CN106110337A

CN106110337A - A kind of B ultrasonic couplant and preparation method

Info

Publication number: CN106110337A
Application number: CN201610465348.7A
Authority: CN
Inventors: 孙奉生
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-06-16
Filing date: 2016-06-16
Publication date: 2016-11-16

Abstract

The invention discloses a kind of B ultrasonic couplant and preparation method, belong to the field of Chinese medicines；The raw material of couplant effective ingredient of the present invention consists of: ligustrum sinense, Folium Pini, Radix seu Folium Alchorneae trewioidis, Herba leucadis zeylanicae, Radix Sophorae Flavescentis, Anaer Cygnoides domestica Brisson, attached column flower, Herba Blumeae Lacerae, Rhizoma Coptidis, Aloe, Herb Pararuelliae delavayanae, Galla Chinensis, Radix clerodendri fragrantis (Radix Clerodendri Philippini), Folium Allii fistulosi, Herba Lysimachiae Grammicae and Rhizoma Chuanxiong；Selected by couplant of the present invention, medical material compatibility is suitable, meets Chinese medicine and modern medicine is theoretical, have bactericidal antiphlogistic, effect of reducing swelling and alleviating pain, greasy property is good, easily launches, soft and moist exquisiteness, non-stimulated to human body, have no side effect, according to clinical verification, imaging effect is good, image resolution ratio is high, has promoting healing effect, is suitable to clinical application.

Description

A kind of B ultrasonic couplant and preparation method

Art

The present invention relates to the field of Chinese medicines, particularly relate to a kind of B ultrasonic couplant and preparation method.

Background technology

B ultrasonic is an emerging subject, is indispensable diagnostic method in current clinical medicine.B ultrasonic can be clearly Show the various section pictures of each internal organs and peripheral organs, owing to image is imbued with entity sense, close to the real structure dissected, so Apply and ultrasonic can clarify a diagnosis in early days.During ultrasound diagnosis, the air between probe and patient skin will hinder the incoming people of ultrasound wave Body, for obtaining high-quality image, needs fluidity transmitting medium to connect probe and patient body-surface, and this medium couples exactly Agent.

Couplant is a kind of easy-to-use product being made up of a new generation's aqueous high molecular gel.PH value is neutral, can improve aobvious Show definition, excellent；Painting need not be repeated put on the skin, be conducive to saving Diagnostic Time.The purpose using couplant is filling contact Slight void between face, does not make these interstitial micro-airs affect ultrasonic penetrating；Next to that by couplant " mistake Cross " effect, make the acoustic impedance difference between probe and skin reduce, thus reduce the ultrasonic energy reflection loss at this interface.Separately Outward, also act as the effect of lubrication, reduce the friction between probe face and skin, make probe to slide flexibly and detect.Couplant Quality closely related with the Quality of acoustical image graphic obtained.Couplant should have human non-toxic harmless, and sterilizing power is strong, viscous Consistence is suitable, and without greasy, greasy property is good, it is easy to launch, corrosion-free to ultrasonic probe, non-stimulated to skin, anti-without allergy Should, and easily wipe, there is good thixotropy and do not trickle, the feature of good stability etc..

Existing coupling agent for medical use is widely used to hospital, for skin, tract mucosa ultrasound examination and treatment Intermediary's medium, each many employings of hospital clinical ultrasound diagnosis are based on the coupling of sodium carboxymethyl cellulose, methyl para hydroxy benzoic acid etc. Mixture, although there is certain coupling effect, but its anti-microbial property is poor, partly sterilization type being mainly composed of of medical ultrasonic coupling agent Learn complex, in clinical practice, the patient skin being checked can be produced certain corrosion and stimulation.

Need the excellent couplant of the features such as a kind of antibiotic property is good, corrosion-free, non-stimulated for this, check and treatment to improve Effect, this has highly important clinical meaning for ultrasound diagnosis.

Summary of the invention

The invention provides a kind of B ultrasonic couplant and preparation method, medical material compatibility selected by couplant of the present invention is suitable, meets Chinese medicine and modern medicine are theoretical, have bactericidal antiphlogistic, effect of reducing swelling and alleviating pain, and greasy property is good, easily launches, soft and moist exquisiteness, Non-stimulated to human body, have no side effect, according to clinical verification, imaging effect is good, and image resolution ratio is high, has promoting healing effect, suitable In clinical application.

