CN106511471B - A kind of fig oral spray and preparation method thereof - Google Patents
A kind of fig oral spray and preparation method thereof Download PDFInfo
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- CN106511471B CN106511471B CN201611077374.9A CN201611077374A CN106511471B CN 106511471 B CN106511471 B CN 106511471B CN 201611077374 A CN201611077374 A CN 201611077374A CN 106511471 B CN106511471 B CN 106511471B
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- freeze
- extract
- fruit
- powder
- drying
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- 238000002474 experimental method Methods 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
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- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000021022 fresh fruits Nutrition 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000019990 fruit wine Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 description 1
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- 238000011645 inflammation animal model Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940127249 oral antibiotic Drugs 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000021264 seasoned food Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- 239000000811 xylitol Substances 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The invention discloses a kind of fig oral sprays and preparation method thereof.The fig oral spray is composed of the following components in terms of 1000mL: fig fruit extract freeze-drying powder 50g-150g, preservative 2g-6g, sorbefacient 40g-80g and surplus are deionized water；The sorbefacient is made of clinopodium grass saponin(e and cholate.The fig oral spray has the multiple efficacies such as antibacterial, anti-inflammatory, hemostasis, throat soothing, deodorization, easy to use, adapts to Modern human populations oral hygiene health demand.The preparation method of fig oral spray of the present invention, it is easy to operate, it is easily controllable, it is suitable for industrialized production, there is preferable promotional value.
Description
Technical field
The present invention relates to food and field of health care products, and in particular to a kind of fig oral spray and preparation method thereof.
Background technique
Fig (Ficus caricaLinn.) also known as mamoncillo, syconium, bright mouth fruit, Fructus Fici Beecheyanae, diverseleaf fig fruit, Gu Duzi,
Belong to Moraceae Ficus deciduous tree or shrub, be mainly grown on the torrid zone and temperate zone, belongs to subtropical zone defoliation small arbor, trunk is high, tree crown
Greatly, blade face is wide, two season of summer and autumn result.Fig fruit thin skin is seedless, and meat is soft, and flavor is sweet, containing various saccharides substance,
Flavone compound, organic acid, protein, microelement and vitamin C (Vc) isoreactivity ingredient, nutrition very abundant have
High nutritive value and medical value.Contain the substance with bacteriostatic activity: psoralen, benzaldehyde and Buddhist in common fig leaf juice
The substances such as hand mandarin orange lactones have fairly good Development volue and application prospect, however in real life production, it is most
Common fig leaf juice is all abandoned as waste, and the significant wastage of resource is caused, as can developing its new purposes, will improve nature money
The utility value in source.
It is measured according to Agricultural University Of Nanjing, protein 4.3%, 74.3% (wherein fruit of carbohydrate is contained in fig fruit
Sugar and glucose account for 15%-20%), and rich in microelements such as Ca, Mg, Zn, Na, Cu, B, contain 18 kinds of amino acid, wherein having
10 kinds are amino acid necessary to human body, 2 kinds of children's essential amino acids, aspartic acid content 0.475%-0.493%, Vc
Content be 2-3 times of citrus, 20 times of grape, also containing can largely adsorb various harmful substances in enteron aisle, purification enteron aisle,
Exclude diastase, hepatocuprein, esterase, the ester of the food fibers such as the pectin of carcinogenic chemical and anti-aging
The substances such as fat enzyme, protease.The exploitation of fig is concentrated mainly on fresh fruit storage and the shallower level such as edible, medicinal to its fruit
Value, the comprehensive hair research on utilization of fruit tree are less, therefore fig is put into the scope of anxious third generation fruit leaved for development, have compared with
Big researching value.
