CN100542615C - Has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof - Google Patents
Has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof Download PDFInfo
- Publication number
- CN100542615C CN100542615C CNB2007100781129A CN200710078112A CN100542615C CN 100542615 C CN100542615 C CN 100542615C CN B2007100781129 A CNB2007100781129 A CN B2007100781129A CN 200710078112 A CN200710078112 A CN 200710078112A CN 100542615 C CN100542615 C CN 100542615C
- Authority
- CN
- China
- Prior art keywords
- glycerol
- diphenyl ether
- coupling agent
- dihydroxy diphenyl
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The present invention relates to have the medical ultrasonic coupling agent of disinfection function, the percentage by weight of composition is: 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0.2-2%, glycerol 4-7%, crosslinked polypropylene acid resin 0.6-1.5%, sodium hydroxide 0.8-1.2%, distilled water 89.0-94.0%.Its preparation process is as follows, and the first step takes by weighing 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether and glycerol by weight percentage, and with 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether dissolves in the glycerol liquid fully, keeps somewhere; In second step, take by weighing the crosslinked polypropylene acid resin by weight percentage and be dissolved in the distilled water; The solution that the first step is obtained is under agitation added in the solution that second step obtained, and then, supplies distilled water and hydro-oxidation sodium solution, makes into gel.The present invention can carry out sterilizing to ultrasonic probe in checking process, reduced cross infection; Preparation technology is simple, and is free from environmental pollution.
Description
Technical field
The present invention relates to a kind of medical ultrasonic coupling agent and preparation method thereof with disinfecting and sterilizing functions.
Background technology
The function of traditional medical ultrasonic coupling agent is the coupling of strengthening between ultrasonic probe and the human body skin, and isolated ultrasonic probe and be examined air between the skin of position makes the sound wave conduction not be subjected to air influence and decays, to reach good detection effect.CN1087016A disclose " preparation method of medical ultrasonic coupling agent " be get 5 the gram CPB 1 be that acrylate copolymer is that carbomer-1 type material was put into water 5～6 hours, after it is expanded, adding 20% sodium hydroxide solution makes its pH value between 6.8～7.2, add sodium benzoate and glycerol then, stirring adds water to 1000ml.Medical ultrasonic coupling agent with this method preparation is the same with traditional medical ultrasonic coupling agent, does not have the function of sterilization.The sterilization of ultrasonic probe is a great problem that always perplexs medical supersonic diagnostic detection and treatment, main cause has three: (1) no suitable compound, the particularity of ultrasonic probe material, the disinfectant that has determined at present great majority on the market that these plastics and rubber are had corrosivity and a swellability can not be used for the sterilization of ultrasonic probe; (2) no suitable medium, the particularity of structure of ultrasonic makes it can not use the most frequently used infusion method to carry out disinfection, to the requirement height of medium; (3) disinfecting time, because of the operating frequency height, the blanking time between the tested patient is very short, usually about 1 minute, internal energy while kill bacteria of short time like this, the disinfectant of mycete and virus is not also gone public at least at present.CN1108956A discloses " coupling agent for medical ultrasonic diagnostic probe and preparation method thereof ", coupling agent with this method preparation is made up of thickening agent NS-90, solubilizing agent tween-80, disinfectant 1522, antibacterial sorbic acid, inclusion compound α-CD, spice, pigment, can play the sterilizing effect, avoid cross infection, and harmless to the person, to the instrument probe not damaged.But preparation technology is comparatively complicated, need add the water stirring during use and leave standstill, and is not too convenient.
Summary of the invention
The purpose of this invention is to provide a kind of medical ultrasonic coupling agent with disinfection function, it does not have any corrosivity and swellability to ultrasonic probe, and soaking-free can reach disinfective action, and disinfection time is short, can in whole testing process, carry out sterilizing to ultrasonic probe, easy to use; Can reduce the cross infection risk that may bring in the medical supersonic testing process, the person under inspection is healthy in protection, and free from environmental pollution.
Another object of the present invention provides a kind of preparation method with medical ultrasonic coupling agent of disinfection function, and preparation section is simple, uses equipment investment few.
