CN113208949A - Shower gel for treating fungal dermatosis of pets and preparation method thereof - Google Patents

Abstract

The invention discloses a shower gel for treating fungal skin diseases of pets and a preparation method thereof, belonging to the technical field of pet products, comprising 68.65-82.74% of water, 10-14% of sodium lauryl polyoxyethylene ether sulfate, 1.5-3% of coconut diethanolamide, 2-4% of cocoamidopropyl betaine, 0.5-1.5% of decyl glucoside, 1-3% of glycerol, 0.1-0.2% of disodium ethylenediamine tetraacetate, 0.25-0.45% of maltodextrin, 0.1-0.3% of menthol, 1.0-1.5% of citric acid, 0.1-0.2% of kasong, 0.1-0.5% of essence, 0.4-2.2% of sodium chloride, 0.2-0.4% of PEG-7 glyceryl cocoate, and 0.01-0.1% of nano sulfur No toxicity and no drug resistance.

Description

Shower gel for treating fungal dermatosis of pets and preparation method thereof

Technical Field

The invention relates to the technical field of pet products, in particular to shower gel for treating fungal skin diseases of pets and a preparation method thereof.

Background

With the steady increase of national economy, the superposition of urbanization development and policy influence of solitary children and the gradual increase of social aging degree, the pet breeding is selected to increase comfort feeling, and the pet breeding method becomes a life style of the tendency of the nation. But the skin disease incidence rate of the pet is high, the clinical treatment time is long, the repeated treatment is easy, and the health of the pet is harmed. Although the disease does not cause death of the pet for a short time, the ornamental value and the economic value of the pet are reduced.

Pet dermatosis is often caused by fungi, and is caused by excessive adhesion, reproduction and invasion of pathogenic bacteria of pet dermatomycosis to skin tissues and causes a series of organic lesions of the skin. Various skin diseases caused by fungi parasitizing in pet fur and cutin tissues of body surfaces and toe claws are generally called dermatomycosis, and are characterized in that depilatory round spots with obvious boundaries appear on the skin, potential skin injury, exudate, scales or scabs, itching and the like are caused. The disease is commonly suffered by human and animals, and the human and animal diseases are called tinea in the medical science, and occur in all countries in the world. It is manifested as local or systemic alopecia, desquamation. Secondary bacterial infection can form tinea purulent, which has long course, is difficult to cure and easy to recur, and can be mutually transmitted among animals, people and people to cause public health problems to a certain extent.

About 98% of world-wide feline dermatophytosis pathogens are microsporidia canis, 1% each of microsporidia gypseum and trichophyton mentagrophytes. Canine dermatomycosis is 70% caused by Microsporum canis, 20% by weight of Microsporum gypseum and 10% by weight of Trichophyton mentagrophytes.

Treating general dermatomycosis with topical therapeutic agent or combined systemic therapeutic agent. Clinical findings show that topical therapeutic agents work well in the early stages of disease onset, in most cases. Topical therapeutic drugs kill fungi or inhibit the proliferation of fungi by altering the local microenvironment of the skin. The use of topical prophylactic drugs is of interest for the prevention of relapse of old disease. Many different topical therapeutic agents and formulations, such as shampoos, infusions, creams, lotions and the like, work well.

The pet shampoo has the combined functions of cleaning, antibiosis and antiphlogosis, has fragrant smell, and is more and more favored by the market.

At present, most of the medicines added in the lotion or infusion for treating the pet dermatomycosis are insecticides, such as pyrethroid pesticides, ivermectin, terbinafine hydrochloride and the like, and although the toxicity to pets is low, the medicines always have certain toxicity; the infection of drug-resistant bacteria is serious at present and an effective means is lacked. Antibiotics and antifungal drugs are very easy to generate drug resistance, and the antifungal drugs are generally used for a long time, such as two to four weeks. The long-term administration obviously causes damage to the mind and body of the pet. Moreover, the skin diseases are still often chronic, with insignificant or recurrent effects after administration. Compared with the treatment products, the traditional Chinese medicine compound lotion or shampoo for treating pet dermatomycosis can reduce toxicity, avoid drug-resistant bacteria, sacrifice part of sterilization rate and prolong treatment course.

