CN111802409B - Broad-spectrum antiviral antibacterial disinfectant and preparation method and application thereof - Google Patents
Broad-spectrum antiviral antibacterial disinfectant and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
Abstract
The invention discloses a broad-spectrum antiviral and antibacterial disinfectant, which comprises the following raw materials in parts by weight: 1-50 parts of N-alkyl propylamine glycine, 10-50 parts of active matrix material, 1-100 parts of film forming agent, 1-100 parts of thickening agent, 1-10 parts of plant extracting agent, 1-10 parts of solubilizer and 1-10 parts of freshener; the active matrix material is a mixture of carrageenan and chitosan sulfate. The broad-spectrum antiviral and antibacterial disinfectant has good bactericidal and bacteriostatic effects, long duration and no toxicity to human bodies, and has strong bactericidal effects on various epidemic diseases such as novel coronavirus, hepatitis virus, AIDS virus, avian influenza virus, influenza A virus, vaccinia virus, escherichia coli, candida, salmonella enteritidis, candida albicans, staphylococcus aureus and the like. The invention also discloses a preparation method and application of the broad-spectrum antiviral and antibacterial disinfectant.
Description
Technical Field
The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a broad-spectrum antiviral and antibacterial disinfectant, and a preparation method and application thereof.
Background
The novel coronavirus is rough in epidemic situation, is in epidemic prevention stage all over the world, and is very concerned about protection and treatment of the virus. The novel coronavirus transmission mode is droplet, aerosol, fecal oral cavity and contact transmission, and the novel coronavirus can survive for 5 days in an environment with proper temperature and humidity, so that the novel coronavirus is very easy to cause interpersonal transmission and epidemic. Cutting off the transmission path becomes an important measure for preventing the virus transmission epidemic.
The disinfectant mainly used at present comprises chlorine-containing disinfectant (including hypochlorous acid, chlorine dioxide and the like), peroxyacetic acid, alcohol and the like. But chlorine-containing disinfectants (including hypochlorous acid, chlorine dioxide, etc.) and peroxyacetic acid, etc. But the chlorine-containing disinfectant has strong oxidizing property, irritation, instability and difficult degradability, also has the malignant effects of carcinogenesis and mutagenesis, and is easy to generate harmful substances such as dioxin and the like in the using process; if the fertilizer is used at high frequency and high concentration, the fertilizer can cause damage to flowers, plants, trees, water, soil and crops, and directly or indirectly affect human health. The peroxyacetic acid is similarly unstable, needs to be prepared at present, is easy to decompose in the environment, has long waiting time during sterilization and disinfection, and has short sterilization and disinfection action time and single function. In addition, both chlorine-containing disinfectants and peracetic acid disinfectants can only be used for disinfecting articles, but not for human bodies. The only alcohol disinfectant which can be used for human bodies has the defects that the effective components are easy to volatilize, the sterilization performance is reduced, and the alcohol disinfectant has irritation to the skin, and can cause accidents such as burning or fire and the like when meeting open fire. And most of the disinfectants used at present have poor broad-spectrum sterilization, and are aimed at certain types or certain fungi, and have poor killing effect on other fungi.
Therefore, the research of a comprehensive broad-spectrum antiviral and antibacterial disinfectant with good bactericidal effect, strong durability, no toxicity or low toxicity is urgently needed.
Disclosure of Invention
The invention aims to overcome the technical defects, and the invention aims to provide a broad-spectrum antiviral and antibacterial disinfectant which has good bactericidal and bacteriostatic effects, long duration and no toxicity to human bodies, has strong bactericidal effects on various epidemic infectious diseases such as novel coronavirus, hepatitis virus, AIDS virus, avian influenza virus, influenza A virus, vaccinia virus, escherichia coli, candida, salmonella enteritidis, candida albicans, staphylococcus aureus and the like, and solves the technical problems that the existing disinfectant has poor bactericidal effect, short duration, toxic effects on human bodies and single effect; the second aspect of the invention aims to provide a preparation method of the broad-spectrum antiviral and antibacterial disinfectant, which is simple to operate and suitable for industrial mass production; the third aspect of the invention aims to provide the application of the broad-spectrum antiviral and antibacterial disinfectant.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides a broad-spectrum antiviral and antibacterial disinfectant, which comprises the following raw materials in parts by weight:
1-50 parts of N-alkyl propylamine glycine
10-50 parts of active matrix material
1-100 parts of film forming agent
1-100 parts of thickening agent
1-10 parts of plant extractant
1-10 parts of solubilizer
1-10 parts of a freshener;
wherein the active matrix material is a mixture of carrageenan and chitosan sulfate.
