CN114288224B - Mite-removing and disinfecting composition and preparation method and application thereof - Google Patents
Mite-removing and disinfecting composition and preparation method and application thereof Download PDFInfo
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides an acarid-removing and disinfecting composition, a preparation method and application thereof. The mite-removing and disinfecting composition comprises the following components in parts by weight: 20-50 parts of acer truncatum leaf extract, 20-40 parts of melaleuca alternifolia essential oil microcapsule, 10-25 parts of melaleuca alternifolia branch and leaf extract and 5-25 parts of salt. The mite-killing and disinfecting composition provided by the invention is compounded by using plant extracts, is mild and does not irritate, and a plurality of active ingredients act synergistically, so that good sterilizing and mite-killing effects can be obtained under the condition of low usage amount. Meanwhile, the composition has stable performance and low cost, is suitable for sterilization and disinfection of places and industries such as schools, hospitals, public transportation means and the like, and is also suitable for being added into daily chemicals for daily mite removal and sterilization.
Description
Technical Field
The invention relates to the technical field of daily chemical products, in particular to an mite-removing and disinfecting composition, a preparation method and application thereof.
Background
Mites are a miniature pest which has great harm to human health, are very various, have soft and very small body shapes, can be just seen by naked eyes, have the size of about 0.5mm, and have the size of 0.1mm. It is widely used in every corner of our daily life, such as carpets, sofas, mattresses, pillows, summer sleeping mats, etc., and can be parasitic in the pilo-sebaceous glands of human skin to absorb nutrient substances and sebum secretion in cells, thereby damaging human skin; and the excrement and the remains thereof are strong allergic sources, and can cause skin itch, allergic rhinitis, respiratory tract infection, urticaria, asthma and other symptoms.
At present, most people adopt a physical method, such as a method of using a mite removing instrument, sun exposure, frequent washing and the like, various chemical mite removing products such as mite removing bags, mite removing sprays and the like are different, most of the chemical mite removing products claim that the plants remove mites and drive mites, but most of the chemical mite removing products are plant extracts with the functions of sterilizing and removing mites and the like, usually the active ingredients of the agents playing a main role are not high, a large adding amount is often required to really realize the mite removing effect, the extracts related to the Chinese herbal medicines also contain more other complex ingredients and extracting solvents, other potential risks are caused when the extracts are added into the products in a large amount, and the stability, the appearance, the smell and the like of the system can be influenced. In addition, certain chemical mite-killing agents are added or compounded in the formula by a merchant to achieve a better mite-killing effect, but certain chemical mite-killing agents also contain certain toxicity.
Acer truncatum (Acer Truncatum Bunge), also known as Acer truncatum, is a tree of Aceraceae family, and is named as ancient "gold ingot" because of its samara shape. Belongs to the special tree species in China. The plant is rich in various secondary metabolites and bioactive substances, has various benefits such as medicinal use, oil, tannin, chemical industry, greening, ornamental effect, water and soil conservation and the like, and has high development and utilization values. The acer truncatum leaf extract contains rich flavone and chlorogenic acid, has remarkable degerming effect, can resist alkaline environment, has strong oxidation resistance, and has good inhibitory activity on escherichia coli, staphylococcus aureus, salmonella, hemolytic streptococcus, bacillus subtilis and pseudomonas aeruginosa. Low cost, easy availability and high safety.
The melaleuca alternifolia (Melaleuca alternifolia Cheel) is also called Australian tea tree, belongs to melaleuca plants of Myrtaceae, is native to the regions of the south of Australia, such as 23.5-degree coastal region and the north of the northern territory, and is known as Australian national treasures. In the 90 th century, the white-layer tree seeds of the leaves of the plant are successfully introduced in Guangdong, guangxi, hainan, fujian, yunnan and the like of China, a certain planting scale is formed, and in recent years, a large amount of plants are planted in the south of China. According to the clinical test of modern science and medicine, the essential oil of melaleuca alternifolia (Australian tea tree) contains terpineol, terpinene, eucalyptol, various chemical components such as cymene, limonene, terpinene and the like, is a powerful broad-spectrum bactericidal substance, has stronger activity inhibition capability and the effects of resisting bacteria, sterilizing, inhibiting bacteria, activating cells by killing viruses and the like for 57 of 58 bacteria, fungi and viruses in nature, has the sterilization effect which is 11-13 times of that of the lithocarbonic acid, and is listed in the purchase directory of the Food and Drug Administration (FDA); in 2001, the European pharmacopoeia is also included. The melaleuca alternifolia branches and leaves contain rich flavone, betulinic acid, gallic acid, beta-sitosterol, protocatechuic acid and the like, and the extract has strong antioxidant activity and remarkable degerming effect, and has good inhibitory activity on escherichia coli, staphylococcus aureus, salmonella, streptococci, and the like.