Disclosure of Invention

1. Technical problem to be solved

Aiming at the problems in the prior art, the invention aims to provide the shower gel for treating the fungal dermatosis of the pet and the preparation method thereof, which can realize high sterilization rate, actual non-toxicity and no drug resistance aiming at the fungal dermatosis.

2. Technical scheme

In order to solve the above problems, the present invention adopts the following technical solutions.

The shower gel for treating the fungal dermatosis of pets comprises the following components in percentage by weight:

68.65-82.74 percent of water

10-14% of sodium lauryl polyoxyethylene ether sulfate

Coconut oil diethanolamide 1.5-3%

Coconut oil amide propyl betaine 2% -4%

Decyl glucoside 0.5% -1.5%

1 to 3 percent of glycerin

0.1 to 0.2 percent of disodium ethylene diamine tetraacetate

0.25 to 0.45 percent of maltodextrin

Menthol 0.1-0.3%

1.0 to 1.5 percent of citric acid

0.1 to 0.2 percent of cason

0.1 to 0.5 percent of essence

0.4 to 2.2 percent of sodium chloride

PEG-7 glycerol cocoate 0.2% -0.4%

0.01 to 0.1 percent of nano sulfur.

Further, the sodium lauryl polyoxyethylene ether sulfate salt can be replaced by lauryl polyoxyethylene ether ammonium sulfate, and the coconut diethanolamide can be replaced by coconut fatty acid monoethanolamide or coconut methyl monoethanolamine.

Further, the cocamidopropyl betaine may be replaced by dodecyl dimethyl aminoethylenolactone, and decyl glucoside may be replaced by sodium lauroyl sarcosinate.

Further, the glycerol may be replaced with propylene glycol.

Furthermore, the disodium ethylene diamine tetraacetate can be replaced by one of tetrasodium ethylene diamine tetraacetate and tetrasodium glutamate diacetate.

Further, the maltodextrin can be replaced by bentonite or guar gum hydroxypropyl trimethyl ammonium chloride, and the menthol can be replaced by borneol.

Further, the citric acid can be replaced by lactic acid, and the cason can be replaced by any one of phenoxyethanol, ethylparaben and potassium sorbate.

Further, the sodium chloride may be replaced by potassium chloride, and the PEG-7 glyceryl cocoate may be replaced by aqueous lanolin.

The preparation method of the shower gel for treating the fungal skin disease of the pet is used for preparing the shower gel for treating the fungal skin disease of the pet, and comprises the following steps:

(1) respectively weighing water and disodium ethylene diamine tetraacetate according to the mass percentage, and stirring until the water and the disodium ethylene diamine tetraacetate are fully dissolved to obtain clear liquid;

(2) respectively weighing sodium lauryl polyoxyethylene ether sulfate, coconut diethanolamide, coconut amidopropyl betaine, menthol, decyl glucoside, PEG-7 glyceryl cocoate and maltodextrin according to the mass percentage, adding into the liquid obtained in the step (1), heating to 55 ℃, and stirring until the mixture is fully dissolved to obtain clear liquid;

(3) after the liquid obtained in the step (2) is kept stand and cooled to room temperature, weighing citric acid according to the mass percentage and adding the citric acid, and adjusting the pH value to 6.3-6.6;

(4) weighing the kaempferia, the essence and the nano sulfur according to the mass percentage, adding the kaempferia, the essence and the nano sulfur into the liquid obtained in the step (3), and stirring until the components are fully dissolved to obtain clear liquid;

(5) and (4) weighing sodium chloride according to the mass percent, adding the sodium chloride into the liquid obtained in the step (4), and fully stirring until the viscosity of the sodium chloride does not change any more, so as to obtain colorless, clear and viscous liquid.