In a second aspect, the present invention provides a method for preparing a broad-spectrum antiviral and antibacterial disinfectant, comprising the steps of:
preparing materials according to parts by weight;
mixing N-alkyl propylamine glycine, an active matrix material, a film forming agent, a thickening agent, a plant extracting agent, a solubilizer, a freshener and water, and mixing for 3-6 hours at normal temperature to obtain a finished product.
In a third aspect, the invention provides the use of a broad-spectrum antiviral, antibacterial disinfectant.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the broad-spectrum antiviral and antibacterial disinfectant provided by the invention, the active matrix material can improve the wettability and affinity of N-alkyl propylamine glycine and improve the antibacterial durability of the disinfectant, and meanwhile, the sugar-peptide composition synergistic effect between the N-alkyl propylamine glycine and the active matrix material can further stimulate the antibacterial performance of the N-alkyl propylamine glycine and enhance the antibacterial and bacteriostatic performance of the N-alkyl propylamine glycine; the film forming agent and the thickening agent can form a protective film to prolong the action time of the disinfectant, the plant extract and the freshener can further improve the disinfection and bacteriostasis effects of the disinfectant, and the solubilizer can enable the active matrix material and the N-alkyl propylamine glycine to be mixed uniformly; the antiviral and antibacterial disinfectant provided by the invention has the advantages that through the synergistic effect of various substances, a protective film is formed on the surface of an object to be sterilized, and the continuous antibacterial and bacteriostatic effects are achieved;
2. the broad-spectrum antiviral antibacterial disinfectant provided by the invention has a strong bactericidal effect on various epidemic diseases such as novel coronavirus, hepatitis virus, HIV, avian influenza virus, influenza A virus, vaccinia virus, escherichia coli, candida, salmonella enteritidis, candida albicans, staphylococcus aureus and the like, and the duration of sterilization and bacteriostasis is long;
3. the N-alkyl propylamine glycine in the broad-spectrum antiviral and antibacterial disinfectant provided by the invention is an amphoteric amino acid type surfactant with a disinfecting function, does not contain aldehydes and active chlorine agent alkali components, is harmless to a human body, is healthy and environment-friendly, has extremely low residue and no corrosiveness, and is pollution-free, biodegradable, hard water and organic matter resistant and can keep high activity at low temperature; the broad-spectrum antiviral antibacterial disinfectant provided by the invention can replace ethanol disinfectant and chlorine-containing disinfectant, has a good disinfection effect, is environment-friendly and has good bacteriostatic ability.
4. The broad-spectrum antiviral antibacterial disinfectant provided by the invention is suitable for surface disinfection and epidemic area disinfection of objects in high-speed railways, steamships, airplanes, subways, hospitals, schools, kindergartens, large stadiums, large entertainment facilities, families and other public places;
5. the preparation method of the broad-spectrum antiviral antibacterial disinfectant provided by the invention is simple to operate and is suitable for industrial mass production.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The embodiment of the invention provides a broad-spectrum antiviral and antibacterial disinfectant, which comprises the following raw materials in parts by weight:
1-50 parts of N-alkyl propylamine glycine
10-50 parts of active matrix material
1-100 parts of film forming agent
1-100 parts of thickening agent
1-10 parts of plant extract
1-10 parts of solubilizer
1-10 parts of a freshener;
wherein the active matrix material is a mixture of carrageenan and chitosan sulfate.
The content of N-Alkyl aminopropyl glycine (N-Alkyl aminopropyl glycine) may be 1 part, 5 parts, 10 parts, 20 parts, 30 parts, 40 parts or 50 parts, but is not limited to the listed values, and other values not listed in the listed value range are also applicable; the active matrix material may be present in an amount of 10 parts, 20 parts, 30 parts, 40 parts, or 50 parts, etc., but is not limited to the recited values, and other unrecited values within the recited range of values are equally applicable; the amount of film former may be 1 part, 10 parts, 20 parts, 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, 90 parts, 100 parts, etc., but is not limited to the recited values, and other values not recited within the listed ranges are equally applicable; the thickener may be present in an amount of 1 part, 10 parts, 20 parts, 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, 90 parts, 100 parts, etc., but is not limited to the recited values, and other values not recited within the recited range of values are equally applicable; the amount of the plant extractant may be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, etc., but is not limited to the recited values, and other values not recited within the listed values are also applicable; the content of the solubilizer may be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts, etc., but is not limited to the enumerated values, and other unrecited values within the enumerated value range are also applicable; the cooling agent may be present in an amount of 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, or 10 parts, but is not limited to the recited amounts, and other unrecited amounts within the recited range of amounts are equally applicable.
