CN108078959A - A kind of antibacterial and protective film and its preparation method and application - Google Patents
A kind of antibacterial and protective film and its preparation method and application Download PDFInfo
- Publication number
- CN108078959A CN108078959A CN201611046107.5A CN201611046107A CN108078959A CN 108078959 A CN108078959 A CN 108078959A CN 201611046107 A CN201611046107 A CN 201611046107A CN 108078959 A CN108078959 A CN 108078959A
- Authority
- CN
- China
- Prior art keywords
- antibacterial
- protective film
- combination
- further preferably
- ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention provides a kind of antibacterial and protective film and its preparation method and application, each component and its content are in the antibacterial and protective film：5~90g/L of compound ion anti-biotic material, 5~90g/L of film forming agent, 5~90g/L of thickener, 5~90g/L of moisturizer, 1~5g/L of nano silver, 1~10g/L of plant extract agent, 1~10g/L of 1~10g/L of preservative, 1~10g/L of solubilizer and freshener, surplus is water.The antibacterial and protective film can be sprayed at human skin surface's (especially hand and facial skin) and form protection film, its contact with the human skin is good, while good moistening effect is kept, there is lasting antibiotic and sterilizing effect again, there is stronger bactericidal effect to methicillin-resistant staphylococcus aureus (superbacteria represents bacterium), Escherichia coli, Legionella, pyococcus, hepatitis virus and Candida albicans and all kinds of epidemic infectious diseases and bacterial spore etc..
Description
Technical field
The invention belongs to medical preparation field, be related to a kind of antibacterial and protective film and its preparation method and application more particularly to
A kind of antibacterial and protective film for being sprayed at human skin surface and its preparation method and application.
Background technology
In recent years, due to the abuse of antibiotic, the appearance of superbacteria is caused, at present MRSA (methicillin-resistant staphylococcus
Staphylococcus) become one of highest inside-hospital infection pathogen of global incidence, MRSA infection is listed in the world 3 and is most difficult to greatly
The infectious diseases (MRSA, hepatitis B, HIV infection) of solution is the first.
Bacterial resistance sex chromosome mosaicism is very serious.In developed country, the inpatient for having 5%~10% every year occurred
One or more infection.The patient that hospital infection occurs every year for the U.S. is about 2,000,000, dead 90000 people, and economic loss is up to 45
Hundred million~5,700,000,000 dollars.In developing country, the danger of hospital infection, which occurs, will be higher by 2 times~20 times of developed country.Chinese Hospitals
Infection rate is 6% or so, but rate of failing to report is very high, up to more than 50%.The U.S. in 2007《American Journal of Medicine》Weekly
1 part of government's survey report of publication is said, annual to be expected to have more than 90,000 people's severe infections MRSA.Dutch National Public Health and environment
Pointed by research, the whole world may have up to 53,000,000 people to carry fatal superbug MRSA.2010, statistics display was printing
Degree and Pakistan confirm the case for infecting " superbacteria " up to 150, and Britain also has 70, in addition European Austria,
Belgium, Germany, Holland, Norway, Sweden and France, the Canada and the U.S. of North America, African Kenya, Asia Japan and
There are confirmation case in varying numbers in the states such as Singapore.According to incompletely statistics, Japan, Brazil and Britain respectively because it lethal 27
People, 18 people, 5 people.On October 26th, 2010, Chinese Center for Disease Control and Prevention circulated a notice of the super antibiotic resistant bacterial pathogens disease of three infection
Example, wherein dead 1.CHINET (Chinese bacterial drug resistance monitoring) investigation to domestic 18 large hospitals in 2014, it is super
The first six digits that bacterium firmly infects in occupation of clinical bacteria, and the drug resistance of bacterium goes up year by year, highest is up to more than 80%.
In April, 2015, British government was newest《National emergency management risk inventory》It is pointed out in report, since doctor uses antibiotic not
When, in fact it could happen that a variety of " superbacterias " to develop immunity to drugs to antibiotic.Once locality outburst is related to " super thin on a large scale
The blood infection event of bacterium ", it will have 200,000 people impacted, have about 80,000 people " may be dead " in the middle.In May, 2016,
A authoritative research report of Britain is pointed out, if the problems such as countries in the world are not with regard to abuse of antibiotics is promptly taken action, to 2050
Year, so-called " superbacteria " will cause a patient death in every three seconds.In July, 2016, tool《The Beijing News》Report, in Brazilian
About Federal University microorganism institute issues a report and claims recently, and scientific research personnel has found after sampling detection in 1 year, inner
At Yue Reneilu 5 there is " superbacteria " in the waters at seabeach, and this kind of bacterium can trigger a variety of diseases, the people of particularly immune force difference
Group is easily infected, this has undoubtedly coverd with one layer of shade to the Rio Olympic Games that will be held.In July, 2016, the U.S. are found
Second case carries " superbacteria " case of the CR-1 containing gene M, this gene can make bacterium " last to being referred to as in antibiotic
The polymyxins in one of defence line " generates drug resistance.These soul-stirring message one by one, even more allow people to ecological environment and
The danger that the deterioration of microbial environment is brought to the earth and human health is worried.
Hand and face are that people are easiest to contact stain source in daily life and work (including bacterium and virus etc.)
Exposure portion, many diseases are all to be transmitted to human body by hand, face.Diligent wash up be good habits and customs and
Precautionary measures, but be unpractical in a manner that frequent wash up reduces and infects disease.For example, it is anti-superbacteria
The infection of MRSA has expert once to suggest that people every two hours washed a hand, is washed till every time 2 minutes less, also to clean, wash step by step
The complete palm of the hand is washed one's hands the back of the body, and finger front and side are washed in place, are then dried with face tissue, then with the face-cloth paper washer finger tight fire hose
Head.So complicated program is difficult to realize in people normally work and live.