Medical ultrasonic coupling agent with disinfection function of the present invention, the percentage by weight that contains active ingredient is:
2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether, (Triclosan, molecular formula: C
12HTCl
3O
2), 0.2-2%; Its effect is: kill bacteria, mycete and virus;
Glycerol (Glycerine; Glycerol, molecular formula: CH2 (OH) CH (OH) CH2 (OH)) 4-7%; Its effect is: dissolving 2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether, lubricated skin;
Crosslinked polypropylene diluted acid resin, (Carbomer, molecular formula: [CH2-CH-] N-COOH) 0.6-1.5%; Its effect is: the polymer substance that forms spawn;
Sodium hydroxide 0.8-1.2%; Its effect is: in and crosslinked polypropylene diluted acid resin, make couplant finished product gel and be neutral;
Distilled water 89.0-94.0%.
The character and the coupling function that have at first kept the conventional medical ultrasonic coupling agent in the present invention's prescription, through up to a hundred tests, in numerous disinfectant, filter out a kind of internationally recognized, to environment and body harmless, to silastic product and the non-corrosive efficient germicide of metallic article---2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether, after the glycerol dissolving, on the traditional product basis, the disinfection sterilizing type ultrasonic coupling agent of new generation of the transparent gel-form of preparing.The present invention fill a prescription all raw materials all be through checking to human body and environmentally friendly Green Product, chemical reaction does not take place and produce new harmful substance each other.
The present invention has solved ultrasonic probe disinfectant Three Difficult Issues at one stroke by science, design cleverly:
(1) new and effective antibacterial 2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether and parabens chemical compound do not have any corrosivity and swellability to ultrasonic probe, can be used for the sterilization of ultrasonic probe fully.
(2) with scientific methods antibacterial is dissolved, be molecularity and be distributed in the couplant that is transparent gel-form, become the gel disinfectant, soaking-free can reach disinfective action, has solved media problem.
(3) ultrasonic probe begins to detect the patient to detecting end Zi contacting couplant, and ultrasonic probe is under the disinfection all the time in whole testing process, has thoroughly solved and can not realize effective disinfectant problem in the short time.
Described preparation method with medical ultrasonic coupling agent of disinfection function, preparation process is as follows,
The first step: take by weighing by weight percentage 0.2-2% 2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether and 4-7% glycerol, with take by weighing 2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether dissolves in the glycerol liquid that takes by weighing fully, keeps somewhere;
Second step: take by weighing 0.6-1.5% crosslinked polypropylene diluted acid resin by weight percentage and be dissolved in the distilled water of weight 25%-45%, obtain crosslinked polypropylene diluted acid resin solution;
The 3rd step: contain 2 with what the first step obtained, 4, the glycerol lysate of 4 '-trichlorine-2 '-dihydroxy diphenyl ether, after under agitation adding in the second cross linked polyacrylate resin solution that obtain of step, continue to stir five minutes, then, 9.0-94.0% of percentage supply distilled water by weight, and slow the dropping accounts for 0.8-1 of gross weight under stirring.2% sodium hydroxide solution makes into gel, get final product neutral white or milky gel sterilization type medical ultrasonic coupling agent finished product;
The 4th step: fill.
Required manufacturing equipment: common vessel, stirring and emulsifying device, auto-filling equipment.These equipment are simple and easy to, and need not very complicated tip device, any one tame pharmaceutical factory, and Cosmetics Plant or Toothpaste Factory all can utilize existing device production.
The medical ultrasonic coupling agent with disinfection function according to above prescription and preparation method make has carried out sampling Detection to its character, pH value, sanitary index and functional parameter, and testing result meets the requirements.The detection content sees the following form:
| Test item | Examination criteria | Testing result | Judge |
| Character | White or milky gel | The milky gel, no bubble, no layering | Qualified |
| PH value | 6.5±1.0 | 7.2 | Qualified |
| Sanitary index: | |||
| Total number of bacteria | ≤ 1000/gram | ≤ 100/gram | Qualified |
| Staphylococcus aureus | Must not detect | Do not pick | Qualified |
| Escherichia coli | Must not detect | Do not pick | Qualified |
| Bacillus pyocyaneus | Must not detect | Do not pick | Qualified |
| Candida albicans | Must not detect | Do not pick | Qualified |
| Functional parameter: | |||
| Staphylococcus aureus | Killing rate 〉=99.9% | ≥99.99％ | Qualified |
| Escherichia coli | Killing rate 〉=99.9% | ≥99.99％ | Qualified |
| Bacillus pyocyaneus | Killing rate 〉=99.9% | ≥99.99％ | Qualified |
| Candida albicans | Killing rate 〉=90.0% | ≥99％ | Qualified |
| Hepatitis B surface antigen | Killing rate 〉=99.9% | 100％ | Qualified |
The present invention compares with prior art and has the following advantages: can kill pathogenic microbes such as various bacteria, fungus, virus, in whole testing process, ultrasonic probe is carried out sterilizing, significantly reduced the cross infection risk that to bring in the medical supersonic testing process, protected the person under inspection healthy, and easy to use; Preparation technology is simple, and equipment is obtained easily, and is free from environmental pollution.