The broad-spectrum antiviral and antibacterial disinfectant provided by the embodiment of the invention has the main active substance of N-alkyl propylamine glycine, the N-alkyl propylamine glycine enables cell walls and cytoplasmic membranes to be distorted, deformed and fragmented through charge adsorption and cell wall permeation, and then reacts with key proteins of cell life substances and enzymes which are used for leading cell respiration and glycolysis to enable cells to lose activity so as to achieve the antibacterial effect, but the disinfectant only containing the N-alkyl propylamine glycine has short antibacterial time. The inventor of the application improves the wettability and the affinity of the N-alkyl propylamino glycine material by adding the active matrix material, improves the antibacterial durability of the disinfectant, and simultaneously, the sugar-peptide composition synergistic effect between the N-alkyl propylamino glycine and the active matrix material can further stimulate the antibacterial performance of the N-alkyl propylamino glycine and enhance the antibacterial and bacteriostatic performance of the N-alkyl propylamino glycine; the film forming agent and the thickening agent are added to form a protective film, so that the action time of the disinfectant is prolonged, the plant extract and the freshener can further improve the disinfection and bacteriostasis effects of the disinfectant, and the solubilizer can enable the active matrix material and the N-alkyl propylamine glycine to be mixed uniformly; the inventor of the application combines good antibacterial property and durability of the antiviral and antibacterial disinfectant through the synergistic effect of the N-alkyl propylamine glycine, the active matrix material and various auxiliary agents.
In some preferred embodiments of the present invention, the active matrix material is carrageenan and chitosan sulfate in a molar ratio of 1: 1-4, for example 1: 1. 1: 2. 1:3 or 1:4, etc., but are not limited to the recited values, and other values not recited within the numerical range are equally applicable. The antibacterial performance of the N-alkyl propylamine glycine is better promoted by optimizing the molar ratio of the carrageenan to the chitosan sulfate in the active matrix material.
More preferably, the active matrix material is carrageenan and chitosan sulfate in a molar ratio of 1:2, mixing to obtain the product.
In some preferred embodiments of the invention, the mass ratio of N-alkyl propylaminylglycine to active matrix material is 1: 1. The disinfecting and antibacterial performance of the disinfectant is further improved by optimizing the mass ratio of the N-alkyl propylamine glycine to the active matrix material.
In some preferred embodiments of the invention, the film former is at least one of polyvinyl alcohol, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, propylene glycol butyl ether, propylene glycol methyl ether acetate, diacetone alcohol, and dipropylene glycol dimethyl ether, and may be, for example, a mixture of polyvinyl alcohol and 2,2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, a mixture of propylene glycol butyl ether and propylene glycol methyl ether acetate, a mixture of diacetone alcohol and dipropylene glycol dimethyl ether, a mixture of polyvinyl alcohol, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, and propylene glycol butyl ether, polyvinyl alcohol, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, propylene glycol butyl ether, Mixtures of propylene glycol methyl ether acetate, diacetone alcohol and dipropylene glycol dimethyl ether, and the like, but are not limited to the combinations listed, and other single substances or combinations not listed are also applicable.
More preferably, the film former is 2,2, 4-trimethyl-1, 3-pentanediol monoisobutyrate.
In some preferred embodiments of the present invention, the thickener is at least one of carboxymethyl cellulose, propylene glycol alginate, methyl cellulose, sodium starch phosphate, sodium carboxymethyl cellulose, sodium alginate, casein, sodium polyacrylate, polyoxyethylene, and polyvinylpyrrolidone. For example, a mixture of carboxymethylcellulose and propylene glycol alginate, a mixture of methylcellulose and sodium starch phosphate, a mixture of sodium starch phosphate, sodium carboxymethylcellulose and sodium alginate, a mixture of casein and sodium polyacrylate, a mixture of polyoxyethylene and polyvinylpyrrolidone, and the like can be used, but the present invention is not limited to the combinations listed, and other single substances or combinations not listed are also applicable.
More preferably, the thickener is carboxymethyl cellulose.