The nano sulfur is prepared by the following method:

s1: according to the mass ratio of 1: (1.225-8.6) weighing sulfur powder with the particle size of 20-100 mu m and water respectively, pouring the sulfur powder into a container, and dispersing for 20-30 minutes by using an emulsifying machine with the rotation speed of 10000 and 28000 rpm;

s2: pouring the slurry prepared in the step S1 into a ball milling tank, and adding a ball milling medium, a dispersing agent and a heat stabilizer, wherein the addition amounts of the ball milling medium, the dispersing agent and the heat stabilizer are respectively 5-8 times of the mass of the sulfur powder; 2 to 6 percent of dispersant; 2-5% of heat stabilizer, and sealing the ball milling tank;

s3: placing the ball milling tank on a ball mill with the rotation speed of 300-500rpm, and performing dispersion milling for 5-10 hours

S4: removing granular impurities which are not dispersed after ball milling in the sulfur slurry by using a vacuum suction filter with the filtering mesh number of 600 meshes, and recovering to prepare the nano sulfur slurry with the grain diameter of 5nm-100 nm.

3. Advantageous effects

Compared with the prior art, the invention has the advantages that:

(1) according to the scheme, a basic shampoo system is constructed by using lauryl polyoxyethylene ether sulfate sodium salt, coconut oil diethanolamide, cocamidopropyl betaine and sodium chloride, and sunflower-based glucoside, glycerin, PEG-7 glyceryl cocoate, menthol, maltodextrin, nano sulfur and other raw materials are added into the shampoo system, so that the shampoo system has the functions of enabling the skin to be mild, moisturizing, preventing grease from drying, enabling the skin to be cool and not greasy, nourishing and moistening, sterilizing in a broad spectrum, resisting bacteria for a long time, killing mites and killing insects and the like.

(2) The nano-sulfur is practically nontoxic, the dosage is low, the broad-spectrum sterilization rate is high, and the nano-sulfur has the remarkable effect on scabies, tinea pedis, dorsal furuncle, malignant boil and skin pruritus.

(3) The shampoo matrix has mild skin feel, moisture retention, fat and dry prevention, cool and non-greasy skin feel, and nutrition and moistening.

Drawings

FIG. 1 is a graph showing the relationship between the bacterial killing rate and the particle size of a nano sulfur solution according to the present invention;

FIG. 2 is a graph showing the relationship between the bacterial killing rate and the concentration of the nano sulfur solution in the present invention;

FIG. 3 shows a sample of the present invention after 5 minutes of non-treatment;

FIG. 4 shows a sample of the bacteria treated for 5 minutes in the present invention;

FIG. 5 shows the samples treated for 20h in the present invention.

Detailed Description

The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention; it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work are within the scope of the present invention.

The shower gel for treating the fungal dermatosis of pets comprises the following components in percentage by weight:

68.65-82.74 percent of water

10-14% of sodium lauryl polyoxyethylene ether sulfate

Coconut oil diethanolamide 1.5-3%

Coconut oil amide propyl betaine 2% -4%

Decyl glucoside 0.5% -1.5%

1 to 3 percent of glycerin

0.1 to 0.2 percent of disodium ethylene diamine tetraacetate

0.25 to 0.45 percent of maltodextrin

Menthol 0.1-0.3%

1.0 to 1.5 percent of citric acid

0.1 to 0.2 percent of cason

0.1 to 0.5 percent of essence

0.4 to 2.2 percent of sodium chloride

PEG-7 glycerol cocoate 0.2% -0.4%

0.01 to 0.1 percent of nano sulfur

Specifically, the sodium lauryl polyoxyethylene ether sulfate can be replaced by lauryl polyoxyethylene ether ammonium sulfate, and the latter has more abundant foams than the former and higher market price;

coconut oil diethanolamide can be replaced by coconut oil fatty acid monoethanolamide or coconut oil methyl monoethanolamine, and compared with the coconut oil fatty acid monoethanolamide and the coconut oil methyl monoethanolamine, the harm of diethanolamine to organisms is eliminated, the phenomenon of jelly does not occur at low temperature, and the market price is higher.

Specifically, the cocamidopropyl betaine can be replaced by dodecyl dimethyl aminoethylenolactone, and compared with the latter, the former has an amido bond, is easier to degrade, is milder to skin and has small irritation;

decyl glucoside can be replaced by sodium lauroyl sarcosine, and the surface activity of the two amino acids is milder than that of common skin cleaning.

In particular, the glycerol may be replaced by propylene glycol, the former having less effect on the viscosity of the system than the latter.