At present, go out (such as to take high ferro, aircraft, steamer, subway or automobile when crowd is in public place and go to cure
Institute's medical treatment etc., hand is inevitably contacted with the external world, but these places are exactly the ground of superbacteria growth.
Superbacteria can shift in the mankind, animal and environment, and current animal abuse of antibiotics situation is infected with people
Drug-fast bacteria contact is close, the infecting both domestic animals and human pathogenetic bacteria particularly with drug resistance, can be through overfeeding after food-borne zoogenetic infection
Object chain or skin contact infection give people, and the meat containing drug tolerant bacteria or antibiotic residue, which is eaten for a long time, can increase people's Endophytic bacteria
Drug resistance.
Since " superbacteria " is difficult to treat, it is defence to tackle its best approach.From it is currently understood that mesh in world wide
It is preceding without basic effectively preventing means, cannot prevent between person to person, object and object, people and object, people and birds livestock by washing one's hands
Cross infection and direct contagion.
CN 103784360A disclose a kind of handguard film and preparation method thereof, contain by weight in the handguard film：It is living
The grease proofing component 5~20% of property, moisturizer 11~30%, tea leaf powder 3~12%, vitamin 1~5%, water complement to 100%.Institute
It is one or both of hydroxypropyl cellulose, hydroxyethyl cellulose to state the grease proofing component of activity；The moisturizer is urea, the third two
One or more in alcohol, glycerine, honey, moisturizing factor or amino acid；The tea leaf powder is green tea powder or smears tea.The hand film
Mainly play nursing and maintenance, protection and bactericidal effect well can not be played to hand.
Therefore, how to face hand effectively protect and can be carried out at the same time bactericidal is urgent need to resolve one
A problem.
The content of the invention
For the degerming cleaning process that human skin in the prior art especially hand and facial skin clean compared with
To be cumbersome, and existing hand film or face film etc. mainly play a part of to nurse and maintain, and good protection can not be played to hand
And the problems such as bactericidal effect, the present invention provides a kind of antibacterial and protective films and its preparation method and application.The antibacterial and protective film
Human skin surface's (especially hand and facial skin) can be sprayed at and form protection film, contact with the human skin
It is good, and then play lasting antibiotic and sterilizing, protection and the effect of moisturizing.
Antibacterial protecting film of the present invention can kill methicillin-resistant staphylococcus aureus (MRSA), Escherichia coli,
Legionella, pyococcus, hepatitis virus, Candida albicans, staphylococcus aureus, all kinds of epidemic infection germs and bacterium
Gemma etc., sterilizing rate are without any side effects to human body more than 99%.When being primarily adapted for use in outgoing crowd and being in public place
(as taken high ferro, aircraft, steamer, subway and automobile；And hospital's medical treatment, conference centre and large-scale recreation facility place etc.) hand
Portion isolates with contactant, for disaster area and epidemic-stricken area disinfection protection.It lives outdoors suitable for infant and students in middle and primary schools etc. simultaneously
The protection of hand, prevents the cross infection of person to person, people and object and object and object when dynamic.
For this purpose, the present invention uses following technical scheme：
In a first aspect, the present invention provides a kind of antibacterial and protective film, the antibacterial and protective film is used for the shape on human skin
Into protective film, each component and its content are in the antibacterial and protective film：
Wherein, the content of compound ion anti-biotic material can be 5g/L, 10g/L, 20g/L, 30g/L, 40g/L, 50g/L,
60g/L, 70g/L, 80g/L or 90g/L etc., it is not limited to cited numerical value, other interior numerical value of listed scope are feasible；
The content of the film forming agent can be 5g/L, 10g/L, 20g/L, 30g/L, 40g/L, 50g/L, 60g/L, 70g/L, 80g/L or
90g/L etc., it is not limited to cited numerical value, other interior numerical value of listed scope are feasible；The content of the thickener can
For 5g/L, 10g/L, 20g/L, 30g/L, 40g/L, 50g/L, 60g/L, 70g/L, 80g/L or 90g/L etc., it is not limited to
Cited numerical value, other interior numerical value of listed scope are feasible；The content of the moisturizer can be 5g/L, 10g/L, 20g/L,
30g/L, 40g/L, 50g/L, 60g/L, 70g/L, 80g/L or 90g/L etc., it is not limited to cited numerical value, listed model
Other numerical value are feasible in enclosing；The content of the nano silver can 1g/L, 2g/L, 3g/L, 4g/L or 5g/L etc., it is not limited to
Cited numerical value, other interior numerical value of listed scope are feasible；The content of the plant extract agent can be 1g/L, 2g/L, 3g/L,
4g/L, 5g/L, 6g/L, 7g/L, 8g/L, 9g/L or 10g/L etc., it is not limited to cited numerical value, in listed scope its
His numerical value is feasible；The content of the preservative can be 1g/L, 2g/L, 3g/L, 4g/L, 5g/L, 6g/L, 7g/L, 8g/L, 9g/L
Or 10g/L etc., it is not limited to cited numerical value, other interior numerical value of listed scope are feasible；The content of solubilizer can be
1g/L, 2g/L, 3g/L, 4g/L, 5g/L, 6g/L, 7g/L, 8g/L, 9g/L or 10g/L etc., it is not limited to cited number
Value, other interior numerical value of listed scope are feasible；The content of freshener can be 1g/L, 2g/L, 3g/L, 4g/L, 5g/L, 6g/L, 7g/
L, 8g/L, 9g/L or 10g/L etc., it is not limited to cited numerical value, other interior numerical value of listed scope are feasible.
