CN109675069A - A kind of medical sterilization ultrasonic coupling agent and preparation method thereof - Google Patents
A kind of medical sterilization ultrasonic coupling agent and preparation method thereof Download PDFInfo
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- CN109675069A CN109675069A CN201910145795.8A CN201910145795A CN109675069A CN 109675069 A CN109675069 A CN 109675069A CN 201910145795 A CN201910145795 A CN 201910145795A CN 109675069 A CN109675069 A CN 109675069A
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- coupling agent
- ultrasonic coupling
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- medical sterilization
- medical
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- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 39
- 239000007822 coupling agent Substances 0.000 title claims abstract description 38
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 48
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000004925 Acrylic resin Substances 0.000 claims abstract description 13
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 claims abstract description 12
- 239000008213 purified water Substances 0.000 claims abstract description 12
- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 claims abstract description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 8
- -1 polypropylene Polymers 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 7
- 239000000523 sample Substances 0.000 abstract description 7
- 238000002604 ultrasonography Methods 0.000 abstract description 6
- 206010011409 Cross infection Diseases 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 5
- 206010029803 Nosocomial infection Diseases 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 14
- 241000894006 Bacteria Species 0.000 description 5
- 239000000645 desinfectant Substances 0.000 description 5
- 239000004909 Moisturizer Substances 0.000 description 4
- 230000001333 moisturizer Effects 0.000 description 4
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical class OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229960003500 triclosan Drugs 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920002413 Polyhexanide Polymers 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- LPNITZFOZWXKMB-UHFFFAOYSA-N acetic acid;molecular chlorine Chemical compound ClCl.CC(O)=O LPNITZFOZWXKMB-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960002233 benzalkonium bromide Drugs 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 1
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229960002152 chlorhexidine acetate Drugs 0.000 description 1
- 229960005443 chloroxylenol Drugs 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002068 microbial inoculum Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Abstract
The present invention relates to a kind of medical sterilization ultrasonic coupling agents and preparation method thereof.The medical sterilization ultrasonic coupling agent, including effective component are cross-linked polyacrylic resin, glycerol, propylene glycol, isothiazolinone, p-hydroxybenzoate, neutralizer and purified water.Medical sterilization ultrasonic coupling agent of the present invention is in aqueous, good water solubility, has disinfection to medical ultrasonic probe, skin, is provided simultaneously with good acoustic performance, safety and stability；In addition, ultrasonic coupling agent of the invention belongs to gel-like disinfection couplant, disinfection can reach without impregnating, sterilizing time is short, realizes the sterilizing in entire detection process to ultrasonic probe, easy to use；Possible cross-infection risk during ultrasound detection is effectively reduced.
Description
Technical field
The present invention relates to a kind of medical sterilization ultrasonic coupling agents and preparation method thereof, belong to the technology of medical ultrasonic coupling agent
Field.
Background technique
Medical ultrasonic coupling agent is the gel preparation that must be used when human body makees ultrasonic examination.It is to reduce ultrasound that it, which is acted on,
Acoustic reactance resistance between probe and skin is poor, to reduce the reflection loss of ultrasonic energy, furthermore also acts as lubricating action, makes ultrasound
Probe, which can be slided flexibly, to be detected.
" Regulations of sterilization management " Article 6 that the 27th command of Ministry of Health of the People's Republic of China 2002 is promulgated and 2006
" hospital infection management method " chapter 3 Article 12 that 48th command is promulgated provides: the Medical treatment device of all contact skin and mucous membrane
Tool, utensil and article must reach sterilisation level.
Now widely used medical ultrasonic coupling agent majority does not have sterilizing function, and the subject of different health status makees
During ultrasound detection, it is inevitably present the risk of cross-infection, ultrasonic probe is propagated as nosocomial infection pathogen
Important medium, feel bacterium and drug-fast bacteria for institute and provide diffusion conditions.