Specifically, the disodium ethylene diamine tetraacetate can be replaced by one of tetrasodium ethylene diamine tetraacetate and tetrasodium glutamate diacetate, the market price of the disodium ethylene diamine tetraacetate and the tetrasodium glutamate diacetate is lower than that of the disodium ethylene diamine tetraacetate and the tetrasodium glutamate diacetate, the chelating force is weaker, and the protection on the cleaning force of an anionic surfactant is weaker.

Specifically, the maltodextrin can be replaced by bentonite or guar gum hydroxypropyl trimethyl ammonium chloride and is used as an auxiliary thickener, the market price of the bentonite or guar gum hydroxypropyl trimethyl ammonium chloride is lower than that of the auxiliary thickener, and the maltodextrin is rich in vitamin D and vitamin E and has certain skin moistening effect;

the menthol can be replaced by borneol, and the former has lower toxicity than the latter when taken orally.

Specifically, the citric acid can be replaced by lactic acid, and the latter has larger smell than the former;

the cason can be replaced by any one of phenoxyethanol, ethylparaben and potassium sorbate, is used as a preservative, and when the three are used singly, the comprehensive preservative effect on common bacteria and fungi, especially mould is not as good as that of the cason, and needs to be compounded.

Specifically, the sodium chloride can be replaced by potassium chloride, and a strong electrolyte can be used;

PEG-7 glyceryl cocoate can be replaced by aqueous lanolin, the former has less influence on foam, lower viscosity, better ductility and better skin permeability than the latter. Meanwhile, the skin care product has the effects of conditioning functions and moistening the skin.

The preparation method of the shower gel for treating the fungal skin disease of the pet is used for preparing the shower gel for treating the fungal skin disease of the pet, and comprises the following steps:

(1) respectively weighing water and disodium ethylene diamine tetraacetate according to the mass percentage, and stirring until the water and the disodium ethylene diamine tetraacetate are fully dissolved to obtain clear liquid;

(2) respectively weighing sodium lauryl polyoxyethylene ether sulfate, coconut diethanolamide, coconut amidopropyl betaine, menthol, decyl glucoside, PEG-7 glyceryl cocoate and maltodextrin according to the mass percentage, adding into the liquid obtained in the step (1), heating to 55 ℃, and stirring until the mixture is fully dissolved to obtain clear liquid;

(3) after the liquid obtained in the step (2) is kept stand and cooled to room temperature, weighing citric acid according to the mass percentage and adding the citric acid, and adjusting the pH value to 6.3-6.6;

(4) weighing the kaempferia, the essence and the nano sulfur according to the mass percentage, adding the kaempferia, the essence and the nano sulfur into the liquid obtained in the step (3), and stirring until the components are fully dissolved to obtain clear liquid;

(5) and (4) weighing sodium chloride according to the mass percent, adding the sodium chloride into the liquid obtained in the step (4), and fully stirring until the viscosity of the sodium chloride does not change any more, so as to obtain colorless, clear and viscous liquid.

Phenomena that can occur during preparation:

before the shampoo preparation step (3), the shampoo can be completely dissolved after being heated and stirred fully so as to clarify the liquid; the mixture in the step (4) becomes milky turbid after the three raw materials are added, and is fully stirred until the mixture is solubilized and clarified; and (5) thickening the liquid after adding strong electrolyte.

And the nano sulfur is prepared by the following method:

s1: according to the mass ratio of 1: (1.225-8.6) weighing sulfur powder with the particle size of 20-100 mu m and water respectively, pouring the sulfur powder into a container, and dispersing for 20-30 minutes by using an emulsifying machine with the rotation speed of 10000 and 28000 rpm;

s2: pouring the slurry prepared in the step S1 into a ball milling tank, and adding a ball milling medium, a dispersing agent and a heat stabilizer, wherein the addition amounts of the ball milling medium, the dispersing agent and the heat stabilizer are respectively 5-8 times of the mass of the sulfur powder; 2 to 6 percent of dispersant; 2-5% of heat stabilizer, and sealing the ball milling tank;

s3: placing the ball milling tank on a ball mill with the rotation speed of 300-500rpm, and performing dispersion milling for 5-10 hours

S4: removing granular impurities which are not dispersed after ball milling in the sulfur slurry by using a vacuum suction filter with the filtering mesh number of 600 meshes, and recovering to prepare the nano sulfur slurry with the grain diameter of 5nm-100 nm.

