CN102133409A - Sterilizing type medical ultrasonic coupling agent and preparation method thereof - Google Patents
Sterilizing type medical ultrasonic coupling agent and preparation method thereof Download PDFInfo
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- CN102133409A CN102133409A CN 201110066846 CN201110066846A CN102133409A CN 102133409 A CN102133409 A CN 102133409A CN 201110066846 CN201110066846 CN 201110066846 CN 201110066846 A CN201110066846 A CN 201110066846A CN 102133409 A CN102133409 A CN 102133409A
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Abstract
The invention relates to a sterilizing type medical ultrasonic coupling agent and a preparation method thereof. The coupling agent contains the following active ingredients: polyhexamthylene guanidine-derivatives and chloramphenicol. A test proves that the coupling agent provided by the invention has the effects of transmitting sound, lubricating and preventing cross-infection, and the preparation method is simple and environment-friendly.
Description
Technical field
The present invention relates to a kind of couplant, be specifically related to a kind of medical ultrasonic coupling agent and preparation method thereof with sterilization.
Background technology
The medical supersonic wave frequency is 2.5-5M, can not conduct in air.If have air in probe and the skin, ultrasound wave returns once running into air, does not advance in the human body, and is super less than the inspection effect.Therefore, need on skin, be coated with the last layer couplant earlier, just can eliminate the air of probe and skin.
Couplant is the water soluble polymer colloid, and is functional, thereby the air that can get rid of between probe and the skin makes clear image, non-stimulated to skin zero damage, nontoxic, and no anaphylaxis is pollution-free.
When conventional ultrasonic wave is diagnosed, for fear of the cavity mucous membrane cross infection, the normal probe that adopts condom or probe sheath to entangle couplant, outside condom or probe sheath, all smear couplant then, in view of the probe sheath punching rate reach 8-81%, the punching rate of condom reaches 0.9-2.0%, and probe has the chance that contacts mucosa with couplant.
According to big Leah medical ultrasonic association (ASUM) the communique report in May, 2005, according to popping one's head in the tightness degree of patient's contact, the application of ultrasonic probe is divided into three ranks: the one, low-risk behavior:, comprise abdominal part, breast and organella imaging etc. with intact contact skin; The 2nd, middle risk behavior: contact with mucosa, comprise eye, the ultrasonic diagnosis of rectum, vagina and perineum part; The 3rd, the excessive risk behavior: directly contact with blood products, comprise in the art and blood vessel in etc. the ultrasonic diagnosis at position, it can be said that this operational approach has middle risk row and do not reach the purpose that prevents cross infection.
Therefore develop a kind of safety, bacteriostasis property good, can prevent that the couplant of medical cross infection has great importance.Find that by retrieval present ultrasonic coupling agent mainly is divided into following several:
CN201010159213.0 disinfection sterilizing type medical supersonic couplant and preparation method thereof contains 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0.05-2%, R-polysaccharide 0.1-2%, propylene glycol 2-7%, glycerol 2-7%, crosslinked polypropylene diluted acid resin 0.6-1.5%, distilled water 80.5-95.25%; In addition, the triethanolamine that adds above-mentioned gross weight 0.8-1.2%.Its preparation process is as follows: the mixed solution of preparation propylene glycol and glycerol; With 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether and R-polysaccharide dissolve in the mixed solution that is mixed with fully; Preparation crosslinked polypropylene diluted acid resin solution; The mixed solution of preparation is added in the crosslinked polypropylene diluted acid resin solution, formed gelatinous polymer substance; Drip triethanolamine solution in addition, make the ultrasonic coupling agent that obtains be neutral.
CN201010159203.7 medical ultrasonic coupling agent with disinfection function and preparation method thereof contains R-polysaccharide 0.1-2%, propylene glycol 2-7%, glycerol 2-7%, crosslinked polypropylene acid resin 0.6-1.5%, distilled water 82.5-95.3%; In addition, the triethanolamine that adds above-mentioned gross weight 0.8-1.2%.Its preparation process is as follows: the mixed solution of preparation propylene glycol and glycerol; With the R-polysaccharide, dissolve in fully in the mixed solution that is mixed with; Preparation cross linked polyacrylate resin solution; The mixed solution that contains the R-polysaccharide of preparation is added in the cross linked polyacrylate resin solution, formed gelatinous polymer substance, and supply distilled water, stir; Slowly drip triethanolamine solution in addition, make the ultrasonic coupling agent that obtains be neutral.