In some preferred embodiments of the present invention, the plant extract is at least one of green tea extract, aloe vera extract, centella asiatica extract, lavender extract, lemon extract, peach extract, sage extract, ginkgo biloba extract and honeysuckle extract. For example, a mixture of green tea extract and aloe extract, a mixture of aloe extract, centella extract and lavender extract, a mixture of lemon extract and peach extract, a mixture of sage extract, ginkgo biloba extract and honeysuckle extract, but not limited to the combinations listed, and other non-listed single substances or combinations are equally suitable.
More preferably, the plant extract is green tea extract.
In some preferred embodiments of the present invention, the solubilizer is at least one of polyoxyethylene castor oil, laurate, polyglycerol fatty acid ester, polyoxyethylene hardened castor oil, fatty alcohol-polyoxyethylene ether, fatty alcohol-polyoxyethylene-polyoxypropylene ether, polyoxyethylene sorbitan fatty acid ester, and tween-40. For example, a mixture of polyoxyethylene castor oil and laurate, a mixture of polyglycerin fatty acid ester, polyoxyethylene hardened castor oil and fatty alcohol polyoxyethylene ether, a mixture of fatty alcohol polyoxyethylene-polyoxypropylene ether, polyoxyethylene sorbitan fatty acid ester and tween-40, but not limited to the combinations listed, and other single substances or combinations not listed are also applicable.
More preferably, the solubilizer is polyoxyethylated castor oil.
In some preferred embodiments of the invention, the cooling agent is at least one of synthetic borneol, menthol anthranilate, menthol lactate, menthol acetate, menthaneformylethylamine, menthoxypropanediol, 8-methoxycoumarin-3-carboxylic acid menthyl ester, monomenthyl glutarate, N-ethyl-p-menthane-3-carboxamide, and L-menthyl- β -D-lactoside. For example, a mixture of synthetic borneol and menthol anthranilate, a mixture of menthol lactate, menthol acetate and menthaneformylethylamine, a mixture of menthoxypropanediol and 8-methoxycoumarin-3-carboxylic acid menthyl ester, a mixture of monomenthyl glutarate, N-ethyl-p-menthane-3-carboxamide and L-menthyl-beta-D-lactoside, but not limited to the combinations listed, other single substances or combinations not listed are equally suitable.
More preferably, the cooling agent is synthetic borneol.
The invention optimizes the types of the auxiliary agents such as the film forming agent, the thickening agent, the solubilizer, the freshener and the like to ensure that the active matrix material is more stably and uniformly dispersed in the N-alkyl propylamine glycine, the film forming durability of the protective film is improved, the synthesized borneol also has good antibacterial and antifungal effects, and has obvious inhibiting effect on staphylococcus aureus, staphylococcus albus and drug-resistant staphylococcus aureus, the plant extract, particularly the green tea extract in the plant extract, can inhibit and kill various pathogenic bacteria such as common proteus, staphylococcus aureus, staphylococcus epidermidis, streptococcus mutans, clostridium botulinum, lactobacillus, vibrio cholerae, oral cavity streptococcus mutans and the like, particularly intestinal pathogenic bacteria to different degrees, can effectively prevent the infection of the antibiotic-resistant staphylococcus, and also has inhibiting activity on hemolysin, the tea polyphenol contained in the tea also has strong inhibiting effect on pathogenic fungi which can cause skin diseases of human bodies. By optimizing various auxiliary agents and the types of plant extracts, the wettability and the affinity of the N-alkyl propylamino glycine are further improved, the film forming durability of the protective film is longer, the sterilization duration is longer, and the sterilization and antibacterial performance of the disinfectant is optimal.
In some preferred embodiments of the present invention, the broad-spectrum antiviral and antibacterial disinfectant comprises the following raw materials in parts by weight:
10 parts of N-alkyl propylamine glycine
Active matrix material 10 parts
20 parts of 2,2, 4-trimethyl-1, 3-pentanediol monoisobutyrate
15 portions of carboxymethyl cellulose
6 parts of green tea extracting agent
5 portions of polyoxyethylene castor oil
5 parts of synthetic borneol;
wherein the active matrix material is prepared from carrageenan and chitosan sulfate according to a molar ratio of 1:2, mixing the mixture.
In the embodiment of the invention, the broad-spectrum antiviral and antibacterial disinfectant also contains water.