In the present invention, the antibacterial and protective film can shape after being sprayed at human skin surface's (especially hand and facial skin)
Into protection film, play the role of lasting antibiotic and sterilizing, protection and moisturizing.It utilizes compound ion anti-biotic material and nano silver
Synergistic effect be obviously improved the bactericidal effect of the antibacterial and protective film, if the content of nano silver is more than the 1~5g/L,
The bactericidal effect of antimicrobial spray is unable to reach level of the present invention.
Below as currently preferred technical solution, but not as the limitation of technical solution provided by the invention, pass through
Following technical scheme can preferably reach and realize the technical purpose and advantageous effect of the present invention.
As currently preferred technical solution, each component and its content are in the antibacterial and protective film：
Preferably, each component and its content are in the antibacterial and protective film：
As currently preferred technical solution, the compound ion anti-biotic material is by ionic liquid and inorganic nano stratification
The progress intercalation assembling of object alpha-phosphate hydrogen zirconium is closed to be prepared.The preparation method of the compound ion anti-biotic material is CN
Preparation method described in 102113484A under normal pressure mixes ionic liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
It closes stirring and ion-exchange reactions occurs, be then centrifuged for separating, wash, be dried to obtain compound ion anti-biotic material.
Preferably, the ionic liquid be imidazole ion liquid and/or pyridine ion liquid, further preferably pyridine from
Sub- liquid；In the present invention, the compound ion that is prepared with pyridine ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
The effect that the synergistic effect of anti-biotic material and nano silver reaches is best.
Preferably, the molar ratio of the ionic liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium is 1:(4~8), example
Such as 1:4、1:5、1:6、1:7 or 1:8 etc., it is not limited to cited numerical value, other interior numerical value of listed scope are feasible, into
One step is preferably 1:5.The molar ratio of experiment proof ionic liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium is within this range
Can compound ion anti-biotic material be made there is more excellent anti-microbial property.
As currently preferred technical solution, the film forming agent is polyvinyl alcohol, 2,2,4- trimethyl -1,3- pentanediols
Any one in mono isobutyrate, propandiol butyl ether, propylene glycol methyl ether acetate, diacetone alcohol or dimethyl ether or extremely
Combination two kinds few, the combination is typical but non-limiting examples have：Polyvinyl alcohol and 2,2,4- trimethyl -1,3- pentanediol lists
The combination of the combination of isobutyrate, propandiol butyl ether and propylene glycol methyl ether acetate, diacetone alcohol and dimethyl ether
Combination, polyvinyl alcohol, 2, the combination of 2,4- trimethyl -1,3- pentanediol mono isobutyrates and propandiol butyl ether, polyvinyl alcohol, 2,
2,4- trimethyl -1,3- pentanediol mono isobutyrates, propandiol butyl ether, propylene glycol methyl ether acetate, diacetone alcohol and dipropyl two
Combination of diethylene glycol dimethyl ether etc., further preferably polyvinyl alcohol.
As currently preferred technical solution, the thickener is sodium carboxymethylcellulose, propylene glycol alginate, card
Any one in ripple nurse, starch phosphate sodium, chitin, tamarind gum or hydroxypropyl starch ether or at least two combination, institute
It states combination typical case but non-limiting examples has：The combination of sodium carboxymethylcellulose and propylene glycol alginate, carbomer, starch phosphorus
The combination of acid esters sodium and chitin, the combination of chitin, tamarind gum and hydroxypropyl starch ether, sodium carboxymethylcellulose, seaweed
The combination of acid propylene glycol ester, carbomer, starch phosphate sodium and chitin, carbomer, starch phosphate sodium, chitin, Luo Wang
The combination of sub- glue and hydroxypropyl starch ether, sodium carboxymethylcellulose, propylene glycol alginate, carbomer, starch phosphate sodium, first
Combination of shell element, tamarind gum and hydroxypropyl starch ether etc., further preferably propylene glycol alginate.
As currently preferred technical solution, the moisturizer is glycerine, propylene glycol, aloe water, vitamin E, poly-
Any one in ethylene glycol or D-sorbite or at least two combination, the combination is typical but non-limiting examples have：The third three
The combination of the combination of the combination of alcohol and propylene glycol, aloe water and vitamin E, polyethylene glycol and D-sorbite, glycerine, propylene glycol
With the combination of aloe water, the combination of vitamin E, polyethylene glycol and D-sorbite, glycerine, propylene glycol, aloe water, vitamin E,
Combination of polyethylene glycol and D-sorbite etc., further preferably glycerine.
As currently preferred technical solution, the plant extract agent is grape seed extract, cherry extract, aloe
Any one in extract, ginkgo biloba p.e, Lotus Plumule P.E. or wolfberry fruit extract or at least two combination, the combination
Typical but non-limiting examples have：The combination of grape seed extract and cherry extract, cherry extract and aloe extract
Combination, the combination of aloe extract, ginkgo biloba p.e and Lotus Plumule P.E., aloe extract, ginkgo biloba p.e, lotus seeds
The combination of heart extract and wolfberry fruit extract, grape seed extract, cherry extract, aloe extract, ginkgo biloba p.e, lotus
Combination of sub- heart extract and wolfberry fruit extract etc., further preferably grape seed extract.
