, and the balance of corn propylene glycol and water. All raw materials of the natural plant preservative composition are natural sources, and various rich functional components are mutually blended and cooperated, so that the product has a remarkable preservative effect.
The above documents can be analyzed to find that:
1. undeniably, cortex Magnolia officinalis extract, Sorbus commixta fruit extract, and grapefruit fruit extract all have bactericidal effects.
2. The above documents have a clear disadvantage in terms of composition.
The above documents contribute to the wide range of plant antibacterial extracts found in nature. The problems in the prior art are that: based on the existing findings, how to combine the effects, and develop a more efficient and reasonable composition.
The most effective composition of the above-mentioned comparison documents, too, cannot achieve an excellent bacteriostatic effect in a short time according to the technical solution disclosed in cn201510899803. x.
As a further improvement and improvement of the prior art, the skilled person considers, in addition to the plant extracts, other ingredients in combination with bacteriostatic methods, such as the natural broad-spectrum preservative composition containing grapefruit seed extract disclosed in CN2015108753460, which contains grapefruit seed extract, a hydroximic acid, an aromatic alcohol, and one or more polyols, which formulation is capable of maintaining high bactericidal efficiency over a period of 7 days.
From the above documents, it can be found that fungicides based on plant compositions are a trend in the future. There is a need to develop a wider variety of plant composition-based fungicides that provide better bactericidal efficacy and simpler formulation.
Disclosure of Invention
The invention aims to provide a bactericidal composition based on plant extracts, which has outstanding performance in the aspect of durable antibacterial property. The composition contains grapefruit fruit extract, magnolia bark extract, ginger root extract, zanthoxylum bungeanum extract and polyhydric alcohol, can effectively control most of bacteria and mold which are difficult to control in cosmetics, and is mild in property, free of irritation, free of heat and very safe. The composition can effectively kill bacteria, mould and yeast in cosmetics, and the components of the composition are not in a list of standard preservatives specified in cosmetic safety technical specification, so that the requirement of a product on a preservative-free concept is met.
The invention also aims to provide application of a composition containing grapefruit fruit extract, magnolia bark extract, ginger root extract, pepper extract and polyhydric alcohol in preparation of a preservative-free product for infants. The composition is suitable for products such as emulsion, cream, shampoo and bath lotion, has low addition amount, can reduce production cost of cosmetics, does not release harmful substances such as formaldehyde in cosmetics, and is mild and non-irritating.
The specific technical scheme of the invention is as follows: the plant extract-based bactericidal composition comprises the following components in percentage by weight:
1.0-3.0% of grapefruit fruit extract, 3.0-10.0% of magnolia bark extract, 3.0-8.0% of ginger root extract, 3.0-8.0% of pepper extract and 71-90% of polyalcohol.
The grapefruit fruit extract is derived from grapefruit fruits and is a natural source, has a good inhibiting effect on bacteria such as escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and the like, fungi such as candida albicans and the like, viruses such as avian influenza and the like, can replace a harsh chemical method to inhibit bacteria, fungi, yeasts and viruses, and is an all-natural preservative substance which can be safely used in foods and cosmetics; the cortex Magnolia officinalis extract has broad-spectrum antibacterial property, and the magnolol contained therein has high-efficiency inhibitory effect on Escherichia coli, Staphylococcus aureus, Salmonella, Bacillus subtilis, Saccharomyces cerevisiae and Aspergillus niger; the volatile oil contained in the ginger root extract has strong antifungal activity, and the gingerol, the diphenyl heptane and the flavonoid compound have strong antiseptic and antioxidant effects; the pepper extract contains volatile oil, alkaloid and amide substances, and has good bacteriostatic action on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, candida albicans and the like; the polyols can enhance the preservative effect in the composition. The composition has synergistic effect, can kill most of bacteria, mold, yeast, etc., and is mild and non-irritating, and can effectively reduce irritation of surfactant in system.
The plant extract-based bactericidal composition comprises the following components in percentage by weight:
1.5-2.5% of grapefruit fruit extract, 4-8% of magnolia bark extract, 5-7% of ginger root extract, 5-7% of zanthoxylum bungeanum extract and 75.5-84.5% of polyhydric alcohol.