More preferably, the broad-spectrum antiviral and antibacterial disinfectant comprises the following raw materials by weight per liter:
n-alkyl propylamino glycine 10g
Active matrix Material 10g
2,2, 4-trimethyl-1, 3-pentanediol monoisobutyrate 20g
Carboxymethyl cellulose 15g
Green tea extracting agent 6g
Polyoxyethylene Castor oil 5g
Synthetic borneol 5g
The balance of water;
wherein the active matrix material is prepared from carrageenan and chitosan sulfate according to a molar ratio of 1:2, mixing the mixture.
The broad-spectrum antiviral and antibacterial disinfectant provided by the embodiment of the invention can be further added with essence and/or humectant to increase the moisture retention of the disinfectant and adjust the odor of the disinfectant, and a person skilled in the art can select specific types of the essence and the humectant according to actual needs, which is not further limited by the invention.
The embodiment of the invention also provides a preparation method of the broad-spectrum antiviral and antibacterial disinfectant, which comprises the following steps:
(1) preparing materials according to parts by weight;
(2) mixing N-alkyl propylamine glycine, active matrix material, film-forming agent, thickening agent, plant extracting agent and thickener
And mixing the solvent, the freshener and water, and mixing for 3-6 hours at normal temperature to obtain a finished product.
In the embodiment of the present invention, the mixing is performed by stirring, and the stirring time may be 3 hours, 4 hours, 5 hours, or 6 hours, but is not limited to the values listed, and other values not listed in the range of the values are also applicable.
The embodiment of the invention also provides application of the broad-spectrum antiviral and antibacterial disinfectant.
In embodiments of the invention, the broad spectrum antiviral antimicrobial disinfectant is used for disinfection of novel coronaviruses, hepatitis viruses, aids viruses, avian influenza viruses, influenza a viruses, vaccinia viruses, escherichia coli, candida, salmonella enteritidis, candida albicans, and staphylococcus aureus.
It should be noted that, when the broad-spectrum antiviral and antibacterial disinfectant provided by the embodiment of the present invention is applied, a user can adjust the usage amount and usage concentration thereof according to actual needs, and can directly use or dilute the disinfectant stock solution, and the usage amount and usage concentration thereof are not further limited by the present invention.
The broad-spectrum antiviral and antibacterial disinfectant provided by the embodiment of the invention can be directly sprayed on the surface of an object to be sterilized and can also be directly acted on the skin of a hand of a human body.
In order to further illustrate the present invention, the following examples are given to further illustrate the present invention. The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified; materials, reagents and the like used in examples of the present invention are commercially available unless otherwise specified.
Example 1:
example 1 of the present invention provides a broad-spectrum antiviral and antibacterial disinfectant, which comprises the following raw materials per liter:
10g of N-alkyl propylamine glycine, 10g of active matrix material, 20g of film-forming agent 2,2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, 15g of thickening agent carboxymethyl cellulose, 6g of plant extract green tea extract, 5g of solubilizer polyoxyethylene castor oil and 5g of freshener synthetic borneol, and the balance of purified water;
the active matrix material is prepared by mixing carrageenan and chitosan sulfate, wherein the molar ratio of the carrageenan to the chitosan sulfate is 1: 2.
The broad-spectrum antiviral and antibacterial disinfectant is prepared by the following method:
(1) preparing materials according to parts by weight;
(2) mixing N-alkyl propylamine glycine, an active matrix material, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, carboxymethyl cellulose, a green tea extract, polyoxyethylene castor oil, synthetic borneol and purified water, and stirring and mixing for 4.5 hours at normal temperature to obtain a finished product.
Example 2:
the embodiment 2 of the invention provides a broad-spectrum antiviral and antibacterial disinfectant, and each liter of the broad-spectrum antiviral and antibacterial disinfectant comprises the following raw materials in parts by weight:
14g of N-alkyl propylamine glycine, 24g of active matrix material, 10g of film-forming agent polyvinyl alcohol, 18g of thickening agent propylene glycol algae protein acid ester, 3g of plant extract aloe extract, 6g of solubilizer fatty alcohol-polyoxyethylene ether and 8g of freshener menthol acetate, and the balance being purified water;
the active matrix material is prepared by mixing carrageenan and chitosan sulfate, wherein the molar ratio of the carrageenan to the chitosan sulfate is 1: 1.
The preparation method of the broad-spectrum antiviral and antibacterial disinfectant is the same as that of example 1.
