CN112618395B - Mite-killing composition and preparation method and application thereof - Google Patents
Mite-killing composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN112618395B CN112618395B CN202011639501.6A CN202011639501A CN112618395B CN 112618395 B CN112618395 B CN 112618395B CN 202011639501 A CN202011639501 A CN 202011639501A CN 112618395 B CN112618395 B CN 112618395B
- Authority
- CN
- China
- Prior art keywords
- mite
- killing
- composition
- killing composition
- honokiol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides an acarid-removing composition, a preparation method and application thereof. The mite-killing composition comprises the following components in parts by weight: 0.01 to 0.3 part of honokiol; 0.01 to 0.3 part of peach toposide; 0.1 to 2 portions of nano sulfur. The mite-killing composition provided by the invention is compounded by utilizing various plant extracts, contains natural plant components, is mild and non-irritating, has the synergistic effect of various active components, can play a good role in sterilizing and killing mites under the condition of low usage amount, and can also reduce the usage amount of preservatives in cosmetics and reduce the irritation to skin.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an anti-mite composition as well as a preparation method and application thereof.
Background
Human demodex is a conditionally pathogenic small parasitic mite, two common types of demodex folliculorum and demodex sebaceous gland are mainly parasitic in hair follicles and sebaceous glands, and weak resistance to high temperature, dryness and alkaline environment can cause various common skin diseases under certain conditions, and possible mechanisms for causing skin damage include mechanical blockage of hair follicles, hair follicle expansion and excessive keratinization; resistance is reduced, and bacterial and fungal infections are easily caused; the chitin exoskeleton of mites contributes to granuloma formation; demodex faeces may activate the immune system and cause delayed hypersensitivity etc. which seriously affect the health and beauty of people.
The most of the products which are used for mildly removing mites by using plant preparations in the market at present are to add plant extracts with the effects of sterilizing and removing mites, such as patent CN111789786A, and the mite-removing plant composition is disclosed, wherein the mite-removing effect is realized by the synergistic effect among rosewood seed extract, pepper fruit extract, radix sophorae flavescentis extract, stemona root extract and cortex phellodendri extract, the active ingredients which are mainly used for the preparations are usually not high, a large addition amount is often required to really realize the mite-removing effect, and the extracts related to the herbal medicines also contain more other complex ingredients and extraction solvents, and a large amount of the extracts are added into the products to have other potential risks, so that the stability, the appearance, the smell and the like of the system can be influenced. In addition, certain amounts of chemical mite-removing agents are added or compounded in the formula by a merchant to achieve a better mite-removing effect, but the chemical mite-removing agents often have certain irritation to skin, and certain chemical mite-removing agents also have certain toxicity.
In general, there is currently a lack of technical applications associated with natural actives that achieve high levels of mite removal and are mild and non-irritating.
Disclosure of Invention
The invention aims to overcome the defects of poor mite removal effect or certain skin irritation in the prior art and provide a mite removal composition. The mite-killing composition provided by the invention is compounded by utilizing various plant extracts, contains natural plant components, is mild and non-irritating, has the synergistic effect of various active components, can play a good role in sterilizing and killing mites under the condition of low usage amount, and can also reduce the usage amount of preservatives in cosmetics and reduce the irritation to skin.
It is another object of the present invention to provide a method for preparing the mite-killing composition.
It is a further object of the present invention to provide the use of the mite-killing composition for preparing cosmetics.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
the mite-killing composition comprises the following components in parts by weight:
0.01 to 0.3 part of magnolol;
0.01 to 0.3 part of peach toposide;
0.1 to 2 portions of nano sulfur.
Honokiol, commonly found in magnolia bark of magnolia of magnoliaceae, is also known as 3, 5-di-2-propenyl-1, 1-biphenyl-2, 4-diol, is a tan to white fine powder, is dissolved in ethanol, propylene glycol, hexanediol and the like or alkaline medium, has broad-spectrum antibacterial effect, has stronger antibacterial property on gram-positive bacteria and gram-negative bacteria, has stable antibacterial property, is not easy to be damaged by heat, acid and alkali, and has the strongest inhibition effect on staphylococcus aureus; the inventor finds that the anti-mite agent also has better anti-mite and synergistic anti-mite effects.