Disclosure of Invention
The invention aims to overcome the defects of poor mite removal effect or certain skin irritation in the prior art and provide a mite removal and disinfection composition. The mite-killing and disinfecting composition provided by the invention is compounded by using the plant extract, contains natural plant components, is mild and non-irritating, has the synergistic effect of various active components, can achieve good antibacterial and mite-killing effects in air, bedding and places suitable for mite growth under the condition of low usage amount, and can also reduce the usage amount of preservatives in daily chemical products by using the antioxidant activity of the plant extract.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
the mite-removing and disinfecting composition comprises the following components in parts by weight: 20-50 parts of acer truncatum leaf extract, 20-40 parts of melaleuca alternifolia essential oil microcapsule, 10-25 parts of melaleuca alternifolia branch and leaf extract and 5-25 parts of salt (NaCl).
Preferably, the mite-killing composition comprises the following components in parts by weight: 25-40 parts of acer truncatum leaf extract, 30-40 parts of melaleuca alternifolia essential oil microcapsule, 15-20 parts of melaleuca alternifolia branch and leaf extract and 10-20 parts of salt.
Further preferably, the mite-killing composition comprises the following components in parts by weight: 36 parts of acer truncatum leaf extract, 31 parts of melaleuca alternifolia essential oil microcapsule, 19 parts of melaleuca alternifolia branch and leaf extract and 14 parts of salt.
Further, the acer truncatum leaf extract is prepared by taking acer truncatum leaves as raw materials, cleaning, airing, crushing, leaching with 7-10 times of ethanol with the weight of V/V of 50-70%, under the assistance of ultrasonic waves at the temperature of 60-80 ℃ for 1-2 hours, filtering to obtain leaching liquor A, leaching residues with 4-5 times of ethanol with the weight of V/V of 50-70% under the assistance of ultrasonic waves at the temperature of 60-80 ℃ for 1-2 hours, filtering to obtain leaching liquor B, and merging leaching liquor A, B; recovering ethanol by vacuum concentration, adsorbing by NKA-9 macroporous resin, eluting with 60-70% ethanol after water washing and decolorizing, concentrating the eluent by double-effect membrane, and spray drying to obtain Acer Truncatum Bunge leaf extract with total flavone content of 26-28% and chlorogenic acid content of 17-20%.
Further, the melaleuca alternifolia essential oil microcapsule is prepared by dissolving modified starch, or beta-cyclodextrin, or sodium caseinate and acacia in hot water to prepare a saturated solution, dissolving melaleuca alternifolia essential oil in ethanol, adding the melaleuca alternifolia essential oil ethanol solution into an aqueous solution of the modified starch, or the beta-cyclodextrin, or sodium caseinate and acacia under the stirring condition, stirring for 1-2 hours, homogenizing for 2 times under the high pressure of 25-35 MPa, and spray drying to obtain melaleuca alternifolia essential oil microcapsule powder with the coating rate of 58-60%.
Further, the melaleuca alternifolia branch and leaf extract is prepared by taking melaleuca alternifolia branch and leaf residues after extracting melaleuca alternifolia essential oil by water vapor as a raw material, airing the melaleuca alternifolia branch and leaf residues, crushing the melaleuca alternifolia, leaching the melaleuca alternifolia branch and leaf residues for 1 to 2 hours at the temperature of 60 to 80 ℃ with the aid of ultrasonic waves by using 7 to 10 times of ethanol with the weight of V/V of 50 to 70%, filtering the melaleuca alternifolia branch and leaf residues, leaching the residues for 1 to 2 hours at the temperature of 60 to 80 ℃ with the aid of ultrasonic waves by using 4 to 5 times of ethanol with the weight of V/V of 50 to 70%, filtering the residues to obtain leaching liquor B, and combining leaching liquor A, B; recovering ethanol by concentrating under reduced pressure, adsorbing with AB-8 macroporous resin, washing with water for decolorizing, eluting with 60-70% ethanol, concentrating the eluate with double-effect membrane, and spray drying to obtain extract of Melaleuca alternifolia branch and leaf with total flavone content of 32-26%.