For achieving the above object, technical scheme is implemented as follows:

A kind of B ultrasonic couplant, raw material composition and the parts by weight of making described couplant effective ingredient are:

Make described couplant effective ingredient raw material composition and parts by weight be:

The preparation method of a kind of B ultrasonic couplant, comprises the following steps that:

(1) ligustrum sinense, Anaer Cygnoides domestica Brisson, Herb Pararuelliae delavayanae, Galla Chinensis, Radix clerodendri fragrantis (Radix Clerodendri Philippini) and Herba Lysimachiae Grammicae are gone the removal of impurity, clean, put into container In, add 6 times amount distilled water, soak 2～3 hours, then add 5 times amount distilled water, decoct 2 hours, extract decoction liquor；Add 4 times amount distilled water, decoct 1.5 hours, extract decoction liquor, finally merge the decoction liquor extracted 2 times, filter, obtain filtrate, standby；

(2) Folium Pini, Radix seu Folium Alchorneae trewioidis and attached column have been spent the removal of impurity, cleaned and dry, smash to pieces in being placed in mortar, obtained 120 mesh Fine powder, standby；

(3) Herba leucadis zeylanicae, Herba Blumeae Lacerae, Aloe and Folium Allii fistulosi are gone the removal of impurity, clean, be placed in strand juice in container, filter, obtain filter Juice, standby；

(4) Radix Sophorae Flavescentis, Rhizoma Coptidis and Rhizoma Chuanxiong are gone the removal of impurity, clean section, add fresh ginger juice and boiled water, mix thoroughly, treat juice Frying to surface buff degree of being with slow fire after exhaustion, taking-up cools, and smashs to pieces in being placed in mortar, obtains the fine powder of 140 mesh, standby With；

(5) by the filtrate of step (1) gained, step (2), the fine powder of step (4) gained, the filtered juice of step (3) gained is mixed Close, and add Lac Bovis seu Bubali and glycerol, stirring and dissolving uniformly after, be slowly added dropwise the NaOH solution of 1mol/L, regulation pH value to 7.0, after Standing 24 hours, extract and filter, concentration is that at 60 DEG C, relative density is the thick paste of 1.11～1.13, canning sealing, is described B ultrasonic couplant.

The property of medicine of Chinese medicine used by the present invention is as follows:

Ligustrum sinense: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, bacteriostasis and sterilization, reducing swelling and alleviating pain, putrefaction-removing granulation-promoting.Pass for acute icteric Metachromia hepatitis, dysentery, cough due to lung-heat, traumatic injury, traumatic infection, burn and scald, the surgical infection disease such as sore swollen toxin.Modern Medical research confirms, ligustrum sinense leaf is to staphylococcus aureus, Bacillus typhi, paratyphoid bacillus A, bacillus pyocyaneus, large intestine bar Bacterium, bacterium flexneri, pneumobacillus have extremely strong antibacterial action.

Folium Pini: bitter in the mouth, warm in nature；GUIXIN, spleen channel.Dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching.For rheumatism flaccidity syndrome and arthralgia syndrome, traumatic injury, insomnia Edema, eczema scabies, and epidemic encephalitis, influenza, ancylostomiasis can be prevented and treated." the SHENGCAO property of medicine standby will " carries: " kill, solid carbon dioxide, antipruritic, bury mouth (the conjunction open sore part).Wash chancre, control scabies.”

Radix seu Folium Alchorneae trewioidis: sweet in the mouth, cool in nature；Return bladder, large intestine, lung meridian.Clearing away heat-damp and promoting diuresis, dissipating blood stasis stops blooding.For dysentery, urine is not Profit, hematuria, lithangiuria, red collapses leucorrhea, lumbago and skelalgia, treating swelling and pain by traumatic injury, traumatic hemorrhage, urticaria, eczema." Guangxi Chinese herbal medicine " Carry: " removing toxic substances, dehumidifying, hemostasis, control dysentery, lithangiuria or inflammation, metrorrhagia, leucorrhea, rubella, scabies, tinea pedis, caries pain, wound Hemorrhage.”