The peach topol is commonly found in the arhat pine, is rich in aromatic diterpene, can inhibit peroxidation of grease, is a high-efficiency antibacterial agent, has better antibacterial effect on gram positive bacteria including streptococcus, bacillus subtilis, staphylococcus aureus, propionibacterium acnes and the like, and has no irritation and anaphylactic reaction to human skin. The inventor finds that the anti-mite agent also has a certain anti-mite and synergistic anti-mite effect.
The nanometer sulfur has the effects of killing scabies, bacteria and fungi, removing grease, softening epidermis and dissolving cutin, and the action mechanism is the result of generating hydrogen sulfide, dithionite and the like after the sulfur contacts skin and tissue secretion.
The inventor of the invention finds that by using magnolol, totarol and nano sulfur to carry out specific compounding, the composition obtained by compounding the magnolol, the totarol and the nano sulfur has better synergistic effect in the aspect of mite removal, contains natural plant components, is mild and does not irritate, and a plurality of active components have synergistic effect, so that the cosmetic can play a good role in sterilizing and removing mites under the condition of lower using amount, and can also reduce the using amount of preservatives in the cosmetic and reduce the irritation to skin. The nano sulfur can soften skin superfluous cutin, dredge pores, and the peach phenol can regulate grease secretion, and has synergistic effect with honokiol to achieve the effects of inhibiting bacteria and killing mites.
Preferably, the mite-killing composition comprises the following components in parts by weight:
0.015-0.15 part of honokiol;
0.015-0.15 part of peach toposide;
0.3 to 1.0 part of nano sulfur.
Further preferably, the mite-killing composition comprises the following components in parts by weight:
0.03 parts of honokiol;
0.08 part of peach toposide;
0.5 part of nano sulfur.
Preferably, the honokiol and the totarol are commercial raw materials, and the purity is more than 98%.
Preferably, the nano sulfur is nano biological sulfur.
Preferably, the nano biological sulfur is coated in a nano carrier.
Preferably, the nano-carrier is one or a combination of a plurality of lipoic acid, phospholipid and caprylic/capric triglyceride.
The nanometer sulfur can be suspended in colloid solution, has better diffusion and higher skin activity, and has no irritation to skin. The effect of the direct interaction of nano sulfur and skin depends on the particle size, and the larger the effective area of the interaction of sulfur and skin is, the larger the effect is.
Preferably, the particle size of the nano sulfur is 1-100 μm.
The preparation method of the mite-killing composition comprises the following steps: mixing the honokiol, the totarol, the nano sulfur and the water to obtain the mite-removing composition.
Preferably, the temperature of the mixing is 40-45 ℃.
Preferably, the mixing time is 30 to 40 minutes.
The mite-killing composition (or the dilution thereof (the mass fraction of the mite-killing composition is 0.2-3.0 wt%) can be directly sprayed on the skin.
The mite-killing composition can also be added into mite-killing products (such as cosmetics) as an effective component.
The use of the above-described mite-killing composition in the preparation of mite-killing products is also within the scope of the present invention.
Preferably, the mite-killing composition is added in an amount of 0.2-3.0 wt% in the mite-killing product.
Compared with the prior art, the invention has the following beneficial effects:
the mite-killing composition provided by the invention is compounded by utilizing various plant extracts, contains natural plant components, is mild and non-irritating, can play a good role in sterilizing and killing mites under the condition of low usage amount by the synergistic effect of the magnolol, the totarol and the nano sulfur, and can also reduce the usage amount of preservative in cosmetics and reduce the irritation to skin.
