CN103239731B - Edible buccal patch for treating dental ulcer - Google Patents
Edible buccal patch for treating dental ulcer Download PDFInfo
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- CN103239731B CN103239731B CN201310149678.1A CN201310149678A CN103239731B CN 103239731 B CN103239731 B CN 103239731B CN 201310149678 A CN201310149678 A CN 201310149678A CN 103239731 B CN103239731 B CN 103239731B
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Abstract
The invention relates to a buccal patch, and in particular relates to an edible buccal patch for treating dental ulcer. The edible buccal patch is prepared by the steps of: partially dewatering a bio-cellulose membrane, soaking in a liquid medicine and then drying at low temperature. The edible buccal patch contains Western medicine liquid, traditional Chinese medicine liquid and vegetable juice. The product disclosed by the invention has good paste property, can play good adhesion effect even if various chemical binders are not added, can control slow release of the liquid medicine, and prolongs the action time of the product. The edible buccal patch can be directly eaten, or even has the health-care function. Therefore, the product does not damage a human body even if being used at night long or eaten by a consumer by an error. The edible buccal patch also adopts a combined treatment mode of traditional Chinese medicine and western medicine, and has good treatment effect.
Description
Technical field
The present invention relates to one and suck paster, particularly relate to a kind of paster of sucking of edible treatment oral ulcer.
Background technology
Oral ulcer (oral ulcer, OU), is called again " aphtha ", is a kind of common oral mucosa disease, is that the integrity generation persistence of oral mucosa epithelium is damaged or destroy, superficial necrosis the form depression that comes off.The cause of disease is comparatively complicated, may with mucosal epithelium layer immunoreaction abnormity and mucosa injury after protect Reconstruction of The Function imbalance to have close relationship.Quantity research shows greatly, and OU morbidity is relevant to following factors: heredity, immune disorder, wound, virus or antibacterial infection, autoimmune, gastroenteropathy, anemia, endocrine disturbance, malnutrition and psychentonia etc.The sickness rate of OU is very high, and the sickness rate of population can be up to more than 25%.Wherein common with recurrent oral ulceration, while sending out at that time, more, repeatedly to show effect, the course of disease is generally 7-10 days, has comparatively violent causalgia between stage of attack, has brought great impact to patient's work, studying and living, has a strong impact on patient's quality of life.
At present clinical treatment carries out antiinflammatory, pain relieving, anticorrosion and promote the treatment of healing mainly for ulcer wound surface, and common dosage form has gargarism, buccal tablet etc., but because action time is short, and cannot directly act on affected part and poor effect often.There is in recent years directly acting on the patch products in oral ulcer affected part, wherein often comprised the carrier and the adhesive ingredients that contain medicine.But in this series products, first often contain unedible carrier components, if in use eaten by mistake, can cause harmful effect to the health of consumer; Secondly the bonding effect of this series products is not good, when use, usually can come off, often need to use multiple adhesive composition in order to improve adhesiving effect, because adhesive composition often has certain toxicity, therefore increased on the one hand the potential safety hazard of product, also can make on the other hand the equal relative complex of its composition and engineering, improve production cost; Although this series products can make medicine directly act on affected part again, because sustained release performance is limited, therefore its drug effect cannot act on the longer time.
Biology cellulose (Biocellulose) refers to the cellulosic general name by the part bacterial strain metabolism growth in acetic acid Pseudomonas.It is widely used at field of food as outstanding dietary fiber source at present.In addition, because it has superfine space network structure, be therefore also progressively used to the fields such as medical dressing.Biology cellulose has very high water content, and still has very strong rehydration performance after its dehydration.There is no at present report and use it for the product of preparing mouth paster class.
Summary of the invention
For the problems referred to above, what the invention provides a kind of edible treatment oral ulcer sucks paster and preparation method thereof.
The paster of sucking that the invention provides a kind of edible treatment oral ulcer, it is soaked in medicinal liquid after partial dehydration by biology cellulose film, and then cold drying is made.
Wherein said partial dehydration is that biology cellulose film is dewatered to water content between 30-60%.
Edible treatment oral ulcer described in the present invention suck paster, wherein said biology cellulose film is standby through shallow tray fermentation legal system by acetobacter xylinum or gluconate pyracetobacillus, and through washing purification.
