CN112471145A - Ultrahigh molecular solid slow-release disinfection bacteriostatic agent and preparation method thereof - Google Patents
Ultrahigh molecular solid slow-release disinfection bacteriostatic agent and preparation method thereof Download PDFInfo
- Publication number
- CN112471145A CN112471145A CN202011405292.9A CN202011405292A CN112471145A CN 112471145 A CN112471145 A CN 112471145A CN 202011405292 A CN202011405292 A CN 202011405292A CN 112471145 A CN112471145 A CN 112471145A
- Authority
- CN
- China
- Prior art keywords
- percent
- release
- disinfection
- ultrahigh molecular
- bacteriostat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
Abstract
The invention provides an ultrahigh molecular solid slow-release disinfection bacteriostatic agent and a preparation method thereof, and is characterized in that: the composition comprises the following components in percentage by mass: 30-60% of ultra-high molecular composite polyethylene material, 30-60% of volatile disinfection and bacteriostasis liquid, 10-30% of diluent and 1-10% of controlled release film. The invention has the capability of long-acting disinfection and bacteriostasis, and can solve the problems of short duration, incomplete disinfection coverage (dead angle), inconvenient use and the like of the common liquid disinfectant. The invention is suitable for various living and public environments such as automobiles, buses, toilets, bedrooms, classrooms, offices and the like, saves the labor cost, and has simple preparation method, convenient use and low cost.
Description
Technical Field
The invention relates to the field of sanitation and disinfection, and provides an anti-virus ultra-high molecular weight solid sustained-release disinfection bacteriostatic agent which is prepared by adding a traditional Chinese medicine extract capable of disinfecting and bacteriostasis into the ultra-high molecular weight solid sustained-release agent.
Background
In our living environment, bacteria and viruses are almost ubiquitous, pathogenic bacteria harmful to human bodies are not lacked, and the new coronary pneumonia outbreak in 2019 requires that people pay more attention to personal and public environmental sanitation and safety in daily disinfection and sterilization to disinfect and sterilize the environment by methods such as chemical disinfectant, ultraviolet lamp and the like, but the methods have damage effects on human bodies and cannot be widely applied to daily living environment, and many disinfection and sterilization products have the defects of short disinfection and sterilization duration, incomplete disinfection and coverage, inconvenience in use and the like; therefore, a novel solid disinfection bacteriostatic agent which can be applied to various daily environments such as an automobile air conditioner, an indoor humidifier, a fresh air system and the like, has excellent disinfection and bacteriostasis effects, has a long-time disinfection effect and is convenient to use is needed.
Disclosure of Invention
The invention aims to provide an ultrahigh molecular solid slow-release disinfection bacteriostatic agent which contains a traditional Chinese medicine extract, has excellent tensile and impact resistance mechanical properties, can be used for continuously disinfecting and bacteriostasis for a long time, and solves the problems of short disinfection and bacteriostasis time and inconvenient transportation and use of liquid disinfection products;
in order to achieve the purpose, the technical scheme of the invention is as follows:
the invention relates to an ultrahigh molecular solid slow-release disinfection bacteriostatic agent, which comprises the following raw materials in percentage by weight: 30-60% of ultra-high molecular composite polyethylene material, 30-60% of volatile disinfection and bacteriostasis liquid, 10-30% of diluent and 1-10% of controlled release film. Wherein the ultra-high molecular composite polyethylene material is an adsorption and release carrier of the ultra-high molecular solid slow-release disinfection bacteriostat; the volatile disinfection bacteriostat is the disinfection and bacteriostasis active component in the ultra-high molecular solid slow-release bacteriostat; the diluent is used for diluting the volatile disinfection bacteriostat; the controlled release film assists the ultra-high molecular solid slow-release disinfection bacteriostat to play a slow-release role;
