CN101773673A - Medical sterilization ultrasonic coupling agent and preparation method thereof - Google Patents
Medical sterilization ultrasonic coupling agent and preparation method thereof Download PDFInfo
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- CN101773673A CN101773673A CN 201010130205 CN201010130205A CN101773673A CN 101773673 A CN101773673 A CN 101773673A CN 201010130205 CN201010130205 CN 201010130205 CN 201010130205 A CN201010130205 A CN 201010130205A CN 101773673 A CN101773673 A CN 101773673A
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Abstract
The invention provides a medical sterilization ultrasonic coupling agent and a preparation method thereof. The coupling agent comprises the following main components by the weight percentage: 0.2-0.6% of p-chlor-m-xylenol, 4-8% of propylene glycol, 4-8% of glycerine, 0.3-1.2% of crosslinking polyacrylic acid resin, 0.2-1.2% of sodium hydroxide, and 80-90% of distilled water; the preparation method thereof comprises the steps: (1) dissolving crosslinking polyacrylic acid resin in distilled water to obtain liquor A; (2) dissolving p-chlor-m-xylenol in propylene glycol to obtain liquor B; (3) mixing and stirring the liquor A and liquor B, neutralizing with sodium hydroxide and adding glycerine to obtain the finished product. The invention not only meets the property and functions of medical sterilization ultrasonic coupling agent, but also has efficient and disinfectant effect and causes an ultrasonic probe to always maintain at the disinfectant state, thus completely solving the problem that the ultrasonic probe can not realize the effective disinfection in short time. The invention reduces the risk of the mutual pathogenic bacteria cross-infection among ultrasonic examinees and is beneficial to the health of people.
Description
Technical field
The present invention relates to medical ultrasonic coupling agent, particularly a kind of medical sterilization ultrasonic coupling agent and preparation method thereof.
Background technology
Medical ultrasonic coupling agent is the gel preparation that human body must be used when doing ultrasonic examination.Its effect is that elimination ultrasonic probe and human body are examined the air between the skin of position, strengthen the coupling between ultrasonic probe and the human body skin, make sound wave conduction not be subjected to air influence and decay, obtaining reliable result, for doctor's correct diagnosis provides foundation.And present widely used medical ultrasonic coupling agent majority is not possess sterilizing function, causes the doctor numerous person-times of different health status being done exist the risk of person under inspection's mutual pathogenic bacteria cross infection inevitably in the process of ultrasound detection.In order to solve the sterilization problems in the ultrasound detection effectively, personnel have carried out the research of different depth in the industry, and still, because the particularity of ultrasonic probe material and instructions for use, people can not adopt has the disinfectant of corrosivity and swellability to plastics and rubber; Can not use conventional infusion method to carry out disinfection; More can not realize between the person under inspection in limited blanking time, finishing sterilizing operation.Now disclosed numerical example has the medical ultrasonic coupling agent achievement in research of disinfective action, the censorship that has as a result unsatisfactory, the complicated process of preparation that has of disinfection indicator, have skin is had certain stimulation, so fail up to now to apply.Thereby the sterilization problems of ultrasonic probe is still the difficult problem that medical profession does not achieve a solution as yet.
Summary of the invention
The invention provides a kind of medical sterilization ultrasonic coupling agent and preparation method thereof; purpose is to have by development the medical ultrasonic coupling agent of sterilizing function; to realize that ultrasonic probe just can obtain to disinfect at short notice; thereby reduce the pathogenic bacterium cross infection risk that may cause in the medical supersonic testing process, the protection person under inspection's is healthy.
Technical solution of the present invention:
The main component of the medical sterilization ultrasonic coupling agent that the present invention is alleged is disinfectant and solvent thereof, the lubricant of preserving moisture, resin, nertralizer, moisture, and described disinfectant is that parachlorometaxylenol, solvent are propylene glycol, the lubricant of preserving moisture is glycerol, resin is the crosslinked polypropylene acid resin, nertralizer is sodium hydroxide, moisture is distilled water.The percentage by weight that above-mentioned component contains active ingredient is followed successively by: 0.2-0.6%, 4-8%, 4-8%, 0.3-1.2%, 0.2-1.2%, distilled water are 80-90%.