Edible treatment oral ulcer described in the present invention suck paster, in wherein said medicinal liquid, comprise Western medicine medicinal liquid, described Western medicine medicinal liquid is one or more the aqueous solution in hibitane, sulphuric acid Gentamicin, chlortetracycline, amoxicillin, nitrofural, levamisole and lysozyme.In this Western medicine medicinal liquid, the concentration of effective ingredient is 0.1-1ppm.
Edible treatment oral ulcer described in the present invention suck paster, in wherein said medicinal liquid, also comprise traditional Chinese medicine liquid, described traditional Chinese medicine liquid comprises: Herba Taraxaci 5-10 weight portion, Radix Glycyrrhizae 5-10 weight portion, Herba Houttuyniae 3-6 weight portion, Cortex Phellodendri 3-6 weight portion, Fructus Forsythiae 1-2 weight portion, Rhizoma Phragmitis 1-2 weight portion, Folium Mori 5-10 weight portion, Pericarpium Citri Reticulatae 1-2 weight portion, Fructus Jujubae 1-2 weight portion, Herba Hedyotidis Diffusae 3-6 weight portion, Rabdosia rubescens 1-2 weight portion, Endothelium Corneum Gigeriae Galli 1-2 weight portion, Galla Chinensis 1-2 weight portion and Folium Ligustri Lucidi 1-2 weight portion add the decocting liquid of 50-100 weight parts water.In described traditional Chinese medicine liquid, also can comprise the Borax of 1-2 weight portion and the Mel of 3-5 weight portion.
Edible treatment oral ulcer described in the present invention suck paster, in wherein said medicinal liquid, also comprise vegetable juice, described vegetable juice is Radix Dauci Sativae juice and Succus Momordicae charantiae.Wherein Radix Dauci Sativae juice can mix with any part by weight with Succus Momordicae charantiae, but preferred part by weight is 1:2.
Edible treatment oral ulcer described in the present invention suck paster, the part by weight of described medicinal liquid Chinese medicine and western medicine medicinal liquid and traditional Chinese medicine liquid and vegetable juice is (0.5-1): (8-10): (3-5).Preferred ratio is 1:10:3.
The present invention also provides a kind of preparation method of sucking paster of edible treatment oral ulcer, and its step comprises:
1) prepare biology cellulose film: preparation culture medium, after sterilizing, inoculate acetobacter xylinum or gluconate pyracetobacillus, at 25-30 DEG C, with tray static fermentation method fermentation 1-3 days, then purify with weak lye and deionized water cyclic washing;
2) above-mentioned biology cellulose membrane portions is dewatered to water content between 30-60%;
3) preparating liquid:
A, to get one or more in hibitane, gentamycin sulfate, chlortetracycline, amoxicillin, nitrofural, levamisole and lysozyme soluble in water, and making concentration is the Western medicine medicinal liquid of 0.1-1ppm;
B, get Herba Taraxaci 5-10 weight portion, Radix Glycyrrhizae 5-10 weight portion, Herba Houttuyniae 3-6 weight portion, Cortex Phellodendri 3-6 weight portion, Fructus Forsythiae 1-2 weight portion, Rhizoma Phragmitis 1-2 weight portion, Folium Mori 5-10 weight portion, Pericarpium Citri Reticulatae 1-2 weight portion, Fructus Jujubae 1-2 weight portion, Herba Hedyotidis Diffusae 3-6 weight portion, Rabdosia rubescens 1-2 weight portion, Endothelium Corneum Gigeriae Galli 1-2 weight portion, Galla Chinensis 1-2 weight portion and Folium Ligustri Lucidi 1-2 weight portion and add the decocting of 50-100 weight portion to boil, cold filtration is made traditional Chinese medicine liquid;
C, get Radix Dauci Sativae and Fructus Momordicae charantiae is squeezed the juice respectively, merge Radix Dauci Sativae juice and Succus Momordicae charantiae and make vegetable juice;
D, by above-mentioned Western medicine medicinal liquid, traditional Chinese medicine liquid and vegetable juice according to (0.5-1): (8-10): part by weight (3-5) is mixed and made into medicinal liquid;
4) will in step 1), make biology cellulose film in step 2) soak 5-12 hour in the medicinal liquid that makes;
5) cold drying, to water content lower than 20%, gets product.
The preparation method of sucking paster of above-mentioned edible treatment oral ulcer has also added the Borax of 1-2 weight portion and the Mel of 3-5 weight portion in described traditional Chinese medicine liquid in decocting liquid, stirs, and is prepared into traditional Chinese medicine liquid.