after the technical scheme is adopted, the ultrahigh molecular solid slow-release disinfection bacteriostatic agent has the following advantages: the ultrahigh molecular composite polyethylene material is used as an adsorption and release carrier, so that the diffusion of the sterilization bacteriostat is hindered due to larger steric hindrance, the release of the sterilization bacteriostat is greatly delayed, and the action time of the sterilization bacteriostat is prolonged; meanwhile, the ultrahigh molecular weight composite polyethylene material has excellent mechanical property, high hardness and good form and structure stability. The volatile disinfection bacteriostat liquid is used as the active component for disinfection and bacteriostasis, is easy to volatilize into the air and disperse to each corner, and achieves the omnibearing bacteriostasis effect on the space; the controlled release film can further carry out slow release on the sterilization bacteriostat, and further prolong the action time of the sterilization bacteriostat. The ultrahigh molecular solid slow-release bacteriostatic agent is a solid disinfection bacteriostatic agent, has higher long-acting disinfection bacteriostatic ability and good stability, can adapt to high-temperature hot and cold environments, is convenient to transport and store and is convenient to use;
the molecular weight of the ultrahigh molecular weight solid slow-release disinfection bacteriostat is 1500-2500 kDa, the tensile breaking stress is 20-40 Mpa, and the impact strength is 50-90 KJ/m2The density is 0.1-0.5 g/cm3The porosity is 40-70%;
the invention relates to an ultrahigh molecular solid sustained-release disinfection bacteriostat, the volatile disinfection bacteriostat contains the following raw materials by weight percent: 15.0 to 50.0 percent of traditional Chinese medicine extract, 1.0 to 5.0 percent of OE-10 polyoxyethylene oleyl alcohol ether, 1.0 to 5.0 percent of polyethylene glycol distearate, 0.5 to 1.5 percent of 4-propyl hydroxybenzoate and the balance of absolute ethyl alcohol. The traditional Chinese medicine extract is a disinfecting and bacteriostatic active component of the ultrahigh molecular solid sustained-release disinfecting bacteriostatic agent; OE-10 polyoxyethylene oleyl alcohol ether can increase solubility of Chinese medicinal extract, and enhance adsorption compatibility of carrier; the polyethylene glycol distearate can enhance the stability of the disinfection bacteriostat, increase the consistency of the disinfection bacteriostat and delay the volatilization and release of the disinfection bacteriostat; 4-propyl hydroxybenzoate is used as antioxidant to protect the antibacterial active ingredient from oxidation; absolute ethyl alcohol is used as a solvent;
the invention relates to an ultra-high molecular solid slow-release disinfection bacteriostat, wherein the diluent is an ethanol solution with the concentration of 50-75%;
the invention relates to an ultrahigh molecular solid slow-release disinfection bacteriostat, wherein a controlled-release film of the bacteriostat contains the following components in percentage by weight: 2.5 to 5.0 percent of N-vinyl pyrrolidone, 0.5 to 1.5 percent of 1,2, 3-glycerol triacetate, 1.0 to 2.5 percent of 1, 3-dihydroxy butane, 1.0 to 2.5 percent of C10 to 30 alkanol acrylate cross-linked polymer, and the balance of 50 to 90 percent of ethanol solution;
after the technical scheme is adopted, the ultrahigh molecular solid slow-release disinfection bacteriostatic agent has the following advantages: the ultrahigh molecular weight composite polyethylene material has excellent mechanical property, low cost and convenient production, and is beneficial to mass production; the traditional Chinese medicine extract in the volatile disinfection bacteriostat can be extracted from traditional Chinese medicines with disinfection bacteriostat, has the functions of killing and inhibiting various pathogenic bacteria and coronavirus, and has good disinfection and sterilization effects; meanwhile, the volatile disinfection bacteriostat liquid prepared by taking the traditional Chinese medicine extract as the main disinfection antibacterial component has no irritation to human skin and mucous membrane, no toxic or side effect and good safety. The controlled release film has a porous structure, has good gas permeability and stable property;
the preparation method of the ultrahigh molecular solid slow-release disinfection bacteriostat comprises the following steps:
(1) taking 15.0-50.0% of traditional Chinese medicine extract, adding 1.0-5.0% of OE-10 polyoxyethylene oleyl alcohol ether, 1.0-5.0% of polyethylene glycol distearate and 0.5-1.5% of 4-propyl hydroxybenzoate, and slowly dripping distilled water to 100% while stirring to obtain the volatile disinfection bacteriostat;
(2) taking 30-60% of volatile disinfection and bacteriostasis liquid, adding 50-75% of ethanol solution to 100%, and slowly stirring for 30-120min to be uniform to obtain diluted volatile disinfection and bacteriostasis liquid;
