CN101711879A - Sterilizing medical ultrasonic coupling agent and preparation method thereof - Google Patents
Sterilizing medical ultrasonic coupling agent and preparation method thereof Download PDFInfo
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- CN101711879A CN101711879A CN200910230493A CN200910230493A CN101711879A CN 101711879 A CN101711879 A CN 101711879A CN 200910230493 A CN200910230493 A CN 200910230493A CN 200910230493 A CN200910230493 A CN 200910230493A CN 101711879 A CN101711879 A CN 101711879A
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- barbaloin
- medical ultrasonic
- coupling agent
- triethanolamine
- ultrasonic coupling
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Abstract
The invention provides a sterilizing medical ultrasonic coupling agent and a preparation method thereof and belongs to the field of medical ultrasonic coupling agents. The sterilizing medical ultrasonic coupling agent is prepared by adding 6 grams of Carbomer, 6 grams of triethanolamine, 10 to 25 grams of glycerine and 0.075 to 0.15 grams of sterilizing agent in 1,000 milliliters of distilled water, wherein the sterilizing agent is barbaloin. Better using the sterilization action of the barbaloin, the sterilizing medical ultrasonic coupling agent can solve a common problem of ultrasonic coupling agent available in the current market for use in clinic ultrasonic diagnosis and treatment that cross infection is likely to occur as an ultrasonic probe or therapeutic head frequently contacts the detected or treated parts of different patients during the use of the ultrasonic coupling agent.
Description
Technical field
The present invention relates to a kind of medical ultrasonic coupling agent, relate in particular to a kind of medical ultrasonic coupling agent that uses when being used for skin and the ultrasound examination of tract mucosa with sterilizing function with treatment.
Background technology
Medical ultrasonic coupling agent is formulated by viscosity modifier, propylene glycol solvent and deionized water mostly in the prior art.This ultrasonic coupling agent is mainly used in the clinical ultrasound Clinics and Practices.But because ultrasonic probe or the frequent and different patients of treatment detect or therapentic part contacts in use is easy to generate cross infection, especially for tract mucosa ultrasound detection and treatment.Cross infection during for fear of ultrasound detection, be to adopt probe to be coated with behind the ultrasonic coupling agent reuse condom to entangle probe and detect at present mostly, insert in the tract for the ease of popping one's head in, the outer repaste ultrasonic coupling agent of the condom of being everlasting detects as lubricated method, this method operation is very loaded down with trivial details, and because condom entangles probe sound wave conduction and image definition is had considerable influence.
Summary of the invention
Technical assignment of the present invention is at not enough in the above-mentioned technology, and bactericidal medical ultrasonic couplant and preparation method thereof is provided.
The present invention addresses the above problem the technical scheme that is adopted: described bactericidal medical ultrasonic couplant comprises 6g carbomer, 6g triethanolamine, 10g-25g glycerol and 0.075g-0.15g antibacterial in every 1000ml distilled water.
Described antibacterial is a barbaloin.
Described bactericidal medical ultrasonic couplant, its preparation method is as follows:
(1) prepares raw material: water soluble polymer hydrogel, carbomer, glycerol, triethanolamine, barbaloin;
(2) get an amount of distilled water and slowly add carbomer limit edged and stir and treat that fully keep somewhere the dissolving back, begin to take shape carbomer solution;
(3) then, get an amount of triethanolamine adding barbaloin and be stirred to the dissolving indwelling, form the mixed liquor of triethanolamine and barbaloin;
(4) the carbomer solution after will dissolving under agitation slowly adds glycerol, slowly adds the triethanolamine that stirs and the mixed liquor of barbaloin then, makes it into gel.
The beneficial effect that the present invention can bring is:
1, the bactericidal medical ultrasonic couplant that the present invention stated has quick, permanent, stable sterilizing function, when having avoided clinical treatment, and the cross infection between the patient.
2, experiment showed, bactericidal medical ultrasonic couplant of the present invention through relevant ultrasonic unit area impedance, acoustic attenuation, sterilization dynamics, skin and mucous membrane irritation, toxicity, rubber corrosiveness etc., meet relevant every requirement and standard.
The specific embodiment
Below in conjunction with concrete effect the present invention is described in further details, but does not constitute the restriction any the present invention.
Bactericidal medical ultrasonic couplant, its constituent is: comprise 6g carbomer, 6g triethanolamine, 10g-25g glycerol and 0.075g-0.15g antibacterial in every 1000ml distilled water, wherein said antibacterial is a barbaloin.
Bactericidal medical ultrasonic couplant of the present invention, its preparation method is as follows:
(1) prepares raw material: water soluble polymer hydrogel, carbomer, glycerol, triethanolamine, barbaloin;
(2) get an amount of distilled water and slowly add carbomer limit edged and stir and treat that fully keep somewhere the dissolving back, begin to take shape carbomer solution;
(3) then, get an amount of triethanolamine adding barbaloin and be stirred to the dissolving indwelling, form the mixed liquor of triethanolamine and barbaloin;
(4) the carbomer solution after will dissolving under agitation slowly adds glycerol, slowly adds the triethanolamine that stirs and the mixed liquor of barbaloin then, makes it into gel.
To the bactericidal medical ultrasonic couplant of above-mentioned configuration, relevant velocity of ultrasonic sound, acoustic characteristic impedance, acoustic attenuation coefficient slope, viscosity, pH value etc. have been carried out a series of experiments, experimental technique and experimental result are as follows:
| Sequence number | Performance indications | Unit | Value |
| ??1 | The velocity of sound (35 ℃) | ??m/s | ??1520～1620 |
| ??2 | Acoustic characteristic impedance (35 ℃) | ??Pa·s/m | ??1.5×10 6～1.7×10 6 |
| ??3 | Acoustic attenuation coefficient slope (35 ℃) | ??dB/(cm·MH Z) | ??≤0.05 |
| ??4 | Viscosity (25 ℃) | ??Pa·s | ??25.9 |
| ??5 | PH value | ??- | ??6.2 |
Experimental technique and experimental result all meet corresponding national standards.
Simultaneously aspect stable, in the keeping life, under the normal storage condition, this bactericidal medical ultrasonic couplant layering should not occur, go mouldy and abnormal flavour; Aspect biocidal property, this bactericidal medical ultrasonic couplant is owing to having adopted barbaloin as antibacterial, and is inhibited to staphylococcus aureus, escherichia coli, bacillus pyocyaneus etc.; Aspect biocompatibility, in time of contact during less than 24 hours, the couplant cytotoxicity meets corresponding industry standard, and couplant does not have sensitization, non-stimulated to skin simultaneously.
Claims (3)
1. bactericidal medical ultrasonic couplant is characterized in that: comprise 6g carbomer, 6g triethanolamine, 10g-25g glycerol and 0.075g-0.15g antibacterial in every 1000ml distilled water.
2. bactericidal medical ultrasonic couplant according to claim 1 is characterized in that: described antibacterial is a barbaloin.
3. bactericidal medical ultrasonic couplant according to claim 1, its preparation method is as follows:
(1) prepares raw material: water soluble polymer hydrogel, carbomer, glycerol, triethanolamine, barbaloin;
(2) get an amount of distilled water and slowly add carbomer limit edged and stir and treat that fully keep somewhere the dissolving back, begin to take shape carbomer solution;
(3) then, get an amount of triethanolamine adding barbaloin and be stirred to the dissolving indwelling, form the mixed liquor of triethanolamine and barbaloin;
(4) the carbomer solution after will dissolving under agitation slowly adds glycerol, slowly adds the triethanolamine that stirs and the mixed liquor of barbaloin then, makes it into gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910230493A CN101711879A (en) | 2009-11-21 | 2009-11-21 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910230493A CN101711879A (en) | 2009-11-21 | 2009-11-21 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101711879A true CN101711879A (en) | 2010-05-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910230493A Pending CN101711879A (en) | 2009-11-21 | 2009-11-21 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN101711879A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991868A (en) * | 2010-11-01 | 2011-03-30 | 江苏永发医用设备有限公司 | Sterilizing, disinfecting and skin-moisturizing medical ultrasonic coupling agent and preparation method thereof |
| CN102133409A (en) * | 2011-03-18 | 2011-07-27 | 青岛明药堂医药科技开发有限公司 | Sterilizing type medical ultrasonic coupling agent and preparation method thereof |
| CN102688507A (en) * | 2011-03-23 | 2012-09-26 | 安徽深蓝医疗科技有限公司 | Disinfection and sterilization couplant and its preparation method |
| CN105148292A (en) * | 2015-08-21 | 2015-12-16 | 乔芳霞 | Medical ultrasonic coupling agent and preparation method thereof |
| CN105194697A (en) * | 2015-11-05 | 2015-12-30 | 济宁博联生物科技有限公司 | Medical ultrasonic coupling agent and preparation method thereof |
| CN106039330A (en) * | 2016-06-16 | 2016-10-26 | 吉林医药学院 | Antibacterial medical ultrasonic coupling agent containing traditional Chinese medicine ingredients and preparation method thereof |
| CN106039329A (en) * | 2016-05-20 | 2016-10-26 | 中山市天图精细化工有限公司 | Aerosol type medical ultrasonic coupling agent |
| CN107022161A (en) * | 2016-12-28 | 2017-08-08 | 长春吉原生物科技有限公司 | It is a kind of for hydrogel material of ultrasonic conducting and preparation method thereof |
| CN107753961A (en) * | 2017-12-06 | 2018-03-06 | 青岛大学附属医院 | A kind of Color Sonography ultrasonic coupling agent |
| CN109453399A (en) * | 2018-12-21 | 2019-03-12 | 山东朱氏堂医疗器械有限公司 | Medical ultrasonic coupling agent and its production method |
-
2009
- 2009-11-21 CN CN200910230493A patent/CN101711879A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991868A (en) * | 2010-11-01 | 2011-03-30 | 江苏永发医用设备有限公司 | Sterilizing, disinfecting and skin-moisturizing medical ultrasonic coupling agent and preparation method thereof |
| CN101991868B (en) * | 2010-11-01 | 2012-06-06 | 江苏永发医用设备有限公司 | Sterilizing, disinfecting and skin-moisturizing medical ultrasonic coupling agent and preparation method thereof |
| CN102133409A (en) * | 2011-03-18 | 2011-07-27 | 青岛明药堂医药科技开发有限公司 | Sterilizing type medical ultrasonic coupling agent and preparation method thereof |
| CN102133409B (en) * | 2011-03-18 | 2012-07-11 | 青岛明药堂医药科技开发有限公司 | Sterilizing type medical ultrasonic coupling agent and preparation method thereof |
| CN102688507A (en) * | 2011-03-23 | 2012-09-26 | 安徽深蓝医疗科技有限公司 | Disinfection and sterilization couplant and its preparation method |
| CN105148292A (en) * | 2015-08-21 | 2015-12-16 | 乔芳霞 | Medical ultrasonic coupling agent and preparation method thereof |
| CN105194697A (en) * | 2015-11-05 | 2015-12-30 | 济宁博联生物科技有限公司 | Medical ultrasonic coupling agent and preparation method thereof |
| CN105194697B (en) * | 2015-11-05 | 2018-07-27 | 济宁博联生物科技有限公司 | A kind of medical ultrasonic coupling agent and preparation method thereof |
| CN106039329A (en) * | 2016-05-20 | 2016-10-26 | 中山市天图精细化工有限公司 | Aerosol type medical ultrasonic coupling agent |
| CN106039330A (en) * | 2016-06-16 | 2016-10-26 | 吉林医药学院 | Antibacterial medical ultrasonic coupling agent containing traditional Chinese medicine ingredients and preparation method thereof |
| CN107022161A (en) * | 2016-12-28 | 2017-08-08 | 长春吉原生物科技有限公司 | It is a kind of for hydrogel material of ultrasonic conducting and preparation method thereof |
| CN107022161B (en) * | 2016-12-28 | 2019-10-22 | 长春吉原生物科技有限公司 | A kind of hydrogel material and preparation method thereof for ultrasonic conducting |
| CN107753961A (en) * | 2017-12-06 | 2018-03-06 | 青岛大学附属医院 | A kind of Color Sonography ultrasonic coupling agent |
| CN107753961B (en) * | 2017-12-06 | 2020-09-11 | 青岛大学附属医院 | Heart color ultrasound coupling agent |
| CN109453399A (en) * | 2018-12-21 | 2019-03-12 | 山东朱氏堂医疗器械有限公司 | Medical ultrasonic coupling agent and its production method |
| CN109453399B (en) * | 2018-12-21 | 2021-07-16 | 山东朱氏堂医疗器械有限公司 | Medical ultrasonic coupling agent and production method thereof |
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Open date: 20100526 |