CN112618395A - Mite killing composition and preparation method and application thereof - Google Patents
Mite killing composition and preparation method and application thereof Download PDFInfo
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- CN112618395A CN112618395A CN202011639501.6A CN202011639501A CN112618395A CN 112618395 A CN112618395 A CN 112618395A CN 202011639501 A CN202011639501 A CN 202011639501A CN 112618395 A CN112618395 A CN 112618395A
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- mite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Birds (AREA)
- Epidemiology (AREA)
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- Inorganic Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a mite-killing composition and a preparation method and application thereof. The mite removing composition comprises the following components in parts by weight: 0.01-0.3 parts of honokiol; 0.01-0.3 parts of totarol; 0.1-2 parts of nano sulfur. The mite removing composition provided by the invention is compounded by using various plant extracts, contains natural plant components, is mild and non-irritant, has the synergistic effect of various active components, can achieve a good sterilization and mite removing effect under the condition of a low usage amount, and can reduce the usage amount of a preservative in cosmetics and reduce irritation to skin.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a mite removing composition and a preparation method and application thereof.
Background
Human Demodex mites are conditionally pathogenic small parasitic mites, namely common Demodex folliculorum and Demodex sebaceus, are mainly parasitic in hair follicles and sebaceous glands, have weak resistance to high temperature, dry and alkaline environments, and can cause various common skin diseases under certain conditions, and possible mechanisms of causing skin damage comprise mechanical blockage of the hair follicles, expansion of the hair follicles and hyperkeratosis; resistance is reduced, and bacterial and fungal infection is easy to cause; the chitin exoskeleton of mites contributes to the formation of granulomas; the excretion of demodex mites can activate the immune system to cause delayed hypersensitivity and the like, which seriously affects the health and beauty of people.
At present, most of products for mildly removing mites with plant preparations on the market are added with plant extracts with the effects of sterilizing and removing mites, for example, patent CN111789786A discloses a mite removing plant composition, the mite removing effect is realized through the synergistic effect among rosewood seed extracts, pricklyash peel extracts, bitter ginseng root extracts, radix stemonae petiolatae extracts and phellodendron amurense bark extracts, generally, the active ingredients of the preparations playing the main role are not high, and the mite removing effect can be really realized by large addition amount, and the extracts related to the herbal medicines also contain more other complex ingredients and extraction solvents, and the large amount of the extracts added into the products have other potential risks and can also influence the stability, appearance, smell and the like of the system. In addition, some manufacturers choose to add or compound a certain amount of chemical mite removing agents in the formula to achieve a good mite removing effect, but the chemical mite removing agents often have certain irritation to the skin, and some chemical mite removing agents also have certain toxicity.
In general, there is currently a lack of technical applications related to natural actives that are able to achieve highly effective mite removal, and that are mild and non-irritating.
Disclosure of Invention
The invention aims to overcome the defects that the prior art has poor mite killing effect or has certain irritation to skin, and provides a mite killing composition. The mite removing composition provided by the invention is compounded by using various plant extracts, contains natural plant components, is mild and non-irritant, has the synergistic effect of various active components, can achieve a good sterilization and mite removing effect under the condition of a low usage amount, and can reduce the usage amount of a preservative in cosmetics and reduce irritation to skin.
The invention also aims to provide a preparation method of the mite removing composition.
The invention also aims to provide application of the mite removing composition in preparation of cosmetics.
In order to achieve the purpose, the invention adopts the following technical scheme:
the mite removing composition comprises the following components in parts by weight:
0.01-0.3 parts of magnolol;
0.01-0.3 parts of totarol;
0.1-2 parts of nano sulfur.
Honokiol, commonly found in magnolia officinalis of magnolia of magnoliaceae, is 3, 5-di-2-propenyl-1, 1-biphenyl-2, 4-diol, is a fine powder of brown to white, is dissolved in ethanol, propylene glycol, hexanediol or other alkaline media, has a broad-spectrum antibacterial effect, has strong antibacterial activity against gram-positive bacteria and gram-negative bacteria, is stable in antibacterial property, is not easily damaged by heat, acid and alkali, and has the strongest inhibitory effect on staphylococcus aureus; the inventor finds that the mite killing composition also has better mite killing and synergistic mite killing effects.