(3) taking an ultrahigh molecular composite polyethylene material, wherein the molecular weight is 1500-2500 kDa, the tensile breaking stress is 20-40 Mpa, and the impact strength is 50-90 KJ/m2The density is 0.1 to 0.5 g/cm3The porosity is 40% -70%, the ultra-high molecular weight composite polyethylene material is placed in a vacuum filtration bottle, the excessively diluted volatile disinfection bacteriostat is added until the material is completely immersed, the filtration is carried out under reduced pressure (0.01-0.05 MPa), the bacteriostat is completely saturated with the ultra-high molecular weight composite polyethylene material and then taken out, and the non-coated ultra-high molecular weight solid slow-release disinfection bacteriostat is obtained；
(4) Taking N-vinyl pyrrolidone and C10-30 alkanol acrylate cross-linked polymer, uniformly mixing according to the proportion of 2.5-5.0 percent and 1.0-2.5 percent, adding 30-60 percent of absolute ethyl alcohol to swell for 6-24 hours, adding 30-60 percent of distilled water after 6-24 hours, heating in a water bath at 50-70 ℃, uniformly stirring until the absolute ethyl alcohol is completely dissolved, adding 0.5-1.0 percent of 1,2, 3-glycerol triacetate and 1.0-2.5 percent of 1, 3-dihydroxy butane, and uniformly stirring to obtain a film forming agent;
(5) the film-forming agent is evenly sprayed on the surface of the non-coated ultrahigh molecular solid slow-release sterilization bacteriostat, and the solvent in the film-forming agent is naturally volatilized at normal temperature to obtain the ultrahigh molecular solid slow-release sterilization bacteriostat;
after the technical scheme is adopted, the preparation method of the ultrahigh molecular solid slow-release disinfection bacteriostat has the following advantages: the preparation method is simple to operate, and the prepared ultrahigh molecular solid slow-release sterilization bacteriostat has long-acting sterilization bacteriostasis capacity, is stable in release rate and is convenient for expanded production. The ultrahigh molecular solid slow-release disinfection bacteriostatic agent is convenient to use, avoids complicated and repeated disinfection operation, can achieve long-time disinfection and bacteriostatic effects, reduces the replacement times, and reduces the labor and raw material cost;
the ultrahigh molecular solid slow-release disinfection bacteriostat prepared according to the prescription and the preparation method of the invention has the advantages of long-acting disinfection bacteriostasis capacity, stable property, simple and convenient production and convenient use.
Drawings
FIG. 1 is a diagram of a real object of an ultra-high molecular solid sustained-release disinfection bacteriostatic agent;
FIG. 2 is a scanning electron microscope image of an ultra-high molecular weight polyethylene composite material with a molecular weight of 250 ten thousand;
FIG. 3 is a scanning electron microscope image of an ultra-high molecular weight polyethylene composite material with a molecular weight of 200 ten thousand;
FIG. 4 is a graph showing the release of the ultra-high molecular weight solid sustained-release sterilizing bacteriostatic agent prepared in example 1;
FIG. 5 is a graph showing the release of the ultra-high molecular weight solid sustained-release sterilizing bacteriostatic agent prepared in example 2;
FIG. 6 is the release curve of the ultra-high molecular weight solid sustained-release sterilization bacteriostat prepared in example 3.
Detailed Description
In order to further explain the technical scheme of the invention, the invention is explained in detail by the specific embodiment;
example 1
In this embodiment, the ultra-high molecular solid sustained-release sterilization bacteriostatic agent comprises the following raw materials by weight percent: 35% of ultra-high molecular composite polyethylene material, 45% of volatile disinfection and bacteriostasis liquid, 15% of diluent and 5% of controlled release film;
a preparation method of an ultrahigh molecular solid slow-release disinfection bacteriostatic agent comprises the following steps:
(1) taking 50.0% of the traditional Chinese medicine extract, adding 5.0% of OE-10 polyoxyethylene oleyl alcohol ether, 5.0% of polyethylene glycol distearate and 1.5% of 4-propyl hydroxybenzoate, and slowly dripping distilled water to 100% while stirring to obtain the volatile disinfection antibacterial liquid;
(2) taking 45% of volatile sterilization and bacteriostasis liquid, adding 75% of ethanol solution to 100%, and slowly stirring for 120min to be uniform, thus obtaining diluted volatile sterilization and bacteriostasis liquid;
(3) taking an ultra-high molecular weight composite polyethylene material, wherein the molecular weight is 2500 kDa, the tensile breaking stress is 40 Mpa, and the impact strength is 90 KJ/m2Density of 0.3 g/cm3Placing the ultrahigh molecular weight composite polyethylene material into a vacuum filtration bottle, adding the excessively diluted volatile sterilization bacteriostat until the ultrahigh molecular weight composite polyethylene material is completely immersed, and performing suction filtration under reduced pressure (0.05 MPa) to ensure that the sterilization bacteriostat completely saturates the ultrahigh molecular weight composite polyethylene material and then taking out the ultrahigh molecular weight composite polyethylene material, thereby obtaining the non-coated ultrahigh molecular weight solid slow-release sterilization bacteriostat;