Existing fig class product has health protection tea, fruit wine, oral solution, fruit juice, lozenge, crisp chip, effervescent tablet, fruit in the market
Piece, biscuit, health-caring capsule, medicinal extract, jam, dried fruit, preserved fruit, can etc..Such as Chinese patent ZL201410203890.6 is disclosed
A kind of fig effervescent tablet, is grouped as by the group of following parts by weight: 10-30 parts of fig Thick many candies, vitamin C 5-
10 parts, 4-10 parts of filler, 10-30 parts of acid compound, 10-50 parts of alkali compounds, 0.5-5 parts of lubricant, adhesive 1-4
Part；The filler is selected from any one of starch, Icing Sugar, mannitol, dextrin, sucrose or any several combination；The acid
Property compound be selected from any one of citric acid, tartaric acid, fumaric acid, adipic acid, malic acid or any several combination；It is described
Alkali compounds is selected from sodium bicarbonate or/and sodium carbonate；The lubricant is selected from Macrogol 6000 or/and superfine silica gel powder；Institute
It states adhesive and is selected from any one of dehydrated alcohol, polyvinylpyrrolidone, hydroxypropyl cellulose or any several combination；It should
Fig effervescent tablet, fig polysaccharide purity is high, content is big, and nutritive value is high, can give full play to its health-care efficacy.At present also
It is not directed to oral spray field.Have effects that significantly to treat the throats such as laryngalgia, subdhing swelling and detoxicating in view of fig, can incite somebody to action
It is developed into such functional health product.And existing oral spray is such as: disclosing in Chinese patent ZL201010173269.1
A kind of oral spray, it mainly include water-soluble menthol, fresh breath substance, sweetener, xylitol, ethyl alcohol and go from
Sub- water, suitable for refreshing oneself or fresh breath when work, study.Sweetener side effect in the formula is more and will cause fertilizer
The health problems such as fat, hypertension, hyperglycemia, and the spray curative effect is general, and effect is single, and practicability is poor.Chinese patent
ZL201310209226.8 discloses a kind of horseradish oral spray, and the raw material of the oral spray has horseradish extracting solution, solubilising
Agent, sorbefacient, corrigent, simple syrup and ethanol solution surplus.Although the oral spray can help to eliminate oral cavity and throat
Inflamed sites inflammation inhibits bacterium in the growth at sphagitis erosion position, but horseradish is the one kind found in the world today
Special edible health plant is extremely precious seasoned food in the international market, expensive, the market demand is very big.By
Special in horseradish growth conditions, suitable growth plantation place is limited, and horseradish product is extremely rare, leads to horseradish oral spray
It is expensive, it is unable to popularity.Fig price is relatively low, and containing a large amount of in fig fruit and its leaves extract
Active constituent, including flavones, vitamin, microelement, amylase, lipase, protein, antifatigue anti senility asparagine
Acid, the antihypertensive bergamot lactones of anti-cancer and cancer-preventing, psoralen, benzaldehyde, polysaccharose substance etc., nutrition very abundant, tool
There is the effects of moistening lung to arrest cough, invigorating stomach and promoting bower movements, subdhing swelling and detoxicating, anti-inflammation detumescence, throat effect, and yield is high, cultivation management is easy,
Cheap, economic value is higher.Therefore, as can successfully exploitation fig oral spray class product will have a wide range of applications
Value.
Summary of the invention
For existing market situation, prepared using fig fruit extract freeze-drying powder as raw material the present invention provides a kind of
Fig oral spray.The fig oral spray has the multiple efficacies such as antibacterial, anti-inflammatory, hemostasis, throat soothing, deodorization, makes
With convenient, adaptation Modern human populations oral hygiene health demand.
The present invention also provides a kind of preparation methods of fig oral spray, and this method is easy to operate, easily controllable,
Suitable for industrialized production, there is preferable promotional value.
A kind of fig oral spray, composed of the following components in terms of 1000mL:
Fig fruit extract freeze-drying powder 50g-150g；
Preservative 2g-6g；
Sorbefacient 40g-80g；
Surplus is deionized water.
In above-mentioned formula, the preservative selects fig leaf extract, and main component is psoralen, can be used as
A kind of novel natural antisepsis fresh-keeping agent has good antibacterial anti-corrosion effect.
The sorbefacient is made of clinopodium grass saponin(e and cholate, wherein the quality of clinopodium grass saponin(e and cholate
Than being preferably 3:1.Clinopodium grass saponin(e and cholate have preferable synergistic effect between the two, and clinopodium grass saponin(e is as a kind of natural
Nonionic surface active agent, small colloidal particle can be formed in water, mentioned fig by forming micella effect
It takes flavones in object, polysaccharide and psoralen isoreactivity ingredient to be attached together, increases the permeability in iuntercellular water solubility channel,
Promote the absorption of water-soluble substances；And the cholate of low concentration with aquation and can extract intercellular lipid, mention to increase
Diffusion of the object in iuntercellular aqueous channels is taken, while cholate can be used as enzyme inhibitor, by influencing the activity of enzyme, changed more
The different mechanism such as peptide, protein conformation maintains the stabilization of drug, it is compounded with surfactant clinopodium grass saponin(e can be bright
The aobvious absorption for increasing fig oral spray effective component.The cholate selects commercial product, and glycocholic acid can be selected
One or both of sodium, glycochenodeoxycholate sodium, natrium taurocholicum, Irish moss (chondrux) sodium, NaTDC etc. with
On.
In order to reach better invention effect, it is preferable that the fig oral spray, in terms of 1000mL, by following
Group is grouped as:
Fig fruit extract freeze-drying powder 80g-150g；
Preservative 2g-5g；
Sorbefacient 40g-72g；
Surplus is deionized water.