In the plant extract-based bactericidal composition, the polyhydric alcohol comprises any one or more of glycerol, 1, 2-propanediol, 1, 3-propanediol, 1, 2-butanediol, 1, 2-pentanediol, 1, 5-pentanediol, and 3- [2- (ethylhexyl) oxy ] -1, 2-propanediol.
Meanwhile, the invention also discloses an infant care composition, which contains 0.3-0.7 wt% of the bactericidal composition.
Compared with the prior art, the invention has the beneficial effects that:
the formula of the invention achieves excellent anticorrosion effect under the condition of extremely small dosage, and the compatibility synergistic effect is good.
Particularly, the grapefruit fruit extract is derived from grapefruit fruits and is a natural source, and the grapefruit fruit extract has a good inhibiting effect on bacteria such as escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and the like, fungi such as candida albicans and the like, and viruses such as avian influenza and the like; the cortex Magnolia officinalis extract has broad-spectrum antibacterial property, and the magnolol contained therein has high-efficiency inhibitory effect on Escherichia coli, Staphylococcus aureus, Salmonella, Bacillus subtilis, Saccharomyces cerevisiae and Aspergillus niger; the volatile oil contained in the ginger root extract has strong antifungal activity, and the gingerol, the diphenyl heptane and the flavonoid compound have strong antiseptic and antioxidant effects; the pepper extract contains volatile oil, alkaloid and amide substances, and has good bacteriostatic action on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, candida albicans and the like; the polyols can enhance the preservative effect in the composition. The composition has synergistic effect, and can kill most of bacteria, mold, yeast, etc.
Detailed Description
The technical solution of the present invention will be described in further detail with reference to the following embodiments, but the present invention is not limited thereto.
Example 1
The composition is applied to infant cream products, and the formula is as follows:
the preparation process of the cream product comprises the following steps:
accurately weighing each component of the phase A, adding the component into an oil phase pot, starting stirring and heating, heating to 85 ℃, completely dissolving, and keeping the temperature for 10 minutes;
accurately weighing each component of phase B, adding into a vacuum emulsifying pot, starting a homogenizer, heating to above 90 ℃, homogenizing until the components are completely dissolved, and keeping the temperature for 10 minutes;
pumping the phase A into a vacuum emulsifying pot, stirring and pumping, starting a homogenizer, quickly homogenizing for 6 minutes, and then preserving heat for 10 minutes;
adding a C phase component dispersed by a small amount of water, homogenizing for 1 minute, and keeping the temperature and stirring for more than 15 minutes;
cooling water is introduced into the jacket of the emulsifying pot, the temperature is reduced to 45-50 ℃, and the phase D and the phase E are added and fully and uniformly stirred;
and continuously stirring and cooling to form paste.
In this example, the preservative composition consisted of 2.0 wt% grapefruit fruit extract, 5.0 wt% magnolia bark extract, 5.0 wt% ginger root extract, 5.0 wt% zanthoxylum bungeanum extract and 83 wt% 1, 2-propanediol.
The preparation method of the anticorrosive composition comprises the following steps: mixing the above materials.
Comparative example 1
Comparative example 1 is similar to the formulation and preparation process of example 1, except that the preservative composition of comparative example 1 does not contain grapefruit fruit extract, and the preservative composition comprises, in weight percent: 5% of cortex magnoliae officinalis extract, 5% of ginger root extract, 5% of pepper extract and 85% of 1, 2-propylene glycol.
Comparative example 2
Comparative example 2 is similar to the formulation and preparation process of example 1, except that the preservative composition of comparative example 2 does not contain magnolia bark extract, and the preservative composition comprises, in weight percent: 2% of grapefruit fruit extract, 5% of ginger root extract, 5% of pepper extract and 88% of 1, 2-propylene glycol.
Comparative example 3
Comparative example 3 is similar to the formulation and preparation process of example 1, except that the preservative composition of comparative example 3 does not contain ginger root extract, and the preservative composition comprises the following components in percentage by weight: 2% of grapefruit fruit extract, 5% of magnolia bark extract, 5% of pepper extract and 88% of 1, 2-propylene glycol.