The specific embodiment
Embodiment 1:
The preparation gross weight is the medical ultrasonic coupling agent with disinfection function of 1000 grams.
The first step: take by weighing 2,4 of gross weight 0.2%, 4 '-trichlorine-2 '-dihydroxy diphenyl ether, 2 restrain, and take by weighing the glycerol liquid of gross weight 4%, 40 grams, with 2 grams 2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether dissolves in the 40 gram glycerol liquid fully, keeps somewhere;
Second step: crosslinked polypropylene diluted acid resin 6 grams that take by weighing gross weight 0.6% are dissolved in an amount of 250 gram distilled water, obtain crosslinked polypropylene diluted acid resin solution;
The 3rd step: contain 2 with what the first step obtained, 4, after the glycerol lysate of 4 '-trichlorine-2 '-dihydroxy diphenyl ether is under agitation added the second crosslinked polypropylene diluted acid resin solution that obtain of step, continue to stir five minutes, then, supply distilled water 691 grams by weight, and the sodium hydroxide solutions that slow dropping 8 grams-12 restrain under stirring, make into gel, and adjust pH value between 6.5 ± 1.0, get final product neutral white or milky gel disinfection sterilizing type medical supersonic couplant finished product.
The 4th step: fill.
Embodiment 2: the preparation gross weight is the medical ultrasonic coupling agent with disinfection function of 1000 grams.
The first step: take by weighing 2,4 of gross weight 1.2%, 4 '-trichlorine-2 '-dihydroxy diphenyl ether, 12 restrain, and take by weighing the glycerol liquid of gross weight 5.5%, 55 grams, with 12 grams 2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether dissolves in the 55 gram glycerol liquid fully, keeps somewhere;
Second step: crosslinked polypropylene diluted acid resin 10 grams that take by weighing gross weight 1.0% are dissolved in an amount of 350 gram distilled water, obtain crosslinked polypropylene diluted acid resin solution;
The 3rd step: contain 2 with what the first step obtained, 4, the glycerol lysate of 4 '-trichlorine-2 '-dihydroxy diphenyl ether under agitation add second go on foot behind the crosslinked polypropylene diluted acid resin solution of pavilion, continue to stir five minutes, then, supply distilled water 537 grams by weight, and the sodium hydroxide solutions that slow dropping 8 grams-12 restrain under stirring, make into gel, and adjust pH value between 6.5 ± 1.0, get final product neutral white or milky gel disinfection sterilizing type medical supersonic couplant finished product.
The 4th step: fill.
Embodiment 3: the preparation gross weight is the medical ultrasonic coupling agent with disinfection function of 1000 grams.
The first step: take by weighing 2,4 of gross weight 2%, 4 '-trichlorine-2 '-dihydroxy diphenyl ether, 20 restrain, and take by weighing the glycerol liquid of gross weight 7%, 70 grams, with 20 grams 2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether dissolves in the 70 gram glycerol liquid fully, keeps somewhere;
Second step: crosslinked polypropylene diluted acid resin 15 grams that take by weighing gross weight 1.5% are dissolved in an amount of 450 gram distilled water, obtain crosslinked polypropylene diluted acid resin solution;
The 3rd step: contain 2 with what the first step obtained, 4, after the glycerol lysate of 4 '-trichlorine-2 '-dihydroxy diphenyl ether is under agitation added the second crosslinked polypropylene diluted acid resin solution that obtain of step, continue to stir five minutes, then, supply distilled water 449 grams by weight, and the sodium hydroxide solutions that slow dropping 8 grams-12 restrain under stirring, make into gel, and adjust pH value between 6.5 ± 1.0, get final product neutral white or milky gel disinfection sterilizing type medical supersonic couplant finished product.