Detailed Description
The invention is further illustrated below with reference to examples. These examples are only for illustrating the present invention and are not intended to limit the scope of the present invention. The experimental procedures in the examples below, without specific details, are generally performed under conditions conventional in the art or recommended by the manufacturer; the raw materials, reagents and the like used, unless otherwise specified, are those commercially available from conventional markets and the like. Any insubstantial changes and substitutions made by those skilled in the art in light of the above teachings are intended to be within the scope of the invention as claimed.
The raw materials selected in each example and comparative example of the present invention are described below:
honokiol: HPH98, 98% pure, purchased from henna and broad biotechnology limited;
peach leaf phenol: wkq-05832 with purity not less than 98% and available from Sichuan Vickers biotechnology Co., ltd;
nano sulfur: nanoActive Sulfur from the Puri Biomedicine.
Examples 1 to 5 and comparative examples 1 to 3
The present example provides a series of the above mite-killing compositions, which are obtained by mixing magnolol, totarol, and nano sulfur according to the formulation in table 1.
The above mite-killing composition was diluted into a dilution liquid having a mass fraction of 2.0wt% to obtain the mite-killing composition dilutions of examples 1 to 5 and comparative examples 1 to 3.
Table 1 formulations (parts by weight, total weight 100 parts) of the mite-killing compositions of each of the examples and comparative examples
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Honokiol of honokiol | 0.01 | 0.015 | 0.03 | 0.15 | 0.3 | / | 0.03 | 0.03 |
| Peach-leaf alcohol | 0.01 | 0.015 | 0.08 | 0.15 | 0.3 | 0.08 | / | 0.08 |
| Nanometer sulfur | 0.1 | 0.3 | 0.5 | 1.0 | 2.0 | 0.5 | 0.5 | / |
。
Comparative example 4
The comparative example is a commercial kernel and mugwort mite-repellent spray.
Performance testing
The mite-killing compositions provided in each of the examples and comparative examples were tested as follows.
1. Mite removal effect: according to NY/T1151.2-2006, method for testing indoor efficacy of pesticides for pesticide registration sanitary purposes, evaluation part 2: mite killing effect test was carried out in mite killing and dispelling agent.
Wherein, the test group was sprayed with the dilutions of the mite-killing composition prepared in each of the examples and the comparative examples, and the blank control group was not subjected to any treatment.
Mite killing rate = number of dead test insects/number of test insects x 100%
The test results are shown in table 2:
table 2 results of mite-killing test for each of the dilutions of the mite-killing composition of each of the examples and comparative examples
As can be seen from Table 2, the mite-killing effect of the mite-killing composition provided by each embodiment of the invention is better, and the mite-killing rate of more than 95% can be achieved by compounding the components with lower dosage. From example 3 and comparative examples 1-3, it is evident that the composition has significantly reduced killing effect on mites in the absence of either honokiol, totarol or nano sulfur. Compared with the commercial mite-killing products, the effect is remarkable.
Those of ordinary skill in the art will recognize that the embodiments herein are intended to assist the reader in understanding the principles of the invention and should be understood that the scope of the invention is not limited to such specific statements and embodiments. Those of ordinary skill in the art can make various other specific modifications and combinations from the teachings of the present disclosure without departing from the spirit thereof, and such modifications and combinations remain within the scope of the present disclosure.
Claims (7)
1. The application of the mite-killing composition in preparing mite-killing products is characterized in that the mite-killing composition comprises the following components in parts by weight:
0.015-0.15 part of honokiol;
0.015-0.15 part of peach toposide;
0.3 to 1.0 part of nano sulfur;
the addition amount of the mite-killing composition in the mite-killing product is 0.2-3 wt%.
2. The use according to claim 1, characterized in that the mite-killing composition consists of the following components in parts by weight:
0.03 parts of honokiol;
0.08 part of peach toposide;
0.5 part of nano sulfur.
3. The use according to claim 1, wherein the nanosulfur in the mite-killing composition is nanosulfur.
4. The use according to claim 3, wherein the particle size of the nano-biological sulphur is 1-100 μm.
5. A process for the preparation of a mite-killing composition for use according to any one of claims 1 to 4, comprising the steps of: mixing the honokiol, the totarol and the nano sulfur to obtain the mite-removing composition.