Above-mentioned steps 2) in preferably biology cellulose membrane portions is dewatered to water content between 40-50%.Preferably dewater by the mode of mechanical compress or cold drying.
Adopt method of the present invention can make a kind of paster of sucking that is used for the treatment of oral ulcer.It is using biology cellulose film as carrier, and entrance will imbibition, makes it have good stickup performance, need not add various chemical adhesives and also can play good adhesiving effect; In addition, because biology cellulose has meticulous space network structure, it can control the slow release of medicinal liquid, extends the action time of product; And still direct bio-carrier that eat and that have health care of biology cellulose, even if therefore this product uses whole night or is eaten by mistake all and can not damage human body by consumer.The present invention has also adopted the mode of therapy of combining Chinese and Western medicine, and in western medicine composition, hibitane, sulphuric acid Gentamicin, chlortetracycline, amoxicillin, nitrofural, levamisole and lysozyme can anti-inflammation and sterilizations, and pain relieving also promotes wound healing; And Chinese medicine ingredients Herba Taraxaci, Radix Glycyrrhizae, Herba Houttuyniae, Cortex Phellodendri, Fructus Forsythiae, Rhizoma Phragmitis, Folium Mori, Pericarpium Citri Reticulatae, Fructus Jujubae, Herba Hedyotidis Diffusae, Rabdosia rubescens, Endothelium Corneum Gigeriae Galli, Galla Chinensis, the Folium Ligustri Lucidi, Borax, Mel and Succus Momordicae charantiae and Radix Dauci Sativae juice can heat-clearing and toxic substances removing, antibacterial pain relieving, improve immunity etc., can play the effect of auxiliary treatment, there is good therapeutic effect.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: the preparation of sucking paster of edible treatment oral ulcer
Preparation culture medium, inoculates acetobacter xylinum after sterilizing, ferment 2 days, then purify with weak lye and deionized water cyclic washing at 28 DEG C by tray static fermentation method, makes biology cellulose film; By mechanical compression method by biology cellulose membrane portions dewater to water content be 50%, make the biology cellulose film of partial dehydration.。
Get hibitane, gentamycin sulfate and levamisole soluble in water, making concentration is the Western medicine medicinal liquid of 0.5ppm;
Get Herba Taraxaci 8 weight portions, Radix Glycyrrhizae 10 weight portions, Herba Houttuyniae 5 weight portions, Cortex Phellodendri 3 weight portions, Fructus Forsythiae 1 weight portion, Rhizoma Phragmitis 1 weight portion, Folium Mori 5 weight portions, Pericarpium Citri Reticulatae 2 weight portions, Fructus Jujubae 1 weight portion, Herba Hedyotidis Diffusae 3 weight portions, Rabdosia rubescens 1 weight portion, Endothelium Corneum Gigeriae Galli 1 weight portion, Galla Chinensis 1 weight portion and the Folium Ligustri Lucidi 1 weight portion and add the decocting of 80 weight portions to boil, cold filtration is made traditional Chinese medicine liquid;
Get Radix Dauci Sativae and Fructus Momordicae charantiae is squeezed the juice respectively, merge Radix Dauci Sativae juice and Succus Momordicae charantiae is made vegetable juice by the part by weight of 1:2;
Above-mentioned Western medicine medicinal liquid, traditional Chinese medicine liquid and vegetable juice are mixed and made into medicinal liquid according to the part by weight of 0.5:8:3;
The biology cellulose film of the partial dehydration making is soaked 8 hours in medicinal liquid, and after taking out, cold drying to water content is 15%, gets product.
Embodiment 2: the preparation of sucking paster of edible treatment oral ulcer
Preparation culture medium, inoculates gluconate pyracetobacillus after sterilizing, ferment 1 day, then purify with weak lye and deionized water cyclic washing at 30 DEG C by tray static fermentation method, makes biology cellulose film; By cold drying by biology cellulose membrane portions dewater to water content be 40%, make the biology cellulose film of partial dehydration.