In order to efficiently solve the sterilization problems in ultrasound detection, industry personnel is conducted extensive research.Chinese patent
The disclosed medical ultrasonic coupling agent with disinfection function of publication number CN101219223A, is killed wherein joined triclosan class
Microbial inoculum；Ultrasonic coupling agent disclosed in China Patent Publication No. CN1679968A is using chlorhexidine acetate as disinfectant；It is Chinese special
Medical sterilization ultrasonic coupling agent disclosed in sharp publication number CN101773673A selects to be disinfectant to chloroxylenol；It is Chinese special
Ultrasonic coupling agent disclosed in sharp publication number CN101249268A then uses poly hexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, vinegar
One of sour Chlorhexidine, triclosan and nano silver or combinations thereof.The disclosed couplant with sterilizing function of the prior art is more
With gel-type vehicle cross-linked polyacrylic resin, sodium alginate, Sodium Polyacrylate and clean new, the acetic acid chlorine of disinfectant triclosan, phenol oneself
The compatibilities such as fixed, quaternary ammonium salt, provide disinfection function.These disinfectants or poorly water-soluble, or prohibit with gel-type vehicle with compatibility
Avoid, then will affect transparency, safety and the stability of gel products using higher dosage.
Therefore, research and development are safe and stable, and easy to use and with disinfecting and sterilizing functions medical ultrasonic coupling agents have
Very important meaning.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of medical sterilization ultrasonic coupling agent.
The present invention also provides a kind of preparation methods of above-mentioned medical sterilization ultrasonic coupling agent.
Term explanation:
Cross-linked polyacrylic resin: product name carbomer is a kind of outstanding gel-type vehicle, there is the important use such as thickening, suspension
On the way, it is widely used in lotion, cream, in gel.
Purified water: drinking water is through hyoscine made from the way of distillation, ion-exchange, hyperfiltration or other suitable methods
Water, be free of any additive.
The technical solution of the present invention is as follows:
A kind of medical sterilization ultrasonic coupling agent, the weight percent including effective component be, cross-linked polyacrylic resin 0.3~
1.2%, glycerol 2.0~10.0%, propylene glycol 2.0~10.0%, isothiazolinone 0.01~0.1%, p-hydroxybenzoate
0.1~1.0%, neutralizer 0.2~1.5%, surplus are purified water.
The effect of cross-linked polyacrylic resin is to form water soluble polymer gel, and glycerol functions as moisturizer,
Have effects that water conservation and greasy skin；The solvent for functioning as fungicide of propylene glycol is also used as moisturizer, propylene glycol sheet
Body has moistening effect, but moistening effect is not so good as glycerol, and propylene glycol is used in mixed way with glycerol, and moistening effect is more preferable；Isothiazole
The effect of quinoline ketone and p-hydroxybenzoate is to kill bacterium, mould and virus；The effect of neutralizer is to neutralize crosslinked polypropylene
Acid resin adjusts couplant product pH value；
Preferred according to the present invention, the neutralizer is the mixing of triethanolamine or sodium hydroxide or both arbitrary proportion.
A kind of preparation method of medical sterilization ultrasonic coupling agent, includes the following steps:
1) cross-linked polyacrylic resin and purified water are weighed respectively by weight percentage, cross-linked polyacrylic resin is dissolved in purifying
In water, solution A is obtained, indwelling is spare；
2) p-hydroxybenzoate and propylene glycol are weighed respectively by weight percentage, p-hydroxybenzoate is dissolved in into propylene glycol
In, stirring obtains solution B, indwelling is spare；
3) isothiazolinone weighed by weight percentage is added in the solution B, obtains solution C, indwelling is spare；
4) the resulting solution C of step 3) is continued to stir after being added under stirring in the resulting solution A of step 1)
30~60 minutes, evenly spread to solution C in solution A；Glycerol weighed by weight percentage and neutralizer are added, finally
Purified water is supplemented, pH value is adjusted 5.5~8.0, obtains colorless and transparent gel；
5) clear gel obtained by filling step 4), obtains medical sterilization ultrasonic coupling agent finished product.