It is (such as commercially available that existing fig fruit extract freeze-drying powder can be used in the fig fruit extract freeze-drying powder
Product) or using prior art preparation fig fruit extract freeze-drying powder, it is preferred to use following preparation method is prepared into
The fig fruit extract freeze-drying powder arrived:
The preparation method of the fig fruit extract freeze-drying powder, comprising the following steps:
Fig fruit is cleaned, obtains fig fruit powder (preferably crossing 60 meshes) after freeze-drying and crushing；It will be without flower
Fruits powder carries out Subcritical water chromotagraphy, extraction time 10min-40min by extracting solution of subcritical water；Subcritical hydraulic pressure
Power is 4MPa-7MPa, and temperature is 120 DEG C -180 DEG C, flow velocity 5L/h-10L/h；The concentrated drying of obtained extract is (preferably
Be concentrated and dried in 55 DEG C of vacuum distillations), freeze-drying, obtain containing the active nothing of the multicomponents such as fig polysaccharide, flavones and cellulose
Flowers and fruits fruit extract freeze-dried powder.
The fig leaf extract can be used existing fig leaf extract (such as commercial product) or using existing
The fig leaf extract for having technology to prepare, the fig leaf extract preferably select the fig leaf extract after drying
Such as fig leaf extract freeze-dried powder is further preferably prepared using following preparation method convenient for preparing spray
Fig leaf extract:
The preparation method of the fig leaf extract, comprising the following steps:
Common fig leaf juice is cleaned, obtains common fig leaf juice powder after freeze-drying and crushing；By common fig leaf juice powder with subcritical water
Subcritical water chromotagraphy, extraction time 20min are carried out for extracting solution；Subcritical water pressure is 5MPa, and temperature is 130 DEG C, flow velocity
For 8L/h；The concentrated drying of obtained extract (being preferably concentrated and dried in 55 DEG C of vacuum distillations) is lyophilized afterwards, obtains psoralea corylifolia
The higher fig leaf extract of cellulose content.
The clinopodium grass saponin(e can be used existing clinopodium grass saponin(e (such as commercial product) or use prior art system
Standby clinopodium grass saponin(e, the clinopodium grass saponin(e such as clinopodium grass saponin(e that the clinopodium grass saponin(e is preferably selected after drying are lyophilized
Powder, convenient for preparing spray, it is preferred to use the clinopodium grass saponin(e that following preparation method is prepared:
The preparation method of the clinopodium grass saponin(e, comprising the following steps:
Clinopodium grass is put into ultrasonic extraction 30min in the ethanol water of mass percentage concentration 80%, is obtained by filtration primary
Secondary filtrate is obtained by filtration in filtrate, filter residue ultrasonic extraction 30min in the ethanol water of mass percentage concentration 80%, merges
First-time filtrate and secondary filtrate obtain filtrate, and concentrating filter liquor (being preferably concentrated under reduced pressure at 30 DEG C), freeze-drying obtain higher degree
Clinopodium grass saponin extract.
The preparation method of the fig oral spray, comprising the following steps:
(1) clinopodium grass saponin(e is uniformly mixed the promotor that is absorbed with cholate；
(2) sorbefacient, preservative and appropriate amount of deionized water are uniformly mixed, mixed solution A is made；
(3) fig fruit extract freeze-drying powder is added into mixed solution A, is uniformly mixed, obtains mixed solution B；
(4) deionized water being added in mixed solution B and being settled to 1000mL, fig mouthspray is obtained after filter bacteria
Agent.
When preparing fig oral spray, the addition of active constituent fig fruit extract freeze-drying powder is prepared in advance
Containing sorbefacient, preservative mixed solution A in, relative to traditional mixed once method, can preferably play this
The effect of invention sorbefacient.
Fig oral spray obtained is filled into sprayer, fig oral spray product is obtained.
In conclusion fig oral spray of the present invention is one kind with a variety of natural activity components, fungistatic effect
Significantly, there is moistening lung to arrest cough, clearing away heat and moistening the bowels, the oral spray of removing toxicity for detumescence；The preparation of the above recipe ingredient can be according to reality
It needs to be adjusted.
Subcritical state is a kind of form relative to critical state and supercriticality.The pressure for controlling appropriateness, by water
100 DEG C are heated to 374 DEG C of high temperature below of upper critical temperature, water body stills remain in liquid condition, its polarity can be with temperature
Degree changes and changes, and this water is known as subcritical water.Water under subcritical water and normal temperature and pressure has bigger difference in nature, can
To adjust the polarity of subcritical water by control temperature and pressure, to achieve the purpose that selective extraction target component, use
Subcritical water proposes this novel extractive technique, can largely extract target component within a short period of time, technique tool
Effective percentage is high, the period is short, advantages of environment protection, is with a wide range of applications in terms of extracting active components of plants.
Clinopodium grass, also known as: calamint, ceylon leucas herb, Drilgrass, landing plum blossom, nine towers grass, red nine tower flower, wild Chinese mesona herb are
The herb of Labiatae (Labiatae) plant clinopodium grass ClinopodiumchinensisO.Kze..
Fig fruit and common fig leaf juice of the present invention preferably high-quality fresh fig fruit and high-quality common fig leaf juice.
The beneficial effects of the invention are that:
1, Ficus dual-purpose of drug and food resource, has no toxic side effect, and using the extract of common fig leaf juice as preservative,
Recycling for good anti-corrosion effect and common fig leaf juice waste can be played, the utilization of common fig leaf juice is improved
Rate.