Comparative example 4
Comparative example 4 is similar to the formulation and preparation process of example 1, except that the preservative composition in comparative example 4 does not contain zanthoxylum bungeanum extract, and the preservative composition comprises the following components in percentage by weight: 2% of grapefruit fruit extract, 5% of magnolia bark extract, 5% of ginger root extract and 88% of 1, 2-propylene glycol.
Example 2
The composition is applied to infant shampoo products, and the formula is as follows:
the preparation process of the shampoo product comprises the following steps:
accurately weighing each component of the phase A, adding the components into a vacuum emulsifying pot, homogenizing until the components are uniformly dispersed, heating to 85-90 ℃, and preserving the heat for 25 minutes;
adding the phase B components, and uniformly stirring;
cooling water is introduced into the jacket of the emulsifying pot, the temperature is reduced to 45-50 ℃, and the C-phase components are added and fully and uniformly stirred;
and continuously stirring and cooling to room temperature.
In this example, the preservative composition consisted of 3.0 wt% grapefruit fruit extract, 3.0 wt% magnolia bark extract, 8.0 wt% ginger root extract, 3.0 wt% zanthoxylum bungeanum extract and 83 wt% 1, 2-butanediol.
The preparation method of the anticorrosive composition comprises the following steps: mixing the above materials.
Comparative example 5
Comparative example 5 is similar to the formulation and preparation process of example 2, except that the preservative composition of comparative example 5 does not contain grapefruit fruit extract, and the preservative composition comprises, in weight percent: 3% of cortex magnoliae officinalis extract, 8% of ginger root extract, 3% of pepper extract and 86% of 1, 2-butanediol.
Comparative example 6
Comparative example 6 the formulation and preparation process of example 2 are similar except that the preservative composition of comparative example 6 does not contain magnolia bark extract and the preservative composition comprises, in weight percent: 3% of grapefruit fruit extract, 8% of ginger root extract, 3% of pepper extract and 86% of 1, 2-butanediol.
Comparative example 7
Comparative example 7 is similar to the formulation and preparation process of example 2, except that the preservative composition of comparative example 7 does not contain ginger root extract, and the preservative composition comprises, by weight: 3% of grapefruit fruit extract, 3% of magnolia bark extract, 3% of pepper extract and 91% of 1, 2-butanediol.
Comparative example 8
Comparative example 8 is similar to the formulation and preparation process of example 2, except that the preservative composition in comparative example 8 does not contain zanthoxylum bungeanum extract, and the preservative composition comprises the following components in percentage by weight: 3% of grapefruit fruit extract, 3% of magnolia bark extract, 8% of ginger root extract and 86% of 1, 2-butanediol.
Example 3
The composition is applied to infant shampoo products, and the formula is as follows:
the preparation process of the shampoo product comprises the following steps:
accurately weighing each component of the phase A, adding the components into a vacuum emulsifying pot, homogenizing until the components are uniformly dispersed, heating to 85-90 ℃, and preserving the heat for 25 minutes;
adding the phase B components, and uniformly stirring;
cooling water is introduced into the jacket of the emulsifying pot, the temperature is reduced to 45-50 ℃, and the C-phase components are added and fully and uniformly stirred;
and continuously stirring and cooling to room temperature.
In this example, the preservative composition consisted of 1.0 wt% grapefruit fruit extract, 10.0 wt% magnolia bark extract, 3.0 wt% ginger root extract, 8.0 wt% zanthoxylum bungeanum extract and 78 wt% glycerol.
The preparation method of the anticorrosive composition comprises the following steps: mixing the above materials.