Preferably, the preservative is imidazolidinyl urea, interior uride, isothiazolinone, p-hydroxybenzoate, benzene first
Any one in acid or potassium sorbate or at least two combination, the combination is typical but non-limiting examples have：Imidazolidinyl
Urea and the combination of interior uride, the combination of isothiazolinone and p-hydroxybenzoate, the combination of benzoic acid and potassium sorbate, miaow
The combination of oxazolidinyl urea, interior uride and isothiazolinone, isothiazolinone, p-hydroxybenzoate, benzoic acid and sorbic acid
The combination of potassium, the combination of imidazolidinyl urea, interior uride, isothiazolinone, p-hydroxybenzoate, benzoic acid and potassium sorbate
Deng, further preferably imidazolidinyl urea.
Preferably, the solubilizer is polyoxyethylene hardened castor oil, Emulsifier EL-60, aliphatic alcohol polyethenoxy
It is arbitrary in ether, aliphatic alcohol polyethenoxy-polyethenoxy ether, polyoxyethylene sorbitan fatty acid ester or polyglyceryl fatty acid ester
It is a kind of or at least two combination, it is described combination typical case but non-limiting examples have：Polyoxyethylene hardened castor oil and polyoxy second
The combination of alkene castor oil, the combination of fatty alcohol polyoxyethylene ether and aliphatic alcohol polyethenoxy-polyethenoxy ether, polyoxyethylene sorbitan
The combination of Span and polyglyceryl fatty acid ester, polyoxyethylene hardened castor oil, Emulsifier EL-60 and fat
The combination of alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, aliphatic alcohol polyethenoxy-polyethenoxy ether and polyoxyethylene sorbitan mountain
The combination of pears alcohol fatty acid ester, polyoxyethylene hardened castor oil, Emulsifier EL-60, fatty alcohol polyoxyethylene ether, fatty alcohol
Combination of polyoxyethylene polyoxypropylene ether, polyoxyethylene sorbitan fatty acid ester and polyglyceryl fatty acid ester etc., further
Preferably fatty alcohol polyoxyethylene ether.
Preferably, the freshener is menthol, menthyl lactate, amide of mint, menthyl succinate, N- ethyls-right
Any one in menthyl -3- formamides or 2-Isopropyl-N,2,3-trimethylbutyramide or at least two combination, described group
It closes typical case but non-limiting examples has：The combination of the combination of menthol and menthyl lactate, amide of mint and menthyl succinate,
The combination of N- ethyls-to menthyl -3- formamides and 2-Isopropyl-N,2,3-trimethylbutyramide, menthol, lactic acid peppermint
The combination of ester, amide of mint and menthyl succinate, menthyl succinate, N- ethyls-to menthyl -3- formamides and 2- isopropyls
Base-N, the combination of 2,3- trimethylbutyramides, menthol, menthyl lactate, amide of mint, menthyl succinate, N- ethyls-right
Combination of menthyl -3- formamides and 2-Isopropyl-N,2,3-trimethylbutyramide etc., further preferably amide of mint.
As currently preferred technical solution, each component and its content are in the antibacterial and protective film：
Wherein, compound ion anti-biotic material is inserted by pyridine ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
Layer assembling is prepared.
In the present invention, the bactericidal effect of obtained antibacterial and protective film and the protection of formation are prepared with above-mentioned each substance and proportioning
Film it is optimal into film persistence.
Second aspect, the present invention provides the preparation method of above-mentioned antibacterial and protective film, the antibacterial and protective film is by with lower section
Method is prepared：
By the compound ion anti-biotic material of formula ratio, film forming agent, thickener, moisturizer, nano silver, plant extract agent, anti-
Rotten agent, solubilizer, freshener and water are added in container, are uniformly mixed, in 60~80 DEG C (such as 60 DEG C, 63 DEG C, 65 DEG C,
67 DEG C, 70 DEG C, 73 DEG C, 75 DEG C, 77 DEG C or 80 DEG C etc., it is not limited to cited numerical value, other interior numerical value of listed scope
It is feasible.) heat preservation 1~3h (such as 1h, 1.5h, 2h, 2.5h or 3h etc., it is not limited to cited numerical value, listed scope
Other interior numerical value are feasible.), then heat to 120~150 DEG C (such as 120 DEG C, 125,130 DEG C, 135 DEG C, 140 DEG C, 145 DEG C
Or 150 DEG C etc., it is not limited to cited numerical value, other interior numerical value of listed scope are feasible.) 2~5h of heat preservation (such as
2h, 2.5h, 3h, 3.5h, 4h, 4.5h or 5h etc., it is not limited to cited numerical value, other interior numerical value of listed scope
Row.), antimicrobial spray is made in natural cooling.
The third aspect, the present invention provides the purposes of above-mentioned antibacterial and protective film, and antibacterial and protective film is sprayed at human skin
On；
Preferably, antibacterial and protective film is sprayed on hand and/or facial skin.
Compared with prior art, the invention has the advantages that：
(1) antibacterial and protective film of the present invention is sprayable in human skin surface and forms protection film, plays and continues
The effect of antibacterial bacteriostatic；The present invention makes it have good kill using the synergistic effect of compound ion anti-biotic material and nano silver
Bacterium effect can kill methicillin-resistant staphylococcus aureus (superbacteria represents bacterium), Escherichia coli, Legionella, suppurative
Coccus, hepatitis virus, Candida albicans, all kinds of epidemic infectious diseases and bacterial spore etc., sterilizing rate is more than 98%.
(2) antibacterial and protective film of the present invention in the protection film that human skin surface is formed there is preferable film forming to hold
Long property, persistence is up to for 24 hours.It is particularly suitable for being used for when people (can be suitable for infant and students in middle and primary schools simultaneously) are outgoing
The protection of hand face and isolate with contactant, while suitable for the disinfection protection in disaster area and epidemic-stricken area, prevent person to person, people
With the cross infection of object and object and object.