2, compared with existing oral spray, antibiotic and ethyl alcohol are free of in oral spray of the present invention, will not be caused
The generation of bacterial drug resistance caused by antibiotic, and be equally applicable for alcohol or alcohol sensible crowd.With existing production
Condition is more less than the auxiliary material added in the present invention, can largely retain the unique fragrant of fig.
3, main component is fig fruit extract in inventive formulation, and extract effective component includes flavones, more
Sugar, amino acid and microelement etc. have excellent anti-aging, anticancer, anti-inflammation detumescence, throat and other effects.Common fig leaf juice
Extract highly concentrated flavone compound and Coumarins lactone nutrient, have good antiradical activities, have
Apparent antibacterial, anti-inflammatory and antivirus action, can be used as natural antibiotic antiseptic, are able to extend the storage of fig mouthspray
Time.
4, clinopodium grass belongs to Clinopodium in inventive formulation, and the chemical component of Clinopodium plant is extremely complex, containing Huang
The compounds such as ketone, saponins, organic acid, aromatic, triterpenes, steroid, wherein saponins compound is category plant
The main active of object, clinopodium grass saponin(e contain lipophilic triterpenes aglycon and the sugar chain compared with strongly hydrophilic, can be with nothing
Flowers and fruits extract combines and forms micelle, increases its solubility in a solvent, has the good absorbefacient effect of solubilising.Wind
Careless saponin(e is taken turns as a kind of natural nonionic surface active agent, small colloidal particle can be formed in water, pass through shape
It is acted at micella and flavones, polysaccharide and psoralen isoreactivity ingredient in Fructus Fici extract is attached together, increase cell
Between water-soluble channel permeability, promote the absorption of water-soluble substances；And the cholate of low concentration with aquation and can extract thin
Intercellular lipid leads to increase diffusion of the extract in iuntercellular aqueous channels, while cholate can be used as enzyme inhibitor
The activity for influencing enzyme is crossed, changes the stabilization that the different mechanism such as polypeptide, protein conformation maintains drug, by itself and surfactant
Clinopodium grass saponin(e compounds the absorption that can significantly increase fig oral spray effective component.
5, all components in inventive formulation are ingredient nontoxic, non-stimulated, that security performance is high, and most of ingredient is
Extracted form natural plant active constituent, can be safe to use.
6, about health fig product, at present on the market mainly using clearing as the tablet of healthcare function, lozenge, granule,
Based on the dosage forms such as tea bag, cream, mouthspray dosage form have it is easy to carry, take simple and fast advantage, while the product was both
It can play the role of protection throat, fresh breath, and there are health and beauty, prophylactic treatment oral cavity FAQs and other effects.It is special
Abscess of throat and prevention upper respiratory tract infection Shi Yongyu not treated.
Specific embodiment
Present invention is further described in detail with reference to embodiments.
Embodiment 1
The preparation method of fig oral spray, comprising the following steps:
1. the preparation of fig fruit extract freeze-drying powder:
(1.1) high-quality fresh fig fruit is selected, after rinsing well, is put into freeze dryer and is lyophilized；
(1.2) fig fruit after freeze-drying is shredded, is put into pulverizer and is ground into powder, crosses 60 meshes；
(1.3) dry fig fruit powder 120g is weighed, stainless steel is put into and extracts in kettle, is to extract with subcritical water
Liquid carries out Subcritical water chromotagraphy, extraction time 10min to the powder；Stainless steel extract kettle in subcritical water pressure be
4MPa, temperature are 120 DEG C, flow velocity 5L/h；Obtain extract；
(1.4) said extracted object is obtained in 55 DEG C of vacuum distillation concentrate dryings containing fig polysaccharide, flavones and fiber
The multicomponent activity extract of element etc., and place it in be lyophilized in freeze dryer and fig fruit extract freeze-drying powder is made.
2. the preparation of fig spray:
A. 45g clinopodium grass saponin(e (purchased from bright biological development corporation, Ltd., Baoji side) and 15g Irish moss (chondrux) are taken
Sodium (is purchased from Shanghai Yuan Ye Biotechnology Co., Ltd), is uniformly mixed the promotor 60g that is absorbed.
B. fig leaf extract freeze-dried powder (purchased from Xi'an Bioisystech Co., Ltd, Tianrui) 6g and appropriate deionization are taken
Water is mixed and stirred for uniformly in 250mL beaker, then it is uniformly mixed to prepare mixed solution A with 60g sorbefacient.
C. 70g fig fruit extract freeze-drying powder is added into mixed solution A to be uniformly mixed, obtains mixed solution B.
D. deionized water being added in mixed solution B and being settled to 1000mL, fig mouth is obtained after biofilter filters
Spray obtained is filled into sprayer by chamber spray, obtains fig oral spray product.