Experimental or testing data

Experimental example 1:

taking 0.01% of nano sulfur, 10% of sodium lauryl polyoxyethylene ether sulfate, 1.5% of coconut diethanolamide, 2% of cocoamidopropyl betaine, 0.5% of decyl glucoside, 1% of glycerol, 0.1% of disodium ethylene diamine tetraacetate, 0.25% of maltodextrin, 0.1% of menthol, 1.0% of citric acid, 0.1% of kasong, 0.1% of essence, 0.4% of sodium chloride, 0.2% of PEG-7 glyceryl cocoate and the balance of water.

The preparation method comprises the following steps: the same experiment method is adopted.

The using method comprises the following steps: adding 160ml of water into 40ml of shampoo, uniformly mixing, fully wetting the sick pet, smearing the mixed solution on the surface of the hair of the sick pet, fully rubbing the pet until the pet permeates into the epidermis, staying for 3-5 minutes, and then washing the pet with clear water; 1 time per day. The medicine is used for 3-5 days for patients with mild symptoms; it is used for 5-7 days in combination for patients with severe symptoms.

And (3) counting the curative effect: the shampoo is used for treating 15 cases of sick skin cats and dogs, 7 cases are cured, and the cure rate is 46%.

And (3) knotting: although the scheme is the lowest, the cleaning power is weak, the viscosity is low, the fragrance is weak, the product is lack of experience in use, and the concentration of the nano sulfur does not reach the effective sterilization range, so that the cure rate is low.

Experimental example 2:

taking 0.1% of nano sulfur, 14% of sodium lauryl polyoxyethylene ether sulfate, 3% of coconut diethanolamide, 4% of cocoamidopropyl betaine, 1.5% of decyl glucoside, 3% of glycerol, 0.2% of disodium ethylene diamine tetraacetate, 0.45% of maltodextrin, 0.3% of menthol, 1.5% of citric acid, 0.2% of kasong, 0.5% of essence, 2.2% of sodium chloride, 0.4% of PEG-7 glyceryl cocoate and the balance of water.

The preparation method comprises the following steps: the same experiment method is adopted.

The using method comprises the following steps: adding 160ml of water into 40ml of shampoo, uniformly mixing, fully wetting the sick pet, smearing the mixed solution on the surface of the hair of the sick pet, fully rubbing the pet until the pet permeates into the epidermis, staying for 3-5 minutes, and then washing the pet with clear water; 1 time per day. The medicine is used for 3-5 days for patients with mild symptoms; it is used for 5-7 days in combination for patients with severe symptoms.

And (3) counting the curative effect: the shampoo is used for treating 15 cases of sick skin cats and dogs, 13 cases are cured, and the cure rate is 86%.

And (3) knotting: the scheme has high cure rate, but the nano sulfur in the product is separated out to cause the product to turn milk white, and the nano sulfur is easily delaminated after long-term storage to cause the nano sulfur to be settled, so that the concentration distribution is not uniform when the nano sulfur is used, and the local concentration is low to influence the sterilization rate, thereby causing the cure rate not to reach the expected index.

Experimental example 3:

taking 0.05% of nano sulfur, 12% of sodium lauryl polyoxyethylene ether sulfate, 2% of coconut diethanolamide, 3% of cocamidopropyl betaine, 1% of decyl glucoside, 2% of glycerol, 0.15% of disodium ethylene diamine tetraacetate, 0.3% of maltodextrin, 0.2% of menthol, 1.115% of citric acid, 0.15% of kason, 0.3% of essence, 1.658% of sodium chloride, 0.3% of PEG-7 glyceryl cocoate and the balance of water.

The preparation method comprises the following steps: the same experiment method is adopted.

The using method comprises the following steps: adding 160ml of water into 40ml of shampoo, uniformly mixing, fully wetting the sick pet, smearing the mixed solution on the surface of the hair of the sick pet, fully rubbing the pet until the pet permeates into the epidermis, staying for 3-5 minutes, and then washing the pet with clear water; 1 time per day; the medicine is used for 3-5 days for patients with mild symptoms; it is used for 5-7 days in combination for patients with severe symptoms.

And (3) counting the curative effect: the shampoo is used for treating 15 cases of sick skin cats and dogs, 11 cases are cured, and the cure rate is 73%.