The totarol is commonly found in the podocarpus macrophyllus, is rich in aromatic diterpene, can inhibit the peroxidation of grease, is a high-efficiency antibacterial agent, has good antibacterial effect on gram-positive bacteria including streptococcus, bacillus subtilis, staphylococcus aureus, propionibacterium acnes and the like, and has no irritation and anaphylactic reaction to human skin. The inventor finds that the mite killing composition also has certain mite killing and synergistic mite killing effects.
The nanometer sulfur has effects of killing sarcoptic mite, bacteria and fungi, removing oil and fat, softening epidermis, and dissolving cutin, and its action mechanism is that sulfur contacts skin and tissue secretion to generate hydrogen sulfide and pentasulfuric acid.
Repeated experiments show that the magnolol, totarol and nano sulfur are specifically compounded, so that the composition has a good synergistic effect on mite removal, the composition obtained by compounding the magnolol, totarol and nano sulfur contains natural plant components, is mild and non-irritant, and multiple active components have synergistic effect, so that a good sterilizing and mite removing effect can be achieved under the condition of low using amount, meanwhile, the using amount of a preservative in cosmetics can be reduced, and the irritation to the skin is reduced. The reason is probably that the nano sulfur can soften, remove redundant cutin of the skin and dredge pores, and the totarol can regulate grease secretion and has synergistic effect with honokiol to achieve the effects of inhibiting bacteria and removing mites.
Preferably, the mite removing composition comprises the following components in parts by weight:
0.015-0.15 parts of honokiol;
0.015-0.15 part of totarol;
0.3-1.0 part of nano sulfur.
Further preferably, the mite removing composition comprises the following components in parts by weight:
0.03 part of honokiol;
0.08 part of totarol;
0.5 part of nano sulfur.
Preferably, the honokiol and the totarol are commercially available raw materials, and the purity is more than 98%.
Preferably, the nano sulfur is nano biological sulfur.
Preferably, the nano biological sulfur is coated in a nano carrier.
Preferably, the nano-carrier is one or a combination of lipoic acid, phospholipid and caprylic/capric triglyceride.
The nanometer sulfur can be suspended in the colloidal solution, has better diffusion and higher skin activity, and has no irritation to the skin. The interaction effect of the nano sulfur and the skin depends on the particle size, and the larger the effective area of the interaction between the sulfur and the skin, the greater the effect.
Preferably, the particle size of the nano sulfur is 1-100 μm.
The preparation method of the mite removing composition comprises the following steps: mixing the honokiol, the totarol, the nano sulfur and water to obtain the mite removing composition.
Preferably, the temperature of the mixing is 40-45 ℃.
Preferably, the mixing time is 30-40 min.
The mite removing composition (or a diluent thereof (the mass fraction of the mite removing composition is 0.2-3.0 wt%)) can be directly sprayed on the skin.
The mite-killing composition can also be added to mite-killing products (such as cosmetics) as an effective component.
The application of the mite removing composition in preparing mite removing products is also within the protection scope of the invention.
Preferably, in the mite removing product, the addition amount of the mite removing composition is 0.2-3.0 wt%.
Compared with the prior art, the invention has the following beneficial effects:
the mite removing composition provided by the invention is compounded by using various plant extracts, contains natural plant components, is mild and non-irritating, can play a good role in sterilizing and removing mites under the condition of low usage amount through the synergistic effect of magnolol, totarol and nano sulfur, and can also reduce the usage amount of preservatives in cosmetics and reduce irritation to skin.
Detailed Description
The invention is further illustrated by the following examples. These examples are intended to illustrate the invention and are not intended to limit the scope of the invention. Experimental procedures without specific conditions noted in the examples below, generally according to conditions conventional in the art or as suggested by the manufacturer; the raw materials, reagents and the like used are, unless otherwise specified, those commercially available from the conventional markets and the like. Any insubstantial changes and substitutions made by those skilled in the art based on the present invention are intended to be covered by the claims.