Embodiment 2
The preparation method of fig oral spray, comprising the following steps:
1. the preparation of fig fruit extract freeze-drying powder:
(1.1) high-quality fresh fig fruit is selected, after rinsing well, is put into freeze dryer and is lyophilized；
(1.2) fig fruit after freeze-drying is shredded, is put into pulverizer and is ground into powder, crosses 60 meshes；
(1.3) dry fig fruit powder 140g is weighed, stainless steel is put into and extracts in kettle, is to extract with subcritical water
Liquid carries out Subcritical water chromotagraphy, extraction time 20min to the powder；Stainless steel extract kettle in subcritical water pressure be
5MPa, temperature are 130 DEG C, flow velocity 7L/h；Obtain extract；
(1.4) said extracted object is obtained in 55 DEG C of vacuum distillation concentrate dryings containing fig polysaccharide, flavones and fiber
The multicomponent activity extract of element etc., and place it in be lyophilized in freeze dryer and fig fruit extract freeze-drying powder is made.
2. the preparation of fig leaf extract:
(2.1) good common fig leaf juice is selected, after rinsing well, is put into freeze dryer and is lyophilized；
(2.2) common fig leaf juice after freeze-drying is put into pulverizer and is ground into powder, cross 60 meshes；
(2.3) the common fig leaf juice powder 50g for weighing suitable drying is put into stainless steel and extracts in kettle, is with subcritical water
Extracting solution carries out Subcritical water chromotagraphy, extraction time 20min to the powder；Stainless steel extract kettle in subcritical water pressure be
5MPa, temperature are 130 DEG C, flow velocity 8L/h；Obtain fig leaf extract；
(2.4) fig leaf extract is obtained into the extract containing psoralen in 55 DEG C of vacuum distillation concentrate dryings,
And place it in be lyophilized in freeze dryer and fig leaf extract freeze-dried powder is made, it stores for future use.
3. the preparation of clinopodium grass saponin(e:
(3.1) it weighs clinopodium grass coarse powder 100g to be placed in ground triangular flask, 80% ethyl alcohol of mass percentage concentration is added
Aqueous solution 1000mL, ultrasound mention 30min, filter to get filtrate, and filter residue is added with 80% ethanol water of 1000mL mass percentage concentration,
Ultrasonic extraction 30min is repeated, filtering merges filtrate twice, obtains filtrate；
(3.2) filtrate is concentrated under reduced pressure to give clinopodium grass saponin extract at 30 DEG C, and places it in freeze dryer and freezes
It is drying to obtain clinopodium grass saponin(e freeze-dried powder, it stores for future use.
4. the preparation of fig spray:
A. 45g clinopodium grass saponin(e freeze-dried powder and 15g Irish moss (chondrux) sodium are taken, the promotor that is absorbed is uniformly mixed
60g。
B. fig leaf extract freeze-dried powder 4g and appropriate amount of deionized water is taken to be mixed and stirred in 250mL beaker uniformly,
It is uniformly mixed to prepare mixed solution A with 60g sorbefacient again.
C. 80g fig fruit extract freeze-drying powder is added into mixed solution A to be uniformly mixed, obtains mixed solution B.
D. deionized water being added in mixed solution B and being settled to 1000mL, fig mouth is obtained after biofilter filters
Spray obtained is filled into sprayer by chamber spray, obtains fig oral spray product.
Embodiment 3
The preparation method of fig oral spray, comprising the following steps:
1. the preparation of fig fruit extract freeze-drying powder:
(1.1) high-quality fresh fig fruit is selected, after rinsing well, is put into freeze dryer and is lyophilized；
(1.2) fig fruit after freeze-drying is shredded, is put into pulverizer and is ground into powder, crosses 60 meshes；
(1.3) dry fig fruit powder 180g is weighed, stainless steel is put into and extracts in kettle, is to extract with subcritical water
Liquid carries out Subcritical water chromotagraphy, extraction time 25min to the powder；Stainless steel extract kettle in subcritical water pressure be
6MPa, temperature are 150 DEG C, flow velocity 8L/h；Obtain extract；
(1.4) said extracted object is obtained in 55 DEG C of vacuum distillation concentrate dryings containing fig polysaccharide, flavones and fiber
The multicomponent activity extract of element etc., and place it in be lyophilized in freeze dryer and fig fruit extract freeze-drying powder is made.
Clinopodium grass saponin(e freeze-dried powder and fig leaf extract freeze-dried powder are the same as embodiment 2.
2. the preparation of fig spray:
A. 54g clinopodium grass saponin(e freeze-dried powder and 18g Irish moss (chondrux) sodium are taken, the promotor that is absorbed is uniformly mixed
72g。
B. fig leaf extract freeze-dried powder 2g and appropriate amount of deionized water is taken to be mixed and stirred in 250mL beaker uniformly,
It is uniformly mixed to prepare mixed solution A with 72g sorbefacient again.
C. 120g fig fruit extract freeze-drying powder is added into mixed solution A to be uniformly mixed, obtains mixed solution B.