Herba leucadis zeylanicae: bitter in the mouth, pungent, warm in nature.Expelling wind and cold, preventing phlegm from forming and stopping coughing.For headache due to common cold, toothache is coughed, pharyngolaryngitis, and hundred Day is coughed, bronchial asthma." register planted by Guangxi medicine " carries: " control scabies, dermatosis.”

Radix Sophorae Flavescentis: bitter in the mouth, cold in nature；GUIXIN, liver, stomach, large intestine, bladder warp.Heat clearing and damp drying, parasite killing diuresis.For hematodiarrhoea, just Blood, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema eczema, skin pruritus, scabies leprosy." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " removing heat from blood, Relieving heat toxin, mange, impetigo poison.Treat skin pruritus, blood tinea corporis skin ulcer, naughty white scales, discharging fresh blood stool, have blood in stool.Pathogenic wind expelling, detumescence poison, Expectorant poison." modern medicine study confirmation, Radix Sophorae Flavescentis has inhibitory action to tubercule bacillus.

Anaer Cygnoides domestica Brisson: sweet in the mouth, cool in nature；GUIXIN, small intestine meridian.Profit skin, removing toxic substances is swollen.It is chapped from the cold for skin, deaf ear, dysphagic Regurgitation, drug intoxication, carbuncle scabies." Bencao Congxin " carries: " dispels the wind, moisturizes.”

Attached column flower: acrid in the mouth, micro-hardship, cool in nature.Heat-clearing and toxic substances removing, dampness removing is antipruritic, reducing swelling and alleviating pain.For dysentery skin infection, eczema, skin Skin pruritus, caterpillar stabs, traumatic injury.

Herba Blumeae Lacerae: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For tonsillitis, stomatitis, gingival abscess is popular Property parotitis, infantile pneumonia, ulcerative carbuncle toxic swelling, skin pruritus." Yunnan Chinese herbal medicine " carries: " heat-clearing and toxic substances removing, antiinflammatory.Control infantile pneumonia, Tonsillitis, parotitis, stomatitis, innominate toxic swelling, skin pruritus.”

Rhizoma Coptidis: bitter in the mouth, cold in nature；GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot painful abdominal mass Expiring, vomiting acid regurgitation, dysentery jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, and conjunctival congestion is had a toothache, and quenches one's thirst, carbuncle furuncle Skin ulcer, eczema eczema, auditory meatus is suppurated." Japan hanako materia medica " carries: " control five kinds of strain and seven kinds of impairment, QI invigorating, only cardiac and abdominal pain.Palpitation with fear agitation, moistens the heart Lung, puts on flesh, hemostasis；And skin ulcer scabies, night sweat, the hot disease of sky row；It is ball that Gaster Sus domestica steams, and controls children's's infantile malnutrition gas.”

Aloe: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, relieving constipation parasite killing.For constipation with heat retention, women's amenorrhea, pediatric epilepsy scared, infantile malnutrition with fever Malnutrition due to parasitic infestation, tinea skin ulcer hemorrhoid complicated by anal fistula, atrophic rhinitis, scrofula.Modern medicine study confirms, Aloe is to epidermophyton inguinale, red skin The dermatophytess such as tinea bacterium, star nocardia have inhibitory action in various degree, Folium Aloe juice to make the coagel containing polysaccharide Preparation, can cure skin or other tissue injury and burn.

Herb Pararuelliae delavayanae: sweet in the mouth, light, property is put down；Return lung, spleen channel.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For pneumonia, tonsillitis, the cheek Adenitis, scrofula, abscess sore, fracture, traumatic infection." Yunnan Chinese herbal medicine " carries: " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control fracture, drench Fawn on tuberculosis, parotitis, traumatic hemorrhage.”

Galla Chinensis: sour in the mouth, puckery, cold in nature；Return lung, large intestine, kidney channel.Astringing the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating stops blooding, and removing dampness is held back Skin ulcer.For chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, night sweat, quenching one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, skin is wet Rotten." detailed outline " carries: " pathogenic fire reducing of astringing the lung, reduce phlegm drink, and cough-relieving is coughed, and quenches one's thirst, night sweat, vomiting, loses blood, chronic dysentery, jaundice, cardiac and abdominal pain, children's Night cry, controls eye red wet rotten, detumescence poison, sore throat, holds back routed skin ulcer, incised wound, receives under proctoptosis, sub-intestinal pendant.”