Example 3:
example 3 of the present invention provides a broad-spectrum antiviral and antibacterial disinfectant, which comprises the following raw materials per liter:
18g of N-alkyl propylamine glycine, 16g of active matrix material, 30g of film-forming agent propylene glycol butyl ether, 26g of thickening agent methyl cellulose, 5g of plant extract centella asiatica extractant, 8g of solubilizer laurate and 6g of cooling agent menthoxypropanediol, and the balance being purified water;
the active matrix material is prepared by mixing carrageenan and chitosan sulfate, wherein the molar ratio of the carrageenan to the chitosan sulfate is 1: 4.
The preparation method of the broad-spectrum antiviral and antibacterial disinfectant is the same as that of example 1.
Example 4:
embodiment 4 of the present invention provides a broad-spectrum antiviral and antibacterial disinfectant, which comprises the following raw materials per liter:
8g of N-alkyl propylamine glycine, 18g of active matrix material, 25g of film-forming agent propylene glycol methyl ether acetate, 16g of thickening agent sodium starch phosphate, 3g of plant extract lavender extractant, 6g of solubilizer polyoxyethylene hardened castor oil and 5g of cooling agent menthol lactate, and the balance of purified water;
the active matrix material is prepared by mixing carrageenan and chitosan sulfate, wherein the molar ratio of the carrageenan to the chitosan sulfate is 1: 3.
The preparation method of the broad-spectrum antiviral and antibacterial disinfectant is the same as that of example 1.
Example 5:
example 5 of the present invention provides a broad-spectrum antiviral and antibacterial disinfectant, which comprises the following raw materials per liter:
16g of N-alkyl propylamine glycine, 35g of active matrix material, 20g of diacetone alcohol serving as a film forming agent, 15g of sodium carboxymethyl cellulose serving as a thickening agent, 9g of lemon extracting agent serving as a plant extract, 5g of polyglycerol fatty acid ester serving as a solubilizer, 6g of monomenthyl glutarate serving as a cooling agent and the balance of purified water;
the preparation method and the materials of the active matrix material are the same as those in the example 1.
The preparation method of the broad-spectrum antiviral and antibacterial disinfectant is the same as that of example 1.
Example 6:
example 6 of the present invention provides a broad-spectrum antiviral and antibacterial disinfectant, which comprises the following raw materials per liter:
35g of N-alkyl propylamine glycine, 28g of active matrix material, 55g of film-forming agent dipropylene glycol dimethyl ether, 35g of thickening agent sodium alginate, 7g of plant extract ginkgo leaf extractant, 6g of solubilizer polyoxyethylene sorbitan fatty acid ester and 5g of cooling agent menthane formylethylamine, and the balance being purified water;
the preparation method and the materials of the active matrix material are the same as those in the example 1.
The preparation method of the broad-spectrum antiviral and antibacterial disinfectant is the same as that of example 1.
Comparative example 1:
this example provides an antimicrobial disinfectant having the same composition and content as in example 1, except that it does not contain an active matrix material.
Comparative example 2:
this example provides an antimicrobial disinfectant having the same composition and content as in example 1, except that 5g of active matrix material per liter of antimicrobial disinfectant was included.
The antibacterial disinfectants prepared in examples 1 to 6 and comparative examples 1 to 2 were subjected to performance tests.
The antibacterial disinfectants prepared in examples 1-6 and comparative examples 1-2 were tested for their bactericidal effect against the novel coronavirus (SARS-CoV-2), and the results of the tests are shown in Table 1, which was tested by the institute for Wuhan Virus, the national academy of sciences.
Table 1: performance test Table for antibacterial disinfectant described in examples 1 to 6 and comparative examples 1 to 2
| Sample concentration and treatment time | Survival rate (pfu/mL) | Sterilizing rate (%) | Duration of film formation | |
| Example 1 | 1% treatment for 1min | ＜10 | ＞99.99 | ＞48h |
| Example 2 | 1% treatment for 1min | ＜10 | ＞99.99 | ＞36h |
| Example 3 | 1% treatment for 1min | ＜10 | ＞99.99 | ＞36h |
| Example 4 | 1% treatment for 1min | ＜10 | ＞99.99 | ＞36h |
| Example 5 | 1% treatment for 1min | ＜10 | ＞99.99 | ＞36h |
| Example 6 | 1% treatment for 1min | ＜10 | ＞99.99 | ＞36h |
| Comparative example 1 | 1% treatment for 1min | 6.4×104 | 90～95 | ＜12h |
| Comparative example 2 | 1% treatment for 1min | 6.0×104 | 90～95 | ＜12h |
In order to further verify the killing capability of the antibacterial disinfectant provided by the invention on various viruses, the antibacterial disinfectant prepared in the embodiment 1 is selected to test various microorganisms to obtain test results shown in tables 2-11, wherein the test results are shown in tables 2-6, wherein the concentration x% is calculated by the original concentration of the antibacterial disinfectant, and the test conditions are that clean = low albumin content (0.03%)/dirty = high albumin content (0.3%), and the test results are obtained in a standardized manner; the concentrations x-ppm given in tables 7 to 11 were calculated as the original concentrations of the antibacterial agent, and the above experimental results were obtained by a standardized method.