And (3) knotting: the scheme has the advantages of high cure rate, transparent product, viscosity of more than 4000mPa & s, smooth hand feeling, mild skin feeling, rich foam and mild and abundant fragrance when in use.

Experimental example 4:

taking 0.08% of nano sulfur, 12% of sodium lauryl polyoxyethylene ether sulfate, 2% of coconut diethanolamide, 3% of cocamidopropyl betaine, 1% of decyl glucoside, 2% of glycerol, 0.15% of disodium ethylene diamine tetraacetate, 0.3% of maltodextrin, 0.2% of menthol, 1.115% of citric acid, 0.15% of kason, 0.3% of essence, 1.658% of sodium chloride, 0.3% of PEG-7 glyceryl cocoate and the balance of water.

The preparation method comprises the following steps: the same experiment method is adopted.

The using method comprises the following steps: adding 160ml of water into 40ml of shampoo, uniformly mixing, fully wetting the sick pet, smearing the mixed solution on the surface of the hair of the sick pet, fully rubbing the pet until the pet permeates into the epidermis, staying for 3-5 minutes, and then washing the pet with clear water; 1 time per day; the medicine is used for 3-5 days for patients with mild symptoms; it is used for 5-7 days in combination for patients with severe symptoms.

And (3) counting the curative effect: the shampoo is used for treating 15 cases of sick skin cats and dogs, 14 cases are cured, and the cure rate is 93%.

And (3) knotting: the scheme has the advantages of higher cure rate, transparent product, viscosity of more than 4000mPa & s, smooth hand feeling, mild skin feeling, rich foam and mild and abundant fragrance when in use.

The nano-scale sulfur has good insecticidal, acaricidal and bactericidal effects as the traditional sulfur; has selectivity to spores of powdery mildew, selective toxicity to mites, and can be used for killing mite; the traditional sulfur exists in a large particle state and is difficult to configure into a required concentration; the sulfur granules are made into colloid with the grain diameter of less than 60mm, so the use is convenient, and the effect can be exerted with the minimum concentration.

The nano sulfur solution (20 nm) is delivered to a third-party detection mechanism SGS for disinfection and sterilization effect testing, the evaluation method and the standard of GB15981-1995 disinfection and sterilization effects are adopted for testing, and escherichia coli 8099 is adopted as an experimental strain. The results of the specific tests (no neutralizing agent used in the test) are shown in table 1:

TABLE 1 bacterial kill rate of nano-sulfur solution (20 nm)

As can be seen from the test results in Table 1, the nano sulfur solution has good disinfection and sterilization effects, and the killing rate of the original solution on Escherichia coli 8099 can still reach more than 98.5% after the original solution is diluted by 5 times.

Analysis of influence of particle size on antibacterial effect

Several nano-level sulfur solutions are selected for disinfection and sterilization tests, and escherichia coli 8099 is taken as an experimental strain. Each stock was diluted 5-fold over the stock and the results of the specific tests (no neutralizer used in the test) are shown in figure 1:

as can be seen from FIG. 1, as the particle size increases, the killing rate of the nano sulfur liquid correspondingly decreases gradually, and it can be deduced that the particle size has a great influence on the killing rate of sulfur, and the smaller the particle size is, the more ideal the sterilization effect is; the larger the particle size, the lower the sterilization rate, when the particle size is less than or equal to 20nm, the killing rate is slightly increased with the decrease of the particle size, but the difference is smaller, when the particle size is in the range of 20nm-60nm, the killing rate can be kept about 98%, and the particle size in the section is smaller, so that the ideal sterilization effect can be achieved.

Analysis of influence of concentration on antibacterial effect of nano sulfur liquid

Selecting several nano sulfur solutions with different concentrations for disinfection and sterilization test, and adopting Escherichia coli 8099 as experimental strain; each stock was diluted 5-fold over the stock and the results of the specific tests (no neutralizer used in the test) are shown in fig. 2:

as can be seen from FIG. 2, the killing rate of the nano sulfur liquid is correspondingly reduced gradually with the increase of the concentration, it can be deduced that the concentration has great influence on the sterilization rate of the sulfur, and the greater the concentration is, the more ideal the sterilization effect is; the smaller the concentration is, the lower the sterilization rate is, when the concentration is more than or equal to 90ppm, the sterilization rate is slightly increased, but the difference is small, and when the concentration is in the range of 90ppm-100ppm, the sterilization rate can be kept about 98.5, and the ideal sterilization effect can be achieved.