The invention has the benefit that
1. medical sterilization ultrasonic coupling agent of the present invention is in aqueous, good water solubility, there is disinfection to medical ultrasonic probe, skin
Effect, is provided simultaneously with good acoustic performance, safety and stability；Disappear in addition, ultrasonic coupling agent of the invention belongs to gel-like
Malicious couplant can reach disinfection without impregnating, and sterilizing time is short, realizes and kills in entire detection process to ultrasonic probe
Bacterium disinfection, it is easy to use；Possible cross-infection risk during ultrasound detection is effectively reduced, protection subject's body is strong
Health, and it is free from environmental pollution；
2. medical sterilization ultrasonic coupling agent of the present invention maintains the character and coupling function of conventional medical ultrasonic coupling agent,
Select to human body and it is environmentally friendly, to the non-corrosive isothiazolinone of silastic product, p-hydroxybenzoate as sterilization
The medical ultrasonic coupling agent with disinfection function of transparent gel-form is prepared in agent；It is verified, all originals of inventive formulation
Material is that incompatibility is not present between disinfectant and thickener to human body and environmentally friendly product in use scope,
His ingredient does not occur chemical reaction between each other yet and generates harmful substance, meets YY0299-2016's " medical ultrasonic coupling agent "
Professional standard；
3. medical sterilization ultrasonic coupling agent of the present invention, low using concentration, sterilizing ability is strong, good with gel-type vehicle compatibility,
The transparency of gel products will not be influenced because additive amount increases；
4. the preparation method of medical sterilization ultrasonic coupling agent of the present invention, simple process, raw material are easy to get, investment of production equipment
Few, operating cost is low, is conducive to industrialized production.
Detailed description of the invention
Fig. 1 is the preparation flow figure of medical sterilization ultrasonic coupling agent of the present invention.
Specific embodiment
Below with reference to embodiment and Figure of description, the present invention will be further described, but not limited to this.
Embodiment 1
The medical sterilization ultrasonic coupling agent of 100g, including effective component are cross-linked polyacrylic resin 1g, glycerol 15g, propylene glycol
15g, isothiazolinone 0.05g, p-hydroxybenzoate 0.5g, neutralizer 1g, surplus are purified water.Its neutralizer is three ethyl alcohol
The mixing of amine and sodium hydroxide 1:1 ratio.
The effect of cross-linked polyacrylic resin is to form water soluble polymer gel, and glycerol functions as moisturizer,
Have effects that water conservation and greasy skin；The solvent for functioning as fungicide of propylene glycol is also used as moisturizer, propylene glycol sheet
Body has moistening effect, but moistening effect is not so good as glycerol, and propylene glycol is used in mixed way with glycerol, and moistening effect is more preferable；Isothiazole
The effect of quinoline ketone and p-hydroxybenzoate is to kill bacterium, mould and virus；The effect of neutralizer is to neutralize crosslinked polypropylene
Acid resin adjusts couplant product pH value.
Embodiment 2
As shown in Figure 1.
The preparation method of medical sterilization ultrasonic coupling agent, includes the following steps: as described in implementing 1
1) cross-linked polyacrylic resin 1g and purified water 30g are weighed respectively, cross-linked polyacrylic resin is dissolved in purified water, are obtained
To solution A, indwelling is spare；
2) p-hydroxybenzoate 0.5g and propylene glycol 15g are weighed respectively, p-hydroxybenzoate is dissolved in propylene glycol, are stirred
It mixes, obtains solution B, indwelling is spare；
3) it weighs isothiazolinone 0.05g to be added in the solution B, obtains solution C, indwelling is spare；
4) the resulting solution C of step 3) is continued to stir after being added under stirring in the resulting solution A of step 1)
50 minutes, evenly spread to solution C in solution A；Glycerol 15g and neutralizer 1g are added, purified water 37.45 is finally supplemented,
PH value is adjusted 5.5~8.0, obtains colorless and transparent gel；
5) clear gel obtained by filling step 4), obtains medical sterilization ultrasonic coupling agent finished product.