D. deionized water being added in mixed solution B and being settled to 1000mL, fig mouth is obtained after biofilter filters
Spray obtained is filled into sprayer by chamber spray, obtains fig oral spray product.
Embodiment 4
The preparation method of fig oral spray, comprising the following steps:
1. the preparation of fig fruit extract freeze-drying powder:
(1.1) high-quality fresh fig fruit is selected, after rinsing well, is put into freeze dryer and is lyophilized；
(1.2) fig fruit after freeze-drying is shredded, is put into pulverizer and is ground into powder, crosses 60 meshes；
(1.3) dry fig fruit powder 200g is weighed, stainless steel is put into and extracts in kettle, is to extract with subcritical water
Liquid carries out Subcritical water chromotagraphy, extraction time 30min to the powder；Stainless steel extract kettle in subcritical water pressure be
6MPa, temperature are 160 DEG C, flow velocity 8L/h；Obtain extract；
(1.4) said extracted object is obtained in 55 DEG C of vacuum distillation concentrate dryings containing fig polysaccharide, flavones and fiber
The multicomponent activity extract of element etc., and place it in be lyophilized in freeze dryer and fig fruit extract freeze-drying powder is made.
Clinopodium grass saponin(e freeze-dried powder and fig leaf extract freeze-dried powder are the same as embodiment 2.
2. the preparation of fig spray:
A. 30g clinopodium grass saponin(e freeze-dried powder and 10g Irish moss (chondrux) sodium are taken, the promotor that is absorbed is uniformly mixed
40g。
B. fig leaf extract freeze-dried powder 5g and appropriate amount of deionized water is taken to be mixed and stirred in 250mL beaker uniformly,
It is uniformly mixed to prepare mixed solution A with 40g sorbefacient again.
C. 150g fig fruit extract freeze-drying powder is added into mixed solution A to be uniformly mixed, obtains mixed solution B.
D. deionized water being added in mixed solution B and being settled to 1000mL, fig mouth is obtained after biofilter filters
Spray obtained is filled into sprayer by chamber spray, obtains fig oral spray product.
Embodiment 5
The preparation method of fig oral spray, comprising the following steps:
1. the preparation of fig fruit extract freeze-drying powder:
(1.1) high-quality fresh fig fruit is selected, after rinsing well, is put into freeze dryer and is lyophilized；
(1.2) fig fruit after freeze-drying is shredded, is put into pulverizer and is ground into powder, crosses 60 meshes；
(1.3) dry fig fruit powder 100g is weighed, stainless steel is put into and extracts in kettle, is to extract with subcritical water
Liquid carries out Subcritical water chromotagraphy, extraction time 40min to the powder；Stainless steel extract kettle in subcritical water pressure be
7MPa, temperature are 180 DEG C, flow velocity 10L/h；Obtain extract；
(1.4) said extracted object is obtained in 55 DEG C of vacuum distillation concentrate dryings containing fig polysaccharide, flavones and fiber
The multicomponent activity extract of element etc., and place it in be lyophilized in freeze dryer and fig fruit extract freeze-drying powder is made.
Clinopodium grass saponin(e and fig leaf extract freeze-dried powder are the same as embodiment 1.
2. the preparation of fig spray:
A. 60g clinopodium grass saponin(e and 20g Irish moss (chondrux) sodium are taken, the promotor 80g that is absorbed is uniformly mixed.
B. fig leaf extract freeze-dried powder 2g and appropriate amount of deionized water is taken to be mixed and stirred in 250mL beaker uniformly,
It is uniformly mixed to prepare mixed solution A with 80g sorbefacient again.
C. 50g fig fruit extract freeze-drying powder is added into mixed solution A to be uniformly mixed, obtains mixed solution B.
D. deionized water being added in mixed solution B and being settled to 1000mL, fig mouth is obtained after biofilter filters
Spray obtained is filled into sprayer by chamber spray, obtains fig oral spray product.
Comparative example 1 (using high concentration cholate as single sorbefacient)
Fig fruit extract freeze-drying powder and fig leaf extract freeze-dried powder are the same as embodiment 1.
The preparation of fig spray:
By 6g fig leaf extract freeze-dried powder, 70g fig fruit extract freeze-drying powder and 60g sorbefacient ox sulphur
Chenodesoxycholic acid sodium is uniformly mixed with appropriate amount of deionized water, and addition deionized water is settled to 1000mL, is filtered through biofilter
Comparison fig oral spray is obtained afterwards.
Comparative example 2 (using clinopodium grass saponin(e as single sorbefacient)
Fig fruit extract freeze-drying powder, clinopodium grass saponin(e freeze-dried powder and the same embodiment of fig leaf extract freeze-dried powder
1。
The preparation of fig spray:
By 6g fig leaf extract freeze-dried powder, 70g fig fruit extract freeze-drying powder and 60g sorbefacient wind wheel
Careless saponin(e freeze-dried powder is uniformly mixed with appropriate amount of deionized water, and addition deionized water is settled to 1000mL, is filtered through biofilter
Comparison fig oral spray is obtained afterwards.