The raw materials selected in the examples and comparative examples of the present invention are as follows:
honokiol: HPH98, 98% pure, available from Hunan and Guang Biotech Co., Ltd;
peach pitopool: wkq-05832, the purity is more than or equal to 98 percent, and the product is purchased from Szechwan Vickqi Biotechnology Co., Ltd;
nano sulfur: nanoactive sulfurur, available from Philips biomedicine.
Examples 1 to 5 and comparative examples 1 to 3
In this embodiment, a series of mite-killing compositions are provided, and magnolol, totarol and nano sulfur are mixed according to the formula in table 1 to obtain the mite-killing compositions.
The mite killing composition is diluted into a diluent with the mass fraction of 2.0 wt% to obtain the mite killing composition diluent of the examples 1-5 and the comparative examples 1-3.
TABLE 1 formulation of mite-killing composition for each example and comparative example (parts by weight, total weight 100 parts)
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Honokiol | 0.01 | 0.015 | 0.03 | 0.15 | 0.3 | / | 0.03 | 0.03 |
| Peach tocol | 0.01 | 0.015 | 0.08 | 0.15 | 0.3 | 0.08 | / | 0.08 |
| Nano sulfur | 0.1 | 0.3 | 0.5 | 1.0 | 2.0 | 0.5 | 0.5 | / |
。
Comparative example 4
The comparative example is a commercial kernel and wormwood mite control spray.
Performance testing
The mite-killing compositions provided in the examples and comparative examples were tested according to the following test methods.
1. The mite removing effect is as follows: according to NY/T1151.2-2006 pesticide indoor pesticide effect test method for pesticide registration hygiene and evaluation part 2: the mite killing and expelling agent performs a mite killing effect test.
In which the test groups were sprayed with the diluted mite removing compositions prepared in the examples and comparative examples, and the blank control group was not treated at all.
The mite killing rate is death test insect number/test insect number multiplied by 100%
The test results are shown in table 2:
table 2 results of mite removal test for each of the exemplary and comparative examples dilutions of each of the mite removal compositions
As can be seen from Table 2, the mite killing effect of the mite killing composition provided by the embodiments of the invention shows better results, and the mite killing rate can reach more than 95% by using the components in a lower dosage in a compounding way. As can be seen from example 3 and comparative examples 1-3, the composition has a significantly reduced acaricidal effect in the absence of one of honokiol, totarol or nano-sulfur. Compared with the commercial mite removing product, the mite removing agent has remarkable effect.
It will be appreciated by those of ordinary skill in the art that the examples provided herein are intended to assist the reader in understanding the principles of the invention and are to be construed as being without limitation to such specifically recited examples and embodiments. Those skilled in the art can make various other specific changes and combinations based on the teachings of the present invention without departing from the spirit of the invention, and these changes and combinations are within the scope of the invention.
Claims (10)
1. The mite removing composition is characterized by comprising the following components in parts by weight:
0.01-0.3 parts of honokiol;
0.01-0.3 parts of totarol;
0.1-2 parts of nano sulfur.
2. The acarus killing composition as claimed in claim 1, which comprises the following components in parts by weight:
0.015-0.15 parts of honokiol;
0.015-0.15 part of totarol;
0.3-1.0 part of nano sulfur.
3. The acarus killing composition as claimed in claim 1, which comprises the following components in parts by weight:
0.03 part of honokiol;
0.08 part of totarol;
0.5 part of nano sulfur.
4. The acarus killing composition as claimed in claim 1, wherein the nano sulfur is nano biological sulfur.
5. The acarus killing composition as claimed in claim 4, wherein the particle size of the nano biological sulfur is 1-100 μm.
6. A process for preparing an acarus killing composition as claimed in any one of claims 1 to 5, which comprises the steps of: mixing the honokiol, the totarol and the nano sulfur to obtain the mite killing composition.
7. The method of preparing an acarus killing composition as claimed in claim 6, wherein the temperature of mixing is 40-45 ℃.