The 4th step: fill.
Claims (2)
1, the medical ultrasonic coupling agent that has disinfection function, the percentage by weight that contains effective composition is:
2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether 0.2-2%, glycerol 4-7%, crosslinked polypropylene acid resin 0.6-1.5%, sodium hydroxide 0.8-1.2%, distilled water 89.0-94.0%.
2, the preparation method with medical ultrasonic coupling agent of disinfection function as claimed in claim 1, preparation process is as follows,
The first step: take by weighing by weight percentage 0.2-2% 2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether and 4-7% glycerol, with take by weighing 2,4,4 '-trichlorine-2 '-dihydroxy diphenyl ether dissolves in the glycerol liquid fully, keeps somewhere;
Second step: take by weighing 0.6-1.5% crosslinked polypropylene acid resin by weight percentage and be dissolved in the distilled water of weight 25%-45%, obtain the cross linked polyacrylate resin solution;
The 3rd step: contain 2 with what the first step obtained, 4, the glycerol lysate of 4 '-trichlorine-2 '-dihydroxy diphenyl ether, after under agitation adding in the second cross linked polyacrylate resin solution that obtain of step, continue to stir five minutes, then, 9.0-94.0% of percentage supply distilled water by weight, and under stirring, slowly drip 0.8-1.2% the sodium hydroxide solution that accounts for gross weight, make into gel, get final product neutral white or milky gel sterilization type medical ultrasonic coupling agent finished product;
The 4th step: fill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100781129A CN100542615C (en) | 2007-01-10 | 2007-01-10 | Has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100781129A CN100542615C (en) | 2007-01-10 | 2007-01-10 | Has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101219223A CN101219223A (en) | 2008-07-16 |
| CN100542615C true CN100542615C (en) | 2009-09-23 |
Family
ID=39629485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2007100781129A Active CN100542615C (en) | 2007-01-10 | 2007-01-10 | Has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100542615C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773673A (en) * | 2010-03-18 | 2010-07-14 | 薛海燕 | Medical sterilization ultrasonic coupling agent and preparation method thereof |
| CN102133409A (en) * | 2011-03-18 | 2011-07-27 | 青岛明药堂医药科技开发有限公司 | Sterilizing type medical ultrasonic coupling agent and preparation method thereof |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698107A (en) * | 2009-09-03 | 2010-04-28 | 顾海 | Sterilizing medical ultrasonic coupling agent |
| CN101711882B (en) * | 2009-12-22 | 2011-06-22 | 武汉耦合医学科技有限责任公司 | Medical ultrasound coupling agent with function of fast and efficient sterilization and device thereof |
| CN101797391B (en) * | 2010-03-12 | 2012-01-25 | 苏州御芙蓉日化有限公司 | Disposable bactericidal medical ultrasonic couplant and preparation method thereof |
| CN101920023B (en) * | 2010-04-24 | 2013-03-13 | 王勇 | Transrectal ultrasound medical coupling agent |
| CN101810867A (en) * | 2010-04-28 | 2010-08-25 | 重庆安碧捷生物科技有限公司 | Medical disinfecting and sterilizing ultrasonic coupling agent and preparation method thereof |
| CN101862460B (en) * | 2010-04-28 | 2012-02-15 | 重庆安碧捷生物科技有限公司 | Sterilizing medicinal ultrasonic coupling agent and preparation method thereof |
| CN102370996B (en) * | 2010-08-11 | 2014-02-05 | 香港理工大学 | Concentrated ultrasonic conducting resin and its preparation method and use method |
| CN102688507A (en) * | 2011-03-23 | 2012-09-26 | 安徽深蓝医疗科技有限公司 | Disinfection and sterilization couplant and its preparation method |
| CN102580122B (en) * | 2012-03-06 | 2013-08-14 | 江苏壹叁玖医疗器械有限公司 | Method for preparing medical disinfection couplant |
| CN102716503A (en) * | 2012-06-04 | 2012-10-10 | 周郗竹 | Medical ultrasonic coupling agent and preparation method thereof |
| CN105031674A (en) * | 2015-08-28 | 2015-11-11 | 天津市紫晖医疗电子仪器有限公司 | Disinfectant medical ultrasonic coupling agent and production process thereof |
-
2007