Testing example 1
This testing example measures the safety of fig oral spray of the invention.
The fig oral spray of embodiment 1-5 is subjected to stomach-filling experiment to mouse (C57 mouse, 18-22g), daily
0.5mL continuous 30 days, has no that mouse Novel presentation, absolute organ coefficient and opposite organ coefficient are showed no significant change.
Testing example 2
This testing example measures the anti-microbial property of fig oral spray of the invention.
By staphylococcus aureus (being purchased from ATCC, article No. 29213), in LB culture medium, (tryptone 10g/L, yeast are extracted
Object 5g/L, sodium chloride 10g/L) in culture to logarithmic phase, adjust cell concentration to 10 with LB culture medium6A/L, as containing golden
The bacterium solution of staphylococcus aureus.
The fig oral spray of embodiment 1-5, the fig mouth of comparative example 1-2 are separately added into the bacterium solution of 10m
Each 0.5mL of chamber spray is cultivated 6 hours at 37 DEG C, obtain it is antibacterial after sample.
It is right according to method specified in GB4789.10-2010 (inspection of food microbiological examination staphylococcus aureus)
It is above-mentioned it is antibacterial after sample carry out colony counting method viable bacteria body number detection, the results are shown in Table 1.
Table 1
According to the data of table 1 as it can be seen that fig oral spray of the invention has effective fungistatic effect and antibacterial effect
Fruit is significant, also, contains Fructus Fici extract freeze-dried powder, the 2g/L- of 80g/L-150g/L in preferred fig oral spray
The fungistatic effect that the preservative of 5g/L, the sorbefacient of 40g/L-72g/L have is more obvious.
Testing example 3
The present embodiment measures the effect of the treatment oral cavity and throat inflammation of fig oral spray of the invention.
It is anesthetized with ether cavy, a cotton pellet is placed in glass tube one end (being allowed to concordant with nozzle) that diameter is 5mm, then
Glass pipe close cotton balls one end is dipped in the phenol solution of 90% volume, calcination cavy left side cheek 60s is observed, cavy oral cavity afterwards for 24 hours
Occurs the sphagitis of diameter 5mm on mucous membrane, i.e. acquisition oral cavity and throat inflammation animal model.
Dip the fig oral cavity spray of the fig oral spray, comparative example 1-2 of embodiment 1-5 respectively with Disinfectant absorbent cotton
Each 0.3mL of mist agent is placed on 5min at cavy oral cavity and throat inflammation, each primary daily morning and evening.
Cavy oral cavity and throat inflammation situation was recorded with digital picture head respectively at the 3rd, 5,7 day, for observing mouse sphagitis
Healing situation.The 2h after last 1 medication of each period after evaluating cavy oral cavity and throat inflammation degree by judgment criteria, puts to death globefish
Mouse removes oral cavity and throat part, and 100g/L formalin is fixed, paraffin embedding, slice, microscopy, the pharynx of observation each group cavy oral cavity
Larynx tissue morphology situation.
Sphagitis degree judgment criteria: " O " without sphagitis, mucous membrane of mouth is normal；" I " has sphagitis, and throat surface is without bright
Aobvious redness phenomenon；" II " has sphagitis, and there is very thin secretion on throat surface, around without obvious red and swollen；" III " has sphagitis, pharynx
Larynx surface secretion is more, and surrounding is with mild inflammatory swelling；" IV " has sphagitis, and throat surface secretion is more, surrounding
With obvious inflammatory congestion swelling phenomenon.
Symptoms of the guinea pig model oral cavity and throat in different cycles are as shown in table 2.
Table 2
According to the data of table 2 as it can be seen that fig oral spray of the invention has good treatment oral cavity and throat inflammation
Effect and significant effect, also, contain the Fructus Fici extract freeze-drying of 80g/L-150g/L in preferred fig oral spray
Powder, the preservative of 2g/L-5g/L, 40g/L-72g/L sorbefacient in the case where, have more significant therapeutic effect.
With the fig oral spray in comparative example 1 using high concentration cholate as single sorbefacient, comparison
It is compared using clinopodium grass saponin(e as the fig oral spray of single sorbefacient in example 2, the present invention is used by wind wheel
The fig oral spray oral bacteriostasis for compounding sorbefacient of careless saponin(e and cholate composition, anti-inflammation detumescence effect are more
Significantly, can moistening lung to arrest cough, clearing away heat and moistening the bowels, removing toxicity for detumescence, popularization productive value with higher.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made.
The variation of parameter has no effect on the essential effect of product in inventive formulation.The change of parameter in preparation method of the present invention
Change and have no effect on the preparation of product and nor affect on the essential effect of product, thus in preparation method of the present invention arbitrary parameter combination
The preparation of product can be achieved.Details are not described herein.