To medical sterilization ultrasonic coupling agent made from the present embodiment, performance indicator, sanitary index and functional parameter carry out
Sampling Detection, testing result meet the requirements.Test results in the following table:
Upper table data show, all properties index of the present embodiment product all meet " disinfection technology standard " (version in 2002) and
The requirement of YY0299-2016 medical ultrasonic coupling agent.
Claims (3)
1. a kind of medical sterilization ultrasonic coupling agent, which is characterized in that the weight percent including effective component is crosslinked polypropylene
Acid resin 0.3~1.2%, glycerol 2.0~10.0%, propylene glycol 2.0~10.0%, isothiazolinone 0.01~0.1%, to hydroxyl
Yl benzoic acid ester 0.1~1.0%, neutralizer 0.2~1.5%, surplus are purified water.
2. medical sterilization ultrasonic coupling agent according to claim 1, which is characterized in that the neutralizer be triethanolamine or
The mixing of sodium hydroxide or both arbitrary proportion.
3. the preparation method of medical sterilization ultrasonic coupling agent as claimed in claim 1 or 2, which is characterized in that including walking as follows
It is rapid:
1) cross-linked polyacrylic resin and purified water are weighed respectively by weight percentage, cross-linked polyacrylic resin is dissolved in purifying
In water, solution A is obtained, indwelling is spare；
2) p-hydroxybenzoate and propylene glycol are weighed respectively by weight percentage, p-hydroxybenzoate is dissolved in into propylene glycol
In, stirring obtains solution B, indwelling is spare；
3) isothiazolinone weighed by weight percentage is added in the solution B, obtains solution C, indwelling is spare；
4) the resulting solution C of step 3) is continued to stir after being added under stirring in the resulting solution A of step 1)
30~60 minutes, evenly spread to solution C in solution A；Glycerol weighed by weight percentage and neutralizer are added, finally
Purified water is supplemented, pH value is adjusted 5.5~8.0, obtains colorless and transparent gel；
5) clear gel obtained by filling step 4), obtains medical sterilization ultrasonic coupling agent finished product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113769119A (en) * | 2021-10-15 | 2021-12-10 | 山东科宏医疗科技有限公司 | Medical ultrasonic coupling agent and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773673A (en) * | 2010-03-18 | 2010-07-14 | 薛海燕 | Medical sterilization ultrasonic coupling agent and preparation method thereof |
| CN106620734A (en) * | 2016-12-20 | 2017-05-10 | 江西宜信堂医疗科技有限公司 | Sterile medical ultrasonic coupling patch and preparation method thereof |
| CN108078959A (en) * | 2016-11-22 | 2018-05-29 | 北京赛特瑞科技发展有限公司 | A kind of antibacterial and protective film and its preparation method and application |
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2019
- 2019-02-26 CN CN201910145795.8A patent/CN109675069A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773673A (en) * | 2010-03-18 | 2010-07-14 | 薛海燕 | Medical sterilization ultrasonic coupling agent and preparation method thereof |
| CN108078959A (en) * | 2016-11-22 | 2018-05-29 | 北京赛特瑞科技发展有限公司 | A kind of antibacterial and protective film and its preparation method and application |
| CN106620734A (en) * | 2016-12-20 | 2017-05-10 | 江西宜信堂医疗科技有限公司 | Sterile medical ultrasonic coupling patch and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113769119A (en) * | 2021-10-15 | 2021-12-10 | 山东科宏医疗科技有限公司 | Medical ultrasonic coupling agent and preparation method thereof |
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