(3) the compound ion anti-biotic material in antibacterial and protective film of the present invention is a kind of cheap, environmental-friendly
The compatibility of anti-biotic material and organic material is good；And the antibacterial and protective film is free of toxic component, and it is non-corrosive, to human body skin
Skin is without any stimulation.
Specific embodiment
For the present invention is better described, technical scheme is readily appreciated, below to the present invention further specifically
It is bright.But following embodiments is only the simple example of the present invention, does not represent or limit the scope of the present invention, this
Invention protection domain is subject to claims.
Embodiment 1：
A kind of antibacterial and protective film is present embodiments provided, contains following components in every liter of antibacterial and protective film：Compound ion resists
Bacterium material 45g, film forming agent polyvinyl alcohol 50g, thickener propylene glycol alginate 50g, moisturizer glycerine 50g, nano silver 3g,
Plant extracts grape seed extract 5g, preservative imidazolidinyl urea 5g, solubilizer fatty alcohol polyoxyethylene ether 5g and freshener
Amide of mint 5g, surplus are water.
Wherein, compound ion anti-biotic material is carried out using pyridine ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
Intercalation assembling is prepared, and the molar ratio of pyridine ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium is 1:5.
Embodiment 2：
A kind of antibacterial and protective film is present embodiments provided, contains following components in every liter of antibacterial and protective film：Compound ion resists
Bacterium material 20 g, film forming agent 2,2,4- trimethyl -1,3- pentanediol mono isobutyrates 70g, thickener propylene glycol alginate 40g,
Moisturizer is propylene glycol 15g, nano silver 2g, plant extracts grape seed extract 6g, preservative imidazolidinyl urea 8g, solubilizer
Polyoxyethylene hardened castor oil 3g and freshener n-ethyl-p-menthane-3 alcohol 2g, surplus are pure water.
Wherein, compound ion anti-biotic material is carried out using imidazole ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
Intercalation assembling is prepared, and the molar ratio of imidazole ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium is 1:4.
Embodiment 3：
A kind of antibacterial and protective film is present embodiments provided, contains following components in every liter of antibacterial and protective film：Compound ion resists
Bacterium material 10g, film forming agent polyvinyl alcohol 50g, thickener sodium carboxymethylcellulose 20g, moisturizer glycerine 10g, nano silver 4g,
Plant extracts aloe extract 4g, preservative interior uride 6g, solubilizer fatty alcohol polyoxyethylene ether 5g and freshener lactic acid
Menthyl ester 4g, surplus are pure water.
Wherein, compound ion anti-biotic material is carried out using pyridine ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
Intercalation assembling is prepared, and the molar ratio of pyridine ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium is 1:8.
Embodiment 4：
A kind of antibacterial and protective film is present embodiments provided, contains following components in every liter of antibacterial and protective film：Compound ion resists
Bacterium material 40g, film forming agent propandiol butyl ether 30g, thickener carbomer 60g, moisturizer are aloe water 5g, nano silver 1g, plant
Extract cherry extract 3g, preservative p-hydroxybenzoate 5g, solubilizer aliphatic alcohol polyethenoxy-polyethenoxy ether 8g and
Freshener menthyl succinate 6g, surplus are pure water.
The preparation method and materials of the compound ion anti-biotic material are in the same manner as in Example 1.
Embodiment 5：
A kind of antibacterial and protective film is present embodiments provided, contains following components in every liter of antibacterial and protective film：Compound ion resists
Bacterium material 15g, film forming agent propylene glycol methyl ether acetate 20g, thickener chitin 50g, moisturizer vitamin E2 0g, nano silver
5g, plant extracts ginkgo biloba p.e 2g, preservative isothiazolinone 7g, solubilizer fatty alcohol polyoxyethylene ether 6g and refrigerant
Agent amide of mint 3g, surplus are pure water.
The preparation method and materials of the compound ion anti-biotic material are in the same manner as in Example 1.
Embodiment 6：
A kind of antibacterial and protective film is present embodiments provided, contains following components in every liter of antibacterial and protective film：Compound ion resists
Bacterium material 30g, film forming agent diacetone alcohol 60g, thickener hydroxypropyl starch ether 70g, moisturizer are polyethylene glycol 60g, nano silver
3g, plant extracts Lotus Plumule P.E. 7g, preservative benzoic acid 3g, solubilizer polyoxyethylene sorbitan fatty acid ester 7g
With freshener N- ethyls-to menthyl -3- formamide 7g, surplus is pure water.
The preparation method and materials of the compound ion anti-biotic material are in the same manner as in Example 1.
Embodiment 7：
A kind of antibacterial and protective film is present embodiments provided, contains following components in every liter of antibacterial and protective film：Compound ion resists
Bacterium material 5g, film forming agent dimethyl ether 40g, thickener tamarind gum 80g, moisturizer D-sorbite 23g, nano silver
3g, plant extracts wolfberry fruit extract 5g, potassium sorbate preservative 4g, solubilizer polyglyceryl fatty acid ester 4g and freshener 2- are different
Propyl-N, 2,3- trimethylbutyramide 8g, surplus is pure water.
The preparation method and materials of the compound ion anti-biotic material are in the same manner as in Example 1.
Embodiment 8：
A kind of antibacterial and protective film is present embodiments provided, contains following components in every liter of antibacterial and protective film：Compound ion resists
Bacterium material 60g, film forming agent dimethyl ether 40g, thickener tamarind gum 80g, moisturizer D-sorbite 40g, nano silver
3g, plant extracts wolfberry fruit extract 5g, potassium sorbate preservative 4g, solubilizer polyglyceryl fatty acid ester 4g and freshener 2- are different
Propyl-N, 2,3- trimethylbutyramide 8g, surplus is pure water.