CN201010130205.3 medical sterilization ultrasonic coupling agent and preparation method thereof, the main component and the weight percentages of this couplant are: parachlorometaxylenol 0.2-0.6%, propylene glycol 4-8%, glycerol 4-8%, crosslinked polypropylene acid resin 0.3-1.2%, sodium hydroxide 0.2-1.2%, distilled water 80-90%.
CN200910230493.7 bactericidal medical ultrasonic couplant and preparation method thereof, described bactericidal medical ultrasonic couplant, comprise 6g carbomer, 6g triethanolamine, 10g-25g glycerol and 0.075g-0.15g antibacterial barbaloin in every 1000ml distilled water, make the bactericidal properties medical ultrasonic coupling agent of preparation in this way have good bactericidal action, but this natural plant extracts price of barbaloin is expensive in the prescription, makes the product cost height.
The medical ultrasonic coupling agent of a CN200910113444.5 disinfection, by weight percentage, select CB940 type carbomer 0.3-0.7% for use, parachlorometaxylenol 0.015-0.035%, sodium hydroxide 0.15-0.35%, 75% ethanol 1.5-3.5%, surplus is the two distilled water that obtain that steam of deionization.Used antibacterial ethanol may make the couplant of preparation in this way can influence the ultrasonoscopy effect in the technical scheme that this invention provides, and Diazolidinyl Urea, this product also is not suitable for being applied to the detection of tract, mucosa and imperfect skin.
CN200810026888.0 disinfection sterilizing type medical supersonic couplant and preparation method thereof, ultrasonic coupling agent comprises wherein a kind of viscosity modifier of hydroxyethyl-cellulose, carbomer, hydroxypropyl cellulose, propylene glycol and deionized water, wherein also contain 0.05～0.15% antibacterial, described antibacterial component is selected from the combination of poly hexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, Trichlorophenoxy diphenyl ether, nanometer silver any one or they, the couplant of preparing with this method can play the effect of sterilizing, can avoid cross infection.But comprise hydroxypropyl cellulose, hydroxyethyl-cellulose and nanometer silver in the combination of the prescription of this patent, the coupling agent for medical use that studies show that compositions such as containing hydroxypropyl cellulose, hydroxyethyl-cellulose not only damages probe, chafe, even may damage skin and mucosa; The inorganic antiseptic nanometer silver does not meet the requirement of ultrasonics in addition.
CN200710078112.9 has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof, the percentage by weight of composition is: 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0.2-2%, glycerol 4-7%, crosslinked polypropylene acid resin 0.6-1.5%, sodium hydroxide 0.8-1.2%, distilled water 89.0-94.0%.
There is following several defective in present used medical ultrasonic coupling agent: the one, and component utilized relative complex or component cost are higher relatively; The 2nd, there is not sterilization; The 3rd, can not be applied to the detection of tract, mucosa and imperfect skin.In order to overcome the problem that existing couplant exists, the present invention proposes a kind of couplant of forming by chloromycetin and polyhexamethylene guanidine and other adjuvants, the relevant report that does not have chloromycetin and polyhexamethylene guanidine to share does not at present have the two and adjuvant to form the report of couplant yet.
Summary of the invention
The purpose of this invention is to provide a kind of use when being used for skin and cavity mucous membrane ultrasonic diagnosis have a quick and long lasting disinfection coupling agent for medical use that prevents medical cross infection.
Another object of the present invention provides a kind of preparation method with medical ultrasonic coupling agent of disinfection function.
Disinfection sterilizing type medical supersonic couplant provided by the invention contains following active component: poly hexamethylene biguanide and chloromycetin.
Preferably, disinfection sterilizing type medical supersonic couplant provided by the invention contains the active component of following percentage by weight: poly hexamethylene biguanide 0.02-0.05% and chloromycetin 0.2-0.30%.
Disinfection sterilizing type medical supersonic couplant provided by the invention, the percentage by weight that also contains effective composition is: carbomer 0.50-0.90%, glycerol 3.00-7.00%, propylene glycol 3.00-7.00%, sodium hydroxide 0.15-0.25% and deionized water 84.50-93.13%.