8. The method for preparing an acarus killing composition according to claim 6, wherein the mixing time is 30-40 min.
9. Use of the mite-killing composition of any one of claims 1 to 5 in the preparation of a mite-killing product.
10. The mite removing product for the application of claim 9, wherein the mite removing composition is added to the mite removing product in an amount of 0.2-3.0 wt%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011639501.6A CN112618395B (en) | 2020-12-31 | 2020-12-31 | Mite-killing composition and preparation method and application thereof |
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| CN112618395A true CN112618395A (en) | 2021-04-09 |
| CN112618395B CN112618395B (en) | 2023-08-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113208949A (en) * | 2021-05-11 | 2021-08-06 | 煜宠宠物(湖北)有限公司 | Shower gel for treating fungal dermatosis of pets and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040156873A1 (en) * | 2003-02-10 | 2004-08-12 | Gupta Shyam K. | Topically Bioavailable Acne and Rosacea Treatment Compositions |
| WO2011038797A1 (en) * | 2009-10-02 | 2011-04-07 | Beiersdorf Ag | Use of magnolol or honokiol as antibacterial, antimycotic, antiparasitic, or antiviral active ingredients |
| CN105055380A (en) * | 2015-09-15 | 2015-11-18 | 中国药科大学 | Application of totarol to preparation of drug for preventing and treating ischemic cerebral apoplexy |
| CN106581687A (en) * | 2016-12-22 | 2017-04-26 | 吉林大学 | Totarol antibacterial nano hydrogel with whey protein as matrix and preparation method thereof |
| CN107523453A (en) * | 2017-08-25 | 2017-12-29 | 张悦健 | Except mite liquid soap and preparation method thereof |
| CN111346023A (en) * | 2020-04-15 | 2020-06-30 | 广州立白企业集团有限公司 | Plant bacteriostatic composition, mouthwash containing composition and preparation method of mouthwash |
| CN111631993A (en) * | 2020-06-08 | 2020-09-08 | 广东芭薇生物科技股份有限公司 | Composition containing sophora flavescens and magnolia officinalis extracts and cosmetic using composition |
-
2020
- 2020-12-31 CN CN202011639501.6A patent/CN112618395B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040156873A1 (en) * | 2003-02-10 | 2004-08-12 | Gupta Shyam K. | Topically Bioavailable Acne and Rosacea Treatment Compositions |
| WO2011038797A1 (en) * | 2009-10-02 | 2011-04-07 | Beiersdorf Ag | Use of magnolol or honokiol as antibacterial, antimycotic, antiparasitic, or antiviral active ingredients |
| CN105055380A (en) * | 2015-09-15 | 2015-11-18 | 中国药科大学 | Application of totarol to preparation of drug for preventing and treating ischemic cerebral apoplexy |
| CN106581687A (en) * | 2016-12-22 | 2017-04-26 | 吉林大学 | Totarol antibacterial nano hydrogel with whey protein as matrix and preparation method thereof |
| CN107523453A (en) * | 2017-08-25 | 2017-12-29 | 张悦健 | Except mite liquid soap and preparation method thereof |
| CN111346023A (en) * | 2020-04-15 | 2020-06-30 | 广州立白企业集团有限公司 | Plant bacteriostatic composition, mouthwash containing composition and preparation method of mouthwash |
| CN111631993A (en) * | 2020-06-08 | 2020-09-08 | 广东芭薇生物科技股份有限公司 | Composition containing sophora flavescens and magnolia officinalis extracts and cosmetic using composition |
Non-Patent Citations (2)
| Title |
|---|
| 氧哥趣健康: "简单洗个澡，肌肤白嫩、更明艳动人" * |
| 谈娟，等: "纳米级硫磺的微观分析及对性能的影响", pages 99 - 106 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113208949A (en) * | 2021-05-11 | 2021-08-06 | 煜宠宠物(湖北)有限公司 | Shower gel for treating fungal dermatosis of pets and preparation method thereof |
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| CN112618395B (en) | 2023-08-29 |
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