The preparation method and materials of the compound ion anti-biotic material are in the same manner as in Example 1.
Embodiment 9：
The preparation method of antibacterial protecting film in above-described embodiment 1-8 is present embodiments provided, the method is as follows：
By the compound ion anti-biotic material of formula ratio, film forming agent, thickener, moisturizer, nano silver, plant extract agent, anti-
Rotten agent, solubilizer, freshener and water are added in container, are uniformly mixed, and are kept the temperature 2h in 70 DEG C, are then heated to 130 DEG C of guarantors
Antibacterial and protective film is made in warm 3h, natural cooling.
Embodiment 10：
Except keeping the temperature 3h in 60 DEG C, then heat to outside 120 DEG C of heat preservation 5h, unclassified stores dosage and preparation process with reality
It applies identical in example 9.
Embodiment 11：
Except keeping the temperature 2h in 80 DEG C, then heat to outside 150 DEG C of heat preservation 2h, unclassified stores dosage and preparation process with reality
It applies identical in example 9.
Embodiment 12：
The purposes of antibacterial protecting film in above-described embodiment 1-8 is present embodiments provided, antibacterial and protective film is sprayed at hand
And face.
Comparative example 1：
This comparative example provides a kind of antibacterial and protective film, forms in addition to being free of nano silver, other composition contents with
It is identical in embodiment 1.
Comparative example 2：
This comparative example provides a kind of antibacterial and protective film, forms in addition to being free of compound ion anti-biotic material, other groups
It is in the same manner as in Example 1 into content.
Antimicrobial spray in above-described embodiment 1-8 and comparative example 1-2 is tested for the property, tests it to superbacteria
The bactericidal effect of methicillin-resistant staphylococcus aureus (MRSA), through Guangdong Province's microbiological analysis Spot detection, testability
The results are shown in Table 1 for energy.
Table 1：Antimicrobial spray performance test table in embodiment 1-8 and comparative example 1-2
The result of integrated embodiment 1-8 and comparative example 1-2 can be seen that antibacterial and protective film of the present invention it is sprayable in
Human skin surface simultaneously forms protection film, plays the antibacterial effect of sustained anti-microbial；The present invention utilizes compound ion anti-biotic material
With the synergistic effect of nano silver, good bactericidal effect is made it have, it is (super methicillin-resistant staphylococcus aureus can be killed
Bacterium represents bacterium), Escherichia coli, Legionella, pyococcus, hepatitis virus, Candida albicans, all kinds of epidemic infectious diseases and
Bacterial spore etc., sterilizing rate is more than 98%.Antibacterial and protective film of the present invention is thin in the protection that human skin surface is formed
Film has preferably into film persistence, and persistence is up to for 24 hours.Be particularly suitable for people (can simultaneously be suitable for infant and
Students in middle and primary schools) it is outgoing when isolate for the protection of hand face and with contactant, while disappearing suitable for disaster area and epidemic-stricken area
Poison protection, prevents the cross infection of person to person, people and object and object and object.Meanwhile answering in antibacterial and protective film of the present invention
Close ion antibacterial material be a kind of cheap, environmental-friendly anti-biotic material and organic material compatibility it is good；It is and described anti-
Bacterium protecting film is free of toxic component, non-corrosive, to human skin without any stimulation.
Applicant states that the present invention illustrates the method detailed of the present invention, but not office of the invention by above-described embodiment
It is limited to above-mentioned method detailed, that is, does not mean that the present invention has to rely on above-mentioned method detailed and could implement.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., all fall within protection scope of the present invention and the open scope.
Claims (10)
1. a kind of antibacterial and protective film, which is characterized in that the antibacterial and protective film is described for forming protective film on human skin
Each component and its content are in antibacterial and protective film：
2. antibacterial and protective film according to claim 1, which is characterized in that each component and its content in the antibacterial and protective film
For：
Preferably, each component and its content are in the antibacterial and protective film：
3. antibacterial and protective film according to claim 1 or 2, which is characterized in that the compound ion anti-biotic material is by ion
Liquid carries out intercalation assembling with inorganic nano layer compound alpha-phosphate hydrogen zirconium and is prepared；
Preferably, the ionic liquid is imidazole ion liquid and/or pyridine ion liquid, further preferably pyridinium ion liquid
Body；
Preferably, the molar ratio of the ionic liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium is 1:(4~8), further
Preferably 1:5.
4. according to claim 1-3 any one of them antibacterial and protective films, which is characterized in that the film forming agent for polyvinyl alcohol,
2,2,4- trimethyl -1,3- pentanediol mono isobutyrates, propandiol butyl ether, propylene glycol methyl ether acetate, diacetone alcohol or dipropyl
Any one in glycol dimethyl ether or at least two combination, further preferably polyvinyl alcohol.
5. according to claim 1-4 any one of them antibacterial and protective films, which is characterized in that the thickener is carboxymethyl cellulose
It is any one in plain sodium, propylene glycol alginate, carbomer, starch phosphate sodium, chitin, tamarind gum or hydroxypropyl starch ether
Kind or at least two combination, further preferably propylene glycol alginate.
6. according to claim 1-5 any one of them antibacterial and protective films, which is characterized in that the moisturizer is glycerine, third
Any one in glycol, aloe water, vitamin E, polyethylene glycol or D-sorbite or at least two combination, further preferably
Glycerine.