Preferably, medical ultrasonic coupling agent with disinfecting and sterilizing functions of the present invention, form by following component in percentage by weight: poly hexamethylene biguanide 0.02-0.05%, chloromycetin 0.20-0.30%, carbomer 0.50-0.90%, glycerol 3.00-6.00%, propylene glycol 3.00-6.00%, sodium hydroxide 0.15-0.25%, deionized water 86.50-93.13%.
Wherein said carbomer is as the polymer substance that forms spawn;
Described glycerol is mainly used in the dissolving poly hexamethylene biguanide and plays lubricated moisture-keeping function;
Described propylene glycol is mainly used in the dissolved chlorine mycin and plays lubricated moisture-keeping function;
Described poly hexamethylene biguanide is a kind of environment-friendly type macromolecule polymer disinfection sanitizer, has the sterilization wide spectrum; Valid density is low; Speed of action is fast; Stable in properties; Premium properties soluble in water; Can use at normal temperatures; Antibacterial for a long time, have no side effect; Non-corrosiveness; Colourless, nothing is smelt; Nontoxic; Do not fire, not quick-fried, do not damage probe, easy-clear, the medicated clothing of not making dirty, have excellent biological compatibility, strong adhesion, greasy property good, stable under the ultrasound wave effect, safely, meet the principle of medical science and ultrasonics; Moderate; Convenient transportation can be described as best antibacterial.In fact, this product is a kind of environment-friendly multipurpose new polymers, in industrial, agriculture, medical and daily life purposes is extremely widely arranged.
Chloromycetin is chloromycetin series antibiotics.At external tool wide spectrum anti-microbial effect, comprise aerobic gram-negative bacteria and gram positive bacteria, anaerobe, rickettsiae, spirillum and chlamydiaceae.To the bactericidal action of following antibacterial tool: hemophilus influenza, streptococcus pneumoniae and Neisseria meningitidis.Following antibacterial is only had a bacteriostasis: anaerobe such as staphylococcus aureus, micrococcus scarlatinae, Streptococcus viridans, B group Hemolytic streptococcus, escherichia coli, Klebsiella Pneumoniae, proteus mirabilis, Salmonella typhi, bacillus paratyphosus, Shigella, bacteroides fragilis.With the poly hexamethylene biguanide coupling synergism of stronger sterilization sterilization is arranged.
Described sodium hydroxide is used for and carbomer, makes the couplant finished product become neutral gel.
The present invention also provides a kind of preparation to have the method for the medical ultrasonic coupling agent of disinfection function, may further comprise the steps:
1) carbomer is joined in the deionized water, and under water-bath 50-68 ℃, be stirred to dissolving fully, keep somewhere;
2) poly hexamethylene biguanide is dissolved in deionized water fully, joins then in the glycerol, keep somewhere;
3) chloromycetin is dissolved in the propylene glycol fully, keeps somewhere;
4) sodium hydroxide is dissolved in the deionized water fully, keeps somewhere;
5) with step 2) and 3) join behind the mixed solution mix homogeneously that obtains in the carbomer solution that step 1) obtains and be stirred to evenly, add remaining deionized water then, and slowly the dropping sodium solution stirring is extremely even under stirring, make into neutral gel, keep somewhere cool to room temperature, fill.
Coupling agent for medical use with sterilizing effect provided by the invention has the following advantages:
1) disinfection medical ultrasonic coupling agent of the present invention is united use poly hexamethylene biguanide and chloromycetin, makes it bring into play quick and long lasting disinfection function in couplant of the present invention.