Further, the preparation method of the mite-killing and disinfecting composition comprises the following steps: and taking the acer truncatum leaf extract, the melaleuca alternifolia essential oil microcapsule, the melaleuca alternifolia branch and leaf extract and salt according to a proportion, and uniformly mixing to obtain the mite-removing and sterilizing composition.
Further, the mite-removing and disinfecting composition can be applied to the preparation of daily chemical products, wherein the daily chemical products comprise any one of soaps, water agents, emulsions, creams, gels, sprays, washing and protecting products, facial mask daily products or washing and protecting daily products, and the adding amount of the mite-removing and disinfecting composition in the daily chemical products is 0.6-15.0wt%.
Further, the mite-killing and disinfecting composition is applied to preparing mite-killing and disinfecting products, and the adding amount of the mite-killing and disinfecting composition in the mite-killing and disinfecting products is 0.6-15.0wt%.
The invention has the beneficial effects that:
the mite-killing and disinfecting composition provided by the invention is compounded by using the plant extract, contains natural plant components, is mild and non-irritating, has unexpected mite-killing and disinfecting effects due to the synergistic effect of various active components, and can achieve good mite-killing and disinfecting effects under the condition of low usage amount. Meanwhile, the composition has stable performance and low cost; is suitable for sterilizing public places and industries such as schools, hospitals, aviation and the like, and removing mites and sterilizing in a household environment.
Detailed Description
The invention is described in further detail in the following description of specific embodiments, it being understood that these embodiments are provided only for illustrating the invention and not for limiting the scope of the invention, and that various equivalent modifications of the invention will fall within the claims appended hereto, after reading the invention.
The invention is further elucidated below in connection with the specific embodiments.
The acer truncatum leaf extract is extracted by the following method:
cleaning and airing Acer truncatum leaves, crushing, leaching with 7-10 times of ethanol with the weight of V/V of 50-70% for 1-2 hours at the temperature of 60-80 ℃ under the assistance of ultrasonic waves, filtering to obtain leaching liquor A, leaching residues with 4-5 times of ethanol with the weight of V/V of 50-70% for 1-2 hours at the temperature of 60-80 ℃ under the assistance of ultrasonic waves, filtering to obtain leaching liquor B, and combining leaching liquor A, B; recovering ethanol by vacuum concentration, adsorbing by NKA-9 macroporous resin, eluting with 60-70% ethanol after water washing and decolorizing, concentrating the eluent by double-effect membrane, and spray drying to obtain Acer Truncatum Bunge leaf extract with total flavone content of 26-28% and chlorogenic acid content of 17-20%.
The melaleuca alternifolia essential oil microcapsule is prepared by the following steps:
dissolving modified starch or beta-cyclodextrin or sodium caseinate and acacia in hot water to prepare saturated solution, dissolving melaleuca alternifolia essential oil in ethanol, adding melaleuca alternifolia essential oil ethanol solution into aqueous solution of modified starch or beta-cyclodextrin or sodium caseinate and acacia under stirring, stirring for 1-2 hours, homogenizing under high pressure for 2 times under 25-35 MPa, and spray drying to obtain melaleuca alternifolia essential oil microcapsule powder with coating rate of 58-60%
The melaleuca alternifolia branch and leaf extract is extracted by the following method:
airing the residue of the melaleuca alternifolia branches and leaves after extracting melaleuca alternifolia essential oil by water vapor, crushing, leaching with 7-10 times of ethanol with the weight of V/V of 50-70% for 1-2 hours at the temperature of 60-80 ℃ under the assistance of ultrasonic waves, filtering to obtain leaching liquor A, leaching the residue with 4-5 times of ethanol with the weight of V/V of 50-70% for 1-2 hours at the temperature of 60-80 ℃ under the assistance of ultrasonic waves, filtering to obtain leaching liquor B, and merging leaching liquor A, B; recovering ethanol by concentrating under reduced pressure, adsorbing by AB-8 macroporous resin, eluting with 60-70% ethanol after water washing and decolorizing, concentrating the eluate by double-effect membrane, and spray drying to obtain melaleuca alternifolia branch and leaf extract with total flavone content of 32-26%.