(4) taking N-vinyl pyrrolidone and C10-30 alkanol acrylate cross-linked polymer, uniformly mixing according to the proportion of 4.0 percent and 2.5 percent, adding 50 percent of absolute ethyl alcohol for swelling for 24 hours, adding 40 percent of distilled water after 24 hours, heating in a water bath at 70 ℃, uniformly stirring until the absolute ethyl alcohol is completely dissolved, adding 1.0 percent of 1,2, 3-glycerol triacetate and 2.5 percent of 1, 3-dihydroxy butane, and uniformly stirring to obtain a film forming agent;
(5) the film-forming agent is evenly sprayed on the surface of the non-coated ultrahigh molecular solid slow-release sterilization bacteriostat, and the solvent in the film-forming agent is naturally volatilized at normal temperature to obtain the ultrahigh molecular solid slow-release sterilization bacteriostat;
the experimental performance of the ultrahigh molecular weight solid slow-release bacteriostatic agent prepared in example 1 is shown in tables 1 and 2, the mechanical properties of stretch resistance and impact resistance are excellent, the slow-release and bacteriostatic effects are excellent, the bacteriostatic duration reaches 23 days, the property is stable, and an ideal bacteriostatic effect can be achieved within a long time;
table 1 shows the performance and structure of the ultra-high molecular weight solid sustained-release sterilization bacteriostat prepared in example 1
| Item | Results |
| Tensile breaking stress of (Mpa) | 40.02±0.32 |
| The impact strength is (KJ/m)2） | 91.31±0.12 |
| Porosity (%) | 69.17±1.42 |
| Absorption capacity (g/cm) of medicinal liquid3） | 0.58±0.02 |
| Adsorption ratio (%) of chemical solution | 141.38±1.03 |
Table 2 shows the disinfection and bacteriostasis effects of the ultra-high molecular weight solid sustained-release bacteriostat prepared in example 1
Example 2
In this embodiment, the ultra-high molecular solid sustained-release sterilization bacteriostatic agent comprises the following raw materials by weight percent: 30% of ultra-high molecular composite polyethylene material, 40% of volatile disinfection and bacteriostasis liquid, 20% of diluent and 10% of controlled release film;
a preparation method of an ultrahigh molecular solid slow-release disinfection bacteriostatic agent comprises the following steps:
(1) taking 40.0% of traditional Chinese medicine natural extract, adding 3.0% of OE-10 polyoxyethylene oleyl alcohol ether, 3.0% of polyethylene glycol distearate and 1.0% of 4-propyl hydroxybenzoate, and slowly dripping distilled water to 100% while stirring to obtain volatile disinfection antibacterial liquid;
(2) taking 40% volatile disinfecting and bacteriostatic solution, adding 65% ethanol solution to 100%, and slowly stirring for 120min to obtain diluted volatile disinfecting and bacteriostatic solution;
(3) taking an ultra-high molecular weight composite polyethylene material, wherein the molecular weight of the ultra-high molecular weight composite polyethylene material is 2100 kDa, the tensile breaking stress is 30 Mpa, and the impact strength is 70 KJ/m2Density of 0.2 g/cm3The porosity is 60 percent, the ultrahigh molecular weight composite polyethylene material is placed in a vacuum filtration bottle, the excessively diluted volatile sterilization bacteriostat is added until the material is completely immersed, and the material is filtered under reduced pressure (0.05 MPa) to ensure that the bacteriostat completely saturates the ultrahigh molecular weight composite polyethylene material and then is taken out, thus obtaining the non-coated ultrahigh molecular weight solid slow-release sterilization bacteriostat;
(4) taking N-vinyl pyrrolidone and C10-30 alkanol acrylate cross-linked polymer, uniformly mixing according to the proportion of 3.0 percent and 2.0 percent, adding 50 percent of absolute ethyl alcohol for swelling for 24 hours, adding 42 percent of distilled water after 24 hours, heating in a water bath at 60 ℃, uniformly stirring until the absolute ethyl alcohol is completely dissolved, adding 1.0 percent of 1,2, 3-glycerol triacetate and 2.0 percent of 1, 3-dihydroxy butane, and uniformly stirring to obtain a film forming agent;
(5) the film-forming agent is evenly sprayed on the surface of the non-coated ultrahigh molecular solid slow-release disinfection bacteriostat, and the solvent in the film-forming agent is naturally volatilized at normal temperature, so that the ultrahigh molecular solid slow-release disinfection bacteriostat is obtained;