The preparation method of the medical sterilization ultrasonic coupling agent that the present invention is alleged comprises the following steps:
(1) take by weighing the crosslinked polypropylene acid resin of 0.3-1.2% and the distilled water of 80-90% by weight percentage respectively, the crosslinked polypropylene acid resin is dissolved in the distilled water, gently stir, static 10-14 hour, obtain cross linked polyacrylate resin liquor A, keep somewhere;
(2) take by weighing the parachlorometaxylenol of 0.2-0.6% and the propylene glycol of 4-8% by weight percentage respectively, parachlorometaxylenol is dissolved in the propylene glycol liquid fully, stirs, get liquor B, keep somewhere;
(3) with the liquor B of step (two) gained, the liquor A that stir on the limit, the limit adds step () gained, continue to stir 5-10 minute, the sodium hydroxide and the percentage by weight 4-8% glycerol that add percentage by weight 0.2-1.2% again replenish an amount of distilled water then, treat stirring under that formation is colourless till the light-coloured transparent gel;
(4) fill step (three) gained clear gel is the medical sterilization ultrasonic coupling agent finished product.
Beneficial effect of the present invention
(1) the present invention goes through up to a hundred tests and the medical supersonic couplant preparation of achieving success, effect with high-effective disinfecting, and to environment and body harmless, to silastic product and metallic article non-corrosiveness, solved the difficult problem that former medical ultrasonic coupling agent can not carry out disinfection to ultrasonic probe, the present invention just can effectively sterilize ultrasonic probe at short notice, allow the person under inspection detect the process that finishes from beginning to accept to detect, all the time be under the disinfection, thereby reduced the person under inspection each other because of the risk of pathogenic bacterium cross infections.
(2) complex preparation of the present invention for optimizing, in the main component that is screened, parachlorometaxylenol is to antibacterial, and mycete and viral lethality are strong, and price is lower, the raw material abundance; The crosslinked polypropylene acid resin is the polymer substance that forms spawn; Sodium hydroxide can in and the crosslinked polypropylene acid resin, make the gel couplant be neutral; Glycerol can be preserved moisture and lubricated skin.Thereby this complex preparation not only has the high-effective disinfecting effect, more can satisfy the function of medical ultrasonic coupling agent, and the air between isolated ultrasonic probe and the human body skin makes sound wave conduct undamped influence, can obtain reliable result.
(3) preparation of the present invention and using method are simple, and no new pollutant produce in the preparation process; The sample of product is respectively through Jiangsu Prov. Disease Preventing and Controlling Center and Nanjing University's detection that acoustic investigation extracts, and its sterilization index of correlation, the velocity of sound and relative acoustic attenuation numerical value all are better than the national regulation value, and skin is had no stimulation.
The specific embodiment
Embodiment one:
The preparation gross weight is the medical sterilization ultrasonic coupling agent of 1000 grams:
(1) takes by weighing the 2 crosslinked polypropylene acid resins that restrain and be dissolved in the distilled water that weight is 800 grams, gently stir, static 10 hours, obtain cross linked polyacrylate resin liquor A; Keep somewhere;
(2) take by weighing the parachlorometaxylenol of 3 grams and the propylene glycol of 40 grams, parachlorometaxylenol is dissolved in the propylene glycol liquid fully, stirs, obtain liquor B, keep somewhere;
(3) the liquor B that step (two) is obtained, the liquor A that stir on the limit, the limit adds step () acquisition continues to stir 5 minutes, add sodium hydroxide 2 gram and glycerol 40 grams again, supply distilled water by total amount 1000 then, treat stirring under formation colourless to the light-coloured transparent gel only;
(4) fill step (three) gained medical sterilization ultrasonic coupling agent finished product.