Radix clerodendri fragrantis (Radix Clerodendri Philippini): bitter in the mouth, pungent, warm in nature；GUIXIN, spleen, kidney channel.Wind-damp dispelling, strengthing aitch bone, promoting blood circulation and detumescence.For pathogenic wind-warm arthralgia pain, Tinea pedis edema, osteopatia sprain, blood stasis swells and ache, hemorrhoid proctoptosis, chronic osteomyelitis." conventional Chinese herbal medicine handbook " carries: " expelling wind and activating blood circulation, Detumescence blood pressure lowering.”

Folium Allii fistulosi: acrid in the mouth, warm in nature.Wind-damp dispelling, diaphoresis of dispeling the wind, removing toxic substances and promoting subsidence of swelling.For cold, headache nasal obstruction, fever of the body without Antiperspirant, apoplexy, the edema of the face, sore, carbuncle and painful swelling, traumatic injuries." Treatise on Dietetic Therapy " carries: " appearance is floated for main typhoid fever high fever, perspiration apoplexy Swollen, joint headache.”

Herba Lysimachiae Grammicae: bitter in the mouth, acid, cool in nature.Stopping blooding antipyretic, vital energy regualting and blood circulation-promoting, detumescence of drawing out pus by applying a plaster to the affected part, arresting convulsion is only jerked.For traumatic injury, Innominate toxic swelling, injury by sword or axe." Guizhou folk medicine " carries: " stopping blooding antipyretic, vital energy regualting and blood circulation-promoting, detumescence of drawing out pus by applying a plaster to the affected part, arresting convulsion is only jerked.”

Rhizoma Chuanxiong: acrid in the mouth, warm in nature；Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea pain Warp, lump in the abdomen stomachache, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia." not Lu " carries: " except cold dynamic in brain, on face, urticaria goes Come, mesh lacrimation, profuse nasal discharge and spittle, before we notice it as the most liquor-saturated, all cold gas, trusted subordinate's heavily fortified point pain, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold.”

The present invention compared with prior art, has the advantages that

Selected by couplant of the present invention, medical material compatibility is suitable, meets Chinese medicine and modern medicine is theoretical, have bactericidal antiphlogistic, disappear Effect of swollen pain relieving, greasy property is good, easily launches, and soft and moist exquisiteness is non-stimulated to human body, has no side effect, and according to clinical verification, becomes As effective, image resolution ratio is high, has promoting healing effect, is suitable to clinical application.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material of couplant effective ingredient of the present invention forms and weight is:

The processing step of couplant preparation method of the present invention is:

Usage and dosage: external, holds couplant in bottle from couplant before ultrasound diagnosis and extrudes, be applied in ultrasound diagnosis portion Position, health is checked by slip ultrasonic probe.

Embodiment 2

The couplant preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.

Embodiment 3

Embodiment 4

Clinical data:

1, case selection:

Selecting my institute or outer court need to do the patient 476 example clinical observation of B ultrasonic, patient is randomly divided into two groups, experimental group 238 Example, wherein male 110 example, women 128 example, age 5～77 years old, 49 years old mean age, the course of disease 2 months～6 years, average 3 years.Right According to organizing 238 examples, wherein male 119 example, women 119 example, age 7～80 years old, 50 years old mean age, the course of disease 1 month～4 years, flat Equal 2 years.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.

2, medicament selection:

Carrying out during B ultrasonic before inspection, experimental group patient uses B ultrasonic couplant of the present invention, and matched group uses the medical coupling of MIBO Agent, both are strictly used by operation instructions requirement.

3, the comparison is as follows table:

Result above shows, in experimental group, the using effect of B ultrasonic couplant of the present invention is apparently higher than matched group.

Model case is illustrated:

1, king's ××, female, 6 years old, child, people from Wuhan, Hubei.The careless abdominal part of patient is wound, and need to do ultrasound diagnosis, but self skin Skin is responsive type, and the couplant used for B ultrasonic process exists severe allergic reaction.After using B ultrasonic couplant of the present invention, skin And health has no rejection, and imaging definition is high.