Table 1 composition of examples and comparative examples (parts by weight)
In a specific embodiment, the Acer truncatum leaf extract, melaleuca alternifolia essential oil microcapsule powder and melaleuca alternifolia branch and leaf extract obtained in the above manner are adopted. Uniformly mixing the acer truncatum leaf extract, the melaleuca alternifolia essential oil microcapsule, the melaleuca alternifolia branch and leaf extract and the salt according to parts by weight to obtain the mite-removing and disinfecting composition.
The present invention provides a series of the above mite-removing and disinfecting compositions, and the compositions of examples 1 to 4 and comparative examples 1 to 5 are shown in the formulations of Table 1.
Next, the anti-bacterial properties and anti-mite effects of the mite-killing and disinfecting compositions of the present invention were tested.
(1) Antibacterial property detection
The experimental method is implemented according to GB/T15979-2012 hygienic Standard for Disposable hygienic products, and the microorganism strains are as follows: coli (ATCC 8739), candida albicans (ATCC 10231) and staphylococcus aureus (ATCC 6538) under the test conditions of the test liquid of the dilution liquid of the sample 1:100 according to the annex C4, and the test results of the examples 1-4 and the comparative examples 1-5 are shown in the table 2.
(2) Mite removal effect test
According to NY/T1151.2-2006, method for testing indoor efficacy of pesticides for pesticide registration sanitary purposes, evaluation part 2: mite killing and dispelling agent mite killing effect test is carried out. Wherein, the test group is sprayed with the mite-removing and disinfecting composition diluent prepared in each example and comparative example, and the blank control group is not treated at all. The test results are shown in Table 2.
TABLE 2 antibacterial and overfill rates (%)
| Test case | Coli bacterium | Candida albicans | Staphylococcus aureus | Mite killing rate |
| Example 1 | 99.99 | 99.99 | 99.99 | 100 |
| Example 2 | 99.72 | 99.86 | 99.55 | 99.5 |
| Example 3 | 99.43 | 99.75 | 99.77 | 100 |
| Example 4 | 99.78 | 99.85 | 99.58 | 99.9 |
| Comparative example 1 | 69.68 | 72.32 | 68.76 | 86.4 |
| Comparative example 2 | 77.27 | 74.56 | 73.59 | 87.7 |
| Comparative example 3 | 82.27 | 79.56 | 77.12 | 89.3 |
| Comparative example 4 | 83.31 | 79.78 | 81.49 | 90.6 |
| Comparative example 5 | 85.42 | 81.15 | 78.86 | 88.97 |
| Blank control | 3.5 |
As can be seen from Table 2, the aqueous solutions of the mite-killing and disinfecting compositions provided in examples 1 to 4 have a bacteriostatic rate of more than 99.5% against Staphylococcus aureus, escherichia coli and Candida albicans, which indicates that the compositions provided by the present invention have unexpected mite-killing and disinfecting effects.
As can be seen from the comparison of examples 1-4 and comparative examples 1-4, the mite-removing and disinfecting composition provided by the invention has better inhibiting effect on staphylococcus aureus, escherichia coli and candida albicans through the synergistic effect of the acer truncatum leaf extract, the melaleuca alternifolia essential oil microcapsule and the melaleuca alternifolia branch and leaf extract.
In general, the lack of any one or the improper proportion of the components can greatly reduce the bacteriostatic effect.
As can be seen from Table 2, the mite-killing and disinfecting compositions provided in examples 1 to 4 of the present invention all exhibited good results, and the mite-killing rate of each example was 99.5% or more.
As can be seen from the comparison of examples 1 to 4 and comparative examples 1 to 4, the mite-removing and disinfecting composition provided by the invention has excellent mite-killing effect through the synergistic effect of the acer truncatum leaf extract, the melaleuca alternifolia essential oil microcapsule and the melaleuca alternifolia branch and leaf extract.
In general, the absence of either or both of the above components in the improper proportions results in a significant reduction in the killing effect against mites.