Embodiment two:
The preparation gross weight is the medical sterilization ultrasonic coupling agent of 1000 grams:
(1) takes by weighing the 8 crosslinked polypropylene acid resins that restrain and be dissolved in the distilled water that weight is 900 grams, gently stir, static 14 hours, obtain cross linked polyacrylate resin liquor A;
(2) take by weighing the parachlorometaxylenol of 6 grams and the propylene glycol of 80 grams, parachlorometaxylenol is dissolved in the propylene glycol liquid fully, stirs, obtain liquor B, keep somewhere;
(3) the liquor B that step (two) is obtained, the liquor A that stir on the limit, the limit adds step () acquisition continues to stir 10 minutes, add sodium hydroxide 12 gram and glycerol 80 grams again, supply distilled water by total amount 1000 then, treat under the stirring that formation is colourless till the light-coloured transparent gel;
(4) fill step (three) gained medical sterilization ultrasonic coupling agent finished product.
Embodiment three:
The preparation gross weight is the medical sterilization ultrasonic coupling agent of 1000 grams:
(1) takes by weighing the 6 crosslinked polypropylene acid resins that restrain and be dissolved in the distilled water that weight is 850 grams, gently stir, static 12 hours, obtain cross linked polyacrylate resin liquor A;
(2) take by weighing the parachlorometaxylenol of 5 grams and the propylene glycol of 60 grams, parachlorometaxylenol is dissolved in the propylene glycol liquid fully, stirs, obtain liquor B, keep somewhere;
(3) the liquor B that step (two) is obtained, the liquor A that stir on the limit, the limit adds step () acquisition continues to stir 8 minutes, add sodium hydroxide 8 gram and glycerol 60 grams again, supply distilled water by total amount 1000 then, treat under the stirring that formation is colourless till the light-coloured transparent gel;
(4) fill step (three) gained medical sterilization ultrasonic coupling agent finished product.
Embodiment four:
The preparation gross weight is the medical sterilization ultrasonic coupling agent of 1000 grams:
(1) takes by weighing the 8 crosslinked polypropylene acid resins that restrain and be dissolved in the distilled water that weight is 830 grams, gently stir, static 13 hours, obtain cross linked polyacrylate resin liquor A;
(2) take by weighing the parachlorometaxylenol of 4 grams and the propylene glycol of 50 grams, parachlorometaxylenol is dissolved in the propylene glycol liquid fully, stirs, obtain liquor B, keep somewhere;
(3) the liquor B that step (two) is obtained, the liquor A that stir on the limit, the limit adds step () acquisition continues to stir 7 minutes, add sodium hydroxide 10 gram and glycerol 50 grams again, supply distilled water by total amount 1000 then, treat under the stirring that formation is colourless till the light-coloured transparent gel;
(4) fill step (three) gained medical sterilization ultrasonic coupling agent finished product.
Claims (2)
1. medical sterilization ultrasonic coupling agent, main component is disinfectant and solvent thereof, the lubricant of preserving moisture, resin, nertralizer, moisture, it is characterized in that: described disinfectant is that parachlorometaxylenol, solvent are propylene glycol, the lubricant of preserving moisture is glycerol, resin is the crosslinked polypropylene acid resin, nertralizer is sodium hydroxide, moisture is distilled water, and the percentage by weight that above-mentioned component contains active ingredient is followed successively by: 0.2-0.6%, 4-8%, 4-8%, 0.3-1.2%, 0.2-1.2%, distilled water are 80-90%.