Depletion mycin, amoxicillin, nitrofural, levamisole and lysozyme are soluble in water, and making concentration is the Western medicine medicinal liquid of 1ppm;
Getting Herba Taraxaci 10 weight portions, Radix Glycyrrhizae 5 weight portions, Herba Houttuyniae 6 weight portions, Cortex Phellodendri 5 weight portions, Fructus Forsythiae 2 weight portions, Rhizoma Phragmitis 1 weight portion, Folium Mori 6 weight portions, Pericarpium Citri Reticulatae 1 weight portion, Fructus Jujubae 1 weight portion, Herba Hedyotidis Diffusae 5 weight portions, Rabdosia rubescens 2 weight portions, Endothelium Corneum Gigeriae Galli 1 weight portion, Galla Chinensis 2 weight portions and the Folium Ligustri Lucidi 1 weight portion adds the decocting of 100 weight portions to boil, after cold filtration, add again the Borax of 1 weight portion and the Mel of 5 weight portions, after stirring, be prepared into traditional Chinese medicine liquid;
Get Radix Dauci Sativae and Fructus Momordicae charantiae is squeezed the juice respectively, merge Radix Dauci Sativae juice and Succus Momordicae charantiae is made vegetable juice by the part by weight of 1:2;
Above-mentioned Western medicine medicinal liquid, traditional Chinese medicine liquid and vegetable juice are mixed and made into medicinal liquid according to the part by weight of 1:8:5;
The biology cellulose film of the partial dehydration making was soaked after 12 hours in medicinal liquid, and after taking out, cold drying to water content is 10%, gets product.
Experimental example:
Select 18 routine oral ulcer patients as experimental subject, be divided at random 3 groups according to one group of 6 people.Wherein use the paster of sucking of edible treatment oral ulcer in the embodiment of the present invention 1 for the 1st group; Use the paster of sucking of edible treatment oral ulcer in embodiment 2 for the 2nd group; Directly use the biology cellulose film (water content 15%) of partial dehydration for the 3rd group.Observe ulcer healing situation every day, record the time that ulcer heals completely, average as healing time, the results are shown in following table:
| Group | The 1st group | The 2nd group | The 3rd group |
| Healing time (my god) | 4.1 | 3.7 | 8.8 |
Visible, use sucking paster and can making ulcer quickly-healing of edible treatment oral ulcer of the present invention, there is the technique effect for the treatment of oral ulcer.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (1)
- Edible treatment oral ulcer suck a paster, be characterised in that: it is soaked in medicinal liquid after partial dehydration by biology cellulose film, and then cold drying is made; Wherein said medicinal liquid comprises Western medicine medicinal liquid and traditional Chinese medicine liquid; Described Western medicine medicinal liquid is one or more the aqueous solution in hibitane, sulphuric acid Gentamicin, chlortetracycline, amoxicillin, nitrofural, levamisole and lysozyme, and in this Western medicine medicinal liquid, the concentration of effective ingredient is 0.1-1ppm; Described traditional Chinese medicine liquid comprises: Herba Taraxaci 5-10 weight portion, Radix Glycyrrhizae 5-10 weight portion, Herba Houttuyniae 3-6 weight portion, Cortex Phellodendri 3-6 weight portion, Fructus Forsythiae 1-2 weight portion, Rhizoma Phragmitis 1-2 weight portion, Folium Mori 5-10 weight portion, Pericarpium Citri Reticulatae 1-2 weight portion, Fructus Jujubae 1-2 weight portion, Herba Hedyotidis Diffusae 3-6 weight portion, Rabdosia rubescens 1-2 weight portion, Endothelium Corneum Gigeriae Galli 1-2 weight portion, Galla Chinensis 1-2 weight portion and Folium Ligustri Lucidi 1-2 weight portion add the decocting liquid of 50-100 weight parts water.Edible treatment oral ulcer according to claim 1 suck paster, be characterised in that: wherein said biology cellulose film is standby through shallow tray fermentation legal system by acetobacter xylinum or gluconate pyracetobacillus, and through washing purification, described partial dehydration is that biology cellulose film is dewatered to water content between 30-60%.Edible treatment oral ulcer according to claim 1 and 2 suck paster, be characterised in that: in described traditional Chinese medicine liquid, also comprise the Borax of 1-2 weight portion and the Mel of 3-5 weight portion.Edible treatment oral ulcer according to claim 1 and 2 suck paster, be characterised in that: in wherein said medicinal liquid, also comprise