The above examples are only for illustrating the detailed method of the present invention, and the present invention is not limited to the above detailed method, i.e., it does not mean that the present invention must be implemented depending on the above detailed method. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.
Claims (5)
1. The mite-killing composition is characterized by comprising the following components in parts by weight: 20-50 parts of acer truncatum leaf extract, 20-40 parts of melaleuca alternifolia essential oil microcapsule, 10-25 parts of melaleuca alternifolia branch and leaf extract and 5-25 parts of salt; the total flavone content of the acer truncatum leaves extract is 26-28%, and the chlorogenic acid content is 17-20%; the total flavone content of the melaleuca alternifolia branch and leaf extract is 32-26%;
step 1, preparing an acer truncatum leaf extract, which comprises the following steps: cleaning and airing Acer truncatum leaves serving as raw materials, crushing, leaching with 7-10 times of ethanol with the weight of V/V of 50-70% for 1-2 hours at the temperature of 60-80 ℃ under the assistance of ultrasonic waves, filtering to obtain leaching liquor A, leaching residues with 4-5 times of ethanol with the weight of V/V of 50-70% for 1-2 hours at the temperature of 60-80 ℃ under the assistance of ultrasonic waves, filtering to obtain leaching liquor B, and combining leaching liquor A, B; concentrating under reduced pressure to recover ethanol, adsorbing by NKA-9 macroporous resin, washing with water to decolorize, eluting with 60-70% ethanol, concentrating the eluate by double-effect membrane, and spray drying to obtain the Acer Truncatum Bunge leaf extract;
step 2, preparing melaleuca alternifolia essential oil microcapsules, which comprise the following steps: dissolving modified starch or beta-cyclodextrin or sodium caseinate and Arabic gum in hot water to prepare saturated solution, dissolving melaleuca alternifolia essential oil in ethanol, adding melaleuca alternifolia essential oil ethanol solution into aqueous solution of modified starch or beta-cyclodextrin or sodium caseinate and Arabic gum, stirring for 1-2 hours, homogenizing for 2 times under high pressure of 25-35 MPa, and spray drying to obtain melaleuca alternifolia essential oil microcapsule powder with a coating rate of 58-60%;
step 3, preparing a melaleuca alternifolia branch and leaf extract, which comprises the following steps: extracting melaleuca alternifolia branch and leaf residues after extracting melaleuca alternifolia essential oil by using water vapor as a raw material, airing the melaleuca alternifolia branch and leaf residues, crushing the materials, leaching the crushed materials for 1 to 2 hours at the temperature of 60 to 80 ℃ with the aid of ultrasonic waves by using 7 to 10 times of ethanol with the weight of V/V of 50 to 70%, filtering the leached liquid A, leaching the residues for 1 to 2 hours with the aid of ultrasonic waves by using 4 to 5 times of ethanol with the weight of V/V of 50 to 70% at the temperature of 60 to 80 ℃, filtering the leached liquid B, and merging leaching liquid A, B; recovering ethanol by concentrating under reduced pressure, adsorbing with AB-8 macroporous resin, eluting with 60-70% ethanol after water washing and decolorizing, concentrating the eluate with double-effect membrane, and spray drying to obtain the Melaleuca alternifolia branch and leaf extract;
and 4, taking the Acer truncatum Bunge leaf extract, the melaleuca alternifolia essential oil microcapsule, the melaleuca alternifolia branch and leaf extract and salt according to a proportion, and uniformly mixing to obtain the mite-removing composition.
2. The mite-killing composition according to claim 1, which comprises the following components in parts by weight: 25-40 parts of acer truncatum leaf extract, 30-40 parts of melaleuca alternifolia essential oil microcapsule, 15-20 parts of melaleuca alternifolia branch and leaf extract and 10-20 parts of salt.
3. The mite-killing composition according to claim 1, which comprises the following components in parts by weight: 36 parts of acer truncatum leaf extract, 31 parts of melaleuca alternifolia essential oil microcapsule, 19 parts of melaleuca alternifolia branch and leaf extract and 14 parts of salt.
4. Use of a mite-killing composition according to any one of claims 1-3 for the preparation of mite-killing products.
5. The use of the mite-killing composition according to claim 4 for preparing mite-killing products, wherein the mite-killing composition is added into the mite-killing products in an amount of 0.6-15.0 wt%.
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