Gross weight with couplant counts 1, and when poly hexamethylene biguanide consumption＜0.02%, the couplant of making does not reach antibacterial and sterilization effects; When poly hexamethylene biguanide consumption＞0.05%, in producing the couplant process, can make carbomer aggregate into bulk, and the couplant color is turned white opaque;
When the consumption of chloromycetin is lower than 0.2%, can not work in coordination with the effect that reaches quick sterilization with poly hexamethylene biguanide; Consumption is higher than 0.3% bactericidal effect that can not improve couplant on the original basis again, and raw material is caused waste, influences the cost of product;
When the consumption of carbomer less than 0.5%, the couplant of making is viscosity＜15Pas when 25 ℃ of tests, does not meet the viscosity requirement of couplant, such couplant in use flowability is bigger, is unfavorable for ultrasonic diagnosis; When the consumption of carbomer greater than 0.9%, the couplant of making is viscosity＞80Pas when 25 ℃ of tests, do not meet the viscosity requirement of couplant, such couplant viscosity is too big, be unfavorable for fill in the production process, be unfavorable for being coated with in the ultrasonic diagnosis process and put on the skin, and the ultrasonic probe that obtains lead sound effective value;
2) by the disinfection sterilizing type medical supersonic couplant that provides of the present invention, quality is lubricated fine and smooth, bright and lustrous, do not contain bubble, denseness is moderate, can not trickle during use, easily extrude again, coating performance is good, be difficult for drying, pH value is neutral or near neutral, can kill pathogenic microbes such as multiple pathogenic bacteria, virus and antibacterial simultaneously fast, nontoxic non-stimulated to skin, constant product quality is difficult for becoming sour and goes mouldy, and it is good to lead acoustic performance, the resolution height, ultrasonoscopy is clear, is applied to behind the skin easy to cleanly, and life-time service can corrosion probe etc.;
3) the present invention adopts above-mentioned prescription and technological process, materials economy, prepare easy, suitable batch production large-scale production.
4) compared with prior art, advantage of the present invention is to utilize the collaborative bacteriostasis and sterilization effect of poly hexamethylene biguanide and chloromycetin, makes the couplant that utilizes the present invention to prepare have effective germ-resistant effect fast.
5) carrying out B ultrasonic when diagnosis, the couplant that utilizes the present invention to prepare can be applied to the detection of tract, mucosa and damaged skin, and antibiotic adopted bacteriostasis property is good, can effectively guard against iatrogenic price differential to infect, and safety, effectively has no side effect.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Commercially available 20% poly hexamethylene biguanide that uses among the following embodiment is meant the aqueous solution of poly hexamethylene biguanide, contains percentage by weight in this aqueous solution and be 20% poly hexamethylene biguanide.
Embodiment 1
1, feed intake: throwing total amount by formula proportion is the material of 1000g couplant, that is:
2, preparation method:
1) takes by weighing various compositions respectively according to recipe quantity;
2) carbomer 5.0g is joined in the 400g deionized water, and under water-bath 50-68 ℃, be stirred to dissolving fully, keep somewhere;
3) 20% poly hexamethylene biguanide 1.0g is dissolved in the 30.0g glycerol fully, keeps somewhere;
4) chloromycetin 3.0g is dissolved in the propylene glycol of 30g fully, keeps somewhere;
5) the 1.5g sodium hydroxide that takes by weighing is dissolved in 100 ionized waters fully, keeps somewhere
6) with step 3) and 4) add step 2 behind the mixed solution mix homogeneously that obtains) be stirred to evenly in the carbomer solution that obtains, add remaining deionized water then, and the slow sodium hydroxide solution that adds is stirred to evenly under stirring, makes into neutral gel, keep somewhere cool to room temperature, fill.
3, the medical ultrasonic coupling agent for preparing according to above prescription and method with sterilizing effect, by its outward appearance, viscosity, pH value, the velocity of sound, acoustic characteristic impedance, acoustic attenuation coefficient slope, biocompatibility, stability, bactericidal property etc. have been carried out comprehensive inspection, testing result sees the following form:
Concrete detection method is:
1) outward appearance: sample is injected the 100mL glass dish, and upper surface is wipeed off, under non-direct light in indoor visual observation;
2) viscosity: adopt the rotating cylinder viscometer method in two appendix of the Pharmacopoeia of the People's Republic of China " viscosimetry ", under 25 ℃ of temperature, measure;
3) pH value: adopt " pH value algoscopy " measurement in two appendix of the Pharmacopoeia of the People's Republic of China;
4) velocity of sound: according to method described in the GB/T15261, measure under a certain frequency in 35 ℃ and 2.5MHz-5.0MHz scope, sample length is not less than 5cm;
5) acoustic characteristic impedance: by the acoustic velocity value and the density value (kg/m that record in 4.3
3) multiply each other and try to achieve;
6) acoustic attenuation: according to method described in the GB/T15261, measure with two sample methods under the optional frequency between 35 ℃ and 2.5MHz-5.0MHz, and revise with regard to acoustic attenuation in the water, the difference of bright sample length must not be less than 5cm.