vegetable juice, described vegetable juice is that Radix Dauci Sativae juice and Succus Momordicae charantiae mix with 1:2 part by weight.Edible treatment oral ulcer according to claim 4 suck paster, be characterised in that: the part by weight of described medicinal liquid Chinese medicine and western medicine medicinal liquid and traditional Chinese medicine liquid and vegetable juice is (0.5-1): (8-10): (3-5).6. the preparation method of sucking paster of edible treatment oral ulcer in claim 5, is characterized in that: step comprises:1) prepare biology cellulose film: preparation culture medium, after sterilizing, inoculate acetobacter xylinum or gluconate pyracetobacillus, at 25-30 DEG C, with tray static fermentation method fermentation 1-3 days, then purify with weak lye and deionized water cyclic washing;2) above-mentioned biology cellulose membrane portions is dewatered to water content between 30-60%;3) preparating liquid:A, to get one or more in hibitane, gentamycin sulfate, chlortetracycline, amoxicillin, nitrofural, levamisole and lysozyme soluble in water, and making concentration is the Western medicine medicinal liquid of 0.1-1ppm;B, get Herba Taraxaci 5-10 weight portion, Radix Glycyrrhizae 5-10 weight portion, Herba Houttuyniae 3-6 weight portion, Cortex Phellodendri 3-6 weight portion, Fructus Forsythiae 1-2 weight portion, Rhizoma Phragmitis 1-2 weight portion, Folium Mori 5-10 weight portion, Pericarpium Citri Reticulatae 1-2 weight portion, Fructus Jujubae 1-2 weight portion, Herba Hedyotidis Diffusae 3-6 weight portion, Rabdosia rubescens 1-2 weight portion, Endothelium Corneum Gigeriae Galli 1-2 weight portion, Galla Chinensis 1-2 weight portion and Folium Ligustri Lucidi 1-2 weight portion and add the decocting of 50-100 weight portion to boil, cold filtration is made traditional Chinese medicine liquid;C, get Radix Dauci Sativae and Fructus Momordicae charantiae is squeezed the juice respectively, merge Radix Dauci Sativae juice and Succus Momordicae charantiae and make vegetable juice;D, by above-mentioned Western medicine medicinal liquid, traditional Chinese medicine liquid and vegetable juice according to (0.5-1): (8-10): part by weight (3-5) is mixed and made into medicinal liquid;3) will in step 1), make biology cellulose film in step 2) soak 5-12 hour in the medicinal liquid that makes;4) cold drying, to water content lower than 20%, gets product.7. the preparation method of sucking paster of edible treatment oral ulcer according to claim 6, is characterized in that: above-mentioned steps 2) described in be to dewater by the mode of mechanical compress or cold drying by biology cellulose membrane portions dehydration.8. the preparation method of sucking paster of edible treatment oral ulcer according to claim 6, it is characterized in that: in described traditional Chinese medicine liquid, also in decocting liquid, added the Borax of 1-2 weight portion and the Mel of 3-5 weight portion, stir, be prepared into traditional Chinese medicine liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310149678.1A CN103239731B (en) | 2013-04-26 | 2013-04-26 | Edible buccal patch for treating dental ulcer |
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| CN201310149678.1A CN103239731B (en) | 2013-04-26 | 2013-04-26 | Edible buccal patch for treating dental ulcer |
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| CN103239731B true CN103239731B (en) | 2014-11-19 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103589167A (en) * | 2013-11-13 | 2014-02-19 | 哈尔滨派特纳生物科技开发有限公司 | Edible bitter gourd film |
| CN104587034B (en) * | 2015-03-03 | 2017-05-17 | 张远强 | New application of a medicinal composition in treating oral ulcer |
| CN112426242B (en) * | 2020-12-09 | 2022-08-16 | 海南光宇生物科技有限公司 | Biological cellulose tooth cleaning tooth socket |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101095800A (en) * | 2006-06-29 | 2008-01-02 | 朱靖华 | Development of paster for treating mouth ulcer |
| CN101138586A (en) * | 2006-09-08 | 2008-03-12 | 王治效 | Riboflavin natural indigo mouth ulcer paster |
| CN101444567A (en) * | 2007-11-26 | 2009-06-03 | 天津市金圭谷木糖醇有限公司 | Double-layer traditional Chinese medicine patch for treating oral ulcer and preparation method thereof |
| CN101745141A (en) * | 2010-01-15 | 2010-06-23 | 东华大学 | Bacterial cellulose (BC) based antibacterial dry film applied to acute injury as well as preparation method and application thereof |
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