The test strains are Escherichia coli ATCC8739, Staphylococcus aureus ATCC6538, Pseudomonas aeruginosa ATCC9027, Candida albicans ATCC10231, Candida albicans NCPF3179, Aspergillus niger ATCC16404, Trichoderma viride GIM3.139 and Penicillium funiculosum GIM 3.103. the evaluation standard of the CTFA is that the inoculation amounts of mixed bacteria, mixed molds and mixed yeasts are respectively 1 × 106CFU/g(CFU/m1)、l×104CFU/g (CFU/m1) and 1 × 104CFU/g (CFU/m1), requires 99.9% reduction in bacteria, 90% reduction in each of mold and yeast at day 7, and a sustained reduction over 28 days. The results are as follows:
table one: corrosion efficacy results for example 1 and comparative examples 1-4:
table two: corrosion efficacy results for example 2 and comparative examples 5-8:
as can be seen from the results in tables I and II, in examples 1 to 3, the number of bacteria and fungi was less than 10 from day 1 to day 28, and the results were in accordance with the restriction of the microorganism index in the cosmetics specified in "technical Specification for safety of cosmetics". Comparative examples 1 to 8, on day 7, the bacteria were not reduced by 99.9%, and as a result, the regulation of the microbial indicator limit in cosmetics, which was specified in "technical Specification for safety of cosmetics", was not satisfied.
The above description is only exemplary of the invention, and any modification, equivalent replacement, and improvement made within the spirit and scope of the present invention should be considered within the scope of the present invention.
Claims (4)
1. The plant extract-based bactericidal composition is characterized by comprising the following components in percentage by weight:
1.0-3.0% of grapefruit fruit extract, 3.0-10.0% of magnolia bark extract, 3.0-8.0% of ginger root extract, 3.0-8.0% of pepper extract and 71-90% of polyalcohol.
2. The plant extract-based bactericidal composition according to claim 1, comprising the following components in percentage by weight:
1.5-2.5% of grapefruit fruit extract, 4-8% of magnolia bark extract, 5-7% of ginger root extract, 5-7% of zanthoxylum bungeanum extract and 75.5-84.5% of polyhydric alcohol.
3. The plant extract-based fungicidal composition according to claim 1 or 2, wherein the polyhydric alcohol comprises any one or more of glycerol, 1, 2-propanediol, 1, 3-propanediol, 1, 2-butanediol, 1, 2-pentanediol, 1, 5-pentanediol, and 3- [2- (ethylhexyl) oxy ] -1, 2-propanediol.
4. An infant care composition characterized in that said composition comprises 0.3-0.7 wt% of the germicidal composition as claimed in any one of claims 1-3.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110731932A (en) * | 2019-11-19 | 2020-01-31 | 山东义才和锐生物技术有限公司 | plant bacteriostatic cream and preparation method thereof |
| CN112791020A (en) * | 2020-12-29 | 2021-05-14 | 陕西省石油化工研究设计院 | Plant source-based preservative for cosmetics and preparation method thereof |
| CN112587458A (en) * | 2020-12-29 | 2021-04-02 | 花安堂生物科技集团有限公司 | Preservative composition and preparation method and application thereof |
| CN113413341B (en) * | 2021-06-24 | 2022-06-07 | 广州萃普生物科技有限公司 | Plant source compound bacteriostatic agent |
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| CN105055244A (en) * | 2015-08-24 | 2015-11-18 | 上海东晟源日化有限公司 | Organic natural plant preservative |
| CN105232411A (en) * | 2015-11-18 | 2016-01-13 | 中山市艾丽意素生物科技有限公司 | Natural plant preservative combination and application thereof in cosmetics |
| CN105707139A (en) * | 2014-12-23 | 2016-06-29 | 株式会社韩国人参公社 | Natural preservative composition |
| CN105902445A (en) * | 2016-06-15 | 2016-08-31 | 广东芭薇生物科技股份有限公司 | Botanical corrosion remover composition for cosmetics and preparation method of botanical corrosion remover composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105707139A (en) * | 2014-12-23 | 2016-06-29 | 株式会社韩国人参公社 | Natural preservative composition |
| CN105055244A (en) * | 2015-08-24 | 2015-11-18 | 上海东晟源日化有限公司 | Organic natural plant preservative |
| CN105232411A (en) * | 2015-11-18 | 2016-01-13 | 中山市艾丽意素生物科技有限公司 | Natural plant preservative combination and application thereof in cosmetics |
| CN105902445A (en) * | 2016-06-15 | 2016-08-31 | 广东芭薇生物科技股份有限公司 | Botanical corrosion remover composition for cosmetics and preparation method of botanical corrosion remover composition |
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