6. The process according to claim 5, wherein the temperature of the mixing is 40 to 45 ℃.
7. The method according to claim 5, wherein the mixing time is 30 to 40 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011639501.6A CN112618395B (en) | 2020-12-31 | 2020-12-31 | Mite-killing composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011639501.6A CN112618395B (en) | 2020-12-31 | 2020-12-31 | Mite-killing composition and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112618395A CN112618395A (en) | 2021-04-09 |
| CN112618395B true CN112618395B (en) | 2023-08-29 |
Family
ID=75290172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011639501.6A Active CN112618395B (en) | 2020-12-31 | 2020-12-31 | Mite-killing composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112618395B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113208949A (en) * | 2021-05-11 | 2021-08-06 | 煜宠宠物(湖北)有限公司 | Shower gel for treating fungal dermatosis of pets and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011038797A1 (en) * | 2009-10-02 | 2011-04-07 | Beiersdorf Ag | Use of magnolol or honokiol as antibacterial, antimycotic, antiparasitic, or antiviral active ingredients |
| CN105055380A (en) * | 2015-09-15 | 2015-11-18 | 中国药科大学 | Application of totarol to preparation of drug for preventing and treating ischemic cerebral apoplexy |
| CN106581687A (en) * | 2016-12-22 | 2017-04-26 | 吉林大学 | Totarol antibacterial nano hydrogel with whey protein as matrix and preparation method thereof |
| CN107523453A (en) * | 2017-08-25 | 2017-12-29 | 张悦健 | Except mite liquid soap and preparation method thereof |
| CN111346023A (en) * | 2020-04-15 | 2020-06-30 | 广州立白企业集团有限公司 | Plant bacteriostatic composition, mouthwash containing composition and preparation method of mouthwash |
| CN111631993A (en) * | 2020-06-08 | 2020-09-08 | 广东芭薇生物科技股份有限公司 | Composition containing sophora flavescens and magnolia officinalis extracts and cosmetic using composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040156873A1 (en) * | 2003-02-10 | 2004-08-12 | Gupta Shyam K. | Topically Bioavailable Acne and Rosacea Treatment Compositions |
-
2020
- 2020-12-31 CN CN202011639501.6A patent/CN112618395B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011038797A1 (en) * | 2009-10-02 | 2011-04-07 | Beiersdorf Ag | Use of magnolol or honokiol as antibacterial, antimycotic, antiparasitic, or antiviral active ingredients |
| CN105055380A (en) * | 2015-09-15 | 2015-11-18 | 中国药科大学 | Application of totarol to preparation of drug for preventing and treating ischemic cerebral apoplexy |
| CN106581687A (en) * | 2016-12-22 | 2017-04-26 | 吉林大学 | Totarol antibacterial nano hydrogel with whey protein as matrix and preparation method thereof |
| CN107523453A (en) * | 2017-08-25 | 2017-12-29 | 张悦健 | Except mite liquid soap and preparation method thereof |
| CN111346023A (en) * | 2020-04-15 | 2020-06-30 | 广州立白企业集团有限公司 | Plant bacteriostatic composition, mouthwash containing composition and preparation method of mouthwash |
| CN111631993A (en) * | 2020-06-08 | 2020-09-08 | 广东芭薇生物科技股份有限公司 | Composition containing sophora flavescens and magnolia officinalis extracts and cosmetic using composition |
Non-Patent Citations (1)
| Title |
|---|