the performances of the ultrahigh molecular solid slow-release sterilization bacteriostat prepared by the embodiment 2 are shown in tables 3 and 4, the ultrahigh molecular solid slow-release sterilization bacteriostat has excellent mechanical properties, excellent slow-release and bacteriostasis effects, long bacteriostasis time of 21 days and stable properties, and can realize ideal bacteriostasis effect in a long time;
table 3 shows the performance and structure of the ultra-high molecular weight solid sustained-release bacteriostatic agent prepared in example 2
| Item | Results |
| Tensile breaking stress of (Mpa) | 29.22±0.21 |
| The impact strength is (KJ/m)2） | 70.11±0.23 |
| Porosity (%) | 61.24±0.76 |
| Absorption capacity (g/cm) of medicinal liquid3） | 0.55±0.12 |
| Adsorption ratio (%) of chemical solution | 121.14±0.56 |
Table 4 shows the bacteriostatic effect of the ultra-high molecular weight solid sustained-release bacteriostatic agent prepared in example 2
Example 3
In this embodiment, the ultra-high molecular solid sustained-release sterilization bacteriostatic agent comprises the following raw materials by weight percent: 30% of ultrahigh molecular weight composite polyethylene material, 30% of volatile disinfection and bacteriostasis liquid, 30% of diluent and 10% of controlled release film;
a preparation method of an ultrahigh molecular solid slow-release disinfection bacteriostatic agent comprises the following steps:
(1) taking a traditional Chinese medicine natural extract with the weight of 30.0%, adding 3.0% of OE-10 polyoxyethylene oleyl alcohol ether, 2.0% of polyethylene glycol distearate and 0.5% of 4-propyl hydroxybenzoate, and slowly dripping distilled water to 100% while stirring to obtain the volatile disinfection antibacterial liquid;
(2) taking 30% volatile sterilizing and bacteriostasis liquid, adding 50% ethanol solution to 100%, slowly stirring for 60min to obtain diluted volatile sterilizing and bacteriostasis liquid;
(3) taking an ultra-high molecular weight composite polyethylene material, wherein the molecular weight is 1800 kDa, the tensile breaking stress is 25 Mpa, and the impact strength is 60 KJ/m2Density of 0.5 g/cm3The porosity is 45 percent, the ultrahigh molecular weight composite polyethylene material is placed in a vacuum filtration bottle, the volatile disinfection bacteriostat liquid which is excessively diluted is added until the ultrahigh molecular weight composite polyethylene material is completely immersed, and the filtration is carried out under reduced pressure (0.03 MPa), so that the bacteriostat liquid is completely saturated with the ultrahigh molecular weight composite polyethylene material and then taken out, and the non-coated ultrahigh molecular weight solid slow-release disinfection bacteriostat is obtained;
(4) taking N-vinyl pyrrolidone and C10-30 alkanol acrylate cross-linked polymer, uniformly mixing according to the proportion of 2.5 percent and 1.0 percent, adding 45 percent of absolute ethyl alcohol to swell for 12 hours, adding 50 percent of distilled water after 12 hours, heating in a water bath at 50 ℃, uniformly stirring until the absolute ethyl alcohol is completely dissolved, adding 0.5 percent of 1,2, 3-glycerol triacetate and 1.0 percent of 1, 3-dihydroxy butane, and uniformly stirring to obtain a film-forming agent;
(5) the film-forming agent is evenly sprayed on the surface of the non-coated ultrahigh molecular solid slow-release disinfection bacteriostat, and the solvent in the film-forming agent is naturally volatilized at normal temperature, so that the ultrahigh molecular solid slow-release disinfection bacteriostat is obtained;
the performances of the ultrahigh molecular solid slow-release sterilization bacteriostat prepared by the embodiment 3 are shown in tables 5 and 6, the ultrahigh molecular solid slow-release sterilization bacteriostat has excellent mechanical properties, good slow-release and bacteriostasis effects, long bacteriostasis time of 17 days and stable properties, and can realize ideal bacteriostasis effect in a long time;
table 5 shows the performance and structure of the ultra-high molecular weight solid sustained-release bacteriostatic agent prepared in example 3
| Item | Results |
| Tensile breaking stress of (Mpa) | 25.46±0.11 |
| The impact strength is (KJ/m)2） | 60.11±0.64 |
| Porosity (%) | 46.11±0.91 |
| Absorption capacity (g/cm) of medicinal liquid3） | 0.49±0.15 |
| Adsorption ratio (%) of chemical solution | 97.76±0.93 |
Table 6 shows the bacteriostatic effect of the ultra-high molecular weight solid sustained-release bacteriostatic agent prepared in example 3
Claims (6)
1. The ultrahigh molecular solid slow-release disinfection bacteriostat is characterized by comprising the following raw materials in percentage by weight: 30-60% of ultra-high molecular composite polyethylene material, 30-60% of volatile disinfection and bacteriostasis liquid, 10-30% of diluent and 1-10% of controlled release film.