7) biocompatibility experiment:
Add the ratio of 20mL lixiviate medium in the 2g sample, (37+1) ℃, (24+2) h prepares experimental liquid, the lixiviate medium: the MEM culture medium.
Get experimental liquid and undertaken by the lixiviating solution test method of stipulating among the GB/T16886.5-2003, cell-cytotoxic reaction should be not more than 2 grades;
Sample thief sticks test method according to the sealing of stipulating among the GB/T16886.10-2005 to carry out, and should not have the sensitization of skin reaction;
Sample thief carries out according to regulation test method among the GB/T16886.10-2005, observes behind the contact 24h, and skin irritation index should be not more than 0.4.
8) antibacterial ring test: according to the antibacterial ring test of Ministry of Public Health disinfection technology standard version 2.1.8.2 in 2002 item.
9) bactericidal property: according to Ministry of Public Health disinfection technology standard version 2.1.11.3.1 test in 2002 bactericidal property.
The testing result of table 1: embodiment 1:
The medical ultrasonic coupling agent that makes according to prescription of the present invention and preparation method with disinfecting and sterilizing functions, its character, pH, viscosity, the velocity of sound, acoustic characteristic impedance, acoustic attenuation, cytotoxicity, sensitization of skin, skin irritation, antibacterial ring test, bactericidal property are detected, and the result shows that testing result meets the requirements.
Embodiment 2:
1, feed intake: throwing total amount by formula proportion is the material of 1000g couplant, that is:
2, preparation method:
1) takes by weighing various compositions respectively according to recipe quantity;
2) carbomer 7.0g is joined in the 400g deionized water, and under water-bath 50-68 ℃, be stirred to dissolving fully, keep somewhere;
3) 20% poly hexamethylene biguanide 5.0g is dissolved in the 50.0g glycerol fully, keeps somewhere;
4) chloromycetin 2.5g is dissolved in the propylene glycol of 50g fully, keeps somewhere;
5) the 2g sodium hydroxide that takes by weighing is dissolved in the 100g deionized water fully, keeps somewhere
6) with step 3) and 4) add step 2 behind the mixed solution mix homogeneously that obtains) be stirred to evenly in the carbomer solution that obtains, add remaining deionized water then, and the slow sodium hydroxide solution that adds is stirred to evenly under stirring, makes into neutral gel, keep somewhere cool to room temperature, fill.
3, according to the detection method of embodiment 1 its detection is learnt: the medical ultrasonic coupling agent that makes according to prescription of the present invention and preparation method with disinfecting and sterilizing functions, its character, pH, viscosity, the velocity of sound, acoustic characteristic impedance, acoustic attenuation, cytotoxicity, sensitization of skin, skin irritation, antibacterial ring test, bactericidal property are detected, and the result shows that testing result meets the requirements.
Embodiment 3
1, feed intake: throwing total amount by formula proportion is the material of 1000g couplant, that is:
2, preparation method:
1) takes by weighing various compositions respectively according to recipe quantity;
2) carbomer 9.0 is joined in the 400g ionized water, and under water-bath 50-68 ℃, be stirred to dissolving fully, keep somewhere;
3) 20% poly hexamethylene biguanide 2.5g is dissolved in the 70.0g glycerol fully, keeps somewhere;
4) chloromycetin 2.0g is dissolved in the propylene glycol of 70g fully, keeps somewhere;
5) the 2.5g sodium hydroxide that takes by weighing is dissolved in the 100g ionized water fully, keeps somewhere
6) with step 3) and 4) add step 2 behind the mixed solution mix homogeneously that obtains) be stirred to evenly in the carbomer solution that obtains, add remaining deionized water then, and the slow sodium hydroxide solution that adds is stirred to evenly under stirring, makes into neutral gel, keep somewhere cool to room temperature, fill.
3, according to the detection method of embodiment 1 its detection is learnt: the medical ultrasonic coupling agent that makes according to prescription of the present invention and preparation method with disinfecting and sterilizing functions, its character, pH, viscosity, the velocity of sound, acoustic characteristic impedance, acoustic attenuation, cytotoxicity, sensitization of skin, skin irritation, antibacterial ring test, bactericidal property are detected, and the result shows that testing result meets the requirements.