Analysis of influence of killing time on antibacterial effect of nano sulfur liquid

Culturing bacterial colony in a plate by the same method, and testing the antibacterial property of the nano sulfur solution, wherein the specific effect graphs are shown in figures 3-5;

as can be seen from the graphs in FIGS. 3-5, the nano sulfur solution can not achieve a strong sterilization effect in a short time, and can achieve a significant sterilization effect after being treated for 20 hours.

Summary of experimental data: according to the microbial detection report and clinical use results of the product added with the nano sulfur, the broad spectrum sterilization efficiency is rapidly increased from 50% when the concentration of the nano sulfur is between 0.01 and 0.05%, and the broad spectrum sterilization rate is gradually increased from 97.5% to 98.9% when the concentration of the nano sulfur is between 0.08 and 0.1%, but the nano sulfur is difficult to be solubilized and is easy to precipitate after the concentration of the nano sulfur exceeds 0.08%, so that the system stability is reduced; continue to increase to 0.13% infinitely close to 99%; as shown by feedback evaluation of clinical usage products in pet stores, the usage feeling provided by the formula ratios in example 4 is more consistent with the needs of the public, and the price compromise is more acceptable.

The optimal proportion of the product can be obtained in the following steps:

name of raw materials	Mass percent
		Water (W)	75.797％
Sodium lauryl polyoxyethylene ether sulfate	12.000％
		Coconut oil diethanolamide	2.000％
Cocos oil amidopropyl betaine	3.000％
		Decyl glucoside	1.000％
Glycerol	2.000％
		Ethylenediaminetetraacetic acid disodium salt	0.150％
Maltodextrin	0.300％
		Menthol crystal	0.200％
Citric acid	1.115％
		Kathon	0.100％
Essence	0.300％
		Sodium chloride	1.658％
PEG-7 Glycerol cocoate	0.300％
		Nano sulfur	0.080％

In the above examples, the base material can be replaced by the above-mentioned alternative material, and the range of the use ratio is approximately similar to the range of the original product recommended ratio, so that the product cost is increased, but the use feeling of the product is not greatly improved.

The invention has the characteristics that:

(1) the nano sulfur is actually nontoxic, the dosage is low, the broad-spectrum sterilization rate is high, and the nano sulfur on the surface of the literature has the remarkable effect on scabies, tinea pedis, dorsal furuncle, malignant boil and skin pruritus;

(2) the shampoo matrix has mild skin feel, can keep moisture, can make the skin feel cool and not greasy, and is nutritious and moist;

(3) when the dosage of the nano sulfur is too high, the shampoo is turbid.

Where applicable: treating various pets with skin diseases, especially skin diseases caused by fungi. Prevent mite protection and insect prevention. The formula is mild, the degreasing power is moderate, and the product can be used by people, not only can be used as bath cream, but also can be used as shampoo, and has excellent effects of removing mites, lice and fleas.

The foregoing is only a preferred embodiment of the present invention; the scope of the invention is not limited thereto. Any person skilled in the art should be able to cover the technical scope of the present invention by equivalent or modified solutions and modifications within the technical scope of the present invention.

Claims (10)

1. The shower gel for treating the fungal dermatosis of pets is characterized in that: the composition comprises the following components in percentage by weight:

68.65-82.74 percent of water

10-14% of sodium lauryl polyoxyethylene ether sulfate

Coconut oil diethanolamide 1.5-3%

Coconut oil amide propyl betaine 2% -4%

Decyl glucoside 0.5% -1.5%

1 to 3 percent of glycerin

0.1 to 0.2 percent of disodium ethylene diamine tetraacetate

0.25 to 0.45 percent of maltodextrin

Menthol 0.1-0.3%

1.0 to 1.5 percent of citric acid

0.1 to 0.2 percent of cason

0.1 to 0.5 percent of essence

0.4 to 2.2 percent of sodium chloride

PEG-7 glycerol cocoate 0.2% -0.4%

0.01 to 0.1 percent of nano sulfur.