Table 2: sterilizing effect on Hepatitis B Virus (HBV)
| Concentration% (clean) | Time/min | Concentration% (dirty) | Time/min | Reduced logarithmic value |
| 0.75 | 30 | 1.5 | 30 | 4 |
Table 3: sterilizing effect on Human Immunodeficiency Virus (HIV)
| Concentration% (clean) | Time/min | Concentration% (dirty) | Time/min | Reduced logarithmic value |
| 0.75 | 30 | 1.5 | 30 | 4 |
Table 4: bactericidal effect on avian influenza virus (BFV)
| Concentration% (clean) | Time/min | Concentration% (dirty) | Time/min | Reduced logarithmic value |
| 0.5 | 5 | 0.5 | 15 | 4 |
Table 5: bactericidal effect against influenza A virus (BFV)
| Concentration% (clean) | Time/min | Concentration% (dirty) | Time/min | Reduced logarithmic value |
| 0.5 | 5 | 0.5 | 15 | 4 |
Table 6: germicidal effect on Vaccinia Virus (VV)
| Concentration% (clean) | Time/min | Concentration% (dirty) | Time/min | Reduced logarithmic value |
| 0.5 | 5 | 0.5 | 5 | 4 |
Table 7: sterilizing effect on Escherichia coli
| Form(s) of | Concentration per ppm | Time/min | Reduced logarithmic value |
| All are | 840 | 5 | 5(EN1276) |
Table 8: bactericidal effect on staphylococcus aureus
| Form(s) of | Concentration per ppm | Time/min | Reduced logarithmic value |
| All are | 330 | 5 | 5(EN1276) |
Table 9: sterilizing effect on candida albicans
| Form(s) of | Concentration per ppm | Time/min | Reduced logarithmic value |
| All are | 250 | 15 | 4(EN1276) |
Table 10: sterilizing effect on salmonella enteritidis
| Form(s) of | Concentration per ppm | Time/min | Reduced logarithmic value |
| All are | 840 | 5 | 5 |
Table 11: sterilizing effect on candida
| Form(s) of | Concentration per ppm | Time/min | Reduced logarithmic value |
| All are | 1600 | 15 | 4 |
Note: all of tables 7 to 11 show the inclusion of spores and nutrients, and EN1276 shows the test criteria for bacterial testing.
As can be seen from tables 1 to 11, the antiviral and antibacterial disinfectant provided by the invention has good bactericidal and bacteriostatic effects, is long in duration, can play a role in continuous antibacterial and bacteriostatic action, and has strong bactericidal effects on various epidemic diseases such as novel coronavirus, hepatitis virus, HIV, avian influenza virus, influenza A virus, vaccinia virus, escherichia coli, candida, salmonella enteritidis, candida albicans, staphylococcus aureus and the like.
The above-described embodiments of the present invention should not be construed as limiting the scope of the present invention. Any other corresponding changes and modifications made according to the technical idea of the present invention should be included in the protection scope of the claims of the present invention.
Claims (8)
1. The broad-spectrum antiviral and antibacterial disinfectant is characterized by comprising the following raw materials in parts by weight:
1-50 parts of N-alkyl propylamine glycine
10-50 parts of active matrix material
1-100 parts of film forming agent
1-100 parts of thickening agent
1-10 parts of plant extract
1-10 parts of solubilizer
1-10 parts of a freshener;
wherein the active matrix material is a mixture of carrageenan and chitosan sulfate; the active matrix material is prepared from carrageenan and chitosan sulfate according to a molar ratio of 1: 1-4 of a mixture; the mass ratio of the N-alkyl propylamine glycine to the active matrix material is 1: 1.