Though, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (5)
1. a disinfection sterilizing type medical supersonic couplant is characterized in that, this couplant contains following active component: poly hexamethylene biguanide and chloromycetin.
2. couplant according to claim 1 is characterized in that, this couplant contains the active component of following percentage by weight: poly hexamethylene biguanide 0.02-0.05% and chloromycetin 0.20-0.30%.
3. couplant according to claim 2, it is characterized in that this couplant also contains following component in percentage by weight: carbomer 0.50-0.90%, glycerol 3.00-7.00%, propylene glycol 3.00-7.00%, sodium hydroxide 0.15-0.25% and deionized water 84.50-93.13%.
4. couplant according to claim 3, it is characterized in that, this couplant is made up of following component in percentage by weight: poly hexamethylene biguanide 0.02-0.05%, chloromycetin 0.20-0.30%, carbomer 0.50-0.90%, glycerol 3.00-6.00%, propylene glycol 3.00-6.00%, sodium hydroxide 0.15-0.25%, deionized water 86.50-93.13%.
5. a method for preparing each described couplant of claim 1-4 is characterized in that, this method may further comprise the steps:
1) carbomer is joined in the deionized water, and under water-bath 50-68 ℃, be stirred to dissolving fully, keep somewhere;
2) poly hexamethylene biguanide is dissolved in deionized water fully, joins then in the glycerol, keep somewhere;
3) chloromycetin is dissolved in the propylene glycol fully, keeps somewhere;
4) sodium hydroxide is dissolved in the deionized water fully, keeps somewhere;
5) with step 2), 3) add behind the mixed solution mix homogeneously of preparation in the carbomer solution of step 1) and be stirred to evenly, add remaining deionized water then, and slowly the dropping sodium solution stirring is extremely even under stirring, makes into neutral gel, keep somewhere cool to room temperature, fill.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768007A (en) * | 2012-10-26 | 2014-05-07 | 杭州元祺生物科技有限公司 | Medical disinfecting gel |
| CN112834615A (en) * | 2020-12-31 | 2021-05-25 | 山东医学高等专科学校 | Ultrasonic coupling agent for railway steel rail flaw detection and preparation method thereof |
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| CN1108956A (en) * | 1994-03-25 | 1995-09-27 | 刘卫国 | Coupling agent for medical ultrasonic diagnostic probe and its preparation |
| CN100542615C (en) * | 2007-01-10 | 2009-09-23 | 重庆安碧捷生物科技有限公司 | Has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof |
| CN101648026A (en) * | 2009-07-21 | 2010-02-17 | 戴新春 | Sterilizing type medical ultrasonic coupling agent and preparation method thereof |
| CN101698107A (en) * | 2009-09-03 | 2010-04-28 | 顾海 | Sterilizing medical ultrasonic coupling agent |
| CN101711879A (en) * | 2009-11-21 | 2010-05-26 | 日照众生医疗科技有限公司 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
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Patent Citations (5)
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| CN1108956A (en) * | 1994-03-25 | 1995-09-27 | 刘卫国 | Coupling agent for medical ultrasonic diagnostic probe and its preparation |
| CN100542615C (en) * | 2007-01-10 | 2009-09-23 | 重庆安碧捷生物科技有限公司 | Has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof |
| CN101648026A (en) * | 2009-07-21 | 2010-02-17 | 戴新春 | Sterilizing type medical ultrasonic coupling agent and preparation method thereof |
| CN101698107A (en) * | 2009-09-03 | 2010-04-28 | 顾海 | Sterilizing medical ultrasonic coupling agent |
| CN101711879A (en) * | 2009-11-21 | 2010-05-26 | 日照众生医疗科技有限公司 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768007A (en) * | 2012-10-26 | 2014-05-07 | 杭州元祺生物科技有限公司 | Medical disinfecting gel |
| CN112834615A (en) * | 2020-12-31 | 2021-05-25 | 山东医学高等专科学校 | Ultrasonic coupling agent for railway steel rail flaw detection and preparation method thereof |
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| CN102133409B (en) | 2012-07-11 |
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