2, bag ××, man, 13 years old, student, Pekinese.Owing to patient is to pollen hypersensitivity, cause whole skin red and swollen, scabies Itching, often there is stomachache, the symptoms such as vomiting of exerting one's utmost effort in recent patient, and ultrasound diagnosis is done by my institute then, uses B ultrasonic couplant of the present invention After, at skin allergy, no abnormality seen reacts, and skin is gradually fully recovered.

3, Korea Spro's ××, female, 22 years old, anemia of pregnant woman, people from Changchun, Jilin.Anemia of pregnant woman bumps to health due to imprudence, and skin is damaged Wound.Originally couplant used during its ultrasound diagnosis is caused patient wound to infect by doctor, rear doctor give anemia of pregnant woman change use this Bright B ultrasonic couplant, without deteriorating at skin infection, and gradually heals.

4, Xue's ××, female, 28 years old, anemia of pregnant woman, people from Suqian, Jiangsu.Anemia of pregnant woman because couplant is had anaphylaxis,

After producing inspection, the equal pruritus of skin is unbearably every time, and rear doctor is used for B ultrasonic couplant, and pruritis substantially alleviates, it After be continuing with B ultrasonic couplant and check, transference cure, follow up a case by regular visits to not recur.

5, Fu's ××, man, 35 years old, driver, people from Changsha.Pain around a root bone below patient's upper right abdomen, and can put It is mapped to shoulder and back, is often accompanied by feeling sick, vomiting, suspect suffer from cholelithiasis, ultrasound diagnosis is done by Sui Lai hospital, and doctor is used for this After invention B ultrasonic couplant, skin is without anaphylaxis, and image quality is high.

6, Feng's ××, man, 52 years old, builder, people from Hefei ,Anhui.Patient causes chest, abdominal part to be subject to due to work accidentally Wound, during ultrasound diagnosis, doctor is used for B ultrasonic couplant of the present invention, and patient infects without anaphylaxis, wound, and imaging Definition is high.

Claims

1. a B ultrasonic couplant, it is characterised in that: make described couplant effective ingredient raw material composition and parts by weight be:

A kind of B ultrasonic couplant the most according to claim 1, it is characterised in that: make the former of described couplant effective ingredient Material forms and parts by weight are:

5. the preparation method of the B ultrasonic couplant as described in any one of Claims 1 to 4, it is characterised in that: include following work Skill step:

(1) ligustrum sinense, Anaer Cygnoides domestica Brisson, Herb Pararuelliae delavayanae, Galla Chinensis, Radix clerodendri fragrantis (Radix Clerodendri Philippini) and Herba Lysimachiae Grammicae are gone the removal of impurity, clean, put in container, Add 6 times amount distilled water, soak 2～3 hours, then add 5 times amount distilled water, decoct 2 hours, extract decoction liquor；Add 4 times Amount distilled water, decocts 1.5 hours, extracts decoction liquor, finally merges the decoction liquor extracted 2 times, filter, obtain filtrate, standby；

(2) Folium Pini, Radix seu Folium Alchorneae trewioidis and attached column have been spent the removal of impurity, cleaned and dry, smash to pieces in being placed in mortar, obtained 120 purposes thin Powder, standby；

(3) Herba leucadis zeylanicae, Herba Blumeae Lacerae, Aloe and Folium Allii fistulosi are gone the removal of impurity, clean, be placed in strand juice in container, filter, obtain filtered juice, standby With；

(4) Radix Sophorae Flavescentis, Rhizoma Coptidis and Rhizoma Chuanxiong are gone the removal of impurity, clean section, add fresh ginger juice and boiled water, mix thoroughly, treat that juice exhausts Frying to surface buff degree of being with slow fire afterwards, taking-up cools, and smashs to pieces in being placed in mortar, obtains the fine powder of 140 mesh, standby；

(5) by the filtrate of step (1) gained, step (2), the fine powder of step (4) gained, the filtered juice mixing of step (3) gained, and Adding Lac Bovis seu Bubali and glycerol, after stirring and dissolving is uniform, be slowly added dropwise the NaOH solution of 1mol/L, regulation pH value, to 7.0, stands 24 afterwards Hour, to extract and filter, concentration is that at 60 DEG C, relative density is the thick paste of 1.11～1.13, and canning sealing is described B ultrasonic coupling Mixture.