2. The ultra-high molecular solid slow-release disinfection bacteriostatic agent of claim 1, which is characterized in that: the molecular weight of the ultrahigh molecular composite polyethylene material is 1500-2500 kDa, the tensile breaking stress is 20-40 Mpa, and the impact strength is 50-90 KJ/m2The density is 0.1 to 0.5 g/cm3The porosity is 40% -70%.
3. The ultra-high molecular weight solid sustained-release sterilization bacteriostat of claim 1, wherein the volatile sterilization bacteriostat comprises the following components by weight percent: 15.0 to 50.0 percent of traditional Chinese medicine extract, 1.0 to 5.0 percent of OE-10 polyoxyethylene oleyl alcohol ether, 1.0 to 5.0 percent of polyethylene glycol distearate, 0.5 to 1.5 percent of 4-propyl hydroxybenzoate and the balance of distilled water.
4. The ultra-high molecular weight solid slow-release sterilization bacteriostat of claim 1, wherein the diluent is an ethanol solution with the concentration of 50-75%.
5. The ultra-high molecular solid slow-release sterilizing bacteriostatic agent as claimed in claim 1, wherein the controlled-release film comprises the following components by weight percent: 2.5 to 5.0 percent of N-vinyl pyrrolidone, 0.5 to 1.5 percent of 1,2, 3-glycerol triacetate, 1.0 to 2.5 percent of 1, 3-dihydroxy butane, 1.0 to 2.5 percent of C10 to 30 alkanol acrylate cross-linked polymer, and the balance of 50 to 90 percent of ethanol solution.
6. The method for preparing the ultra-high molecular solid slow-release disinfection bacteriostat according to claim 1, which is characterized by comprising the following steps:
(1) taking 15.0-50.0% of traditional Chinese medicine extract, adding 1.0-5.0% of OE-10 polyoxyethylene oleyl alcohol ether, 1.0-5.0% of polyethylene glycol distearate and 0.5-1.5% of 4-hydroxy propyl benzoate, and slowly dripping distilled water to 100% while stirring to obtain the volatile disinfection antibacterial liquid;
(2) taking 30-60% of volatile disinfection and bacteriostasis liquid, adding 50-75% of ethanol solution to 100%, and slowly stirring for 30-120min to be uniform to obtain diluted volatile disinfection and bacteriostasis liquid;
(3) taking an ultrahigh molecular composite polyethylene material, wherein the molecular weight is 1500-2500 kDa, the tensile breaking stress is 20-40 Mpa, and the impact strength is 50-90 KJ/m2The density is 0.1-0.5 g/cm3The porosity is 40% -70%; placing the ultrahigh molecular weight composite polyethylene material in a vacuum filtration bottle, adding the excessively diluted volatile sterilization bacteriostat until the ultrahigh molecular weight composite polyethylene material is completely immersed, performing suction filtration under reduced pressure (0.01-0.05 MPa) to ensure that the volatile sterilization bacteriostat completely saturates the ultrahigh molecular weight composite polyethylene material, and then taking out to obtain the non-coated ultrahigh molecular weight solid slow-release sterilization bacteriostat;
(4) taking N-vinyl pyrrolidone and C10-30 alkanol acrylate cross-linked polymer, uniformly mixing according to the proportion of 2.5-5.0 percent and 1.0-2.5 percent, adding 30-60 percent of absolute ethyl alcohol for swelling for 6-24h, then adding 30-60 percent of distilled water, heating in a water bath at 50-70 ℃, uniformly stirring until the absolute ethyl alcohol is completely dissolved, adding 0.5-1.0 percent of 1,2, 3-glycerol triacetate and 1.0-2.5 percent of 1, 3-dihydroxy butane, and uniformly stirring to obtain a film forming agent;
(5) and uniformly spraying the film-forming agent on the surface of the non-coated ultrahigh molecular solid slow-release sterilization bacteriostat, and naturally volatilizing the solvent in the film-forming agent at normal temperature to obtain the finished product of the ultrahigh molecular solid slow-release sterilization bacteriostat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011405292.9A CN112471145A (en) | 2020-12-04 | 2020-12-04 | Ultrahigh molecular solid slow-release disinfection bacteriostatic agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011405292.9A CN112471145A (en) | 2020-12-04 | 2020-12-04 | Ultrahigh molecular solid slow-release disinfection bacteriostatic agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112471145A true CN112471145A (en) | 2021-03-12 |