| 氧哥趣健康.简单洗个澡，肌肤白嫩、更明艳动人.《https://mp.weixin.qq.com/s?__biz=Mzg2MzQ1MDEzMQ==&mid=2247532246&idx=2&sn=65e13e62a6d6c03295d5856c02cd6de9&chksm=ce7a5baaf90dd2bce187b73e2d794f2070532190fb8f847d8de973c4925fbc75e7bfffa36b8c&mpshare=1&scene=1&srcid=02198Erm9jbdk3TKNd740B6l&sharer_sharetime=1676817446509&sharer_shareid=c8140a4780ab56e846b53516f3347d98&exportkey=n_ChQIAhIQgRPvhDUIRV5HxD1B%2BLUBfBLqAQIE97dBBAEAAAAAAPtYAaMU5SgAAAAOpnltbLcz9gKNyK89dVj0RdtRS21cui%2Fwr916MdfCKLvLab%2FUIzvxrzIr8T3lzFd9zmI%2FE3tQU9oSBX1t%2Bqr5r3ZH1DiHdx6zc%2BMfsvLfmCSZy7dhGulrXoft%2Fk1uMTYXJvPF%2FWbu7Nr39Ww6jDqRiWM44b%2BhuYGRq8oYpnNvM184dpa7IRvq1HRJeO1Q4AIOJtgI0Qv5pKZmPrRNi9AOMPLXnsChbOhoD87xfnHkLctUOP7MVpO7p72HyUqMcx9Wtx9G5%2B1phaNY%2FlKE64CrZ4I4FQ%3D%3D&acctmode=0&pass_ticket=ldoCsebHBJRIgMV%2B6s%2BG5THVGHL%2B%2B6zR41Tr7%2Bd1TOFutc2Tu1gzpOsVMrojBww6rMuRYLKjEdDThG%2FF6%2F9MOQ%3D%3D&wx_header=0#rd》.2020,正文. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112618395A (en) | 2021-04-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8309143B2 (en) | Hair and scalp care formulations for treating and preventing acne and related skin conditions | |
| US20080045491A1 (en) | Surface sanitizer | |
| US6123953A (en) | Cosmetic, dermopharmaceutical or veterinary compositions for disinfecting human or animal skin | |
| US6248343B1 (en) | Therapeutic antimicrobial compositions | |
| EP2387883B1 (en) | Antimicrobial compositions comprising benzoic acid | |
| JP2015501330A (en) | Antibacterial composition, healing composition, cleaning composition, anti-fungal topical cream, edible antiseptic cleanser, surface antiseptic, insecticide | |
| US8741271B2 (en) | Antimicrobial compositions containing essential oils | |
| US11826393B2 (en) | Ointment-based skin wound treatment method | |
| CN108078863B (en) | Bactericidal composition based on plant extracts and infant care composition | |
| CN112618395B (en) | Mite-killing composition and preparation method and application thereof | |
| KR102069297B1 (en) | Female clenaser composition | |
| CN106726742B (en) | Two-phase scalp care composition without emulsifier | |
| CN116602896B (en) | Natural plant preservative effect self-microemulsified liquid and preparation method thereof | |
| KR102163976B1 (en) | trifoliate orange extracted by Tincture How to make odor reducing animal shampoo using this | |
| CN111067866A (en) | Wash-free ethanol hand disinfection spray | |
| KR102421688B1 (en) | Antibacterial functional cosmetic composition for anti-oxidation, anti-inflammatory and anti-aging having gardenia floride flower extract, pelargonium graveolens extract and salvia officinalis extract | |
| CN1194662C (en) | Nim cosmetics series based on active component of nim for daily use and its preparing process | |
| EP2252155B1 (en) | Method for minimizing the cytotoxicity of the effective agent inhibiting the growth of micro-organisms and for maximizing the effect | |
| DE60005530T2 (en) | ANTISEPTIC COMPOSITIONS | |
| US7189421B2 (en) | Antiseptic composition | |
| CN106691895A (en) | Antiperspirant for preventing and treating bromhidrosis and preparation method of antiperspirant | |
| RU2118152C1 (en) | Cosmetic cream for prophylaxis of skin mycosis "rada-plus" | |
| JP4284305B2 (en) | Deodorant active agent and composition for external application for deodorizing skin | |
| KR20050034271A (en) | Antimicrobial composition containing natural extract, nano silver and natural essential oil | |
| JPH0536404B2 (en) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |