CN105148292A - Medical ultrasonic coupling agent and preparation method thereof - Google Patents
Medical ultrasonic coupling agent and preparation method thereof Download PDFInfo
- Publication number
- CN105148292A CN105148292A CN201510514327.5A CN201510514327A CN105148292A CN 105148292 A CN105148292 A CN 105148292A CN 201510514327 A CN201510514327 A CN 201510514327A CN 105148292 A CN105148292 A CN 105148292A
- Authority
- CN
- China
- Prior art keywords
- coupling agent
- water
- ultrasonic coupling
- extract
- quintessence oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a medical ultrasonic coupling agent and belongs to the technical field of reagents for medical tests. The ultrasonic coupling agent is prepared from raw materials as follows: povidone iodine, oleic alcohol polyoxyethylene ether, konjac glucomannan, aloe gel, Chinese angelica essential oil, African marigold essential oil, heartleaf houttuynia herb essential oil, polyethylene glycol, potassium iodide, carbomer, triethanolamine, a Chinese angelica aqueous extract, a dandelion aqueous extract, a notoginseng aqueous extract, a liquorice aqueous extract and purified water. The ultrasonic coupling agent is free of cytotoxicity, irritation and sensitization to skin, free of bubbles, good in heat stability and good in biocompatibility, and cross infection during clinical ultrasonic tests is avoided; the ultrasonic coupling agent is good in lubrication property and easy to expand, has sterilization and anti-inflammatory functions, can soften, moisten and smoothen the skin and has effects of promoting blood circulation, removing blood stasis, relieving pain and removing swellings; the ultrasonic coupling agent has a good coupling function and is significant in transmission effect and clear in ultrasonic imaging.
Description
Technical field
The invention belongs to medical inspection reagent technique field, specifically a kind of medical ultrasonic coupling agent and preparation method thereof.
Background technology
Medical ultrasonic coupling agent is that a kind of filling of needing to use in ultrasonic diagnosis and therapeutic process or be coated on is popped one's head between radiating surface and human epidermal, mucosa, in order to the ultrasonic neutral medium of transmitted acoustic pulse.Ultrasonic coupling agent plays a part to determine good and bad and even success or failure in ultrasonic diagnosis and treatment operation, in clinical practice, not only play a part entrant sound medium, also play a part lubricant, be concerned about also is not only its acoustic characteristic clinically, also has safety and effectiveness target, wherein, effectiveness is mainly conceived to entrant sound effect, and safety is mainly conceived to the impact on tissue and the defence to cross infection.
Existing medical ultrasonic coupling agent is mainly with hydroxyethyl-cellulose, hydroxypropyl cellulose, one among carbomer is as viscosity modifier, be equipped with propylene glycol solvent again and deionized water is formed by combining, or be equipped with disinfection sanitizer composition again, its effect is when clinical ultrasonic diagnosis or ultrasonic therapeutic, coupling is set up between sound head and human body, enable sound head the ultrasound wave sent out enter human body smoothly, to obtain reliable checkout and diagnosis image, or reach effective therapeutic purposes, but due to the intermiscibility problem of antibacterial and aqueous high molecular gel preparation cannot be solved, antibacterial type product is caused to lump and muddiness, and antibacterial effect is also not ideal enough, also may can produce certain corrosion and stimulation to the patient skin of being checked in clinical practice.
Along with the modernization development of China's herbal industry, there is the medical ultrasonic coupling agent that medicinal herb components is made, as patent of invention CN104127892A, CN103961327A, CN103751812B, CN103341184B etc., having much room for improvement in gelation and compatibility aspect of this type of medical ultrasonic coupling agent, though it is not there is effect that is antibacterial and treatment, remarkable.
Povidone iodine be a kind of novel efficient, wide spectrum, zest are little, have no side effect, noresidue, without Drug resistance antibacterial.It has stronger killing action to staphylococcus aureus, bacillus pyocyaneus, hepatitis B virus, HIV (human immunodeficiency virus), trichomonas vaginitis, spore etc., almost can kill antibacterial common clinically.The product or the technology that use povidone iodine to make gel is had in prior art, as patent of invention CN102657600A discloses a kind of povidone iodine gel for veterinary use and preparation technology, but this gellike is applied few in ultrasound medicine, entrant sound effect and ultra sonic imaging effect relatively poor.
Summary of the invention
The present invention is directed to the above-mentioned defect that prior art exists, provide that a kind of safety is high, antibiotic property good, the medical ultrasonic coupling agent of entrant sound Be very effective, imaging clearly, additionally provide the preparation method of this medical ultrasonic coupling agent.
To achieve these goals, the present invention is achieved by the following technical solutions:
A kind of medical ultrasonic coupling agent, be made up of following raw materials by weight: povidone iodine 0.1-1%, oleic alcohol polyoxyethylene ether 0.02-0.5%, Konjac glucomannan 0.05-0.5%, Aloe glue 0.05-0.65%, angelica essential oil 0.05-0.1%, Flos Tagetis Erectae quintessence oil 0.05-0.15%, Herba Houttuyniae quintessence oil 0.05-0.1%, Polyethylene Glycol 2-5%, potassium iodide 0.01-0.1%, carbomer 0.1-2%, triethanolamine 0.05-1.55%, Radix Angelicae Sinensis water extract 0.5-1%, Herba Taraxaci water extract 0.5-1%, pseudo-ginseng water extract 0.5-1%, liquorice beverage extract 0.5-1%, surplus purified water.
The preparation method of described medical ultrasonic coupling agent, comprises the following steps:
(1) povidone iodine, potassium iodide are added in appropriate purified water, fully dissolve, obtain water solution A; Radix Angelicae Sinensis water extract, Herba Taraxaci water extract, pseudo-ginseng water extract, liquorice beverage extract are added in appropriate purified water, fully dissolves, obtain aqueous solution B; Konjac glucomannan, Aloe glue are added in appropriate purified water, fully dissolves, obtain water-soluble glue C; By angelica essential oil, Flos Tagetis Erectae quintessence oil, the mixing of Herba Houttuyniae quintessence oil, obtain being in harmonious proportion quintessence oil;
(2) add in appropriate purified water by carbomer, Polyethylene Glycol, oleic alcohol polyoxyethylene ether, heating, stirring make it dissolve, and obtain solution D;
(3) in solution D, add mediation quintessence oil, water-soluble glue C, aqueous solution B, water solution A successively, stir, continue to add triethanolamine in the mixed liquor obtained, regulate the pH value of mixed liquor to being neutrality, obtain ultrasonic coupling agent gel, remove bubble under vacuum decompression, obtain product.
Advantageous Effects of the present invention: the present invention to skin no cytotoxicity, non-stimulated, without sensitization, bubble-free, Heat stability is good, good biocompatibility, avoids ultrasonographic cross infection clinically; Greasy property is good, is easy to launch, and has sterilizing, antiinflammatory action, and the soft and moist fine skin of energy, has blood circulation promoting and blood stasis dispelling, alleviating pain and detumescence effect; Have good coupling, entrant sound Be very effective, ultra sonic imaging is clear.
Detailed description of the invention
Carry out describing in detail better to set forth the present invention below in conjunction with embodiment, but do not form scope restriction.
Embodiment 1
A kind of medical ultrasonic coupling agent, is made up of following raw materials by weight: povidone iodine 0.1%, oleic alcohol polyoxyethylene ether 0.02%, Konjac glucomannan 0.05%, Aloe glue 0.05%, angelica essential oil 0.05%, Flos Tagetis Erectae quintessence oil 0.05%, Herba Houttuyniae quintessence oil 0.05%, Polyethylene Glycol 2%, potassium iodide 0.01%, carbomer 0.1%, triethanolamine 0.05%, Radix Angelicae Sinensis water extract 0.5%, Herba Taraxaci water extract 0.5%, pseudo-ginseng water extract 0.5%, liquorice beverage extract 0.5%, purified water.
The preparation method of described medical ultrasonic coupling agent, comprises the following steps:
(1) povidone iodine, potassium iodide are added in appropriate purified water, fully dissolve, obtain water solution A; Radix Angelicae Sinensis water extract, Herba Taraxaci water extract, pseudo-ginseng water extract, liquorice beverage extract are added in appropriate purified water, fully dissolves, obtain aqueous solution B; Konjac glucomannan, Aloe glue are added in appropriate purified water, fully dissolves, obtain water-soluble glue C; By angelica essential oil, Flos Tagetis Erectae quintessence oil, the mixing of Herba Houttuyniae quintessence oil, obtain being in harmonious proportion quintessence oil;
(2) add in appropriate purified water by carbomer, Polyethylene Glycol, oleic alcohol polyoxyethylene ether, heating, stirring make it dissolve, and obtain solution D;
(3) in solution D, add mediation quintessence oil, water-soluble glue C, aqueous solution B, water solution A successively, stir, continue to add triethanolamine in the mixed liquor obtained, regulate the pH value of mixed liquor to being neutrality, obtain ultrasonic coupling agent gel, remove bubble under vacuum decompression, obtain product.
Embodiment 2
A kind of medical ultrasonic coupling agent, is made up of following raw materials by weight: povidone iodine 0.5%, oleic alcohol polyoxyethylene ether 0.25%, Konjac glucomannan 0.23%, Aloe glue 0.35%, angelica essential oil 0.75%, Flos Tagetis Erectae quintessence oil 0.75%, Herba Houttuyniae quintessence oil 0.77%, Polyethylene Glycol 2.5%, potassium iodide 0.06%, carbomer 1%, triethanolamine 0.8%, Radix Angelicae Sinensis water extract 0.75%, Herba Taraxaci water extract 0.75%, pseudo-ginseng water extract 0.75%, liquorice beverage extract 0.75%, purified water.
The preparation method of the medical ultrasonic coupling agent described in the present embodiment is with embodiment 1.
Embodiment 3
A kind of medical ultrasonic coupling agent, is made up of following raw materials by weight: povidone iodine 1%, oleic alcohol polyoxyethylene ether 0.5%, Konjac glucomannan 0.5%, Aloe glue 0.65%, angelica essential oil 0.1%, Flos Tagetis Erectae quintessence oil 0.15%, Herba Houttuyniae quintessence oil 0.1%, Polyethylene Glycol 5%, potassium iodide 0.1%, carbomer 2%, triethanolamine 1.55%, Radix Angelicae Sinensis water extract 1%, Herba Taraxaci water extract 1%, pseudo-ginseng water extract 1%, liquorice beverage extract 1%, purified water.
The preparation method of the medical ultrasonic coupling agent described in the present embodiment is with embodiment 1.
Claims (2)
1. a medical ultrasonic coupling agent, it is characterized in that: be made up of following raw materials by weight: povidone iodine 0.1-1%, oleic alcohol polyoxyethylene ether 0.02-0.5%, Konjac glucomannan 0.05-0.5%, Aloe glue 0.05-0.65%, angelica essential oil 0.05-0.1%, Flos Tagetis Erectae quintessence oil 0.05-0.15%, Herba Houttuyniae quintessence oil 0.05-0.1%, Polyethylene Glycol 2-5%, potassium iodide 0.01-0.1%, carbomer 0.1-2%, triethanolamine 0.05-1.55%, Radix Angelicae Sinensis water extract 0.5-1%, Herba Taraxaci water extract 0.5-1%, pseudo-ginseng water extract 0.5-1%, liquorice beverage extract 0.5-1%, surplus purified water.
2. the preparation method of medical ultrasonic coupling agent according to claim 1, is characterized in that: comprise the following steps:
(1) povidone iodine, potassium iodide are added in appropriate purified water, fully dissolve, obtain water solution A; Radix Angelicae Sinensis water extract, Herba Taraxaci water extract, pseudo-ginseng water extract, liquorice beverage extract are added in appropriate purified water, fully dissolves, obtain aqueous solution B; Konjac glucomannan, Aloe glue are added in appropriate purified water, fully dissolves, obtain water-soluble glue C; By angelica essential oil, Flos Tagetis Erectae quintessence oil, the mixing of Herba Houttuyniae quintessence oil, obtain being in harmonious proportion quintessence oil;
(2) add in appropriate purified water by carbomer, Polyethylene Glycol, oleic alcohol polyoxyethylene ether, heating, stirring make it dissolve, and obtain solution D;
(3) in solution D, add mediation quintessence oil, water-soluble glue C, aqueous solution B, water solution A successively, stir, continue to add triethanolamine in the mixed liquor obtained, regulate the pH value of mixed liquor to being neutrality, obtain ultrasonic coupling agent gel, remove bubble under vacuum decompression, obtain product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510514327.5A CN105148292A (en) | 2015-08-21 | 2015-08-21 | Medical ultrasonic coupling agent and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510514327.5A CN105148292A (en) | 2015-08-21 | 2015-08-21 | Medical ultrasonic coupling agent and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105148292A true CN105148292A (en) | 2015-12-16 |
Family
ID=54789542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510514327.5A Pending CN105148292A (en) | 2015-08-21 | 2015-08-21 | Medical ultrasonic coupling agent and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105148292A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105903040A (en) * | 2016-06-01 | 2016-08-31 | 湖南凯利医疗科技有限公司 | Blood circulation promoting and stasis removing ultrasonic coupling agent |
CN107496942A (en) * | 2017-09-20 | 2017-12-22 | 贺海霞 | A kind of medical disinfecting type ultrasonic coupling agent and preparation method thereof |
CN112891567A (en) * | 2021-01-29 | 2021-06-04 | 陈卫东 | Emulsifying agent |
CN113679856A (en) * | 2021-08-11 | 2021-11-23 | 中山市天图精细化工有限公司 | Aerosol type medical ultrasonic coupling agent |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4886068A (en) * | 1985-07-29 | 1989-12-12 | Kabushiki Kaisha Toshiba | Ultrasonic coupling agent |
CN1374133A (en) * | 2002-03-21 | 2002-10-16 | 黎国梓 | B-mode ultrasound coupling agent and its prepn |
CN101612408A (en) * | 2009-07-24 | 2009-12-30 | 赵敬民 | B ultrasonic couplant and preparation method |
CN101711879A (en) * | 2009-11-21 | 2010-05-26 | 日照众生医疗科技有限公司 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
CN103961327A (en) * | 2013-01-30 | 2014-08-06 | 中国石油天然气股份有限公司 | Medical ultrasonic coupling agent |
CN104189927A (en) * | 2014-09-02 | 2014-12-10 | 延良海 | Ultrasonic coupling agent |
-
2015
- 2015-08-21 CN CN201510514327.5A patent/CN105148292A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4886068A (en) * | 1985-07-29 | 1989-12-12 | Kabushiki Kaisha Toshiba | Ultrasonic coupling agent |
CN1374133A (en) * | 2002-03-21 | 2002-10-16 | 黎国梓 | B-mode ultrasound coupling agent and its prepn |
CN101612408A (en) * | 2009-07-24 | 2009-12-30 | 赵敬民 | B ultrasonic couplant and preparation method |
CN101711879A (en) * | 2009-11-21 | 2010-05-26 | 日照众生医疗科技有限公司 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
CN103961327A (en) * | 2013-01-30 | 2014-08-06 | 中国石油天然气股份有限公司 | Medical ultrasonic coupling agent |
CN104189927A (en) * | 2014-09-02 | 2014-12-10 | 延良海 | Ultrasonic coupling agent |
Non-Patent Citations (1)
Title |
---|
袁国正: "复方中草药在超声波药物耦合剂中的抗菌效果", 《广东工业大学学报》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105903040A (en) * | 2016-06-01 | 2016-08-31 | 湖南凯利医疗科技有限公司 | Blood circulation promoting and stasis removing ultrasonic coupling agent |
CN107496942A (en) * | 2017-09-20 | 2017-12-22 | 贺海霞 | A kind of medical disinfecting type ultrasonic coupling agent and preparation method thereof |
CN112891567A (en) * | 2021-01-29 | 2021-06-04 | 陈卫东 | Emulsifying agent |
CN113679856A (en) * | 2021-08-11 | 2021-11-23 | 中山市天图精细化工有限公司 | Aerosol type medical ultrasonic coupling agent |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103751812B (en) | Ultrasonic couplant and preparation method thereof | |
CN103341184B (en) | Ultrasonic coupling agent and preparation method thereof | |
CN105148292A (en) | Medical ultrasonic coupling agent and preparation method thereof | |
CN108778304A (en) | For preventing and/or treating oral cavity, the upper respiratory tract and the composition of esophagus disease | |
WO2011023013A1 (en) | Medicine for dissolving and eliminating wart and excrescence consisting of protein and its uses | |
CN103977432A (en) | Ultrasonic couplant for heart color Doppler ultrasound | |
CN106540281A (en) | B ultrasonic couplant and its preparation technology | |
CN110051773A (en) | A kind of gel and its preparation method that containing Camellia nitidissima there is antibacterial to repair cavity inflammation | |
CN103191418B (en) | Buccal patch for treating dental ulcer by combination of internal and external treatments | |
CN101474284A (en) | External use medicament for treating fungal dermatopathy | |
RU2450816C2 (en) | Compositions of hyaluronic acid salt for epithelial damages | |
CN103239731B (en) | Edible buccal patch for treating dental ulcer | |
CN107158412A (en) | B ultrasound couplant and preparation method thereof | |
CN105343904A (en) | Medical color doppler ultrasound coupling agent and preparation method thereof | |
CN107233584A (en) | A kind of couplant and preparation method thereof | |
CN112007101A (en) | Clove antibacterial liquid | |
CN105079830A (en) | Coupling agent for ultrasonic and preparation method of coupling agent | |
CN105311600A (en) | Medical gel having sterilizing and disinfecting functions | |
CN110302228A (en) | A kind of biological agent that treating hemorrhoid and its application | |
CN108030934A (en) | A kind of aqua type medical ultrasonic coupling agent and preparation method thereof and application method | |
CN107334782A (en) | A kind of inhibiting bacteria and diminishing inflammation agent and its preparation method and application | |
KR100906735B1 (en) | Lotion composition for transmitting ultrasonic wave | |
CN105903040A (en) | Blood circulation promoting and stasis removing ultrasonic coupling agent | |
CN106110337A (en) | A kind of B ultrasonic couplant and preparation method | |
CN105381476A (en) | Ultrasonic coupling agent for color ultrasonography and preparation method of ultrasonic coupling agent |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151216 |