2. The shower gel for treating fungal skin diseases of pets according to claim 1, wherein: the sodium lauryl polyoxyethylene ether sulfate can be replaced by lauryl polyoxyethylene ether ammonium sulfate, and the coconut oil diethanolamide can be replaced by coconut oil fatty acid monoethanolamide or coconut oil methyl monoethanolamine.

3. The shower gel for treating fungal skin diseases of pets according to claim 1, wherein: the cocamidopropyl betaine can be replaced by dodecyl dimethyl amine ethyl lactone, and decyl glucoside can be replaced by sodium lauroyl sarcosinate.

4. The shower gel for treating fungal skin diseases of pets according to claim 1, wherein: the glycerol may be replaced with propylene glycol.

5. The shower gel for treating fungal skin diseases of pets according to claim 1, wherein: the disodium ethylene diamine tetraacetate can be replaced by one of tetrasodium ethylene diamine tetraacetate and tetrasodium glutamate diacetate.

6. The shower gel for treating fungal skin diseases of pets according to claim 1, wherein: the maltodextrin can be replaced by bentonite or guar gum hydroxypropyl trimethyl ammonium chloride, and the menthol can be replaced by borneol.

7. The shower gel for treating fungal skin diseases of pets according to claim 1, wherein: the citric acid can be replaced by lactic acid, and the cason can be replaced by any one of phenoxyethanol, ethylparaben and potassium sorbate.

8. The shower gel for treating fungal skin diseases of pets according to claim 1, wherein: the sodium chloride can be replaced by potassium chloride, and the PEG-7 glyceryl cocoate can be replaced by aqueous lanolin.

9. A preparation method of the shower gel for treating the fungal skin disease of the pet, which is used for preparing the shower gel for treating the fungal skin disease of the pet, is characterized by comprising the following steps:

(1) respectively weighing water and disodium ethylene diamine tetraacetate according to the mass percentage, and stirring until the water and the disodium ethylene diamine tetraacetate are fully dissolved to obtain clear liquid;

(2) respectively weighing sodium lauryl polyoxyethylene ether sulfate, coconut diethanolamide, coconut amidopropyl betaine, menthol, decyl glucoside, PEG-7 glyceryl cocoate and maltodextrin according to the mass percentage, adding into the liquid obtained in the step (1), heating to 55 ℃, and stirring until the mixture is fully dissolved to obtain clear liquid;

(3) after the liquid obtained in the step (2) is kept stand and cooled to room temperature, weighing citric acid according to the mass percentage and adding the citric acid, and adjusting the pH value to 6.3-6.6;

(4) weighing the kaempferia, the essence and the nano sulfur according to the mass percentage, adding the kaempferia, the essence and the nano sulfur into the liquid obtained in the step (3), and stirring until the components are fully dissolved to obtain clear liquid;

(5) and (4) weighing sodium chloride according to the mass percent, adding the sodium chloride into the liquid obtained in the step (4), and fully stirring until the viscosity of the sodium chloride does not change any more, so as to obtain colorless, clear and viscous liquid.

10. The preparation method of the shower gel for treating the fungal skin disease of the pet, according to claim 9, is characterized in that the nano sulfur is prepared by the following method:

s1: according to the mass ratio of 1: (1.225-8.6) weighing sulfur powder with the particle size of 20-100 mu m and water respectively, pouring the sulfur powder into a container, and dispersing for 20-30 minutes by using an emulsifying machine with the rotation speed of 10000 and 28000 rpm;

s2: pouring the slurry prepared in the step S1 into a ball milling tank, and adding a ball milling medium, a dispersing agent and a heat stabilizer, wherein the addition amounts of the ball milling medium, the dispersing agent and the heat stabilizer are respectively 5-8 times of the mass of the sulfur powder; 2 to 6 percent of dispersant; 2-5% of heat stabilizer, and sealing the ball milling tank;

s3: placing the ball milling tank on a ball mill with the rotation speed of 300-;

s4: removing granular impurities which are not dispersed after ball milling in the sulfur slurry by using a vacuum suction filter with the filtering mesh number of 600 meshes, and recovering to prepare the nano sulfur slurry with the grain diameter of 5nm-100 nm.

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