7. according to claim 1-6 any one of them antibacterial and protective films, which is characterized in that the plant extracts is grape pip
Any one in extract, cherry extract, aloe extract, ginkgo biloba p.e, Lotus Plumule P.E. or wolfberry fruit extract
Or at least two combination, further preferably grape seed extract；
Preferably, the preservative for imidazolidinyl urea, interior uride, isothiazolinone, p-hydroxybenzoate, benzoic acid or
Any one in potassium sorbate or at least two combination, further preferably imidazolidinyl urea；
Preferably, the solubilizer is polyoxyethylene hardened castor oil, Emulsifier EL-60, fatty alcohol polyoxyethylene ether, fat
Any one in fat alcohol polyoxyethylene polyoxypropylene ether, polyoxyethylene sorbitan fatty acid ester or polyglyceryl fatty acid ester
Or at least two combination, further preferably fatty alcohol polyoxyethylene ether；
Preferably, the freshener be menthol, menthyl lactate, amide of mint, menthyl succinate, N- ethyls-to peppermint
Any one in base -3- formamides or 2-Isopropyl-N,2,3-trimethylbutyramide or at least two combination, further preferably
For amide of mint.
8. according to claim 1-7 any one of them antibacterial and protective films, which is characterized in that each component in the antibacterial and protective film
And its content is：
Wherein, compound ion anti-biotic material carries out intercalation by pyridine ion liquid and inorganic nano layer compound alpha-phosphate hydrogen zirconium
Assembling is prepared.
9. according to the preparation method of claim 1-8 any one of them antibacterial and protective films, which is characterized in that the described method includes
Following steps：
By the compound ion anti-biotic material of formula ratio, film forming agent, thickener, moisturizer, nano silver, plant extract agent, preservative,
Solubilizer, freshener and water are added in container, are uniformly mixed, and 1~3h are kept the temperature in 60~80 DEG C, then heat to 120~
Antimicrobial spray is made in 150 DEG C of 2~5h of heat preservation, natural cooling.
10. according to the purposes of claim 1-8 any one of them antibacterial and protective films, which is characterized in that antibacterial and protective film is sprayed
It is applied on human skin；
Preferably, antibacterial and protective film is sprayed on hand and/or facial skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611046107.5A CN108078959A (en) | 2016-11-22 | 2016-11-22 | A kind of antibacterial and protective film and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611046107.5A CN108078959A (en) | 2016-11-22 | 2016-11-22 | A kind of antibacterial and protective film and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108078959A true CN108078959A (en) | 2018-05-29 |
Family
ID=62170959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611046107.5A Pending CN108078959A (en) | 2016-11-22 | 2016-11-22 | A kind of antibacterial and protective film and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108078959A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108077311A (en) * | 2016-11-22 | 2018-05-29 | 北京中科艾利特科技有限公司 | A kind of antimicrobial spray of haze and its preparation method and application |
| CN109675069A (en) * | 2019-02-26 | 2019-04-26 | 山东科宏医疗科技有限公司 | A kind of medical sterilization ultrasonic coupling agent and preparation method thereof |
| WO2020000284A1 (en) * | 2018-06-28 | 2020-01-02 | L'oreal | Film-forming cosmetic composition comprising polyurethane and cross-linked starch |
| CN111387207A (en) * | 2020-03-17 | 2020-07-10 | 安徽工大化工科技有限公司 | High-molecular antibacterial and bactericidal composite film spraying agent and preparation method thereof |
| CN111802409A (en) * | 2020-06-23 | 2020-10-23 | 武汉理工大学 | Broad-spectrum antiviral antibacterial disinfectant and preparation method and application thereof |
| CN112807278A (en) * | 2019-11-15 | 2021-05-18 | 湖北远大天天明制药有限公司 | Nasal composition and preparation method and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6096513A (en) * | 1983-10-31 | 1985-05-30 | Natl Inst For Res In Inorg Mater | Zirconium hydrogenphosphate compound and its preparation |
| CN1367677A (en) * | 1998-12-22 | 2002-09-04 | 宝洁公司 | Transparent skin care compositions |
| CN1843124A (en) * | 2006-03-17 | 2006-10-11 | 何素梅 | Nano silver coating agent for sterilization and its preparation method |
| CN101198375A (en) * | 2005-06-14 | 2008-06-11 | 西姆莱斯有限责任两合公司 | Mixtures comprising anthranilic acid amides and cooling agents as cosmetic and pharmaceutical compositions for alleviating itching |
| CN102113484A (en) * | 2010-10-29 | 2011-07-06 | 中国科学院过程工程研究所 | Preparation method of composite anti-bacterium material |
| CN105025870A (en) * | 2012-12-12 | 2015-11-04 | 西姆莱斯股份公司 | Preparations |
| CN106234439A (en) * | 2016-08-09 | 2016-12-21 | 北京赛特瑞科技发展有限公司 | A kind of superbacteria antibiosis and sterilization agent and its production and use |
| CN108077311A (en) * | 2016-11-22 | 2018-05-29 | 北京中科艾利特科技有限公司 | A kind of antimicrobial spray of haze and its preparation method and application |
-
2016
- 2016-11-22 CN CN201611046107.5A patent/CN108078959A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6096513A (en) * | 1983-10-31 | 1985-05-30 | Natl Inst For Res In Inorg Mater | Zirconium hydrogenphosphate compound and its preparation |
| CN1367677A (en) * | 1998-12-22 | 2002-09-04 | 宝洁公司 | Transparent skin care compositions |
| CN101198375A (en) * | 2005-06-14 | 2008-06-11 | 西姆莱斯有限责任两合公司 | Mixtures comprising anthranilic acid amides and cooling agents as cosmetic and pharmaceutical compositions for alleviating itching |