Claims (7)
1. a kind of fig oral spray, which is characterized in that composed of the following components in terms of 1000mL:
Fig fruit extract freeze-drying powder 50g-150g；
Preservative 2g-6g；
Sorbefacient 40g-80g；
Surplus is deionized water；
The sorbefacient is made of clinopodium grass saponin(e and cholate；Clinopodium grass saponin(e and gallbladder in the sorbefacient
The mass ratio of hydrochlorate is 3:1；
The preservative is fig leaf extract.
2. fig oral spray according to claim 1, which is characterized in that in terms of 1000mL, by following components group
At:
Fig fruit extract freeze-drying powder 80g-150g；
Preservative 2g-5g；
Sorbefacient 40g-72g；
Surplus is deionized water.
3. fig oral spray according to claim 1, which is characterized in that the preparation side of the clinopodium grass saponin(e
Method, comprising the following steps:
Clinopodium grass is put into ultrasonic extraction 30min in the ethanol water of mass percentage concentration 80%, first-time filtrate is obtained by filtration,
Secondary filtrate is obtained by filtration in filter residue ultrasonic extraction 30min in the ethanol water of mass percentage concentration 80%, merges primary filter
Liquid and secondary filtrate obtain filtrate, and concentrating filter liquor, freeze-drying obtain clinopodium grass saponin extract.
4. fig oral spray according to claim 1, which is characterized in that the system of the fig leaf extract
Preparation Method, comprising the following steps:
Common fig leaf juice is cleaned, obtains common fig leaf juice powder after freeze-drying and crushing；By common fig leaf juice powder with subcritical water be mention
Liquid is taken to carry out Subcritical water chromotagraphy, extraction time 20min；Subcritical water pressure is 5MPa, and temperature is 130 DEG C, flow velocity 8L/
h；The concentrated drying of obtained extract, freeze-drying, obtain fig leaf extract.
5. fig oral spray according to claim 1 or 2, which is characterized in that the fig fruit extracts
The preparation method of object freeze-dried powder, comprising the following steps:
Fig fruit is cleaned, obtains fig fruit powder after freeze-drying and crushing；By fig fruit powder with subcritical
Water is that extracting solution carries out Subcritical water chromotagraphy, extraction time 10min-40min；Subcritical water pressure is 4MPa-7MPa, temperature
It is 120 DEG C -180 DEG C, flow velocity 5L/h-10L/h；The concentrated drying of obtained extract, freeze-drying obtain fig fruit extraction
Object freeze-dried powder.
6. fig oral spray according to claim 1, which is characterized in that the cholate is selected sweet
One of ammonia sodium taurocholate, glycochenodeoxycholate sodium, natrium taurocholicum, Irish moss (chondrux) sodium, NaTDC or two
Kind or more.
7. the preparation method of fig oral spray according to claim 1-6, which is characterized in that including with
Lower step:
(1) clinopodium grass saponin(e is uniformly mixed the promotor that is absorbed with cholate；
(2) sorbefacient, preservative and appropriate amount of deionized water are uniformly mixed, mixed solution A is made；
(3) fig fruit extract freeze-drying powder is added into mixed solution A, is uniformly mixed, obtains mixed solution B；
(4) deionized water being added in mixed solution B and being settled to 1000mL, fig oral spray is obtained after filter bacteria.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593480A (en) * | 2004-07-02 | 2005-03-16 | 陈小保 | Fig buccal tablet and its preparing process |
| CN101623304A (en) * | 2009-01-22 | 2010-01-13 | 九芝堂股份有限公司 | Pharmaceutical composition for nasal administration |
| CN101797289A (en) * | 2010-04-07 | 2010-08-11 | 西北大学 | Oral spraying agent prepared from traditional Chinese medicine and preparation method thereof |
| CN105770658A (en) * | 2016-05-17 | 2016-07-20 | 上饶市莎江高科生物有限公司 | Traditional Chinese medicine preparation for treating oral disease |
| CN105998542A (en) * | 2016-05-26 | 2016-10-12 | 孙明香 | Traditional Chinese medicine spray for treating acute laryngopharyngitis and preparation method of traditional Chinese medicine spray |
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2016
- 2016-11-30 CN CN201611077374.9A patent/CN106511471B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593480A (en) * | 2004-07-02 | 2005-03-16 | 陈小保 | Fig buccal tablet and its preparing process |
| CN101623304A (en) * | 2009-01-22 | 2010-01-13 | 九芝堂股份有限公司 | Pharmaceutical composition for nasal administration |
| CN101797289A (en) * | 2010-04-07 | 2010-08-11 | 西北大学 | Oral spraying agent prepared from traditional Chinese medicine and preparation method thereof |
| CN105770658A (en) * | 2016-05-17 | 2016-07-20 | 上饶市莎江高科生物有限公司 | Traditional Chinese medicine preparation for treating oral disease |
| CN105998542A (en) * | 2016-05-26 | 2016-10-12 | 孙明香 | Traditional Chinese medicine spray for treating acute laryngopharyngitis and preparation method of traditional Chinese medicine spray |
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