2. The broad spectrum antiviral and antibacterial disinfectant of claim 1, wherein,
the film forming agent is at least one of polyvinyl alcohol, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, propylene glycol butyl ether, propylene glycol methyl ether acetate, diacetone alcohol and dipropylene glycol dimethyl ether;
the thickening agent is at least one of carboxymethyl cellulose, propylene glycol alginate, methyl cellulose, sodium starch phosphate, sodium carboxymethyl cellulose, sodium alginate, casein, sodium polyacrylate, polyoxyethylene and polyvinylpyrrolidone;
the solubilizer is at least one of polyoxyethylene castor oil, laurate, polyglycerol fatty acid ester, polyoxyethylene hardened castor oil, fatty alcohol-polyoxyethylene ether, fatty alcohol-polyoxyethylene-polyoxypropylene ether, polyoxyethylene sorbitan fatty acid ester and tween-40;
the algefacient is at least one of synthetic borneol, menthol anthranilate, menthol lactate, menthol acetate, menthane formylethylamine, menthoxypropanediol, 8-methoxycoumarin-3-menthyl formate, monomenthyl glutarate, N-ethyl-p-menthane-3-carboxamide and L-menthyl-beta-D-lactoside.
3. The broad spectrum antiviral and antibacterial disinfectant of claim 1, wherein said plant extract is at least one of green tea extract, aloe extract, centella asiatica extract, lavender extract, lemon extract, peach extract, sage extract, ginkgo biloba extract and honeysuckle extract.
4. The broad-spectrum antiviral and antibacterial disinfectant as claimed in any one of claims 1 to 3, wherein the broad-spectrum antiviral and antibacterial disinfectant comprises the following raw materials in parts by weight:
10 parts of N-alkyl propylamine glycine
Active matrix material 10 parts
20 parts of 2,2, 4-trimethyl-1, 3-pentanediol monoisobutyrate
15 portions of carboxymethyl cellulose
6 parts of green tea extracting agent
5 portions of polyoxyethylene castor oil
5 parts of synthetic borneol;
wherein the active matrix material is prepared from carrageenan and chitosan sulfate according to a molar ratio of 1:2, mixing the mixture.
5. The wide spectrum antiviral and antibacterial disinfectant of claim 4, further comprising water, wherein each liter of said wide spectrum antiviral and antibacterial disinfectant comprises the following raw materials by weight:
n-alkyl propylamino glycine 10g
Active matrix Material 10g
2,2, 4-trimethyl-1, 3-pentanediol monoisobutyrate 20g
Carboxymethyl cellulose 15g
Green tea extracting agent 6g
Polyoxyethylene Castor oil 5g
Synthetic borneol 5g
The balance of water;
wherein the active matrix material is prepared from carrageenan and chitosan sulfate according to a molar ratio of 1:2, mixing the mixture.
6. A process for the preparation of a broad spectrum anti-viral anti-bacterial disinfectant as claimed in any of claims 1 to 5, comprising the steps of:
preparing materials according to parts by weight;
mixing N-alkyl propylamine glycine, an active matrix material, a film forming agent, a thickening agent, a plant extracting agent, a solubilizer, a freshener and water, and mixing for 3-6 hours at normal temperature to obtain a finished product.
7. Use of a broad spectrum antiviral, antibacterial disinfectant as claimed in any one of claims 1 to 5.
8. Use of the broad spectrum anti-viral, anti-bacterial disinfectant according to claim 7, for the disinfection of novel coronaviruses, hepatitis viruses, aids viruses, avian influenza viruses, influenza a viruses, vaccinia viruses, escherichia coli, candida, salmonella enteritidis, candida albicans and staphylococcus aureus.
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| CN112471145A (en) * | 2020-12-04 | 2021-03-12 | 王立强 | Ultrahigh molecular solid slow-release disinfection bacteriostatic agent and preparation method thereof |
| CN112616861B (en) * | 2020-12-14 | 2021-10-01 | 杭州象外环保科技有限公司 | Novel natural plant extract essential oil coronavirus disinfectant and application thereof |
| CN114451426B (en) * | 2022-04-13 | 2022-07-15 | 山东健源生物科技有限公司 | Sterilizing and bacteriostatic biological compound preparation for improving livestock and poultry environment and preparation method thereof |
| CN115006348A (en) * | 2022-07-11 | 2022-09-06 | 振德医疗用品股份有限公司 | Long-acting spray for oral mucosa and nasal mucosa, preparation method and application |
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