Family
ID=74938201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011405292.9A Pending CN112471145A (en) | 2020-12-04 | 2020-12-04 | Ultrahigh molecular solid slow-release disinfection bacteriostatic agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112471145A (en) |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1234414A (en) * | 1998-05-05 | 1999-11-10 | 罗姆和哈斯公司 | Polymer release-control composition |
| US6126931A (en) * | 1993-12-20 | 2000-10-03 | Surfacine Development Company, Llc | Contact-killing antimicrobial devices |
| CN1300541A (en) * | 1999-12-20 | 2001-06-27 | 西巴特殊化学品控股有限公司 | Biotic killing agent-polyester concentrate and biotic killing composition therefrom |
| CN1372935A (en) * | 2002-04-02 | 2002-10-09 | 广州贝氏药业有限公司 | Slowly released clamycin capsule |
| CN1418619A (en) * | 2001-11-14 | 2003-05-21 | 松下电器产业株式会社 | Slow released parts of volatile medicine and air conditioner using same |
| CN1479572A (en) * | 2000-12-03 | 2004-03-03 | ��̩�ռ����о��� | Barrier preventing wood pest access to wooden structures |
| CN103435424A (en) * | 2013-09-02 | 2013-12-11 | 济宁道淼新材料科技有限公司 | Controlled release coating material containing polymer micro nanoparticles |
| CN109769867A (en) * | 2018-09-21 | 2019-05-21 | 北京中捷四方生物科技股份有限公司 | A kind of Emerald ash borer imago attractant lure and preparation method thereof |
| CN110506740A (en) * | 2019-07-26 | 2019-11-29 | 中国农业大学 | A kind of antiscour, high pesticide microballoon withheld and preparation method thereof |
| US20200163329A1 (en) * | 2013-03-15 | 2020-05-28 | Ecolab Usa Inc. | Non-sorptive or minimally sorptive disinfectant wipes |
| CN111298177A (en) * | 2020-04-15 | 2020-06-19 | 广东爱锝医药技术研究院有限公司 | Chlorine dioxide slow-release bag |
| WO2020169828A1 (en) * | 2019-02-21 | 2020-08-27 | Universität Hamburg | Contact-active antibacterial polymeric materials |
| CN111802409A (en) * | 2020-06-23 | 2020-10-23 | 武汉理工大学 | Broad-spectrum antiviral antibacterial disinfectant and preparation method and application thereof |
| CN111849265A (en) * | 2020-06-18 | 2020-10-30 | 广州中医药大学(广州中医药研究院) | Water-absorbing controlled-release film for agilawood formation and agilawood production method |
-
2020
- 2020-12-04 CN CN202011405292.9A patent/CN112471145A/en active Pending
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6126931A (en) * | 1993-12-20 | 2000-10-03 | Surfacine Development Company, Llc | Contact-killing antimicrobial devices |
| CN1234414A (en) * | 1998-05-05 | 1999-11-10 | 罗姆和哈斯公司 | Polymer release-control composition |
| CN1300541A (en) * | 1999-12-20 | 2001-06-27 | 西巴特殊化学品控股有限公司 | Biotic killing agent-polyester concentrate and biotic killing composition therefrom |
| CN1479572A (en) * | 2000-12-03 | 2004-03-03 | ��̩�ռ����о��� | Barrier preventing wood pest access to wooden structures |
| CN1418619A (en) * | 2001-11-14 | 2003-05-21 | 松下电器产业株式会社 | Slow released parts of volatile medicine and air conditioner using same |
| CN1372935A (en) * | 2002-04-02 | 2002-10-09 | 广州贝氏药业有限公司 | Slowly released clamycin capsule |
| US20200163329A1 (en) * | 2013-03-15 | 2020-05-28 | Ecolab Usa Inc. | Non-sorptive or minimally sorptive disinfectant wipes |
| CN103435424A (en) * | 2013-09-02 | 2013-12-11 | 济宁道淼新材料科技有限公司 | Controlled release coating material containing polymer micro nanoparticles |
| CN109769867A (en) * | 2018-09-21 | 2019-05-21 | 北京中捷四方生物科技股份有限公司 | A kind of Emerald ash borer imago attractant lure and preparation method thereof |
| WO2020169828A1 (en) * | 2019-02-21 | 2020-08-27 | Universität Hamburg | Contact-active antibacterial polymeric materials |