2. the preparation method of a medical sterilization ultrasonic coupling agent, it is characterized in that: it comprises the following steps:
(1) take by weighing the crosslinked polypropylene acid resin of 0.3-1.2% and the distilled water of 80-90% by weight percentage respectively, the crosslinked polypropylene acid resin is dissolved in the distilled water, gently stir, static 10-14 hour, obtain cross linked polyacrylate resin liquor A, keep somewhere;
(2) take by weighing the parachlorometaxylenol of 0.2-0.6% and the propylene glycol of 4-8% by weight percentage respectively, parachlorometaxylenol is dissolved in the propylene glycol liquid fully, stirs, get liquor B, keep somewhere;
(3) with the liquor B of step (two) gained, the liquor A that stir on the limit, the limit adds step () gained, continue to stir 5-10 minute, the sodium hydroxide and the percentage by weight 4-8% glycerol that add percentage by weight 0.2-1.2% again replenish an amount of distilled water then, treat stirring under that formation is colourless till the light-coloured transparent gel;
(4) fill step (three) gained clear gel, this is the medical sterilization ultrasonic coupling agent finished product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010130205 CN101773673A (en) | 2010-03-18 | 2010-03-18 | Medical sterilization ultrasonic coupling agent and preparation method thereof |
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| CN 201010130205 CN101773673A (en) | 2010-03-18 | 2010-03-18 | Medical sterilization ultrasonic coupling agent and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028961A (en) * | 2010-12-04 | 2011-04-27 | 蔡永军 | Ultrasonic coupling agent used by traumatic patient after surgery |
| CN103751813A (en) * | 2014-02-11 | 2014-04-30 | 北京大学 | ultrasound couplant for photoacoustic tomography and preparation method thereof |
| CN105688233A (en) * | 2016-03-10 | 2016-06-22 | 王盛梅 | Medical disinfecting ultrasonic coupling agent |
| CN109298079A (en) * | 2018-09-25 | 2019-02-01 | 上海新高桥凝诚建设工程检测有限公司 | A kind of couplant and preparation method thereof suitable for the test of the structure velocity of sound |
| CN109675068A (en) * | 2019-02-26 | 2019-04-26 | 山东科宏医疗科技有限公司 | A kind of medical ultrasonic coupling agent and preparation method thereof with sterilizing function |
| CN109675069A (en) * | 2019-02-26 | 2019-04-26 | 山东科宏医疗科技有限公司 | A kind of medical sterilization ultrasonic coupling agent and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100542615C (en) * | 2007-01-10 | 2009-09-23 | 重庆安碧捷生物科技有限公司 | Has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof |
-
2010
- 2010-03-18 CN CN 201010130205 patent/CN101773673A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100542615C (en) * | 2007-01-10 | 2009-09-23 | 重庆安碧捷生物科技有限公司 | Has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 《中国医学影像技术》 20090420 牛凤岐等 医用超声耦合剂--超声科医师应该了解的知识和信息 715-717 1-2 第25卷, 第4期 2 * |
| 《环境与健康杂志》 20041120 杜达安等 消毒剂中有效成分--对氯间二甲苯酚、三氯羟基二苯醚的高效液相色谱测定法 408-409 1-2 第21卷, 第6期 2 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028961A (en) * | 2010-12-04 | 2011-04-27 | 蔡永军 | Ultrasonic coupling agent used by traumatic patient after surgery |
| CN103751813A (en) * | 2014-02-11 | 2014-04-30 | 北京大学 | ultrasound couplant for photoacoustic tomography and preparation method thereof |
| CN103751813B (en) * | 2014-02-11 | 2016-02-17 | 北京大学 | A kind of ultrasonic coupling agent for photoacoustic tomography and preparation method thereof |
| CN105688233A (en) * | 2016-03-10 | 2016-06-22 | 王盛梅 | Medical disinfecting ultrasonic coupling agent |
| CN109298079A (en) * | 2018-09-25 | 2019-02-01 | 上海新高桥凝诚建设工程检测有限公司 | A kind of couplant and preparation method thereof suitable for the test of the structure velocity of sound |
| CN109675068A (en) * | 2019-02-26 | 2019-04-26 | 山东科宏医疗科技有限公司 | A kind of medical ultrasonic coupling agent and preparation method thereof with sterilizing function |
| CN109675069A (en) * | 2019-02-26 | 2019-04-26 | 山东科宏医疗科技有限公司 | A kind of medical sterilization ultrasonic coupling agent and preparation method thereof |
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Application publication date: 20100714 |