- 2007-01-10 CN CNB2007100781129A patent/CN100542615C/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773673A (en) * | 2010-03-18 | 2010-07-14 | 薛海燕 | Medical sterilization ultrasonic coupling agent and preparation method thereof |
| CN102133409A (en) * | 2011-03-18 | 2011-07-27 | 青岛明药堂医药科技开发有限公司 | Sterilizing type medical ultrasonic coupling agent and preparation method thereof |
| CN102133409B (en) * | 2011-03-18 | 2012-07-11 | 青岛明药堂医药科技开发有限公司 | Sterilizing type medical ultrasonic coupling agent and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101219223A (en) | 2008-07-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100542615C (en) | Has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof | |
| JP6010224B2 (en) | Method of physical antimicrobial treatment | |
| CN1816330B (en) | Antiseptic compositions, methods and systems | |
| CN1845877B (en) | Oxidative reductive potential water solution, processes for producing same and methods of using the same | |
| CN101716354B (en) | Ultrasonic coupling agent | |
| CN106421217B (en) | A kind of solution of benzalkonium chloride and preparation method thereof | |
| CN106466319A (en) | Antimicrobial compositions and using method | |
| CN102387793A (en) | Antiseptic compositions comprising silver ions and menthol and uses thereof | |
| WO2015027752A1 (en) | Antibacterial medical ultrasonic coupling agent and preparation method thereof | |
| CN102178962A (en) | Medical disinfection/sterilization ultrasound couplant and preparation method thereof | |
| CN106692997B (en) | A kind of disinfection sterilizing type solid-state medical supersonic coupled patch and preparation method thereof | |
| CN101718465B (en) | Self-heating medical ultrasonic coupling agent device with sterilization and disinfection effects and preparation thereof | |
| CN108030774A (en) | A kind of carboxymethyl chitosan nanoparticle and its synthetic method for loading light dynamic pasteurization medicine | |
| CN101773673A (en) | Medical sterilization ultrasonic coupling agent and preparation method thereof | |
| CN104667304A (en) | Ultrasonic coupling agent and preparation method thereof | |
| CN102688507A (en) | Disinfection and sterilization couplant and its preparation method | |
| CN102113981A (en) | Non-rinse pregnant woman perineum medical care gel and preparation method thereof | |
| CN101698107A (en) | Sterilizing medical ultrasonic coupling agent | |
| CN102149392B (en) | The gentle non-stimulated skin antiseptic without alcohol | |
| CN108939095A (en) | Preparation method of antibacterial type ultrasonic coupling agent and products thereof and application | |
| CN106620734B (en) | A kind of sterile medical supersonic coupled patch and preparation method thereof | |
| CN111973801B (en) | Hydrogel for anti-inflammatory repair and preparation method thereof | |
| CN102085382B (en) | Special sterilizing medical ultrasound couplant for ophthalmology and preparation method thereof | |
| CN107638573B (en) | Antibacterial medical ultrasonic coupling agent and preparation method thereof | |
| CN101711882B (en) | Medical ultrasound coupling agent with function of fast and efficient sterilization and device thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: CHONGQING AMBITION TECHNOLOGY CO., LTD. Free format text: FORMER NAME: CHONGQING ANBIJIE BIOTECHNOLOGY CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: 400700, Beibei science and technology incubator Park, No. 79, natural road, Beibei, Chongqing, A-208 Patentee after: Chongqing Anbijie Technology Co., Ltd. Address before: 400715, block A, No. 79, natural road, Beibei District, Chongqing, 208 Patentee before: Chongqing Anbijie Biotechnology Co., Ltd. |
|
| CP02 | Change in the address of a patent holder |
Address after: 404100 Longan Avenue, Dongcheng Street, Tongliang District, Chongqing Patentee after: Chongqing Anbijie Technology Co., Ltd. Address before: No. 79 Tiansheng Road, Beibei District, Chongqing 400700 (A-208, Beibei Science and Technology Incubation Park) Patentee before: Chongqing Anbijie Technology Co., Ltd. |
|
| CP02 | Change in the address of a patent holder |