| CN110506740A (en) * | 2019-07-26 | 2019-11-29 | 中国农业大学 | A kind of antiscour, high pesticide microballoon withheld and preparation method thereof |
| CN111298177A (en) * | 2020-04-15 | 2020-06-19 | 广东爱锝医药技术研究院有限公司 | Chlorine dioxide slow-release bag |
| CN111849265A (en) * | 2020-06-18 | 2020-10-30 | 广州中医药大学(广州中医药研究院) | Water-absorbing controlled-release film for agilawood formation and agilawood production method |
| CN111802409A (en) * | 2020-06-23 | 2020-10-23 | 武汉理工大学 | Broad-spectrum antiviral antibacterial disinfectant and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Fu et al. | A novel electrospun membrane based on moxifloxacin hydrochloride/poly (vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application | |
| Ye et al. | Development of gelatin/bacterial cellulose composite sponges as potential natural wound dressings | |
| Alven et al. | Polymer-based wound dressing materials loaded with bioactive agents: Potential materials for the treatment of diabetic wounds | |
| Soubhagya et al. | Preparation and characterization of chitosan/pectin/ZnO porous films for wound healing | |
| Ahmed et al. | In-vitro and in-vivo study of superabsorbent PVA/Starch/g-C3N4/Ag@ TiO2 NPs hydrogel membranes for wound dressing | |
| Li et al. | Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications | |
| Liu et al. | Antimicrobial electrospun nanofibers of cellulose acetate and polyester urethane composite for wound dressing | |
| Luo et al. | In situ fabrication of nano ZnO/BCM biocomposite based on MA modified bacterial cellulose membrane for antibacterial and wound healing | |
| Guang et al. | Chitosan/silk fibroin composite scaffolds for wound dressing | |
| Zorzi Bueno et al. | Development of porous lamellar chitosan‐alginate membranes: Effect of different surfactants on biomaterial properties | |
| Ahmady et al. | Fabrication of chitosan-gelatin films incorporated with thymol-loaded alginate microparticles for controlled drug delivery, antibacterial activity and wound healing: in-vitro and in-vivo studies | |
| Vidyalakshmi et al. | Studies on formulation and in vitro evaluation of PVA/chitosan blend films for drug delivery | |
| Rathore et al. | Fabrication of biomimetic porous novel sponge from gum kondagogu for wound dressing | |
| Helary et al. | Synthesis and in vivo integration of improved concentrated collagen hydrogels | |
| Singh | Gamma radiation synthesis and characterization of gentamicin loaded polysaccharide gum based hydrogel wound dressings | |
| Luneva et al. | Bilayer hydrogels for wound dressing and tissue engineering | |
| DE102018009814A1 (en) | Porous body made of dynamic biopolymer-based foams with a flexible pore size, process for its production and its applications | |
| Massey et al. | Preparation, characterization and biological evaluation of silver nanoparticles and drug loaded composites for wound dressings formed from Lallemantia royleana seeds’ mucilage | |
| Akşit et al. | Preparation of antibacterial electrospun poly (D, L-lactide-co-glycolide)/gelatin blend membranes containing Hypericum capitatum var. capitatum | |
| CN106359472A (en) | Bactericidal compound essential oil and preparation method of same | |
| CN110876814A (en) | Liquid band-aid rich in antibacterial peptide and preparation method thereof | |
| Castellano et al. | Chitosan–collagen electrospun nanofibers loaded with curcumin as wound-healing patches | |
| Abolhassani et al. | Antibacterial effect of electrospun polyurethane-gelatin loaded with honey and ZnO nanoparticles as potential wound dressing | |
| CN112471145A (en) | Ultrahigh molecular solid slow-release disinfection bacteriostatic agent and preparation method thereof | |
| Feng et al. | Design and characterization of plasticized bacterial cellulose/waterborne polyurethane composite with antibacterial function for nasal stenting |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20210312 |
|
| WD01 | Invention patent application deemed withdrawn after publication |