| CN1843124A (en) * | 2006-03-17 | 2006-10-11 | 何素梅 | Nano silver coating agent for sterilization and its preparation method |
| CN102113484A (en) * | 2010-10-29 | 2011-07-06 | 中国科学院过程工程研究所 | Preparation method of composite anti-bacterium material |
| CN105025870A (en) * | 2012-12-12 | 2015-11-04 | 西姆莱斯股份公司 | Preparations |
| CN106234439A (en) * | 2016-08-09 | 2016-12-21 | 北京赛特瑞科技发展有限公司 | A kind of superbacteria antibiosis and sterilization agent and its production and use |
| CN108077311A (en) * | 2016-11-22 | 2018-05-29 | 北京中科艾利特科技有限公司 | A kind of antimicrobial spray of haze and its preparation method and application |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108077311A (en) * | 2016-11-22 | 2018-05-29 | 北京中科艾利特科技有限公司 | A kind of antimicrobial spray of haze and its preparation method and application |
| WO2020000284A1 (en) * | 2018-06-28 | 2020-01-02 | L'oreal | Film-forming cosmetic composition comprising polyurethane and cross-linked starch |
| CN112888424A (en) * | 2018-06-28 | 2021-06-01 | 欧莱雅 | Film-forming cosmetic composition comprising polyurethane and cross-linked starch |
| US11779534B2 (en) | 2018-06-28 | 2023-10-10 | L'oreal | Film-forming cosmetic composition comprising polyurethane and cross-linked starch |
| CN112888424B (en) * | 2018-06-28 | 2023-11-21 | 欧莱雅 | Film-forming cosmetic composition comprising polyurethane and crosslinked starch |
| CN109675069A (en) * | 2019-02-26 | 2019-04-26 | 山东科宏医疗科技有限公司 | A kind of medical sterilization ultrasonic coupling agent and preparation method thereof |
| CN112807278A (en) * | 2019-11-15 | 2021-05-18 | 湖北远大天天明制药有限公司 | Nasal composition and preparation method and application thereof |
| CN111387207A (en) * | 2020-03-17 | 2020-07-10 | 安徽工大化工科技有限公司 | High-molecular antibacterial and bactericidal composite film spraying agent and preparation method thereof |
| CN111802409A (en) * | 2020-06-23 | 2020-10-23 | 武汉理工大学 | Broad-spectrum antiviral antibacterial disinfectant and preparation method and application thereof |
| CN111802409B (en) * | 2020-06-23 | 2021-10-29 | 武汉理工大学 | Broad-spectrum antiviral antibacterial disinfectant and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108078959A (en) | A kind of antibacterial and protective film and its preparation method and application | |
| CN106234439B (en) | A kind of superbacteria antibiosis and sterilization agent and its preparation method and application | |
| CN108077311A (en) | A kind of antimicrobial spray of haze and its preparation method and application | |
| CN101970560A (en) | Disinfectant alcohol-soluble quaternary ammonium polymers | |
| TW200900004A (en) | Disinfectant | |
| CN102317429A (en) | Antimicrobial foamable soaps | |
| CN105055642A (en) | Compound guanidine disinfectant and preparation method of compound guanidine disinfectant | |
| JP6129843B2 (en) | Disinfecting compositions and their use | |
| Hayat et al. | Antibacterial effectiveness of commercially available hand sanitizers | |
| EP2563356A2 (en) | A composition for skin sanitization and protection and method of its use | |
| CN105163580A (en) | Process for producing silver-ion antibacterial liquid, silver-ion antibacterial liquid produced by said process, and silver-ion-containing product containing said antibacterial liquid | |
| BRPI0714379A2 (en) | Method of cleaning a material, composition, Method of treating a material, and Method of manufacturing a composition | |
| CN102754668A (en) | Novel Chinese herbal medicine compound disinfectant solution | |
| MX2008006507A (en) | Pathogen - controlling products. | |
| EP1689416A1 (en) | Disinfecting composition and methods of making and using same | |
| WO2006087569A2 (en) | Antimicrobial composition comprising an extract of tarchonanthus camphoratus | |
| CN103668945A (en) | Anti-mite antibacterial agent special for textiles | |
| Shah et al. | Formulation, evaluation, and antibacterial efficiency of herbal hand wash Gel | |
| CN111493097A (en) | Collective disinfectant for inhibiting viruses and pathogenic bacteria and preparation method thereof | |
| CN103783089B (en) | Compound Chinese herbal medicine disinfectant for tableware and kitchenware disinfection | |
| CN106283625A (en) | A kind of antibacterial and deodouring spray for textile | |
| CN108935526A (en) | A kind of cordate houttuynia silver ion composite disinfectant | |
| CN104798823A (en) | Bactericide for clinical laboratory | |
| CN101460053A (en) | Methods and articles having a high antiviral and antibacterial efficacy | |
| CN111500490A (en) | Microbial type bacteriostatic and odor-removing preparation as well as preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20200109 Address after: NO.67 Baiyunshan Road, Fuxin street, Fushan District, Yantai City, Shandong Province Applicant after: Zhongkongirit (Yantai) Technology Development Co., Ltd Address before: 100190 No. 1 north of Haidian District, Haidian District, Beijing, No. 1 (west area of the Institute of process engineering, Chinese Academy of Sciences) Applicant before: Beijing Saiterui Science & Technology Development Co., Ltd. |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20200929 Address after: 100190 No. 1 north of Haidian District, Haidian District, Beijing, No. 1 (west area of the Institute of process engineering, Chinese Academy of Sciences) Applicant after: BEIJING CENTURY SCIENCE AND TECHNOLOGY DEVELOPMENT Co.,Ltd. Address before: NO.67 Baiyunshan Road, Fuxin street, Fushan District, Yantai City, Shandong Province Applicant before: Zhongkongirit (Yantai) Technology Development Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180529 |
|
| RJ01 | Rejection of invention patent application after publication |